-- dump date 20140619_144917 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243233000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 243233000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 243233000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243233000004 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 243233000005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233000006 S-adenosylmethionine binding site [chemical binding]; other site 243233000007 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243233000008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243233000009 P-loop; other site 243233000010 Magnesium ion binding site [ion binding]; other site 243233000011 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243233000012 Magnesium ion binding site [ion binding]; other site 243233000013 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243233000014 ParB-like nuclease domain; Region: ParBc; pfam02195 243233000015 ATP synthase I chain; Region: ATP_synt_I; cl09170 243233000016 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 243233000017 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243233000018 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 243233000019 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243233000020 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 243233000021 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 243233000022 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 243233000023 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243233000024 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243233000025 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243233000026 beta subunit interaction interface [polypeptide binding]; other site 243233000027 Walker A motif; other site 243233000028 ATP binding site [chemical binding]; other site 243233000029 Walker B motif; other site 243233000030 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243233000031 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243233000032 core domain interface [polypeptide binding]; other site 243233000033 delta subunit interface [polypeptide binding]; other site 243233000034 epsilon subunit interface [polypeptide binding]; other site 243233000035 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243233000036 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243233000037 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243233000038 alpha subunit interaction interface [polypeptide binding]; other site 243233000039 Walker A motif; other site 243233000040 ATP binding site [chemical binding]; other site 243233000041 Walker B motif; other site 243233000042 inhibitor binding site; inhibition site 243233000043 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243233000044 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243233000045 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243233000046 gamma subunit interface [polypeptide binding]; other site 243233000047 epsilon subunit interface [polypeptide binding]; other site 243233000048 LBP interface [polypeptide binding]; other site 243233000049 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 243233000050 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243233000051 Substrate binding site; other site 243233000052 Mg++ binding site; other site 243233000053 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 243233000054 active site 243233000055 substrate binding site [chemical binding]; other site 243233000056 CoA binding site [chemical binding]; other site 243233000057 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243233000058 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243233000059 glutaminase active site [active] 243233000060 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243233000061 dimer interface [polypeptide binding]; other site 243233000062 active site 243233000063 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243233000064 dimer interface [polypeptide binding]; other site 243233000065 active site 243233000066 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 243233000067 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243233000068 active site 243233000069 HIGH motif; other site 243233000070 KMSKS motif; other site 243233000071 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243233000072 tRNA binding surface [nucleotide binding]; other site 243233000073 anticodon binding site; other site 243233000074 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 243233000075 dimer interface [polypeptide binding]; other site 243233000076 putative tRNA-binding site [nucleotide binding]; other site 243233000077 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 243233000078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243233000079 inhibitor-cofactor binding pocket; inhibition site 243233000080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000081 catalytic residue [active] 243233000082 RNA methyltransferase, RsmE family; Region: TIGR00046 243233000083 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 243233000084 Predicted integral membrane protein [Function unknown]; Region: COG5615 243233000085 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 243233000086 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 243233000087 putative metal binding site [ion binding]; other site 243233000088 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243233000089 HSP70 interaction site [polypeptide binding]; other site 243233000090 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 243233000091 ATP binding site [chemical binding]; other site 243233000092 active site 243233000093 substrate binding site [chemical binding]; other site 243233000094 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 243233000095 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243233000096 active site 243233000097 NTP binding site [chemical binding]; other site 243233000098 metal binding triad [ion binding]; metal-binding site 243233000099 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243233000100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243233000101 Zn2+ binding site [ion binding]; other site 243233000102 Mg2+ binding site [ion binding]; other site 243233000103 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243233000104 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 243233000105 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243233000106 putative active site [active] 243233000107 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243233000108 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243233000109 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243233000110 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 243233000111 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243233000112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233000113 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243233000114 MULE transposase domain; Region: MULE; pfam10551 243233000115 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 243233000116 active site 243233000117 NTP binding site [chemical binding]; other site 243233000118 metal binding triad [ion binding]; metal-binding site 243233000119 antibiotic binding site [chemical binding]; other site 243233000120 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 243233000121 putative active site [active] 243233000122 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243233000123 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 243233000124 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 243233000125 BRO family, N-terminal domain; Region: Bro-N; pfam02498 243233000126 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 243233000127 phosphogluconate dehydratase; Validated; Region: PRK09054 243233000128 6-phosphogluconate dehydratase; Region: edd; TIGR01196 243233000129 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 243233000130 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 243233000131 active site 243233000132 intersubunit interface [polypeptide binding]; other site 243233000133 catalytic residue [active] 243233000134 DAK2 domain; Region: Dak2; cl03685 243233000135 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 243233000136 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 243233000137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243233000138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243233000139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 243233000140 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 243233000141 catalytic triad [active] 243233000142 dimer interface [polypeptide binding]; other site 243233000143 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 243233000144 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 243233000145 Active_site [active] 243233000146 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 243233000147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 243233000148 homodimer interface [polypeptide binding]; other site 243233000149 metal binding site [ion binding]; metal-binding site 243233000150 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 243233000151 homodimer interface [polypeptide binding]; other site 243233000152 active site 243233000153 putative chemical substrate binding site [chemical binding]; other site 243233000154 metal binding site [ion binding]; metal-binding site 243233000155 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 243233000156 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243233000157 substrate binding site [chemical binding]; other site 243233000158 ATP binding site [chemical binding]; other site 243233000159 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 243233000160 Cellulose binding domain; Region: CBM_2; pfam00553 243233000161 Transposase domain (DUF772); Region: DUF772; pfam05598 243233000162 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233000163 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233000164 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243233000165 lipoyl attachment site [posttranslational modification]; other site 243233000166 Domain of unknown function DUF59; Region: DUF59; pfam01883 243233000167 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 243233000168 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243233000169 Walker A motif; other site 243233000170 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243233000171 trimer interface [polypeptide binding]; other site 243233000172 active site 243233000173 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243233000174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243233000175 inhibitor-cofactor binding pocket; inhibition site 243233000176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000177 catalytic residue [active] 243233000178 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243233000179 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243233000180 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243233000181 active site 243233000182 LssY C-terminus; Region: LssY_C; pfam14067 243233000183 transcription termination factor Rho; Provisional; Region: rho; PRK09376 243233000184 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 243233000185 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 243233000186 RNA binding site [nucleotide binding]; other site 243233000187 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243233000188 multimer interface [polypeptide binding]; other site 243233000189 Walker A motif; other site 243233000190 ATP binding site [chemical binding]; other site 243233000191 Walker B motif; other site 243233000192 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243233000193 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233000194 catalytic residues [active] 243233000195 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243233000196 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243233000197 putative acyl-acceptor binding pocket; other site 243233000198 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 243233000199 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 243233000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233000201 Walker A motif; other site 243233000202 ATP binding site [chemical binding]; other site 243233000203 Walker B motif; other site 243233000204 arginine finger; other site 243233000205 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243233000206 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 243233000207 UbiA prenyltransferase family; Region: UbiA; pfam01040 243233000208 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243233000209 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243233000210 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243233000211 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243233000212 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243233000213 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 243233000214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233000215 S-adenosylmethionine binding site [chemical binding]; other site 243233000216 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 243233000217 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243233000218 active site 243233000219 (T/H)XGH motif; other site 243233000220 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 243233000221 homodimer interface [polypeptide binding]; other site 243233000222 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 243233000223 active site pocket [active] 243233000224 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243233000225 putative active site [active] 243233000226 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243233000227 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 243233000228 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243233000229 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 243233000230 AMMECR1; Region: AMMECR1; pfam01871 243233000231 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 243233000232 putative ligand binding pocket/active site [active] 243233000233 putative metal binding site [ion binding]; other site 243233000234 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 243233000235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233000236 FeS/SAM binding site; other site 243233000237 glutathionine S-transferase; Provisional; Region: PRK10542 243233000238 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 243233000239 C-terminal domain interface [polypeptide binding]; other site 243233000240 GSH binding site (G-site) [chemical binding]; other site 243233000241 dimer interface [polypeptide binding]; other site 243233000242 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 243233000243 dimer interface [polypeptide binding]; other site 243233000244 N-terminal domain interface [polypeptide binding]; other site 243233000245 substrate binding pocket (H-site) [chemical binding]; other site 243233000246 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 243233000247 active site flap/lid [active] 243233000248 nucleophilic elbow; other site 243233000249 catalytic triad [active] 243233000250 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 243233000251 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 243233000252 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233000253 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243233000254 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243233000255 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 243233000256 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243233000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233000258 S-adenosylmethionine binding site [chemical binding]; other site 243233000259 hypothetical protein; Provisional; Region: PRK06771 243233000260 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 243233000261 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243233000262 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 243233000263 PilX N-terminal; Region: PilX_N; pfam14341 243233000264 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 243233000265 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 243233000266 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 243233000267 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243233000268 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 243233000269 Type II transport protein GspH; Region: GspH; pfam12019 243233000270 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 243233000271 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 243233000272 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243233000273 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243233000274 Walker A/P-loop; other site 243233000275 ATP binding site [chemical binding]; other site 243233000276 Q-loop/lid; other site 243233000277 ABC transporter signature motif; other site 243233000278 Walker B; other site 243233000279 D-loop; other site 243233000280 H-loop/switch region; other site 243233000281 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 243233000282 MPN+ (JAMM) motif; other site 243233000283 Zinc-binding site [ion binding]; other site 243233000284 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243233000285 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 243233000286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233000287 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243233000288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233000289 motif II; other site 243233000290 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243233000291 Transposase domain (DUF772); Region: DUF772; pfam05598 243233000292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233000293 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233000294 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243233000295 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243233000296 GatB domain; Region: GatB_Yqey; smart00845 243233000297 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243233000298 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243233000299 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243233000300 rod shape-determining protein MreB; Provisional; Region: PRK13927 243233000301 MreB and similar proteins; Region: MreB_like; cd10225 243233000302 nucleotide binding site [chemical binding]; other site 243233000303 Mg binding site [ion binding]; other site 243233000304 putative protofilament interaction site [polypeptide binding]; other site 243233000305 RodZ interaction site [polypeptide binding]; other site 243233000306 rod shape-determining protein MreC; Provisional; Region: PRK13922 243233000307 rod shape-determining protein MreC; Region: MreC; pfam04085 243233000308 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 243233000309 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 243233000310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243233000311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243233000312 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 243233000313 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243233000314 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243233000315 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 243233000316 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243233000317 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 243233000318 homodimer interface [polypeptide binding]; other site 243233000319 substrate-cofactor binding pocket; other site 243233000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000321 catalytic residue [active] 243233000322 Protein of unknown function (DUF493); Region: DUF493; pfam04359 243233000323 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 243233000324 MgtE intracellular N domain; Region: MgtE_N; smart00924 243233000325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 243233000326 Divalent cation transporter; Region: MgtE; pfam01769 243233000327 lipoate-protein ligase B; Provisional; Region: PRK14342 243233000328 lipoyl synthase; Provisional; Region: PRK05481 243233000329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233000330 FeS/SAM binding site; other site 243233000331 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 243233000332 dimer interface [polypeptide binding]; other site 243233000333 substrate binding site [chemical binding]; other site 243233000334 metal binding sites [ion binding]; metal-binding site 243233000335 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 243233000336 nickel binding site [ion binding]; other site 243233000337 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 243233000338 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 243233000339 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 243233000340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233000341 FeS/SAM binding site; other site 243233000342 HemN C-terminal domain; Region: HemN_C; pfam06969 243233000343 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 243233000344 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 243233000345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233000346 active site 243233000347 putative acetyltransferase; Provisional; Region: PRK03624 243233000348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243233000349 Coenzyme A binding pocket [chemical binding]; other site 243233000350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 243233000351 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 243233000352 Protein of unknown function (DUF524); Region: DUF524; pfam04411 243233000353 Predicted transcriptional regulator [Transcription]; Region: COG2378 243233000354 WYL domain; Region: WYL; pfam13280 243233000355 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 243233000356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233000357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233000358 ABC transporter; Region: ABC_tran_2; pfam12848 243233000359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233000360 hypothetical protein; Provisional; Region: PRK09256 243233000361 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 243233000362 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 243233000363 ApbE family; Region: ApbE; pfam02424 243233000364 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 243233000365 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 243233000366 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 243233000367 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 243233000368 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243233000369 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243233000370 P loop; other site 243233000371 GTP binding site [chemical binding]; other site 243233000372 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 243233000373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233000374 Walker A/P-loop; other site 243233000375 ATP binding site [chemical binding]; other site 243233000376 Q-loop/lid; other site 243233000377 ABC transporter signature motif; other site 243233000378 Walker B; other site 243233000379 D-loop; other site 243233000380 H-loop/switch region; other site 243233000381 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 243233000382 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 243233000383 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 243233000384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243233000385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243233000386 DNA binding residues [nucleotide binding] 243233000387 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243233000388 FAD binding site [chemical binding]; other site 243233000389 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 243233000390 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243233000391 homotetramer interface [polypeptide binding]; other site 243233000392 ligand binding site [chemical binding]; other site 243233000393 catalytic site [active] 243233000394 NAD binding site [chemical binding]; other site 243233000395 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243233000396 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243233000397 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243233000398 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243233000399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233000400 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 243233000401 active site 243233000402 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 243233000403 substrate binding site [chemical binding]; other site 243233000404 calcium/proton exchanger (cax); Region: cax; TIGR00378 243233000405 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243233000406 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 243233000407 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 243233000408 exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014 243233000409 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 243233000410 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 243233000411 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243233000412 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243233000413 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 243233000414 SLBB domain; Region: SLBB; pfam10531 243233000415 chain length determinant protein EpsF; Region: EpsF; TIGR03017 243233000416 Chain length determinant protein; Region: Wzz; cl15801 243233000417 Chain length determinant protein; Region: Wzz; cl15801 243233000418 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 243233000419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243233000420 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 243233000421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233000422 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243233000423 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243233000424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233000425 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233000426 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 243233000427 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 243233000428 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243233000429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233000430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233000431 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 243233000432 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 243233000433 active site 243233000434 metal binding site [ion binding]; metal-binding site 243233000435 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 243233000436 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 243233000437 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 243233000438 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 243233000439 putative substrate-binding site; other site 243233000440 nickel binding site [ion binding]; other site 243233000441 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 243233000442 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 243233000443 hydrogenase 1 large subunit; Provisional; Region: PRK10170 243233000444 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 243233000445 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 243233000446 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 243233000447 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243233000448 Protein of unknown function (DUF502); Region: DUF502; cl01107 243233000449 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 243233000450 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 243233000451 Walker A/P-loop; other site 243233000452 ATP binding site [chemical binding]; other site 243233000453 Q-loop/lid; other site 243233000454 ABC transporter signature motif; other site 243233000455 Walker B; other site 243233000456 D-loop; other site 243233000457 H-loop/switch region; other site 243233000458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 243233000459 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 243233000460 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243233000461 Di-iron ligands [ion binding]; other site 243233000462 Transposase; Region: DDE_Tnp_ISL3; pfam01610 243233000463 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243233000464 mce related protein; Region: MCE; pfam02470 243233000465 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243233000466 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243233000467 Walker A/P-loop; other site 243233000468 ATP binding site [chemical binding]; other site 243233000469 Q-loop/lid; other site 243233000470 ABC transporter signature motif; other site 243233000471 Walker B; other site 243233000472 D-loop; other site 243233000473 H-loop/switch region; other site 243233000474 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243233000475 Permease; Region: Permease; pfam02405 243233000476 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243233000477 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233000478 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233000479 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233000480 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233000481 Protein of unknown function (DUF466); Region: DUF466; pfam04328 243233000482 FAD binding domain; Region: FAD_binding_4; pfam01565 243233000483 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243233000484 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243233000485 dimer interface [polypeptide binding]; other site 243233000486 active site 243233000487 hypothetical protein; Reviewed; Region: PRK12497 243233000488 LppC putative lipoprotein; Region: LppC; pfam04348 243233000489 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 243233000490 putative ligand binding site [chemical binding]; other site 243233000491 Predicted methyltransferases [General function prediction only]; Region: COG0313 243233000492 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243233000493 putative SAM binding site [chemical binding]; other site 243233000494 putative homodimer interface [polypeptide binding]; other site 243233000495 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 243233000496 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243233000497 putative active site [active] 243233000498 putative metal binding site [ion binding]; other site 243233000499 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 243233000500 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 243233000501 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 243233000502 Putative integral membrane protein DUF46; Region: DUF46; cl17511 243233000503 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 243233000504 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243233000505 putative active site [active] 243233000506 putative metal binding site [ion binding]; other site 243233000507 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional; Region: PRK12779 243233000508 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 243233000509 homodimer interface [polypeptide binding]; other site 243233000510 chemical substrate binding site [chemical binding]; other site 243233000511 oligomer interface [polypeptide binding]; other site 243233000512 metal binding site [ion binding]; metal-binding site 243233000513 putative lysogenization regulator; Reviewed; Region: PRK00218 243233000514 Rdx family; Region: Rdx; cl01407 243233000515 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 243233000516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233000517 FeS/SAM binding site; other site 243233000518 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 243233000519 methylamine methyltransferase corrinoid protein reductive activase; Region: Rama_corrin_act; TIGR04270 243233000520 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 243233000521 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 243233000522 NifZ domain; Region: NifZ; pfam04319 243233000523 NifZ domain; Region: NifZ; pfam04319 243233000524 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 243233000525 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243233000526 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243233000527 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233000528 catalytic residue [active] 243233000529 NifT/FixU protein; Region: NifT; pfam06988 243233000530 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243233000531 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 243233000532 inhibitor-cofactor binding pocket; inhibition site 243233000533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000534 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233000535 catalytic loop [active] 243233000536 iron binding site [ion binding]; other site 243233000537 SIR2-like domain; Region: SIR2_2; pfam13289 243233000538 Flagellin N-methylase; Region: FliB; cl00497 243233000539 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 243233000540 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243233000541 NADPH bind site [chemical binding]; other site 243233000542 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243233000543 putative FMN binding site [chemical binding]; other site 243233000544 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 243233000545 ArsC family; Region: ArsC; pfam03960 243233000546 putative catalytic residues [active] 243233000547 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 243233000548 [2Fe-2S] cluster binding site [ion binding]; other site 243233000549 Transposase domain (DUF772); Region: DUF772; pfam05598 243233000550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233000551 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233000552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233000553 active site 243233000554 phosphorylation site [posttranslational modification] 243233000555 intermolecular recognition site; other site 243233000556 dimerization interface [polypeptide binding]; other site 243233000557 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 243233000558 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 243233000559 Nucleotide-binding sites [chemical binding]; other site 243233000560 Walker A motif; other site 243233000561 Switch I region of nucleotide binding site; other site 243233000562 Fe4S4 binding sites [ion binding]; other site 243233000563 Switch II region of nucleotide binding site; other site 243233000564 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 243233000565 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 243233000566 MoFe protein alpha/beta subunit interactions; other site 243233000567 Alpha subunit P cluster binding residues; other site 243233000568 FeMoco binding residues [chemical binding]; other site 243233000569 MoFe protein alpha subunit/Fe protein contacts; other site 243233000570 MoFe protein dimer/ dimer interactions; other site 243233000571 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 243233000572 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 243233000573 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 243233000574 MoFe protein beta/alpha subunit interactions; other site 243233000575 Beta subunit P cluster binding residues; other site 243233000576 MoFe protein beta subunit/Fe protein contacts; other site 243233000577 MoFe protein dimer/ dimer interactions; other site 243233000578 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243233000579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233000580 catalytic loop [active] 243233000581 iron binding site [ion binding]; other site 243233000582 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 243233000583 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 243233000584 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243233000585 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 243233000586 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 243233000587 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 243233000588 probable nitrogen fixation protein; Region: TIGR02935 243233000589 Rop-like; Region: Rop-like; cl02247 243233000590 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 243233000591 NifQ; Region: NifQ; pfam04891 243233000592 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 243233000593 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 243233000594 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243233000595 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 243233000596 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 243233000597 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243233000598 oligomer interface [polypeptide binding]; other site 243233000599 active site residues [active] 243233000600 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243233000601 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243233000602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233000603 Walker A motif; other site 243233000604 ATP binding site [chemical binding]; other site 243233000605 Walker B motif; other site 243233000606 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243233000607 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 243233000608 MT-A70; Region: MT-A70; cl01947 243233000609 cysteine desulfurase; Provisional; Region: PRK14012 243233000610 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243233000611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233000612 catalytic residue [active] 243233000613 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243233000614 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243233000615 trimerization site [polypeptide binding]; other site 243233000616 active site 243233000617 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 243233000618 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 243233000619 co-chaperone HscB; Provisional; Region: hscB; PRK03578 243233000620 DnaJ domain; Region: DnaJ; pfam00226 243233000621 HSP70 interaction site [polypeptide binding]; other site 243233000622 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 243233000623 chaperone protein HscA; Provisional; Region: hscA; PRK05183 243233000624 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 243233000625 nucleotide binding site [chemical binding]; other site 243233000626 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243233000627 SBD interface [polypeptide binding]; other site 243233000628 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243233000629 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233000630 catalytic loop [active] 243233000631 iron binding site [ion binding]; other site 243233000632 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 243233000633 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 243233000634 active site 243233000635 catalytic residues [active] 243233000636 metal binding site [ion binding]; metal-binding site 243233000637 Nitrogen fixation protein NifW; Region: NifW; pfam03206 243233000638 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243233000639 dimer interface [polypeptide binding]; other site 243233000640 [2Fe-2S] cluster binding site [ion binding]; other site 243233000641 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243233000642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233000643 catalytic loop [active] 243233000644 iron binding site [ion binding]; other site 243233000645 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 243233000646 putative GSH binding site [chemical binding]; other site 243233000647 catalytic residues [active] 243233000648 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 243233000649 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 243233000650 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243233000651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233000652 Walker A motif; other site 243233000653 ATP binding site [chemical binding]; other site 243233000654 Walker B motif; other site 243233000655 arginine finger; other site 243233000656 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243233000657 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 243233000658 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243233000659 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243233000660 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243233000661 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 243233000662 active site 243233000663 NTP binding site [chemical binding]; other site 243233000664 metal binding triad [ion binding]; metal-binding site 243233000665 antibiotic binding site [chemical binding]; other site 243233000666 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 243233000667 Protein of unknown function (DUF511); Region: DUF511; cl01114 243233000668 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 243233000669 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243233000670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233000671 ATP binding site [chemical binding]; other site 243233000672 putative Mg++ binding site [ion binding]; other site 243233000673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243233000674 non-specific DNA binding site [nucleotide binding]; other site 243233000675 salt bridge; other site 243233000676 sequence-specific DNA binding site [nucleotide binding]; other site 243233000677 Domain of unknown function (DUF955); Region: DUF955; pfam06114 243233000678 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 243233000679 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243233000680 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243233000681 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243233000682 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243233000683 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243233000684 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243233000685 Helix-turn-helix domain; Region: HTH_17; pfam12728 243233000686 putative transposase OrfB; Reviewed; Region: PHA02517 243233000687 HTH-like domain; Region: HTH_21; pfam13276 243233000688 Integrase core domain; Region: rve; pfam00665 243233000689 Integrase core domain; Region: rve_3; pfam13683 243233000690 Transposase; Region: HTH_Tnp_1; cl17663 243233000691 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243233000692 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243233000693 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233000694 HEAT repeats; Region: HEAT_2; pfam13646 243233000695 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 243233000696 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 243233000697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233000698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233000699 catalytic residue [active] 243233000700 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243233000701 nucleoside/Zn binding site; other site 243233000702 dimer interface [polypeptide binding]; other site 243233000703 catalytic motif [active] 243233000704 GMP synthase; Reviewed; Region: guaA; PRK00074 243233000705 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243233000706 AMP/PPi binding site [chemical binding]; other site 243233000707 candidate oxyanion hole; other site 243233000708 catalytic triad [active] 243233000709 potential glutamine specificity residues [chemical binding]; other site 243233000710 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243233000711 ATP Binding subdomain [chemical binding]; other site 243233000712 Ligand Binding sites [chemical binding]; other site 243233000713 Dimerization subdomain; other site 243233000714 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243233000715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 243233000716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243233000717 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243233000718 active site 243233000719 hypothetical protein; Provisional; Region: PRK01254 243233000720 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 243233000721 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 243233000722 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 243233000723 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 243233000724 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 243233000725 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 243233000726 active site 243233000727 catalytic site [active] 243233000728 Predicted secreted protein [Function unknown]; Region: COG5501 243233000729 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 243233000730 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 243233000731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243233000732 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 243233000733 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 243233000734 Trp docking motif [polypeptide binding]; other site 243233000735 dimer interface [polypeptide binding]; other site 243233000736 active site 243233000737 small subunit binding site [polypeptide binding]; other site 243233000738 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 243233000739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 243233000740 substrate binding pocket [chemical binding]; other site 243233000741 membrane-bound complex binding site; other site 243233000742 hinge residues; other site 243233000743 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243233000744 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243233000745 dimer interface [polypeptide binding]; other site 243233000746 putative anticodon binding site; other site 243233000747 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243233000748 motif 1; other site 243233000749 active site 243233000750 motif 2; other site 243233000751 motif 3; other site 243233000752 peptide chain release factor 2; Validated; Region: prfB; PRK00578 243233000753 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243233000754 RF-1 domain; Region: RF-1; pfam00472 243233000755 Spore Coat Protein U domain; Region: SCPU; pfam05229 243233000756 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 243233000757 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 243233000758 PapC C-terminal domain; Region: PapC_C; pfam13953 243233000759 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 243233000760 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 243233000761 Spore Coat Protein U domain; Region: SCPU; pfam05229 243233000762 Transposase domain (DUF772); Region: DUF772; pfam05598 243233000763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233000764 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233000765 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 243233000766 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 243233000767 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 243233000768 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 243233000769 catalytic motif [active] 243233000770 Catalytic residue [active] 243233000771 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 243233000772 Protein of unknown function (DUF541); Region: SIMPL; cl01077 243233000773 Uncharacterized conserved protein [Function unknown]; Region: COG2968 243233000774 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 243233000775 HflK protein; Region: hflK; TIGR01933 243233000776 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 243233000777 HflC protein; Region: hflC; TIGR01932 243233000778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243233000779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243233000780 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 243233000781 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243233000782 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 243233000783 Cu(I) binding site [ion binding]; other site 243233000784 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243233000785 muropeptide transporter; Reviewed; Region: ampG; PRK11902 243233000786 muropeptide transporter; Validated; Region: ampG; cl17669 243233000787 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 243233000788 putative active site [active] 243233000789 putative catalytic site [active] 243233000790 putative DNA binding site [nucleotide binding]; other site 243233000791 putative phosphate binding site [ion binding]; other site 243233000792 metal binding site A [ion binding]; metal-binding site 243233000793 putative AP binding site [nucleotide binding]; other site 243233000794 putative metal binding site B [ion binding]; other site 243233000795 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 243233000796 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 243233000797 Transglycosylase; Region: Transgly; pfam00912 243233000798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243233000799 Competence protein A; Region: Competence_A; pfam11104 243233000800 Cell division protein FtsA; Region: FtsA; cl17206 243233000801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243233000802 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 243233000803 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 243233000804 Pilus assembly protein, PilO; Region: PilO; pfam04350 243233000805 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 243233000806 Pilus assembly protein, PilP; Region: PilP; pfam04351 243233000807 AMIN domain; Region: AMIN; pfam11741 243233000808 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243233000809 Secretin and TonB N terminus short domain; Region: STN; smart00965 243233000810 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243233000811 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243233000812 shikimate kinase; Reviewed; Region: aroK; PRK00131 243233000813 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243233000814 ADP binding site [chemical binding]; other site 243233000815 magnesium binding site [ion binding]; other site 243233000816 putative shikimate binding site; other site 243233000817 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243233000818 active site 243233000819 dimer interface [polypeptide binding]; other site 243233000820 metal binding site [ion binding]; metal-binding site 243233000821 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 243233000822 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243233000823 substrate binding site [chemical binding]; other site 243233000824 active site 243233000825 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243233000826 ADP-ribose binding site [chemical binding]; other site 243233000827 dimer interface [polypeptide binding]; other site 243233000828 active site 243233000829 nudix motif; other site 243233000830 metal binding site [ion binding]; metal-binding site 243233000831 Uncharacterized conserved protein [Function unknown]; Region: COG3189 243233000832 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 243233000833 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 243233000834 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 243233000835 FAD binding pocket [chemical binding]; other site 243233000836 FAD binding motif [chemical binding]; other site 243233000837 phosphate binding motif [ion binding]; other site 243233000838 beta-alpha-beta structure motif; other site 243233000839 NAD binding pocket [chemical binding]; other site 243233000840 Iron coordination center [ion binding]; other site 243233000841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233000842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233000843 metal binding site [ion binding]; metal-binding site 243233000844 active site 243233000845 I-site; other site 243233000846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233000847 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 243233000848 RmuC family; Region: RmuC; pfam02646 243233000849 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 243233000850 Protein of unknown function, DUF393; Region: DUF393; pfam04134 243233000851 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 243233000852 Walker A/P-loop; other site 243233000853 ATP binding site [chemical binding]; other site 243233000854 Q-loop/lid; other site 243233000855 ABC transporter signature motif; other site 243233000856 Walker B; other site 243233000857 D-loop; other site 243233000858 H-loop/switch region; other site 243233000859 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 243233000860 amino acid transporter; Region: 2A0306; TIGR00909 243233000861 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 243233000862 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243233000863 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 243233000864 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 243233000865 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243233000866 tetramer interface [polypeptide binding]; other site 243233000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000868 catalytic residue [active] 243233000869 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 243233000870 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 243233000871 tetramer interface [polypeptide binding]; other site 243233000872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000873 catalytic residue [active] 243233000874 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243233000875 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243233000876 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 243233000877 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243233000878 Uncharacterized conserved protein [Function unknown]; Region: COG2947 243233000879 threonine dehydratase; Reviewed; Region: PRK09224 243233000880 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243233000881 tetramer interface [polypeptide binding]; other site 243233000882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000883 catalytic residue [active] 243233000884 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 243233000885 putative Ile/Val binding site [chemical binding]; other site 243233000886 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 243233000887 putative Ile/Val binding site [chemical binding]; other site 243233000888 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 243233000889 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243233000890 active site 243233000891 dimer interface [polypeptide binding]; other site 243233000892 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243233000893 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 243233000894 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 243233000895 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243233000896 active site 243233000897 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243233000898 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 243233000899 nudix motif; other site 243233000900 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243233000901 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243233000902 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 243233000903 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243233000904 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 243233000905 mce related protein; Region: MCE; pfam02470 243233000906 mce related protein; Region: MCE; pfam02470 243233000907 mce related protein; Region: MCE; pfam02470 243233000908 Protein of unknown function (DUF330); Region: DUF330; pfam03886 243233000909 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 243233000910 VPS10 domain; Region: VPS10; smart00602 243233000911 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 243233000912 putative active site [active] 243233000913 Zn binding site [ion binding]; other site 243233000914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243233000915 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 243233000916 Helix-turn-helix domain; Region: HTH_18; pfam12833 243233000917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233000918 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243233000919 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243233000920 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243233000921 dimerization interface [polypeptide binding]; other site 243233000922 putative ATP binding site [chemical binding]; other site 243233000923 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233000924 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243233000925 Ligand binding site; other site 243233000926 Putative Catalytic site; other site 243233000927 DXD motif; other site 243233000928 quinolinate synthetase; Provisional; Region: PRK09375 243233000929 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 243233000930 Maf-like protein; Region: Maf; pfam02545 243233000931 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243233000932 active site 243233000933 dimer interface [polypeptide binding]; other site 243233000934 ribonuclease G; Provisional; Region: PRK11712 243233000935 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243233000936 homodimer interface [polypeptide binding]; other site 243233000937 oligonucleotide binding site [chemical binding]; other site 243233000938 TIGR02099 family protein; Region: TIGR02099 243233000939 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243233000940 nitrilase; Region: PLN02798 243233000941 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 243233000942 putative active site [active] 243233000943 catalytic triad [active] 243233000944 dimer interface [polypeptide binding]; other site 243233000945 protease TldD; Provisional; Region: tldD; PRK10735 243233000946 peptidase PmbA; Provisional; Region: PRK11040 243233000947 Competence-damaged protein; Region: CinA; pfam02464 243233000948 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 243233000949 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243233000950 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243233000951 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 243233000952 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243233000953 hexamer interface [polypeptide binding]; other site 243233000954 Walker A motif; other site 243233000955 ATP binding site [chemical binding]; other site 243233000956 Walker B motif; other site 243233000957 recombination regulator RecX; Reviewed; Region: recX; PRK00117 243233000958 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243233000959 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243233000960 motif 1; other site 243233000961 active site 243233000962 motif 2; other site 243233000963 motif 3; other site 243233000964 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243233000965 DHHA1 domain; Region: DHHA1; pfam02272 243233000966 aspartate kinase; Reviewed; Region: PRK06635 243233000967 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243233000968 putative nucleotide binding site [chemical binding]; other site 243233000969 putative catalytic residues [active] 243233000970 putative Mg ion binding site [ion binding]; other site 243233000971 putative aspartate binding site [chemical binding]; other site 243233000972 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243233000973 putative allosteric regulatory site; other site 243233000974 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 243233000975 carbon storage regulator; Provisional; Region: PRK01712 243233000976 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 243233000977 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 243233000978 RimM N-terminal domain; Region: RimM; pfam01782 243233000979 PRC-barrel domain; Region: PRC; pfam05239 243233000980 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243233000981 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243233000982 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 243233000983 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243233000984 active site 243233000985 Int/Topo IB signature motif; other site 243233000986 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243233000987 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243233000988 active site 243233000989 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243233000990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243233000991 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243233000992 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243233000993 inhibitor-cofactor binding pocket; inhibition site 243233000994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233000995 catalytic residue [active] 243233000996 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 243233000997 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 243233000998 transcription elongation factor regulatory protein; Validated; Region: PRK06342 243233000999 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243233001000 Protein of unknown function DUF45; Region: DUF45; pfam01863 243233001001 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 243233001002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233001003 catalytic residues [active] 243233001004 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243233001005 Sel1-like repeats; Region: SEL1; smart00671 243233001006 Sel1-like repeats; Region: SEL1; smart00671 243233001007 Sel1-like repeats; Region: SEL1; smart00671 243233001008 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 243233001009 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 243233001010 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 243233001011 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 243233001012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243233001013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243233001014 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233001015 Sporulation related domain; Region: SPOR; pfam05036 243233001016 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 243233001017 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 243233001018 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 243233001019 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 243233001020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233001021 TPR motif; other site 243233001022 binding surface 243233001023 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 243233001024 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 243233001025 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233001026 catalytic residues [active] 243233001027 central insert; other site 243233001028 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 243233001029 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 243233001030 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 243233001031 PKD domain; Region: PKD; pfam00801 243233001032 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243233001033 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243233001034 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243233001035 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243233001036 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243233001037 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243233001038 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 243233001039 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 243233001040 Flavodoxin; Region: Flavodoxin_1; pfam00258 243233001041 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 243233001042 FAD binding pocket [chemical binding]; other site 243233001043 FAD binding motif [chemical binding]; other site 243233001044 catalytic residues [active] 243233001045 NAD binding pocket [chemical binding]; other site 243233001046 phosphate binding motif [ion binding]; other site 243233001047 beta-alpha-beta structure motif; other site 243233001048 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243233001049 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243233001050 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 243233001051 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233001052 catalytic residues [active] 243233001053 central insert; other site 243233001054 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 243233001055 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243233001056 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243233001057 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233001058 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243233001059 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243233001060 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243233001061 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243233001062 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 243233001063 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243233001064 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243233001065 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243233001066 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233001067 TolR protein; Region: tolR; TIGR02801 243233001068 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243233001069 