-- dump date 20140619_145033 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1091494000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1091494000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1091494000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494000004 Walker A motif; other site 1091494000005 ATP binding site [chemical binding]; other site 1091494000006 Walker B motif; other site 1091494000007 arginine finger; other site 1091494000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1091494000009 DnaA box-binding interface [nucleotide binding]; other site 1091494000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1091494000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1091494000012 putative DNA binding surface [nucleotide binding]; other site 1091494000013 dimer interface [polypeptide binding]; other site 1091494000014 beta-clamp/clamp loader binding surface; other site 1091494000015 beta-clamp/translesion DNA polymerase binding surface; other site 1091494000016 recombination protein F; Reviewed; Region: recF; PRK00064 1091494000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494000018 Walker A/P-loop; other site 1091494000019 ATP binding site [chemical binding]; other site 1091494000020 Q-loop/lid; other site 1091494000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494000022 ABC transporter signature motif; other site 1091494000023 Walker B; other site 1091494000024 D-loop; other site 1091494000025 H-loop/switch region; other site 1091494000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1091494000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494000028 ATP binding site [chemical binding]; other site 1091494000029 Mg2+ binding site [ion binding]; other site 1091494000030 G-X-G motif; other site 1091494000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1091494000032 anchoring element; other site 1091494000033 dimer interface [polypeptide binding]; other site 1091494000034 ATP binding site [chemical binding]; other site 1091494000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1091494000036 active site 1091494000037 putative metal-binding site [ion binding]; other site 1091494000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1091494000039 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1091494000040 Outer membrane efflux protein; Region: OEP; pfam02321 1091494000041 Outer membrane efflux protein; Region: OEP; pfam02321 1091494000042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494000043 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1091494000044 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494000045 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1091494000046 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 1091494000047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494000048 PAS fold; Region: PAS_3; pfam08447 1091494000049 putative active site [active] 1091494000050 heme pocket [chemical binding]; other site 1091494000051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494000052 PAS domain; Region: PAS_9; pfam13426 1091494000053 putative active site [active] 1091494000054 heme pocket [chemical binding]; other site 1091494000055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494000056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494000057 metal binding site [ion binding]; metal-binding site 1091494000058 active site 1091494000059 I-site; other site 1091494000060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494000061 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494000062 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494000063 Integrase core domain; Region: rve; pfam00665 1091494000064 Integrase core domain; Region: rve_3; pfam13683 1091494000065 rod shape-determining protein MreC; Provisional; Region: PRK13922 1091494000066 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1091494000067 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1091494000068 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1091494000069 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091494000070 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1091494000071 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1091494000072 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1091494000073 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1091494000074 dimerization interface [polypeptide binding]; other site 1091494000075 active site 1091494000076 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 1091494000077 metal binding site [ion binding]; metal-binding site 1091494000078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1091494000079 SEC-C motif; Region: SEC-C; pfam02810 1091494000080 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1091494000081 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494000082 ligand binding site [chemical binding]; other site 1091494000083 flexible hinge region; other site 1091494000084 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091494000085 putative switch regulator; other site 1091494000086 non-specific DNA interactions [nucleotide binding]; other site 1091494000087 DNA binding site [nucleotide binding] 1091494000088 sequence specific DNA binding site [nucleotide binding]; other site 1091494000089 putative cAMP binding site [chemical binding]; other site 1091494000090 OsmC-like protein; Region: OsmC; cl00767 1091494000091 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1091494000092 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494000093 Sel1-like repeats; Region: SEL1; smart00671 1091494000094 Sel1-like repeats; Region: SEL1; smart00671 1091494000095 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1091494000096 linker region; other site 1091494000097 Caspase domain; Region: Peptidase_C14; pfam00656 1091494000098 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1091494000099 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1091494000100 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494000101 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494000102 ligand binding site [chemical binding]; other site 1091494000103 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1091494000104 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1091494000105 Caspase domain; Region: Peptidase_C14; pfam00656 1091494000106 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1091494000107 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1091494000108 transcriptional regulator NarL; Provisional; Region: PRK10651 1091494000109 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091494000110 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1091494000111 alpha-glucosidase; Provisional; Region: PRK10137 1091494000112 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1091494000113 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494000114 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494000115 ligand binding site [chemical binding]; other site 1091494000116 flexible hinge region; other site 1091494000117 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091494000118 putative switch regulator; other site 1091494000119 non-specific DNA interactions [nucleotide binding]; other site 1091494000120 DNA binding site [nucleotide binding] 1091494000121 sequence specific DNA binding site [nucleotide binding]; other site 1091494000122 putative cAMP binding site [chemical binding]; other site 1091494000123 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1091494000124 cyclase homology domain; Region: CHD; cd07302 1091494000125 nucleotidyl binding site; other site 1091494000126 metal binding site [ion binding]; metal-binding site 1091494000127 dimer interface [polypeptide binding]; other site 1091494000128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494000129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494000130 active site 1091494000131 ATP binding site [chemical binding]; other site 1091494000132 substrate binding site [chemical binding]; other site 1091494000133 activation loop (A-loop); other site 1091494000134 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1091494000135 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494000136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091494000137 active site 1091494000138 ATP binding site [chemical binding]; other site 1091494000139 substrate binding site [chemical binding]; other site 1091494000140 activation loop (A-loop); other site 1091494000141 Predicted ATPase [General function prediction only]; Region: COG3899 1091494000142 AAA ATPase domain; Region: AAA_16; pfam13191 1091494000143 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494000144 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091494000145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494000146 dimer interface [polypeptide binding]; other site 1091494000147 phosphorylation site [posttranslational modification] 1091494000148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494000149 ATP binding site [chemical binding]; other site 1091494000150 Mg2+ binding site [ion binding]; other site 1091494000151 G-X-G motif; other site 1091494000152 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494000153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494000154 active site 1091494000155 phosphorylation site [posttranslational modification] 1091494000156 intermolecular recognition site; other site 1091494000157 dimerization interface [polypeptide binding]; other site 1091494000158 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494000159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494000160 active site 1091494000161 phosphorylation site [posttranslational modification] 1091494000162 intermolecular recognition site; other site 1091494000163 dimerization interface [polypeptide binding]; other site 1091494000164 PAS fold; Region: PAS; pfam00989 1091494000165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494000166 putative active site [active] 1091494000167 heme pocket [chemical binding]; other site 1091494000168 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494000169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494000170 metal binding site [ion binding]; metal-binding site 1091494000171 active site 1091494000172 I-site; other site 1091494000173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494000174 CAAX protease self-immunity; Region: Abi; pfam02517 1091494000175 YcgL domain; Region: YcgL; pfam05166 1091494000176 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1091494000177 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1091494000178 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091494000179 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091494000180 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091494000181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494000182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494000183 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1091494000184 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091494000185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091494000186 active site 1091494000187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1091494000188 active site 1091494000189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494000190 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1091494000191 putative ADP-binding pocket [chemical binding]; other site 1091494000192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091494000193 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1091494000194 putative NAD(P) binding site [chemical binding]; other site 1091494000195 active site 1091494000196 putative substrate binding site [chemical binding]; other site 1091494000197 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1091494000198 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1091494000199 Mg++ binding site [ion binding]; other site 1091494000200 putative catalytic motif [active] 1091494000201 putative substrate binding site [chemical binding]; other site 1091494000202 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494000203 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1091494000204 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1091494000205 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1091494000206 NAD(P) binding site [chemical binding]; other site 1091494000207 homodimer interface [polypeptide binding]; other site 1091494000208 substrate binding site [chemical binding]; other site 1091494000209 active site 1091494000210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091494000211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494000212 NPR1/NIM1 like defence protein C terminal; Region: NPR1_like_C; pfam12313 1091494000213 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1091494000214 putative effector binding pocket; other site 1091494000215 dimerization interface [polypeptide binding]; other site 1091494000216 tellurite resistance protein TehB; Provisional; Region: PRK12335 1091494000217 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1091494000218 active site residue [active] 1091494000219 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1091494000220 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1091494000221 G1 box; other site 1091494000222 putative GEF interaction site [polypeptide binding]; other site 1091494000223 GTP/Mg2+ binding site [chemical binding]; other site 1091494000224 Switch I region; other site 1091494000225 G2 box; other site 1091494000226 G3 box; other site 1091494000227 Switch II region; other site 1091494000228 G4 box; other site 1091494000229 G5 box; other site 1091494000230 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1091494000231 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1091494000232 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1091494000233 putative active site pocket [active] 1091494000234 4-fold oligomerization interface [polypeptide binding]; other site 1091494000235 metal binding residues [ion binding]; metal-binding site 1091494000236 3-fold/trimer interface [polypeptide binding]; other site 1091494000237 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1091494000238 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1091494000239 putative active site [active] 1091494000240 oxyanion strand; other site 1091494000241 catalytic triad [active] 1091494000242 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1091494000243 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1091494000244 catalytic residues [active] 1091494000245 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1091494000246 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1091494000247 substrate binding site [chemical binding]; other site 1091494000248 glutamase interaction surface [polypeptide binding]; other site 1091494000249 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1091494000250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1091494000251 metal binding site [ion binding]; metal-binding site 1091494000252 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1091494000253 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1091494000254 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1091494000255 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1091494000256 active site 1091494000257 catalytic triad [active] 1091494000258 oxyanion hole [active] 1091494000259 switch loop; other site 1091494000260 pteridine reductase; Provisional; Region: PRK09135 1091494000261 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1091494000262 NADP binding site [chemical binding]; other site 1091494000263 substrate binding pocket [chemical binding]; other site 1091494000264 active site 1091494000265 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1091494000266 active site 1091494000267 ATP binding site [chemical binding]; other site 1091494000268 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1091494000269 catalytic center binding site [active] 1091494000270 ATP binding site [chemical binding]; other site 1091494000271 Dihydroneopterin aldolase; Region: FolB; smart00905 1091494000272 active site 1091494000273 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1091494000274 UGMP family protein; Validated; Region: PRK09604 1091494000275 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1091494000276 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1091494000277 Yqey-like protein; Region: YqeY; pfam09424 1091494000278 DNA primase; Validated; Region: dnaG; PRK05667 1091494000279 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1091494000280 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1091494000281 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1091494000282 active site 1091494000283 metal binding site [ion binding]; metal-binding site 1091494000284 interdomain interaction site; other site 1091494000285 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1091494000286 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1091494000287 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1091494000288 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1091494000289 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1091494000290 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1091494000291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494000292 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091494000293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494000294 DNA binding residues [nucleotide binding] 1091494000295 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1091494000296 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1091494000297 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1091494000298 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1091494000299 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1091494000300 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1091494000301 homotetramer interface [polypeptide binding]; other site 1091494000302 ligand binding site [chemical binding]; other site 1091494000303 catalytic site [active] 1091494000304 NAD binding site [chemical binding]; other site 1091494000305 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1091494000306 FAD binding site [chemical binding]; other site 1091494000307 RNA methyltransferase, RsmE family; Region: TIGR00046 1091494000308 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1091494000309 CAAX protease self-immunity; Region: Abi; pfam02517 1091494000310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1091494000311 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1091494000312 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1091494000313 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1091494000314 active site 1091494000315 NTP binding site [chemical binding]; other site 1091494000316 metal binding triad [ion binding]; metal-binding site 1091494000317 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1091494000318 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1091494000319 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1091494000320 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1091494000321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1091494000322 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1091494000323 active site 1091494000324 GMP synthase; Reviewed; Region: guaA; PRK00074 1091494000325 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1091494000326 AMP/PPi binding site [chemical binding]; other site 1091494000327 candidate oxyanion hole; other site 1091494000328 catalytic triad [active] 1091494000329 potential glutamine specificity residues [chemical binding]; other site 1091494000330 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1091494000331 ATP Binding subdomain [chemical binding]; other site 1091494000332 Ligand Binding sites [chemical binding]; other site 1091494000333 Dimerization subdomain; other site 1091494000334 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091494000335 nucleoside/Zn binding site; other site 1091494000336 dimer interface [polypeptide binding]; other site 1091494000337 catalytic motif [active] 1091494000338 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1091494000339 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1091494000340 active site 1091494000341 dimer interface [polypeptide binding]; other site 1091494000342 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1091494000343 dimer interface [polypeptide binding]; other site 1091494000344 active site 1091494000345 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494000346 Predicted membrane protein [Function unknown]; Region: COG1238 1091494000347 YceI-like domain; Region: YceI; pfam04264 1091494000348 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1091494000349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494000350 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1091494000351 Walker A/P-loop; other site 1091494000352 ATP binding site [chemical binding]; other site 1091494000353 Q-loop/lid; other site 1091494000354 ABC transporter signature motif; other site 1091494000355 Walker B; other site 1091494000356 D-loop; other site 1091494000357 H-loop/switch region; other site 1091494000358 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091494000359 Permease; Region: Permease; pfam02405 1091494000360 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1091494000361 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1091494000362 Walker A/P-loop; other site 1091494000363 ATP binding site [chemical binding]; other site 1091494000364 Q-loop/lid; other site 1091494000365 ABC transporter signature motif; other site 1091494000366 Walker B; other site 1091494000367 D-loop; other site 1091494000368 H-loop/switch region; other site 1091494000369 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1091494000370 mce related protein; Region: MCE; pfam02470 1091494000371 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1091494000372 Cu(I) binding site [ion binding]; other site 1091494000373 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1091494000374 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1091494000375 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1091494000376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494000377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494000378 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1091494000379 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494000380 catalytic residue [active] 1091494000381 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1091494000382 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1091494000383 Walker A motif; other site 1091494000384 ATP binding site [chemical binding]; other site 1091494000385 Walker B motif; other site 1091494000386 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1091494000387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494000388 ATP binding site [chemical binding]; other site 1091494000389 Walker B motif; other site 1091494000390 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1091494000391 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1091494000392 putative metal binding site [ion binding]; other site 1091494000393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494000394 HSP70 interaction site [polypeptide binding]; other site 1091494000395 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1091494000396 ATP binding site [chemical binding]; other site 1091494000397 active site 1091494000398 substrate binding site [chemical binding]; other site 1091494000399 hypothetical protein; Reviewed; Region: PRK00024 1091494000400 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1091494000401 MPN+ (JAMM) motif; other site 1091494000402 Zinc-binding site [ion binding]; other site 1091494000403 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 1091494000404 Flavoprotein; Region: Flavoprotein; pfam02441 1091494000405 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1091494000406 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1091494000407 trimer interface [polypeptide binding]; other site 1091494000408 active site 1091494000409 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1091494000410 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1091494000411 active site 1091494000412 substrate binding site [chemical binding]; other site 1091494000413 metal binding site [ion binding]; metal-binding site 1091494000414 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1091494000415 feedback inhibition sensing region; other site 1091494000416 homohexameric interface [polypeptide binding]; other site 1091494000417 nucleotide binding site [chemical binding]; other site 1091494000418 N-acetyl-L-glutamate binding site [chemical binding]; other site 1091494000419 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1091494000420 YGGT family; Region: YGGT; pfam02325 1091494000421 YGGT family; Region: YGGT; pfam02325 1091494000422 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1091494000423 pyrroline-5-carboxylate reductase; Region: PLN02688 1091494000424 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1091494000425 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1091494000426 classical (c) SDRs; Region: SDR_c; cd05233 1091494000427 NAD(P) binding site [chemical binding]; other site 1091494000428 active site 1091494000429 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1091494000430 Predicted methyltransferase [General function prediction only]; Region: COG4798 1091494000431 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494000432 primosome assembly protein PriA; Validated; Region: PRK05580 1091494000433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494000434 ATP binding site [chemical binding]; other site 1091494000435 putative Mg++ binding site [ion binding]; other site 1091494000436 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1091494000437 nucleotide binding region [chemical binding]; other site 1091494000438 ATP-binding site [chemical binding]; other site 1091494000439 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1091494000440 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1091494000441 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091494000442 active site 1091494000443 HIGH motif; other site 1091494000444 nucleotide binding site [chemical binding]; other site 1091494000445 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1091494000446 KMSK motif region; other site 1091494000447 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1091494000448 tRNA binding surface [nucleotide binding]; other site 1091494000449 anticodon binding site; other site 1091494000450 Sporulation related domain; Region: SPOR; cl10051 1091494000451 Evidence 7 : Gene remnant 1091494000452 Evidence 7 : Gene remnant 1091494000453 Evidence 7 : Gene remnant 1091494000454 Evidence 7 : Gene remnant 1091494000455 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1091494000456 active site 1091494000457 ribulose/triose binding site [chemical binding]; other site 1091494000458 phosphate binding site [ion binding]; other site 1091494000459 substrate (anthranilate) binding pocket [chemical binding]; other site 1091494000460 product (indole) binding pocket [chemical binding]; other site 1091494000461 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1091494000462 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091494000463 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1091494000464 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1091494000465 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1091494000466 glutamine binding [chemical binding]; other site 1091494000467 catalytic triad [active] 1091494000468 anthranilate synthase component I; Provisional; Region: PRK13565 1091494000469 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1091494000470 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1091494000471 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1091494000472 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1091494000473 sensor protein QseC; Provisional; Region: PRK10337 1091494000474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1091494000475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494000476 dimer interface [polypeptide binding]; other site 1091494000477 phosphorylation site [posttranslational modification] 1091494000478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494000479 ATP binding site [chemical binding]; other site 1091494000480 Mg2+ binding site [ion binding]; other site 1091494000481 G-X-G motif; other site 1091494000482 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1091494000483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494000484 active site 1091494000485 phosphorylation site [posttranslational modification] 1091494000486 intermolecular recognition site; other site 1091494000487 dimerization interface [polypeptide binding]; other site 1091494000488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494000489 DNA binding site [nucleotide binding] 1091494000490 HemN family oxidoreductase; Provisional; Region: PRK05660 1091494000491 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494000492 FeS/SAM binding site; other site 1091494000493 HemN C-terminal domain; Region: HemN_C; pfam06969 1091494000494 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494000495 active site 1091494000496 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091494000497 Dynamin family; Region: Dynamin_N; pfam00350 1091494000498 G1 box; other site 1091494000499 GTP/Mg2+ binding site [chemical binding]; other site 1091494000500 G2 box; other site 1091494000501 Switch I region; other site 1091494000502 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1091494000503 G3 box; other site 1091494000504 Switch II region; other site 1091494000505 GTP/Mg2+ binding site [chemical binding]; other site 1091494000506 G4 box; other site 1091494000507 G5 box; other site 1091494000508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494000509 S-adenosylmethionine binding site [chemical binding]; other site 1091494000510 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 1091494000511 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1091494000512 thiS-thiF/thiG interaction site; other site 1091494000513 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1091494000514 ThiS interaction site; other site 1091494000515 putative active site [active] 1091494000516 tetramer interface [polypeptide binding]; other site 1091494000517 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1091494000518 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1091494000519 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1091494000520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494000521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494000522 Walker A/P-loop; other site 1091494000523 ATP binding site [chemical binding]; other site 1091494000524 Q-loop/lid; other site 1091494000525 ABC transporter signature motif; other site 1091494000526 Walker B; other site 1091494000527 D-loop; other site 1091494000528 H-loop/switch region; other site 1091494000529 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1091494000530 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1091494000531 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1091494000532 hypothetical protein; Provisional; Region: PRK00967 1091494000533 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1091494000534 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091494000535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091494000536 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091494000537 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1091494000538 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091494000539 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091494000540 metal-binding site [ion binding] 1091494000541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494000542 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091494000543 Family description; Region: DsbD_2; pfam13386 1091494000544 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091494000545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091494000546 putative acyl-acceptor binding pocket; other site 1091494000547 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1091494000548 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 1091494000549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494000550 S-adenosylmethionine binding site [chemical binding]; other site 1091494000551 Evidence 6 : Doubtful CDS 1091494000552 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1091494000553 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 96094287, 99328963, 99448397; Product type t : transporter 1091494000554 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 96094287, 99328963, 99448397; Product type t : transporter 1091494000555 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1091494000556 potential frameshift: common BLAST hit: gi|333982446|ref|YP_004511656.1| family 2 glycosyl transferase 1091494000557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091494000558 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1091494000559 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1091494000560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091494000561 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1091494000562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091494000563 active site 1091494000564 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1091494000565 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494000566 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1091494000567 active site 1091494000568 DNA binding site [nucleotide binding] 1091494000569 Int/Topo IB signature motif; other site 1091494000570 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091494000571 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 1091494000572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494000573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091494000574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494000575 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494000576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1091494000577 DNA binding residues [nucleotide binding] 1091494000578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091494000579 Integrase core domain; Region: rve; pfam00665 1091494000580 transposase; Provisional; Region: PRK06526 1091494000581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494000582 Walker A motif; other site 1091494000583 ATP binding site [chemical binding]; other site 1091494000584 Walker B motif; other site 1091494000585 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 1091494000586 Evidence 4 : Homologs of previously reported genes of unknown function 1091494000587 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1091494000588 Antitoxin ParD; Region: ParD; pfam09386 1091494000589 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1091494000590 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1091494000591 catalytic residues [active] 1091494000592 catalytic nucleophile [active] 1091494000593 Presynaptic Site I dimer interface [polypeptide binding]; other site 1091494000594 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1091494000595 Synaptic Flat tetramer interface [polypeptide binding]; other site 1091494000596 Synaptic Site I dimer interface [polypeptide binding]; other site 1091494000597 DNA binding site [nucleotide binding] 1091494000598 Part of AAA domain; Region: AAA_19; pfam13245 1091494000599 Family description; Region: UvrD_C_2; pfam13538 1091494000600 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1091494000601 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1091494000602 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1091494000603 