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243233001070 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243233001071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233001072 Walker A motif; other site 243233001073 ATP binding site [chemical binding]; other site 243233001074 Walker B motif; other site 243233001075 arginine finger; other site 243233001076 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 243233001077 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 243233001078 putative active site [active] 243233001079 putative metal binding site [ion binding]; other site 243233001080 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 243233001081 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243233001082 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 243233001083 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233001084 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243233001085 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243233001086 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243233001087 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 243233001088 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243233001089 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243233001090 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243233001091 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 243233001092 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233001093 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243233001094 Cache domain; Region: Cache_1; pfam02743 243233001095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243233001096 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243233001097 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 243233001098 CHASE domain; Region: CHASE; cl01369 243233001099 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233001100 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233001101 metal binding site [ion binding]; metal-binding site 243233001102 active site 243233001103 I-site; other site 243233001104 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 243233001105 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 243233001106 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243233001107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 243233001108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233001109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233001110 metal binding site [ion binding]; metal-binding site 243233001111 active site 243233001112 I-site; other site 243233001113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233001114 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 243233001115 homotrimer interface [polypeptide binding]; other site 243233001116 Walker A motif; other site 243233001117 GTP binding site [chemical binding]; other site 243233001118 Walker B motif; other site 243233001119 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 243233001120 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 243233001121 putative dimer interface [polypeptide binding]; other site 243233001122 active site pocket [active] 243233001123 putative cataytic base [active] 243233001124 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243233001125 catalytic core [active] 243233001126 cobalamin synthase; Reviewed; Region: cobS; PRK00235 243233001127 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 243233001128 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243233001129 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243233001130 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 243233001131 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243233001132 Protein of unknown function DUF58; Region: DUF58; pfam01882 243233001133 MoxR-like ATPases [General function prediction only]; Region: COG0714 243233001134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 243233001135 Walker A motif; other site 243233001136 ATP binding site [chemical binding]; other site 243233001137 Walker B motif; other site 243233001138 arginine finger; other site 243233001139 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 243233001140 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243233001141 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243233001142 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 243233001143 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243233001144 active site 243233001145 dimer interface [polypeptide binding]; other site 243233001146 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243233001147 Ligand Binding Site [chemical binding]; other site 243233001148 Molecular Tunnel; other site 243233001149 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243233001150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233001151 ATP binding site [chemical binding]; other site 243233001152 putative Mg++ binding site [ion binding]; other site 243233001153 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233001154 nucleotide binding region [chemical binding]; other site 243233001155 ATP-binding site [chemical binding]; other site 243233001156 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 243233001157 Part of AAA domain; Region: AAA_19; pfam13245 243233001158 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243233001159 Family description; Region: UvrD_C_2; pfam13538 243233001160 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 243233001161 putative active site [active] 243233001162 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 243233001163 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 243233001164 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 243233001165 Short C-terminal domain; Region: SHOCT; pfam09851 243233001166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233001167 S-adenosylmethionine binding site [chemical binding]; other site 243233001168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243233001169 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 243233001170 active site 243233001171 catalytic tetrad [active] 243233001172 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233001174 S-adenosylmethionine binding site [chemical binding]; other site 243233001175 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243233001176 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243233001177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233001178 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 243233001179 NAD(P) binding site [chemical binding]; other site 243233001180 active site 243233001181 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 243233001182 aromatic arch; other site 243233001183 DCoH dimer interaction site [polypeptide binding]; other site 243233001184 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 243233001185 DCoH tetramer interaction site [polypeptide binding]; other site 243233001186 substrate binding site [chemical binding]; other site 243233001187 NnrU protein; Region: NnrU; pfam07298 243233001188 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 243233001189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243233001190 active site 243233001191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233001192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233001193 metal binding site [ion binding]; metal-binding site 243233001194 active site 243233001195 I-site; other site 243233001196 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 243233001197 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 243233001198 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 243233001199 NADP binding site [chemical binding]; other site 243233001200 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243233001201 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243233001202 active site 243233001203 HIGH motif; other site 243233001204 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243233001205 KMSKS motif; other site 243233001206 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 243233001207 tRNA binding surface [nucleotide binding]; other site 243233001208 anticodon binding site; other site 243233001209 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243233001210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243233001211 active site 243233001212 HIGH motif; other site 243233001213 nucleotide binding site [chemical binding]; other site 243233001214 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243233001215 active site 243233001216 KMSKS motif; other site 243233001217 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243233001218 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233001219 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243233001220 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243233001221 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 243233001222 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243233001223 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233001224 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 243233001225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233001226 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 243233001227 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233001228 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243233001229 substrate binding site [chemical binding]; other site 243233001230 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 243233001231 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 243233001232 active site 243233001233 nucleotide binding site [chemical binding]; other site 243233001234 HIGH motif; other site 243233001235 KMSKS motif; other site 243233001236 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 243233001237 nudix motif; other site 243233001238 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 243233001239 hypothetical protein; Provisional; Region: PRK05170 243233001240 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 243233001241 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 243233001242 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243233001243 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 243233001244 active site 243233001245 intersubunit interface [polypeptide binding]; other site 243233001246 Zn2+ binding site [ion binding]; other site 243233001247 CAAX protease self-immunity; Region: Abi; pfam02517 243233001248 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243233001249 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 243233001250 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243233001251 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 243233001252 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243233001253 oligomer interface [polypeptide binding]; other site 243233001254 active site residues [active] 243233001255 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243233001256 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243233001257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233001258 Walker A motif; other site 243233001259 ATP binding site [chemical binding]; other site 243233001260 Walker B motif; other site 243233001261 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243233001262 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243233001263 Found in ATP-dependent protease La (LON); Region: LON; smart00464 243233001264 Found in ATP-dependent protease La (LON); Region: LON; smart00464 243233001265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233001266 Walker A motif; other site 243233001267 ATP binding site [chemical binding]; other site 243233001268 Walker B motif; other site 243233001269 arginine finger; other site 243233001270 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243233001271 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243233001272 IHF dimer interface [polypeptide binding]; other site 243233001273 IHF - DNA interface [nucleotide binding]; other site 243233001274 periplasmic folding chaperone; Provisional; Region: PRK10788 243233001275 SurA N-terminal domain; Region: SurA_N_3; cl07813 243233001276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243233001277 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 243233001278 GTPase RsgA; Reviewed; Region: PRK00098 243233001279 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243233001280 RNA binding site [nucleotide binding]; other site 243233001281 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243233001282 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243233001283 GTP/Mg2+ binding site [chemical binding]; other site 243233001284 G4 box; other site 243233001285 G5 box; other site 243233001286 G1 box; other site 243233001287 Switch I region; other site 243233001288 G2 box; other site 243233001289 G3 box; other site 243233001290 Switch II region; other site 243233001291 Peptidase family M48; Region: Peptidase_M48; pfam01435 243233001292 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 243233001293 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 243233001294 catalytic site [active] 243233001295 putative active site [active] 243233001296 putative substrate binding site [chemical binding]; other site 243233001297 dimer interface [polypeptide binding]; other site 243233001298 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243233001299 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 243233001300 putative NAD(P) binding site [chemical binding]; other site 243233001301 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243233001302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233001303 putative ADP-binding pocket [chemical binding]; other site 243233001304 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243233001305 active site 243233001306 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 243233001307 dimer interface [polypeptide binding]; other site 243233001308 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243233001309 Ligand Binding Site [chemical binding]; other site 243233001310 Molecular Tunnel; other site 243233001311 elongation factor G; Reviewed; Region: PRK00007 243233001312 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243233001313 G1 box; other site 243233001314 putative GEF interaction site [polypeptide binding]; other site 243233001315 GTP/Mg2+ binding site [chemical binding]; other site 243233001316 Switch I region; other site 243233001317 G2 box; other site 243233001318 G3 box; other site 243233001319 Switch II region; other site 243233001320 G4 box; other site 243233001321 G5 box; other site 243233001322 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243233001323 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243233001324 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243233001325 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 243233001326 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243233001327 PAS domain S-box; Region: sensory_box; TIGR00229 243233001328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233001329 putative active site [active] 243233001330 heme pocket [chemical binding]; other site 243233001331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233001332 PAS domain; Region: PAS_9; pfam13426 243233001333 putative active site [active] 243233001334 heme pocket [chemical binding]; other site 243233001335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233001336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233001337 metal binding site [ion binding]; metal-binding site 243233001338 active site 243233001339 I-site; other site 243233001340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233001341 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 243233001342 pseudouridine synthase; Region: TIGR00093 243233001343 probable active site [active] 243233001344 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 243233001345 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243233001346 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 243233001347 DNA methylase; Region: N6_N4_Mtase; pfam01555 243233001348 DNA methylase; Region: N6_N4_Mtase; pfam01555 243233001349 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 243233001350 putative active site [active] 243233001351 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 243233001352 head completion protein; Provisional; Region: 4; PHA02552 243233001353 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 243233001354 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 243233001355 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233001356 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243233001357 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243233001358 Walker A/P-loop; other site 243233001359 ATP binding site [chemical binding]; other site 243233001360 Q-loop/lid; other site 243233001361 ABC transporter signature motif; other site 243233001362 Walker B; other site 243233001363 D-loop; other site 243233001364 H-loop/switch region; other site 243233001365 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 243233001366 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243233001367 Walker A/P-loop; other site 243233001368 ATP binding site [chemical binding]; other site 243233001369 Q-loop/lid; other site 243233001370 ABC transporter signature motif; other site 243233001371 Walker B; other site 243233001372 D-loop; other site 243233001373 H-loop/switch region; other site 243233001374 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243233001375 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 243233001376 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243233001377 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243233001378 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 243233001379 Uncharacterized conserved protein [Function unknown]; Region: COG0432 243233001380 Predicted metal-binding protein [General function prediction only]; Region: COG3019 243233001381 glucokinase, proteobacterial type; Region: glk; TIGR00749 243233001382 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243233001383 nucleotide binding site [chemical binding]; other site 243233001384 Protein required for attachment to host cells; Region: Host_attach; pfam10116 243233001385 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 243233001386 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 243233001387 hexamer interface [polypeptide binding]; other site 243233001388 ligand binding site [chemical binding]; other site 243233001389 putative active site [active] 243233001390 NAD(P) binding site [chemical binding]; other site 243233001391 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 243233001392 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243233001393 metal binding triad; other site 243233001394 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243233001395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243233001396 Zn2+ binding site [ion binding]; other site 243233001397 Mg2+ binding site [ion binding]; other site 243233001398 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 243233001399 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 243233001400 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243233001401 active site 243233001402 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243233001403 rRNA interaction site [nucleotide binding]; other site 243233001404 S8 interaction site; other site 243233001405 putative laminin-1 binding site; other site 243233001406 elongation factor Ts; Provisional; Region: tsf; PRK09377 243233001407 UBA/TS-N domain; Region: UBA; pfam00627 243233001408 Elongation factor TS; Region: EF_TS; pfam00889 243233001409 Elongation factor TS; Region: EF_TS; pfam00889 243233001410 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243233001411 putative nucleotide binding site [chemical binding]; other site 243233001412 uridine monophosphate binding site [chemical binding]; other site 243233001413 homohexameric interface [polypeptide binding]; other site 243233001414 ribosome recycling factor; Reviewed; Region: frr; PRK00083 243233001415 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243233001416 hinge region; other site 243233001417 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 243233001418 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 243233001419 catalytic residue [active] 243233001420 putative FPP diphosphate binding site; other site 243233001421 putative FPP binding hydrophobic cleft; other site 243233001422 dimer interface [polypeptide binding]; other site 243233001423 putative IPP diphosphate binding site; other site 243233001424 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 243233001425 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243233001426 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 243233001427 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243233001428 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243233001429 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243233001430 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243233001431 zinc metallopeptidase RseP; Provisional; Region: PRK10779 243233001432 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243233001433 protein binding site [polypeptide binding]; other site 243233001434 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 243233001435 putative substrate binding region [chemical binding]; other site 243233001436 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 243233001437 dimerization domain [polypeptide binding]; other site 243233001438 dimer interface [polypeptide binding]; other site 243233001439 catalytic residues [active] 243233001440 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 243233001441 MutS domain I; Region: MutS_I; pfam01624 243233001442 MutS domain II; Region: MutS_II; pfam05188 243233001443 MutS domain III; Region: MutS_III; pfam05192 243233001444 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 243233001445 Walker A/P-loop; other site 243233001446 ATP binding site [chemical binding]; other site 243233001447 Q-loop/lid; other site 243233001448 ABC transporter signature motif; other site 243233001449 Walker B; other site 243233001450 D-loop; other site 243233001451 H-loop/switch region; other site 243233001452 Cupin domain; Region: Cupin_2; cl17218 243233001453 Domain of unknown function DUF29; Region: DUF29; pfam01724 243233001454 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243233001455 FOG: CBS domain [General function prediction only]; Region: COG0517 243233001456 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 243233001457 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 243233001458 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243233001459 DNA binding site [nucleotide binding] 243233001460 active site 243233001461 hypothetical protein; Validated; Region: PRK00029 243233001462 Uncharacterized conserved protein [Function unknown]; Region: COG0397 243233001463 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243233001464 iron-sulfur cluster [ion binding]; other site 243233001465 [2Fe-2S] cluster binding site [ion binding]; other site 243233001466 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 243233001467 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243233001468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233001469 active site 243233001470 phosphorylation site [posttranslational modification] 243233001471 intermolecular recognition site; other site 243233001472 dimerization interface [polypeptide binding]; other site 243233001473 ANTAR domain; Region: ANTAR; pfam03861 243233001474 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243233001475 NMT1-like family; Region: NMT1_2; pfam13379 243233001476 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243233001477 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 243233001478 [4Fe-4S] binding site [ion binding]; other site 243233001479 molybdopterin cofactor binding site; other site 243233001480 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 243233001481 molybdopterin cofactor binding site; other site 243233001482 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243233001483 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 243233001484 [2Fe-2S] cluster binding site [ion binding]; other site 243233001485 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 243233001486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233001487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233001488 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243233001489 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243233001490 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243233001491 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 243233001492 active site 243233001493 Protein kinase domain; Region: Pkinase; pfam00069 243233001494 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243233001495 active site 243233001496 ATP binding site [chemical binding]; other site 243233001497 substrate binding site [chemical binding]; other site 243233001498 activation loop (A-loop); other site 243233001499 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 243233001500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233001501 putative substrate translocation pore; other site 243233001502 threonine synthase; Reviewed; Region: PRK06721 243233001503 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 243233001504 homodimer interface [polypeptide binding]; other site 243233001505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233001506 catalytic residue [active] 243233001507 homoserine dehydrogenase; Provisional; Region: PRK06349 243233001508 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243233001509 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243233001510 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243233001511 aminotransferase; Validated; Region: PRK08175 243233001512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233001513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233001514 homodimer interface [polypeptide binding]; other site 243233001515 catalytic residue [active] 243233001516 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243233001517 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 243233001518 Substrate binding site; other site 243233001519 metal-binding site 243233001520 Phosphotransferase enzyme family; Region: APH; pfam01636 243233001521 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243233001522 active site 243233001523 substrate binding site [chemical binding]; other site 243233001524 ATP binding site [chemical binding]; other site 243233001525 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 243233001526 substrate binding site [chemical binding]; other site 243233001527 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 243233001528 Organic solvent tolerance protein; Region: OstA_C; pfam04453 243233001529 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 243233001530 SurA N-terminal domain; Region: SurA_N; pfam09312 243233001531 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243233001532 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243233001533 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 243233001534 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 243233001535 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243233001536 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 243233001537 S-adenosylmethionine binding site [chemical binding]; other site 243233001538 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233001539 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 243233001540 phosphoglucomutase; Region: PLN02307 243233001541 active site 243233001542 substrate binding site [chemical binding]; other site 243233001543 metal binding site [ion binding]; metal-binding site 243233001544 MEKHLA domain; Region: MEKHLA; pfam08670 243233001545 ABC transporter ATPase component; Reviewed; Region: PRK11147 243233001546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233001547 Walker A/P-loop; other site 243233001548 ATP binding site [chemical binding]; other site 243233001549 Q-loop/lid; other site 243233001550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233001551 ABC transporter; Region: ABC_tran_2; pfam12848 243233001552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233001553 malate dehydrogenase; Provisional; Region: PRK05442 243233001554 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 243233001555 NAD(P) binding site [chemical binding]; other site 243233001556 dimer interface [polypeptide binding]; other site 243233001557 malate binding site [chemical binding]; other site 243233001558 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243233001559 metal-binding site [ion binding] 243233001560 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243233001561 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 243233001562 putative NAD(P) binding site [chemical binding]; other site 243233001563 active site 243233001564 putative substrate binding site [chemical binding]; other site 243233001565 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 243233001566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233001567 putative ADP-binding pocket [chemical binding]; other site 243233001568 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 243233001569 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 243233001570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233001571 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233001572 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243233001573 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243233001574 Probable Catalytic site; other site 243233001575 metal-binding site 243233001576 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233001577 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233001578 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243233001579 Probable Catalytic site; other site 243233001580 metal-binding site 243233001581 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233001582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233001583 active site 243233001584 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233001585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233001586 active site 243233001587 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 243233001588 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 243233001589 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 243233001590 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243233001591 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243233001592 Walker A/P-loop; other site 243233001593 ATP binding site [chemical binding]; other site 243233001594 Q-loop/lid; other site 243233001595 ABC transporter signature motif; other site 243233001596 Walker B; other site 243233001597 D-loop; other site 243233001598 H-loop/switch region; other site 243233001599 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243233001600 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243233001601 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 243233001602 DHH family; Region: DHH; pfam01368 243233001603 DHHA1 domain; Region: DHHA1; pfam02272 243233001604 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243233001605 dimer interface [polypeptide binding]; other site 243233001606 substrate binding site [chemical binding]; other site 243233001607 ATP binding site [chemical binding]; other site 243233001608 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243233001609 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233001610 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243233001611 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 243233001612 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 243233001613 Uncharacterized conserved protein [Function unknown]; Region: COG2835 243233001614 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 243233001615 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 243233001616 Ligand binding site; other site 243233001617 oligomer interface; other site 243233001618 Predicted membrane protein [Function unknown]; Region: COG1238 243233001619 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233001620 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 243233001621 putative amphipathic alpha helix; other site 243233001622 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 243233001623 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 243233001624 FMN binding site [chemical binding]; other site 243233001625 active site 243233001626 substrate binding site [chemical binding]; other site 243233001627 catalytic residue [active] 243233001628 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 243233001629 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 243233001630 Ion channel; Region: Ion_trans_2; pfam07885 243233001631 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 243233001632 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 243233001633 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 243233001634 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 243233001635 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 243233001636 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 243233001637 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 243233001638 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 243233001639 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 243233001640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233001641 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 243233001642 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243233001643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243233001644 fructokinase; Reviewed; Region: PRK09557 243233001645 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243233001646 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243233001647 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 243233001648 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 243233001649 putative active site [active] 243233001650 PhoH-like protein; Region: PhoH; pfam02562 243233001651 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243233001652 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233001653 catalytic triad [active] 243233001654 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 243233001655 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 243233001656 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 243233001657 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 243233001658 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 243233001659 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243233001660 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243233001661 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243233001662 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243233001663 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233001664 TolR protein; Region: tolR; TIGR02801 243233001665 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243233001666 dihydrodipicolinate synthase; Region: dapA; TIGR00674 243233001667 dimer interface [polypeptide binding]; other site 243233001668 active site 243233001669 catalytic residue [active] 243233001670 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 243233001671 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 243233001672 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243233001673 dimerization interface [polypeptide binding]; other site 243233001674 ATP binding site [chemical binding]; other site 243233001675 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243233001676 dimerization interface [polypeptide binding]; other site 243233001677 ATP binding site [chemical binding]; other site 243233001678 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 243233001679 putative active site [active] 243233001680 catalytic triad [active] 243233001681 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243233001682 triosephosphate isomerase; Provisional; Region: PRK14567 243233001683 substrate binding site [chemical binding]; other site 243233001684 dimer interface [polypeptide binding]; other site 243233001685 catalytic triad [active] 243233001686 Preprotein translocase SecG subunit; Region: SecG; pfam03840 243233001687 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 243233001688 Domain of unknown function (DUF955); Region: DUF955; pfam06114 243233001689 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243233001690 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243233001691 Preprotein translocase subunit; Region: YajC; cl00806 243233001692 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 243233001693 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243233001694 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243233001695 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 243233001696 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 243233001697 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 243233001698 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243233001699 Protein export membrane protein; Region: SecD_SecF; pfam02355 243233001700 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233001701 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 243233001702 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 243233001703 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 243233001704 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 243233001705 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 243233001706 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 243233001707 Family description; Region: UvrD_C_2; pfam13538 243233001708 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 243233001709 AAA domain; Region: AAA_30; pfam13604 243233001710 Family description; Region: UvrD_C_2; pfam13538 243233001711 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 243233001712 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 243233001713 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243233001714 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243233001715 active site 243233001716 dimer interface [polypeptide binding]; other site 243233001717 motif 1; other site 243233001718 motif 2; other site 243233001719 motif 3; other site 243233001720 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243233001721 anticodon binding site; other site 243233001722 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243233001723 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243233001724 23S rRNA binding site [nucleotide binding]; other site 243233001725 L21 binding site [polypeptide binding]; other site 243233001726 L13 binding site [polypeptide binding]; other site 243233001727 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243233001728 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243233001729 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243233001730 dimer interface [polypeptide binding]; other site 243233001731 motif 1; other site 243233001732 active site 243233001733 motif 2; other site 243233001734 motif 3; other site 243233001735 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 243233001736 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243233001737 putative tRNA-binding site [nucleotide binding]; other site 243233001738 B3/4 domain; Region: B3_4; pfam03483 243233001739 tRNA synthetase B5 domain; Region: B5; smart00874 243233001740 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243233001741 dimer interface [polypeptide binding]; other site 243233001742 motif 1; other site 243233001743 motif 3; other site 243233001744 motif 2; other site 243233001745 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 243233001746 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243233001747 IHF - DNA interface [nucleotide binding]; other site 243233001748 IHF dimer interface [polypeptide binding]; other site 243233001749 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 243233001750 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243233001751 HemK family putative methylases; Region: hemK_fam; TIGR00536 243233001752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233001753 S-adenosylmethionine binding site [chemical binding]; other site 243233001754 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 243233001755 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 243233001756 Tetramer interface [polypeptide binding]; other site 243233001757 active site 243233001758 FMN-binding site [chemical binding]; other site 243233001759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233001760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243233001761 putative substrate translocation pore; other site 243233001762 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243233001763 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243233001764 metal-binding site [ion binding] 243233001765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233001766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243233001767 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243233001768 oligomerisation interface [polypeptide binding]; other site 243233001769 mobile loop; other site 243233001770 roof hairpin; other site 243233001771 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243233001772 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243233001773 ring oligomerisation interface [polypeptide binding]; other site 243233001774 ATP/Mg binding site [chemical binding]; other site 243233001775 stacking interactions; other site 243233001776 hinge regions; other site 243233001777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233001778 active site 243233001779 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 243233001780 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233001781 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233001782 catalytic residue [active] 243233001783 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243233001784 Transcriptional regulator; Region: Rrf2; cl17282 243233001785 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 243233001786 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 243233001787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233001788 Acylphosphatase; Region: Acylphosphatase; pfam00708 243233001789 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 243233001790 Hemerythrin; Region: Hemerythrin; cd12107 243233001791 Fe binding site [ion binding]; other site 243233001792 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030 243233001793 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243233001794 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243233001795 RNA/DNA hybrid binding site [nucleotide binding]; other site 243233001796 active site 243233001797 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 243233001798 active site 243233001799 catalytic site [active] 243233001800 substrate binding site [chemical binding]; other site 243233001801 Transposase domain (DUF772); Region: DUF772; pfam05598 243233001802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233001803 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233001804 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243233001805 FAD binding domain; Region: FAD_binding_3; pfam01494 243233001806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243233001807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243233001808 Nuclease-related domain; Region: NERD; pfam08378 243233001809 Part of AAA domain; Region: AAA_19; pfam13245 243233001810 Family description; Region: UvrD_C_2; pfam13538 243233001811 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 243233001812 Integrase core domain; Region: rve; pfam00665 243233001813 Integrase core domain; Region: rve_3; pfam13683 243233001814 putative transposase OrfB; Reviewed; Region: PHA02517 243233001815 HTH-like domain; Region: HTH_21; pfam13276 243233001816 Integrase core domain; Region: rve; pfam00665 243233001817 Integrase core domain; Region: rve_3; pfam13683 243233001818 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 243233001819 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243233001820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233001821 FeS/SAM binding site; other site 243233001822 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 243233001823 AAA domain; Region: AAA_33; pfam13671 243233001824 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243233001825 30S subunit binding site; other site 243233001826 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 243233001827 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 243233001828 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 243233001829 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 243233001830 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 243233001831 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 243233001832 Walker A/P-loop; other site 243233001833 ATP binding site [chemical binding]; other site 243233001834 Q-loop/lid; other site 243233001835 ABC transporter signature motif; other site 243233001836 Walker B; other site 243233001837 D-loop; other site 243233001838 H-loop/switch region; other site 243233001839 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 243233001840 OstA-like protein; Region: OstA; pfam03968 243233001841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 243233001842 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 243233001843 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 243233001844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233001845 active site 243233001846 motif I; other site 243233001847 motif II; other site 243233001848 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 243233001849 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 243233001850 putative active site [active] 243233001851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 243233001852 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243233001853 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 243233001854 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 243233001855 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243233001856 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243233001857 active site 243233001858 HIGH motif; other site 243233001859 dimer interface [polypeptide binding]; other site 243233001860 KMSKS motif; other site 243233001861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243233001862 RNA binding surface [nucleotide binding]; other site 243233001863 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PLN02538 243233001864 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 243233001865 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243233001866 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243233001867 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 243233001868 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 243233001869 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 243233001870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233001871 catalytic loop [active] 243233001872 iron binding site [ion binding]; other site 243233001873 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 243233001874 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 243233001875 heme binding site [chemical binding]; other site 243233001876 ferroxidase pore; other site 243233001877 ferroxidase diiron center [ion binding]; other site 243233001878 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 243233001879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233001880 putative active site [active] 243233001881 heme pocket [chemical binding]; other site 243233001882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233001883 ATP binding site [chemical binding]; other site 243233001884 Mg2+ binding site [ion binding]; other site 243233001885 G-X-G motif; other site 243233001886 Nif-specific regulatory protein; Region: nifA; TIGR01817 243233001887 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243233001888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233001889 Walker A motif; other site 243233001890 ATP binding site [chemical binding]; other site 243233001891 Walker B motif; other site 243233001892 arginine finger; other site 243233001893 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233001894 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 243233001895 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243233001896 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 243233001897 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 243233001898 putative active site [active] 243233001899 putative FMN binding site [chemical binding]; other site 243233001900 putative substrate binding site [chemical binding]; other site 243233001901 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 243233001902 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243233001903 dimer interface [polypeptide binding]; other site 243233001904 PYR/PP interface [polypeptide binding]; other site 243233001905 TPP binding site [chemical binding]; other site 243233001906 substrate binding site [chemical binding]; other site 243233001907 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 243233001908 Domain of unknown function; Region: EKR; pfam10371 243233001909 4Fe-4S binding domain; Region: Fer4_6; pfam12837 243233001910 4Fe-4S binding domain; Region: Fer4; pfam00037 243233001911 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 243233001912 TPP-binding site [chemical binding]; other site 243233001913 dimer interface [polypeptide binding]; other site 243233001914 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 243233001915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233001916 4Fe-4S binding domain; Region: Fer4; pfam00037 243233001917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233001918 dimerization interface [polypeptide binding]; other site 243233001919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233001920 dimer interface [polypeptide binding]; other site 243233001921 phosphorylation site [posttranslational modification] 243233001922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233001923 ATP binding site [chemical binding]; other site 243233001924 Mg2+ binding site [ion binding]; other site 243233001925 G-X-G motif; other site 243233001926 osmolarity response regulator; Provisional; Region: ompR; PRK09468 243233001927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233001928 active site 243233001929 phosphorylation site [posttranslational modification] 243233001930 intermolecular recognition site; other site 243233001931 dimerization interface [polypeptide binding]; other site 243233001932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233001933 DNA binding site [nucleotide binding] 243233001934 aminopeptidase N; Provisional; Region: pepN; PRK14015 243233001935 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 243233001936 active site 243233001937 Zn binding site [ion binding]; other site 243233001938 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243233001939 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 243233001940 putative NAD(P) binding site [chemical binding]; other site 243233001941 putative substrate binding site [chemical binding]; other site 243233001942 catalytic Zn binding site [ion binding]; other site 243233001943 structural Zn binding site [ion binding]; other site 243233001944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243233001945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233001946 active site 243233001947 phosphorylation site [posttranslational modification] 243233001948 intermolecular recognition site; other site 243233001949 dimerization interface [polypeptide binding]; other site 243233001950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243233001951 DNA binding residues [nucleotide binding] 243233001952 dimerization interface [polypeptide binding]; other site 243233001953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233001954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243233001955 Histidine kinase; Region: HisKA_3; pfam07730 243233001956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233001957 ATP binding site [chemical binding]; other site 243233001958 Mg2+ binding site [ion binding]; other site 243233001959 G-X-G motif; other site 243233001960 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 243233001961 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 243233001962 Trp docking motif [polypeptide binding]; other site 243233001963 dimer interface [polypeptide binding]; other site 243233001964 active site 243233001965 small subunit binding site [polypeptide binding]; other site 243233001966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243233001967 membrane-bound complex binding site; other site 243233001968 hinge residues; other site 243233001969 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 243233001970 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 243233001971 MoxR-like ATPases [General function prediction only]; Region: COG0714 243233001972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233001973 Walker A motif; other site 243233001974 ATP binding site [chemical binding]; other site 243233001975 Walker B motif; other site 243233001976 arginine finger; other site 243233001977 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243233001978 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243233001979 metal ion-dependent adhesion site (MIDAS); other site 243233001980 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243233001981 metal ion-dependent adhesion site (MIDAS); other site 243233001982 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243233001983 putative hydrophobic ligand binding site [chemical binding]; other site 243233001984 protein interface [polypeptide binding]; other site 243233001985 gate; other site 243233001986 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243233001987 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 243233001988 transmembrane helices; other site 243233001989 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243233001990 DNA-binding site [nucleotide binding]; DNA binding site 243233001991 RNA-binding motif; other site 243233001992 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 243233001993 RNA recognition motif; Region: RRM; smart00360 243233001994 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 243233001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 243233001996 Peptidase M15; Region: Peptidase_M15_3; cl01194 243233001997 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 243233001998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233001999 motif II; other site 243233002000 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 243233002001 Cupin domain; Region: Cupin_2; pfam07883 243233002002 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 243233002003 intersubunit interface [polypeptide binding]; other site 243233002004 active site 243233002005 Zn2+ binding site [ion binding]; other site 243233002006 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243233002007 Family description; Region: DsbD_2; pfam13386 243233002008 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 243233002009 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 243233002010 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243233002011 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243233002012 metal-binding site [ion binding] 243233002013 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233002014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233002015 motif II; other site 243233002016 hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481 243233002017 Copper resistance protein D; Region: CopD; cl00563 243233002018 CopC domain; Region: CopC; cl01012 243233002019 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 243233002020 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243233002021 inhibitor-cofactor binding pocket; inhibition site 243233002022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233002023 catalytic residue [active] 243233002024 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243233002025 Protein export membrane protein; Region: SecD_SecF; cl14618 243233002026 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 243233002027 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 243233002028 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 243233002029 Active site cavity [active] 243233002030 catalytic acid [active] 243233002031 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 243233002032 active site lid residues [active] 243233002033 substrate binding pocket [chemical binding]; other site 243233002034 catalytic residues [active] 243233002035 substrate-Mg2+ binding site; other site 243233002036 aspartate-rich region 1; other site 243233002037 aspartate-rich region 2; other site 243233002038 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 243233002039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233002040 FeS/SAM binding site; other site 243233002041 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 243233002042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233002043 active site 243233002044 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243233002045 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243233002046 TPP-binding site; other site 243233002047 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243233002048 PYR/PP interface [polypeptide binding]; other site 243233002049 dimer interface [polypeptide binding]; other site 243233002050 TPP binding site [chemical binding]; other site 243233002051 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243233002052 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243233002053 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243233002054 substrate binding pocket [chemical binding]; other site 243233002055 chain length determination region; other site 243233002056 substrate-Mg2+ binding site; other site 243233002057 catalytic residues [active] 243233002058 aspartate-rich region 1; other site 243233002059 active site lid residues [active] 243233002060 aspartate-rich region 2; other site 243233002061 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 243233002062 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 243233002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233002064 Mg2+ binding site [ion binding]; other site 243233002065 G-X-G motif; other site 243233002066 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243233002067 anchoring element; other site 243233002068 dimer interface [polypeptide binding]; other site 243233002069 ATP binding site [chemical binding]; other site 243233002070 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 243233002071 active site 243233002072 metal binding site [ion binding]; metal-binding site 243233002073 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243233002074 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 243233002075 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243233002076 CAP-like domain; other site 243233002077 active site 243233002078 primary dimer interface [polypeptide binding]; other site 243233002079 Putative transposase; Region: Y2_Tnp; pfam04986 243233002080 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243233002081 HTH-like domain; Region: HTH_21; pfam13276 243233002082 Integrase core domain; Region: rve; pfam00665 243233002083 Integrase core domain; Region: rve_3; pfam13683 243233002084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233002085 Helix-turn-helix domain; Region: HTH_18; pfam12833 243233002086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233002087 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243233002088 putative hydrophobic ligand binding site [chemical binding]; other site 243233002089 protein interface [polypeptide binding]; other site 243233002090 gate; other site 243233002091 5'-nucleotidase; Provisional; Region: PRK03826 243233002092 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 243233002093 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243233002094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233002095 S-adenosylmethionine binding site [chemical binding]; other site 243233002096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233002097 TPR motif; other site 243233002098 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243233002099 binding surface 243233002100 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 243233002101 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243233002102 putative binding surface; other site 243233002103 active site 243233002104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233002105 ATP binding site [chemical binding]; other site 243233002106 Mg2+ binding site [ion binding]; other site 243233002107 G-X-G motif; other site 243233002108 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 243233002109 Response regulator receiver domain; Region: Response_reg; pfam00072 243233002110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233002111 active site 243233002112 phosphorylation site [posttranslational modification] 243233002113 intermolecular recognition site; other site 243233002114 dimerization interface [polypeptide binding]; other site 243233002115 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 243233002116 cheY-homologous receiver domain; Region: REC; smart00448 243233002117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233002118 phosphorylation site [posttranslational modification] 243233002119 intermolecular recognition site; other site 243233002120 CheB methylesterase; Region: CheB_methylest; pfam01339 243233002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233002122 active site 243233002123 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243233002124 phosphorylation site [posttranslational modification] 243233002125 intermolecular recognition site; other site 243233002126 dimerization interface [polypeptide binding]; other site 243233002127 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243233002128 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 243233002129 Fic family protein [Function unknown]; Region: COG3177 243233002130 Fic/DOC family; Region: Fic; pfam02661 243233002131 MarR family; Region: MarR_2; cl17246 243233002132 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243233002133 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243233002134 Transposase IS200 like; Region: Y1_Tnp; cl00848 243233002135 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 243233002136 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243233002137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233002138 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 243233002139 GIY-YIG motif/motif A; other site 243233002140 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 243233002141 active site 243233002142 catalytic site [active] 243233002143 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 243233002144 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 243233002145 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243233002146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243233002147 substrate binding pocket [chemical binding]; other site 243233002148 membrane-bound complex binding site; other site 243233002149 hinge residues; other site 243233002150 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 243233002151 catalytic residues [active] 243233002152 dimer interface [polypeptide binding]; other site 243233002153 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233002154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233002155 metal binding site [ion binding]; metal-binding site 243233002156 active site 243233002157 I-site; other site 243233002158 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 243233002159 TMAO/DMSO reductase; Reviewed; Region: PRK05363 243233002160 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243233002161 Moco binding site; other site 243233002162 metal coordination site [ion binding]; other site 243233002163 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 243233002164 dimer interface [polypeptide binding]; other site 243233002165 Citrate synthase; Region: Citrate_synt; pfam00285 243233002166 active site 243233002167 citrylCoA binding site [chemical binding]; other site 243233002168 NADH binding [chemical binding]; other site 243233002169 cationic pore residues; other site 243233002170 oxalacetate/citrate binding site [chemical binding]; other site 243233002171 coenzyme A binding site [chemical binding]; other site 243233002172 catalytic triad [active] 243233002173 heat shock protein 90; Provisional; Region: PRK05218 243233002174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233002175 ATP binding site [chemical binding]; other site 243233002176 Mg2+ binding site [ion binding]; other site 243233002177 G-X-G motif; other site 243233002178 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 243233002179 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243233002180 FtsH Extracellular; Region: FtsH_ext; pfam06480 243233002181 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243233002182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233002183 Walker A motif; other site 243233002184 ATP binding site [chemical binding]; other site 243233002185 Walker B motif; other site 243233002186 arginine finger; other site 243233002187 Peptidase family M41; Region: Peptidase_M41; pfam01434 243233002188 AAA domain; Region: AAA_32; pfam13654 243233002189 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 243233002190 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 243233002191 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243233002192 Putative exonuclease, RdgC; Region: RdgC; pfam04381 243233002193 L,D-transpeptidase; Provisional; Region: PRK10260 243233002194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243233002195 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233002196 oxidative damage protection protein; Provisional; Region: PRK05408 243233002197 adenine DNA glycosylase; Provisional; Region: PRK10880 243233002198 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243233002199 minor groove reading motif; other site 243233002200 helix-hairpin-helix signature motif; other site 243233002201 substrate binding pocket [chemical binding]; other site 243233002202 active site 243233002203 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 243233002204 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 243233002205 DNA binding and oxoG recognition site [nucleotide binding] 243233002206 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243233002207 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243233002208 active site 243233002209 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243233002210 substrate binding site [chemical binding]; other site 243233002211 catalytic residues [active] 243233002212 dimer interface [polypeptide binding]; other site 243233002213 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 243233002214 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243233002215 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243233002216 Protein of unknown function, DUF484; Region: DUF484; cl17449 243233002217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243233002218 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243233002219 active site 243233002220 DNA binding site [nucleotide binding] 243233002221 Int/Topo IB signature motif; other site 243233002222 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 243233002223 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 243233002224 hypothetical protein; Provisional; Region: PRK05255 243233002225 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 243233002226 B12 binding domain; Region: B12-binding; pfam02310 243233002227 B12 binding site [chemical binding]; other site 243233002228 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243233002229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233002230 FeS/SAM binding site; other site 243233002231 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 243233002232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 243233002233 Smr domain; Region: Smr; pfam01713 243233002234 Phosphotransferase enzyme family; Region: APH; pfam01636 243233002235 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243233002236 active site 243233002237 substrate binding site [chemical binding]; other site 243233002238 ATP binding site [chemical binding]; other site 243233002239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243233002240 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 243233002241 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 243233002242 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 243233002243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233002244 dimer interface [polypeptide binding]; other site 243233002245 conserved gate region; other site 243233002246 putative PBP binding loops; other site 243233002247 ABC-ATPase subunit interface; other site 243233002248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233002249 putative PBP binding loops; other site 243233002250 ABC-ATPase subunit interface; other site 243233002251 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 243233002252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233002253 Walker A/P-loop; other site 243233002254 ATP binding site [chemical binding]; other site 243233002255 Q-loop/lid; other site 243233002256 ABC transporter signature motif; other site 243233002257 Walker B; other site 243233002258 D-loop; other site 243233002259 H-loop/switch region; other site 243233002260 TOBE domain; Region: TOBE; pfam03459 243233002261 TOBE domain; Region: TOBE_2; pfam08402 243233002262 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 243233002263 Sel1-like repeats; Region: SEL1; smart00671 243233002264 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243233002265 Sel1-like repeats; Region: SEL1; smart00671 243233002266 Sel1-like repeats; Region: SEL1; smart00671 243233002267 Sel1-like repeats; Region: SEL1; smart00671 243233002268 Sel1-like repeats; Region: SEL1; smart00671 243233002269 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 243233002270 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 243233002271 calcium binding site 2 [ion binding]; other site 243233002272 active site 243233002273 catalytic triad [active] 243233002274 calcium binding site 1 [ion binding]; other site 243233002275 PrcB C-terminal; Region: PrcB_C; pfam14343 243233002276 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 243233002277 active site 243233002278 catalytic site [active] 243233002279 substrate binding site [chemical binding]; other site 243233002280 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 243233002281 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 243233002282 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 243233002283 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243233002284 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243233002285 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 243233002286 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 243233002287 Subunit I/III interface [polypeptide binding]; other site 243233002288 D-pathway; other site 243233002289 Subunit I/VIIc interface [polypeptide binding]; other site 243233002290 Subunit I/IV interface [polypeptide binding]; other site 243233002291 Subunit I/II interface [polypeptide binding]; other site 243233002292 Low-spin heme (heme a) binding site [chemical binding]; other site 243233002293 Subunit I/VIIa interface [polypeptide binding]; other site 243233002294 Subunit I/VIa interface [polypeptide binding]; other site 243233002295 Dimer interface; other site 243233002296 Putative water exit pathway; other site 243233002297 Binuclear center (heme a3/CuB) [ion binding]; other site 243233002298 K-pathway; other site 243233002299 Subunit I/Vb interface [polypeptide binding]; other site 243233002300 Putative proton exit pathway; other site 243233002301 Subunit I/VIb interface; other site 243233002302 Subunit I/VIc interface [polypeptide binding]; other site 243233002303 Electron transfer pathway; other site 243233002304 Subunit I/VIIIb interface [polypeptide binding]; other site 243233002305 Subunit I/VIIb interface [polypeptide binding]; other site 243233002306 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 243233002307 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 243233002308 Subunit III/VIIa interface [polypeptide binding]; other site 243233002309 Phospholipid binding site [chemical binding]; other site 243233002310 Subunit I/III interface [polypeptide binding]; other site 243233002311 Subunit III/VIb interface [polypeptide binding]; other site 243233002312 Subunit III/VIa interface; other site 243233002313 Subunit III/Vb interface [polypeptide binding]; other site 243233002314 Transposase domain (DUF772); Region: DUF772; pfam05598 243233002315 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 243233002316 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243233002317 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 243233002318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233002319 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 243233002320 FeS/SAM binding site; other site 243233002321 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 243233002322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243233002323 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243233002324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233002325 Walker A/P-loop; other site 243233002326 ATP binding site [chemical binding]; other site 243233002327 Q-loop/lid; other site 243233002328 ABC transporter signature motif; other site 243233002329 Walker B; other site 243233002330 D-loop; other site 243233002331 H-loop/switch region; other site 243233002332 EAL domain; Region: EAL; pfam00563 243233002333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243233002334 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243233002335 substrate binding pocket [chemical binding]; other site 243233002336 membrane-bound complex binding site; other site 243233002337 hinge residues; other site 243233002338 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 243233002339 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 243233002340 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 243233002341 putative catalytic motif [active] 243233002342 putative substrate binding site [chemical binding]; other site 243233002343 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 243233002344 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 243233002345 NAD(P) binding site [chemical binding]; other site 243233002346 homodimer interface [polypeptide binding]; other site 243233002347 substrate binding site [chemical binding]; other site 243233002348 active site 243233002349 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243233002350 23S rRNA interface [nucleotide binding]; other site 243233002351 L3 interface [polypeptide binding]; other site 243233002352 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243233002353 Transposase; Region: HTH_Tnp_1; cl17663 243233002354 putative transposase OrfB; Reviewed; Region: PHA02517 243233002355 HTH-like domain; Region: HTH_21; pfam13276 243233002356 Integrase core domain; Region: rve; pfam00665 243233002357 Integrase core domain; Region: rve_3; pfam13683 243233002358 Ycf46; Provisional; Region: ycf46; CHL00195 243233002359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233002360 Walker A motif; other site 243233002361 ATP binding site [chemical binding]; other site 243233002362 Walker B motif; other site 243233002363 arginine finger; other site 243233002364 Cupin domain; Region: Cupin_2; pfam07883 243233002365 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 243233002366 active site clefts [active] 243233002367 zinc binding site [ion binding]; other site 243233002368 dimer interface [polypeptide binding]; other site 243233002369 Protein of unknown function (DUF938); Region: DUF938; pfam06080 243233002370 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243233002371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233002372 Walker A motif; other site 243233002373 ATP binding site [chemical binding]; other site 243233002374 Walker B motif; other site 243233002375 arginine finger; other site 243233002376 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233002377 acyl carrier protein; Provisional; Region: PRK09184 243233002378 Predicted membrane protein [Function unknown]; Region: COG4648 243233002379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243233002380 putative acyl-acceptor binding pocket; other site 243233002381 Predicted exporter [General function prediction only]; Region: COG4258 243233002382 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243233002383 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 243233002384 NodB motif; other site 243233002385 active site 243233002386 catalytic site [active] 243233002387 metal binding site [ion binding]; metal-binding site 243233002388 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233002389 Methyltransferase domain; Region: Methyltransf_12; pfam08242 243233002390 S-adenosylmethionine binding site [chemical binding]; other site 243233002391 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 243233002392 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243233002393 dimer interface [polypeptide binding]; other site 243233002394 active site 243233002395 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 243233002396 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 243233002397 putative active site 1 [active] 243233002398 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243233002399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233002400 NAD(P) binding site [chemical binding]; other site 243233002401 active site 243233002402 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243233002403 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243233002404 CRISPR-associated protein (Cas_Cas2CT1978); Region: Cas_Cas2CT1978; pfam09707 243233002405 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 243233002406 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 243233002407 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 243233002408 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 243233002409 CT1975-like protein; Region: Cas_CT1975; pfam09344 243233002410 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 243233002411 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 243233002412 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 243233002413 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 243233002414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233002415 MAEBL; Provisional; Region: PTZ00121 243233002416 Cytochrome c; Region: Cytochrom_C; cl11414 243233002417 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 243233002418 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 243233002419 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 243233002420 active site 243233002421 catalytic site [active] 243233002422 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 243233002423 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 243233002424 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 243233002425 Amidase; Region: Amidase; cl11426 243233002426 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 243233002427 heme exporter protein CcmC; Region: ccmC; TIGR01191 243233002428 CcmB protein; Region: CcmB; pfam03379 243233002429 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 243233002430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233002431 Walker A/P-loop; other site 243233002432 ATP binding site [chemical binding]; other site 243233002433 Q-loop/lid; other site 243233002434 ABC transporter signature motif; other site 243233002435 Walker B; other site 243233002436 D-loop; other site 243233002437 H-loop/switch region; other site 243233002438 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 243233002439 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 243233002440 MgtC family; Region: MgtC; pfam02308 243233002441 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243233002442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233002443 motif II; other site 243233002444 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 243233002445 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243233002446 dimer interface [polypeptide binding]; other site 243233002447 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 243233002448 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 243233002449 active site 243233002450 metal binding site [ion binding]; metal-binding site 243233002451 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 243233002452 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 243233002453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243233002454 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243233002455 Walker A/P-loop; other site 243233002456 ATP binding site [chemical binding]; other site 243233002457 Q-loop/lid; other site 243233002458 ABC transporter signature motif; other site 243233002459 Walker B; other site 243233002460 D-loop; other site 243233002461 H-loop/switch region; other site 243233002462 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243233002463 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243233002464 CoA-ligase; Region: Ligase_CoA; pfam00549 243233002465 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243233002466 CoA binding domain; Region: CoA_binding; pfam02629 243233002467 CoA-ligase; Region: Ligase_CoA; pfam00549 243233002468 NAD synthetase; Provisional; Region: PRK13981 243233002469 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 243233002470 multimer interface [polypeptide binding]; other site 243233002471 active site 243233002472 catalytic triad [active] 243233002473 protein interface 1 [polypeptide binding]; other site 243233002474 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243233002475 homodimer interface [polypeptide binding]; other site 243233002476 NAD binding pocket [chemical binding]; other site 243233002477 ATP binding pocket [chemical binding]; other site 243233002478 Mg binding site [ion binding]; other site 243233002479 active-site loop [active] 243233002480 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 243233002481 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 243233002482 substrate binding site [chemical binding]; other site 243233002483 ATP binding site [chemical binding]; other site 243233002484 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243233002485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233002486 binding surface 243233002487 TPR motif; other site 243233002488 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 243233002489 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243233002490 RNA binding surface [nucleotide binding]; other site 243233002491 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243233002492 active site 243233002493 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 243233002494 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 243233002495 ZIP Zinc transporter; Region: Zip; pfam02535 243233002496 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 243233002497 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 243233002498 potassium uptake protein; Region: kup; TIGR00794 243233002499 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 243233002500 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243233002501 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233002502 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233002503 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233002504 Transposase domain (DUF772); Region: DUF772; pfam05598 243233002505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233002506 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233002507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233002508 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243233002509 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243233002510 putative dimer interface [polypeptide binding]; other site 243233002511 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 243233002512 PAS domain S-box; Region: sensory_box; TIGR00229 243233002513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233002514 PAS domain; Region: PAS_9; pfam13426 243233002515 putative active site [active] 243233002516 heme pocket [chemical binding]; other site 243233002517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233002518 PAS domain; Region: PAS_9; pfam13426 243233002519 putative active site [active] 243233002520 heme pocket [chemical binding]; other site 243233002521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233002522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233002523 metal binding site [ion binding]; metal-binding site 243233002524 active site 243233002525 I-site; other site 243233002526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233002527 PAS domain S-box; Region: sensory_box; TIGR00229 243233002528 PAS domain; Region: PAS_8; pfam13188 243233002529 PAS domain S-box; Region: sensory_box; TIGR00229 243233002530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233002531 putative active site [active] 243233002532 heme pocket [chemical binding]; other site 243233002533 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243233002534 GAF domain; Region: GAF; pfam01590 243233002535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233002536 PAS domain; Region: PAS_9; pfam13426 243233002537 putative active site [active] 243233002538 heme pocket [chemical binding]; other site 243233002539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233002540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233002541 metal binding site [ion binding]; metal-binding site 243233002542 active site 243233002543 I-site; other site 243233002544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233002545 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 243233002546 [2Fe-2S] cluster binding site [ion binding]; other site 243233002547 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243233002548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243233002549 active site 243233002550 trimerization site [polypeptide binding]; other site 243233002551 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243233002552 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243233002553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233002554 catalytic residue [active] 243233002555 FeS assembly protein SufD; Region: sufD; TIGR01981 243233002556 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 243233002557 FeS assembly ATPase SufC; Region: sufC; TIGR01978 243233002558 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 243233002559 Walker A/P-loop; other site 243233002560 ATP binding site [chemical binding]; other site 243233002561 Q-loop/lid; other site 243233002562 ABC transporter signature motif; other site 243233002563 Walker B; other site 243233002564 D-loop; other site 243233002565 H-loop/switch region; other site 243233002566 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 243233002567 putative ABC transporter; Region: ycf24; CHL00085 243233002568 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 243233002569 Transcriptional regulator; Region: Rrf2; pfam02082 243233002570 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 243233002571 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 243233002572 dimer interface [polypeptide binding]; other site 243233002573 PYR/PP interface [polypeptide binding]; other site 243233002574 TPP binding site [chemical binding]; other site 243233002575 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243233002576 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 243233002577 TPP-binding site [chemical binding]; other site 243233002578 dimer interface [polypeptide binding]; other site 243233002579 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 243233002580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233002581 S-adenosylmethionine binding site [chemical binding]; other site 243233002582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243233002583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233002584 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 243233002585 putative dimerization interface [polypeptide binding]; other site 243233002586 Ceramidase; Region: Ceramidase; pfam05875 243233002587 Cupin domain; Region: Cupin_2; cl17218 243233002588 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 243233002589 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 243233002590 C-terminal domain interface [polypeptide binding]; other site 243233002591 GSH binding site (G-site) [chemical binding]; other site 243233002592 dimer interface [polypeptide binding]; other site 243233002593 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 243233002594 putative N-terminal domain interface [polypeptide binding]; other site 243233002595 putative dimer interface [polypeptide binding]; other site 243233002596 putative substrate binding pocket (H-site) [chemical binding]; other site 243233002597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 243233002598 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243233002599 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 243233002600 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233002601 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243233002602 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243233002603 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233002604 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243233002605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233002606 motif II; other site 243233002607 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243233002608 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243233002609 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 243233002610 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 243233002611 AMP-binding enzyme; Region: AMP-binding; pfam00501 243233002612 acyl-activating enzyme (AAE) consensus motif; other site 243233002613 putative AMP binding site [chemical binding]; other site 243233002614 putative active site [active] 243233002615 putative CoA binding site [chemical binding]; other site 243233002616 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243233002617 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243233002618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243233002619 putative acyl-acceptor binding pocket; other site 243233002620 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 243233002621 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 243233002622 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 243233002623 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 243233002624 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243233002625 ATP binding site [chemical binding]; other site 243233002626 Mg++ binding site [ion binding]; other site 243233002627 motif III; other site 243233002628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233002629 nucleotide binding region [chemical binding]; other site 243233002630 ATP-binding site [chemical binding]; other site 243233002631 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 243233002632 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 243233002633 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 243233002634 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243233002635 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 243233002636 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243233002637 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 243233002638 iron-sulfur cluster [ion binding]; other site 243233002639 [2Fe-2S] cluster binding site [ion binding]; other site 243233002640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243233002641 hydrophobic ligand binding site; other site 243233002642 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243233002643 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 243233002644 putative NADP binding site [chemical binding]; other site 243233002645 putative substrate binding site [chemical binding]; other site 243233002646 active site 243233002647 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 243233002648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243233002649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233002650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243233002651 Dynamin family; Region: Dynamin_N; pfam00350 243233002652 G1 box; other site 243233002653 GTP/Mg2+ binding site [chemical binding]; other site 243233002654 G2 box; other site 243233002655 Switch I region; other site 243233002656 G3 box; other site 243233002657 Switch II region; other site 243233002658 G4 box; other site 243233002659 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 243233002660 active site 243233002661 metal binding site [ion binding]; metal-binding site 243233002662 homotetramer interface [polypeptide binding]; other site 243233002663 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 243233002664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233002665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233002666 homodimer interface [polypeptide binding]; other site 243233002667 catalytic residue [active] 243233002668 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 243233002669 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243233002670 dimer interface [polypeptide binding]; other site 243233002671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233002672 catalytic residue [active] 243233002673 peroxidase; Provisional; Region: PRK15000 243233002674 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243233002675 dimer interface [polypeptide binding]; other site 243233002676 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243233002677 catalytic triad [active] 243233002678 peroxidatic and resolving cysteines [active] 243233002679 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 243233002680 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 243233002681 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 243233002682 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 243233002683 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 243233002684 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 243233002685 active site 243233002686 substrate binding site [chemical binding]; other site 243233002687 Mg2+ binding site [ion binding]; other site 243233002688 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 243233002689 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 243233002690 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 243233002691 NAD(P) binding site [chemical binding]; other site 243233002692 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243233002693 30S subunit binding site; other site 243233002694 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 243233002695 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 243233002696 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 243233002697 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 243233002698 RNA binding site [nucleotide binding]; other site 243233002699 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 243233002700 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243233002701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233002702 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 243233002703 Part of AAA domain; Region: AAA_19; pfam13245 243233002704 Family description; Region: UvrD_C_2; pfam13538 243233002705 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243233002706 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 243233002707 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 243233002708 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 243233002709 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 243233002710 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 243233002711 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 243233002712 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 243233002713 DsbD alpha interface [polypeptide binding]; other site 243233002714 catalytic residues [active] 243233002715 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243233002716 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233002717 catalytic residues [active] 243233002718 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243233002719 Dehydroquinase class II; Region: DHquinase_II; pfam01220 243233002720 active site 243233002721 trimer interface [polypeptide binding]; other site 243233002722 dimer interface [polypeptide binding]; other site 243233002723 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 243233002724 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243233002725 carboxyltransferase (CT) interaction site; other site 243233002726 biotinylation site [posttranslational modification]; other site 243233002727 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243233002728 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243233002729 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243233002730 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243233002731 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 243233002732 Methyltransferase domain; Region: Methyltransf_18; pfam12847 243233002733 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 243233002734 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 243233002735 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243233002736 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243233002737 putative RNA binding site [nucleotide binding]; other site 243233002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233002739 S-adenosylmethionine binding site [chemical binding]; other site 243233002740 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 243233002741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233002742 S-adenosylmethionine binding site [chemical binding]; other site 243233002743 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243233002744 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243233002745 RF-1 domain; Region: RF-1; pfam00472 243233002746 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 243233002747 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243233002748 tRNA; other site 243233002749 putative tRNA binding site [nucleotide binding]; other site 243233002750 putative NADP binding site [chemical binding]; other site 243233002751 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 243233002752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233002753 TPR motif; other site 243233002754 binding surface 243233002755 TPR repeat; Region: TPR_11; pfam13414 243233002756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233002757 binding surface 243233002758 TPR motif; other site 243233002759 TPR repeat; Region: TPR_11; pfam13414 243233002760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233002761 binding surface 243233002762 TPR motif; other site 243233002763 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 243233002764 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 243233002765 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 243233002766 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 243233002767 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243233002768 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 243233002769 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243233002770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233002771 active site 243233002772 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 243233002773 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243233002774 5S rRNA interface [nucleotide binding]; other site 243233002775 CTC domain interface [polypeptide binding]; other site 243233002776 L16 interface [polypeptide binding]; other site 243233002777 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243233002778 putative active site [active] 243233002779 catalytic residue [active] 243233002780 elongation factor Tu; Reviewed; Region: PRK00049 243233002781 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243233002782 G1 box; other site 243233002783 GEF interaction site [polypeptide binding]; other site 243233002784 GTP/Mg2+ binding site [chemical binding]; other site 243233002785 Switch I region; other site 243233002786 G2 box; other site 243233002787 G3 box; other site 243233002788 Switch II region; other site 243233002789 G4 box; other site 243233002790 G5 box; other site 243233002791 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243233002792 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243233002793 Antibiotic Binding Site [chemical binding]; other site 243233002794 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 243233002795 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243233002796 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243233002797 putative homodimer interface [polypeptide binding]; other site 243233002798 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243233002799 heterodimer interface [polypeptide binding]; other site 243233002800 homodimer interface [polypeptide binding]; other site 243233002801 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243233002802 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243233002803 23S rRNA interface [nucleotide binding]; other site 243233002804 L7/L12 interface [polypeptide binding]; other site 243233002805 putative thiostrepton binding site; other site 243233002806 L25 interface [polypeptide binding]; other site 243233002807 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243233002808 mRNA/rRNA interface [nucleotide binding]; other site 243233002809 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243233002810 23S rRNA interface [nucleotide binding]; other site 243233002811 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243233002812 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243233002813 peripheral dimer interface [polypeptide binding]; other site 243233002814 core dimer interface [polypeptide binding]; other site 243233002815 L10 interface [polypeptide binding]; other site 243233002816 L11 interface [polypeptide binding]; other site 243233002817 putative EF-Tu interaction site [polypeptide binding]; other site 243233002818 putative EF-G interaction site [polypeptide binding]; other site 243233002819 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243233002820 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 243233002821 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 243233002822 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 243233002823 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243233002824 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 243233002825 RPB12 interaction site [polypeptide binding]; other site 243233002826 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243233002827 RPB3 interaction site [polypeptide binding]; other site 243233002828 RPB1 interaction site [polypeptide binding]; other site 243233002829 RPB11 interaction site [polypeptide binding]; other site 243233002830 RPB10 interaction site [polypeptide binding]; other site 243233002831 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 243233002832 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 243233002833 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 243233002834 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 243233002835 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 243233002836 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 243233002837 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 243233002838 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 243233002839 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243233002840 DNA binding site [nucleotide binding] 243233002841 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243233002842 Cytochrome c553 [Energy production and conversion]; Region: COG2863 243233002843 Cytochrome c; Region: Cytochrom_C; cl11414 243233002844 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 243233002845 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 243233002846 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 243233002847 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 243233002848 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 243233002849 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 243233002850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233002851 dimer interface [polypeptide binding]; other site 243233002852 conserved gate region; other site 243233002853 putative PBP binding loops; other site 243233002854 ABC-ATPase subunit interface; other site 243233002855 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 243233002856 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 243233002857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233002858 dimer interface [polypeptide binding]; other site 243233002859 conserved gate region; other site 243233002860 putative PBP binding loops; other site 243233002861 ABC-ATPase subunit interface; other site 243233002862 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 243233002863 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243233002864 Walker A/P-loop; other site 243233002865 ATP binding site [chemical binding]; other site 243233002866 Q-loop/lid; other site 243233002867 ABC transporter signature motif; other site 243233002868 Walker B; other site 243233002869 D-loop; other site 243233002870 H-loop/switch region; other site 243233002871 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243233002872 PhoU domain; Region: PhoU; pfam01895 243233002873 PhoU domain; Region: PhoU; pfam01895 243233002874 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 243233002875 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243233002876 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 243233002877 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243233002878 thiS-thiF/thiG interaction site; other site 243233002879 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243233002880 ThiS interaction site; other site 243233002881 putative active site [active] 243233002882 tetramer interface [polypeptide binding]; other site 243233002883 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 243233002884 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 243233002885 active site 243233002886 zinc binding site [ion binding]; other site 243233002887 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 243233002888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243233002889 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 243233002890 EcsC protein family; Region: EcsC; pfam12787 243233002891 Transposase domain (DUF772); Region: DUF772; pfam05598 243233002892 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233002893 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233002894 competence damage-inducible protein A; Provisional; Region: PRK00549 243233002895 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243233002896 putative MPT binding site; other site 243233002897 Competence-damaged protein; Region: CinA; cl00666 243233002898 Predicted permeases [General function prediction only]; Region: COG0679 243233002899 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243233002900 active site 243233002901 dimer interface [polypeptide binding]; other site 243233002902 Family description; Region: DsbD_2; pfam13386 243233002903 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243233002904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233002905 Walker A motif; other site 243233002906 ATP binding site [chemical binding]; other site 243233002907 Walker B motif; other site 243233002908 arginine finger; other site 243233002909 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233002910 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 243233002911 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 243233002912 G1 box; other site 243233002913 GTP/Mg2+ binding site [chemical binding]; other site 243233002914 Switch I region; other site 243233002915 G2 box; other site 243233002916 G3 box; other site 243233002917 Switch II region; other site 243233002918 G4 box; other site 243233002919 G5 box; other site 243233002920 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 243233002921 Nucleoside recognition; Region: Gate; pfam07670 243233002922 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 243233002923 Nucleoside recognition; Region: Gate; pfam07670 243233002924 FeoA domain; Region: FeoA; pfam04023 243233002925 argininosuccinate synthase; Provisional; Region: PRK13820 243233002926 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 243233002927 ANP binding site [chemical binding]; other site 243233002928 Substrate Binding Site II [chemical binding]; other site 243233002929 Substrate Binding Site I [chemical binding]; other site 243233002930 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 243233002931 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243233002932 Multicopper oxidase; Region: Cu-oxidase; pfam00394 243233002933 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243233002934 PAS fold; Region: PAS; pfam00989 243233002935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233002936 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243233002937 Walker A motif; other site 243233002938 ATP binding site [chemical binding]; other site 243233002939 Walker B motif; other site 243233002940 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233002941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243233002942 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243233002943 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 243233002944 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 243233002945 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 243233002946 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243233002947 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 243233002948 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 243233002949 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 243233002950 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 243233002951 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 243233002952 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243233002953 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 243233002954 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 243233002955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233002956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233002957 homodimer interface [polypeptide binding]; other site 243233002958 catalytic residue [active] 243233002959 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243233002960 type II secretion system protein E; Region: type_II_gspE; TIGR02533 243233002961 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243233002962 Walker A motif; other site 243233002963 ATP binding site [chemical binding]; other site 243233002964 Walker B motif; other site 243233002965 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243233002966 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243233002967 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 243233002968 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243233002969 Type II transport protein GspH; Region: GspH; pfam12019 243233002970 general secretion pathway protein J; Validated; Region: PRK08808 243233002971 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 243233002972 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243233002973 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 243233002974 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 243233002975 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243233002976 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243233002977 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243233002978 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 243233002979 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243233002980 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 243233002981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233002982 active site 243233002983 biotin synthase; Region: bioB; TIGR00433 243233002984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233002985 FeS/SAM binding site; other site 243233002986 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 243233002987 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 243233002988 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 243233002989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233002990 catalytic residue [active] 243233002991 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 243233002992 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 243233002993 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 243233002994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233002995 S-adenosylmethionine binding site [chemical binding]; other site 243233002996 AAA domain; Region: AAA_26; pfam13500 243233002997 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243233002998 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 243233002999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243233003000 Beta-Casp domain; Region: Beta-Casp; smart01027 243233003001 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243233003002 Uncharacterized conserved protein [Function unknown]; Region: COG0327 243233003003 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 243233003004 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 243233003005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243233003006 acyl-activating enzyme (AAE) consensus motif; other site 243233003007 CoA binding site [chemical binding]; other site 243233003008 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 243233003009 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 243233003010 putative catalytic motif [active] 243233003011 substrate binding site [chemical binding]; other site 243233003012 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 243233003013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233003014 active site 243233003015 motif I; other site 243233003016 motif II; other site 243233003017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233003018 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 243233003019 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 243233003020 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 243233003021 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243233003022 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 243233003023 hydrogenase 4 subunit F; Validated; Region: PRK06458 243233003024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233003025 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 243233003026 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 243233003027 hydrogenase 4 subunit B; Validated; Region: PRK06521 243233003028 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233003029 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243233003030 putative active site [active] 243233003031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243233003032 putative DNA binding site [nucleotide binding]; other site 243233003033 putative Zn2+ binding site [ion binding]; other site 243233003034 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243233003035 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243233003036 NADP-binding site; other site 243233003037 homotetramer interface [polypeptide binding]; other site 243233003038 substrate binding site [chemical binding]; other site 243233003039 homodimer interface [polypeptide binding]; other site 243233003040 active site 243233003041 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 243233003042 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 243233003043 NADP binding site [chemical binding]; other site 243233003044 active site 243233003045 putative substrate binding site [chemical binding]; other site 243233003046 Uncharacterized conserved protein [Function unknown]; Region: COG5464 243233003047 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 243233003048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 243233003049 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243233003050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233003051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233003052 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243233003053 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243233003054 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 243233003055 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233003056 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 243233003057 metal-binding site 243233003058 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243233003059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233003060 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 243233003061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233003062 putative ADP-binding pocket [chemical binding]; other site 243233003063 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 243233003064 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 243233003065 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 243233003066 Methyltransferase domain; Region: Methyltransf_11; pfam08241 243233003067 S-adenosylmethionine binding site [chemical binding]; other site 243233003068 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243233003069 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 243233003070 NAD binding site [chemical binding]; other site 243233003071 putative substrate binding site 2 [chemical binding]; other site 243233003072 putative substrate binding site 1 [chemical binding]; other site 243233003073 active site 243233003074 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 243233003075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233003076 putative metal binding site; other site 243233003077 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 243233003078 putative glycosyl transferase; Provisional; Region: PRK10307 243233003079 O-Antigen ligase; Region: Wzy_C; pfam04932 243233003080 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 243233003081 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243233003082 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 243233003083 SLBB domain; Region: SLBB; pfam10531 243233003084 Chain length determinant protein; Region: Wzz; pfam02706 243233003085 Transposase domain (DUF772); Region: DUF772; pfam05598 243233003086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233003087 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233003088 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243233003089 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243233003090 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 243233003091 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 243233003092 Nucleotide binding site [chemical binding]; other site 243233003093 P loop; other site 243233003094 DTAP/Switch II; other site 243233003095 Switch I; other site 243233003096 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 243233003097 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 243233003098 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 243233003099 Walker A/P-loop; other site 243233003100 ATP binding site [chemical binding]; other site 243233003101 Q-loop/lid; other site 243233003102 ABC transporter signature motif; other site 243233003103 Walker B; other site 243233003104 D-loop; other site 243233003105 H-loop/switch region; other site 243233003106 TOBE-like domain; Region: TOBE_3; pfam12857 243233003107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233003108 dimer interface [polypeptide binding]; other site 243233003109 conserved gate region; other site 243233003110 putative PBP binding loops; other site 243233003111 ABC-ATPase subunit interface; other site 243233003112 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243233003113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233003114 dimer interface [polypeptide binding]; other site 243233003115 conserved gate region; other site 243233003116 putative PBP binding loops; other site 243233003117 ABC-ATPase subunit interface; other site 243233003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 243233003119 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 243233003120 Cytochrome c; Region: Cytochrom_C; cl11414 243233003121 Cytochrome c; Region: Cytochrom_C; cl11414 243233003122 Cytochrome c; Region: Cytochrom_C; pfam00034 243233003123 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 243233003124 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 243233003125 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 243233003126 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243233003127 dinuclear metal binding motif [ion binding]; other site 243233003128 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243233003129 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 243233003130 Cu(I) binding site [ion binding]; other site 243233003131 Protein of unknown function (DUF461); Region: DUF461; pfam04314 243233003132 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 243233003133 Dynamin family; Region: Dynamin_N; pfam00350 243233003134 G1 box; other site 243233003135 GTP/Mg2+ binding site [chemical binding]; other site 243233003136 G2 box; other site 243233003137 Switch I region; other site 243233003138 G3 box; other site 243233003139 Switch II region; other site 243233003140 G4 box; other site 243233003141 G5 box; other site 243233003142 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 243233003143 dimerization interface [polypeptide binding]; other site 243233003144 putative path to active site cavity [active] 243233003145 diiron center [ion binding]; other site 243233003146 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 243233003147 dimerization interface [polypeptide binding]; other site 243233003148 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 243233003149 Transposase domain (DUF772); Region: DUF772; pfam05598 243233003150 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233003151 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233003152 Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964 243233003153 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233003154 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 243233003155 catalytic loop [active] 243233003156 iron binding site [ion binding]; other site 243233003157 Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210 243233003158 FAD binding pocket [chemical binding]; other site 243233003159 FAD binding motif [chemical binding]; other site 243233003160 phosphate binding motif [ion binding]; other site 243233003161 beta-alpha-beta structure motif; other site 243233003162 NAD binding pocket [chemical binding]; other site 243233003163 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243233003164 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243233003165 ring oligomerisation interface [polypeptide binding]; other site 243233003166 ATP/Mg binding site [chemical binding]; other site 243233003167 stacking interactions; other site 243233003168 hinge regions; other site 243233003169 HDOD domain; Region: HDOD; pfam08668 243233003170 Response regulator receiver domain; Region: Response_reg; pfam00072 243233003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233003172 active site 243233003173 phosphorylation site [posttranslational modification] 243233003174 intermolecular recognition site; other site 243233003175 dimerization interface [polypeptide binding]; other site 243233003176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233003177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233003178 metal binding site [ion binding]; metal-binding site 243233003179 active site 243233003180 I-site; other site 243233003181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233003182 PAS domain; Region: PAS_9; pfam13426 243233003183 putative active site [active] 243233003184 heme pocket [chemical binding]; other site 243233003185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233003186 PAS domain; Region: PAS_9; pfam13426 243233003187 putative active site [active] 243233003188 heme pocket [chemical binding]; other site 243233003189 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243233003190 GAF domain; Region: GAF; pfam01590 243233003191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233003192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233003193 dimer interface [polypeptide binding]; other site 243233003194 phosphorylation site [posttranslational modification] 243233003195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233003196 ATP binding site [chemical binding]; other site 243233003197 Mg2+ binding site [ion binding]; other site 243233003198 G-X-G motif; other site 243233003199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243233003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233003201 active site 243233003202 phosphorylation site [posttranslational modification] 243233003203 intermolecular recognition site; other site 243233003204 dimerization interface [polypeptide binding]; other site 243233003205 Response regulator receiver domain; Region: Response_reg; pfam00072 243233003206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233003207 active site 243233003208 phosphorylation site [posttranslational modification] 243233003209 intermolecular recognition site; other site 243233003210 dimerization interface [polypeptide binding]; other site 243233003211 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 243233003212 putative binding surface; other site 243233003213 active site 243233003214 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243233003215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233003216 Walker A motif; other site 243233003217 ATP binding site [chemical binding]; other site 243233003218 Walker B motif; other site 243233003219 arginine finger; other site 243233003220 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233003221 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 243233003222 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243233003223 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 243233003224 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 243233003225 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 243233003226 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 243233003227 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 243233003228 [4Fe-4S] binding site [ion binding]; other site 243233003229 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243233003230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243233003231 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 243233003232 molybdopterin cofactor binding site; other site 243233003233 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 243233003234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233003235 S-adenosylmethionine binding site [chemical binding]; other site 243233003236 RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399 243233003237 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 243233003238 putative active site [active] 243233003239 adenylation catalytic residue [active] 243233003240 hypothetical protein; Provisional; Region: PRK08609 243233003241 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 243233003242 active site 243233003243 primer binding site [nucleotide binding]; other site 243233003244 NTP binding site [chemical binding]; other site 243233003245 metal binding triad [ion binding]; metal-binding site 243233003246 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 243233003247 active site 243233003248 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243233003249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243233003250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233003251 Walker A/P-loop; other site 243233003252 ATP binding site [chemical binding]; other site 243233003253 Q-loop/lid; other site 243233003254 ABC transporter signature motif; other site 243233003255 Walker B; other site 243233003256 D-loop; other site 243233003257 H-loop/switch region; other site 243233003258 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 243233003259 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 243233003260 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 243233003261 Zn binding site [ion binding]; other site 243233003262 Transposase, Mutator family; Region: Transposase_mut; pfam00872 243233003263 MULE transposase domain; Region: MULE; pfam10551 243233003264 hypothetical protein; Validated; Region: PRK00110 243233003265 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 243233003266 active site 243233003267 putative DNA-binding cleft [nucleotide binding]; other site 243233003268 dimer interface [polypeptide binding]; other site 243233003269 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243233003270 RuvA N terminal domain; Region: RuvA_N; pfam01330 243233003271 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 243233003272 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243233003273 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243233003274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233003275 