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1091494000604 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1091494000605 catalytic motif [active] 1091494000606 Catalytic residue [active] 1091494000607 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1091494000608 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1091494000609 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1091494000610 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1091494000611 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1091494000612 molybdopterin cofactor binding site; other site 1091494000613 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1091494000614 molybdopterin cofactor binding site; other site 1091494000615 PBP superfamily domain; Region: PBP_like; pfam12727 1091494000616 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1091494000617 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1091494000618 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 1091494000619 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1091494000620 Outer membrane efflux protein; Region: OEP; pfam02321 1091494000621 Outer membrane efflux protein; Region: OEP; pfam02321 1091494000622 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091494000623 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1091494000624 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494000625 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494000626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494000627 Walker A/P-loop; other site 1091494000628 ATP binding site [chemical binding]; other site 1091494000629 ABC transporter; Region: ABC_tran; pfam00005 1091494000630 Q-loop/lid; other site 1091494000631 ABC transporter signature motif; other site 1091494000632 Walker B; other site 1091494000633 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1091494000634 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1091494000635 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1091494000636 Walker A motif; other site 1091494000637 ATP binding site [chemical binding]; other site 1091494000638 Walker B motif; other site 1091494000639 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091494000640 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1091494000641 dimer interface [polypeptide binding]; other site 1091494000642 substrate binding site [chemical binding]; other site 1091494000643 metal binding sites [ion binding]; metal-binding site 1091494000644 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1091494000645 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091494000646 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1091494000647 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1091494000648 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1091494000649 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1091494000650 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1091494000651 active site 1091494000652 Zn binding site [ion binding]; other site 1091494000653 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091494000654 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1091494000655 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091494000656 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1091494000657 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091494000658 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1091494000659 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1091494000660 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1091494000661 dimer interface [polypeptide binding]; other site 1091494000662 active site residues [active] 1091494000663 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1091494000664 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1091494000665 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 1091494000666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494000667 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1091494000668 substrate binding site [chemical binding]; other site 1091494000669 dimerization interface [polypeptide binding]; other site 1091494000670 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1091494000671 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1091494000672 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091494000673 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1091494000674 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1091494000675 Walker A/P-loop; other site 1091494000676 ATP binding site [chemical binding]; other site 1091494000677 Q-loop/lid; other site 1091494000678 ABC transporter signature motif; other site 1091494000679 Walker B; other site 1091494000680 D-loop; other site 1091494000681 H-loop/switch region; other site 1091494000682 sulfate transport protein; Provisional; Region: cysT; CHL00187 1091494000683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494000684 dimer interface [polypeptide binding]; other site 1091494000685 conserved gate region; other site 1091494000686 putative PBP binding loops; other site 1091494000687 ABC-ATPase subunit interface; other site 1091494000688 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1091494000689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494000690 dimer interface [polypeptide binding]; other site 1091494000691 conserved gate region; other site 1091494000692 putative PBP binding loops; other site 1091494000693 ABC-ATPase subunit interface; other site 1091494000694 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1091494000695 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091494000696 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1091494000697 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 1091494000698 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1091494000699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091494000700 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1091494000701 active site 1091494000702 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1091494000703 AMP-binding enzyme; Region: AMP-binding; pfam00501 1091494000704 acyl-activating enzyme (AAE) consensus motif; other site 1091494000705 AMP binding site [chemical binding]; other site 1091494000706 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1091494000707 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1091494000708 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091494000709 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1091494000710 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091494000711 dimer interface [polypeptide binding]; other site 1091494000712 active site 1091494000713 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1091494000714 putative active site 1 [active] 1091494000715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1091494000716 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1091494000717 NAD(P) binding site [chemical binding]; other site 1091494000718 homotetramer interface [polypeptide binding]; other site 1091494000719 homodimer interface [polypeptide binding]; other site 1091494000720 active site 1091494000721 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1091494000722 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091494000723 dimer interface [polypeptide binding]; other site 1091494000724 active site 1091494000725 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1091494000726 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1091494000727 putative substrate binding site [chemical binding]; other site 1091494000728 putative ATP binding site [chemical binding]; other site 1091494000729 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1091494000730 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1091494000731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494000732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494000733 metal binding site [ion binding]; metal-binding site 1091494000734 active site 1091494000735 I-site; other site 1091494000736 Protein of unknown function DUF72; Region: DUF72; cl00777 1091494000737 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1091494000738 hypothetical protein; Reviewed; Region: PRK09588 1091494000739 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1091494000740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091494000741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494000742 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1091494000743 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1091494000744 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1091494000745 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1091494000746 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1091494000747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1091494000748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494000749 substrate binding pocket [chemical binding]; other site 1091494000750 membrane-bound complex binding site; other site 1091494000751 hinge residues; other site 1091494000752 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1091494000753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494000754 Zn2+ binding site [ion binding]; other site 1091494000755 Mg2+ binding site [ion binding]; other site 1091494000756 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1091494000757 Rubrerythrin [Energy production and conversion]; Region: COG1592 1091494000758 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1091494000759 iron binding site [ion binding]; other site 1091494000760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091494000761 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1091494000762 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1091494000763 Class II fumarases; Region: Fumarase_classII; cd01362 1091494000764 active site 1091494000765 tetramer interface [polypeptide binding]; other site 1091494000766 Ferritin-like domain; Region: Ferritin; pfam00210 1091494000767 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1091494000768 dinuclear metal binding motif [ion binding]; other site 1091494000769 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1091494000770 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1091494000771 active site 1091494000772 substrate binding site [chemical binding]; other site 1091494000773 Mg2+ binding site [ion binding]; other site 1091494000774 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1091494000775 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1091494000776 putative active site [active] 1091494000777 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177 1091494000778 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1091494000779 TPP-binding site [chemical binding]; other site 1091494000780 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1091494000781 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1091494000782 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1091494000783 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1091494000784 dimer interface [polypeptide binding]; other site 1091494000785 PYR/PP interface [polypeptide binding]; other site 1091494000786 TPP binding site [chemical binding]; other site 1091494000787 substrate binding site [chemical binding]; other site 1091494000788 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1091494000789 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1091494000790 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494000791 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 1091494000792 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1091494000793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494000794 non-specific DNA binding site [nucleotide binding]; other site 1091494000795 salt bridge; other site 1091494000796 sequence-specific DNA binding site [nucleotide binding]; other site 1091494000797 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1091494000798 TSCPD domain; Region: TSCPD; pfam12637 1091494000799 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1091494000800 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1091494000801 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1091494000802 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1091494000803 protein-splicing catalytic site; other site 1091494000804 thioester formation/cholesterol transfer; other site 1091494000805 Homing endonuclease; Region: Hom_end; pfam05204 1091494000806 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1091494000807 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1091494000808 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1091494000809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494000810 ATP binding site [chemical binding]; other site 1091494000811 putative Mg++ binding site [ion binding]; other site 1091494000812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494000813 nucleotide binding region [chemical binding]; other site 1091494000814 ATP-binding site [chemical binding]; other site 1091494000815 Double zinc ribbon; Region: DZR; pfam12773 1091494000816 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1091494000817 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1091494000818 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1091494000819 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091494000820 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1091494000821 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1091494000822 Membrane fusogenic activity; Region: BMFP; pfam04380 1091494000823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091494000824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494000825 putative DNA binding site [nucleotide binding]; other site 1091494000826 putative Zn2+ binding site [ion binding]; other site 1091494000827 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1091494000828 aconitate hydratase; Validated; Region: PRK09277 1091494000829 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1091494000830 substrate binding site [chemical binding]; other site 1091494000831 ligand binding site [chemical binding]; other site 1091494000832 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1091494000833 substrate binding site [chemical binding]; other site 1091494000834 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1091494000835 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494000836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494000837 motif II; other site 1091494000838 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1091494000839 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1091494000840 CreA protein; Region: CreA; pfam05981 1091494000841 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1091494000842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494000843 Walker A motif; other site 1091494000844 ATP binding site [chemical binding]; other site 1091494000845 Walker B motif; other site 1091494000846 arginine finger; other site 1091494000847 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494000848 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1091494000849 active site clefts [active] 1091494000850 zinc binding site [ion binding]; other site 1091494000851 dimer interface [polypeptide binding]; other site 1091494000852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1091494000853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091494000854 Coenzyme A binding pocket [chemical binding]; other site 1091494000855 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1091494000856 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091494000857 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091494000858 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1091494000859 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091494000860 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091494000861 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091494000862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1091494000863 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1091494000864 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1091494000865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494000866 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1091494000867 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1091494000868 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1091494000869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494000870 S-adenosylmethionine binding site [chemical binding]; other site 1091494000871 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091494000872 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494000873 P-loop; other site 1091494000874 Magnesium ion binding site [ion binding]; other site 1091494000875 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1091494000876 ParB-like nuclease domain; Region: ParBc; pfam02195 1091494000877 ATP synthase I chain; Region: ATP_synt_I; cl09170 1091494000878 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1091494000879 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1091494000880 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1091494000881 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1091494000882 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1091494000883 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1091494000884 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1091494000885 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1091494000886 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494000887 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1091494000888 beta subunit interaction interface [polypeptide binding]; other site 1091494000889 Walker A motif; other site 1091494000890 ATP binding site [chemical binding]; other site 1091494000891 Walker B motif; other site 1091494000892 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091494000893 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1091494000894 core domain interface [polypeptide binding]; other site 1091494000895 delta subunit interface [polypeptide binding]; other site 1091494000896 epsilon subunit interface [polypeptide binding]; other site 1091494000897 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1091494000898 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494000899 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1091494000900 alpha subunit interaction interface [polypeptide binding]; other site 1091494000901 Walker A motif; other site 1091494000902 ATP binding site [chemical binding]; other site 1091494000903 Walker B motif; other site 1091494000904 inhibitor binding site; inhibition site 1091494000905 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091494000906 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1091494000907 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1091494000908 gamma subunit interface [polypeptide binding]; other site 1091494000909 epsilon subunit interface [polypeptide binding]; other site 1091494000910 LBP interface [polypeptide binding]; other site 1091494000911 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1091494000912 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1091494000913 Substrate binding site; other site 1091494000914 Mg++ binding site; other site 1091494000915 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1091494000916 active site 1091494000917 substrate binding site [chemical binding]; other site 1091494000918 CoA binding site [chemical binding]; other site 1091494000919 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1091494000920 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1091494000921 glutaminase active site [active] 1091494000922 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1091494000923 dimer interface [polypeptide binding]; other site 1091494000924 active site 1091494000925 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1091494000926 dimer interface [polypeptide binding]; other site 1091494000927 active site 1091494000928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494000929 non-specific DNA binding site [nucleotide binding]; other site 1091494000930 salt bridge; other site 1091494000931 sequence-specific DNA binding site [nucleotide binding]; other site 1091494000932 Helix-turn-helix domain; Region: HTH_17; pfam12728 1091494000933 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1091494000934 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1091494000935 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1091494000936 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494000937 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1091494000938 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1091494000939 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091494000940 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1091494000941 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1091494000942 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 1091494000943 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1091494000944 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494000945 active site residue [active] 1091494000946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494000947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494000948 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1091494000949 Cytochrome C' Region: Cytochrom_C_2; cl01610 1091494000950 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091494000951 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494000952 Walker A/P-loop; other site 1091494000953 ATP binding site [chemical binding]; other site 1091494000954 Q-loop/lid; other site 1091494000955 ABC transporter signature motif; other site 1091494000956 Walker B; other site 1091494000957 D-loop; other site 1091494000958 H-loop/switch region; other site 1091494000959 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494000960 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1091494000961 FtsX-like permease family; Region: FtsX; pfam02687 1091494000962 HlyD family secretion protein; Region: HlyD_2; pfam12700 1091494000963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494000964 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494000965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494000966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494000967 NlpE N-terminal domain; Region: NlpE; pfam04170 1091494000968 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 1091494000969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494000970 S-adenosylmethionine binding site [chemical binding]; other site 1091494000971 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1091494000972 Isochorismatase family; Region: Isochorismatase; pfam00857 1091494000973 catalytic triad [active] 1091494000974 metal binding site [ion binding]; metal-binding site 1091494000975 conserved cis-peptide bond; other site 1091494000976 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1091494000977 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1091494000978 active site 1091494000979 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 1091494000980 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1091494000981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494000982 ATP binding site [chemical binding]; other site 1091494000983 putative Mg++ binding site [ion binding]; other site 1091494000984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494000985 nucleotide binding region [chemical binding]; other site 1091494000986 ATP-binding site [chemical binding]; other site 1091494000987 DEAD/H associated; Region: DEAD_assoc; pfam08494 1091494000988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1091494000989 Smr domain; Region: Smr; pfam01713 1091494000990 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1091494000991 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1091494000992 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091494000993 ATP binding site [chemical binding]; other site 1091494000994 Mg++ binding site [ion binding]; other site 1091494000995 motif III; other site 1091494000996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494000997 nucleotide binding region [chemical binding]; other site 1091494000998 ATP-binding site [chemical binding]; other site 1091494000999 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1091494001000 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1091494001001 catalytic site [active] 1091494001002 G-X2-G-X-G-K; other site 1091494001003 Phosphotransferase enzyme family; Region: APH; pfam01636 1091494001004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1091494001005 active site 1091494001006 substrate binding site [chemical binding]; other site 1091494001007 ATP binding site [chemical binding]; other site 1091494001008 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1091494001009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494001010 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1091494001011 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 1091494001012 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1091494001013 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1091494001014 DNA photolyase; Region: DNA_photolyase; pfam00875 1091494001015 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1091494001016 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1091494001017 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1091494001018 putative hydrophobic ligand binding site [chemical binding]; other site 1091494001019 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 1091494001020 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1091494001021 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1091494001022 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1091494001023 EamA-like transporter family; Region: EamA; pfam00892 1091494001024 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1091494001025 EamA-like transporter family; Region: EamA; pfam00892 1091494001026 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1091494001027 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1091494001028 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091494001029 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091494001030 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1091494001031 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1091494001032 HD domain; Region: HD_4; pfam13328 1091494001033 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1091494001034 synthetase active site [active] 1091494001035 NTP binding site [chemical binding]; other site 1091494001036 metal binding site [ion binding]; metal-binding site 1091494001037 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1091494001038 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1091494001039 DNA polymerase I; Provisional; Region: PRK05755 1091494001040 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1091494001041 active site 1091494001042 metal binding site 1 [ion binding]; metal-binding site 1091494001043 putative 5' ssDNA interaction site; other site 1091494001044 metal binding site 3; metal-binding site 1091494001045 metal binding site 2 [ion binding]; metal-binding site 1091494001046 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1091494001047 putative DNA binding site [nucleotide binding]; other site 1091494001048 putative metal binding site [ion binding]; other site 1091494001049 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1091494001050 active site 1091494001051 catalytic site [active] 1091494001052 substrate binding site [chemical binding]; other site 1091494001053 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1091494001054 active site 1091494001055 DNA binding site [nucleotide binding] 1091494001056 catalytic site [active] 1091494001057 HDOD domain; Region: HDOD; pfam08668 1091494001058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494001059 Zn2+ binding site [ion binding]; other site 1091494001060 Mg2+ binding site [ion binding]; other site 1091494001061 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1091494001062 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1091494001063 G1 box; other site 1091494001064 GTP/Mg2+ binding site [chemical binding]; other site 1091494001065 Switch I region; other site 1091494001066 G2 box; other site 1091494001067 G3 box; other site 1091494001068 Switch II region; other site 1091494001069 G4 box; other site 1091494001070 G5 box; other site 1091494001071 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1091494001072 Cytochrome c; Region: Cytochrom_C; cl11414 1091494001073 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1091494001074 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091494001075 catalytic residues [active] 1091494001076 hinge region; other site 1091494001077 alpha helical domain; other site 1091494001078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494001079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494001080 metal binding site [ion binding]; metal-binding site 1091494001081 active site 1091494001082 I-site; other site 1091494001083 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1091494001084 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1091494001085 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1091494001086 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1091494001087 generic binding surface II; other site 1091494001088 generic binding surface I; other site 1091494001089 Flagellar regulator YcgR; Region: YcgR; pfam07317 1091494001090 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1091494001091 PilZ domain; Region: PilZ; pfam07238 1091494001092 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1091494001093 DsrH like protein; Region: DsrH; cl17347 1091494001094 DsrC like protein; Region: DsrC; pfam04358 1091494001095 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1091494001096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091494001097 RNA binding surface [nucleotide binding]; other site 1091494001098 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494001099 active site residue [active] 1091494001100 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091494001101 TrkA-N domain; Region: TrkA_N; pfam02254 1091494001102 TrkA-N domain; Region: TrkA_N; pfam02254 1091494001103 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1091494001104 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1091494001105 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1091494001106 putative protease; Provisional; Region: PRK15452 1091494001107 Peptidase family U32; Region: Peptidase_U32; pfam01136 1091494001108 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1091494001109 putative active site [active] 1091494001110 dimerization interface [polypeptide binding]; other site 1091494001111 putative tRNAtyr binding site [nucleotide binding]; other site 1091494001112 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1091494001113 Staphylococcal nuclease homologues; Region: SNc; smart00318 1091494001114 Catalytic site; other site 1091494001115 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1091494001116 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1091494001117 hypothetical protein; Provisional; Region: PRK05409 1091494001118 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1091494001119 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1091494001120 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091494001121 minor groove reading motif; other site 1091494001122 helix-hairpin-helix signature motif; other site 1091494001123 substrate binding pocket [chemical binding]; other site 1091494001124 active site 1091494001125 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1091494001126 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1091494001127 FMN-binding domain; Region: FMN_bind; cl01081 1091494001128 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1091494001129 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1091494001130 SLBB domain; Region: SLBB; pfam10531 1091494001131 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091494001132 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 1091494001133 Putative Fe-S cluster; Region: FeS; pfam04060 1091494001134 4Fe-4S binding domain; Region: Fer4; pfam00037 1091494001135 electron transport complex protein RsxA; Provisional; Region: PRK05151 1091494001136 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494001137 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494001138 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091494001139 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1091494001140 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1091494001141 active site clefts [active] 1091494001142 zinc binding site [ion binding]; other site 1091494001143 dimer interface [polypeptide binding]; other site 1091494001144 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1091494001145 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1091494001146 NADP-binding site; other site 1091494001147 homotetramer interface [polypeptide binding]; other site 1091494001148 substrate binding site [chemical binding]; other site 1091494001149 homodimer interface [polypeptide binding]; other site 1091494001150 active site 1091494001151 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1091494001152 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1091494001153 NADP binding site [chemical binding]; other site 1091494001154 active site 1091494001155 putative substrate binding site [chemical binding]; other site 1091494001156 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1091494001157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091494001158 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1091494001159 SEC-C motif; Region: SEC-C; pfam02810 1091494001160 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1091494001161 homodimer interface [polypeptide binding]; other site 1091494001162 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1091494001163 active site pocket [active] 1091494001164 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1091494001165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1091494001166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494001167 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1091494001168 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1091494001169 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1091494001170 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1091494001171 preprotein translocase subunit SecB; Validated; Region: PRK05751 1091494001172 SecA binding site; other site 1091494001173 Preprotein binding site; other site 1091494001174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494001175 active site residue [active] 1091494001176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494001177 dimerization interface [polypeptide binding]; other site 1091494001178 putative DNA binding site [nucleotide binding]; other site 1091494001179 putative Zn2+ binding site [ion binding]; other site 1091494001180 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1091494001181 Peptidase family M23; Region: Peptidase_M23; pfam01551 1091494001182 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1091494001183 C-terminal peptidase (prc); Region: prc; TIGR00225 1091494001184 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1091494001185 protein binding site [polypeptide binding]; other site 1091494001186 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1091494001187 Catalytic dyad [active] 1091494001188 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1091494001189 NodB motif; other site 1091494001190 putative active site [active] 1091494001191 putative catalytic site [active] 1091494001192 Zn binding site [ion binding]; other site 1091494001193 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1091494001194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494001195 putative active site [active] 1091494001196 heme pocket [chemical binding]; other site 1091494001197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494001198 PAS domain; Region: PAS_9; pfam13426 1091494001199 putative active site [active] 1091494001200 heme pocket [chemical binding]; other site 1091494001201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494001202 putative active site [active] 1091494001203 heme pocket [chemical binding]; other site 1091494001204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494001205 dimer interface [polypeptide binding]; other site 1091494001206 phosphorylation site [posttranslational modification] 1091494001207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494001208 ATP binding site [chemical binding]; other site 1091494001209 Mg2+ binding site [ion binding]; other site 1091494001210 G-X-G motif; other site 1091494001211 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494001212 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494001213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494001214 active site 1091494001215 phosphorylation site [posttranslational modification] 1091494001216 intermolecular recognition site; other site 1091494001217 dimerization interface [polypeptide binding]; other site 1091494001218 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494001219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494001220 active site 1091494001221 phosphorylation site [posttranslational modification] 1091494001222 intermolecular recognition site; other site 1091494001223 dimerization interface [polypeptide binding]; other site 1091494001224 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494001225 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494001226 metal binding site [ion binding]; metal-binding site 1091494001227 active site 1091494001228 I-site; other site 1091494001229 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1091494001230 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1091494001231 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1091494001232 RibD C-terminal domain; Region: RibD_C; cl17279 1091494001233 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 1091494001234 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494001235 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494001236 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1091494001237 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494001238 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1091494001239 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1091494001240 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1091494001241 active site 1091494001242 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1091494001243 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1091494001244 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1091494001245 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1091494001246 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1091494001247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1091494001248 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1091494001249 substrate binding site [chemical binding]; other site 1091494001250 oxyanion hole (OAH) forming residues; other site 1091494001251 trimer interface [polypeptide binding]; other site 1091494001252 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1091494001253 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1091494001254 dimer interface [polypeptide binding]; other site 1091494001255 active site 1091494001256 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1091494001257 putative acyl-acceptor binding pocket; other site 1091494001258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091494001259 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1091494001260 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494001261 Walker A motif; other site 1091494001262 ATP binding site [chemical binding]; other site 1091494001263 Walker B motif; other site 1091494001264 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1091494001265 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1091494001266 Ligand Binding Site [chemical binding]; other site 1091494001267 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1091494001268 CPxP motif; other site 1091494001269 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1091494001270 Cation efflux family; Region: Cation_efflux; cl00316 1091494001271 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1091494001272 heterotetramer interface [polypeptide binding]; other site 1091494001273 active site pocket [active] 1091494001274 cleavage site 1091494001275 hypothetical protein; Provisional; Region: PRK08999 1091494001276 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1091494001277 active site 1091494001278 8-oxo-dGMP binding site [chemical binding]; other site 1091494001279 nudix motif; other site 1091494001280 metal binding site [ion binding]; metal-binding site 1091494001281 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1091494001282 thiamine phosphate binding site [chemical binding]; other site 1091494001283 active site 1091494001284 pyrophosphate binding site [ion binding]; other site 1091494001285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091494001286 catalytic residues [active] 1091494001287 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1091494001288 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1091494001289 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1091494001290 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 1091494001291 non-specific DNA binding site [nucleotide binding]; other site 1091494001292 salt bridge; other site 1091494001293 sequence-specific DNA binding site [nucleotide binding]; other site 1091494001294 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1091494001295 PilZ domain; Region: PilZ; pfam07238 1091494001296 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1091494001297 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1091494001298 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494001299 Walker A motif; other site 1091494001300 ATP binding site [chemical binding]; other site 1091494001301 Walker B motif; other site 1091494001302 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1091494001303 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494001304 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494001305 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1091494001306 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 1091494001307 Autotransporter beta-domain; Region: Autotransporter; smart00869 1091494001308 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1091494001309 putative active site [active] 1091494001310 putative catalytic triad [active] 1091494001311 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1091494001312 catalytic residues [active] 1091494001313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1091494001314 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091494001315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494001316 Walker A motif; other site 1091494001317 ATP binding site [chemical binding]; other site 1091494001318 Walker B motif; other site 1091494001319 arginine finger; other site 1091494001320 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091494001321 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1091494001322 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091494001323 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091494001324 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1091494001325 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1091494001326 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1091494001327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1091494001328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1091494001329 active site 1091494001330 catalytic tetrad [active] 1091494001331 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 1091494001332 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1091494001333 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1091494001334 putative cation:proton antiport protein; Provisional; Region: PRK10669 1091494001335 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091494001336 TrkA-N domain; Region: TrkA_N; pfam02254 1091494001337 TrkA-C domain; Region: TrkA_C; pfam02080 1091494001338 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1091494001339 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1091494001340 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1091494001341 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1091494001342 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1091494001343 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1091494001344 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1091494001345 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1091494001346 Protein export membrane protein; Region: SecD_SecF; pfam02355 1091494001347 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494001348 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494001349 Integrase core domain; Region: rve; pfam00665 1091494001350 Integrase core domain; Region: rve_3; pfam13683 1091494001351 Transposase; Region: HTH_Tnp_1; cl17663 1091494001352 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1091494001353 active site 1091494001354 multimer interface [polypeptide binding]; other site 1091494001355 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1091494001356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494001357 FeS/SAM binding site; other site 1091494001358 TPR repeat; Region: TPR_11; pfam13414 1091494001359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494001360 binding surface 1091494001361 TPR motif; other site 1091494001362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494001363 binding surface 1091494001364 TPR motif; other site 1091494001365 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1091494001366 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1091494001367 dimer interface [polypeptide binding]; other site 1091494001368 motif 1; other site 1091494001369 active site 1091494001370 motif 2; other site 1091494001371 motif 3; other site 1091494001372 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1091494001373 anticodon binding site; other site 1091494001374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1091494001375 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1091494001376 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1091494001377 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1091494001378 Trp docking motif [polypeptide binding]; other site 1091494001379 active site 1091494001380 GTP-binding protein Der; Reviewed; Region: PRK00093 1091494001381 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1091494001382 G1 box; other site 1091494001383 GTP/Mg2+ binding site [chemical binding]; other site 1091494001384 Switch I region; other site 1091494001385 G2 box; other site 1091494001386 Switch II region; other site 1091494001387 G3 box; other site 1091494001388 G4 box; other site 1091494001389 G5 box; other site 1091494001390 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1091494001391 G1 box; other site 1091494001392 GTP/Mg2+ binding site [chemical binding]; other site 1091494001393 Switch I region; other site 1091494001394 G2 box; other site 1091494001395 G3 box; other site 1091494001396 Switch II region; other site 1091494001397 G4 box; other site 1091494001398 G5 box; other site 1091494001399 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1091494001400 heme-binding site [chemical binding]; other site 1091494001401 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494001402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494001403 putative active site [active] 1091494001404 heme pocket [chemical binding]; other site 1091494001405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494001406 dimer interface [polypeptide binding]; other site 1091494001407 phosphorylation site [posttranslational modification] 1091494001408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494001409 ATP binding site [chemical binding]; other site 1091494001410 Mg2+ binding site [ion binding]; other site 1091494001411 G-X-G motif; other site 1091494001412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494001413 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494001414 active site 1091494001415 phosphorylation site [posttranslational modification] 1091494001416 intermolecular recognition site; other site 1091494001417 dimerization interface [polypeptide binding]; other site 1091494001418 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494001419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494001420 active site 1091494001421 phosphorylation site [posttranslational modification] 1091494001422 intermolecular recognition site; other site 1091494001423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494001424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494001425 metal binding site [ion binding]; metal-binding site 1091494001426 active site 1091494001427 I-site; other site 1091494001428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494001429 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494001430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494001431 active site 1091494001432 phosphorylation site [posttranslational modification] 1091494001433 intermolecular recognition site; other site 1091494001434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494001435 PAS domain; Region: PAS_9; pfam13426 1091494001436 putative active site [active] 1091494001437 heme pocket [chemical binding]; other site 1091494001438 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494001439 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494001440 metal binding site [ion binding]; metal-binding site 1091494001441 active site 1091494001442 I-site; other site 1091494001443 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494001444 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1091494001445 Protein of unknown function, DUF; Region: DUF411; cl01142 1091494001446 Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829 1091494001447 Ammonia monooxygenase; Region: AMO; pfam02461 1091494001448 methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079 1091494001449 Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744 1091494001450 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1091494001451 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1091494001452 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1091494001453 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1091494001454 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1091494001455 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1091494001456 substrate binding pocket [chemical binding]; other site 1091494001457 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1091494001458 B12 binding site [chemical binding]; other site 1091494001459 cobalt ligand [ion binding]; other site 1091494001460 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1091494001461 hypothetical protein; Provisional; Region: PRK05208 1091494001462 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1091494001463 Cupin domain; Region: Cupin_2; pfam07883 1091494001464 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1091494001465 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1091494001466 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1091494001467 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1091494001468 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1091494001469 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1091494001470 hexamer interface [polypeptide binding]; other site 1091494001471 ligand binding site [chemical binding]; other site 1091494001472 putative active site [active] 1091494001473 NAD(P) binding site [chemical binding]; other site 1091494001474 Septum formation initiator; Region: DivIC; cl17659 1091494001475 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1091494001476 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1091494001477 NAD(P) binding site [chemical binding]; other site 1091494001478 LDH/MDH dimer interface [polypeptide binding]; other site 1091494001479 substrate binding site [chemical binding]; other site 1091494001480 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1091494001481 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1091494001482 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1091494001483 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1091494001484 Walker A/P-loop; other site 1091494001485 ATP binding site [chemical binding]; other site 1091494001486 Q-loop/lid; other site 1091494001487 ABC transporter signature motif; other site 1091494001488 Walker B; other site 1091494001489 D-loop; other site 1091494001490 H-loop/switch region; other site 1091494001491 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1091494001492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494001493 dimer interface [polypeptide binding]; other site 1091494001494 conserved gate region; other site 1091494001495 putative PBP binding loops; other site 1091494001496 ABC-ATPase subunit interface; other site 1091494001497 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1091494001498 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494001499 substrate binding pocket [chemical binding]; other site 1091494001500 membrane-bound complex binding site; other site 1091494001501 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1091494001502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494001503 FeS/SAM binding site; other site 1091494001504 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1091494001505 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1091494001506 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091494001507 ATP binding site [chemical binding]; other site 1091494001508 Mg++ binding site [ion binding]; other site 1091494001509 motif III; other site 1091494001510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494001511 nucleotide binding region [chemical binding]; other site 1091494001512 ATP-binding site [chemical binding]; other site 1091494001513 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1091494001514 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1091494001515 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1091494001516 active site 1091494001517 catalytic residues [active] 1091494001518 metal binding site [ion binding]; metal-binding site 1091494001519 homodimer binding site [polypeptide binding]; other site 1091494001520 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091494001521 carboxyltransferase (CT) interaction site; other site 1091494001522 biotinylation site [posttranslational modification]; other site 1091494001523 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1091494001524 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1091494001525 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494001526 N-terminal plug; other site 1091494001527 ligand-binding site [chemical binding]; other site 1091494001528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1091494001529 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1091494001530 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1091494001531 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1091494001532 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1091494001533 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1091494001534 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091494001535 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1091494001536 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1091494001537 putative peptidase; Provisional; Region: PRK11649 1091494001538 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1091494001539 Peptidase family M23; Region: Peptidase_M23; pfam01551 1091494001540 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1091494001541 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1091494001542 active site 1091494001543 HIGH motif; other site 1091494001544 dimer interface [polypeptide binding]; other site 1091494001545 KMSKS motif; other site 1091494001546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091494001547 RNA binding surface [nucleotide binding]; other site 1091494001548 Evidence 7 : Gene remnant; Product type pr : regulator 1091494001549 Evidence 7 : Gene remnant; Product type pr : regulator 1091494001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494001551 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091494001552 Walker A motif; other site 1091494001553 ATP binding site [chemical binding]; other site 1091494001554 Walker B motif; other site 1091494001555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494001556 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091494001557 Walker A motif; other site 1091494001558 ATP binding site [chemical binding]; other site 1091494001559 Walker B motif; other site 1091494001560 arginine finger; other site 1091494001561 ABC transporter ATPase component; Reviewed; Region: PRK11147 1091494001562 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494001563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494001564 ABC transporter; Region: ABC_tran_2; pfam12848 1091494001565 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494001566 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1091494001567 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1091494001568 putative MPT binding site; other site 1091494001569 Predicted permeases [General function prediction only]; Region: COG0679 1091494001570 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1091494001571 active site 1091494001572 dimer interface [polypeptide binding]; other site 1091494001573 Family description; Region: DsbD_2; pfam13386 1091494001574 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1091494001575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494001576 Walker A motif; other site 1091494001577 ATP binding site [chemical binding]; other site 1091494001578 Walker B motif; other site 1091494001579 arginine finger; other site 1091494001580 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494001581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091494001582 active site 1091494001583 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1091494001584 active site 1091494001585 hydrophilic channel; other site 1091494001586 dimerization interface [polypeptide binding]; other site 1091494001587 catalytic residues [active] 1091494001588 active site lid [active] 1091494001589 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1091494001590 Recombination protein O N terminal; Region: RecO_N; pfam11967 1091494001591 Recombination protein O C terminal; Region: RecO_C; pfam02565 1091494001592 GTPase Era; Reviewed; Region: era; PRK00089 1091494001593 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1091494001594 G1 box; other site 1091494001595 GTP/Mg2+ binding site [chemical binding]; other site 1091494001596 Switch I region; other site 1091494001597 G2 box; other site 1091494001598 Switch II region; other site 1091494001599 G3 box; other site 1091494001600 G4 box; other site 1091494001601 G5 box; other site 1091494001602 KH domain; Region: KH_2; pfam07650 1091494001603 ribonuclease III; Reviewed; Region: rnc; PRK00102 1091494001604 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1091494001605 dimerization interface [polypeptide binding]; other site 1091494001606 active site 1091494001607 metal binding site [ion binding]; metal-binding site 1091494001608 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1091494001609 dsRNA binding site [nucleotide binding]; other site 1091494001610 signal peptidase I; Provisional; Region: PRK10861 1091494001611 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1091494001612 Catalytic site [active] 1091494001613 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1091494001614 GTP-binding protein LepA; Provisional; Region: PRK05433 1091494001615 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1091494001616 G1 box; other site 1091494001617 putative GEF interaction site [polypeptide binding]; other site 1091494001618 GTP/Mg2+ binding site [chemical binding]; other site 1091494001619 Switch I region; other site 1091494001620 G2 box; other site 1091494001621 G3 box; other site 1091494001622 Switch II region; other site 1091494001623 G4 box; other site 1091494001624 G5 box; other site 1091494001625 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1091494001626 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1091494001627 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1091494001628 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1091494001629 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494001630 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494001631 protein binding site [polypeptide binding]; other site 1091494001632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494001633 protein binding site [polypeptide binding]; other site 1091494001634 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1091494001635 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1091494001636 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1091494001637 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1091494001638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494001639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494001640 DNA binding residues [nucleotide binding] 1091494001641 L-aspartate oxidase; Provisional; Region: PRK09077 1091494001642 L-aspartate oxidase; Provisional; Region: PRK06175 1091494001643 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091494001644 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091494001645 G1 box; other site 1091494001646 GTP/Mg2+ binding site [chemical binding]; other site 1091494001647 G2 box; other site 1091494001648 Switch I region; other site 1091494001649 G3 box; other site 1091494001650 Switch II region; other site 1091494001651 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1091494001652 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494001653 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494001654 ligand binding site [chemical binding]; other site 1091494001655 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1091494001656 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1091494001657 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1091494001658 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1091494001659 TAP-like protein; Region: Abhydrolase_4; pfam08386 1091494001660 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1091494001661 Flavoprotein; Region: Flavoprotein; pfam02441 1091494001662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494001663 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494001664 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1091494001665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494001666 FeS/SAM binding site; other site 1091494001667 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1091494001668 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1091494001669 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494001670 putative active site [active] 1091494001671 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1091494001672 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1091494001673 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1091494001674 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1091494001675 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1091494001676 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1091494001677 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1091494001678 quinone interaction residues [chemical binding]; other site 1091494001679 active site 1091494001680 catalytic residues [active] 1091494001681 FMN binding site [chemical binding]; other site 1091494001682 substrate binding site [chemical binding]; other site 1091494001683 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1091494001684 EamA-like transporter family; Region: EamA; cl17759 1091494001685 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1091494001686 active site 1091494001687 substrate binding site [chemical binding]; other site 1091494001688 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1091494001689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494001690 ATP binding site [chemical binding]; other site 1091494001691 putative Mg++ binding site [ion binding]; other site 1091494001692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494001693 nucleotide binding region [chemical binding]; other site 1091494001694 ATP-binding site [chemical binding]; other site 1091494001695 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1091494001696 Part of AAA domain; Region: AAA_19; pfam13245 1091494001697 Family description; Region: UvrD_C_2; pfam13538 1091494001698 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091494001699 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494001700 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1091494001701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494001702 Walker A/P-loop; other site 1091494001703 ATP binding site [chemical binding]; other site 1091494001704 Q-loop/lid; other site 1091494001705 ABC transporter signature motif; other site 1091494001706 Walker B; other site 1091494001707 D-loop; other site 1091494001708 H-loop/switch region; other site 1091494001709 ABC transporter; Region: ABC_tran_2; pfam12848 1091494001710 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494001711 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 1091494001712 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 1091494001713 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1091494001714 putative ADP-binding pocket [chemical binding]; other site 1091494001715 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 1091494001716 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1091494001717 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091494001718 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091494001719 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1091494001720 putative substrate binding site [chemical binding]; other site 1091494001721 putative ATP binding site [chemical binding]; other site 1091494001722 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1091494001723 trehalose synthase; Region: treS_nterm; TIGR02456 1091494001724 active site 1091494001725 catalytic site [active] 1091494001726 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1091494001727 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1091494001728 Walker A/P-loop; other site 1091494001729 ATP binding site [chemical binding]; other site 1091494001730 Q-loop/lid; other site 1091494001731 ABC transporter signature motif; other site 1091494001732 Walker B; other site 1091494001733 D-loop; other site 1091494001734 H-loop/switch region; other site 1091494001735 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1091494001736 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1091494001737 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1091494001738 Ion channel; Region: Ion_trans_2; pfam07885 1091494001739 TrkA-N domain; Region: TrkA_N; pfam02254 1091494001740 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1091494001741 Predicted membrane protein [Function unknown]; Region: COG3766 1091494001742 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1091494001743 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1091494001744 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1091494001745 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1091494001746 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 1091494001747 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1091494001748 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1091494001749 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1091494001750 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091494001751 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1091494001752 dimer interface [polypeptide binding]; other site 1091494001753 N-terminal domain interface [polypeptide binding]; other site 1091494001754 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1091494001755 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1091494001756 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1091494001757 Qi binding site; other site 1091494001758 intrachain domain interface; other site 1091494001759 interchain domain interface [polypeptide binding]; other site 1091494001760 heme bH binding site [chemical binding]; other site 1091494001761 heme bL binding site [chemical binding]; other site 1091494001762 Qo binding site; other site 1091494001763 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1091494001764 interchain domain interface [polypeptide binding]; other site 1091494001765 intrachain domain interface; other site 1091494001766 Qi binding site; other site 1091494001767 Qo binding site; other site 1091494001768 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1091494001769 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1091494001770 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1091494001771 [2Fe-2S] cluster binding site [ion binding]; other site 1091494001772 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 1091494001773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494001774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494001775 homodimer interface [polypeptide binding]; other site 1091494001776 catalytic residue [active] 1091494001777 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1091494001778 histidinol dehydrogenase; Region: hisD; TIGR00069 1091494001779 NAD binding site [chemical binding]; other site 1091494001780 dimerization interface [polypeptide binding]; other site 1091494001781 product binding site; other site 1091494001782 substrate binding site [chemical binding]; other site 1091494001783 zinc binding site [ion binding]; other site 1091494001784 catalytic residues [active] 1091494001785 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1091494001786 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1091494001787 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1091494001788 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1091494001789 hinge; other site 1091494001790 active site 1091494001791 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091494001792 anti sigma factor interaction site; other site 1091494001793 regulatory phosphorylation site [posttranslational modification]; other site 1091494001794 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1091494001795 mce related protein; Region: MCE; pfam02470 1091494001796 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091494001797 Permease; Region: Permease; cl00510 1091494001798 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1091494001799 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1091494001800 Walker A/P-loop; other site 1091494001801 ATP binding site [chemical binding]; other site 1091494001802 Q-loop/lid; other site 1091494001803 ABC transporter signature motif; other site 1091494001804 Walker B; other site 1091494001805 D-loop; other site 1091494001806 H-loop/switch region; other site 1091494001807 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1091494001808 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1091494001809 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1091494001810 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1091494001811 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1091494001812 putative active site [active] 1091494001813 