Walker A motif; other site 243233003276 Walker A motif; other site 243233003277 ATP binding site [chemical binding]; other site 243233003278 Walker B motif; other site 243233003279 arginine finger; other site 243233003280 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243233003281 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243233003282 active site 243233003283 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243233003284 G1 box; other site 243233003285 GTP/Mg2+ binding site [chemical binding]; other site 243233003286 G2 box; other site 243233003287 Switch I region; other site 243233003288 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243233003289 Switch II region; other site 243233003290 G4 box; other site 243233003291 G5 box; other site 243233003292 TolQ protein; Region: tolQ; TIGR02796 243233003293 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233003294 TolR protein; Region: tolR; TIGR02801 243233003295 TolA protein; Region: tolA_full; TIGR02794 243233003296 TonB C terminal; Region: TonB_2; pfam13103 243233003297 translocation protein TolB; Provisional; Region: tolB; PRK04922 243233003298 TolB amino-terminal domain; Region: TolB_N; pfam04052 243233003299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243233003300 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243233003301 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243233003302 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243233003303 ligand binding site [chemical binding]; other site 243233003304 SlyX; Region: SlyX; cl01090 243233003305 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243233003306 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243233003307 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 243233003308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233003309 FeS/SAM binding site; other site 243233003310 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 243233003311 Ligand Binding Site [chemical binding]; other site 243233003312 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243233003313 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243233003314 HIGH motif; other site 243233003315 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243233003316 active site 243233003317 KMSKS motif; other site 243233003318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233003319 PAS domain; Region: PAS_9; pfam13426 243233003320 putative active site [active] 243233003321 heme pocket [chemical binding]; other site 243233003322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233003323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233003324 metal binding site [ion binding]; metal-binding site 243233003325 active site 243233003326 I-site; other site 243233003327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233003328 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 243233003329 active site 243233003330 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243233003331 Acyl transferase domain; Region: Acyl_transf_1; cl08282 243233003332 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243233003333 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243233003334 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 243233003335 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 243233003336 putative NADP binding site [chemical binding]; other site 243233003337 active site 243233003338 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 243233003339 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 243233003340 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233003341 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 243233003342 Flavoprotein; Region: Flavoprotein; pfam02441 243233003343 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 243233003344 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 243233003345 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 243233003346 quinone interaction residues [chemical binding]; other site 243233003347 active site 243233003348 catalytic residues [active] 243233003349 FMN binding site [chemical binding]; other site 243233003350 substrate binding site [chemical binding]; other site 243233003351 hypothetical protein; Provisional; Region: PRK02227 243233003352 Protein of unknown function (DUF447); Region: DUF447; pfam04289 243233003353 dihydropteroate synthase-related protein; Region: TIGR00284 243233003354 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 243233003355 substrate binding pocket [chemical binding]; other site 243233003356 dimer interface [polypeptide binding]; other site 243233003357 inhibitor binding site; inhibition site 243233003358 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 243233003359 CheB methylesterase; Region: CheB_methylest; pfam01339 243233003360 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243233003361 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243233003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233003363 S-adenosylmethionine binding site [chemical binding]; other site 243233003364 PAS domain; Region: PAS_10; pfam13596 243233003365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233003366 PAS domain; Region: PAS_9; pfam13426 243233003367 putative active site [active] 243233003368 heme pocket [chemical binding]; other site 243233003369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233003370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233003371 metal binding site [ion binding]; metal-binding site 243233003372 active site 243233003373 I-site; other site 243233003374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233003375 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 243233003376 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243233003377 active site 243233003378 dimer interface [polypeptide binding]; other site 243233003379 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243233003380 dimer interface [polypeptide binding]; other site 243233003381 active site 243233003382 argininosuccinate lyase; Provisional; Region: PRK00855 243233003383 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243233003384 active sites [active] 243233003385 tetramer interface [polypeptide binding]; other site 243233003386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243233003387 catalytic core [active] 243233003388 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243233003389 Domain of unknown function DUF21; Region: DUF21; pfam01595 243233003390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243233003391 Transporter associated domain; Region: CorC_HlyC; smart01091 243233003392 6-phosphofructokinase; Provisional; Region: PRK14072 243233003393 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 243233003394 active site 243233003395 ADP/pyrophosphate binding site [chemical binding]; other site 243233003396 dimerization interface [polypeptide binding]; other site 243233003397 allosteric effector site; other site 243233003398 fructose-1,6-bisphosphate binding site; other site 243233003399 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 243233003400 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 243233003401 oligopeptidase A; Provisional; Region: PRK10911 243233003402 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 243233003403 active site 243233003404 Zn binding site [ion binding]; other site 243233003405 Rubredoxin [Energy production and conversion]; Region: COG1773 243233003406 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243233003407 iron binding site [ion binding]; other site 243233003408 Tim44-like domain; Region: Tim44; pfam04280 243233003409 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243233003410 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233003411 catalytic residues [active] 243233003412 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 243233003413 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 243233003414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243233003415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243233003416 DNA binding residues [nucleotide binding] 243233003417 dimerization interface [polypeptide binding]; other site 243233003418 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 243233003419 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243233003420 NAD binding site [chemical binding]; other site 243233003421 homotetramer interface [polypeptide binding]; other site 243233003422 homodimer interface [polypeptide binding]; other site 243233003423 substrate binding site [chemical binding]; other site 243233003424 active site 243233003425 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 243233003426 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 243233003427 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243233003428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233003429 dimer interface [polypeptide binding]; other site 243233003430 conserved gate region; other site 243233003431 putative PBP binding loops; other site 243233003432 ABC-ATPase subunit interface; other site 243233003433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 243233003434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233003435 dimer interface [polypeptide binding]; other site 243233003436 conserved gate region; other site 243233003437 putative PBP binding loops; other site 243233003438 ABC-ATPase subunit interface; other site 243233003439 phosphoserine phosphatase SerB; Region: serB; TIGR00338 243233003440 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243233003441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233003442 motif II; other site 243233003443 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243233003444 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243233003445 Walker A/P-loop; other site 243233003446 ATP binding site [chemical binding]; other site 243233003447 Q-loop/lid; other site 243233003448 ABC transporter signature motif; other site 243233003449 Walker B; other site 243233003450 D-loop; other site 243233003451 H-loop/switch region; other site 243233003452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243233003453 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243233003454 Walker A/P-loop; other site 243233003455 ATP binding site [chemical binding]; other site 243233003456 Q-loop/lid; other site 243233003457 ABC transporter signature motif; other site 243233003458 Walker B; other site 243233003459 D-loop; other site 243233003460 H-loop/switch region; other site 243233003461 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 243233003462 Uncharacterized conserved protein [Function unknown]; Region: COG3339 243233003463 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 243233003464 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 243233003465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233003466 NAD(P) binding site [chemical binding]; other site 243233003467 active site 243233003468 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 243233003469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233003470 S-adenosylmethionine binding site [chemical binding]; other site 243233003471 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 243233003472 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 243233003473 active site 243233003474 putative substrate binding pocket [chemical binding]; other site 243233003475 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243233003476 glutamate racemase; Provisional; Region: PRK00865 243233003477 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 243233003478 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 243233003479 ligand binding site [chemical binding]; other site 243233003480 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 243233003481 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233003482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233003483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233003484 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 243233003485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233003486 Walker A/P-loop; other site 243233003487 ATP binding site [chemical binding]; other site 243233003488 Q-loop/lid; other site 243233003489 ABC transporter signature motif; other site 243233003490 Walker B; other site 243233003491 D-loop; other site 243233003492 H-loop/switch region; other site 243233003493 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243233003494 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243233003495 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243233003496 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243233003497 NAD binding site [chemical binding]; other site 243233003498 substrate binding site [chemical binding]; other site 243233003499 homodimer interface [polypeptide binding]; other site 243233003500 active site 243233003501 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 243233003502 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 243233003503 substrate binding site; other site 243233003504 tetramer interface; other site 243233003505 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 243233003506 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243233003507 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 243233003508 NADP binding site [chemical binding]; other site 243233003509 active site 243233003510 putative substrate binding site [chemical binding]; other site 243233003511 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 243233003512 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243233003513 putative active site [active] 243233003514 putative PHP Thumb interface [polypeptide binding]; other site 243233003515 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243233003516 generic binding surface II; other site 243233003517 generic binding surface I; other site 243233003518 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243233003519 amidase catalytic site [active] 243233003520 Zn binding residues [ion binding]; other site 243233003521 substrate binding site [chemical binding]; other site 243233003522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243233003523 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 243233003524 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 243233003525 B1 nucleotide binding pocket [chemical binding]; other site 243233003526 B2 nucleotide binding pocket [chemical binding]; other site 243233003527 CAS motifs; other site 243233003528 active site 243233003529 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243233003530 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 243233003531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233003532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233003533 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243233003534 active site 243233003535 metal binding site [ion binding]; metal-binding site 243233003536 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243233003537 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233003538 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233003539 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243233003540 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243233003541 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 243233003542 Uncharacterized conserved protein [Function unknown]; Region: COG0062 243233003543 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243233003544 putative substrate binding site [chemical binding]; other site 243233003545 putative ATP binding site [chemical binding]; other site 243233003546 epoxyqueuosine reductase; Region: TIGR00276 243233003547 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 243233003548 4Fe-4S binding domain; Region: Fer4; cl02805 243233003549 glutathionine S-transferase; Provisional; Region: PRK10542 243233003550 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 243233003551 C-terminal domain interface [polypeptide binding]; other site 243233003552 GSH binding site (G-site) [chemical binding]; other site 243233003553 dimer interface [polypeptide binding]; other site 243233003554 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 243233003555 dimer interface [polypeptide binding]; other site 243233003556 substrate binding pocket (H-site) [chemical binding]; other site 243233003557 N-terminal domain interface [polypeptide binding]; other site 243233003558 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 243233003559 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 243233003560 nucleotide binding site [chemical binding]; other site 243233003561 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243233003562 SBD interface [polypeptide binding]; other site 243233003563 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 243233003564 nucleotide binding site [chemical binding]; other site 243233003565 putative NEF/HSP70 interaction site [polypeptide binding]; other site 243233003566 SBD interface [polypeptide binding]; other site 243233003567 DNA-K related protein; Region: DUF3731; pfam12531 243233003568 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243233003569 nucleoside/Zn binding site; other site 243233003570 dimer interface [polypeptide binding]; other site 243233003571 catalytic motif [active] 243233003572 YccA-like proteins; Region: YccA_like; cd10433 243233003573 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 243233003574 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 243233003575 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 243233003576 RNase E interface [polypeptide binding]; other site 243233003577 trimer interface [polypeptide binding]; other site 243233003578 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243233003579 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243233003580 RNase E interface [polypeptide binding]; other site 243233003581 trimer interface [polypeptide binding]; other site 243233003582 active site 243233003583 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243233003584 putative nucleic acid binding region [nucleotide binding]; other site 243233003585 G-X-X-G motif; other site 243233003586 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243233003587 RNA binding site [nucleotide binding]; other site 243233003588 domain interface; other site 243233003589 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243233003590 16S/18S rRNA binding site [nucleotide binding]; other site 243233003591 S13e-L30e interaction site [polypeptide binding]; other site 243233003592 25S rRNA binding site [nucleotide binding]; other site 243233003593 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243233003594 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 243233003595 Transposase domain (DUF772); Region: DUF772; pfam05598 243233003596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233003597 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233003598 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243233003599 RNA binding site [nucleotide binding]; other site 243233003600 active site 243233003601 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 243233003602 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 243233003603 translation initiation factor IF-2; Region: IF-2; TIGR00487 243233003604 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243233003605 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243233003606 G1 box; other site 243233003607 putative GEF interaction site [polypeptide binding]; other site 243233003608 GTP/Mg2+ binding site [chemical binding]; other site 243233003609 Switch I region; other site 243233003610 G2 box; other site 243233003611 G3 box; other site 243233003612 Switch II region; other site 243233003613 G4 box; other site 243233003614 G5 box; other site 243233003615 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243233003616 Translation-initiation factor 2; Region: IF-2; pfam11987 243233003617 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243233003618 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 243233003619 NusA N-terminal domain; Region: NusA_N; pfam08529 243233003620 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243233003621 RNA binding site [nucleotide binding]; other site 243233003622 homodimer interface [polypeptide binding]; other site 243233003623 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243233003624 G-X-X-G motif; other site 243233003625 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243233003626 G-X-X-G motif; other site 243233003627 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243233003628 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 243233003629 ribosome maturation protein RimP; Reviewed; Region: PRK00092 243233003630 Sm and related proteins; Region: Sm_like; cl00259 243233003631 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 243233003632 putative oligomer interface [polypeptide binding]; other site 243233003633 putative RNA binding site [nucleotide binding]; other site 243233003634 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243233003635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243233003636 putative active site [active] 243233003637 putative metal binding site [ion binding]; other site 243233003638 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243233003639 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 243233003640 motif 1; other site 243233003641 dimer interface [polypeptide binding]; other site 243233003642 active site 243233003643 motif 2; other site 243233003644 motif 3; other site 243233003645 elongation factor P; Validated; Region: PRK00529 243233003646 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243233003647 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243233003648 RNA binding site [nucleotide binding]; other site 243233003649 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243233003650 RNA binding site [nucleotide binding]; other site 243233003651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 243233003652 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243233003653 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 243233003654 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 243233003655 nucleotide binding site/active site [active] 243233003656 recombination protein RecR; Reviewed; Region: recR; PRK00076 243233003657 RecR protein; Region: RecR; pfam02132 243233003658 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243233003659 putative active site [active] 243233003660 putative metal-binding site [ion binding]; other site 243233003661 tetramer interface [polypeptide binding]; other site 243233003662 hypothetical protein; Validated; Region: PRK00153 243233003663 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 243233003664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233003665 Walker A motif; other site 243233003666 ATP binding site [chemical binding]; other site 243233003667 Walker B motif; other site 243233003668 arginine finger; other site 243233003669 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243233003670 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 243233003671 Peptidase family M48; Region: Peptidase_M48; pfam01435 243233003672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233003673 TPR motif; other site 243233003674 binding surface 243233003675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233003676 TPR motif; other site 243233003677 binding surface 243233003678 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 243233003679 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 243233003680 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 243233003681 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 243233003682 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 243233003683 Chorismate lyase; Region: Chor_lyase; cl01230 243233003684 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 243233003685 UbiA prenyltransferase family; Region: UbiA; pfam01040 243233003686 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243233003687 signal recognition particle protein; Provisional; Region: PRK10867 243233003688 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243233003689 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243233003690 P loop; other site 243233003691 GTP binding site [chemical binding]; other site 243233003692 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243233003693 putative transcriptional regulator MerR; Provisional; Region: PRK13752 243233003694 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 243233003695 DNA binding residues [nucleotide binding] 243233003696 dimer interface [polypeptide binding]; other site 243233003697 mercury binding site [ion binding]; other site 243233003698 putative mercuric reductase; Provisional; Region: PRK13748 243233003699 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243233003700 metal-binding site [ion binding] 243233003701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233003702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233003703 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243233003704 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 243233003705 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 243233003706 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243233003707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243233003708 active site 243233003709 Int/Topo IB signature motif; other site 243233003710 DNA binding site [nucleotide binding] 243233003711 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 243233003712 Sodium Bile acid symporter family; Region: SBF; cl17470 243233003713 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243233003714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233003715 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243233003716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233003717 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243233003718 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243233003719 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243233003720 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 243233003721 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 243233003722 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 243233003723 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 243233003724 4Fe-4S binding domain; Region: Fer4; pfam00037 243233003725 4Fe-4S binding domain; Region: Fer4; pfam00037 243233003726 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243233003727 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233003728 NADH dehydrogenase subunit G; Validated; Region: PRK08166 243233003729 catalytic loop [active] 243233003730 iron binding site [ion binding]; other site 243233003731 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243233003732 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 243233003733 [4Fe-4S] binding site [ion binding]; other site 243233003734 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 243233003735 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 243233003736 SLBB domain; Region: SLBB; pfam10531 243233003737 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243233003738 NADH dehydrogenase subunit E; Validated; Region: PRK07539 243233003739 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243233003740 putative dimer interface [polypeptide binding]; other site 243233003741 [2Fe-2S] cluster binding site [ion binding]; other site 243233003742 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 243233003743 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 243233003744 NADH dehydrogenase subunit D; Validated; Region: PRK06075 243233003745 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243233003746 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 243233003747 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233003748 Protein export membrane protein; Region: SecD_SecF; cl14618 243233003749 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 243233003750 Protein export membrane protein; Region: SecD_SecF; cl14618 243233003751 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233003752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243233003753 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233003754 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243233003755 Helix-turn-helix domain; Region: HTH_25; pfam13413 243233003756 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 243233003757 Flagellin N-methylase; Region: FliB; pfam03692 243233003758 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243233003759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233003760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233003761 ABC transporter; Region: ABC_tran_2; pfam12848 243233003762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233003763 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 243233003764 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 243233003765 heme binding site [chemical binding]; other site 243233003766 ferroxidase pore; other site 243233003767 ferroxidase diiron center [ion binding]; other site 243233003768 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 243233003769 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243233003770 active site 243233003771 catalytic residues [active] 243233003772 metal binding site [ion binding]; metal-binding site 243233003773 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 243233003774 dimer interface [polypeptide binding]; other site 243233003775 FMN binding site [chemical binding]; other site 243233003776 NADPH bind site [chemical binding]; other site 243233003777 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 243233003778 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 243233003779 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 243233003780 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243233003781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243233003782 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 243233003783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243233003784 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243233003785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233003786 dimer interface [polypeptide binding]; other site 243233003787 conserved gate region; other site 243233003788 putative PBP binding loops; other site 243233003789 ABC-ATPase subunit interface; other site 243233003790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233003791 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 243233003792 Walker A/P-loop; other site 243233003793 ATP binding site [chemical binding]; other site 243233003794 Q-loop/lid; other site 243233003795 ABC transporter signature motif; other site 243233003796 Walker B; other site 243233003797 D-loop; other site 243233003798 H-loop/switch region; other site 243233003799 TOBE domain; Region: TOBE; pfam03459 243233003800 TOBE domain; Region: TOBE; cl01440 243233003801 molybdenum-pterin binding domain; Region: Mop; TIGR00638 243233003802 heat shock protein HtpX; Provisional; Region: PRK05457 243233003803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233003804 DNA repair protein RadA; Provisional; Region: PRK11823 243233003805 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 243233003806 Walker A motif/ATP binding site; other site 243233003807 ATP binding site [chemical binding]; other site 243233003808 Walker B motif; other site 243233003809 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243233003810 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 243233003811 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243233003812 active site 243233003813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243233003814 dimerization interface [polypeptide binding]; other site 243233003815 putative DNA binding site [nucleotide binding]; other site 243233003816 putative Zn2+ binding site [ion binding]; other site 243233003817 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 243233003818 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 243233003819 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 243233003820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233003821 catalytic loop [active] 243233003822 iron binding site [ion binding]; other site 243233003823 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243233003824 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 243233003825 [4Fe-4S] binding site [ion binding]; other site 243233003826 molybdopterin cofactor binding site; other site 243233003827 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 243233003828 molybdopterin cofactor binding site; other site 243233003829 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 243233003830 putative dimer interface [polypeptide binding]; other site 243233003831 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243233003832 SLBB domain; Region: SLBB; pfam10531 243233003833 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243233003834 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 243233003835 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 243233003836 putative dimer interface [polypeptide binding]; other site 243233003837 [2Fe-2S] cluster binding site [ion binding]; other site 243233003838 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 243233003839 G1 box; other site 243233003840 GTP/Mg2+ binding site [chemical binding]; other site 243233003841 G2 box; other site 243233003842 Switch I region; other site 243233003843 G3 box; other site 243233003844 Switch II region; other site 243233003845 G4 box; other site 243233003846 G5 box; other site 243233003847 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243233003848 HSP70 interaction site [polypeptide binding]; other site 243233003849 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 243233003850 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 243233003851 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243233003852 Walker A/P-loop; other site 243233003853 ATP binding site [chemical binding]; other site 243233003854 Q-loop/lid; other site 243233003855 ABC transporter signature motif; other site 243233003856 Walker B; other site 243233003857 D-loop; other site 243233003858 H-loop/switch region; other site 243233003859 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 243233003860 active site 243233003861 catalytic triad [active] 243233003862 oxyanion hole [active] 243233003863 switch loop; other site 243233003864 HopJ type III effector protein; Region: HopJ; pfam08888 243233003865 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 243233003866 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233003867 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233003868 catalytic residue [active] 243233003869 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243233003870 FAD binding domain; Region: FAD_binding_4; pfam01565 243233003871 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 243233003872 homodimer interface [polypeptide binding]; other site 243233003873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233003874 catalytic residue [active] 243233003875 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243233003876 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 243233003877 dimerization interface [polypeptide binding]; other site 243233003878 ligand binding site [chemical binding]; other site 243233003879 NADP binding site [chemical binding]; other site 243233003880 catalytic site [active] 243233003881 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 243233003882 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243233003883 active site 243233003884 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 243233003885 tetratricopeptide repeat protein; Provisional; Region: PRK11788 243233003886 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243233003887 IHF dimer interface [polypeptide binding]; other site 243233003888 IHF - DNA interface [nucleotide binding]; other site 243233003889 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 243233003890 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 243233003891 RNA binding site [nucleotide binding]; other site 243233003892 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243233003893 RNA binding site [nucleotide binding]; other site 243233003894 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243233003895 RNA binding site [nucleotide binding]; other site 243233003896 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 243233003897 RNA binding site [nucleotide binding]; other site 243233003898 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 243233003899 RNA binding site [nucleotide binding]; other site 243233003900 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 243233003901 RNA binding site [nucleotide binding]; other site 243233003902 cytidylate kinase; Provisional; Region: cmk; PRK00023 243233003903 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243233003904 CMP-binding site; other site 243233003905 The sites determining sugar specificity; other site 243233003906 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243233003907 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243233003908 hinge; other site 243233003909 active site 243233003910 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 243233003911 prephenate dehydrogenase; Validated; Region: PRK08507 243233003912 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 243233003913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233003914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233003915 homodimer interface [polypeptide binding]; other site 243233003916 catalytic residue [active] 243233003917 Chorismate mutase type II; Region: CM_2; cl00693 243233003918 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 243233003919 Prephenate dehydratase; Region: PDT; pfam00800 243233003920 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243233003921 putative L-Phe binding site [chemical binding]; other site 243233003922 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 243233003923 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243233003924 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 243233003925 homodimer interface [polypeptide binding]; other site 243233003926 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 243233003927 substrate-cofactor binding pocket; other site 243233003928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233003929 catalytic residue [active] 243233003930 DNA gyrase subunit A; Validated; Region: PRK05560 243233003931 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243233003932 CAP-like domain; other site 243233003933 active site 243233003934 primary dimer interface [polypeptide binding]; other site 243233003935 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243233003936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243233003937 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243233003938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243233003939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243233003940 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 243233003941 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243233003942 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243233003943 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 243233003944 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 243233003945 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 243233003946 trimer interface [polypeptide binding]; other site 243233003947 active site 243233003948 substrate binding site [chemical binding]; other site 243233003949 CoA binding site [chemical binding]; other site 243233003950 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233003951 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233003952 active site 243233003953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233003954 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233003955 chain length determinant protein EpsF; Region: EpsF; TIGR03017 243233003956 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 243233003957 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 243233003958 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243233003959 SLBB domain; Region: SLBB; pfam10531 243233003960 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243233003961 anti sigma factor interaction site; other site 243233003962 regulatory phosphorylation site [posttranslational modification]; other site 243233003963 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 243233003964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233003965 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 243233003966 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 243233003967 putative ADP-binding pocket [chemical binding]; other site 243233003968 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233003969 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 243233003970 DXD motif; other site 243233003971 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233003972 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243233003973 Probable Catalytic site; other site 243233003974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233003975 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 243233003976 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243233003977 trimer interface [polypeptide binding]; other site 243233003978 active site 243233003979 substrate binding site [chemical binding]; other site 243233003980 CoA binding site [chemical binding]; other site 243233003981 Bacterial sugar transferase; Region: Bac_transf; cl00939 243233003982 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 243233003983 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 243233003984 Predicted integral membrane protein [Function unknown]; Region: COG5542 243233003985 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243233003986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233003987 active site 243233003988 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243233003989 Bacterial sugar transferase; Region: Bac_transf; cl00939 243233003990 Response regulator receiver domain; Region: Response_reg; pfam00072 243233003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233003992 active site 243233003993 phosphorylation site [posttranslational modification] 243233003994 intermolecular recognition site; other site 243233003995 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243233003996 dimerization interface [polypeptide binding]; other site 243233003997 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243233003998 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233003999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233004000 S-adenosylmethionine binding site [chemical binding]; other site 243233004001 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 243233004002 active site clefts [active] 243233004003 zinc binding site [ion binding]; other site 243233004004 dimer interface [polypeptide binding]; other site 243233004005 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243233004006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243233004007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243233004008 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 243233004009 coenzyme PQQ precursor peptide PqqA; Region: PQQ_syn_pqqA; TIGR02107 243233004010 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 243233004011 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 243233004012 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 243233004013 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 243233004014 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 243233004015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233004016 FeS/SAM binding site; other site 243233004017 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243233004018 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 243233004019 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 243233004020 Lipopolysaccharide-assembly; Region: LptE; cl01125 243233004021 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243233004022 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243233004023 HIGH motif; other site 243233004024 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243233004025 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243233004026 active site 243233004027 KMSKS motif; other site 243233004028 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243233004029 tRNA binding surface [nucleotide binding]; other site 243233004030 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243233004031 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243233004032 P-loop; other site 243233004033 Magnesium ion binding site [ion binding]; other site 243233004034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243233004035 Magnesium ion binding site [ion binding]; other site 243233004036 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 243233004037 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 243233004038 putative active site [active] 243233004039 catalytic triad [active] 243233004040 putative dimer interface [polypeptide binding]; other site 243233004041 FOG: CBS domain [General function prediction only]; Region: COG0517 243233004042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243233004043 Transporter associated domain; Region: CorC_HlyC; smart01091 243233004044 metal-binding heat shock protein; Provisional; Region: PRK00016 243233004045 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 243233004046 PhoH-like protein; Region: PhoH; pfam02562 243233004047 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 243233004048 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243233004049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233004050 FeS/SAM binding site; other site 243233004051 TRAM domain; Region: TRAM; pfam01938 243233004052 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 243233004053 Recombination protein O N terminal; Region: RecO_N; pfam11967 243233004054 Recombination protein O C terminal; Region: RecO_C; pfam02565 243233004055 GTPase Era; Reviewed; Region: era; PRK00089 243233004056 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 243233004057 G1 box; other site 243233004058 GTP/Mg2+ binding site [chemical binding]; other site 243233004059 Switch I region; other site 243233004060 G2 box; other site 243233004061 Switch II region; other site 243233004062 G3 box; other site 243233004063 G4 box; other site 243233004064 G5 box; other site 243233004065 KH domain; Region: KH_2; pfam07650 243233004066 ribonuclease III; Reviewed; Region: rnc; PRK00102 243233004067 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243233004068 dimerization interface [polypeptide binding]; other site 243233004069 active site 243233004070 metal binding site [ion binding]; metal-binding site 243233004071 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243233004072 dsRNA binding site [nucleotide binding]; other site 243233004073 signal peptidase I; Provisional; Region: PRK10861 243233004074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243233004075 Catalytic site [active] 243233004076 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243233004077 GTP-binding protein LepA; Provisional; Region: PRK05433 243233004078 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243233004079 G1 box; other site 243233004080 putative GEF interaction site [polypeptide binding]; other site 243233004081 GTP/Mg2+ binding site [chemical binding]; other site 243233004082 Switch I region; other site 243233004083 G2 box; other site 243233004084 G3 box; other site 243233004085 Switch II region; other site 243233004086 G4 box; other site 243233004087 G5 box; other site 243233004088 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243233004089 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243233004090 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243233004091 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243233004092 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243233004093 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233004094 protein binding site [polypeptide binding]; other site 243233004095 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233004096 protein binding site [polypeptide binding]; other site 243233004097 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 243233004098 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 243233004099 anti-sigma E factor; Provisional; Region: rseB; PRK09455 243233004100 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 243233004101 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 243233004102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243233004103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243233004104 DNA binding residues [nucleotide binding] 243233004105 L-aspartate oxidase; Provisional; Region: PRK09077 243233004106 L-aspartate oxidase; Provisional; Region: PRK06175 243233004107 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243233004108 4-alpha-glucanotransferase; Provisional; Region: PRK14508 243233004109 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 243233004110 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 243233004111 ligand binding site; other site 243233004112 oligomer interface; other site 243233004113 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 243233004114 dimer interface [polypeptide binding]; other site 243233004115 N-terminal domain interface [polypeptide binding]; other site 243233004116 sulfate 1 binding site; other site 243233004117 glycogen branching enzyme; Provisional; Region: PRK05402 243233004118 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 243233004119 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 243233004120 active site 243233004121 catalytic site [active] 243233004122 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 243233004123 glycogen synthase; Provisional; Region: glgA; PRK00654 243233004124 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243233004125 ADP-binding pocket [chemical binding]; other site 243233004126 homodimer interface [polypeptide binding]; other site 243233004127 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243233004128 dimer interface [polypeptide binding]; other site 243233004129 ADP-ribose binding site [chemical binding]; other site 243233004130 active site 243233004131 nudix motif; other site 243233004132 metal binding site [ion binding]; metal-binding site 243233004133 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243233004134 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 243233004135 tandem repeat interface [polypeptide binding]; other site 243233004136 oligomer interface [polypeptide binding]; other site 243233004137 active site residues [active] 243233004138 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 243233004139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243233004140 RNA binding surface [nucleotide binding]; other site 243233004141 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243233004142 active site 243233004143 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 243233004144 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243233004145 homodimer interface [polypeptide binding]; other site 243233004146 oligonucleotide binding site [chemical binding]; other site 243233004147 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 243233004148 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233004149 ATP binding site [chemical binding]; other site 243233004150 putative Mg++ binding site [ion binding]; other site 243233004151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233004152 nucleotide binding region [chemical binding]; other site 243233004153 ATP-binding site [chemical binding]; other site 243233004154 Helicase associated domain (HA2); Region: HA2; pfam04408 243233004155 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 243233004156 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 243233004157 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243233004158 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243233004159 nodulation ABC transporter NodI; Provisional; Region: PRK13537 243233004160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233004161 Walker A/P-loop; other site 243233004162 ATP binding site [chemical binding]; other site 243233004163 Q-loop/lid; other site 243233004164 ABC transporter signature motif; other site 243233004165 Walker B; other site 243233004166 D-loop; other site 243233004167 H-loop/switch region; other site 243233004168 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 243233004169 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 243233004170 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 243233004171 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 243233004172 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 243233004173 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 243233004174 active site 243233004175 substrate binding site [chemical binding]; other site 243233004176 trimer interface [polypeptide binding]; other site 243233004177 CoA binding site [chemical binding]; other site 243233004178 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 243233004179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233004181 homodimer interface [polypeptide binding]; other site 243233004182 catalytic residue [active] 243233004183 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 243233004184 Cellulose binding domain; Region: CBM_2; pfam00553 243233004185 Cellulose binding domain; Region: CBM_2; pfam00553 243233004186 Cellulose binding domain; Region: CBM_2; pfam00553 243233004187 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243233004188 Interdomain contacts; other site 243233004189 Cytokine receptor motif; other site 243233004190 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 243233004191 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 243233004192 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 243233004193 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 243233004194 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 243233004195 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 243233004196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243233004197 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 243233004198 homotrimer interaction site [polypeptide binding]; other site 243233004199 putative active site [active] 243233004200 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243233004201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243233004202 putative acyl-acceptor binding pocket; other site 243233004203 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233004204 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243233004205 Ligand binding site; other site 243233004206 Putative Catalytic site; other site 243233004207 DXD motif; other site 243233004208 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243233004209 nucleoside/Zn binding site; other site 243233004210 dimer interface [polypeptide binding]; other site 243233004211 catalytic motif [active] 243233004212 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 243233004213 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243233004214 Cysteine-rich domain; Region: CCG; pfam02754 243233004215 Cysteine-rich domain; Region: CCG; pfam02754 243233004216 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 243233004217 FAD binding domain; Region: FAD_binding_4; pfam01565 243233004218 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 243233004219 FAD binding domain; Region: FAD_binding_4; pfam01565 243233004220 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243233004221 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 243233004222 Moco binding site; other site 243233004223 metal coordination site [ion binding]; other site 243233004224 dimerization interface [polypeptide binding]; other site 243233004225 BT1 family; Region: BT1; pfam03092 243233004226 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 243233004227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243233004228 active site 243233004229 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 243233004230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004231 binding surface 243233004232 TPR motif; other site 243233004233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004234 binding surface 243233004235 TPR motif; other site 243233004236 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 243233004237 Pilin (bacterial filament); Region: Pilin; pfam00114 243233004238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004239 TPR motif; other site 243233004240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243233004241 binding surface 243233004242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004243 binding surface 243233004244 TPR motif; other site 243233004245 TPR repeat; Region: TPR_11; pfam13414 243233004246 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243233004247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004248 binding surface 243233004249 TPR motif; other site 243233004250 TPR repeat; Region: TPR_11; pfam13414 243233004251 TPR repeat; Region: TPR_11; pfam13414 243233004252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004253 binding surface 243233004254 TPR motif; other site 243233004255 TPR repeat; Region: TPR_11; pfam13414 243233004256 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 243233004257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233004258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233004259 Transposase domain (DUF772); Region: DUF772; pfam05598 243233004260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233004261 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233004262 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 243233004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233004264 S-adenosylmethionine binding site [chemical binding]; other site 243233004265 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233004266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004267 TPR repeat; Region: TPR_11; pfam13414 243233004268 binding surface 243233004269 Transposase domain (DUF772); Region: DUF772; pfam05598 243233004270 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233004271 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233004272 TPR repeat; Region: TPR_11; pfam13414 243233004273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004274 binding surface 243233004275 TPR motif; other site 243233004276 TPR repeat; Region: TPR_11; pfam13414 243233004277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233004278 binding surface 243233004279 TPR motif; other site 243233004280 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243233004281 putative cation:proton antiport protein; Provisional; Region: PRK10669 243233004282 TrkA-N domain; Region: TrkA_N; pfam02254 243233004283 metabolite-proton symporter; Region: 2A0106; TIGR00883 243233004284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233004285 putative substrate translocation pore; other site 243233004286 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 243233004287 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 243233004288 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243233004289 DNA-binding site [nucleotide binding]; DNA binding site 243233004290 RNA-binding motif; other site 243233004291 MoxR-like ATPases [General function prediction only]; Region: COG0714 243233004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233004293 Walker A motif; other site 243233004294 ATP binding site [chemical binding]; other site 243233004295 Walker B motif; other site 243233004296 arginine finger; other site 243233004297 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243233004298 Protein of unknown function DUF58; Region: DUF58; pfam01882 243233004299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243233004300 metal ion-dependent adhesion site (MIDAS); other site 243233004301 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243233004302 metal ion-dependent adhesion site (MIDAS); other site 243233004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233004304 S-adenosylmethionine binding site [chemical binding]; other site 243233004305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004306 PAS fold; Region: PAS_3; pfam08447 243233004307 putative active site [active] 243233004308 heme pocket [chemical binding]; other site 243233004309 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 243233004310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004311 putative active site [active] 243233004312 heme pocket [chemical binding]; other site 243233004313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004314 putative active site [active] 243233004315 heme pocket [chemical binding]; other site 243233004316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004317 putative active site [active] 243233004318 heme pocket [chemical binding]; other site 243233004319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233004320 metal binding site [ion binding]; metal-binding site 243233004321 active site 243233004322 I-site; other site 243233004323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233004324 YGGT family; Region: YGGT; pfam02325 243233004325 YGGT family; Region: YGGT; pfam02325 243233004326 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 243233004327 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 243233004328 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 243233004329 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243233004330 catalytic residue [active] 243233004331 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 243233004332 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243233004333 Walker A motif; other site 243233004334 ATP binding site [chemical binding]; other site 243233004335 Walker B motif; other site 243233004336 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243233004337 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243233004338 Walker A motif; other site 243233004339 ATP binding site [chemical binding]; other site 243233004340 Walker B motif; other site 243233004341 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243233004342 metal ion-dependent adhesion site (MIDAS); other site 243233004343 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 243233004344 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 243233004345 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233004346 catalytic loop [active] 243233004347 iron binding site [ion binding]; other site 243233004348 fumarate hydratase; Reviewed; Region: fumC; PRK00485 243233004349 Class II fumarases; Region: Fumarase_classII; cd01362 243233004350 active site 243233004351 tetramer interface [polypeptide binding]; other site 243233004352 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 243233004353 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 243233004354 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 243233004355 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 243233004356 substrate binding pocket [chemical binding]; other site 243233004357 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 243233004358 B12 binding site [chemical binding]; other site 243233004359 cobalt ligand [ion binding]; other site 243233004360 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 243233004361 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 243233004362 Iron-sulfur protein interface; other site 243233004363 proximal quinone binding site [chemical binding]; other site 243233004364 SdhD (CybS) interface [polypeptide binding]; other site 243233004365 proximal heme binding site [chemical binding]; other site 243233004366 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 243233004367 putative SdhC subunit interface [polypeptide binding]; other site 243233004368 putative proximal heme binding site [chemical binding]; other site 243233004369 putative Iron-sulfur protein interface [polypeptide binding]; other site 243233004370 putative proximal quinone binding site; other site 243233004371 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 243233004372 L-aspartate oxidase; Provisional; Region: PRK06175 243233004373 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243233004374 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 243233004375 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 243233004376 ArsC family; Region: ArsC; pfam03960 243233004377 putative catalytic residues [active] 243233004378 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 243233004379 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 243233004380 metal binding site [ion binding]; metal-binding site 243233004381 dimer interface [polypeptide binding]; other site 243233004382 