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1091494001814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494001815 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1091494001816 active site 1091494001817 motif I; other site 1091494001818 motif II; other site 1091494001819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1091494001820 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1091494001821 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1091494001822 OstA-like protein; Region: OstA; pfam03968 1091494001823 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1091494001824 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1091494001825 Walker A/P-loop; other site 1091494001826 ATP binding site [chemical binding]; other site 1091494001827 Q-loop/lid; other site 1091494001828 ABC transporter signature motif; other site 1091494001829 Walker B; other site 1091494001830 D-loop; other site 1091494001831 H-loop/switch region; other site 1091494001832 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1091494001833 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1091494001834 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1091494001835 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1091494001836 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1091494001837 30S subunit binding site; other site 1091494001838 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1091494001839 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 1091494001840 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1091494001841 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1091494001842 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1091494001843 Switch I; other site 1091494001844 Switch II; other site 1091494001845 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1091494001846 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1091494001847 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1091494001848 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1091494001849 Phosphate transporter family; Region: PHO4; pfam01384 1091494001850 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1091494001851 ThiC-associated domain; Region: ThiC-associated; pfam13667 1091494001852 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1091494001853 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1091494001854 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1091494001855 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1091494001856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494001857 binding surface 1091494001858 TPR motif; other site 1091494001859 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494001860 metal ion-dependent adhesion site (MIDAS); other site 1091494001861 FliW protein; Region: FliW; cl00740 1091494001862 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1091494001863 tetramerization interface [polypeptide binding]; other site 1091494001864 active site 1091494001865 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1091494001866 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1091494001867 active site 1091494001868 ATP-binding site [chemical binding]; other site 1091494001869 pantoate-binding site; other site 1091494001870 HXXH motif; other site 1091494001871 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1091494001872 oligomerization interface [polypeptide binding]; other site 1091494001873 active site 1091494001874 metal binding site [ion binding]; metal-binding site 1091494001875 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1091494001876 catalytic center binding site [active] 1091494001877 ATP binding site [chemical binding]; other site 1091494001878 poly(A) polymerase; Region: pcnB; TIGR01942 1091494001879 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1091494001880 active site 1091494001881 NTP binding site [chemical binding]; other site 1091494001882 metal binding triad [ion binding]; metal-binding site 1091494001883 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1091494001884 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1091494001885 RDD family; Region: RDD; pfam06271 1091494001886 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1091494001887 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1091494001888 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1091494001889 Predicted permeases [General function prediction only]; Region: COG0795 1091494001890 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1091494001891 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1091494001892 interface (dimer of trimers) [polypeptide binding]; other site 1091494001893 Substrate-binding/catalytic site; other site 1091494001894 Zn-binding sites [ion binding]; other site 1091494001895 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1091494001896 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1091494001897 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1091494001898 HIGH motif; other site 1091494001899 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1091494001900 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1091494001901 active site 1091494001902 KMSKS motif; other site 1091494001903 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1091494001904 tRNA binding surface [nucleotide binding]; other site 1091494001905 anticodon binding site; other site 1091494001906 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1091494001907 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1091494001908 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1091494001909 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1091494001910 Walker A motif; other site 1091494001911 ATP binding site [chemical binding]; other site 1091494001912 Walker B motif; other site 1091494001913 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1091494001914 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494001915 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494001916 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1091494001917 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1091494001918 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1091494001919 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1091494001920 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1091494001921 CoA-binding site [chemical binding]; other site 1091494001922 ATP-binding [chemical binding]; other site 1091494001923 hypothetical protein; Provisional; Region: PRK05287 1091494001924 Domain of unknown function (DUF329); Region: DUF329; cl01144 1091494001925 Daxx Family; Region: Daxx; pfam03344 1091494001926 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1091494001927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091494001928 nucleotide binding site [chemical binding]; other site 1091494001929 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1091494001930 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1091494001931 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494001932 HSP70 interaction site [polypeptide binding]; other site 1091494001933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494001934 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494001935 conjugal transfer protein TraL; Provisional; Region: PRK13886 1091494001936 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091494001937 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1091494001938 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1091494001939 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091494001940 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1091494001941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1091494001942 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1091494001943 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091494001944 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1091494001945 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091494001946 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1091494001947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1091494001948 Plant specific mitochondrial import receptor subunit TOM20; Region: TOM20_plant; pfam06552 1091494001949 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1091494001950 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1091494001951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494001952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091494001953 putative substrate translocation pore; other site 1091494001954 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494001955 Protein kinase domain; Region: Pkinase; pfam00069 1091494001956 active site 1091494001957 ATP binding site [chemical binding]; other site 1091494001958 substrate binding site [chemical binding]; other site 1091494001959 activation loop (A-loop); other site 1091494001960 AAA ATPase domain; Region: AAA_16; pfam13191 1091494001961 Predicted ATPase [General function prediction only]; Region: COG3899 1091494001962 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494001963 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091494001964 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494001965 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494001966 metal binding site [ion binding]; metal-binding site 1091494001967 active site 1091494001968 I-site; other site 1091494001969 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1091494001970 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1091494001971 Glucokinase; Region: Glucokinase; pfam02685 1091494001972 glucokinase, proteobacterial type; Region: glk; TIGR00749 1091494001973 Late competence development protein ComFB; Region: ComFB; pfam10719 1091494001974 Protein of unknown function (DUF721); Region: DUF721; cl02324 1091494001975 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1091494001976 dimer interface [polypeptide binding]; other site 1091494001977 motif 1; other site 1091494001978 active site 1091494001979 motif 2; other site 1091494001980 motif 3; other site 1091494001981 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1091494001982 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1091494001983 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091494001984 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091494001985 putative acyl-acceptor binding pocket; other site 1091494001986 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1091494001987 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1091494001988 putative active site [active] 1091494001989 catalytic triad [active] 1091494001990 putative dimer interface [polypeptide binding]; other site 1091494001991 Transposase; Region: HTH_Tnp_1; cl17663 1091494001992 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494001993 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494001994 Integrase core domain; Region: rve; pfam00665 1091494001995 Integrase core domain; Region: rve_3; pfam13683 1091494001996 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1091494001997 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1091494001998 putative ion selectivity filter; other site 1091494001999 putative pore gating glutamate residue; other site 1091494002000 putative H+/Cl- coupling transport residue; other site 1091494002001 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1091494002002 dimerization interface [polypeptide binding]; other site 1091494002003 active site 1091494002004 RibD C-terminal domain; Region: RibD_C; cl17279 1091494002005 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1091494002006 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1091494002007 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1091494002008 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1091494002009 putative NAD(P) binding site [chemical binding]; other site 1091494002010 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1091494002011 active site 1091494002012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494002013 S-adenosylmethionine binding site [chemical binding]; other site 1091494002014 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494002015 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1091494002016 SWIM zinc finger; Region: SWIM; pfam04434 1091494002017 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1091494002018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494002019 ATP binding site [chemical binding]; other site 1091494002020 putative Mg++ binding site [ion binding]; other site 1091494002021 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1091494002022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494002023 nucleotide binding region [chemical binding]; other site 1091494002024 ATP-binding site [chemical binding]; other site 1091494002025 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494002026 putative active site [active] 1091494002027 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1091494002028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091494002029 Beta-Casp domain; Region: Beta-Casp; smart01027 1091494002030 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1091494002031 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494002032 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1091494002033 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494002034 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1091494002035 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1091494002036 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1091494002037 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1091494002038 NAD(P) binding site [chemical binding]; other site 1091494002039 homodimer interface [polypeptide binding]; other site 1091494002040 substrate binding site [chemical binding]; other site 1091494002041 active site 1091494002042 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091494002043 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091494002044 inhibitor-cofactor binding pocket; inhibition site 1091494002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494002046 catalytic residue [active] 1091494002047 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1091494002048 ligand binding site; other site 1091494002049 tetramer interface; other site 1091494002050 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1091494002051 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091494002052 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1091494002053 active site 1091494002054 nucleotide binding site [chemical binding]; other site 1091494002055 HIGH motif; other site 1091494002056 KMSKS motif; other site 1091494002057 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1091494002058 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1091494002059 active site 1091494002060 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091494002061 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1091494002062 metal-binding site 1091494002063 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091494002064 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091494002065 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091494002066 inhibitor-cofactor binding pocket; inhibition site 1091494002067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494002068 catalytic residue [active] 1091494002069 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1091494002070 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1091494002071 putative trimer interface [polypeptide binding]; other site 1091494002072 putative CoA binding site [chemical binding]; other site 1091494002073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494002074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494002075 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1091494002076 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494002077 LicD family; Region: LicD; pfam04991 1091494002078 pseudaminic acid synthase; Region: PseI; TIGR03586 1091494002079 NeuB family; Region: NeuB; pfam03102 1091494002080 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1091494002081 NeuB binding interface [polypeptide binding]; other site 1091494002082 putative substrate binding site [chemical binding]; other site 1091494002083 flagellin; Provisional; Region: PRK12802 1091494002084 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1091494002085 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1091494002086 FlaG protein; Region: FlaG; pfam03646 1091494002087 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1091494002088 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1091494002089 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1091494002090 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1091494002091 flagellar protein FliS; Validated; Region: fliS; PRK05685 1091494002092 Flagellar protein FliT; Region: FliT; pfam05400 1091494002093 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1091494002094 flagellin; Provisional; Region: PRK12802 1091494002095 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1091494002096 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1091494002097 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1091494002098 signal recognition particle protein; Provisional; Region: PRK10867 1091494002099 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1091494002100 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1091494002101 P loop; other site 1091494002102 GTP binding site [chemical binding]; other site 1091494002103 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1091494002104 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1091494002105 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1091494002106 RimM N-terminal domain; Region: RimM; pfam01782 1091494002107 PRC-barrel domain; Region: PRC; pfam05239 1091494002108 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1091494002109 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1091494002110 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1091494002111 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1091494002112 DNA binding site [nucleotide binding] 1091494002113 active site 1091494002114 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1091494002115 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1091494002116 active site 1091494002117 Int/Topo IB signature motif; other site 1091494002118 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1091494002119 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1091494002120 active site 1091494002121 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1091494002122 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1091494002123 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1091494002124 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1091494002125 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1091494002126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091494002127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494002128 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091494002129 Squalene epoxidase; Region: SE; pfam08491 1091494002130 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 1091494002131 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1091494002132 Active site cavity [active] 1091494002133 catalytic acid [active] 1091494002134 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1091494002135 Cytochrome P450; Region: p450; cl12078 1091494002136 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1091494002137 ornithine cyclodeaminase; Validated; Region: PRK07589 1091494002138 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1091494002139 Ubiquitin-like proteins; Region: UBQ; cl00155 1091494002140 charged pocket; other site 1091494002141 hydrophobic patch; other site 1091494002142 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1091494002143 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1091494002144 NADP binding site [chemical binding]; other site 1091494002145 homodimer interface [polypeptide binding]; other site 1091494002146 active site 1091494002147 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1091494002148 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1091494002149 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1091494002150 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1091494002151 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 1091494002152 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 1091494002153 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1091494002154 ArsC family; Region: ArsC; pfam03960 1091494002155 catalytic residues [active] 1091494002156 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1091494002157 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091494002158 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1091494002159 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1091494002160 putative active site [active] 1091494002161 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 1091494002162 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 1091494002163 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 1091494002164 RmuC family; Region: RmuC; pfam02646 1091494002165 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1091494002166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494002167 ligand binding site [chemical binding]; other site 1091494002168 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1091494002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494002170 ATP binding site [chemical binding]; other site 1091494002171 putative Mg++ binding site [ion binding]; other site 1091494002172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494002173 nucleotide binding region [chemical binding]; other site 1091494002174 ATP-binding site [chemical binding]; other site 1091494002175 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091494002176 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 1091494002177 putative active site [active] 1091494002178 putative metal binding site [ion binding]; other site 1091494002179 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 1091494002180 HipA N-terminal domain; Region: Couple_hipA; cl11853 1091494002181 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1091494002182 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1091494002183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494002184 non-specific DNA binding site [nucleotide binding]; other site 1091494002185 salt bridge; other site 1091494002186 sequence-specific DNA binding site [nucleotide binding]; other site 1091494002187 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1091494002188 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091494002189 active site 1091494002190 acetyl-lysine deacetylase; Validated; Region: PRK00466 1091494002191 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494002192 DNA binding site [nucleotide binding] 1091494002193 active site 1091494002194 Int/Topo IB signature motif; other site 1091494002195 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1091494002196 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1091494002197 putative catalytic cysteine [active] 1091494002198 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091494002199 HDOD domain; Region: HDOD; pfam08668 1091494002200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494002201 Zn2+ binding site [ion binding]; other site 1091494002202 Mg2+ binding site [ion binding]; other site 1091494002203 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494002204 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091494002205 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002207 metal binding site [ion binding]; metal-binding site 1091494002208 active site 1091494002209 I-site; other site 1091494002210 Ceramidase; Region: Ceramidase; pfam05875 1091494002211 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1091494002212 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494002213 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494002214 catalytic residue [active] 1091494002215 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1091494002216 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091494002217 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091494002218 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494002219 catalytic residues [active] 1091494002220 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 1091494002221 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 1091494002222 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1091494002223 ApbE family; Region: ApbE; pfam02424 1091494002224 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1091494002225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494002226 substrate binding pocket [chemical binding]; other site 1091494002227 membrane-bound complex binding site; other site 1091494002228 hinge residues; other site 1091494002229 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494002230 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494002231 catalytic residue [active] 1091494002232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1091494002233 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1091494002234 Family of unknown function (DUF490); Region: DUF490; pfam04357 1091494002235 Family of unknown function (DUF490); Region: DUF490; pfam04357 1091494002236 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1091494002237 Surface antigen; Region: Bac_surface_Ag; pfam01103 1091494002238 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1091494002239 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494002240 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1091494002241 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1091494002242 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1091494002243 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1091494002244 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1091494002245 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1091494002246 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1091494002247 P-loop, Walker A motif; other site 1091494002248 Base recognition motif; other site 1091494002249 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1091494002250 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1091494002251 ZIP Zinc transporter; Region: Zip; pfam02535 1091494002252 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1091494002253 putative active site [active] 1091494002254 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091494002255 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 1091494002256 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091494002257 active site 1091494002258 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1091494002259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091494002260 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1091494002261 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1091494002262 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1091494002263 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1091494002264 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1091494002265 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1091494002266 thioredoxin reductase; Provisional; Region: PRK10262 1091494002267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494002268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494002269 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1091494002270 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1091494002271 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1091494002272 G1 box; other site 1091494002273 putative GEF interaction site [polypeptide binding]; other site 1091494002274 GTP/Mg2+ binding site [chemical binding]; other site 1091494002275 Switch I region; other site 1091494002276 G2 box; other site 1091494002277 G3 box; other site 1091494002278 Switch II region; other site 1091494002279 G4 box; other site 1091494002280 G5 box; other site 1091494002281 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1091494002282 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 1091494002283 DsrE/DsrF-like family; Region: DrsE; cl00672 1091494002284 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1091494002285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494002286 Walker A/P-loop; other site 1091494002287 ATP binding site [chemical binding]; other site 1091494002288 Q-loop/lid; other site 1091494002289 ABC transporter signature motif; other site 1091494002290 Walker B; other site 1091494002291 D-loop; other site 1091494002292 H-loop/switch region; other site 1091494002293 ABC transporter; Region: ABC_tran_2; pfam12848 1091494002294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494002295 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1091494002296 putative hydrophobic ligand binding site [chemical binding]; other site 1091494002297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1091494002298 Histidine kinase; Region: HisKA_3; pfam07730 1091494002299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002300 ATP binding site [chemical binding]; other site 1091494002301 Mg2+ binding site [ion binding]; other site 1091494002302 G-X-G motif; other site 1091494002303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494002304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002305 active site 1091494002306 phosphorylation site [posttranslational modification] 1091494002307 intermolecular recognition site; other site 1091494002308 dimerization interface [polypeptide binding]; other site 1091494002309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494002310 DNA binding residues [nucleotide binding] 1091494002311 dimerization interface [polypeptide binding]; other site 1091494002312 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1091494002313 active site 1091494002314 intersubunit interactions; other site 1091494002315 catalytic residue [active] 1091494002316 Phosphotransferase enzyme family; Region: APH; pfam01636 1091494002317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1091494002318 active site 1091494002319 ATP binding site [chemical binding]; other site 1091494002320 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 1091494002321 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1091494002322 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1091494002323 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1091494002324 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1091494002325 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1091494002326 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1091494002327 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1091494002328 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1091494002329 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 1091494002330 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1091494002331 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1091494002332 glutamine synthetase; Provisional; Region: glnA; PRK09469 1091494002333 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1091494002334 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1091494002335 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1091494002336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002337 putative active site [active] 1091494002338 heme pocket [chemical binding]; other site 1091494002339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494002340 dimer interface [polypeptide binding]; other site 1091494002341 phosphorylation site [posttranslational modification] 1091494002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002343 ATP binding site [chemical binding]; other site 1091494002344 Mg2+ binding site [ion binding]; other site 1091494002345 G-X-G motif; other site 1091494002346 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1091494002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002348 active site 1091494002349 phosphorylation site [posttranslational modification] 1091494002350 intermolecular recognition site; other site 1091494002351 dimerization interface [polypeptide binding]; other site 1091494002352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494002353 Walker A motif; other site 1091494002354 ATP binding site [chemical binding]; other site 1091494002355 Walker B motif; other site 1091494002356 arginine finger; other site 1091494002357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494002358 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1091494002359 TPP-binding site [chemical binding]; other site 1091494002360 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1091494002361 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1091494002362 PYR/PP interface [polypeptide binding]; other site 1091494002363 dimer interface [polypeptide binding]; other site 1091494002364 TPP binding site [chemical binding]; other site 1091494002365 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091494002366 multidrug efflux protein; Reviewed; Region: PRK09579 1091494002367 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494002368 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494002369 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494002370 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494002371 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494002372 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002374 active site 1091494002375 phosphorylation site [posttranslational modification] 1091494002376 intermolecular recognition site; other site 1091494002377 dimerization interface [polypeptide binding]; other site 1091494002378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002379 PAS domain; Region: PAS_9; pfam13426 1091494002380 putative active site [active] 1091494002381 heme pocket [chemical binding]; other site 1091494002382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002384 metal binding site [ion binding]; metal-binding site 1091494002385 active site 1091494002386 I-site; other site 1091494002387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494002388 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002390 active site 1091494002391 phosphorylation site [posttranslational modification] 1091494002392 intermolecular recognition site; other site 1091494002393 dimerization interface [polypeptide binding]; other site 1091494002394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494002395 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002397 putative active site [active] 1091494002398 heme pocket [chemical binding]; other site 1091494002399 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002401 putative active site [active] 1091494002402 heme pocket [chemical binding]; other site 1091494002403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494002404 dimer interface [polypeptide binding]; other site 1091494002405 phosphorylation site [posttranslational modification] 1091494002406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002407 ATP binding site [chemical binding]; other site 1091494002408 Mg2+ binding site [ion binding]; other site 1091494002409 G-X-G motif; other site 1091494002410 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002412 putative active site [active] 1091494002413 heme pocket [chemical binding]; other site 1091494002414 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494002415 GAF domain; Region: GAF; pfam01590 1091494002416 PAS fold; Region: PAS; pfam00989 1091494002417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002418 putative active site [active] 1091494002419 heme pocket [chemical binding]; other site 1091494002420 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494002421 GAF domain; Region: GAF; pfam01590 1091494002422 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1091494002423 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1091494002424 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1091494002425 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494002426 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1091494002427 putative ligand binding site [chemical binding]; other site 1091494002428 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002430 putative active site [active] 1091494002431 heme pocket [chemical binding]; other site 1091494002432 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002433 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002434 metal binding site [ion binding]; metal-binding site 1091494002435 active site 1091494002436 I-site; other site 1091494002437 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494002438 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1091494002439 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1091494002440 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1091494002441 NAD(P) binding site [chemical binding]; other site 1091494002442 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1091494002443 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1091494002444 active site residue [active] 1091494002445 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1091494002446 active site residue [active] 1091494002447 NAD synthetase; Provisional; Region: PRK13981 1091494002448 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1091494002449 multimer interface [polypeptide binding]; other site 1091494002450 active site 1091494002451 catalytic triad [active] 1091494002452 protein interface 1 [polypeptide binding]; other site 1091494002453 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1091494002454 homodimer interface [polypeptide binding]; other site 1091494002455 NAD binding pocket [chemical binding]; other site 1091494002456 ATP binding pocket [chemical binding]; other site 1091494002457 Mg binding site [ion binding]; other site 1091494002458 active-site loop [active] 1091494002459 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1091494002460 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1091494002461 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091494002462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494002463 FeS/SAM binding site; other site 1091494002464 TRAM domain; Region: TRAM; pfam01938 1091494002465 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1091494002466 PhoH-like protein; Region: PhoH; pfam02562 1091494002467 metal-binding heat shock protein; Provisional; Region: PRK00016 1091494002468 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1091494002469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091494002470 Transporter associated domain; Region: CorC_HlyC; smart01091 1091494002471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494002472 binding surface 1091494002473 TPR motif; other site 1091494002474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494002475 TPR motif; other site 1091494002476 binding surface 1091494002477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494002478 TPR motif; other site 1091494002479 binding surface 1091494002480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494002481 binding surface 1091494002482 TPR motif; other site 1091494002483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494002484 binding surface 1091494002485 TPR motif; other site 1091494002486 Nidogen-like; Region: NIDO; cl02648 1091494002487 PEP-CTERM motif; Region: VPEP; pfam07589 1091494002488 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091494002489 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1091494002490 META domain; Region: META; pfam03724 1091494002491 META domain; Region: META; pfam03724 1091494002492 aspartate aminotransferase; Provisional; Region: PRK05764 1091494002493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494002495 homodimer interface [polypeptide binding]; other site 1091494002496 catalytic residue [active] 1091494002497 excinuclease ABC subunit B; Provisional; Region: PRK05298 1091494002498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494002499 ATP binding site [chemical binding]; other site 1091494002500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494002501 nucleotide binding region [chemical binding]; other site 1091494002502 ATP-binding site [chemical binding]; other site 1091494002503 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1091494002504 UvrB/uvrC motif; Region: UVR; pfam02151 1091494002505 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1091494002506 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1091494002507 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494002508 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1091494002509 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494002510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494002511 S-adenosylmethionine binding site [chemical binding]; other site 1091494002512 PAS fold; Region: PAS_4; pfam08448 1091494002513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002514 putative active site [active] 1091494002515 heme pocket [chemical binding]; other site 1091494002516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002517 PAS domain; Region: PAS_9; pfam13426 1091494002518 putative active site [active] 1091494002519 heme pocket [chemical binding]; other site 1091494002520 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002522 metal binding site [ion binding]; metal-binding site 1091494002523 active site 1091494002524 I-site; other site 1091494002525 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494002526 PAS fold; Region: PAS_2; pfam08446 1091494002527 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494002528 GAF domain; Region: GAF; pfam01590 1091494002529 Phytochrome region; Region: PHY; pfam00360 1091494002530 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1091494002531 heme binding pocket [chemical binding]; other site 1091494002532 heme ligand [chemical binding]; other site 1091494002533 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1091494002534 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1091494002535 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1091494002536 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1091494002537 active site 1091494002538 dimer interface [polypeptide binding]; other site 1091494002539 motif 1; other site 1091494002540 motif 2; other site 1091494002541 motif 3; other site 1091494002542 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1091494002543 anticodon binding site; other site 1091494002544 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1091494002545 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1091494002546 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1091494002547 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1091494002548 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1091494002549 23S rRNA binding site [nucleotide binding]; other site 1091494002550 L21 binding site [polypeptide binding]; other site 1091494002551 L13 binding site [polypeptide binding]; other site 1091494002552 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1091494002553 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1091494002554 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1091494002555 dimer interface [polypeptide binding]; other site 1091494002556 motif 1; other site 1091494002557 active site 1091494002558 motif 2; other site 1091494002559 motif 3; other site 1091494002560 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1091494002561 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1091494002562 putative tRNA-binding site [nucleotide binding]; other site 1091494002563 B3/4 domain; Region: B3_4; pfam03483 1091494002564 tRNA synthetase B5 domain; Region: B5; smart00874 1091494002565 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1091494002566 dimer interface [polypeptide binding]; other site 1091494002567 motif 1; other site 1091494002568 motif 3; other site 1091494002569 motif 2; other site 1091494002570 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1091494002571 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1091494002572 IHF dimer interface [polypeptide binding]; other site 1091494002573 IHF - DNA interface [nucleotide binding]; other site 1091494002574 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1091494002575 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091494002576 DNA binding residues [nucleotide binding] 1091494002577 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494002578 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1091494002579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494002580 Walker A motif; other site 1091494002581 ATP binding site [chemical binding]; other site 1091494002582 Walker B motif; other site 1091494002583 arginine finger; other site 1091494002584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494002585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1091494002586 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1091494002587 putative active site [active] 1091494002588 heme pocket [chemical binding]; other site 1091494002589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494002590 dimer interface [polypeptide binding]; other site 1091494002591 phosphorylation site [posttranslational modification] 1091494002592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002593 ATP binding site [chemical binding]; other site 1091494002594 Mg2+ binding site [ion binding]; other site 1091494002595 G-X-G motif; other site 1091494002596 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002598 active site 1091494002599 phosphorylation site [posttranslational modification] 1091494002600 intermolecular recognition site; other site 1091494002601 dimerization interface [polypeptide binding]; other site 1091494002602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494002603 Walker A motif; other site 1091494002604 ATP binding site [chemical binding]; other site 1091494002605 Walker B motif; other site 1091494002606 arginine finger; other site 1091494002607 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494002608 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1091494002609 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1091494002610 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1091494002611 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1091494002612 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1091494002613 MgtE intracellular N domain; Region: MgtE_N; smart00924 1091494002614 FliG C-terminal domain; Region: FliG_C; pfam01706 1091494002615 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1091494002616 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1091494002617 Flagellar assembly protein FliH; Region: FliH; pfam02108 1091494002618 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1091494002619 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1091494002620 Walker A motif/ATP binding site; other site 1091494002621 Walker B motif; other site 1091494002622 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1091494002623 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1091494002624 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1091494002625 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1091494002626 ABC1 family; Region: ABC1; pfam03109 1091494002627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1091494002628 active site 1091494002629 ATP binding site [chemical binding]; other site 1091494002630 Cupin domain; Region: Cupin_2; cl17218 1091494002631 Predicted membrane protein [Function unknown]; Region: COG2259 1091494002632 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1091494002633 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1091494002634 Moco binding site; other site 1091494002635 metal coordination site [ion binding]; other site 1091494002636 Hemerythrin; Region: Hemerythrin; cd12107 1091494002637 Fe binding site [ion binding]; other site 1091494002638 PAS fold; Region: PAS; pfam00989 1091494002639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002640 putative active site [active] 1091494002641 heme pocket [chemical binding]; other site 1091494002642 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1091494002643 dimer interface [polypeptide binding]; other site 1091494002644 phosphorylation site [posttranslational modification] 1091494002645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002646 ATP binding site [chemical binding]; other site 1091494002647 Mg2+ binding site [ion binding]; other site 1091494002648 G-X-G motif; other site 1091494002649 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1091494002650 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091494002651 G1 box; other site 1091494002652 GTP/Mg2+ binding site [chemical binding]; other site 1091494002653 G2 box; other site 1091494002654 Switch I region; other site 1091494002655 G3 box; other site 1091494002656 Switch II region; other site 1091494002657 G4 box; other site 1091494002658 G5 box; other site 1091494002659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494002660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1091494002661 dimer interface [polypeptide binding]; other site 1091494002662 phosphorylation site [posttranslational modification] 1091494002663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002664 ATP binding site [chemical binding]; other site 1091494002665 Mg2+ binding site [ion binding]; other site 1091494002666 G-X-G motif; other site 1091494002667 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002669 active site 1091494002670 phosphorylation site [posttranslational modification] 1091494002671 intermolecular recognition site; other site 1091494002672 dimerization interface [polypeptide binding]; other site 1091494002673 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1091494002674 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1091494002675 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1091494002676 Walker A motif; other site 1091494002677 ATP binding site [chemical binding]; other site 1091494002678 Walker B motif; other site 1091494002679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1091494002680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494002681 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1091494002682 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002684 active site 1091494002685 phosphorylation site [posttranslational modification] 1091494002686 intermolecular recognition site; other site 1091494002687 dimerization interface [polypeptide binding]; other site 1091494002688 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494002689 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091494002690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002691 PAS fold; Region: PAS_3; pfam08447 1091494002692 putative active site [active] 1091494002693 heme pocket [chemical binding]; other site 1091494002694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494002695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494002696 dimer interface [polypeptide binding]; other site 1091494002697 phosphorylation site [posttranslational modification] 1091494002698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002699 ATP binding site [chemical binding]; other site 1091494002700 Mg2+ binding site [ion binding]; other site 1091494002701 G-X-G motif; other site 1091494002702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002704 metal binding site [ion binding]; metal-binding site 1091494002705 active site 1091494002706 I-site; other site 1091494002707 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1091494002708 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1091494002709 active site 1091494002710 (T/H)XGH motif; other site 1091494002711 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1091494002712 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1091494002713 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1091494002714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494002715 FeS/SAM binding site; other site 1091494002716 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1091494002717 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1091494002718 hypothetical protein; Provisional; Region: PRK14641 1091494002719 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1091494002720 putative oligomer interface [polypeptide binding]; other site 1091494002721 putative RNA binding site [nucleotide binding]; other site 1091494002722 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1091494002723 NusA N-terminal domain; Region: NusA_N; pfam08529 1091494002724 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1091494002725 RNA binding site [nucleotide binding]; other site 1091494002726 homodimer interface [polypeptide binding]; other site 1091494002727 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1091494002728 G-X-X-G motif; other site 1091494002729 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1091494002730 G-X-X-G motif; other site 1091494002731 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1091494002732 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1091494002733 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1091494002734 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1091494002735 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1091494002736 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1091494002737 G1 box; other site 1091494002738 putative GEF interaction site [polypeptide binding]; other site 1091494002739 GTP/Mg2+ binding site [chemical binding]; other site 1091494002740 Switch I region; other site 1091494002741 G2 box; other site 1091494002742 G3 box; other site 1091494002743 Switch II region; other site 1091494002744 G4 box; other site 1091494002745 G5 box; other site 1091494002746 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1091494002747 Translation-initiation factor 2; Region: IF-2; pfam11987 1091494002748 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1091494002749 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1091494002750 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1091494002751 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1091494002752 RNA binding site [nucleotide binding]; other site 1091494002753 active site 1091494002754 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1091494002755 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1091494002756 16S/18S rRNA binding site [nucleotide binding]; other site 1091494002757 S13e-L30e interaction site [polypeptide binding]; other site 1091494002758 25S rRNA binding site [nucleotide binding]; other site 1091494002759 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1091494002760 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1091494002761 RNase E interface [polypeptide binding]; other site 1091494002762 trimer interface [polypeptide binding]; other site 1091494002763 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1091494002764 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1091494002765 RNase E interface [polypeptide binding]; other site 1091494002766 trimer interface [polypeptide binding]; other site 1091494002767 active site 1091494002768 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1091494002769 putative nucleic acid binding region [nucleotide binding]; other site 1091494002770 G-X-X-G motif; other site 1091494002771 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1091494002772 RNA binding site [nucleotide binding]; other site 1091494002773 domain interface; other site 1091494002774 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1091494002775 Cytochrome c; Region: Cytochrom_C; cl11414 1091494002776 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1091494002777 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1091494002778 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494002779 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 1091494002780 putative active site [active] 1091494002781 Zn binding site [ion binding]; other site 1091494002782 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1091494002783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091494002784 Coenzyme A binding pocket [chemical binding]; other site 1091494002785 Peptidase_C39 like family; Region: DUF3335; pfam11814 1091494002786 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 1091494002787 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1091494002788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494002789 N-terminal plug; other site 1091494002790 ligand-binding site [chemical binding]; other site 1091494002791 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1091494002792 homotrimer interface [polypeptide binding]; other site 1091494002793 Walker A motif; other site 1091494002794 GTP binding site [chemical binding]; other site 1091494002795 Walker B motif; other site 1091494002796 cobyric acid synthase; Provisional; Region: PRK00784 1091494002797 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1091494002798 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1091494002799 catalytic triad [active] 1091494002800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091494002801 catalytic core [active] 1091494002802 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1091494002803 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1091494002804 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091494002805 catalytic triad [active] 1091494002806 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1091494002807 Domain of unknown function DUF29; Region: DUF29; pfam01724 1091494002808 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1091494002809 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1091494002810 putative dimer interface [polypeptide binding]; other site 1091494002811 active site pocket [active] 1091494002812 putative cataytic base [active] 1091494002813 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1091494002814 FMN binding site [chemical binding]; other site 1091494002815 dimer interface [polypeptide binding]; other site 1091494002816 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1091494002817 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1091494002818 putative active site [active] 1091494002819 putative substrate binding site [chemical binding]; other site 1091494002820 ATP binding site [chemical binding]; other site 1091494002821 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1091494002822 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1091494002823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494002825 homodimer interface [polypeptide binding]; other site 1091494002826 catalytic residue [active] 1091494002827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494002828 active site residue [active] 1091494002829 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1091494002830 trehalose synthase; Region: treS_nterm; TIGR02456 1091494002831 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1091494002832 active site 1091494002833 catalytic site [active] 1091494002834 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1091494002835 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1091494002836 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 1091494002837 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091494002838 FAD binding domain; Region: FAD_binding_4; pfam01565 1091494002839 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091494002840 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1091494002841 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1091494002842 Cysteine-rich domain; Region: CCG; pfam02754 1091494002843 Cysteine-rich domain; Region: CCG; pfam02754 1091494002844 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 1091494002845 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582 1091494002846 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1091494002847 active site 1091494002848 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1091494002849 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494002850 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1091494002851 Walker A/P-loop; other site 1091494002852 ATP binding site [chemical binding]; other site 1091494002853 Q-loop/lid; other site 1091494002854 ABC transporter signature motif; other site 1091494002855 Walker B; other site 1091494002856 D-loop; other site 1091494002857 H-loop/switch region; other site 1091494002858 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1091494002859 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494002860 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494002861 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1091494002862 SapC; Region: SapC; pfam07277 1091494002863 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1091494002864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1091494002865 DNA binding residues [nucleotide binding] 1091494002866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091494002867 Integrase core domain; Region: rve; pfam00665 1091494002868 transposase; Provisional; Region: PRK06526 1091494002869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494002870 Walker A motif; other site 1091494002871 ATP binding site [chemical binding]; other site 1091494002872 Walker B motif; other site 1091494002873 rod shape-determining protein MreC; Provisional; Region: PRK13922 1091494002874 Integrase core domain; Region: rve; pfam00665 1091494002875 Integrase core domain; Region: rve_3; pfam13683 1091494002876 phosphodiesterase; Provisional; Region: PRK12704 1091494002877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494002878 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494002879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1091494002880 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1091494002881 FlgN protein; Region: FlgN; pfam05130 1091494002882 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1091494002883 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1091494002884 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1091494002885 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1091494002886 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494002887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002888 active site 1091494002889 phosphorylation site [posttranslational modification] 1091494002890 intermolecular recognition site; other site 1091494002891 dimerization interface [polypeptide binding]; other site 1091494002892 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494002893 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1091494002894 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494002895 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1091494002896 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1091494002897 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 1091494002898 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1091494002899 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1091494002900 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 1091494002901 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1091494002902 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1091494002903 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1091494002904 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1091494002905 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1091494002906 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1091494002907 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1091494002908 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1091494002909 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1091494002910 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1091494002911 Flagellar L-ring protein; Region: FlgH; pfam02107 1091494002912 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1091494002913 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1091494002914 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1091494002915 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1091494002916 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1091494002917 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1091494002918 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1091494002919 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1091494002920 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 1091494002921 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1091494002922 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1091494002923 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1091494002924 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1091494002925 MEKHLA domain; Region: MEKHLA; pfam08670 1091494002926 Acylphosphatase; Region: Acylphosphatase; pfam00708 1091494002927 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1091494002928 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1091494002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494002930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494002931 S-adenosylmethionine binding site [chemical binding]; other site 1091494002932 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494002933 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1091494002934 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1091494002935 catalytic site [active] 1091494002936 putative active site [active] 1091494002937 putative substrate binding site [chemical binding]; other site 1091494002938 HRDC domain; Region: HRDC; pfam00570 1091494002939 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494002940 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 1091494002941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494002942 dimerization interface [polypeptide binding]; other site 1091494002943 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002945 putative active site [active] 1091494002946 heme pocket [chemical binding]; other site 1091494002947 PAS domain S-box; Region: sensory_box; TIGR00229 1091494002948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002949 putative active site [active] 1091494002950 heme pocket [chemical binding]; other site 1091494002951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494002953 putative active site [active] 1091494002954 heme pocket [chemical binding]; other site 1091494002955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494002956 dimer interface [polypeptide binding]; other site 1091494002957 phosphorylation site [posttranslational modification] 1091494002958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494002959 ATP binding site [chemical binding]; other site 1091494002960 Mg2+ binding site [ion binding]; other site 1091494002961 G-X-G motif; other site 1091494002962 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002964 active site 1091494002965 phosphorylation site [posttranslational modification] 1091494002966 intermolecular recognition site; other site 1091494002967 dimerization interface [polypeptide binding]; other site 1091494002968 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494002969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002970 active site 1091494002971 phosphorylation site [posttranslational modification] 1091494002972 intermolecular recognition site; other site 1091494002973 dimerization interface [polypeptide binding]; other site 1091494002974 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1091494002975 putative binding surface; other site 1091494002976 active site 1091494002977 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494002978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494002979 active site 1091494002980 phosphorylation site [posttranslational modification] 1091494002981 intermolecular recognition site; other site 1091494002982 dimerization interface [polypeptide binding]; other site 1091494002983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494002984 PAS domain; Region: PAS_9; pfam13426 1091494002985 putative active site [active] 1091494002986 heme pocket [chemical binding]; other site 1091494002987 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494002988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494002989 metal binding site [ion binding]; metal-binding site 1091494002990 active site 1091494002991 I-site; other site 1091494002992 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494002993 glycine dehydrogenase; Provisional; Region: PRK05367 1091494002994 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091494002995 tetramer interface [polypeptide binding]; other site 1091494002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494002997 catalytic residue [active] 1091494002998 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1091494002999 tetramer interface [polypeptide binding]; other site 1091494003000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494003001 catalytic residue [active] 1091494003002 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1091494003003 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1091494003004 HDOD domain; Region: HDOD; pfam08668 1091494003005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494003006 Zn2+ binding site [ion binding]; other site 1091494003007 Mg2+ binding site [ion binding]; other site 1091494003008 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494003009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494003010 active site 1091494003011 phosphorylation site [posttranslational modification] 1091494003012 intermolecular recognition site; other site 1091494003013 dimerization interface [polypeptide binding]; other site 1091494003014 PAS domain S-box; Region: sensory_box; TIGR00229 1091494003015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494003016 putative active site [active] 1091494003017 heme pocket [chemical binding]; other site 1091494003018 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003020 metal binding site [ion binding]; metal-binding site 1091494003021 active site 1091494003022 I-site; other site 1091494003023 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494003024 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494003025 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494003026 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494003027 Protein of unknown function (DUF502); Region: DUF502; cl01107 1091494003028 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1091494003029 GTPase RsgA; Reviewed; Region: PRK00098 1091494003030 RNA binding site [nucleotide binding]; other site 1091494003031 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1091494003032 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1091494003033 GTP/Mg2+ binding site [chemical binding]; other site 1091494003034 G4 box; other site 1091494003035 G5 box; other site 1091494003036 G1 box; other site 1091494003037 Switch I region; other site 1091494003038 G2 box; other site 1091494003039 G3 box; other site 1091494003040 Switch II region; other site 1091494003041 Peptidase family M48; Region: Peptidase_M48; cl12018 1091494003042 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1091494003043 catalytic site [active] 1091494003044 putative active site [active] 1091494003045 putative substrate binding site [chemical binding]; other site 1091494003046 dimer interface [polypeptide binding]; other site 1091494003047 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1091494003048 CrcB-like protein; Region: CRCB; cl09114 1091494003049 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1091494003050 seryl-tRNA synthetase; Provisional; Region: PRK05431 1091494003051 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1091494003052 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1091494003053 dimer interface [polypeptide binding]; other site 1091494003054 active site 1091494003055 motif 1; other site 1091494003056 motif 2; other site 1091494003057 motif 3; other site 1091494003058 PBP superfamily domain; Region: PBP_like_2; pfam12849 