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243233004383 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243233004384 active site residue [active] 243233004385 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 243233004386 active site residue [active] 243233004387 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 243233004388 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243233004389 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243233004390 alpha subunit interaction interface [polypeptide binding]; other site 243233004391 Walker A motif; other site 243233004392 ATP binding site [chemical binding]; other site 243233004393 Walker B motif; other site 243233004394 inhibitor binding site; inhibition site 243233004395 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243233004396 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243233004397 LBP interface [polypeptide binding]; other site 243233004398 gamma subunit interface [polypeptide binding]; other site 243233004399 epsilon subunit interface [polypeptide binding]; other site 243233004400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233004401 S-adenosylmethionine binding site [chemical binding]; other site 243233004402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233004403 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243233004404 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243233004405 Walker A/P-loop; other site 243233004406 ATP binding site [chemical binding]; other site 243233004407 Q-loop/lid; other site 243233004408 ABC transporter signature motif; other site 243233004409 Walker B; other site 243233004410 D-loop; other site 243233004411 H-loop/switch region; other site 243233004412 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 243233004413 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 243233004414 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 243233004415 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 243233004416 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 243233004417 heme-binding site [chemical binding]; other site 243233004418 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243233004419 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243233004420 dimer interface [polypeptide binding]; other site 243233004421 putative functional site; other site 243233004422 putative MPT binding site; other site 243233004423 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 243233004424 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 243233004425 acyl-activating enzyme (AAE) consensus motif; other site 243233004426 putative AMP binding site [chemical binding]; other site 243233004427 putative active site [active] 243233004428 putative CoA binding site [chemical binding]; other site 243233004429 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233004430 putative Mg++ binding site [ion binding]; other site 243233004431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233004432 nucleotide binding region [chemical binding]; other site 243233004433 ATP-binding site [chemical binding]; other site 243233004434 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 243233004435 putative RNA binding site [nucleotide binding]; other site 243233004436 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243233004437 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243233004438 putative NAD(P) binding site [chemical binding]; other site 243233004439 putative substrate binding site [chemical binding]; other site 243233004440 catalytic Zn binding site [ion binding]; other site 243233004441 structural Zn binding site [ion binding]; other site 243233004442 dimer interface [polypeptide binding]; other site 243233004443 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 243233004444 Transglycosylase; Region: Transgly; pfam00912 243233004445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243233004446 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 243233004447 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 243233004448 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 243233004449 beta-galactosidase; Region: BGL; TIGR03356 243233004450 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 243233004451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233004452 ATP binding site [chemical binding]; other site 243233004453 putative Mg++ binding site [ion binding]; other site 243233004454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233004455 nucleotide binding region [chemical binding]; other site 243233004456 ATP-binding site [chemical binding]; other site 243233004457 DEAD/H associated; Region: DEAD_assoc; pfam08494 243233004458 Transposase domain (DUF772); Region: DUF772; pfam05598 243233004459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233004460 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233004461 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243233004462 MASE1; Region: MASE1; pfam05231 243233004463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233004464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233004465 metal binding site [ion binding]; metal-binding site 243233004466 active site 243233004467 I-site; other site 243233004468 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 243233004469 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 243233004470 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 243233004471 putative phosphoketolase; Provisional; Region: PRK05261 243233004472 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 243233004473 TPP-binding site; other site 243233004474 XFP C-terminal domain; Region: XFP_C; pfam09363 243233004475 propionate/acetate kinase; Provisional; Region: PRK12379 243233004476 Acetokinase family; Region: Acetate_kinase; cl17229 243233004477 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 243233004478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243233004479 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243233004480 active site 243233004481 Staphylococcal nuclease homologues; Region: SNc; smart00318 243233004482 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 243233004483 Catalytic site; other site 243233004484 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 243233004485 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 243233004486 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243233004487 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233004488 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243233004489 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233004490 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233004491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243233004492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243233004493 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 243233004494 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243233004495 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243233004496 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233004497 protein binding site [polypeptide binding]; other site 243233004498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233004499 protein binding site [polypeptide binding]; other site 243233004500 HupF/HypC family; Region: HupF_HypC; pfam01455 243233004501 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 243233004502 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 243233004503 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243233004504 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 243233004505 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 243233004506 Acylphosphatase; Region: Acylphosphatase; pfam00708 243233004507 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 243233004508 HypF finger; Region: zf-HYPF; pfam07503 243233004509 HypF finger; Region: zf-HYPF; pfam07503 243233004510 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 243233004511 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 243233004512 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 243233004513 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 243233004514 LabA_like proteins; Region: LabA_like; cd06167 243233004515 putative metal binding site [ion binding]; other site 243233004516 Uncharacterized conserved protein [Function unknown]; Region: COG1432 243233004517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243233004518 DNA-binding site [nucleotide binding]; DNA binding site 243233004519 RNA-binding motif; other site 243233004520 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243233004521 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 243233004522 catalytic residues [active] 243233004523 catalytic nucleophile [active] 243233004524 Presynaptic Site I dimer interface [polypeptide binding]; other site 243233004525 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 243233004526 Synaptic Flat tetramer interface [polypeptide binding]; other site 243233004527 Synaptic Site I dimer interface [polypeptide binding]; other site 243233004528 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243233004529 DNA-binding interface [nucleotide binding]; DNA binding site 243233004530 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 243233004531 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 243233004532 cofactor binding site; other site 243233004533 DNA binding site [nucleotide binding] 243233004534 substrate interaction site [chemical binding]; other site 243233004535 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 243233004536 additional DNA contacts [nucleotide binding]; other site 243233004537 mismatch recognition site; other site 243233004538 active site 243233004539 zinc binding site [ion binding]; other site 243233004540 DNA intercalation site [nucleotide binding]; other site 243233004541 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 243233004542 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243233004543 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243233004544 HTH-like domain; Region: HTH_21; pfam13276 243233004545 Integrase core domain; Region: rve; pfam00665 243233004546 Integrase core domain; Region: rve_3; pfam13683 243233004547 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 243233004548 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243233004549 oligomeric interface; other site 243233004550 putative active site [active] 243233004551 homodimer interface [polypeptide binding]; other site 243233004552 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243233004553 putative active site [active] 243233004554 NAD-dependent deacetylase; Provisional; Region: PRK00481 243233004555 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 243233004556 NAD+ binding site [chemical binding]; other site 243233004557 substrate binding site [chemical binding]; other site 243233004558 Zn binding site [ion binding]; other site 243233004559 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 243233004560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233004561 Walker A motif; other site 243233004562 ATP binding site [chemical binding]; other site 243233004563 Walker B motif; other site 243233004564 arginine finger; other site 243233004565 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243233004566 DnaA box-binding interface [nucleotide binding]; other site 243233004567 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243233004568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243233004569 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 243233004570 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 243233004571 ATP cone domain; Region: ATP-cone; pfam03477 243233004572 ATP cone domain; Region: ATP-cone; pfam03477 243233004573 Class I ribonucleotide reductase; Region: RNR_I; cd01679 243233004574 active site 243233004575 dimer interface [polypeptide binding]; other site 243233004576 catalytic residues [active] 243233004577 effector binding site; other site 243233004578 R2 peptide binding site; other site 243233004579 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 243233004580 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 243233004581 dimer interface [polypeptide binding]; other site 243233004582 putative radical transfer pathway; other site 243233004583 diiron center [ion binding]; other site 243233004584 tyrosyl radical; other site 243233004585 VanZ like family; Region: VanZ; pfam04892 243233004586 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 243233004587 Fatty acid desaturase; Region: FA_desaturase; pfam00487 243233004588 Di-iron ligands [ion binding]; other site 243233004589 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 243233004590 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 243233004591 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 243233004592 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 243233004593 BolA-like protein; Region: BolA; pfam01722 243233004594 YciI-like protein; Reviewed; Region: PRK11370 243233004595 intracellular septation protein A; Reviewed; Region: PRK00259 243233004596 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 243233004597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243233004598 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 243233004599 dimer interface [polypeptide binding]; other site 243233004600 active site 243233004601 metal binding site [ion binding]; metal-binding site 243233004602 glutathione binding site [chemical binding]; other site 243233004603 PAS fold; Region: PAS_4; pfam08448 243233004604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004605 putative active site [active] 243233004606 heme pocket [chemical binding]; other site 243233004607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004608 PAS domain; Region: PAS_9; pfam13426 243233004609 putative active site [active] 243233004610 heme pocket [chemical binding]; other site 243233004611 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233004612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233004613 metal binding site [ion binding]; metal-binding site 243233004614 active site 243233004615 I-site; other site 243233004616 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233004617 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 243233004618 tetramer interfaces [polypeptide binding]; other site 243233004619 binuclear metal-binding site [ion binding]; other site 243233004620 thiamine monophosphate kinase; Provisional; Region: PRK05731 243233004621 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243233004622 ATP binding site [chemical binding]; other site 243233004623 dimerization interface [polypeptide binding]; other site 243233004624 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 243233004625 putative RNA binding site [nucleotide binding]; other site 243233004626 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243233004627 homopentamer interface [polypeptide binding]; other site 243233004628 active site 243233004629 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 243233004630 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243233004631 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 243233004632 dimerization interface [polypeptide binding]; other site 243233004633 active site 243233004634 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243233004635 Lumazine binding domain; Region: Lum_binding; pfam00677 243233004636 Lumazine binding domain; Region: Lum_binding; pfam00677 243233004637 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 243233004638 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243233004639 catalytic motif [active] 243233004640 Zn binding site [ion binding]; other site 243233004641 RibD C-terminal domain; Region: RibD_C; cl17279 243233004642 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243233004643 ATP cone domain; Region: ATP-cone; pfam03477 243233004644 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 243233004645 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243233004646 dimer interface [polypeptide binding]; other site 243233004647 active site 243233004648 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243233004649 folate binding site [chemical binding]; other site 243233004650 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243233004651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243233004652 dimer interface [polypeptide binding]; other site 243233004653 putative CheW interface [polypeptide binding]; other site 243233004654 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 243233004655 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 243233004656 putative ligand binding site [chemical binding]; other site 243233004657 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243233004658 anti sigma factor interaction site; other site 243233004659 regulatory phosphorylation site [posttranslational modification]; other site 243233004660 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 243233004661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 243233004662 active site clefts [active] 243233004663 zinc binding site [ion binding]; other site 243233004664 dimer interface [polypeptide binding]; other site 243233004665 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243233004666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 243233004667 ATP binding site [chemical binding]; other site 243233004668 Mg2+ binding site [ion binding]; other site 243233004669 G-X-G motif; other site 243233004670 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 243233004671 active site 243233004672 hydrophilic channel; other site 243233004673 dimerization interface [polypeptide binding]; other site 243233004674 catalytic residues [active] 243233004675 active site lid [active] 243233004676 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 243233004677 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243233004678 FMN binding site [chemical binding]; other site 243233004679 active site 243233004680 catalytic residues [active] 243233004681 substrate binding site [chemical binding]; other site 243233004682 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 243233004683 GTP cyclohydrolase I; Provisional; Region: PLN03044 243233004684 homodecamer interface [polypeptide binding]; other site 243233004685 active site 243233004686 putative catalytic site residues [active] 243233004687 zinc binding site [ion binding]; other site 243233004688 GTP-CH-I/GFRP interaction surface; other site 243233004689 ferrochelatase; Reviewed; Region: hemH; PRK00035 243233004690 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243233004691 C-terminal domain interface [polypeptide binding]; other site 243233004692 active site 243233004693 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243233004694 active site 243233004695 N-terminal domain interface [polypeptide binding]; other site 243233004696 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 243233004697 Transglycosylase; Region: Transgly; pfam00912 243233004698 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243233004699 PAS domain S-box; Region: sensory_box; TIGR00229 243233004700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004701 putative active site [active] 243233004702 heme pocket [chemical binding]; other site 243233004703 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243233004704 GAF domain; Region: GAF; pfam01590 243233004705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004706 PAS fold; Region: PAS_3; pfam08447 243233004707 putative active site [active] 243233004708 heme pocket [chemical binding]; other site 243233004709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004710 PAS domain; Region: PAS_9; pfam13426 243233004711 putative active site [active] 243233004712 heme pocket [chemical binding]; other site 243233004713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233004714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233004715 metal binding site [ion binding]; metal-binding site 243233004716 active site 243233004717 I-site; other site 243233004718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233004719 Cache domain; Region: Cache_1; pfam02743 243233004720 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243233004721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233004722 dimerization interface [polypeptide binding]; other site 243233004723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243233004724 dimer interface [polypeptide binding]; other site 243233004725 putative CheW interface [polypeptide binding]; other site 243233004726 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 243233004727 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 243233004728 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 243233004729 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 243233004730 dimerization interface [polypeptide binding]; other site 243233004731 ATP binding site [chemical binding]; other site 243233004732 glutamine synthetase; Provisional; Region: glnA; PRK09469 243233004733 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243233004734 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243233004735 hypothetical protein; Provisional; Region: PRK08999 243233004736 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 243233004737 active site 243233004738 8-oxo-dGMP binding site [chemical binding]; other site 243233004739 nudix motif; other site 243233004740 metal binding site [ion binding]; metal-binding site 243233004741 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243233004742 thiamine phosphate binding site [chemical binding]; other site 243233004743 active site 243233004744 pyrophosphate binding site [ion binding]; other site 243233004745 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243233004746 heterotetramer interface [polypeptide binding]; other site 243233004747 active site pocket [active] 243233004748 cleavage site 243233004749 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 243233004750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243233004751 ATP binding site [chemical binding]; other site 243233004752 putative Mg++ binding site [ion binding]; other site 243233004753 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243233004754 SEC-C motif; Region: SEC-C; pfam02810 243233004755 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243233004756 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243233004757 GIY-YIG motif/motif A; other site 243233004758 active site 243233004759 catalytic site [active] 243233004760 putative DNA binding site [nucleotide binding]; other site 243233004761 metal binding site [ion binding]; metal-binding site 243233004762 UvrB/uvrC motif; Region: UVR; pfam02151 243233004763 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243233004764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243233004765 PAS domain; Region: PAS; smart00091 243233004766 PAS domain S-box; Region: sensory_box; TIGR00229 243233004767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004768 putative active site [active] 243233004769 heme pocket [chemical binding]; other site 243233004770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004771 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243233004772 putative active site [active] 243233004773 heme pocket [chemical binding]; other site 243233004774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004775 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243233004776 putative active site [active] 243233004777 heme pocket [chemical binding]; other site 243233004778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233004779 putative active site [active] 243233004780 heme pocket [chemical binding]; other site 243233004781 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243233004782 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243233004783 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 243233004784 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 243233004785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233004786 ATP binding site [chemical binding]; other site 243233004787 Mg2+ binding site [ion binding]; other site 243233004788 G-X-G motif; other site 243233004789 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243233004790 anti sigma factor interaction site; other site 243233004791 regulatory phosphorylation site [posttranslational modification]; other site 243233004792 Domain of unknown function DUF87; Region: DUF87; pfam01935 243233004793 AAA-like domain; Region: AAA_10; pfam12846 243233004794 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 243233004795 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 243233004796 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 243233004797 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243233004798 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 243233004799 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 243233004800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233004801 ATP binding site [chemical binding]; other site 243233004802 Mg2+ binding site [ion binding]; other site 243233004803 G-X-G motif; other site 243233004804 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 243233004805 ATP binding site [chemical binding]; other site 243233004806 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 243233004807 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 243233004808 thioredoxin reductase; Provisional; Region: PRK10262 243233004809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233004810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233004811 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243233004812 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243233004813 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 243233004814 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 243233004815 putative coenzyme Q binding site [chemical binding]; other site 243233004816 flavodoxin FldA; Validated; Region: PRK09267 243233004817 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243233004818 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 243233004819 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243233004820 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243233004821 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243233004822 ring oligomerisation interface [polypeptide binding]; other site 243233004823 ATP/Mg binding site [chemical binding]; other site 243233004824 stacking interactions; other site 243233004825 hinge regions; other site 243233004826 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243233004827 oligomerisation interface [polypeptide binding]; other site 243233004828 mobile loop; other site 243233004829 roof hairpin; other site 243233004830 Integrase core domain; Region: rve_3; cl15866 243233004831 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 243233004832 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243233004833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233004834 FeS/SAM binding site; other site 243233004835 putative sulfate transport protein CysZ; Validated; Region: PRK04949 243233004836 response regulator GlrR; Provisional; Region: PRK15115 243233004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233004838 active site 243233004839 phosphorylation site [posttranslational modification] 243233004840 intermolecular recognition site; other site 243233004841 dimerization interface [polypeptide binding]; other site 243233004842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233004843 Walker A motif; other site 243233004844 ATP binding site [chemical binding]; other site 243233004845 Walker B motif; other site 243233004846 arginine finger; other site 243233004847 Uncharacterized conserved protein [Function unknown]; Region: COG2433 243233004848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233004849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233004850 dimerization interface [polypeptide binding]; other site 243233004851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233004852 dimer interface [polypeptide binding]; other site 243233004853 phosphorylation site [posttranslational modification] 243233004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233004855 ATP binding site [chemical binding]; other site 243233004856 Mg2+ binding site [ion binding]; other site 243233004857 G-X-G motif; other site 243233004858 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 243233004859 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243233004860 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233004861 active site 243233004862 thymidine phosphorylase; Provisional; Region: PRK04350 243233004863 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243233004864 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243233004865 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 243233004866 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 243233004867 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233004868 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233004869 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233004870 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243233004871 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 243233004872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243233004873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233004874 protein binding site [polypeptide binding]; other site 243233004875 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 243233004876 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243233004877 HSP70 interaction site [polypeptide binding]; other site 243233004878 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243233004879 substrate binding site [polypeptide binding]; other site 243233004880 dimer interface [polypeptide binding]; other site 243233004881 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 243233004882 ZIP Zinc transporter; Region: Zip; pfam02535 243233004883 Uncharacterized conserved protein [Function unknown]; Region: COG3339 243233004884 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243233004885 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243233004886 putative dimer interface [polypeptide binding]; other site 243233004887 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243233004888 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243233004889 putative dimer interface [polypeptide binding]; other site 243233004890 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243233004891 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243233004892 putative dimer interface [polypeptide binding]; other site 243233004893 alanine racemase; Reviewed; Region: alr; PRK00053 243233004894 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 243233004895 active site 243233004896 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243233004897 substrate binding site [chemical binding]; other site 243233004898 catalytic residues [active] 243233004899 dimer interface [polypeptide binding]; other site 243233004900 replicative DNA helicase; Region: DnaB; TIGR00665 243233004901 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243233004902 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243233004903 Walker A motif; other site 243233004904 ATP binding site [chemical binding]; other site 243233004905 Walker B motif; other site 243233004906 DNA binding loops [nucleotide binding] 243233004907 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 243233004908 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 243233004909 putative ribose interaction site [chemical binding]; other site 243233004910 putative ADP binding site [chemical binding]; other site 243233004911 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 243233004912 active site 243233004913 HIGH motif; other site 243233004914 nucleotide binding site [chemical binding]; other site 243233004915 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 243233004916 TAP-like protein; Region: Abhydrolase_4; pfam08386 243233004917 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243233004918 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 243233004919 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243233004920 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243233004921 CoA-ligase; Region: Ligase_CoA; pfam00549 243233004922 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243233004923 CoA binding domain; Region: CoA_binding; smart00881 243233004924 CoA-ligase; Region: Ligase_CoA; pfam00549 243233004925 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243233004926 active site residue [active] 243233004927 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 243233004928 putative active site [active] 243233004929 dimerization interface [polypeptide binding]; other site 243233004930 putative tRNAtyr binding site [nucleotide binding]; other site 243233004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243233004932 Coenzyme A binding pocket [chemical binding]; other site 243233004933 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 243233004934 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243233004935 FMN binding site [chemical binding]; other site 243233004936 active site 243233004937 catalytic residues [active] 243233004938 substrate binding site [chemical binding]; other site 243233004939 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243233004940 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243233004941 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243233004942 purine monophosphate binding site [chemical binding]; other site 243233004943 dimer interface [polypeptide binding]; other site 243233004944 putative catalytic residues [active] 243233004945 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243233004946 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 243233004947 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243233004948 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 243233004949 Cysteine-rich domain; Region: CCG; pfam02754 243233004950 Cysteine-rich domain; Region: CCG; pfam02754 243233004951 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 243233004952 OsmC-like protein; Region: OsmC; cl00767 243233004953 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243233004954 MG2 domain; Region: A2M_N; pfam01835 243233004955 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 243233004956 Alpha-2-macroglobulin family; Region: A2M; pfam00207 243233004957 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243233004958 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243233004959 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 243233004960 succinic semialdehyde dehydrogenase; Region: PLN02278 243233004961 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 243233004962 tetramerization interface [polypeptide binding]; other site 243233004963 NAD(P) binding site [chemical binding]; other site 243233004964 catalytic residues [active] 243233004965 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 243233004966 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243233004967 FAD binding domain; Region: FAD_binding_4; pfam01565 243233004968 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243233004969 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243233004970 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243233004971 Cysteine-rich domain; Region: CCG; pfam02754 243233004972 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 243233004973 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 243233004974 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243233004975 Ligand Binding Site [chemical binding]; other site 243233004976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243233004977 Ligand Binding Site [chemical binding]; other site 243233004978 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243233004979 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 243233004980 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243233004981 TrkA-N domain; Region: TrkA_N; pfam02254 243233004982 TrkA-C domain; Region: TrkA_C; pfam02080 243233004983 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243233004984 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243233004985 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233004986 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243233004987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233004988 motif II; other site 243233004989 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243233004990 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 243233004991 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243233004992 OpgC protein; Region: OpgC_C; pfam10129 243233004993 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 243233004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233004995 active site 243233004996 phosphorylation site [posttranslational modification] 243233004997 intermolecular recognition site; other site 243233004998 dimerization interface [polypeptide binding]; other site 243233004999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233005000 DNA binding site [nucleotide binding] 243233005001 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 243233005002 HAMP domain; Region: HAMP; pfam00672 243233005003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233005004 dimer interface [polypeptide binding]; other site 243233005005 phosphorylation site [posttranslational modification] 243233005006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233005007 ATP binding site [chemical binding]; other site 243233005008 G-X-G motif; other site 243233005009 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243233005010 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233005011 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233005012 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233005013 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243233005014 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243233005015 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243233005016 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243233005017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243233005018 Ligand Binding Site [chemical binding]; other site 243233005019 Cytochrome c; Region: Cytochrom_C; cl11414 243233005020 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243233005021 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243233005022 dimer interface [polypeptide binding]; other site 243233005023 anticodon binding site; other site 243233005024 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243233005025 homodimer interface [polypeptide binding]; other site 243233005026 motif 1; other site 243233005027 active site 243233005028 motif 2; other site 243233005029 GAD domain; Region: GAD; pfam02938 243233005030 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243233005031 motif 3; other site 243233005032 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 243233005033 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 243233005034 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 243233005035 pantothenate kinase; Reviewed; Region: PRK13328 243233005036 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 243233005037 Biotin operon repressor [Transcription]; Region: BirA; COG1654 243233005038 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 243233005039 recombination factor protein RarA; Reviewed; Region: PRK13342 243233005040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005041 Walker A motif; other site 243233005042 ATP binding site [chemical binding]; other site 243233005043 Walker B motif; other site 243233005044 arginine finger; other site 243233005045 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243233005046 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 243233005047 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 243233005048 adenylosuccinate lyase; Provisional; Region: PRK09285 243233005049 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 243233005050 tetramer interface [polypeptide binding]; other site 243233005051 active site 243233005052 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 243233005053 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243233005054 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 243233005055 nudix motif; other site 243233005056 Uncharacterized conserved protein [Function unknown]; Region: COG2127 243233005057 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 243233005058 Clp amino terminal domain; Region: Clp_N; pfam02861 243233005059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005060 Walker A motif; other site 243233005061 ATP binding site [chemical binding]; other site 243233005062 Walker B motif; other site 243233005063 arginine finger; other site 243233005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005065 Walker A motif; other site 243233005066 ATP binding site [chemical binding]; other site 243233005067 Walker B motif; other site 243233005068 arginine finger; other site 243233005069 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243233005070 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243233005071 rRNA binding site [nucleotide binding]; other site 243233005072 predicted 30S ribosome binding site; other site 243233005073 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 243233005074 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 243233005075 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 243233005076 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 243233005077 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 243233005078 Protein of unknown function, DUF482; Region: DUF482; pfam04339 243233005079 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243233005080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233005081 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233005082 ABC transporter; Region: ABC_tran_2; pfam12848 243233005083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243233005084 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 243233005085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005086 Walker A motif; other site 243233005087 ATP binding site [chemical binding]; other site 243233005088 Walker B motif; other site 243233005089 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 243233005090 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 243233005091 Ammonia monooxygenase; Region: AMO; pfam02461 243233005092 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 243233005093 Cytochrome c; Region: Cytochrom_C; cl11414 243233005094 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 243233005095 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 243233005096 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243233005097 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 243233005098 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 243233005099 Dienelactone hydrolase family; Region: DLH; pfam01738 243233005100 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 243233005101 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 243233005102 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 243233005103 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 243233005104 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243233005105 Ligand Binding Site [chemical binding]; other site 243233005106 TilS substrate binding domain; Region: TilS; pfam09179 243233005107 TilS substrate C-terminal domain; Region: TilS_C; smart00977 243233005108 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 243233005109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243233005110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243233005111 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 243233005112 DevC protein; Region: devC; TIGR01185 243233005113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243233005114 FtsX-like permease family; Region: FtsX; pfam02687 243233005115 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243233005116 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243233005117 Walker A/P-loop; other site 243233005118 ATP binding site [chemical binding]; other site 243233005119 Q-loop/lid; other site 243233005120 ABC transporter signature motif; other site 243233005121 Walker B; other site 243233005122 D-loop; other site 243233005123 H-loop/switch region; other site 243233005124 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233005125 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233005126 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 243233005127 putative protease; Provisional; Region: PRK15452 243233005128 Peptidase family U32; Region: Peptidase_U32; pfam01136 243233005129 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 243233005130 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 243233005131 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 243233005132 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 243233005133 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243233005134 active site residue [active] 243233005135 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243233005136 RNA binding surface [nucleotide binding]; other site 243233005137 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 243233005138 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243233005139 generic binding surface II; other site 243233005140 generic binding surface I; other site 243233005141 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243233005142 ligand binding site [chemical binding]; other site 243233005143 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 243233005144 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 243233005145 Predicted amidohydrolase [General function prediction only]; Region: COG0388 243233005146 putative active site [active] 243233005147 catalytic triad [active] 243233005148 putative dimer interface [polypeptide binding]; other site 243233005149 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243233005150 EamA-like transporter family; Region: EamA; pfam00892 243233005151 EamA-like transporter family; Region: EamA; pfam00892 243233005152 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 243233005153 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233005154 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233005155 catalytic residue [active] 243233005156 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 243233005157 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243233005158 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 243233005159 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 243233005160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005161 Walker A motif; other site 243233005162 ATP binding site [chemical binding]; other site 243233005163 Walker B motif; other site 243233005164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243233005165 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 243233005166 serine O-acetyltransferase; Region: cysE; TIGR01172 243233005167 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243233005168 trimer interface [polypeptide binding]; other site 243233005169 active site 243233005170 substrate binding site [chemical binding]; other site 243233005171 CoA binding site [chemical binding]; other site 243233005172 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 243233005173 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 243233005174 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 243233005175 active site 243233005176 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 243233005177 malate dehydrogenase; Provisional; Region: PRK13529 243233005178 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243233005179 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 243233005180 NAD(P) binding pocket [chemical binding]; other site 243233005181 acetolactate synthase; Reviewed; Region: PRK08617 243233005182 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243233005183 PYR/PP interface [polypeptide binding]; other site 243233005184 dimer interface [polypeptide binding]; other site 243233005185 TPP binding site [chemical binding]; other site 243233005186 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243233005187 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 243233005188 TPP-binding site [chemical binding]; other site 243233005189 dimer interface [polypeptide binding]; other site 243233005190 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 243233005191 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 243233005192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233005193 Walker A/P-loop; other site 243233005194 ATP binding site [chemical binding]; other site 243233005195 Q-loop/lid; other site 243233005196 ABC transporter signature motif; other site 243233005197 Walker B; other site 243233005198 D-loop; other site 243233005199 H-loop/switch region; other site 243233005200 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 243233005201 metal ion-dependent adhesion site (MIDAS); other site 243233005202 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243233005203 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 243233005204 Virulence factor SrfB; Region: SrfB; pfam07520 243233005205 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 243233005206 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 243233005207 active site 243233005208 substrate binding site [chemical binding]; other site 243233005209 metal binding site [ion binding]; metal-binding site 243233005210 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 243233005211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005212 Walker A motif; other site 243233005213 ATP binding site [chemical binding]; other site 243233005214 Walker B motif; other site 243233005215 arginine finger; other site 243233005216 Peptidase family M41; Region: Peptidase_M41; pfam01434 243233005217 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 243233005218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233005219 S-adenosylmethionine binding site [chemical binding]; other site 243233005220 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 243233005221 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243233005222 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243233005223 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243233005224 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243233005225 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243233005226 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243233005227 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 243233005228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243233005229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243233005230 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243233005231 IMP binding site; other site 243233005232 dimer interface [polypeptide binding]; other site 243233005233 interdomain contacts; other site 243233005234 partial ornithine binding site; other site 243233005235 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243233005236 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 243233005237 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243233005238 catalytic site [active] 243233005239 subunit interface [polypeptide binding]; other site 243233005240 dihydrodipicolinate reductase; Provisional; Region: PRK00048 243233005241 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243233005242 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243233005243 chaperone protein DnaJ; Provisional; Region: PRK10767 243233005244 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243233005245 HSP70 interaction site [polypeptide binding]; other site 243233005246 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 243233005247 substrate binding site [polypeptide binding]; other site 243233005248 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243233005249 Zn binding sites [ion binding]; other site 243233005250 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243233005251 dimer interface [polypeptide binding]; other site 243233005252 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243233005253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243233005254 nucleotide binding site [chemical binding]; other site 243233005255 GrpE; Region: GrpE; pfam01025 243233005256 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243233005257 dimer interface [polypeptide binding]; other site 243233005258 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243233005259 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 243233005260 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 243233005261 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 243233005262 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 243233005263 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 243233005264 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243233005265 Walker A/P-loop; other site 243233005266 ATP binding site [chemical binding]; other site 243233005267 Q-loop/lid; other site 243233005268 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243233005269 ABC transporter signature motif; other site 243233005270 Walker B; other site 243233005271 D-loop; other site 243233005272 H-loop/switch region; other site 243233005273 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 243233005274 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 243233005275 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 243233005276 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 243233005277 putative active site; other site 243233005278 catalytic triad [active] 243233005279 putative dimer interface [polypeptide binding]; other site 243233005280 H-NS histone family; Region: Histone_HNS; pfam00816 243233005281 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 243233005282 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 243233005283 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 243233005284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233005285 ATP binding site [chemical binding]; other site 243233005286 putative Mg++ binding site [ion binding]; other site 243233005287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233005288 nucleotide binding region [chemical binding]; other site 243233005289 ATP-binding site [chemical binding]; other site 243233005290 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 243233005291 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 243233005292 Lumazine binding domain; Region: Lum_binding; pfam00677 243233005293 Lumazine binding domain; Region: Lum_binding; pfam00677 243233005294 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 243233005295 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243233005296 dimer interface [polypeptide binding]; other site 243233005297 [2Fe-2S] cluster binding site [ion binding]; other site 243233005298 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 243233005299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233005300 ATP binding site [chemical binding]; other site 243233005301 putative Mg++ binding site [ion binding]; other site 243233005302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233005303 nucleotide binding region [chemical binding]; other site 243233005304 ATP-binding site [chemical binding]; other site 243233005305 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 243233005306 HRDC domain; Region: HRDC; pfam00570 243233005307 Cupin domain; Region: Cupin_2; cl17218 243233005308 RibD C-terminal domain; Region: RibD_C; cl17279 243233005309 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243233005310 ABC1 family; Region: ABC1; pfam03109 243233005311 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 243233005312 active site 243233005313 ATP binding site [chemical binding]; other site 243233005314 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 243233005315 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 243233005316 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 243233005317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 243233005318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243233005319 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 243233005320 Sodium Bile acid symporter family; Region: SBF; pfam01758 243233005321 homoserine O-succinyltransferase; Provisional; Region: PRK05368 243233005322 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 243233005323 proposed active site lysine [active] 243233005324 conserved cys residue [active] 243233005325 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243233005326 apolar tunnel; other site 243233005327 heme binding site [chemical binding]; other site 243233005328 dimerization interface [polypeptide binding]; other site 243233005329 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 243233005330 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243233005331 active site 243233005332 (T/H)XGH motif; other site 243233005333 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243233005334 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 243233005335 putative catalytic cysteine [active] 243233005336 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 243233005337 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 243233005338 acyl-activating enzyme (AAE) consensus motif; other site 243233005339 AMP binding site [chemical binding]; other site 243233005340 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243233005341 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243233005342 G3 box; other site 243233005343 Switch II region; other site 243233005344 G4 box; other site 243233005345 G5 box; other site 243233005346 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 243233005347 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 243233005348 HsdM N-terminal domain; Region: HsdM_N; pfam12161 243233005349 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243233005350 Virulence protein [General function prediction only]; Region: COG3943 243233005351 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 243233005352 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243233005353 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243233005354 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243233005355 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243233005356 PHP domain; Region: PHP; pfam02811 243233005357 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243233005358 active site 243233005359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233005360 AAA domain; Region: AAA_23; pfam13476 243233005361 Walker A/P-loop; other site 243233005362 ATP binding site [chemical binding]; other site 243233005363 AAA domain; Region: AAA_21; pfam13304 243233005364 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 243233005365 Divergent AAA domain; Region: AAA_4; pfam04326 243233005366 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 243233005367 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 243233005368 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 243233005369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233005370 ATP binding site [chemical binding]; other site 243233005371 putative Mg++ binding site [ion binding]; other site 243233005372 Protein of unknown function DUF45; Region: DUF45; pfam01863 243233005373 Transposase; Region: HTH_Tnp_1; cl17663 243233005374 putative transposase OrfB; Reviewed; Region: PHA02517 243233005375 HTH-like domain; Region: HTH_21; pfam13276 243233005376 Integrase core domain; Region: rve; pfam00665 243233005377 Integrase core domain; Region: rve_3; pfam13683 243233005378 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 243233005379 TRAM domain; Region: TRAM; cl01282 243233005380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233005381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233005382 S-adenosylmethionine binding site [chemical binding]; other site 243233005383 cysteine synthase B; Region: cysM; TIGR01138 243233005384 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243233005385 dimer interface [polypeptide binding]; other site 243233005386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233005387 catalytic residue [active] 243233005388 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243233005389 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 243233005390 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243233005391 calcium/proton exchanger (cax); Region: cax; TIGR00378 243233005392 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 243233005393 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 243233005394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233005395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233005396 motif II; other site 243233005397 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 243233005398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233005399 EcsC protein family; Region: EcsC; pfam12787 243233005400 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 243233005401 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243233005402 CHAD domain; Region: CHAD; pfam05235 243233005403 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 243233005404 HD domain; Region: HD_4; pfam13328 243233005405 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243233005406 synthetase active site [active] 243233005407 NTP binding site [chemical binding]; other site 243233005408 metal binding site [ion binding]; metal-binding site 243233005409 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243233005410 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 243233005411 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243233005412 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 243233005413 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243233005414 putative active site [active] 243233005415 catalytic site [active] 243233005416 putative metal binding site [ion binding]; other site 243233005417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243233005418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233005419 dimer interface [polypeptide binding]; other site 243233005420 conserved gate region; other site 243233005421 putative PBP binding loops; other site 243233005422 ABC-ATPase subunit interface; other site 243233005423 Low affinity iron permease; Region: Iron_permease; cl12096 243233005424 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 243233005425 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 243233005426 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 243233005427 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233005428 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243233005429 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243233005430 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243233005431 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 243233005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233005433 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243233005434 putative substrate translocation pore; other site 243233005435 enolase; Provisional; Region: eno; PRK00077 243233005436 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243233005437 dimer interface [polypeptide binding]; other site 243233005438 metal binding site [ion binding]; metal-binding site 243233005439 substrate binding pocket [chemical binding]; other site 243233005440 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233005441 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233005442 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233005443 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233005444 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233005445 HAMP domain; Region: HAMP; pfam00672 243233005446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233005447 dimer interface [polypeptide binding]; other site 243233005448 phosphorylation site [posttranslational modification] 243233005449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233005450 ATP binding site [chemical binding]; other site 243233005451 Mg2+ binding site [ion binding]; other site 243233005452 G-X-G motif; other site 243233005453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243233005454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233005455 active site 243233005456 phosphorylation site [posttranslational modification] 243233005457 intermolecular recognition site; other site 243233005458 dimerization interface [polypeptide binding]; other site 243233005459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233005460 DNA binding site [nucleotide binding] 243233005461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 243233005462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 243233005463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233005464 putative PBP binding loops; other site 243233005465 