1091494003059 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091494003060 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494003061 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494003062 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1091494003063 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494003064 PAS domain; Region: PAS_10; pfam13596 1091494003065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494003066 PAS domain; Region: PAS_9; pfam13426 1091494003067 putative active site [active] 1091494003068 heme pocket [chemical binding]; other site 1091494003069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003071 metal binding site [ion binding]; metal-binding site 1091494003072 active site 1091494003073 I-site; other site 1091494003074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494003075 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1091494003076 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1091494003077 thiamine phosphate binding site [chemical binding]; other site 1091494003078 active site 1091494003079 pyrophosphate binding site [ion binding]; other site 1091494003080 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1091494003081 dimer interface [polypeptide binding]; other site 1091494003082 substrate binding site [chemical binding]; other site 1091494003083 ATP binding site [chemical binding]; other site 1091494003084 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1091494003085 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091494003086 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494003087 catalytic residues [active] 1091494003088 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1091494003089 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1091494003090 ligand binding site [chemical binding]; other site 1091494003091 NAD binding site [chemical binding]; other site 1091494003092 dimerization interface [polypeptide binding]; other site 1091494003093 catalytic site [active] 1091494003094 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1091494003095 putative L-serine binding site [chemical binding]; other site 1091494003096 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1091494003097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494003098 motif II; other site 1091494003099 hypothetical protein; Validated; Region: PRK00110 1091494003100 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1091494003101 active site 1091494003102 putative DNA-binding cleft [nucleotide binding]; other site 1091494003103 dimer interface [polypeptide binding]; other site 1091494003104 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1091494003105 RuvA N terminal domain; Region: RuvA_N; pfam01330 1091494003106 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1091494003107 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1091494003108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494003109 Walker A motif; other site 1091494003110 ATP binding site [chemical binding]; other site 1091494003111 Walker B motif; other site 1091494003112 arginine finger; other site 1091494003113 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1091494003114 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091494003115 active site 1091494003116 TolQ protein; Region: tolQ; TIGR02796 1091494003117 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494003118 TolR protein; Region: tolR; TIGR02801 1091494003119 TolA protein; Region: tolA_full; TIGR02794 1091494003120 TonB C terminal; Region: TonB_2; pfam13103 1091494003121 translocation protein TolB; Provisional; Region: tolB; PRK04922 1091494003122 TolB amino-terminal domain; Region: TolB_N; pfam04052 1091494003123 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091494003124 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091494003125 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091494003126 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494003127 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494003128 ligand binding site [chemical binding]; other site 1091494003129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494003130 binding surface 1091494003131 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494003132 TPR motif; other site 1091494003133 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1091494003134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494003135 FeS/SAM binding site; other site 1091494003136 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1091494003137 Ligand Binding Site [chemical binding]; other site 1091494003138 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494003139 active site 1091494003140 DNA binding site [nucleotide binding] 1091494003141 Int/Topo IB signature motif; other site 1091494003142 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1091494003143 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1091494003144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494003145 FeS/SAM binding site; other site 1091494003146 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1091494003147 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1091494003148 catalytic motif [active] 1091494003149 Catalytic residue [active] 1091494003150 Type II transport protein GspH; Region: GspH; pfam12019 1091494003151 hypothetical protein; Provisional; Region: PRK10557 1091494003152 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 1091494003153 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 1091494003154 AAA ATPase domain; Region: AAA_16; pfam13191 1091494003155 AAA domain; Region: AAA_22; pfam13401 1091494003156 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091494003157 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1091494003158 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1091494003159 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1091494003160 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1091494003161 active site 1091494003162 DNA binding site [nucleotide binding] 1091494003163 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1091494003164 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1091494003165 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091494003166 Catalytic site [active] 1091494003167 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1091494003168 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1091494003169 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091494003170 Catalytic site [active] 1091494003171 LexA repressor; Validated; Region: PRK00215 1091494003172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494003173 putative DNA binding site [nucleotide binding]; other site 1091494003174 putative Zn2+ binding site [ion binding]; other site 1091494003175 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091494003176 Catalytic site [active] 1091494003177 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1091494003178 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1091494003179 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1091494003180 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1091494003181 DNA-binding interface [nucleotide binding]; DNA binding site 1091494003182 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1091494003183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494003184 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494003185 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 1091494003186 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 1091494003187 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 1091494003188 dimer interface [polypeptide binding]; other site 1091494003189 substrate binding site [chemical binding]; other site 1091494003190 metal binding sites [ion binding]; metal-binding site 1091494003191 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091494003192 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1091494003193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091494003194 Divalent cation transporter; Region: MgtE; pfam01769 1091494003195 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1091494003196 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1091494003197 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1091494003198 NADPH bind site [chemical binding]; other site 1091494003199 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1091494003200 putative FMN binding site [chemical binding]; other site 1091494003201 NADPH bind site [chemical binding]; other site 1091494003202 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091494003203 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091494003204 HDOD domain; Region: HDOD; pfam08668 1091494003205 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1091494003206 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091494003207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091494003208 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091494003209 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1091494003210 CoA binding domain; Region: CoA_binding_2; pfam13380 1091494003211 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1091494003212 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1091494003213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1091494003214 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091494003215 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1091494003216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1091494003217 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1091494003218 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1091494003219 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091494003220 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003221 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003222 metal binding site [ion binding]; metal-binding site 1091494003223 active site 1091494003224 I-site; other site 1091494003225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494003226 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1091494003227 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 1091494003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494003229 active site 1091494003230 motif I; other site 1091494003231 motif II; other site 1091494003232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494003233 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1091494003234 Predicted membrane protein [Function unknown]; Region: COG2119 1091494003235 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1091494003236 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1091494003237 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1091494003238 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091494003239 G1 box; other site 1091494003240 GTP/Mg2+ binding site [chemical binding]; other site 1091494003241 G2 box; other site 1091494003242 Switch I region; other site 1091494003243 G3 box; other site 1091494003244 Switch II region; other site 1091494003245 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1091494003246 GTP/Mg2+ binding site [chemical binding]; other site 1091494003247 G4 box; other site 1091494003248 G5 box; other site 1091494003249 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091494003250 G1 box; other site 1091494003251 G1 box; other site 1091494003252 GTP/Mg2+ binding site [chemical binding]; other site 1091494003253 Switch I region; other site 1091494003254 G2 box; other site 1091494003255 G2 box; other site 1091494003256 Switch I region; other site 1091494003257 G3 box; other site 1091494003258 G3 box; other site 1091494003259 Switch II region; other site 1091494003260 Switch II region; other site 1091494003261 G4 box; other site 1091494003262 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1091494003263 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1091494003264 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494003265 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494003266 ligand binding site [chemical binding]; other site 1091494003267 flexible hinge region; other site 1091494003268 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091494003269 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494003270 phosphopeptide binding site; other site 1091494003271 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003273 metal binding site [ion binding]; metal-binding site 1091494003274 active site 1091494003275 I-site; other site 1091494003276 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1091494003277 nudix motif; other site 1091494003278 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1091494003279 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1091494003280 malate dehydrogenase; Provisional; Region: PRK13529 1091494003281 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1091494003282 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1091494003283 NAD(P) binding site [chemical binding]; other site 1091494003284 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1091494003285 homodimer interface [polypeptide binding]; other site 1091494003286 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1091494003287 active site pocket [active] 1091494003288 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1091494003289 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1091494003290 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1091494003291 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1091494003292 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 1091494003293 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1091494003294 nucleotide binding site [chemical binding]; other site 1091494003295 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1091494003296 SBD interface [polypeptide binding]; other site 1091494003297 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1091494003298 nucleotide binding site [chemical binding]; other site 1091494003299 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1091494003300 SBD interface [polypeptide binding]; other site 1091494003301 DNA-K related protein; Region: DUF3731; pfam12531 1091494003302 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1091494003303 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1091494003304 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1091494003305 MutS domain I; Region: MutS_I; pfam01624 1091494003306 MutS domain II; Region: MutS_II; pfam05188 1091494003307 MutS domain III; Region: MutS_III; pfam05192 1091494003308 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1091494003309 Walker A/P-loop; other site 1091494003310 ATP binding site [chemical binding]; other site 1091494003311 Q-loop/lid; other site 1091494003312 ABC transporter signature motif; other site 1091494003313 Walker B; other site 1091494003314 D-loop; other site 1091494003315 H-loop/switch region; other site 1091494003316 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1091494003317 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091494003318 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091494003319 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1091494003320 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1091494003321 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1091494003322 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494003323 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494003324 Integrase core domain; Region: rve; pfam00665 1091494003325 Integrase core domain; Region: rve_3; pfam13683 1091494003326 Transposase; Region: HTH_Tnp_1; cl17663 1091494003327 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1091494003328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494003329 Walker A/P-loop; other site 1091494003330 ATP binding site [chemical binding]; other site 1091494003331 Q-loop/lid; other site 1091494003332 ABC transporter signature motif; other site 1091494003333 Walker B; other site 1091494003334 D-loop; other site 1091494003335 H-loop/switch region; other site 1091494003336 TOBE domain; Region: TOBE; pfam03459 1091494003337 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494003338 Sel1-like repeats; Region: SEL1; smart00671 1091494003339 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1091494003340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1091494003341 active site 1091494003342 HIGH motif; other site 1091494003343 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1091494003344 active site 1091494003345 KMSKS motif; other site 1091494003346 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1091494003347 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1091494003348 heme binding site [chemical binding]; other site 1091494003349 ferroxidase pore; other site 1091494003350 ferroxidase diiron center [ion binding]; other site 1091494003351 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1091494003352 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1091494003353 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1091494003354 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1091494003355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494003356 glutathione reductase; Validated; Region: PRK06116 1091494003357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494003358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494003359 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494003360 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1091494003361 catalytic triad [active] 1091494003362 dimer interface [polypeptide binding]; other site 1091494003363 Uncharacterized conserved protein [Function unknown]; Region: COG3461 1091494003364 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1091494003365 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1091494003366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1091494003367 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1091494003368 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1091494003369 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1091494003370 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1091494003371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1091494003372 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1091494003373 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494003374 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494003375 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091494003376 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1091494003377 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1091494003378 V4R domain; Region: V4R; cl15268 1091494003379 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1091494003380 apolar tunnel; other site 1091494003381 heme binding site [chemical binding]; other site 1091494003382 dimerization interface [polypeptide binding]; other site 1091494003383 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091494003384 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1091494003385 catalytic loop [active] 1091494003386 iron binding site [ion binding]; other site 1091494003387 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1091494003388 FAD binding pocket [chemical binding]; other site 1091494003389 FAD binding motif [chemical binding]; other site 1091494003390 phosphate binding motif [ion binding]; other site 1091494003391 beta-alpha-beta structure motif; other site 1091494003392 NAD binding pocket [chemical binding]; other site 1091494003393 Cytochrome c; Region: Cytochrom_C; pfam00034 1091494003394 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1091494003395 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1091494003396 Low-spin heme binding site [chemical binding]; other site 1091494003397 D-pathway; other site 1091494003398 Putative water exit pathway; other site 1091494003399 Binuclear center (active site) [active] 1091494003400 K-pathway; other site 1091494003401 Putative proton exit pathway; other site 1091494003402 Protein of unknown function DUF45; Region: DUF45; pfam01863 1091494003403 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1091494003404 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494003405 catalytic residues [active] 1091494003406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494003407 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1091494003408 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1091494003409 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1091494003410 putative active site [active] 1091494003411 metal binding site [ion binding]; metal-binding site 1091494003412 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1091494003413 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494003414 acyl-activating enzyme (AAE) consensus motif; other site 1091494003415 active site 1091494003416 AMP binding site [chemical binding]; other site 1091494003417 CoA binding site [chemical binding]; other site 1091494003418 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1091494003419 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1091494003420 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1091494003421 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1091494003422 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1091494003423 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1091494003424 D-pathway; other site 1091494003425 Putative ubiquinol binding site [chemical binding]; other site 1091494003426 Low-spin heme (heme b) binding site [chemical binding]; other site 1091494003427 Putative water exit pathway; other site 1091494003428 Binuclear center (heme o3/CuB) [ion binding]; other site 1091494003429 K-pathway; other site 1091494003430 Putative proton exit pathway; other site 1091494003431 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1091494003432 Subunit I/III interface [polypeptide binding]; other site 1091494003433 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1091494003434 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1091494003435 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1091494003436 active site 1091494003437 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1091494003438 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1091494003439 active site 1091494003440 NTP binding site [chemical binding]; other site 1091494003441 metal binding triad [ion binding]; metal-binding site 1091494003442 antibiotic binding site [chemical binding]; other site 1091494003443 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494003444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494003445 S-adenosylmethionine binding site [chemical binding]; other site 1091494003446 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1091494003447 PLD-like domain; Region: PLDc_2; pfam13091 1091494003448 putative active site [active] 1091494003449 catalytic site [active] 1091494003450 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1091494003451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494003452 ATP binding site [chemical binding]; other site 1091494003453 putative Mg++ binding site [ion binding]; other site 1091494003454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494003455 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1091494003456 nucleotide binding region [chemical binding]; other site 1091494003457 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091494003458 Catalytic site [active] 1091494003459 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494003460 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1091494003461 Restriction endonuclease; Region: Mrr_cat; pfam04471 1091494003462 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1091494003463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494003464 ATP binding site [chemical binding]; other site 1091494003465 putative Mg++ binding site [ion binding]; other site 1091494003466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494003467 nucleotide binding region [chemical binding]; other site 1091494003468 ATP-binding site [chemical binding]; other site 1091494003469 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1091494003470 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1091494003471 active site 1091494003472 NTP binding site [chemical binding]; other site 1091494003473 metal binding triad [ion binding]; metal-binding site 1091494003474 antibiotic binding site [chemical binding]; other site 1091494003475 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1091494003476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1091494003477 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494003478 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1091494003479 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494003480 putative active site [active] 1091494003481 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494003482 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1091494003483 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1091494003484 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494003485 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1091494003486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 1091494003487 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 1091494003488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1091494003489 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 1091494003490 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091494003491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1091494003492 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1091494003493 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091494003494 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1091494003495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494003496 catalytic residue [active] 1091494003497 Short C-terminal domain; Region: SHOCT; pfam09851 1091494003498 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1091494003499 SWIM zinc finger; Region: SWIM; pfam04434 1091494003500 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494003501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494003502 S-adenosylmethionine binding site [chemical binding]; other site 1091494003503 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1091494003504 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1091494003505 catalytic residues [active] 1091494003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1091494003507 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1091494003508 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1091494003509 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1091494003510 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1091494003511 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1091494003512 Outer membrane lipoprotein; Region: YfiO; pfam13525 1091494003513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494003514 TPR motif; other site 1091494003515 binding surface 1091494003516 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1091494003517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091494003518 RNA binding surface [nucleotide binding]; other site 1091494003519 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1091494003520 active site 1091494003521 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1091494003522 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1091494003523 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1091494003524 ZIP Zinc transporter; Region: Zip; pfam02535 1091494003525 phosphoglucomutase; Region: PLN02307 1091494003526 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1091494003527 active site 1091494003528 substrate binding site [chemical binding]; other site 1091494003529 metal binding site [ion binding]; metal-binding site 1091494003530 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494003531 VacJ like lipoprotein; Region: VacJ; cl01073 1091494003532 L,D-transpeptidase; Provisional; Region: PRK10260 1091494003533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494003534 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494003535 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1091494003536 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1091494003537 putative active site [active] 1091494003538 hypothetical protein; Provisional; Region: PRK05255 1091494003539 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1091494003540 active site 1091494003541 DNA polymerase IV; Validated; Region: PRK02406 1091494003542 DNA binding site [nucleotide binding] 1091494003543 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1091494003544 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 1091494003545 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1091494003546 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1091494003547 active site 1091494003548 Int/Topo IB signature motif; other site 1091494003549 Protein of unknown function, DUF484; Region: DUF484; cl17449 1091494003550 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1091494003551 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091494003552 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1091494003553 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1091494003554 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1091494003555 active site 1091494003556 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494003557 substrate binding site [chemical binding]; other site 1091494003558 catalytic residues [active] 1091494003559 dimer interface [polypeptide binding]; other site 1091494003560 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1091494003561 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1091494003562 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1091494003563 DctM-like transporters; Region: DctM; pfam06808 1091494003564 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1091494003565 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494003566 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494003567 catalytic residue [active] 1091494003568 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1091494003569 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1091494003570 active site 1091494003571 NTP binding site [chemical binding]; other site 1091494003572 metal binding triad [ion binding]; metal-binding site 1091494003573 antibiotic binding site [chemical binding]; other site 1091494003574 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1091494003575 Peptidase family M23; Region: Peptidase_M23; pfam01551 1091494003576 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 1091494003577 hypothetical protein; Provisional; Region: PRK10557 1091494003578 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1091494003579 Type II transport protein GspH; Region: GspH; pfam12019 1091494003580 Type II transport protein GspH; Region: GspH; pfam12019 1091494003581 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1091494003582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1091494003583 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494003584 putative active site [active] 1091494003585 Haemagglutinin; Region: Hemagglutinin; pfam00509 1091494003586 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1091494003587 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1091494003588 metal binding site [ion binding]; metal-binding site 1091494003589 dimer interface [polypeptide binding]; other site 1091494003590 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1091494003591 ArsC family; Region: ArsC; pfam03960 1091494003592 putative catalytic residues [active] 1091494003593 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494003594 putative active site [active] 1091494003595 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1091494003596 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1091494003597 trimer interface [polypeptide binding]; other site 1091494003598 active site 1091494003599 substrate binding site [chemical binding]; other site 1091494003600 CoA binding site [chemical binding]; other site 1091494003601 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1091494003602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494003603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494003604 homodimer interface [polypeptide binding]; other site 1091494003605 catalytic residue [active] 1091494003606 Peptidase family M48; Region: Peptidase_M48; pfam01435 1091494003607 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 1091494003608 The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761 1091494003609 putative [4Fe-4S] binding site [ion binding]; other site 1091494003610 putative molybdopterin cofactor binding site [chemical binding]; other site 1091494003611 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 1091494003612 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 1091494003613 active site 1091494003614 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1091494003615 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1091494003616 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1091494003617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1091494003618 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 1091494003619 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 1091494003620 FTR, proximal lobe; Region: FTR_C; pfam02741 1091494003621 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 1091494003622 putative subunit interface; other site 1091494003623 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1091494003624 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1091494003625 ANTAR domain; Region: ANTAR; pfam03861 1091494003626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494003627 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1091494003628 putative substrate translocation pore; other site 1091494003629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494003630 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1091494003631 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494003632 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1091494003633 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1091494003634 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091494003635 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1091494003636 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1091494003637 cyanate hydratase; Validated; Region: PRK02866 1091494003638 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1091494003639 oligomer interface [polypeptide binding]; other site 1091494003640 active site 1091494003641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091494003642 active site 1091494003643 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494003644 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494003645 active site 1091494003646 ATP binding site [chemical binding]; other site 1091494003647 substrate binding site [chemical binding]; other site 1091494003648 activation loop (A-loop); other site 1091494003649 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1091494003650 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1091494003651 TM2 domain; Region: TM2; cl00984 1091494003652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091494003653 Ligand Binding Site [chemical binding]; other site 1091494003654 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1091494003655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494003656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494003657 ABC transporter; Region: ABC_tran_2; pfam12848 1091494003658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1091494003659 YcxB-like protein; Region: YcxB; pfam14317 1091494003660 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1091494003661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494003662 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091494003663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091494003664 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091494003665 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494003666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494003667 active site 1091494003668 phosphorylation site [posttranslational modification] 1091494003669 intermolecular recognition site; other site 1091494003670 dimerization interface [polypeptide binding]; other site 1091494003671 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003673 metal binding site [ion binding]; metal-binding site 1091494003674 active site 1091494003675 I-site; other site 1091494003676 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1665 1091494003677 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1091494003678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494003679 motif II; other site 1091494003680 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1091494003681 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 1091494003682 Putative D-pathway homolog; other site 1091494003683 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1091494003684 Low-spin heme binding site [chemical binding]; other site 1091494003685 Subunit I/II interface [polypeptide binding]; other site 1091494003686 Putative Q-pathway; other site 1091494003687 Putative alternate electron transfer pathway; other site 1091494003688 Putative water exit pathway; other site 1091494003689 Binuclear center (active site) [active] 1091494003690 Putative K-pathway homolog; other site 1091494003691 Putative proton exit pathway; other site 1091494003692 Subunit I/IIa interface [polypeptide binding]; other site 1091494003693 Electron transfer pathway; other site 1091494003694 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1091494003695 Cytochrome c; Region: Cytochrom_C; cl11414 1091494003696 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1091494003697 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1091494003698 ATP binding site [chemical binding]; other site 1091494003699 substrate interface [chemical binding]; other site 1091494003700 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1091494003701 oligomerisation interface [polypeptide binding]; other site 1091494003702 mobile loop; other site 1091494003703 roof hairpin; other site 1091494003704 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1091494003705 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1091494003706 ring oligomerisation interface [polypeptide binding]; other site 1091494003707 ATP/Mg binding site [chemical binding]; other site 1091494003708 stacking interactions; other site 1091494003709 hinge regions; other site 1091494003710 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 1091494003711 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1091494003712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1091494003713 DNA binding residues [nucleotide binding] 1091494003714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091494003715 Integrase core domain; Region: rve; pfam00665 1091494003716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494003717 Walker A motif; other site 1091494003718 ATP binding site [chemical binding]; other site 1091494003719 Walker B motif; other site 1091494003720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494003721 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494003722 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1091494003723 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1091494003724 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1091494003725 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1091494003726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091494003727 catalytic loop [active] 1091494003728 iron binding site [ion binding]; other site 1091494003729 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1091494003730 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1091494003731 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091494003732 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1091494003733 SLBB domain; Region: SLBB; pfam10531 1091494003734 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1091494003735 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1091494003736 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494003737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494003738 ligand binding site [chemical binding]; other site 1091494003739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494003740 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 1091494003741 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 1091494003742 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 1091494003743 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 1091494003744 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1091494003745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494003746 FeS/SAM binding site; other site 1091494003747 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1091494003748 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1091494003749 dimer interface [polypeptide binding]; other site 1091494003750 putative functional site; other site 1091494003751 putative MPT binding site; other site 1091494003752 Cytochrome c [Energy production and conversion]; Region: COG3258 1091494003753 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1091494003754 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1091494003755 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1091494003756 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1091494003757 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1091494003758 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1091494003759 TPP-binding site; other site 1091494003760 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091494003761 PYR/PP interface [polypeptide binding]; other site 1091494003762 dimer interface [polypeptide binding]; other site 1091494003763 TPP binding site [chemical binding]; other site 1091494003764 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091494003765 Copper resistance protein D; Region: CopD; cl00563 1091494003766 CopC domain; Region: CopC; cl01012 1091494003767 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1091494003768 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494003769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091494003770 MarR family; Region: MarR; pfam01047 1091494003771 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494003772 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494003773 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091494003774 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1091494003775 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091494003776 Ligand Binding Site [chemical binding]; other site 1091494003777 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091494003778 Ligand Binding Site [chemical binding]; other site 1091494003779 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1091494003780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494003781 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1091494003782 inhibitor-cofactor binding pocket; inhibition site 1091494003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494003784 catalytic residue [active] 1091494003785 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091494003786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091494003787 NAD(P) binding site [chemical binding]; other site 1091494003788 active site 1091494003789 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091494003790 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494003791 P-loop; other site 1091494003792 Magnesium ion binding site [ion binding]; other site 1091494003793 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494003794 Magnesium ion binding site [ion binding]; other site 1091494003795 CHAD domain; Region: CHAD; pfam05235 1091494003796 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1091494003797 catalytic core [active] 1091494003798 PBP superfamily domain; Region: PBP_like_2; cl17296 1091494003799 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1091494003800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494003801 dimer interface [polypeptide binding]; other site 1091494003802 conserved gate region; other site 1091494003803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494003804 dimer interface [polypeptide binding]; other site 1091494003805 conserved gate region; other site 1091494003806 putative PBP binding loops; other site 1091494003807 ABC-ATPase subunit interface; other site 1091494003808 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1091494003809 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1091494003810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494003811 dimer interface [polypeptide binding]; other site 1091494003812 conserved gate region; other site 1091494003813 putative PBP binding loops; other site 1091494003814 ABC-ATPase subunit interface; other site 1091494003815 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1091494003816 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1091494003817 Walker A/P-loop; other site 1091494003818 ATP binding site [chemical binding]; other site 1091494003819 Q-loop/lid; other site 1091494003820 ABC transporter signature motif; other site 1091494003821 Walker B; other site 1091494003822 D-loop; other site 1091494003823 H-loop/switch region; other site 1091494003824 transcriptional regulator PhoU; Provisional; Region: PRK11115 1091494003825 PhoU domain; Region: PhoU; pfam01895 1091494003826 PhoU domain; Region: PhoU; pfam01895 1091494003827 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1091494003828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494003829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494003830 DNA binding residues [nucleotide binding] 1091494003831 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1091494003832 Predicted transcriptional regulator [Transcription]; Region: COG2378 1091494003833 WYL domain; Region: WYL; pfam13280 1091494003834 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1091494003835 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1091494003836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091494003837 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1091494003838 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1091494003839 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1091494003840 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1091494003841 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1091494003842 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1091494003843 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1091494003844 L,D-transpeptidase; Provisional; Region: PRK10260 1091494003845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494003846 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1091494003847 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1091494003848 active site 1091494003849 substrate binding site [chemical binding]; other site 1091494003850 cosubstrate binding site; other site 1091494003851 catalytic site [active] 1091494003852 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1091494003853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091494003854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494003855 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494003856 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1091494003857 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091494003858 E3 interaction surface; other site 1091494003859 lipoyl attachment site [posttranslational modification]; other site 1091494003860 e3 binding domain; Region: E3_binding; pfam02817 1091494003861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091494003862 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1091494003863 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1091494003864 dimer interface [polypeptide binding]; other site 1091494003865 TPP-binding site [chemical binding]; other site 1091494003866 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1091494003867 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1091494003868 dimer interface [polypeptide binding]; other site 1091494003869 active site 1091494003870 citrylCoA binding site [chemical binding]; other site 1091494003871 NADH binding [chemical binding]; other site 1091494003872 cationic pore residues; other site 1091494003873 oxalacetate/citrate binding site [chemical binding]; other site 1091494003874 coenzyme A binding site [chemical binding]; other site 1091494003875 catalytic triad [active] 1091494003876 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1091494003877 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1091494003878 active site 1091494003879 intersubunit interface [polypeptide binding]; other site 1091494003880 catalytic residue [active] 1091494003881 phosphogluconate dehydratase; Validated; Region: PRK09054 1091494003882 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1091494003883 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1091494003884 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1091494003885 ATP-grasp domain; Region: ATP-grasp; pfam02222 1091494003886 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1091494003887 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1091494003888 active site 1091494003889 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1091494003890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494003891 ligand binding site [chemical binding]; other site 1091494003892 flagellar motor protein MotP; Reviewed; Region: PRK06926 1091494003893 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494003894 response regulator; Provisional; Region: PRK09483 1091494003895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494003896 active site 1091494003897 phosphorylation site [posttranslational modification] 1091494003898 intermolecular recognition site; other site 1091494003899 dimerization interface [polypeptide binding]; other site 1091494003900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494003901 DNA binding residues [nucleotide binding] 1091494003902 dimerization interface [polypeptide binding]; other site 1091494003903 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 1091494003904 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 1091494003905 NADP binding site [chemical binding]; other site 1091494003906 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 1091494003907 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 1091494003908 NADP binding site [chemical binding]; other site 1091494003909 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1091494003910 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1091494003911 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1091494003912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1091494003913 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494003914 catalytic residue [active] 1091494003915 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1091494003916 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1091494003917 putative NAD(P) binding site [chemical binding]; other site 1091494003918 HDOD domain; Region: HDOD; pfam08668 1091494003919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494003920 Zn2+ binding site [ion binding]; other site 1091494003921 Mg2+ binding site [ion binding]; other site 1091494003922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494003923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494003924 metal binding site [ion binding]; metal-binding site 1091494003925 active site 1091494003926 I-site; other site 1091494003927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494003928 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1091494003929 Transglycosylase; Region: Transgly; pfam00912 1091494003930 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1091494003931 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1091494003932 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1091494003933 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1091494003934 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1091494003935 Cupin; Region: Cupin_6; pfam12852 1091494003936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1091494003937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1091494003938 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1091494003939 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091494003940 mercuric reductase; Validated; Region: PRK06370 1091494003941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494003942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494003943 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494003944 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091494003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494003946 S-adenosylmethionine binding site [chemical binding]; other site 1091494003947 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1091494003948 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1091494003949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494003950 FeS/SAM binding site; other site 1091494003951 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1091494003952 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1091494003953 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1091494003954 Abi-like protein; Region: Abi_2; cl01988 1091494003955 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494003956 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494003957 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1091494003958 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1091494003959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494003960 non-specific DNA binding site [nucleotide binding]; other site 1091494003961 salt bridge; other site 1091494003962 sequence-specific DNA binding site [nucleotide binding]; other site 1091494003963 potential frameshift: common BLAST hit: gi|310830284|ref|YP_003965384.1| type I restriction-modification system endonuclease 1091494003964 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1091494003965 potential frameshift: common BLAST hit: gi|110681178|ref|YP_684185.1| type I restriction-modification system endonuclease 1091494003966 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1091494003967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494003968 ATP binding site [chemical binding]; other site 1091494003969 putative Mg++ binding site [ion binding]; other site 1091494003970 potential frameshift: common BLAST hit: gi|110681178|ref|YP_684185.1| type I restriction-modification system endonuclease 1091494003971 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1091494003972 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 1091494003973 Caspase domain; Region: Peptidase_C14; pfam00656 1091494003974 substrate pocket [chemical binding]; other site 1091494003975 active site 1091494003976 proteolytic cleavage site; other site 1091494003977 dimer interface [polypeptide binding]; other site 1091494003978 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494003979 Sel1-like repeats; Region: SEL1; smart00671 1091494003980 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1091494003981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494003982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494003983 DNA binding residues [nucleotide binding] 1091494003984 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1091494003985 Peptidase family M48; Region: Peptidase_M48; cl12018 1091494003986 Predicted transcriptional regulator [Transcription]; Region: COG2345 1091494003987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494003988 putative Zn2+ binding site [ion binding]; other site 1091494003989 putative DNA binding site [nucleotide binding]; other site 1091494003990 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1091494003991 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 1091494003992 FAD binding pocket [chemical binding]; other site 1091494003993 conserved FAD binding motif [chemical binding]; other site 1091494003994 phosphate binding motif [ion binding]; other site 1091494003995 beta-alpha-beta structure motif; other site 1091494003996 NAD binding pocket [chemical binding]; other site 1091494003997 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1091494003998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091494003999 active site 1091494004000 metal binding site [ion binding]; metal-binding site 1091494004001 ribonuclease R; Region: RNase_R; TIGR02063 1091494004002 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1091494004003 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1091494004004 RNB domain; Region: RNB; pfam00773 1091494004005 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1091494004006 RNA binding site [nucleotide binding]; other site 1091494004007 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1091494004008 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1091494004009 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1091494004010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1091494004011 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494004012 Sel1-like repeats; Region: SEL1; smart00671 1091494004013 Sel1-like repeats; Region: SEL1; smart00671 1091494004014 Caspase domain; Region: Peptidase_C14; pfam00656 1091494004015 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1091494004016 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494004017 Sel1-like repeats; Region: SEL1; smart00671 1091494004018 Sel1-like repeats; Region: SEL1; smart00671 1091494004019 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1091494004020 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494004021 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494004022 catalytic residue [active] 1091494004023 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1091494004024 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1091494004025 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1091494004026 CAP-like domain; other site 1091494004027 active site 1091494004028 primary dimer interface [polypeptide binding]; other site 1091494004029 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 1091494004030 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1091494004031 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1091494004032 homodimer interface [polypeptide binding]; other site 1091494004033 NADP binding site [chemical binding]; other site 1091494004034 substrate binding site [chemical binding]; other site 1091494004035 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 1091494004036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004037 active site 1091494004038 phosphorylation site [posttranslational modification] 1091494004039 intermolecular recognition site; other site 1091494004040 dimerization interface [polypeptide binding]; other site 1091494004041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494004042 Walker A motif; other site 1091494004043 ATP binding site [chemical binding]; other site 1091494004044 Walker B motif; other site 1091494004045 arginine finger; other site 1091494004046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494004047 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1091494004048 GAF domain; Region: GAF_3; pfam13492 1091494004049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004050 dimer interface [polypeptide binding]; other site 1091494004051 phosphorylation site [posttranslational modification] 1091494004052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004053 ATP binding site [chemical binding]; other site 1091494004054 Mg2+ binding site [ion binding]; other site 1091494004055 G-X-G motif; other site 1091494004056 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1091494004057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494004058 TPR motif; other site 1091494004059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494004060 TPR motif; other site 1091494004061 binding surface 1091494004062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494004063 binding surface 1091494004064 TPR motif; other site 1091494004065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494004066 binding surface 1091494004067 TPR motif; other site 1091494004068 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1091494004069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494004070 binding surface 1091494004071 TPR motif; other site 1091494004072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494004073 TPR motif; other site 1091494004074 TPR repeat; Region: TPR_11; pfam13414 1091494004075 binding surface 1091494004076 TPR repeat; Region: TPR_11; pfam13414 1091494004077 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1091494004078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494004079 TPR motif; other site 1091494004080 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1091494004081 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1091494004082 Chain length determinant protein; Region: Wzz; cl15801 1091494004083 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1091494004084 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091494004085 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 1091494004086 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 1091494004087 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 1091494004088 putative active site [active] 1091494004089 putative catalytic site [active] 1091494004090 FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019 1091494004091 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1091494004092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091494004093 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091494004094 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1091494004095 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1091494004096 FAD binding pocket [chemical binding]; other site 1091494004097 FAD binding motif [chemical binding]; other site 1091494004098 phosphate binding motif [ion binding]; other site 1091494004099 beta-alpha-beta structure motif; other site 1091494004100 NAD binding pocket [chemical binding]; other site 1091494004101 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1091494004102 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1091494004103 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1091494004104 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1091494004105 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1091494004106 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1091494004107 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1091494004108 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1091494004109 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1091494004110 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091494004111 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1091494004112 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1091494004113 active site 1091494004114 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1091494004115 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091494004116 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091494004117 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1091494004118 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1091494004119 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004121 active site 1091494004122 phosphorylation site [posttranslational modification] 1091494004123 intermolecular recognition site; other site 1091494004124 dimerization interface [polypeptide binding]; other site 1091494004125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004126 ATP binding site [chemical binding]; other site 1091494004127 Mg2+ binding site [ion binding]; other site 1091494004128 G-X-G motif; other site 1091494004129 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1091494004130 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1091494004131 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1091494004132 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1091494004133 B12 binding site [chemical binding]; other site 1091494004134 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1091494004135 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1091494004136 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 1091494004137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494004138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004139 dimer interface [polypeptide binding]; other site 1091494004140 phosphorylation site [posttranslational modification] 1091494004141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004142 ATP binding site [chemical binding]; other site 1091494004143 Mg2+ binding site [ion binding]; other site 1091494004144 G-X-G motif; other site 1091494004145 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004147 active site 1091494004148 phosphorylation site [posttranslational modification] 1091494004149 intermolecular recognition site; other site 1091494004150 dimerization interface [polypeptide binding]; other site 1091494004151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004152 PAS domain; Region: PAS_9; pfam13426 1091494004153 putative active site [active] 1091494004154 heme pocket [chemical binding]; other site 1091494004155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494004156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494004157 metal binding site [ion binding]; metal-binding site 1091494004158 active site 1091494004159 I-site; other site 1091494004160 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494004161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494004162 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1091494004163 inhibitor-cofactor binding pocket; inhibition site 1091494004164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494004165 catalytic residue [active] 1091494004166 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1091494004167 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494004168 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494004169 protein binding site [polypeptide binding]; other site 1091494004170 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494004171 protein binding site [polypeptide binding]; other site 1091494004172 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1091494004173 Predicted transporter component [General function prediction only]; Region: COG2391 1091494004174 Sulphur transport; Region: Sulf_transp; pfam04143 1091494004175 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1091494004176 Moco binding site; other site 1091494004177 metal coordination site [ion binding]; other site 1091494004178 Cytochrome c; Region: Cytochrom_C; pfam00034 1091494004179 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004181 active site 1091494004182 phosphorylation site [posttranslational modification] 1091494004183 intermolecular recognition site; other site 1091494004184 dimerization interface [polypeptide binding]; other site 1091494004185 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1091494004186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004187 active site 1091494004188 phosphorylation site [posttranslational modification] 1091494004189 intermolecular recognition site; other site 1091494004190 dimerization interface [polypeptide binding]; other site 1091494004191 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 1091494004192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494004193 FeS/SAM binding site; other site 1091494004194 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1091494004195 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1091494004196 Ligand Binding Site [chemical binding]; other site 1091494004197 TilS substrate binding domain; Region: TilS; pfam09179 1091494004198 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1091494004199 CTP synthetase; Validated; Region: pyrG; PRK05380 1091494004200 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1091494004201 Catalytic site [active] 1091494004202 active site 1091494004203 UTP binding site [chemical binding]; other site 1091494004204 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1091494004205 active site 1091494004206 putative oxyanion hole; other site 1091494004207 catalytic triad [active] 1091494004208 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1091494004209 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1091494004210 enolase; Provisional; Region: eno; PRK00077 1091494004211 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1091494004212 dimer interface [polypeptide binding]; other site 1091494004213 metal binding site [ion binding]; metal-binding site 1091494004214 substrate binding pocket [chemical binding]; other site 1091494004215 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1091494004216 Septum formation initiator; Region: DivIC; cl17659 1091494004217 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1091494004218 substrate binding site; other site 1091494004219 dimer interface; other site 1091494004220 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1091494004221 homotrimer interaction site [polypeptide binding]; other site 1091494004222 zinc binding site [ion binding]; other site 1091494004223 CDP-binding sites; other site 1091494004224 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 1091494004225 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1091494004226 Permutation of conserved domain; other site 1091494004227 active site 1091494004228 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1091494004229 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1091494004230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1091494004231 Smr domain; Region: Smr; pfam01713 1091494004232 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1091494004233 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1091494004234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494004235 S-adenosylmethionine binding site [chemical binding]; other site 1091494004236 Predicted membrane protein [Function unknown]; Region: COG1238 1091494004237 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1091494004238 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091494004239 active site 1091494004240 dimer interface [polypeptide binding]; other site 1091494004241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1091494004242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1091494004243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1091494004244 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1091494004245 dimer interface [polypeptide binding]; other site 1091494004246 [2Fe-2S] cluster binding site [ion binding]; other site 1091494004247 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091494004248 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1091494004249 ATP binding site [chemical binding]; other site 1091494004250 Mg++ binding site [ion binding]; other site 1091494004251 motif III; other site 1091494004252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494004253 nucleotide binding region [chemical binding]; other site 1091494004254 ATP-binding site [chemical binding]; other site 1091494004255 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1091494004256 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1091494004257 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091494004258 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1091494004259 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1091494004260 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1091494004261 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1091494004262 active site 1091494004263 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1091494004264 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1091494004265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494004266 