dimer interface [polypeptide binding]; other site 243233005466 ABC-ATPase subunit interface; other site 243233005467 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 243233005468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233005469 Walker A/P-loop; other site 243233005470 ATP binding site [chemical binding]; other site 243233005471 Q-loop/lid; other site 243233005472 ABC transporter signature motif; other site 243233005473 Walker B; other site 243233005474 D-loop; other site 243233005475 H-loop/switch region; other site 243233005476 TOBE domain; Region: TOBE_2; pfam08402 243233005477 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 243233005478 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243233005479 GTP binding site; other site 243233005480 Domain of unknown function DUF302; Region: DUF302; pfam03625 243233005481 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 243233005482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233005483 FeS/SAM binding site; other site 243233005484 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243233005485 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243233005486 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 243233005487 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 243233005488 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 243233005489 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 243233005490 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 243233005491 TPP-binding site [chemical binding]; other site 243233005492 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 243233005493 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 243233005494 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243233005495 E3 interaction surface; other site 243233005496 lipoyl attachment site [posttranslational modification]; other site 243233005497 e3 binding domain; Region: E3_binding; pfam02817 243233005498 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243233005499 polyphosphate kinase; Provisional; Region: PRK05443 243233005500 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243233005501 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243233005502 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 243233005503 putative domain interface [polypeptide binding]; other site 243233005504 putative active site [active] 243233005505 catalytic site [active] 243233005506 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 243233005507 putative domain interface [polypeptide binding]; other site 243233005508 putative active site [active] 243233005509 catalytic site [active] 243233005510 methionine sulfoxide reductase B; Provisional; Region: PRK00222 243233005511 SelR domain; Region: SelR; pfam01641 243233005512 Transposase domain (DUF772); Region: DUF772; pfam05598 243233005513 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233005514 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233005515 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 243233005516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243233005517 N-terminal plug; other site 243233005518 ligand-binding site [chemical binding]; other site 243233005519 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 243233005520 stringent starvation protein A; Provisional; Region: sspA; PRK09481 243233005521 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 243233005522 C-terminal domain interface [polypeptide binding]; other site 243233005523 putative GSH binding site (G-site) [chemical binding]; other site 243233005524 dimer interface [polypeptide binding]; other site 243233005525 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 243233005526 dimer interface [polypeptide binding]; other site 243233005527 N-terminal domain interface [polypeptide binding]; other site 243233005528 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 243233005529 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243233005530 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 243233005531 Qi binding site; other site 243233005532 intrachain domain interface; other site 243233005533 interchain domain interface [polypeptide binding]; other site 243233005534 heme bH binding site [chemical binding]; other site 243233005535 heme bL binding site [chemical binding]; other site 243233005536 Qo binding site; other site 243233005537 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 243233005538 interchain domain interface [polypeptide binding]; other site 243233005539 intrachain domain interface; other site 243233005540 Qi binding site; other site 243233005541 Qo binding site; other site 243233005542 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 243233005543 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 243233005544 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 243233005545 [2Fe-2S] cluster binding site [ion binding]; other site 243233005546 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243233005547 histidinol dehydrogenase; Region: hisD; TIGR00069 243233005548 NAD binding site [chemical binding]; other site 243233005549 dimerization interface [polypeptide binding]; other site 243233005550 product binding site; other site 243233005551 substrate binding site [chemical binding]; other site 243233005552 zinc binding site [ion binding]; other site 243233005553 catalytic residues [active] 243233005554 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 243233005555 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 243233005556 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 243233005557 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 243233005558 hinge; other site 243233005559 active site 243233005560 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243233005561 anti sigma factor interaction site; other site 243233005562 regulatory phosphorylation site [posttranslational modification]; other site 243233005563 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243233005564 mce related protein; Region: MCE; pfam02470 243233005565 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 243233005566 Permease; Region: Permease; cl00510 243233005567 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 243233005568 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243233005569 Walker A/P-loop; other site 243233005570 ATP binding site [chemical binding]; other site 243233005571 Q-loop/lid; other site 243233005572 ABC transporter signature motif; other site 243233005573 Walker B; other site 243233005574 D-loop; other site 243233005575 H-loop/switch region; other site 243233005576 seryl-tRNA synthetase; Provisional; Region: PRK05431 243233005577 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243233005578 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243233005579 dimer interface [polypeptide binding]; other site 243233005580 active site 243233005581 motif 1; other site 243233005582 motif 2; other site 243233005583 motif 3; other site 243233005584 CrcB-like protein; Region: CRCB; cl09114 243233005585 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 243233005586 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 243233005587 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 243233005588 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 243233005589 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243233005590 ribonuclease R; Region: RNase_R; TIGR02063 243233005591 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 243233005592 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243233005593 RNB domain; Region: RNB; pfam00773 243233005594 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 243233005595 RNA binding site [nucleotide binding]; other site 243233005596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243233005597 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 243233005598 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243233005599 GDP-binding site [chemical binding]; other site 243233005600 ACT binding site; other site 243233005601 IMP binding site; other site 243233005602 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 243233005603 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243233005604 dimer interface [polypeptide binding]; other site 243233005605 motif 1; other site 243233005606 active site 243233005607 motif 2; other site 243233005608 motif 3; other site 243233005609 FtsH protease regulator HflC; Provisional; Region: PRK11029 243233005610 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 243233005611 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 243233005612 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 243233005613 HflK protein; Region: hflK; TIGR01933 243233005614 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 243233005615 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243233005616 HflX GTPase family; Region: HflX; cd01878 243233005617 G1 box; other site 243233005618 GTP/Mg2+ binding site [chemical binding]; other site 243233005619 Switch I region; other site 243233005620 G2 box; other site 243233005621 G3 box; other site 243233005622 Switch II region; other site 243233005623 G4 box; other site 243233005624 G5 box; other site 243233005625 bacterial Hfq-like; Region: Hfq; cd01716 243233005626 hexamer interface [polypeptide binding]; other site 243233005627 Sm1 motif; other site 243233005628 RNA binding site [nucleotide binding]; other site 243233005629 Sm2 motif; other site 243233005630 beta-hexosaminidase; Provisional; Region: PRK05337 243233005631 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 243233005632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233005633 active site 243233005634 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 243233005635 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 243233005636 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 243233005637 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 243233005638 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 243233005639 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 243233005640 G1 box; other site 243233005641 putative GEF interaction site [polypeptide binding]; other site 243233005642 GTP/Mg2+ binding site [chemical binding]; other site 243233005643 Switch I region; other site 243233005644 G2 box; other site 243233005645 G3 box; other site 243233005646 Switch II region; other site 243233005647 G4 box; other site 243233005648 G5 box; other site 243233005649 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 243233005650 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 243233005651 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 243233005652 DEAD_2; Region: DEAD_2; pfam06733 243233005653 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243233005654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233005655 binding surface 243233005656 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243233005657 TPR motif; other site 243233005658 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243233005659 active site 243233005660 PilZ domain; Region: PilZ; cl01260 243233005661 DNA polymerase III subunit delta'; Validated; Region: PRK05707 243233005662 DNA polymerase III subunit delta'; Validated; Region: PRK08485 243233005663 thymidylate kinase; Validated; Region: tmk; PRK00698 243233005664 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243233005665 TMP-binding site; other site 243233005666 ATP-binding site [chemical binding]; other site 243233005667 YceG-like family; Region: YceG; pfam02618 243233005668 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 243233005669 dimerization interface [polypeptide binding]; other site 243233005670 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243233005671 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 243233005672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233005673 catalytic residue [active] 243233005674 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243233005675 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243233005676 dimer interface [polypeptide binding]; other site 243233005677 active site 243233005678 acyl carrier protein; Provisional; Region: acpP; PRK00982 243233005679 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243233005680 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 243233005681 NAD(P) binding site [chemical binding]; other site 243233005682 homotetramer interface [polypeptide binding]; other site 243233005683 homodimer interface [polypeptide binding]; other site 243233005684 active site 243233005685 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243233005686 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 243233005687 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243233005688 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243233005689 dimer interface [polypeptide binding]; other site 243233005690 active site 243233005691 CoA binding pocket [chemical binding]; other site 243233005692 putative phosphate acyltransferase; Provisional; Region: PRK05331 243233005693 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 243233005694 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 243233005695 Maf-like protein; Region: Maf; pfam02545 243233005696 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243233005697 active site 243233005698 dimer interface [polypeptide binding]; other site 243233005699 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243233005700 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243233005701 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233005702 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233005703 catalytic residue [active] 243233005704 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 243233005705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233005706 ATP-grasp domain; Region: ATP-grasp; pfam02222 243233005707 Calx-beta domain; Region: Calx-beta; cl02522 243233005708 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243233005709 Multicopper oxidase; Region: Cu-oxidase; pfam00394 243233005710 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243233005711 NlpE N-terminal domain; Region: NlpE; pfam04170 243233005712 prolyl-tRNA synthetase; Provisional; Region: PRK09194 243233005713 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 243233005714 dimer interface [polypeptide binding]; other site 243233005715 motif 1; other site 243233005716 active site 243233005717 motif 2; other site 243233005718 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 243233005719 putative deacylase active site [active] 243233005720 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243233005721 active site 243233005722 motif 3; other site 243233005723 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 243233005724 anticodon binding site; other site 243233005725 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 243233005726 active site 243233005727 HslU subunit interaction site [polypeptide binding]; other site 243233005728 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 243233005729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233005730 Walker A motif; other site 243233005731 ATP binding site [chemical binding]; other site 243233005732 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 243233005733 Walker B motif; other site 243233005734 arginine finger; other site 243233005735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243233005736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 243233005737 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243233005738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233005739 S-adenosylmethionine binding site [chemical binding]; other site 243233005740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 243233005741 SCP-2 sterol transfer family; Region: SCP2; pfam02036 243233005742 ABC1 family; Region: ABC1; cl17513 243233005743 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243233005744 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 243233005745 putative catalytic residue [active] 243233005746 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 243233005747 Phosphoglycerate kinase; Region: PGK; pfam00162 243233005748 substrate binding site [chemical binding]; other site 243233005749 hinge regions; other site 243233005750 ADP binding site [chemical binding]; other site 243233005751 catalytic site [active] 243233005752 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 243233005753 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 243233005754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243233005755 Zn2+ binding site [ion binding]; other site 243233005756 Mg2+ binding site [ion binding]; other site 243233005757 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243233005758 synthetase active site [active] 243233005759 NTP binding site [chemical binding]; other site 243233005760 metal binding site [ion binding]; metal-binding site 243233005761 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243233005762 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243233005763 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 243233005764 homotrimer interaction site [polypeptide binding]; other site 243233005765 putative active site [active] 243233005766 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 243233005767 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243233005768 ssDNA binding site; other site 243233005769 generic binding surface II; other site 243233005770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233005771 ATP binding site [chemical binding]; other site 243233005772 putative Mg++ binding site [ion binding]; other site 243233005773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233005774 nucleotide binding region [chemical binding]; other site 243233005775 ATP-binding site [chemical binding]; other site 243233005776 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 243233005777 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233005778 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233005779 catalytic residue [active] 243233005780 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 243233005781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243233005782 Methyltransferase domain; Region: Methyltransf_11; pfam08241 243233005783 GTP-binding protein YchF; Reviewed; Region: PRK09601 243233005784 YchF GTPase; Region: YchF; cd01900 243233005785 G1 box; other site 243233005786 GTP/Mg2+ binding site [chemical binding]; other site 243233005787 Switch I region; other site 243233005788 G2 box; other site 243233005789 Switch II region; other site 243233005790 G3 box; other site 243233005791 G4 box; other site 243233005792 G5 box; other site 243233005793 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243233005794 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243233005795 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 243233005796 Substrate binding site; other site 243233005797 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 243233005798 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 243233005799 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 243233005800 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243233005801 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243233005802 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243233005803 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243233005804 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 243233005805 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 243233005806 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 243233005807 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243233005808 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 243233005809 active site 243233005810 dimer interface [polypeptide binding]; other site 243233005811 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243233005812 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243233005813 active site 243233005814 FMN binding site [chemical binding]; other site 243233005815 substrate binding site [chemical binding]; other site 243233005816 3Fe-4S cluster binding site [ion binding]; other site 243233005817 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 243233005818 domain interface; other site 243233005819 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 243233005820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243233005821 Cation transport protein; Region: TrkH; cl17365 243233005822 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 243233005823 acetyl-CoA synthetase; Provisional; Region: PRK00174 243233005824 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 243233005825 active site 243233005826 CoA binding site [chemical binding]; other site 243233005827 acyl-activating enzyme (AAE) consensus motif; other site 243233005828 AMP binding site [chemical binding]; other site 243233005829 acetate binding site [chemical binding]; other site 243233005830 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243233005831 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243233005832 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243233005833 MarR family; Region: MarR_2; pfam12802 243233005834 spermidine synthase; Provisional; Region: PRK00811 243233005835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233005836 S-adenosylmethionine binding site [chemical binding]; other site 243233005837 arginine decarboxylase; Provisional; Region: PRK05354 243233005838 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 243233005839 dimer interface [polypeptide binding]; other site 243233005840 active site 243233005841 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243233005842 catalytic residues [active] 243233005843 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 243233005844 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243233005845 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 243233005846 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 243233005847 dimer interface [polypeptide binding]; other site 243233005848 motif 1; other site 243233005849 active site 243233005850 motif 2; other site 243233005851 motif 3; other site 243233005852 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 243233005853 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 243233005854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233005855 active site 243233005856 motif I; other site 243233005857 motif II; other site 243233005858 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243233005859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243233005860 putative acyl-acceptor binding pocket; other site 243233005861 hypothetical protein; Provisional; Region: PRK08960 243233005862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233005863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233005864 homodimer interface [polypeptide binding]; other site 243233005865 catalytic residue [active] 243233005866 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 243233005867 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 243233005868 Uncharacterized conserved protein [Function unknown]; Region: COG2308 243233005869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 243233005870 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 243233005871 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 243233005872 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 243233005873 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 243233005874 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243233005875 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243233005876 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 243233005877 FimV N-terminal domain; Region: FimV_core; TIGR03505 243233005878 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 243233005879 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 243233005880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 243233005881 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 243233005882 tartrate dehydrogenase; Region: TTC; TIGR02089 243233005883 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 243233005884 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243233005885 substrate binding site [chemical binding]; other site 243233005886 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 243233005887 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243233005888 substrate binding site [chemical binding]; other site 243233005889 ligand binding site [chemical binding]; other site 243233005890 adenylate kinase; Reviewed; Region: adk; PRK00279 243233005891 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243233005892 AMP-binding site [chemical binding]; other site 243233005893 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243233005894 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 243233005895 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 243233005896 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243233005897 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 243233005898 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 243233005899 PhnA protein; Region: PhnA; pfam03831 243233005900 PAS domain S-box; Region: sensory_box; TIGR00229 243233005901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233005902 putative active site [active] 243233005903 heme pocket [chemical binding]; other site 243233005904 PAS domain S-box; Region: sensory_box; TIGR00229 243233005905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233005906 putative active site [active] 243233005907 heme pocket [chemical binding]; other site 243233005908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243233005909 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 243233005910 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243233005911 Zn2+ binding site [ion binding]; other site 243233005912 Mg2+ binding site [ion binding]; other site 243233005913 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 243233005914 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243233005915 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243233005916 metal-binding site [ion binding] 243233005917 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233005918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233005919 motif II; other site 243233005920 LemA family; Region: LemA; cl00742 243233005921 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243233005922 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243233005923 N-terminal plug; other site 243233005924 ligand-binding site [chemical binding]; other site 243233005925 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 243233005926 active site 243233005927 substrate binding pocket [chemical binding]; other site 243233005928 dimer interface [polypeptide binding]; other site 243233005929 VacJ like lipoprotein; Region: VacJ; cl01073 243233005930 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 243233005931 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 243233005932 dimer interface [polypeptide binding]; other site 243233005933 catalytic site [active] 243233005934 putative active site [active] 243233005935 putative substrate binding site [chemical binding]; other site 243233005936 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 243233005937 putative GSH binding site [chemical binding]; other site 243233005938 catalytic residues [active] 243233005939 acetylornithine aminotransferase; Provisional; Region: PRK02627 243233005940 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243233005941 inhibitor-cofactor binding pocket; inhibition site 243233005942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233005943 catalytic residue [active] 243233005944 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243233005945 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243233005946 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243233005947 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 243233005948 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243233005949 acetylornithine deacetylase; Provisional; Region: PRK05111 243233005950 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 243233005951 metal binding site [ion binding]; metal-binding site 243233005952 putative dimer interface [polypeptide binding]; other site 243233005953 N-acetylglutamate synthase; Validated; Region: PRK05279 243233005954 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 243233005955 putative feedback inhibition sensing region; other site 243233005956 putative nucleotide binding site [chemical binding]; other site 243233005957 putative substrate binding site [chemical binding]; other site 243233005958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243233005959 Coenzyme A binding pocket [chemical binding]; other site 243233005960 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 243233005961 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243233005962 active site 243233005963 metal binding site [ion binding]; metal-binding site 243233005964 hexamer interface [polypeptide binding]; other site 243233005965 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 243233005966 putative active site [active] 243233005967 Ap4A binding site [chemical binding]; other site 243233005968 nudix motif; other site 243233005969 putative metal binding site [ion binding]; other site 243233005970 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 243233005971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233005972 motif II; other site 243233005973 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243233005974 CPxP motif; other site 243233005975 siroheme synthase; Provisional; Region: cysG; PRK10637 243233005976 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 243233005977 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 243233005978 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243233005979 active site 243233005980 SAM binding site [chemical binding]; other site 243233005981 homodimer interface [polypeptide binding]; other site 243233005982 Domain of unknown function (DUF329); Region: DUF329; pfam03884 243233005983 hypothetical protein; Provisional; Region: PRK05287 243233005984 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 243233005985 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243233005986 CoA-binding site [chemical binding]; other site 243233005987 ATP-binding [chemical binding]; other site 243233005988 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243233005989 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 243233005990 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243233005991 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243233005992 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243233005993 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243233005994 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243233005995 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243233005996 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243233005997 Walker A motif; other site 243233005998 ATP binding site [chemical binding]; other site 243233005999 Walker B motif; other site 243233006000 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243233006001 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243233006002 HIGH motif; other site 243233006003 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243233006004 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243233006005 active site 243233006006 KMSKS motif; other site 243233006007 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243233006008 tRNA binding surface [nucleotide binding]; other site 243233006009 anticodon binding site; other site 243233006010 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243233006011 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 243233006012 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243233006013 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243233006014 interface (dimer of trimers) [polypeptide binding]; other site 243233006015 Substrate-binding/catalytic site; other site 243233006016 Zn-binding sites [ion binding]; other site 243233006017 Predicted permeases [General function prediction only]; Region: COG0795 243233006018 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243233006019 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 243233006020 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243233006021 RDD family; Region: RDD; pfam06271 243233006022 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 243233006023 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 243233006024 acyl-activating enzyme (AAE) consensus motif; other site 243233006025 AMP binding site [chemical binding]; other site 243233006026 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 243233006027 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 243233006028 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243233006029 putative CoA binding site [chemical binding]; other site 243233006030 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243233006031 putative trimer interface [polypeptide binding]; other site 243233006032 putative CoA binding site [chemical binding]; other site 243233006033 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 243233006034 putative trimer interface [polypeptide binding]; other site 243233006035 putative CoA binding site [chemical binding]; other site 243233006036 Outer membrane efflux protein; Region: OEP; pfam02321 243233006037 Outer membrane efflux protein; Region: OEP; pfam02321 243233006038 hypothetical protein; Validated; Region: PRK07668 243233006039 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 243233006040 Transglycosylase SLT domain; Region: SLT_2; pfam13406 243233006041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233006042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233006043 catalytic residue [active] 243233006044 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243233006045 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233006046 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233006047 catalytic residue [active] 243233006048 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 243233006049 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 243233006050 active site residue [active] 243233006051 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243233006052 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243233006053 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 243233006054 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 243233006055 active site 243233006056 catalytic site [active] 243233006057 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 243233006058 active site 243233006059 catalytic site [active] 243233006060 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 243233006061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243233006062 ligand binding site [chemical binding]; other site 243233006063 flexible hinge region; other site 243233006064 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 243233006065 putative switch regulator; other site 243233006066 non-specific DNA interactions [nucleotide binding]; other site 243233006067 DNA binding site [nucleotide binding] 243233006068 sequence specific DNA binding site [nucleotide binding]; other site 243233006069 putative cAMP binding site [chemical binding]; other site 243233006070 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243233006071 inner membrane transport permease; Provisional; Region: PRK15066 243233006072 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243233006073 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243233006074 Walker A/P-loop; other site 243233006075 ATP binding site [chemical binding]; other site 243233006076 Q-loop/lid; other site 243233006077 ABC transporter signature motif; other site 243233006078 Walker B; other site 243233006079 D-loop; other site 243233006080 H-loop/switch region; other site 243233006081 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 243233006082 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 243233006083 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 243233006084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233006085 putative ADP-binding pocket [chemical binding]; other site 243233006086 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 243233006087 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243233006088 inhibitor-cofactor binding pocket; inhibition site 243233006089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233006090 catalytic residue [active] 243233006091 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233006092 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 243233006093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233006094 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 243233006095 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243233006096 active site 243233006097 dimer interface [polypeptide binding]; other site 243233006098 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243233006099 Ligand Binding Site [chemical binding]; other site 243233006100 Molecular Tunnel; other site 243233006101 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243233006102 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 243233006103 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 243233006104 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 243233006105 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233006106 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233006107 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233006108 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006109 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 243233006110 GSH binding site [chemical binding]; other site 243233006111 catalytic residues [active] 243233006112 thioredoxin 2; Provisional; Region: PRK10996 243233006113 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243233006114 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243233006115 catalytic residues [active] 243233006116 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243233006117 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243233006118 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243233006119 Membrane fusogenic activity; Region: BMFP; pfam04380 243233006120 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243233006121 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243233006122 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 243233006123 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 243233006124 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 243233006125 Part of AAA domain; Region: AAA_19; pfam13245 243233006126 Family description; Region: UvrD_C_2; pfam13538 243233006127 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 243233006128 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243233006129 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 243233006130 Uncharacterized conserved protein [Function unknown]; Region: COG1262 243233006131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243233006132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233006133 putative substrate translocation pore; other site 243233006134 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 243233006135 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 243233006136 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243233006137 DNA-binding site [nucleotide binding]; DNA binding site 243233006138 RNA-binding motif; other site 243233006139 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 243233006140 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233006141 Protein export membrane protein; Region: SecD_SecF; cl14618 243233006142 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233006143 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233006144 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006145 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243233006146 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243233006147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233006148 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243233006149 MPT binding site; other site 243233006150 trimer interface [polypeptide binding]; other site 243233006151 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243233006152 Rrf2 family protein; Region: rrf2_super; TIGR00738 243233006153 Transcriptional regulator; Region: Rrf2; cl17282 243233006154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243233006155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233006156 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 243233006157 PKD domain; Region: PKD; pfam00801 243233006158 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243233006159 active site 243233006160 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 243233006161 active site 243233006162 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 243233006163 putative active site [active] 243233006164 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 243233006165 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 243233006166 putative active site [active] 243233006167 putative PHP Thumb interface [polypeptide binding]; other site 243233006168 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243233006169 generic binding surface II; other site 243233006170 generic binding surface I; other site 243233006171 DNA Polymerase Y-family; Region: PolY_like; cd03468 243233006172 active site 243233006173 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 243233006174 DNA binding site [nucleotide binding] 243233006175 Uncharacterized conserved protein [Function unknown]; Region: COG4544 243233006176 LexA repressor; Validated; Region: PRK00215 243233006177 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243233006178 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243233006179 Catalytic site [active] 243233006180 BNR repeat-like domain; Region: BNR_2; pfam13088 243233006181 BNR repeat-like domain; Region: BNR_2; pfam13088 243233006182 CopC domain; Region: CopC; pfam04234 243233006183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243233006184 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243233006185 Walker A/P-loop; other site 243233006186 ATP binding site [chemical binding]; other site 243233006187 Q-loop/lid; other site 243233006188 ABC transporter signature motif; other site 243233006189 Walker B; other site 243233006190 D-loop; other site 243233006191 H-loop/switch region; other site 243233006192 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 243233006193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243233006194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 243233006195 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 243233006196 intersubunit interface [polypeptide binding]; other site 243233006197 hypothetical protein; Provisional; Region: PRK09272 243233006198 Transposase domain (DUF772); Region: DUF772; pfam05598 243233006199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233006200 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233006201 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243233006202 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243233006203 Cytochrome c; Region: Cytochrom_C; cl11414 243233006204 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 243233006205 Uncharacterized conserved protein [Function unknown]; Region: COG0432 243233006206 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 243233006207 Cytochrome c; Region: Cytochrom_C; cl11414 243233006208 short chain dehydrogenase; Provisional; Region: PRK05993 243233006209 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 243233006210 NADP binding site [chemical binding]; other site 243233006211 active site 243233006212 steroid binding site; other site 243233006213 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 243233006214 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 243233006215 active site 243233006216 dimer interface [polypeptide binding]; other site 243233006217 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 243233006218 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 243233006219 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243233006220 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243233006221 tol-pal system protein YbgF; Provisional; Region: PRK10803 243233006222 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 243233006223 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 243233006224 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243233006225 Ligand binding site; other site 243233006226 Putative Catalytic site; other site 243233006227 DXD motif; other site 243233006228 Predicted membrane protein [Function unknown]; Region: COG2246 243233006229 GtrA-like protein; Region: GtrA; pfam04138 243233006230 Cytochrome c; Region: Cytochrom_C; pfam00034 243233006231 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243233006232 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243233006233 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243233006234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243233006235 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243233006236 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243233006237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243233006238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243233006239 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243233006240 excinuclease ABC subunit B; Provisional; Region: PRK05298 243233006241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233006242 ATP binding site [chemical binding]; other site 243233006243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233006244 nucleotide binding region [chemical binding]; other site 243233006245 ATP-binding site [chemical binding]; other site 243233006246 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243233006247 UvrB/uvrC motif; Region: UVR; pfam02151 243233006248 aspartate aminotransferase; Provisional; Region: PRK05764 243233006249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233006250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233006251 homodimer interface [polypeptide binding]; other site 243233006252 catalytic residue [active] 243233006253 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243233006254 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 243233006255 active site 243233006256 tetramer interface; other site 243233006257 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 243233006258 ligand-binding site [chemical binding]; other site 243233006259 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 243233006260 probable active site [active] 243233006261 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243233006262 ScpA/B protein; Region: ScpA_ScpB; cl00598 243233006263 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 243233006264 Peptidase family M50; Region: Peptidase_M50; pfam02163 243233006265 active site 243233006266 putative substrate binding region [chemical binding]; other site 243233006267 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 243233006268 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243233006269 Glycoprotease family; Region: Peptidase_M22; pfam00814 243233006270 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 243233006271 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243233006272 ATP binding site [chemical binding]; other site 243233006273 substrate interface [chemical binding]; other site 243233006274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233006275 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243233006276 FeS/SAM binding site; other site 243233006277 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 243233006278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233006279 active site 243233006280 phosphorylation site [posttranslational modification] 243233006281 intermolecular recognition site; other site 243233006282 dimerization interface [polypeptide binding]; other site 243233006283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233006284 DNA binding site [nucleotide binding] 243233006285 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 243233006286 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 243233006287 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 243233006288 Ligand Binding Site [chemical binding]; other site 243233006289 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 243233006290 GAF domain; Region: GAF_3; pfam13492 243233006291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233006292 phosphorylation site [posttranslational modification] 243233006293 dimer interface [polypeptide binding]; other site 243233006294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233006295 ATP binding site [chemical binding]; other site 243233006296 Mg2+ binding site [ion binding]; other site 243233006297 G-X-G motif; other site 243233006298 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 243233006299 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243233006300 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243233006301 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243233006302 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 243233006303 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 243233006304 Potassium binding sites [ion binding]; other site 243233006305 Cesium cation binding sites [ion binding]; other site 243233006306 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 243233006307 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 243233006308 active site 243233006309 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243233006310 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 243233006311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233006312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233006313 S-adenosylmethionine binding site [chemical binding]; other site 243233006314 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 243233006315 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 243233006316 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 243233006317 haemagglutination activity domain; Region: Haemagg_act; smart00912 243233006318 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 243233006319 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 243233006320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233006321 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006322 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 243233006323 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 243233006324 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243233006325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243233006326 TonB C terminal; Region: TonB_2; pfam13103 243233006327 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 243233006328 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 243233006329 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 243233006330 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 243233006331 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 243233006332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233006333 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 243233006334 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243233006335 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243233006336 putative active site [active] 243233006337 putative metal binding site [ion binding]; other site 243233006338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233006339 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 243233006340 NAD(P) binding site [chemical binding]; other site 243233006341 active site 243233006342 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 243233006343 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243233006344 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243233006345 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 243233006346 GTP1/OBG; Region: GTP1_OBG; pfam01018 243233006347 Obg GTPase; Region: Obg; cd01898 243233006348 G1 box; other site 243233006349 GTP/Mg2+ binding site [chemical binding]; other site 243233006350 Switch I region; other site 243233006351 G2 box; other site 243233006352 G3 box; other site 243233006353 Switch II region; other site 243233006354 G4 box; other site 243233006355 G5 box; other site 243233006356 gamma-glutamyl kinase; Provisional; Region: PRK05429 243233006357 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243233006358 nucleotide binding site [chemical binding]; other site 243233006359 homotetrameric interface [polypeptide binding]; other site 243233006360 putative phosphate binding site [ion binding]; other site 243233006361 putative allosteric binding site; other site 243233006362 PUA domain; Region: PUA; pfam01472 243233006363 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243233006364 integral membrane protein MviN; Region: mviN; TIGR01695 243233006365 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 243233006366 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243233006367 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243233006368 active site 243233006369 Riboflavin kinase; Region: Flavokinase; smart00904 243233006370 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243233006371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243233006372 active site 243233006373 HIGH motif; other site 243233006374 nucleotide binding site [chemical binding]; other site 243233006375 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243233006376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243233006377 active site 243233006378 KMSKS motif; other site 243233006379 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243233006380 tRNA binding surface [nucleotide binding]; other site 243233006381 anticodon binding site; other site 243233006382 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243233006383 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 243233006384 lipoprotein signal peptidase; Provisional; Region: PRK14787 243233006385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243233006386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243233006387 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 243233006388 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 243233006389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233006390 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233006392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243233006393 putative substrate translocation pore; other site 243233006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233006395 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 243233006396 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 243233006397 THF binding site; other site 243233006398 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 243233006399 substrate binding site [chemical binding]; other site 243233006400 THF binding site; other site 243233006401 zinc-binding site [ion binding]; other site 243233006402 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 243233006403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233006404 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 243233006405 putative dimerization interface [polypeptide binding]; other site 243233006406 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233006407 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243233006408 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006409 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233006410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 243233006411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243233006412 putative metal binding site [ion binding]; other site 243233006413 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 243233006414 putative FMN binding site [chemical binding]; other site 243233006415 Pirin-related protein [General function prediction only]; Region: COG1741 243233006416 Pirin; Region: Pirin; pfam02678 243233006417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243233006418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233006419 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 243233006420 putative dimerization interface [polypeptide binding]; other site 243233006421 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 243233006422 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243233006423 PYR/PP interface [polypeptide binding]; other site 243233006424 dimer interface [polypeptide binding]; other site 243233006425 TPP binding site [chemical binding]; other site 243233006426 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243233006427 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 243233006428 TPP-binding site [chemical binding]; other site 243233006429 dimer interface [polypeptide binding]; other site 243233006430 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243233006431 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243233006432 putative valine binding site [chemical binding]; other site 243233006433 dimer interface [polypeptide binding]; other site 243233006434 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243233006435 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243233006436 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243233006437 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243233006438 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243233006439 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 243233006440 2-isopropylmalate synthase; Validated; Region: PRK00915 243233006441 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 243233006442 active site 243233006443 catalytic residues [active] 243233006444 metal binding site [ion binding]; metal-binding site 243233006445 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243233006446 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243233006447 Fe-S cluster binding site [ion binding]; other site 243233006448 active site 243233006449 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243233006450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243233006451 Coenzyme A binding pocket [chemical binding]; other site 243233006452 two-component sensor protein; Provisional; Region: cpxA; PRK09470 243233006453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233006454 dimerization interface [polypeptide binding]; other site 243233006455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233006456 dimer interface [polypeptide binding]; other site 243233006457 phosphorylation site [posttranslational modification] 243233006458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233006459 ATP binding site [chemical binding]; other site 243233006460 Mg2+ binding site [ion binding]; other site 243233006461 G-X-G motif; other site 243233006462 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 243233006463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233006464 active site 243233006465 phosphorylation site [posttranslational modification] 243233006466 intermolecular recognition site; other site 243233006467 dimerization interface [polypeptide binding]; other site 243233006468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233006469 DNA binding site [nucleotide binding] 243233006470 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 243233006471 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 243233006472 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243233006473 putative active site [active] 243233006474 putative dimer interface [polypeptide binding]; other site 243233006475 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 243233006476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243233006477 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 243233006478 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 243233006479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233006480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233006481 homodimer interface [polypeptide binding]; other site 243233006482 catalytic residue [active] 243233006483 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 243233006484 putative FMN binding site [chemical binding]; other site 243233006485 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 243233006486 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243233006487 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 243233006488 catalytic triad [active] 243233006489 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 243233006490 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 243233006491 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243233006492 dimer interface [polypeptide binding]; other site 243233006493 [2Fe-2S] cluster binding site [ion binding]; other site 243233006494 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 243233006495 active site 243233006496 SAM binding site [chemical binding]; other site 243233006497 homodimer interface [polypeptide binding]; other site 243233006498 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 243233006499 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 243233006500 active site 243233006501 SAM binding site [chemical binding]; other site 243233006502 homodimer interface [polypeptide binding]; other site 243233006503 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 243233006504 active site 243233006505 putative homodimer interface [polypeptide binding]; other site 243233006506 SAM binding site [chemical binding]; other site 243233006507 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 243233006508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233006509 S-adenosylmethionine binding site [chemical binding]; other site 243233006510 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 243233006511 Precorrin-8X methylmutase; Region: CbiC; pfam02570 243233006512 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 243233006513 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 243233006514 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243233006515 putative active site [active] 243233006516 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 243233006517 putative active site [active] 243233006518 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 243233006519 active site 243233006520 SAM binding site [chemical binding]; other site 243233006521 homodimer interface [polypeptide binding]; other site 243233006522 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 243233006523 cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459 243233006524 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 243233006525 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243233006526 cobyric acid synthase; Provisional; Region: PRK00784 243233006527 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243233006528 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 243233006529 catalytic triad [active] 243233006530 conserved hypothetical protein; Region: MG423; TIGR00649 243233006531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 243233006532 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243233006533 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 243233006534 Histidine carboxylase PI chain; Region: HDC; cl03540 243233006535 Pirin; Region: Pirin; pfam02678 243233006536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233006537 S-adenosylmethionine binding site [chemical binding]; other site 243233006538 poly(A) polymerase; Region: pcnB; TIGR01942 243233006539 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243233006540 active site 243233006541 NTP binding site [chemical binding]; other site 243233006542 metal binding triad [ion binding]; metal-binding site 243233006543 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243233006544 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 243233006545 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243233006546 catalytic center binding site [active] 243233006547 ATP binding site [chemical binding]; other site 243233006548 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243233006549 oligomerization interface [polypeptide binding]; other site 243233006550 active site 243233006551 metal binding site [ion binding]; metal-binding site 243233006552 pantoate--beta-alanine ligase; Region: panC; TIGR00018 243233006553 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243233006554 active site 243233006555 ATP-binding site [chemical binding]; other site 243233006556 pantoate-binding site; other site 243233006557 HXXH motif; other site 243233006558 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 243233006559 tetramerization interface [polypeptide binding]; other site 243233006560 active site 243233006561 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243233006562 dihydropteroate synthase; Region: DHPS; TIGR01496 243233006563 substrate binding pocket [chemical binding]; other site 243233006564 dimer interface [polypeptide binding]; other site 243233006565 inhibitor binding site; inhibition site 243233006566 putative GTP cyclohydrolase; Provisional; Region: PRK13674 243233006567 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 243233006568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243233006569 active site 243233006570 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 243233006571 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 243233006572 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243233006573 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243233006574 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243233006575 metal binding site 2 [ion binding]; metal-binding site 243233006576 putative DNA binding helix; other site 243233006577 metal binding site 1 [ion binding]; metal-binding site 243233006578 dimer interface [polypeptide binding]; other site 243233006579 structural Zn2+ binding site [ion binding]; other site 243233006580 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233006581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233006582 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233006583 Outer membrane efflux protein; Region: OEP; pfam02321 243233006584 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 243233006585 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 243233006586 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233006587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243233006588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233006589 active site 243233006590 phosphorylation site [posttranslational modification] 243233006591 intermolecular recognition site; other site 243233006592 dimerization interface [polypeptide binding]; other site 243233006593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233006594 DNA binding site [nucleotide binding] 243233006595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233006596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233006597 dimerization interface [polypeptide binding]; other site 243233006598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233006599 dimer interface [polypeptide binding]; other site 243233006600 phosphorylation site [posttranslational modification] 243233006601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233006602 ATP binding site [chemical binding]; other site 243233006603 Mg2+ binding site [ion binding]; other site 243233006604 G-X-G motif; other site 243233006605 dihydroorotase; Provisional; Region: PRK07627 243233006606 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243233006607 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243233006608 active site 243233006609 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243233006610 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243233006611 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243233006612 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233006613 active site 243233006614 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 243233006615 hypothetical protein; Validated; Region: PRK00228 243233006616 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243233006617 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 243233006618 glutathione synthetase; Provisional; Region: PRK05246 243233006619 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 243233006620 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 243233006621 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243233006622 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 243233006623 ParA-like protein; Provisional; Region: PHA02518 243233006624 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243233006625 P-loop; other site 243233006626 Magnesium ion binding site [ion binding]; other site 243233006627 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243233006628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243233006629 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233006630 protein binding site [polypeptide binding]; other site 243233006631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243233006632 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 243233006633 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 243233006634 homodimer interface [polypeptide binding]; other site 243233006635 substrate-cofactor binding pocket; other site 243233006636 catalytic residue [active] 243233006637 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 243233006638 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243233006639 metal binding triad; other site 243233006640 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243233006641 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243233006642 metal binding triad; other site 243233006643 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243233006644 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 243233006645 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243233006646 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243233006647 alphaNTD homodimer interface [polypeptide binding]; other site 243233006648 alphaNTD - beta interaction site [polypeptide binding]; other site 243233006649 alphaNTD - beta' interaction site [polypeptide binding]; other site 243233006650 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243233006651 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243233006652 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243233006653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243233006654 RNA binding surface [nucleotide binding]; other site 243233006655 30S ribosomal protein S11; Validated; Region: PRK05309 243233006656 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243233006657 30S ribosomal protein S13; Region: bact_S13; TIGR03631 243233006658 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 243233006659 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243233006660 SecY translocase; Region: SecY; pfam00344 243233006661 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243233006662 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 243233006663 23S rRNA binding site [nucleotide binding]; other site 243233006664 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243233006665 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243233006666 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243233006667 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243233006668 5S rRNA interface [nucleotide binding]; other site 243233006669 23S rRNA interface [nucleotide binding]; other site 243233006670 L5 interface [polypeptide binding]; other site 243233006671 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243233006672 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243233006673 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243233006674 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243233006675 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 243233006676 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243233006677 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243233006678 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243233006679 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 243233006680 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243233006681 RNA binding site [nucleotide binding]; other site 243233006682 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243233006683 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243233006684 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243233006685 23S rRNA interface [nucleotide binding]; other site 243233006686 putative translocon interaction site; other site 243233006687 signal recognition particle (SRP54) interaction site; other site 243233006688 L23 interface [polypeptide binding]; other site 243233006689 trigger factor interaction site; other site 243233006690 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243233006691 23S rRNA interface [nucleotide binding]; other site 243233006692 5S rRNA interface [nucleotide binding]; other site 243233006693 putative antibiotic binding site [chemical binding]; other site 243233006694 L25 interface [polypeptide binding]; other site 243233006695 L27 interface [polypeptide binding]; other site 243233006696 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 243233006697 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243233006698 G-X-X-G motif; other site 243233006699 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243233006700 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243233006701 putative translocon binding site; other site 243233006702 protein-rRNA interface [nucleotide binding]; other site 243233006703 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243233006704 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243233006705 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243233006706 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243233006707 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243233006708 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 243233006709 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 243233006710 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243233006711 elongation factor Tu; Reviewed; Region: PRK00049 243233006712 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243233006713 G1 box; other site 243233006714 GEF interaction site [polypeptide binding]; other site 243233006715 GTP/Mg2+ binding site [chemical binding]; other site 243233006716 Switch I region; other site 243233006717 G2 box; other site 243233006718 G3 box; other site 243233006719 Switch II region; other site 243233006720 G4 box; other site 243233006721 G5 box; other site 243233006722 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243233006723 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243233006724 Antibiotic Binding Site [chemical binding]; other site 243233006725 elongation factor G; Reviewed; Region: PRK00007 243233006726 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243233006727 G1 box; other site 243233006728 putative GEF interaction site [polypeptide binding]; other site 243233006729 GTP/Mg2+ binding site [chemical binding]; other site 243233006730 Switch I region; other site 243233006731 G2 box; other site 243233006732 G3 box; other site 243233006733 Switch II region; other site 243233006734 G4 box; other site 243233006735 G5 box; other site 243233006736 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243233006737 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243233006738 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243233006739 30S ribosomal protein S7; Validated; Region: PRK05302 243233006740 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243233006741 S17 interaction site [polypeptide binding]; other site 243233006742 S8 interaction site; other site 243233006743 16S rRNA interaction site [nucleotide binding]; other site 243233006744 streptomycin interaction site [chemical binding]; other site 243233006745 23S rRNA interaction site [nucleotide binding]; other site 243233006746 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243233006747 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 243233006748 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 243233006749 catalytic site [active] 243233006750 putative active site [active] 243233006751 putative substrate binding site [chemical binding]; other site 243233006752 HRDC domain; Region: HRDC; pfam00570 243233006753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 243233006754 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 243233006755 AAA domain; Region: AAA_33; pfam13671 243233006756 ATP-binding site [chemical binding]; other site 243233006757 Gluconate-6-phosphate binding site [chemical binding]; other site 243233006758 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233006759 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233006760 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233006761 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243233006762 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 243233006763 putative hydrophobic ligand binding site [chemical binding]; other site 243233006764 protein interface [polypeptide binding]; other site 243233006765 gate; other site 243233006766 exonuclease I; Provisional; Region: sbcB; PRK11779 243233006767 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 243233006768 active site 243233006769 catalytic site [active] 243233006770 substrate binding site [chemical binding]; other site 243233006771 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 243233006772 Protein of unknown function (DUF539); Region: DUF539; cl01129 243233006773 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 243233006774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233006775 catalytic loop [active] 243233006776 iron binding site [ion binding]; other site 243233006777 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 243233006778 FAD binding pocket [chemical binding]; other site 243233006779 FAD binding motif [chemical binding]; other site 243233006780 phosphate binding motif [ion binding]; other site 243233006781 beta-alpha-beta structure motif; other site 243233006782 NAD binding pocket [chemical binding]; other site 243233006783 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 243233006784 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 243233006785 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 243233006786 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 243233006787 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 243233006788 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 243233006789 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 243233006790 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 243233006791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233006792 FeS/SAM binding site; other site 243233006793 Cytochrome c; Region: Cytochrom_C; cl11414 243233006794 Cytochrome c; Region: Cytochrom_C; cl11414 243233006795 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 243233006796 Putative D-pathway homolog; other site 243233006797 Low-spin heme binding site [chemical binding]; other site 243233006798 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 243233006799 Subunit I/II interface [polypeptide binding]; other site 243233006800 Putative Q-pathway; other site 243233006801 Putative alternate electron transfer pathway; other site 243233006802 Putative water exit pathway; other site 243233006803 Binuclear center (active site) [active] 243233006804 Putative K-pathway homolog; other site 243233006805 Putative proton exit pathway; other site 243233006806 Subunit I/IIa interface [polypeptide binding]; other site 243233006807 Electron transfer pathway; other site 243233006808 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 243233006809 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 243233006810 Cytochrome c; Region: Cytochrom_C; pfam00034 243233006811 HPP family; Region: HPP; pfam04982 243233006812 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243233006813 FOG: CBS domain [General function prediction only]; Region: COG0517 243233006814 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 243233006815 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243233006816 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243233006817 catalytic residue [active] 243233006818 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243233006819 Cytochrome c; Region: Cytochrom_C; cl11414 243233006820 Protein of unknown function (DUF423); Region: DUF423; pfam04241 243233006821 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243233006822 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233006823 catalytic residues [active] 243233006824 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 243233006825 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 243233006826 ApbE family; Region: ApbE; pfam02424 243233006827 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 243233006828 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 243233006829 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 243233006830 putative active site [active] 243233006831 putative dimer interface [polypeptide binding]; other site 243233006832 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 243233006833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233006834 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243233006835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233006836 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243233006837 putative ADP-binding pocket [chemical binding]; other site 243233006838 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243233006839 Predicted membrane protein [Function unknown]; Region: COG2119 243233006840 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243233006841 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 243233006842 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243233006843 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 243233006844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233006845 S-adenosylmethionine binding site [chemical binding]; other site 243233006846 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 243233006847 CoA binding domain; Region: CoA_binding_2; pfam13380 243233006848 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 243233006849 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 243233006850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 243233006851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243233006852 Coenzyme A binding pocket [chemical binding]; other site 243233006853 Protein of unknown function (DUF721); Region: DUF721; pfam05258 243233006854 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 243233006855 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243233006856 cell division protein FtsZ; Validated; Region: PRK09330 243233006857 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243233006858 nucleotide binding site [chemical binding]; other site 243233006859 SulA interaction site; other site 243233006860 cell division protein FtsA; Region: ftsA; TIGR01174 243233006861 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243233006862 nucleotide binding site [chemical binding]; other site 243233006863 Cell division protein FtsA; Region: FtsA; pfam14450 243233006864 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 243233006865 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 243233006866 Cell division protein FtsQ; Region: FtsQ; pfam03799 243233006867 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 243233006868 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 243233006869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243233006870 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 243233006871 FAD binding domain; Region: FAD_binding_4; pfam01565 243233006872 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243233006873 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 243233006874 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243233006875 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233006876 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233006877 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 243233006878 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 243233006879 active site 243233006880 homodimer interface [polypeptide binding]; other site 243233006881 cell division protein FtsW; Region: ftsW; TIGR02614 243233006882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 243233006883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233006884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233006885 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 243233006886 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 243233006887 Mg++ binding site [ion binding]; other site 243233006888 putative catalytic motif [active] 243233006889 putative substrate binding site [chemical binding]; other site 243233006890 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 243233006891 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243233006892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233006893 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233006894 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243233006895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 243233006896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243233006897 Cell division protein FtsL; Region: FtsL; pfam04999 243233006898 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 243233006899 MraW methylase family; Region: Methyltransf_5; cl17771 243233006900 cell division protein MraZ; Reviewed; Region: PRK00326 243233006901 MraZ protein; Region: MraZ; pfam02381 243233006902 MraZ protein; Region: MraZ; pfam02381 243233006903 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243233006904 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243233006905 nucleotide binding pocket [chemical binding]; other site 243233006906 K-X-D-G motif; other site 243233006907 catalytic site [active] 243233006908 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243233006909 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243233006910 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243233006911 Dimer interface [polypeptide binding]; other site 243233006912 BRCT sequence motif; other site 243233006913 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 243233006914 FtsZ protein binding site [polypeptide binding]; other site 243233006915 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243233006916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233006917 Q-loop/lid; other site 243233006918 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 243233006919 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243233006920 Q-loop/lid; other site 243233006921 ABC transporter signature motif; other site 243233006922 Walker B; other site 243233006923 D-loop; other site 243233006924 H-loop/switch region; other site 243233006925 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 243233006926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 243233006927 MOSC domain; Region: MOSC; pfam03473 243233006928 3-alpha domain; Region: 3-alpha; pfam03475 243233006929 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 243233006930 RNA/DNA hybrid binding site [nucleotide binding]; other site 243233006931 active site 243233006932 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243233006933 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243233006934 active site 243233006935 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243233006936 periplasmic chaperone; Provisional; Region: PRK10780 243233006937 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 243233006938 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 243233006939 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243233006940 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243233006941 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243233006942 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243233006943 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243233006944 Surface antigen; Region: Bac_surface_Ag; pfam01103 243233006945 transcriptional regulator PhoU; Provisional; Region: PRK11115 243233006946 PhoU domain; Region: PhoU; pfam01895 243233006947 PhoU domain; Region: PhoU; pfam01895 243233006948 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243233006949 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 243233006950 putative NAD(P) binding site [chemical binding]; other site 243233006951 active site 243233006952 putative substrate binding site [chemical binding]; other site 243233006953 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 243233006954 Walker A motif; other site 243233006955 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 243233006956 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243233006957 NAD binding site [chemical binding]; other site 243233006958 homodimer interface [polypeptide binding]; other site 243233006959 active site 243233006960 substrate binding site [chemical binding]; other site 243233006961 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 243233006962 hydrophobic ligand binding site; other site 243233006963 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 243233006964 putative active site [active] 243233006965 putative metal binding residues [ion binding]; other site 243233006966 signature motif; other site 243233006967 putative dimer interface [polypeptide binding]; other site 243233006968 putative phosphate binding site [ion binding]; other site 243233006969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243233006970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233006971 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 243233006972 putative effector binding pocket; other site 243233006973 dimerization interface [polypeptide binding]; other site 243233006974 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 243233006975 SnoaL-like domain; Region: SnoaL_3; pfam13474 243233006976 superoxide dismutase; Provisional; Region: PRK10543 243233006977 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 243233006978 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243233006979 C factor cell-cell signaling protein; Provisional; Region: PRK09009 243233006980 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 243233006981 NADP binding site [chemical binding]; other site 243233006982 homodimer interface [polypeptide binding]; other site 243233006983 active site 243233006984 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 243233006985 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 243233006986 putative active site pocket [active] 243233006987 dimerization interface [polypeptide binding]; other site 243233006988 putative catalytic residue [active] 243233006989 lysophospholipid transporter LplT; Provisional; Region: PRK11195 243233006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233006991 putative substrate translocation pore; other site 243233006992 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 243233006993 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 243233006994 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243233006995 Active Sites [active] 243233006996 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 243233006997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233006998 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 243233006999 substrate binding site [chemical binding]; other site 243233007000 dimerization interface [polypeptide binding]; other site 243233007001 Ferredoxin [Energy production and conversion]; Region: COG1146 243233007002 4Fe-4S binding domain; Region: Fer4; cl02805 243233007003 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 243233007004 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243233007005 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 243233007006 active site 243233007007 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243233007008 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 243233007009 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243233007010 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 243233007011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233007012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233007013 dimer interface [polypeptide binding]; other site 243233007014 phosphorylation site [posttranslational modification] 243233007015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233007016 ATP binding site [chemical binding]; other site 243233007017 Mg2+ binding site [ion binding]; other site 243233007018 G-X-G motif; other site 243233007019 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243233007020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233007021 active site 243233007022 phosphorylation site [posttranslational modification] 243233007023 intermolecular recognition site; other site 243233007024 dimerization interface [polypeptide binding]; other site 243233007025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233007026 Walker A motif; other site 243233007027 ATP binding site [chemical binding]; other site 243233007028 Walker B motif; other site 243233007029 arginine finger; other site 243233007030 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233007031 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243233007032 active site 243233007033 dimerization interface [polypeptide binding]; other site 243233007034 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 243233007035 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 243233007036 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 243233007037 catalytic residues [active] 243233007038 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 243233007039 oxaloacetate decarboxylase; Provisional; Region: PRK14040 243233007040 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 243233007041 active site 243233007042 catalytic residues [active] 243233007043 metal binding site [ion binding]; metal-binding site 243233007044 homodimer binding site [polypeptide binding]; other site 243233007045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243233007046 carboxyltransferase (CT) interaction site; other site 243233007047 biotinylation site [posttranslational modification]; other site 243233007048 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 243233007049 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 243233007050 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243233007051 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 243233007052 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 243233007053 dinuclear metal binding motif [ion binding]; other site 243233007054 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 243233007055 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 243233007056 substrate binding site [chemical binding]; other site 243233007057 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 243233007058 substrate binding site [chemical binding]; other site 243233007059 ligand binding site [chemical binding]; other site 243233007060 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 243233007061 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 243233007062 putative active site [active] 243233007063 Zn binding site [ion binding]; other site 243233007064 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243233007065 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243233007066 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243233007067 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243233007068 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 243233007069 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243233007070 homodimer interface [polypeptide binding]; other site 243233007071 substrate-cofactor binding pocket; other site 243233007072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233007073 catalytic residue [active] 243233007074 amidophosphoribosyltransferase; Provisional; Region: PRK09246 243233007075 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 243233007076 active site 243233007077 tetramer interface [polypeptide binding]; other site 243233007078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233007079 active site 243233007080 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 243233007081 Colicin V production protein; Region: Colicin_V; cl00567 243233007082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 243233007083 Sporulation related domain; Region: SPOR; pfam05036 243233007084 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243233007085 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243233007086 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243233007087 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 243233007088 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 243233007089 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 243233007090 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 243233007091 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243233007092 substrate binding site [chemical binding]; other site 243233007093 active site 243233007094 catalytic residues [active] 243233007095 heterodimer interface [polypeptide binding]; other site 243233007096 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 243233007097 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243233007098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233007099 catalytic residue [active] 243233007100 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 243233007101 active site 243233007102 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243233007103 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243233007104 dimerization interface 3.5A [polypeptide binding]; other site 243233007105 active site 243233007106 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 243233007107 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 243233007108 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 243233007109 Transcriptional regulator; Region: Rrf2; cl17282 243233007110 Rrf2 family protein; Region: rrf2_super; TIGR00738 243233007111 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 243233007112 apolar tunnel; other site 243233007113 heme binding site [chemical binding]; other site 243233007114 dimerization interface [polypeptide binding]; other site 243233007115 hypothetical protein; Provisional; Region: PRK05713 243233007116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233007117 catalytic loop [active] 243233007118 iron binding site [ion binding]; other site 243233007119 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 243233007120 FAD binding pocket [chemical binding]; other site 243233007121 FAD binding motif [chemical binding]; other site 243233007122 phosphate binding motif [ion binding]; other site 243233007123 beta-alpha-beta structure motif; other site 243233007124 NAD binding pocket [chemical binding]; other site 243233007125 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 243233007126 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 243233007127 Cl- selectivity filter; other site 243233007128 Cl- binding residues [ion binding]; other site 243233007129 pore gating glutamate residue; other site 243233007130 dimer interface [polypeptide binding]; other site 243233007131 H+/Cl- coupling transport residue; other site 243233007132 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 243233007133 Transposase domain (DUF772); Region: DUF772; pfam05598 243233007134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233007135 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233007136 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 243233007137 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 243233007138 CTP synthetase; Validated; Region: pyrG; PRK05380 243233007139 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243233007140 Catalytic site [active] 243233007141 active site 243233007142 UTP binding site [chemical binding]; other site 243233007143 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243233007144 active site 243233007145 putative oxyanion hole; other site 243233007146 catalytic triad [active] 243233007147 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 243233007148 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 243233007149 enolase; Provisional; Region: eno; PRK00077 243233007150 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243233007151 dimer interface [polypeptide binding]; other site 243233007152 metal binding site [ion binding]; metal-binding site 243233007153 substrate binding pocket [chemical binding]; other site 243233007154 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 243233007155 Septum formation initiator; Region: DivIC; cl17659 243233007156 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243233007157 substrate binding site; other site 243233007158 dimer interface; other site 243233007159 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243233007160 homotrimer interaction site [polypeptide binding]; other site 243233007161 zinc binding site [ion binding]; other site 243233007162 CDP-binding sites; other site 243233007163 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 243233007164 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 243233007165 Permutation of conserved domain; other site 243233007166 active site 243233007167 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 243233007168 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 243233007169 ArsC family; Region: ArsC; pfam03960 243233007170 catalytic residues [active] 243233007171 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 243233007172 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243233007173 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 243233007174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233007175 Walker A motif; other site 243233007176 ATP binding site [chemical binding]; other site 243233007177 Walker B motif; other site 243233007178 arginine finger; other site 243233007179 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 243233007180 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243233007181 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243233007182 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 243233007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243233007184 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 243233007185 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 243233007186 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243233007187 active site 243233007188 HIGH motif; other site 243233007189 dimer interface [polypeptide binding]; other site 243233007190 KMSKS motif; other site 243233007191 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 243233007192 active site 243233007193 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 243233007194 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 243233007195 XdhC Rossmann domain; Region: XdhC_C; pfam13478 243233007196 ATP-grasp domain; Region: ATP-grasp; pfam02222 243233007197 AIR carboxylase; Region: AIRC; pfam00731 243233007198 ATP-dependent helicase HepA; Validated; Region: PRK04914 243233007199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233007200 ATP binding site [chemical binding]; other site 243233007201 putative Mg++ binding site [ion binding]; other site 243233007202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233007203 nucleotide binding region [chemical binding]; other site 243233007204 ATP-binding site [chemical binding]; other site 243233007205 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243233007206 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243233007207 putative dimer interface [polypeptide binding]; other site 243233007208 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 243233007209 C-terminal peptidase (prc); Region: prc; TIGR00225 243233007210 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243233007211 protein binding site [polypeptide binding]; other site 243233007212 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243233007213 Catalytic dyad [active] 243233007214 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 243233007215 Peptidase family M23; Region: Peptidase_M23; pfam01551 243233007216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243233007217 dimerization interface [polypeptide binding]; other site 243233007218 putative DNA binding site [nucleotide binding]; other site 243233007219 putative Zn2+ binding site [ion binding]; other site 243233007220 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243233007221 active site residue [active] 243233007222 preprotein translocase subunit SecB; Validated; Region: PRK05751 243233007223 SecA binding site; other site 243233007224 Preprotein binding site; other site 243233007225 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 243233007226 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 243233007227 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 243233007228 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243233007229 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 243233007230 homodimer interface [polypeptide binding]; other site 243233007231 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 243233007232 active site pocket [active] 243233007233 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 243233007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233007235 active site 243233007236 phosphorylation site [posttranslational modification] 243233007237 intermolecular recognition site; other site 243233007238 dimerization interface [polypeptide binding]; other site 243233007239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233007240 Walker A motif; other site 243233007241 ATP binding site [chemical binding]; other site 243233007242 Walker B motif; other site 243233007243 arginine finger; other site 243233007244 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233007245 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243233007246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233007247 dimer interface [polypeptide binding]; other site 243233007248 phosphorylation site [posttranslational modification] 243233007249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233007250 ATP binding site [chemical binding]; other site 243233007251 Mg2+ binding site [ion binding]; other site 243233007252 G-X-G motif; other site 243233007253 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 243233007254 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 243233007255 active site 243233007256 dimer interface [polypeptide binding]; other site 243233007257 effector binding site; other site 243233007258 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 243233007259 protein-splicing catalytic site; other site 243233007260 thioester formation/cholesterol transfer; other site 243233007261 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 243233007262 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 243233007263 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 243233007264 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 243233007265 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233007266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007267 S-adenosylmethionine binding site [chemical binding]; other site 243233007268 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243233007269 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243233007270 putative ADP-binding pocket [chemical binding]; other site 243233007271 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 243233007272 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243233007273 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243233007274 Walker A/P-loop; other site 243233007275 ATP binding site [chemical binding]; other site 243233007276 Q-loop/lid; other site 243233007277 ABC transporter signature motif; other site 243233007278 Walker B; other site 243233007279 D-loop; other site 243233007280 H-loop/switch region; other site 243233007281 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 243233007282 putative carbohydrate binding site [chemical binding]; other site 243233007283 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243233007284 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 243233007285 Family description; Region: VCBS; pfam13517 243233007286 Transposase domain (DUF772); Region: DUF772; pfam05598 243233007287 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233007288 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233007289 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 243233007290 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233007291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233007292 active site 243233007293 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243233007294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243233007295 active site 243233007296 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 243233007297 putative ligand binding site [chemical binding]; other site 243233007298 putative catalytic site [active] 243233007299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233007300 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 243233007301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243233007302 Methyltransferase domain; Region: Methyltransf_11; pfam08241 243233007303 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 243233007304 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 243233007305 FAD binding domain; Region: FAD_binding_4; pfam01565 243233007306 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 243233007307 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 243233007308 classical (c) SDRs; Region: SDR_c; cd05233 243233007309 NAD(P) binding site [chemical binding]; other site 243233007310 active site 243233007311 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 243233007312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233007313 FeS/SAM binding site; other site 243233007314 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 243233007315 GIY-YIG motif/motif A; other site 243233007316 putative active site [active] 243233007317 putative metal binding site [ion binding]; other site 243233007318 DNA polymerase I; Provisional; Region: PRK05755 243233007319 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243233007320 active site 243233007321 metal binding site 1 [ion binding]; metal-binding site 243233007322 putative 5' ssDNA interaction site; other site 243233007323 metal binding site 3; metal-binding site 243233007324 metal binding site 2 [ion binding]; metal-binding site 243233007325 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243233007326 putative DNA binding site [nucleotide binding]; other site 243233007327 putative metal binding site [ion binding]; other site 243233007328 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 243233007329 active site 243233007330 catalytic site [active] 243233007331 substrate binding site [chemical binding]; other site 243233007332 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243233007333 active site 243233007334 DNA binding site [nucleotide binding] 243233007335 catalytic site [active] 243233007336 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 243233007337 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 243233007338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233007339 catalytic loop [active] 243233007340 iron binding site [ion binding]; other site 243233007341 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 243233007342 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243233007343 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 243233007344 [4Fe-4S] binding site [ion binding]; other site 243233007345 molybdopterin cofactor binding site; other site 243233007346 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 243233007347 molybdopterin cofactor binding site; other site 243233007348 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 243233007349 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 243233007350 putative dimer interface [polypeptide binding]; other site 243233007351 [2Fe-2S] cluster binding site [ion binding]; other site 243233007352 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 243233007353 SLBB domain; Region: SLBB; pfam10531 243233007354 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 243233007355 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 243233007356 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 243233007357 Walker A/P-loop; other site 243233007358 ATP binding site [chemical binding]; other site 243233007359 Q-loop/lid; other site 243233007360 ABC transporter signature motif; other site 243233007361 Walker B; other site 243233007362 D-loop; other site 243233007363 H-loop/switch region; other site 243233007364 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243233007365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243233007366 dimer interface [polypeptide binding]; other site 243233007367 conserved gate region; other site 243233007368 putative PBP binding loops; other site 243233007369 ABC-ATPase subunit interface; other site 243233007370 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 243233007371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 243233007372 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243233007373 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 243233007374 substrate binding site [chemical binding]; other site 243233007375 hexamer interface [polypeptide binding]; other site 243233007376 metal binding site [ion binding]; metal-binding site 243233007377 phosphoglycolate phosphatase; Provisional; Region: PRK13222 243233007378 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243233007379 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233007380 motif II; other site 243233007381 anthranilate synthase component I; Provisional; Region: PRK13565 243233007382 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243233007383 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243233007384 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 243233007385 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243233007386 glutamine binding [chemical binding]; other site 243233007387 catalytic triad [active] 243233007388 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243233007389 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243233007390 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243233007391 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243233007392 active site 243233007393 ribulose/triose binding site [chemical binding]; other site 243233007394 phosphate binding site [ion binding]; other site 243233007395 substrate (anthranilate) binding pocket [chemical binding]; other site 243233007396 product (indole) binding pocket [chemical binding]; other site 243233007397 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 243233007398 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 243233007399 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 243233007400 trimer interface [polypeptide binding]; other site 243233007401 active site 243233007402 UDP-GlcNAc binding site [chemical binding]; other site 243233007403 lipid binding site [chemical binding]; lipid-binding site 243233007404 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 243233007405 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243233007406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233007407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007408 S-adenosylmethionine binding site [chemical binding]; other site 243233007409 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 243233007410 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 243233007411 dimer interface [polypeptide binding]; other site 243233007412 active site 243233007413 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243233007414 catalytic residues [active] 243233007415 substrate binding site [chemical binding]; other site 243233007416 primosome assembly protein PriA; Validated; Region: PRK05580 243233007417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233007418 ATP binding site [chemical binding]; other site 243233007419 putative Mg++ binding site [ion binding]; other site 243233007420 nucleotide binding region [chemical binding]; other site 243233007421 helicase superfamily c-terminal domain; Region: HELICc; smart00490 243233007422 ATP-binding site [chemical binding]; other site 243233007423 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 243233007424 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243233007425 active site 243233007426 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243233007427 pyruvate kinase; Provisional; Region: PRK05826 243233007428 domain interfaces; other site 243233007429 active site 243233007430 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 243233007431 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 243233007432 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243233007433 AAA domain; Region: AAA_32; pfam13654 243233007434 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 243233007435 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243233007436 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 243233007437 putative catalytic site [active] 243233007438 putative metal binding site [ion binding]; other site 243233007439 putative phosphate binding site [ion binding]; other site 243233007440 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 243233007441 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 243233007442 catalytic residues [active] 243233007443 hinge region; other site 243233007444 alpha helical domain; other site 243233007445 Cytochrome c553 [Energy production and conversion]; Region: COG2863 243233007446 Cytochrome c; Region: Cytochrom_C; cl11414 243233007447 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 243233007448 G1 box; other site 243233007449 GTP/Mg2+ binding site [chemical binding]; other site 243233007450 Switch I region; other site 243233007451 G2 box; other site 243233007452 G3 box; other site 243233007453 Switch II region; other site 243233007454 G4 box; other site 243233007455 G5 box; other site 243233007456 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243233007457 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 243233007458 active site 243233007459 catalytic site [active] 243233007460 glycogen synthase; Provisional; Region: glgA; PRK00654 243233007461 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243233007462 ADP-binding pocket [chemical binding]; other site 243233007463 homodimer interface [polypeptide binding]; other site 243233007464 carbon starvation protein A; Provisional; Region: PRK15015 243233007465 Carbon starvation protein CstA; Region: CstA; pfam02554 243233007466 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 243233007467 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 243233007468 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 243233007469 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243233007470 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243233007471 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243233007472 active site 243233007473 dimerization interface [polypeptide binding]; other site 243233007474 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 243233007475 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243233007476 serine O-acetyltransferase; Region: cysE; TIGR01172 243233007477 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243233007478 trimer interface [polypeptide binding]; other site 243233007479 active site 243233007480 substrate binding site [chemical binding]; other site 243233007481 CoA binding site [chemical binding]; other site 243233007482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243233007483 active site residue [active] 243233007484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243233007485 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243233007486 catalytic residues [active] 243233007487 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243233007488 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 243233007489 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243233007490 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 243233007491 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 243233007492 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 243233007493 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 243233007494 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243233007495 SmpB-tmRNA interface; other site 243233007496 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 243233007497 Na2 binding site [ion binding]; other site 243233007498 putative substrate binding site 1 [chemical binding]; other site 243233007499 Na binding site 1 [ion binding]; other site 243233007500 putative substrate binding site 2 [chemical binding]; other site 243233007501 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 243233007502 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 243233007503 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243233007504 metal binding site 2 [ion binding]; metal-binding site 243233007505 putative DNA binding helix; other site 243233007506 metal binding site 1 [ion binding]; metal-binding site 243233007507 dimer interface [polypeptide binding]; other site 243233007508 structural Zn2+ binding site [ion binding]; other site 243233007509 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 243233007510 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243233007511 FtsX-like permease family; Region: FtsX; pfam02687 243233007512 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 243233007513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243233007514 Walker A/P-loop; other site 243233007515 ATP binding site [chemical binding]; other site 243233007516 Q-loop/lid; other site 243233007517 ABC transporter signature motif; other site 243233007518 Walker B; other site 243233007519 D-loop; other site 243233007520 H-loop/switch region; other site 243233007521 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 243233007522 ComEC family competence protein; Provisional; Region: PRK11539 243233007523 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 243233007524 Competence protein; Region: Competence; pfam03772 243233007525 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243233007526 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 243233007527 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243233007528 CysD dimerization site [polypeptide binding]; other site 243233007529 G1 box; other site 243233007530 putative GEF interaction site [polypeptide binding]; other site 243233007531 GTP/Mg2+ binding site [chemical binding]; other site 243233007532 Switch I region; other site 243233007533 G2 box; other site 243233007534 G3 box; other site 243233007535 Switch II region; other site 243233007536 G4 box; other site 243233007537 G5 box; other site 243233007538 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243233007539 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243233007540 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243233007541 active site 243233007542 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 243233007543 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243233007544 Active Sites [active] 243233007545 MCA_PHAGE01; lysogenic bacteriophage with best hits to Wolbachia prophages. insertion into T-loop of tmRNA. attL/Rcore=cccaaggccaacc[gc]tt[cg]tcggttggcctt. 243233007546 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 243233007547 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 243233007548 catalytic residues [active] 243233007549 catalytic nucleophile [active] 243233007550 Presynaptic Site I dimer interface [polypeptide binding]; other site 243233007551 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 243233007552 Synaptic Flat tetramer interface [polypeptide binding]; other site 243233007553 Synaptic Site I dimer interface [polypeptide binding]; other site 243233007554 DNA binding site [nucleotide binding] 243233007555 Recombinase; Region: Recombinase; pfam07508 243233007556 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 243233007557 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 243233007558 PIN domain; Region: PIN_3; pfam13470 243233007559 DNA binding domain, excisionase family; Region: excise; TIGR01764 243233007560 Helix-turn-helix domain; Region: HTH_17; pfam12728 243233007561 Prophage antirepressor [Transcription]; Region: COG3617 243233007562 BRO family, N-terminal domain; Region: Bro-N; smart01040 243233007563 AAA domain; Region: AAA_24; pfam13479 243233007564 hypothetical protein; Validated; Region: PRK07078 243233007565 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 243233007566 active site 243233007567 metal binding site [ion binding]; metal-binding site 243233007568 interdomain interaction site; other site 243233007569 D5 N terminal like; Region: D5_N; smart00885 243233007570 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 243233007571 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 243233007572 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 243233007573 ParB-like nuclease domain; Region: ParBc; cl02129 243233007574 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 243233007575 DNA methylase; Region: N6_N4_Mtase; pfam01555 243233007576 ParB-like nuclease domain; Region: ParBc; pfam02195 243233007577 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 243233007578 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 243233007579 DNA methylase; Region: N6_N4_Mtase; pfam01555 243233007580 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 243233007581 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 243233007582 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 243233007583 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 243233007584 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 243233007585 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 243233007586 tandem repeat interface [polypeptide binding]; other site 243233007587 oligomer interface [polypeptide binding]; other site 243233007588 active site residues [active] 243233007589 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 243233007590 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 243233007591 adhesin; Provisional; Region: PRK09752 243233007592 Phage-related minor tail protein [Function unknown]; Region: COG5281 243233007593 tape measure domain; Region: tape_meas_nterm; TIGR02675 243233007594 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 243233007595 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 243233007596 catalytic residues [active] 243233007597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233007598 ATP binding site [chemical binding]; other site 243233007599 putative Mg++ binding site [ion binding]; other site 243233007600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233007601 nucleotide binding region [chemical binding]; other site 243233007602 ATP-binding site [chemical binding]; other site 243233007603 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 243233007604 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 243233007605 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243233007606 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 243233007607 Transposase domain (DUF772); Region: DUF772; pfam05598 243233007608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233007609 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233007610 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 243233007611 DNA-binding interface [nucleotide binding]; DNA binding site 243233007612 HTH-like domain; Region: HTH_21; pfam13276 243233007613 Integrase core domain; Region: rve; pfam00665 243233007614 Integrase core domain; Region: rve_3; pfam13683 243233007615 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243233007616 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243233007617 dimer interface [polypeptide binding]; other site 243233007618 ssDNA binding site [nucleotide binding]; other site 243233007619 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243233007620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243233007621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243233007622 putative substrate translocation pore; other site 243233007623 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 243233007624 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243233007625 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243233007626 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243233007627 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243233007628 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 243233007629 F0F1 ATP synthase subunit A; Provisional; Region: PRK13420 243233007630 ATP synthase subunit C; Region: ATP-synt_C; cl00466 243233007631 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 243233007632 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 243233007633 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 243233007634 cleavage site 243233007635 active site 243233007636 substrate binding sites [chemical binding]; other site 243233007637 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 243233007638 active site 243233007639 catalytic triad [active] 243233007640 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 243233007641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233007642 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 243233007643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243233007644 Walker A motif; other site 243233007645 ATP binding site [chemical binding]; other site 243233007646 Walker B motif; other site 243233007647 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 243233007648 core domain interface [polypeptide binding]; other site 243233007649 delta subunit interface [polypeptide binding]; other site 243233007650 epsilon subunit interface [polypeptide binding]; other site 243233007651 Domain of unknown function DUF20; Region: UPF0118; pfam01594 243233007652 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243233007653 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 243233007654 ThiC-associated domain; Region: ThiC-associated; pfam13667 243233007655 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 243233007656 Cytochrome P450; Region: p450; cl12078 243233007657 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 243233007658 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 243233007659 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 243233007660 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 243233007661 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 243233007662 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243233007663 putative active site [active] 243233007664 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 243233007665 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 243233007666 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243233007667 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 243233007668 Uncharacterized conserved protein [Function unknown]; Region: COG1615 243233007669 Outer membrane efflux protein; Region: OEP; pfam02321 243233007670 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243233007671 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243233007672 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233007673 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243233007674 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 243233007675 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, hoxF; composed of proteins similar to the NAD-reducing hydrogenase (hoxS) alpha subunit of Alcaligenes eutrophus H16. HoxS is a cytoplasmic hydrogenase...; Region: TRX_Fd_NuoE_hoxF; cd03083 243233007676 putative dimer interface [polypeptide binding]; other site 243233007677 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243233007678 SLBB domain; Region: SLBB; pfam10531 243233007679 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243233007680 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 243233007681 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243233007682 catalytic loop [active] 243233007683 iron binding site [ion binding]; other site 243233007684 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243233007685 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243233007686 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 243233007687 thymidylate synthase; Reviewed; Region: thyA; PRK01827 243233007688 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 243233007689 dimerization interface [polypeptide binding]; other site 243233007690 active site 243233007691 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 243233007692 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243233007693 folate binding site [chemical binding]; other site 243233007694 NADP+ binding site [chemical binding]; other site 243233007695 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 243233007696 trimer interface [polypeptide binding]; other site 243233007697 dimer interface [polypeptide binding]; other site 243233007698 putative active site [active] 243233007699 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 243233007700 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1665 243233007701 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243233007702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233007703 motif II; other site 243233007704 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 243233007705 Citrate transporter; Region: CitMHS; pfam03600 243233007706 ribonuclease Z; Provisional; Region: PRK02126 243233007707 3-hexulose-6-phosphate synthase; Region: RuMP_HxlA; TIGR03128 243233007708 phosphate binding site [ion binding]; other site 243233007709 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243233007710 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 243233007711 tetramer interface [polypeptide binding]; other site 243233007712 active site 243233007713 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243233007714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233007715 active site 243233007716 MoxR-like ATPases [General function prediction only]; Region: COG0714 243233007717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233007718 Walker A motif; other site 243233007719 ATP binding site [chemical binding]; other site 243233007720 Walker B motif; other site 243233007721 arginine finger; other site 243233007722 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243233007723 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 243233007724 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 243233007725 dimer interface [polypeptide binding]; other site 243233007726 catalytic residue [active] 243233007727 metal binding site [ion binding]; metal-binding site 243233007728 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 243233007729 multimerization interface [polypeptide binding]; other site 243233007730 MoxR-like ATPases [General function prediction only]; Region: COG0714 243233007731 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 243233007732 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243233007733 CBD_II domain; Region: CBD_II; smart00637 243233007734 Cellulose binding domain; Region: CBM_2; cl17741 243233007735 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 243233007736 active site 243233007737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243233007738 dimerization interface [polypeptide binding]; other site 243233007739 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243233007740 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243233007741 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 243233007742 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243233007743 N-terminal plug; other site 243233007744 ligand-binding site [chemical binding]; other site 243233007745 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 243233007746 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243233007747 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 243233007748 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 243233007749 Sodium Bile acid symporter family; Region: SBF; cl17470 243233007750 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243233007751 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 243233007752 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 243233007753 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 243233007754 active site 243233007755 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 243233007756 Isochorismatase family; Region: Isochorismatase; pfam00857 243233007757 catalytic triad [active] 243233007758 metal binding site [ion binding]; metal-binding site 243233007759 conserved cis-peptide bond; other site 243233007760 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 243233007761 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 243233007762 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 243233007763 Domain of unknown function DUF29; Region: DUF29; pfam01724 243233007764 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 243233007765 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 243233007766 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 243233007767 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 243233007768 ligand binding site [chemical binding]; other site 243233007769 homodimer interface [polypeptide binding]; other site 243233007770 NAD(P) binding site [chemical binding]; other site 243233007771 trimer interface B [polypeptide binding]; other site 243233007772 trimer interface A [polypeptide binding]; other site 243233007773 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 243233007774 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 243233007775 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243233007776 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 243233007777 proline aminopeptidase P II; Provisional; Region: PRK10879 243233007778 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 243233007779 active site 243233007780 hypothetical protein; Reviewed; Region: PRK02166 243233007781 Cell division protein ZapA; Region: ZapA; pfam05164 243233007782 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 243233007783 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 243233007784 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 243233007785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233007786 active site 243233007787 phosphorylation site [posttranslational modification] 243233007788 intermolecular recognition site; other site 243233007789 dimerization interface [polypeptide binding]; other site 243233007790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243233007791 DNA binding residues [nucleotide binding] 243233007792 dimerization interface [polypeptide binding]; other site 243233007793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243233007794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233007795 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 243233007796 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 243233007797 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243233007798 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243233007799 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243233007800 feedback inhibition sensing region; other site 243233007801 homohexameric interface [polypeptide binding]; other site 243233007802 carbamate kinase; Reviewed; Region: PRK12686 243233007803 nucleotide binding site [chemical binding]; other site 243233007804 N-acetyl-L-glutamate binding site [chemical binding]; other site 243233007805 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243233007806 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 243233007807 active site 243233007808 substrate binding site [chemical binding]; other site 243233007809 metal binding site [ion binding]; metal-binding site 243233007810 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243233007811 trimer interface [polypeptide binding]; other site 243233007812 active site 243233007813 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 243233007814 Flavoprotein; Region: Flavoprotein; pfam02441 243233007815 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 243233007816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 243233007817 SEC-C motif; Region: SEC-C; pfam02810 243233007818 SEC-C motif; Region: SEC-C; pfam02810 243233007819 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 243233007820 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 243233007821 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 243233007822 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 243233007823 putative NAD(P) binding site [chemical binding]; other site 243233007824 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243233007825 NlpC/P60 family; Region: NLPC_P60; pfam00877 243233007826 Methyltransferase domain; Region: Methyltransf_23; pfam13489 243233007827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007828 S-adenosylmethionine binding site [chemical binding]; other site 243233007829 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 243233007830 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 243233007831 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 243233007832 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 243233007833 dimer interface [polypeptide binding]; other site 243233007834 allosteric magnesium binding site [ion binding]; other site 243233007835 active site 243233007836 aspartate-rich active site metal binding site; other site 243233007837 Schiff base residues; other site 243233007838 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 243233007839 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243233007840 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243233007841 NAD(P) binding site [chemical binding]; other site 243233007842 shikimate binding site; other site 243233007843 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 243233007844 Family description; Region: VCBS; pfam13517 243233007845 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243233007846 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243233007847 trimer interface [polypeptide binding]; other site 243233007848 putative metal binding site [ion binding]; other site 243233007849 LemA family; Region: LemA; cl00742 243233007850 E3 Ubiquitin ligase; Region: GIDE; pfam12483 243233007851 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 243233007852 metal binding site [ion binding]; metal-binding site 243233007853 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243233007854 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243233007855 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243233007856 substrate binding site [chemical binding]; other site 243233007857 glutamase interaction surface [polypeptide binding]; other site 243233007858 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243233007859 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 243233007860 catalytic residues [active] 243233007861 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 243233007862 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243233007863 putative active site [active] 243233007864 oxyanion strand; other site 243233007865 catalytic triad [active] 243233007866 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243233007867 putative active site pocket [active] 243233007868 4-fold oligomerization interface [polypeptide binding]; other site 243233007869 metal binding residues [ion binding]; metal-binding site 243233007870 3-fold/trimer interface [polypeptide binding]; other site 243233007871 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 243233007872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233007873 catalytic residue [active] 243233007874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243233007876 S-adenosylmethionine binding site [chemical binding]; other site 243233007877 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 243233007878 putative dimer interface [polypeptide binding]; other site 243233007879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 243233007880 Transposase domain (DUF772); Region: DUF772; pfam05598 243233007881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233007882 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233007883 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243233007884 MarR family; Region: MarR_2; pfam12802 243233007885 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 243233007886 4Fe-4S binding domain; Region: Fer4; pfam00037 243233007887 SCP-2 sterol transfer family; Region: SCP2; pfam02036 243233007888 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243233007889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243233007890 HlyD family secretion protein; Region: HlyD_3; pfam13437 243233007891 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243233007892 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243233007893 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 243233007894 electron transport complex RsxE subunit; Provisional; Region: PRK12405 243233007895 FMN-binding domain; Region: FMN_bind; cl01081 243233007896 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 243233007897 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 243233007898 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243233007899 SLBB domain; Region: SLBB; pfam10531 243233007900 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243233007901 electron transport complex protein RnfB; Provisional; Region: PRK05113 243233007902 Putative Fe-S cluster; Region: FeS; pfam04060 243233007903 4Fe-4S binding domain; Region: Fer4; cl02805 243233007904 4Fe-4S binding domain; Region: Fer4; cl02805 243233007905 electron transport complex protein RsxA; Provisional; Region: PRK05151 243233007906 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 243233007907 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 243233007908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243233007909 active site 243233007910 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243233007911 DNA-binding site [nucleotide binding]; DNA binding site 243233007912 RNA-binding motif; other site 243233007913 Amino acid permease; Region: AA_permease_2; pfam13520 243233007914 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 243233007915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007916 S-adenosylmethionine binding site [chemical binding]; other site 243233007917 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233007918 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233007919 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233007920 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 243233007921 Domain of unknown function (DUF364); Region: DUF364; pfam04016 243233007922 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 243233007923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233007924 Walker A/P-loop; other site 243233007925 ATP binding site [chemical binding]; other site 243233007926 Q-loop/lid; other site 243233007927 ABC transporter signature motif; other site 243233007928 Walker B; other site 243233007929 D-loop; other site 243233007930 H-loop/switch region; other site 243233007931 TOBE domain; Region: TOBE; cl01440 243233007932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243233007933 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 243233007934 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 243233007935 DNA topoisomerase I; Validated; Region: PRK06599 243233007936 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243233007937 active site 243233007938 interdomain interaction site; other site 243233007939 putative metal-binding site [ion binding]; other site 243233007940 nucleotide binding site [chemical binding]; other site 243233007941 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243233007942 domain I; other site 243233007943 DNA binding groove [nucleotide binding] 243233007944 phosphate binding site [ion binding]; other site 243233007945 domain II; other site 243233007946 domain III; other site 243233007947 nucleotide binding site [chemical binding]; other site 243233007948 catalytic site [active] 243233007949 domain IV; other site 243233007950 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243233007951 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243233007952 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243233007953 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243233007954 Protein of unknown function (DUF494); Region: DUF494; pfam04361 243233007955 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 243233007956 DNA protecting protein DprA; Region: dprA; TIGR00732 243233007957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243233007958 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243233007959 active site 243233007960 catalytic residues [active] 243233007961 metal binding site [ion binding]; metal-binding site 243233007962 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243233007963 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243233007964 putative active site [active] 243233007965 substrate binding site [chemical binding]; other site 243233007966 putative cosubstrate binding site; other site 243233007967 catalytic site [active] 243233007968 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243233007969 substrate binding site [chemical binding]; other site 243233007970 16S rRNA methyltransferase B; Provisional; Region: PRK10901 243233007971 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 243233007972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233007973 S-adenosylmethionine binding site [chemical binding]; other site 243233007974 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 243233007975 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 243233007976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243233007977 dimerization interface [polypeptide binding]; other site 243233007978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233007979 putative active site [active] 243233007980 heme pocket [chemical binding]; other site 243233007981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233007982 dimer interface [polypeptide binding]; other site 243233007983 phosphorylation site [posttranslational modification] 243233007984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233007985 ATP binding site [chemical binding]; other site 243233007986 Mg2+ binding site [ion binding]; other site 243233007987 G-X-G motif; other site 243233007988 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243233007989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233007990 active site 243233007991 phosphorylation site [posttranslational modification] 243233007992 intermolecular recognition site; other site 243233007993 dimerization interface [polypeptide binding]; other site 243233007994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233007995 Walker A motif; other site 243233007996 ATP binding site [chemical binding]; other site 243233007997 Walker B motif; other site 243233007998 arginine finger; other site 243233007999 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 243233008000 TrkA-N domain; Region: TrkA_N; pfam02254 243233008001 TrkA-C domain; Region: TrkA_C; pfam02080 243233008002 TrkA-N domain; Region: TrkA_N; pfam02254 243233008003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233008004 S-adenosylmethionine binding site [chemical binding]; other site 243233008005 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 243233008006 active site residue [active] 243233008007 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243233008008 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243233008009 G1 box; other site 243233008010 putative GEF interaction site [polypeptide binding]; other site 243233008011 GTP/Mg2+ binding site [chemical binding]; other site 243233008012 Switch I region; other site 243233008013 G2 box; other site 243233008014 G3 box; other site 243233008015 Switch II region; other site 243233008016 G4 box; other site 243233008017 G5 box; other site 243233008018 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243233008019 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243233008020 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 243233008021 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 243233008022 Ammonia monooxygenase; Region: AMO; pfam02461 243233008023 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; pfam04896 243233008024 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 243233008025 putative subunit interface; other site 243233008026 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 243233008027 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 243233008028 FTR, proximal lobe; Region: FTR_C; pfam02741 243233008029 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 243233008030 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 243233008031 active site 243233008032 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 243233008033 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 243233008034 putative [4Fe-4S] binding site [ion binding]; other site 243233008035 putative molybdopterin cofactor binding site [chemical binding]; other site 243233008036 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 243233008037 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243233008038 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 243233008039 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 243233008040 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243233008041 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 243233008042 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 243233008043 trimer interface I [polypeptide binding]; other site 243233008044 putative substrate binding pocket [chemical binding]; other site 243233008045 trimer interface II [polypeptide binding]; other site 243233008046 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 243233008047 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243233008048 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 243233008049 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 243233008050 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 243233008051 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 243233008052 active site 243233008053 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 243233008054 ATP-grasp domain; Region: ATP-grasp_3; pfam02655 243233008055 probable H4MPT-linked C1 transfer pathway protein; Region: one_C_unchar_1; TIGR03123 243233008056 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243233008057 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 243233008058 chorismate binding enzyme; Region: Chorismate_bind; cl10555 243233008059 AAK_UC: Uncharacterized (UC) amino acid kinase-like proteins found mainly in archaea and a few bacteria. Sequences in this CD are members of the Amino Acid Kinase (AAK) superfamily; Region: AAK_UC; cd04240 243233008060 putative nucleotide binding site [chemical binding]; other site 243233008061 putative substrate binding site [chemical binding]; other site 243233008062 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 243233008063 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 243233008064 hypothetical protein; Provisional; Region: PRK07236 243233008065 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 243233008066 2,3-oxidosqualene cyclase; Region: osq_cycl; TIGR03463 243233008067 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 243233008068 putative heme binding site [chemical binding]; other site 243233008069 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 243233008070 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 243233008071 active site 1 [active] 243233008072 dimer interface [polypeptide binding]; other site 243233008073 active site 2 [active] 243233008074 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 243233008075 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243233008076 dimer interface [polypeptide binding]; other site 243233008077 active site 243233008078 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 243233008079 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 243233008080 Ligand Binding Site [chemical binding]; other site 243233008081 Transcriptional regulator; Region: Rrf2; cl17282 243233008082 Rrf2 family protein; Region: rrf2_super; TIGR00738 243233008083 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243233008084 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243233008085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243233008086 catalytic residue [active] 243233008087 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 243233008088 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243233008089 active site 243233008090 multimer interface [polypeptide binding]; other site 243233008091 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 243233008092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233008093 FeS/SAM binding site; other site 243233008094 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 243233008095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233008096 binding surface 243233008097 TPR motif; other site 243233008098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243233008099 binding surface 243233008100 TPR motif; other site 243233008101 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 243233008102 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243233008103 dimer interface [polypeptide binding]; other site 243233008104 motif 1; other site 243233008105 active site 243233008106 motif 2; other site 243233008107 motif 3; other site 243233008108 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 243233008109 anticodon binding site; other site 243233008110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 243233008111 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 243233008112 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 243233008113 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 243233008114 Trp docking motif [polypeptide binding]; other site 243233008115 active site 243233008116 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 243233008117 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243233008118 G1 box; other site 243233008119 GTP/Mg2+ binding site [chemical binding]; other site 243233008120 Switch I region; other site 243233008121 G2 box; other site 243233008122 Switch II region; other site 243233008123 G3 box; other site 243233008124 G4 box; other site 243233008125 G5 box; other site 243233008126 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243233008127 G1 box; other site 243233008128 GTP/Mg2+ binding site [chemical binding]; other site 243233008129 Switch I region; other site 243233008130 G2 box; other site 243233008131 G3 box; other site 243233008132 Switch II region; other site 243233008133 G4 box; other site 243233008134 G5 box; other site 243233008135 electron transport complex protein RsxA; Provisional; Region: PRK05151 243233008136 electron transport complex protein RnfB; Provisional; Region: PRK05113 243233008137 Putative Fe-S cluster; Region: FeS; pfam04060 243233008138 4Fe-4S binding domain; Region: Fer4; pfam00037 243233008139 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 243233008140 SLBB domain; Region: SLBB; pfam10531 243233008141 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 243233008142 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 243233008143 FMN-binding domain; Region: FMN_bind; cl01081 243233008144 electron transport complex RsxE subunit; Provisional; Region: PRK12405 243233008145 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243233008146 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243233008147 minor groove reading motif; other site 243233008148 helix-hairpin-helix signature motif; other site 243233008149 substrate binding pocket [chemical binding]; other site 243233008150 active site 243233008151 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 243233008152 MCA_PHAGE02; Mu-like bacteriophage. No target-site duplication resolved. 243233008153 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 243233008154 DNA methylase; Region: N6_N4_Mtase; pfam01555 243233008155 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 243233008156 Baseplate J-like protein; Region: Baseplate_J; cl01294 243233008157 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 243233008158 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 243233008159 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 243233008160 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243233008161 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 243233008162 Phage Tail Protein X; Region: Phage_tail_X; cl02088 243233008163 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 243233008164 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 243233008165 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 243233008166 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 243233008167 Phage tail tube protein FII; Region: Phage_tube; pfam04985 243233008168 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 243233008169 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 243233008170 Gp37 protein; Region: Gp37; pfam09646 243233008171 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 243233008172 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 243233008173 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 243233008174 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 243233008175 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 243233008176 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 243233008177 thioester formation/cholesterol transfer; other site 243233008178 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 243233008179 Protein of unknown function (DUF935); Region: DUF935; pfam06074 243233008180 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 243233008181 Terminase-like family; Region: Terminase_6; pfam03237 243233008182 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 243233008183 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 243233008184 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 243233008185 virion protein; Provisional; Region: V; PHA02564 243233008186 Staphylococcal nuclease homologues; Region: SNc; smart00318 243233008187 Catalytic site; other site 243233008188 Staphylococcal nuclease homologue; Region: SNase; pfam00565 243233008189 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 243233008190 Mor transcription activator family; Region: Mor; pfam08765 243233008191 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 243233008192 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 243233008193 IHF dimer interface [polypeptide binding]; other site 243233008194 IHF - DNA interface [nucleotide binding]; other site 243233008195 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 243233008196 AAA domain; Region: AAA_22; pfam13401 243233008197 Integrase core domain; Region: rve; pfam00665 243233008198 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 243233008199 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 243233008200 Predicted transcriptional regulator [Transcription]; Region: COG2932 243233008201 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243233008202 Catalytic site [active] 243233008203 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243233008204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233008205 Domain of unknown function (DUF336); Region: DUF336; cl01249 243233008206 Transposase domain (DUF772); Region: DUF772; pfam05598 243233008207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243233008208 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243233008209 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 243233008210 Protein of unknown function (DUF989); Region: DUF989; pfam06181 243233008211 Protein of unknown function (DUF989); Region: DUF989; pfam06181 243233008212 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243233008213 EamA-like transporter family; Region: EamA; pfam00892 243233008214 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 243233008215 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 243233008216 putative ligand binding site [chemical binding]; other site 243233008217 NAD binding site [chemical binding]; other site 243233008218 dimer interface [polypeptide binding]; other site 243233008219 putative catalytic site [active] 243233008220 Uncharacterized conserved protein [Function unknown]; Region: COG1739 243233008221 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 243233008222 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 243233008223 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 243233008224 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 243233008225 putative active site [active] 243233008226 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 243233008227 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 243233008228 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 243233008229 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 243233008230 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243233008231 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 243233008232 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 243233008233 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 243233008234 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 243233008235 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 243233008236 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 243233008237 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243233008238 catalytic site [active] 243233008239 G-X2-G-X-G-K; other site 243233008240 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 243233008241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233008242 active site 243233008243 phosphorylation site [posttranslational modification] 243233008244 intermolecular recognition site; other site 243233008245 dimerization interface [polypeptide binding]; other site 243233008246 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243233008247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243233008248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 243233008249 dimer interface [polypeptide binding]; other site 243233008250 phosphorylation site [posttranslational modification] 243233008251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233008252 ATP binding site [chemical binding]; other site 243233008253 Mg2+ binding site [ion binding]; other site 243233008254 G-X-G motif; other site 243233008255 Peptidase family M48; Region: Peptidase_M48; pfam01435 243233008256 methionine sulfoxide reductase A; Provisional; Region: PRK00058 243233008257 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 243233008258 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 243233008259 dimerization interface [polypeptide binding]; other site 243233008260 domain crossover interface; other site 243233008261 redox-dependent activation switch; other site 243233008262 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 243233008263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243233008264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243233008265 motif II; other site 243233008266 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 243233008267 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 243233008268 active site 243233008269 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 243233008270 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 243233008271 active site 243233008272 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243233008273 pteridine reductase; Provisional; Region: PRK09135 243233008274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243233008275 NAD(P) binding site [chemical binding]; other site 243233008276 active site 243233008277 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243233008278 catalytic center binding site [active] 243233008279 ATP binding site [chemical binding]; other site 243233008280 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 243233008281 homooctamer interface [polypeptide binding]; other site 243233008282 active site 243233008283 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 243233008284 UGMP family protein; Validated; Region: PRK09604 243233008285 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 243233008286 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243233008287 Yqey-like protein; Region: YqeY; pfam09424 243233008288 DNA primase; Validated; Region: dnaG; PRK05667 243233008289 CHC2 zinc finger; Region: zf-CHC2; pfam01807 243233008290 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243233008291 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243233008292 active site 243233008293 metal binding site [ion binding]; metal-binding site 243233008294 interdomain interaction site; other site 243233008295 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 243233008296 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 243233008297 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243233008298 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 243233008299 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243233008300 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 243233008301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243233008302 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243233008303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243233008304 DNA binding residues [nucleotide binding] 243233008305 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 243233008306 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243233008307 substrate binding pocket [chemical binding]; other site 243233008308 chain length determination region; other site 243233008309 substrate-Mg2+ binding site; other site 243233008310 catalytic residues [active] 243233008311 aspartate-rich region 1; other site 243233008312 active site lid residues [active] 243233008313 aspartate-rich region 2; other site 243233008314 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 243233008315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243233008316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243233008317 homodimer interface [polypeptide binding]; other site 243233008318 catalytic residue [active] 243233008319 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243233008320 thiamine phosphate binding site [chemical binding]; other site 243233008321 active site 243233008322 pyrophosphate binding site [ion binding]; other site 243233008323 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 243233008324 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 243233008325 dimer interface [polypeptide binding]; other site 243233008326 TPP-binding site [chemical binding]; other site 243233008327 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 243233008328 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243233008329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243233008330 E3 interaction surface; other site 243233008331 lipoyl attachment site [posttranslational modification]; other site 243233008332 e3 binding domain; Region: E3_binding; pfam02817 243233008333 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243233008334 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 243233008335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243233008336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233008337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243233008338 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 243233008339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233008340 S-adenosylmethionine binding site [chemical binding]; other site 243233008341 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 243233008342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243233008343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243233008344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243233008345 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243233008346 active site residue [active] 243233008347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243233008348 ATP binding site [chemical binding]; other site 243233008349 putative Mg++ binding site [ion binding]; other site 243233008350 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243233008351 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 243233008352 nucleotide binding region [chemical binding]; other site 243233008353 ATP-binding site [chemical binding]; other site 243233008354 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 243233008355 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 243233008356 PemK-like protein; Region: PemK; pfam02452 243233008357 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 243233008358 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 243233008359 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 243233008360 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243233008361 active site 243233008362 AAA domain; Region: AAA_23; pfam13476 243233008363 AAA domain; Region: AAA_21; pfam13304 243233008364 Divergent AAA domain; Region: AAA_4; pfam04326 243233008365 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 243233008366 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 243233008367 Protein of unknown function (DUF499); Region: DUF499; pfam04465 243233008368 TIR domain; Region: TIR_2; pfam13676 243233008369 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243233008370 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 243233008371 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 243233008372 Sulphur transport; Region: Sulf_transp; pfam04143 243233008373 Predicted transporter component [General function prediction only]; Region: COG2391 243233008374 Sulphur transport; Region: Sulf_transp; pfam04143 243233008375 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 243233008376 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 243233008377 NAD(P) binding pocket [chemical binding]; other site 243233008378 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 243233008379 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 243233008380 NADP binding site [chemical binding]; other site 243233008381 pyruvate phosphate dikinase; Provisional; Region: PRK09279 243233008382 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243233008383 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243233008384 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243233008385 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243233008386 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 243233008387 gamma subunit interface [polypeptide binding]; other site 243233008388 epsilon subunit interface [polypeptide binding]; other site 243233008389 LBP interface [polypeptide binding]; other site 243233008390 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 243233008391 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243233008392 active site 243233008393 dimerization interface [polypeptide binding]; other site 243233008394 ribonuclease PH; Reviewed; Region: rph; PRK00173 243233008395 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243233008396 hexamer interface [polypeptide binding]; other site 243233008397 active site 243233008398 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 243233008399 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 243233008400 active site 243233008401 hypothetical protein; Provisional; Region: PRK11820 243233008402 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 243233008403 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 243233008404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 243233008405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243233008406 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 243233008407 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243233008408 active site 243233008409 Int/Topo IB signature motif; other site 243233008410 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 243233008411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233008412 ATP binding site [chemical binding]; other site 243233008413 Mg2+ binding site [ion binding]; other site 243233008414 G-X-G motif; other site 243233008415 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243233008416 anchoring element; other site 243233008417 dimer interface [polypeptide binding]; other site 243233008418 ATP binding site [chemical binding]; other site 243233008419 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243233008420 active site 243233008421 putative metal-binding site [ion binding]; other site 243233008422 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243233008423 recombination protein F; Reviewed; Region: recF; PRK00064 243233008424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233008425 Walker A/P-loop; other site 243233008426 ATP binding site [chemical binding]; other site 243233008427 Q-loop/lid; other site 243233008428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233008429 ABC transporter signature motif; other site 243233008430 Walker B; other site 243233008431 D-loop; other site 243233008432 H-loop/switch region; other site 243233008433 DNA polymerase III subunit beta; Validated; Region: PRK05643 243233008434 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243233008435 putative DNA binding surface [nucleotide binding]; other site 243233008436 dimer interface [polypeptide binding]; other site 243233008437 beta-clamp/clamp loader binding surface; other site 243233008438 beta-clamp/translesion DNA polymerase binding surface; other site 243233008439 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 243233008440 DnaA N-terminal domain; Region: DnaA_N; pfam11638 243233008441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233008442 Walker A motif; other site 243233008443 ATP binding site [chemical binding]; other site 243233008444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 243233008445 Walker B motif; other site 243233008446 arginine finger; other site 243233008447 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243233008448 DnaA box-binding interface [nucleotide binding]; other site 243233008449 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 243233008450 Ribonuclease P; Region: Ribonuclease_P; cl00457 243233008451 Haemolytic domain; Region: Haemolytic; pfam01809 243233008452 membrane protein insertase; Provisional; Region: PRK01318 243233008453 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 243233008454 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 243233008455 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243233008456 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243233008457 G1 box; other site 243233008458 GTP/Mg2+ binding site [chemical binding]; other site 243233008459 Switch I region; other site 243233008460 G2 box; other site 243233008461 Switch II region; other site 243233008462 G3 box; other site 243233008463 G4 box; other site 243233008464 G5 box; other site 243233008465 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243233008466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243233008467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243233008468 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 243233008469 putative dimerization interface [polypeptide binding]; other site 243233008470 transketolase; Reviewed; Region: PRK12753 243233008471 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243233008472 TPP-binding site [chemical binding]; other site 243233008473 dimer interface [polypeptide binding]; other site 243233008474 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243233008475 PYR/PP interface [polypeptide binding]; other site 243233008476 dimer interface [polypeptide binding]; other site 243233008477 TPP binding site [chemical binding]; other site 243233008478 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243233008479 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 243233008480 intersubunit interface [polypeptide binding]; other site 243233008481 active site 243233008482 zinc binding site [ion binding]; other site 243233008483 Na+ binding site [ion binding]; other site 243233008484 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 243233008485 active site 243233008486 dimer interface [polypeptide binding]; other site 243233008487 magnesium binding site [ion binding]; other site 243233008488 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 243233008489 tetramer interface [polypeptide binding]; other site 243233008490 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243233008491 active site 243233008492 transaldolase-like protein; Provisional; Region: PTZ00411 243233008493 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 243233008494 active site 243233008495 dimer interface [polypeptide binding]; other site 243233008496 catalytic residue [active] 243233008497 transketolase; Reviewed; Region: PRK12753 243233008498 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243233008499 TPP-binding site [chemical binding]; other site 243233008500 dimer interface [polypeptide binding]; other site 243233008501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243233008502 PYR/PP interface [polypeptide binding]; other site 243233008503 dimer interface [polypeptide binding]; other site 243233008504 TPP binding site [chemical binding]; other site 243233008505 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243233008506 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 243233008507 intersubunit interface [polypeptide binding]; other site 243233008508 active site 243233008509 zinc binding site [ion binding]; other site 243233008510 Na+ binding site [ion binding]; other site 243233008511 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 243233008512 active site 243233008513 dimer interface [polypeptide binding]; other site 243233008514 magnesium binding site [ion binding]; other site 243233008515 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 243233008516 tetramer interface [polypeptide binding]; other site 243233008517 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243233008518 active site 243233008519 phosphoribulokinase; Provisional; Region: PRK15453 243233008520 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 243233008521 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 243233008522 amidase catalytic site [active] 243233008523 Zn binding residues [ion binding]; other site 243233008524 substrate binding site [chemical binding]; other site 243233008525 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 243233008526 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243233008527 MoaE interaction surface [polypeptide binding]; other site 243233008528 MoeB interaction surface [polypeptide binding]; other site 243233008529 thiocarboxylated glycine; other site 243233008530 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 243233008531 MoaE homodimer interface [polypeptide binding]; other site 243233008532 MoaD interaction [polypeptide binding]; other site 243233008533 active site residues [active] 243233008534 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 243233008535 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 243233008536 Dodecin; Region: Dodecin; pfam07311 243233008537 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 243233008538 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243233008539 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 243233008540 domain interfaces; other site 243233008541 active site 243233008542 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 243233008543 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243233008544 active site 243233008545 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 243233008546 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 243233008547 HemY protein N-terminus; Region: HemY_N; pfam07219 243233008548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 243233008549 TPR motif; other site 243233008550 binding surface 243233008551 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 243233008552 Suppressor of RNA silencing P21-like; Region: RSS_P20; pfam11757 243233008553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243233008554 S-adenosylmethionine binding site [chemical binding]; other site 243233008555 septum formation inhibitor; Reviewed; Region: minC; PRK04804 243233008556 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 243233008557 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 243233008558 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 243233008559 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 243233008560 Switch I; other site 243233008561 Switch II; other site 243233008562 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 243233008563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243233008564 putative DNA binding site [nucleotide binding]; other site 243233008565 putative Zn2+ binding site [ion binding]; other site 243233008566 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 243233008567 putative catalytic site [active] 243233008568 putative phosphate binding site [ion binding]; other site 243233008569 active site 243233008570 metal binding site A [ion binding]; metal-binding site 243233008571 DNA binding site [nucleotide binding] 243233008572 putative AP binding site [nucleotide binding]; other site 243233008573 putative metal binding site B [ion binding]; other site 243233008574 tartrate dehydrogenase; Region: TTC; TIGR02089 243233008575 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 243233008576 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243233008577 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243233008578 DNA binding site [nucleotide binding] 243233008579 catalytic residue [active] 243233008580 H2TH interface [polypeptide binding]; other site 243233008581 putative catalytic residues [active] 243233008582 turnover-facilitating residue; other site 243233008583 intercalation triad [nucleotide binding]; other site 243233008584 8OG recognition residue [nucleotide binding]; other site 243233008585 putative reading head residues; other site 243233008586 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243233008587 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243233008588 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 243233008589 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 243233008590 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 243233008591 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 243233008592 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 243233008593 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 243233008594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243233008595 Walker A/P-loop; other site 243233008596 ATP binding site [chemical binding]; other site 243233008597 Q-loop/lid; other site 243233008598 ABC transporter signature motif; other site 243233008599 Walker B; other site 243233008600 D-loop; other site 243233008601 H-loop/switch region; other site 243233008602 HemN family oxidoreductase; Provisional; Region: PRK05660 243233008603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243233008604 FeS/SAM binding site; other site 243233008605 HemN C-terminal domain; Region: HemN_C; pfam06969 243233008606 Membrane protein of unknown function; Region: DUF360; pfam04020 243233008607 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243233008608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233008609 active site 243233008610 phosphorylation site [posttranslational modification] 243233008611 intermolecular recognition site; other site 243233008612 dimerization interface [polypeptide binding]; other site 243233008613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243233008614 PAS domain; Region: PAS_9; pfam13426 243233008615 putative active site [active] 243233008616 heme pocket [chemical binding]; other site 243233008617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 243233008618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243233008619 metal binding site [ion binding]; metal-binding site 243233008620 active site 243233008621 I-site; other site 243233008622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243233008623 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243233008624 Protein of unknown function DUF58; Region: DUF58; pfam01882 243233008625 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 243233008626 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 243233008627 metal ion-dependent adhesion site (MIDAS); other site 243233008628 von Willebrand factor type A domain; Region: VWA_2; pfam13519 243233008629 metal ion-dependent adhesion site (MIDAS); other site 243233008630 Oxygen tolerance; Region: BatD; pfam13584 243233008631 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 243233008632 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 243233008633 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243233008634 active site 243233008635 HIGH motif; other site 243233008636 nucleotide binding site [chemical binding]; other site 243233008637 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243233008638 KMSK motif region; other site 243233008639 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 243233008640 tRNA binding surface [nucleotide binding]; other site 243233008641 anticodon binding site; other site 243233008642 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 243233008643 Sporulation related domain; Region: SPOR; pfam05036 243233008644 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243233008645 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 243233008646 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 243233008647 ligand binding site [chemical binding]; other site 243233008648 active site 243233008649 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243233008650 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 243233008651 Ligand binding site; other site 243233008652 DXD motif; other site 243233008653 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 243233008654 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 243233008655 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243233008656 catalytic core [active] 243233008657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 243233008658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233008659 dimer interface [polypeptide binding]; other site 243233008660 phosphorylation site [posttranslational modification] 243233008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233008662 ATP binding site [chemical binding]; other site 243233008663 Mg2+ binding site [ion binding]; other site 243233008664 G-X-G motif; other site 243233008665 Response regulator receiver domain; Region: Response_reg; pfam00072 243233008666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233008667 active site 243233008668 phosphorylation site [posttranslational modification] 243233008669 intermolecular recognition site; other site 243233008670 dimerization interface [polypeptide binding]; other site 243233008671 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243233008672 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 243233008673 dimerization interface [polypeptide binding]; other site 243233008674 active site 243233008675 PBP superfamily domain; Region: PBP_like_2; pfam12849 243233008676 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243233008677 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243233008678 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243233008679 ligand binding site [chemical binding]; other site 243233008680 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 243233008681 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243233008682 PAS domain; Region: PAS; smart00091 243233008683 putative active site [active] 243233008684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243233008685 dimer interface [polypeptide binding]; other site 243233008686 phosphorylation site [posttranslational modification] 243233008687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243233008688 ATP binding site [chemical binding]; other site 243233008689 Mg2+ binding site [ion binding]; other site 243233008690 G-X-G motif; other site 243233008691 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 243233008692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243233008693 active site 243233008694 phosphorylation site [posttranslational modification] 243233008695 intermolecular recognition site; other site 243233008696 dimerization interface [polypeptide binding]; other site 243233008697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243233008698 DNA binding site [nucleotide binding] 243233008699 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243233008700 Clp amino terminal domain; Region: Clp_N; pfam02861 243233008701 Clp amino terminal domain; Region: Clp_N; pfam02861 243233008702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233008703 Walker A motif; other site 243233008704 ATP binding site [chemical binding]; other site 243233008705 Walker B motif; other site 243233008706 arginine finger; other site 243233008707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243233008708 Walker A motif; other site 243233008709 ATP binding site [chemical binding]; other site 243233008710 Walker B motif; other site 243233008711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243233008712 hypothetical protein; Provisional; Region: PRK05409 243233008713 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 243233008714 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233008715 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233008716 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243233008717 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 243233008718 ligand binding site [chemical binding]; other site 243233008719 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 243233008720 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 243233008721 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 243233008722 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 243233008723 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 243233008724 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971