catalytic residue [active] 1091494004267 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1091494004268 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1091494004269 substrate binding site [chemical binding]; other site 1091494004270 active site 1091494004271 catalytic residues [active] 1091494004272 heterodimer interface [polypeptide binding]; other site 1091494004273 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1091494004274 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1091494004275 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494004276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1091494004277 Sporulation related domain; Region: SPOR; pfam05036 1091494004278 Sporulation related domain; Region: SPOR; pfam05036 1091494004279 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1091494004280 Colicin V production protein; Region: Colicin_V; pfam02674 1091494004281 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1091494004282 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1091494004283 active site 1091494004284 tetramer interface [polypeptide binding]; other site 1091494004285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494004286 active site 1091494004287 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1091494004288 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1091494004289 homodimer interface [polypeptide binding]; other site 1091494004290 substrate-cofactor binding pocket; other site 1091494004291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494004292 catalytic residue [active] 1091494004293 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1091494004294 putative hydrophobic ligand binding site [chemical binding]; other site 1091494004295 protein interface [polypeptide binding]; other site 1091494004296 gate; other site 1091494004297 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1091494004298 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004299 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004300 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004301 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004302 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004303 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494004304 Domain of unknown function DUF59; Region: DUF59; cl00941 1091494004305 short chain dehydrogenase; Provisional; Region: PRK06138 1091494004306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091494004307 NAD(P) binding site [chemical binding]; other site 1091494004308 active site 1091494004309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1091494004310 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1091494004311 motif I; other site 1091494004312 active site 1091494004313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494004314 motif II; other site 1091494004315 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1091494004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494004317 S-adenosylmethionine binding site [chemical binding]; other site 1091494004318 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1091494004319 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1091494004320 active site 1091494004321 putative substrate binding pocket [chemical binding]; other site 1091494004322 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1091494004323 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1091494004324 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1091494004325 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1091494004326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494004327 membrane-bound complex binding site; other site 1091494004328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004329 PAS domain; Region: PAS_9; pfam13426 1091494004330 putative active site [active] 1091494004331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004332 PAS domain; Region: PAS_9; pfam13426 1091494004333 putative active site [active] 1091494004334 heme pocket [chemical binding]; other site 1091494004335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494004336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004337 PAS fold; Region: PAS_3; pfam08447 1091494004338 putative active site [active] 1091494004339 heme pocket [chemical binding]; other site 1091494004340 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494004341 GAF domain; Region: GAF; pfam01590 1091494004342 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004344 putative active site [active] 1091494004345 heme pocket [chemical binding]; other site 1091494004346 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1091494004347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494004348 Zn2+ binding site [ion binding]; other site 1091494004349 Mg2+ binding site [ion binding]; other site 1091494004350 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091494004351 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1091494004352 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1091494004353 active site 1091494004354 catalytic site [active] 1091494004355 tartrate dehydrogenase; Region: TTC; TIGR02089 1091494004356 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1091494004357 (R)-citramalate synthase; Provisional; Region: PRK09389 1091494004358 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 1091494004359 active site 1091494004360 catalytic residues [active] 1091494004361 metal binding site [ion binding]; metal-binding site 1091494004362 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1091494004363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494004364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494004365 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494004366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004367 putative active site [active] 1091494004368 heme pocket [chemical binding]; other site 1091494004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004370 dimer interface [polypeptide binding]; other site 1091494004371 phosphorylation site [posttranslational modification] 1091494004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004373 ATP binding site [chemical binding]; other site 1091494004374 Mg2+ binding site [ion binding]; other site 1091494004375 G-X-G motif; other site 1091494004376 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494004377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004378 active site 1091494004379 phosphorylation site [posttranslational modification] 1091494004380 intermolecular recognition site; other site 1091494004381 dimerization interface [polypeptide binding]; other site 1091494004382 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004384 active site 1091494004385 phosphorylation site [posttranslational modification] 1091494004386 intermolecular recognition site; other site 1091494004387 dimerization interface [polypeptide binding]; other site 1091494004388 Hpt domain; Region: Hpt; pfam01627 1091494004389 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494004390 siroheme synthase; Provisional; Region: cysG; PRK10637 1091494004391 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1091494004392 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1091494004393 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1091494004394 active site 1091494004395 SAM binding site [chemical binding]; other site 1091494004396 homodimer interface [polypeptide binding]; other site 1091494004397 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1091494004398 dimer interface [polypeptide binding]; other site 1091494004399 [2Fe-2S] cluster binding site [ion binding]; other site 1091494004400 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1091494004401 active site 1091494004402 SAM binding site [chemical binding]; other site 1091494004403 homodimer interface [polypeptide binding]; other site 1091494004404 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1091494004405 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1091494004406 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1091494004407 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1091494004408 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1091494004409 active site 1091494004410 SAM binding site [chemical binding]; other site 1091494004411 homodimer interface [polypeptide binding]; other site 1091494004412 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1091494004413 active site 1091494004414 putative homodimer interface [polypeptide binding]; other site 1091494004415 SAM binding site [chemical binding]; other site 1091494004416 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1091494004417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494004418 S-adenosylmethionine binding site [chemical binding]; other site 1091494004419 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1091494004420 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1091494004421 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1091494004422 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1091494004423 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1091494004424 putative active site [active] 1091494004425 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1091494004426 putative active site [active] 1091494004427 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1091494004428 active site 1091494004429 SAM binding site [chemical binding]; other site 1091494004430 homodimer interface [polypeptide binding]; other site 1091494004431 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1091494004432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1091494004433 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1091494004434 catalytic triad [active] 1091494004435 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1091494004436 acyl-CoA synthetase; Validated; Region: PRK05850 1091494004437 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1091494004438 acyl-activating enzyme (AAE) consensus motif; other site 1091494004439 active site 1091494004440 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1091494004441 Condensation domain; Region: Condensation; pfam00668 1091494004442 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091494004443 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1091494004444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494004445 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1091494004446 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1091494004447 acyl-activating enzyme (AAE) consensus motif; other site 1091494004448 AMP binding site [chemical binding]; other site 1091494004449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091494004450 Condensation domain; Region: Condensation; pfam00668 1091494004451 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091494004452 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1091494004453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1091494004454 acyl-activating enzyme (AAE) consensus motif; other site 1091494004455 AMP binding site [chemical binding]; other site 1091494004456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091494004457 Condensation domain; Region: Condensation; pfam00668 1091494004458 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1091494004459 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1091494004460 acyl-activating enzyme (AAE) consensus motif; other site 1091494004461 AMP binding site [chemical binding]; other site 1091494004462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1091494004463 thioester reductase domain; Region: Thioester-redct; TIGR01746 1091494004464 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1091494004465 putative NAD(P) binding site [chemical binding]; other site 1091494004466 active site 1091494004467 putative substrate binding site [chemical binding]; other site 1091494004468 Secretin and TonB N terminus short domain; Region: STN; smart00965 1091494004469 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1091494004470 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1091494004471 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494004472 N-terminal plug; other site 1091494004473 ligand-binding site [chemical binding]; other site 1091494004474 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1091494004475 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1091494004476 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091494004477 Cupin-like domain; Region: Cupin_8; pfam13621 1091494004478 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1091494004479 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1091494004480 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1091494004481 Predicted transcriptional regulator [Transcription]; Region: COG4190 1091494004482 MarR family; Region: MarR_2; cl17246 1091494004483 MbtH-like protein; Region: MbtH; cl01279 1091494004484 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1091494004485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494004486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494004487 DNA binding residues [nucleotide binding] 1091494004488 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1091494004489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494004490 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1091494004491 Walker A/P-loop; other site 1091494004492 ATP binding site [chemical binding]; other site 1091494004493 Q-loop/lid; other site 1091494004494 ABC transporter signature motif; other site 1091494004495 Walker B; other site 1091494004496 D-loop; other site 1091494004497 H-loop/switch region; other site 1091494004498 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1091494004499 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1091494004500 active site 1091494004501 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1091494004502 FecR protein; Region: FecR; pfam04773 1091494004503 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1091494004504 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1091494004505 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494004506 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494004507 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1091494004508 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494004509 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1091494004510 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1091494004511 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1091494004512 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494004513 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1091494004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494004515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091494004516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494004517 HDOD domain; Region: HDOD; pfam08668 1091494004518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1091494004519 HemK family putative methylases; Region: hemK_fam; TIGR00536 1091494004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494004521 S-adenosylmethionine binding site [chemical binding]; other site 1091494004522 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1091494004523 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1091494004524 Tetramer interface [polypeptide binding]; other site 1091494004525 active site 1091494004526 FMN-binding site [chemical binding]; other site 1091494004527 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1091494004528 MFS_1 like family; Region: MFS_1_like; pfam12832 1091494004529 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1091494004530 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494004531 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1091494004532 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1091494004533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1091494004534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091494004535 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1091494004536 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1091494004537 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1091494004538 Ligand binding site; other site 1091494004539 oligomer interface; other site 1091494004540 aminotransferase; Validated; Region: PRK08175 1091494004541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494004542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494004543 homodimer interface [polypeptide binding]; other site 1091494004544 catalytic residue [active] 1091494004545 homoserine dehydrogenase; Provisional; Region: PRK06349 1091494004546 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1091494004547 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1091494004548 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1091494004549 threonine synthase; Reviewed; Region: PRK06721 1091494004550 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1091494004551 homodimer interface [polypeptide binding]; other site 1091494004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494004553 catalytic residue [active] 1091494004554 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1091494004555 DHH family; Region: DHH; pfam01368 1091494004556 DHHA1 domain; Region: DHHA1; pfam02272 1091494004557 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1091494004558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494004559 putative carbohydrate kinase; Provisional; Region: PRK10565 1091494004560 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1091494004561 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1091494004562 putative substrate binding site [chemical binding]; other site 1091494004563 putative ATP binding site [chemical binding]; other site 1091494004564 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1091494004565 AMIN domain; Region: AMIN; pfam11741 1091494004566 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1091494004567 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1091494004568 active site 1091494004569 metal binding site [ion binding]; metal-binding site 1091494004570 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494004571 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1091494004572 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1091494004573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004574 ATP binding site [chemical binding]; other site 1091494004575 Mg2+ binding site [ion binding]; other site 1091494004576 G-X-G motif; other site 1091494004577 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1091494004578 ATP binding site [chemical binding]; other site 1091494004579 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1091494004580 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1091494004581 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1091494004582 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1091494004583 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1091494004584 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1091494004585 GTP/Mg2+ binding site [chemical binding]; other site 1091494004586 G4 box; other site 1091494004587 G5 box; other site 1091494004588 G1 box; other site 1091494004589 Switch I region; other site 1091494004590 G2 box; other site 1091494004591 G3 box; other site 1091494004592 Switch II region; other site 1091494004593 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1091494004594 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1091494004595 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1091494004596 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1091494004597 YcfA-like protein; Region: YcfA; cl00752 1091494004598 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1091494004599 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1091494004600 NAD(P) binding site [chemical binding]; other site 1091494004601 catalytic residues [active] 1091494004602 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1091494004603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494004604 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494004605 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1091494004606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091494004607 E3 interaction surface; other site 1091494004608 lipoyl attachment site [posttranslational modification]; other site 1091494004609 e3 binding domain; Region: E3_binding; pfam02817 1091494004610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1091494004611 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1091494004612 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1091494004613 TPP-binding site [chemical binding]; other site 1091494004614 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1091494004615 PYR/PP interface [polypeptide binding]; other site 1091494004616 dimer interface [polypeptide binding]; other site 1091494004617 TPP binding site [chemical binding]; other site 1091494004618 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1091494004619 H-NS histone family; Region: Histone_HNS; pfam00816 1091494004620 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1091494004621 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1091494004622 active site residue [active] 1091494004623 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1091494004624 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1091494004625 dimer interface [polypeptide binding]; other site 1091494004626 putative functional site; other site 1091494004627 putative MPT binding site; other site 1091494004628 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1091494004629 Walker A motif; other site 1091494004630 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494004631 HSP70 interaction site [polypeptide binding]; other site 1091494004632 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1091494004633 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494004634 Peptidase family M23; Region: Peptidase_M23; pfam01551 1091494004635 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1091494004636 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1091494004637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494004638 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091494004639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494004640 DNA binding residues [nucleotide binding] 1091494004641 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1091494004642 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1091494004643 putative active site [active] 1091494004644 catalytic triad [active] 1091494004645 putative dimer interface [polypeptide binding]; other site 1091494004646 Predicted integral membrane protein [Function unknown]; Region: COG5652 1091494004647 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1091494004648 dinuclear metal binding motif [ion binding]; other site 1091494004649 NnrS protein; Region: NnrS; pfam05940 1091494004650 hypothetical protein; Provisional; Region: PRK11281 1091494004651 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1091494004652 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091494004653 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1091494004654 DctM-like transporters; Region: DctM; pfam06808 1091494004655 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1091494004656 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1091494004657 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1091494004658 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091494004659 active site 1091494004660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1091494004661 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 1091494004662 active site 1091494004663 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1091494004664 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1091494004665 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1091494004666 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1091494004667 putative NADP binding site [chemical binding]; other site 1091494004668 active site 1091494004669 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1091494004670 Family description; Region: VCBS; pfam13517 1091494004671 FG-GAP repeat; Region: FG-GAP; pfam01839 1091494004672 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1091494004673 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1091494004674 PEP-CTERM motif; Region: VPEP; pfam07589 1091494004675 Homeodomain-like domain; Region: HTH_23; pfam13384 1091494004676 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494004677 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494004678 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1091494004679 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494004680 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1091494004681 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1091494004682 DNA binding site [nucleotide binding] 1091494004683 catalytic residue [active] 1091494004684 H2TH interface [polypeptide binding]; other site 1091494004685 putative catalytic residues [active] 1091494004686 turnover-facilitating residue; other site 1091494004687 intercalation triad [nucleotide binding]; other site 1091494004688 8OG recognition residue [nucleotide binding]; other site 1091494004689 putative reading head residues; other site 1091494004690 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1091494004691 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091494004692 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1091494004693 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1091494004694 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1091494004695 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1091494004696 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1091494004697 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091494004698 transmembrane helices; other site 1091494004699 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1091494004700 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1091494004701 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1091494004702 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1091494004703 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1091494004704 Walker A/P-loop; other site 1091494004705 ATP binding site [chemical binding]; other site 1091494004706 Q-loop/lid; other site 1091494004707 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1091494004708 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1091494004709 Q-loop/lid; other site 1091494004710 ABC transporter signature motif; other site 1091494004711 Walker B; other site 1091494004712 D-loop; other site 1091494004713 H-loop/switch region; other site 1091494004714 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1091494004715 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1091494004716 FtsZ protein binding site [polypeptide binding]; other site 1091494004717 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1091494004718 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1091494004719 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1091494004720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494004721 catalytic residue [active] 1091494004722 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091494004723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494004724 S-adenosylmethionine binding site [chemical binding]; other site 1091494004725 polyphosphate kinase; Provisional; Region: PRK05443 1091494004726 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1091494004727 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1091494004728 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1091494004729 putative active site [active] 1091494004730 catalytic site [active] 1091494004731 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1091494004732 putative domain interface [polypeptide binding]; other site 1091494004733 putative active site [active] 1091494004734 catalytic site [active] 1091494004735 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1091494004736 dihydropteroate synthase; Region: DHPS; TIGR01496 1091494004737 substrate binding pocket [chemical binding]; other site 1091494004738 dimer interface [polypeptide binding]; other site 1091494004739 inhibitor binding site; inhibition site 1091494004740 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 1091494004741 Flavoprotein; Region: Flavoprotein; pfam02441 1091494004742 dihydropteroate synthase-related protein; Region: TIGR00284 1091494004743 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1091494004744 substrate binding pocket [chemical binding]; other site 1091494004745 dimer interface [polypeptide binding]; other site 1091494004746 inhibitor binding site; inhibition site 1091494004747 Protein of unknown function (DUF447); Region: DUF447; pfam04289 1091494004748 hypothetical protein; Provisional; Region: PRK02227 1091494004749 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1091494004750 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1091494004751 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 1091494004752 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1091494004753 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1091494004754 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 1091494004755 nucleotide binding pocket [chemical binding]; other site 1091494004756 K-X-D-G motif; other site 1091494004757 catalytic site [active] 1091494004758 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1091494004759 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1091494004760 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1091494004761 Dimer interface [polypeptide binding]; other site 1091494004762 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494004763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004764 active site 1091494004765 phosphorylation site [posttranslational modification] 1091494004766 intermolecular recognition site; other site 1091494004767 dimerization interface [polypeptide binding]; other site 1091494004768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494004769 Zn2+ binding site [ion binding]; other site 1091494004770 Mg2+ binding site [ion binding]; other site 1091494004771 PAS fold; Region: PAS_4; pfam08448 1091494004772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004773 putative active site [active] 1091494004774 heme pocket [chemical binding]; other site 1091494004775 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004777 putative active site [active] 1091494004778 heme pocket [chemical binding]; other site 1091494004779 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004781 putative active site [active] 1091494004782 heme pocket [chemical binding]; other site 1091494004783 PAS fold; Region: PAS_4; pfam08448 1091494004784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004785 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494004786 putative active site [active] 1091494004787 heme pocket [chemical binding]; other site 1091494004788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004789 dimer interface [polypeptide binding]; other site 1091494004790 phosphorylation site [posttranslational modification] 1091494004791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004792 ATP binding site [chemical binding]; other site 1091494004793 Mg2+ binding site [ion binding]; other site 1091494004794 G-X-G motif; other site 1091494004795 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494004796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004797 active site 1091494004798 phosphorylation site [posttranslational modification] 1091494004799 intermolecular recognition site; other site 1091494004800 dimerization interface [polypeptide binding]; other site 1091494004801 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004802 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004803 putative active site [active] 1091494004804 heme pocket [chemical binding]; other site 1091494004805 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004807 putative active site [active] 1091494004808 heme pocket [chemical binding]; other site 1091494004809 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494004810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004811 putative active site [active] 1091494004812 heme pocket [chemical binding]; other site 1091494004813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004814 dimer interface [polypeptide binding]; other site 1091494004815 phosphorylation site [posttranslational modification] 1091494004816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004817 ATP binding site [chemical binding]; other site 1091494004818 Mg2+ binding site [ion binding]; other site 1091494004819 G-X-G motif; other site 1091494004820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004821 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004822 active site 1091494004823 phosphorylation site [posttranslational modification] 1091494004824 intermolecular recognition site; other site 1091494004825 dimerization interface [polypeptide binding]; other site 1091494004826 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1091494004827 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494004828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494004829 active site 1091494004830 phosphorylation site [posttranslational modification] 1091494004831 intermolecular recognition site; other site 1091494004832 dimerization interface [polypeptide binding]; other site 1091494004833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494004834 dimer interface [polypeptide binding]; other site 1091494004835 phosphorylation site [posttranslational modification] 1091494004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494004837 ATP binding site [chemical binding]; other site 1091494004838 Mg2+ binding site [ion binding]; other site 1091494004839 G-X-G motif; other site 1091494004840 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1091494004841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494004842 Walker A/P-loop; other site 1091494004843 ATP binding site [chemical binding]; other site 1091494004844 Q-loop/lid; other site 1091494004845 ABC transporter signature motif; other site 1091494004846 Walker B; other site 1091494004847 D-loop; other site 1091494004848 H-loop/switch region; other site 1091494004849 putative lysogenization regulator; Reviewed; Region: PRK00218 1091494004850 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494004851 active site residue [active] 1091494004852 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1091494004853 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494004854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091494004855 metal-binding site [ion binding] 1091494004856 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091494004857 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091494004858 metal-binding site [ion binding] 1091494004859 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494004860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494004861 motif II; other site 1091494004862 PAS fold; Region: PAS; pfam00989 1091494004863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004864 putative active site [active] 1091494004865 heme pocket [chemical binding]; other site 1091494004866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494004867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494004868 metal binding site [ion binding]; metal-binding site 1091494004869 active site 1091494004870 I-site; other site 1091494004871 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494004872 Protein of unknown function, DUF484; Region: DUF484; cl17449 1091494004873 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494004874 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494004875 metal binding site [ion binding]; metal-binding site 1091494004876 active site 1091494004877 I-site; other site 1091494004878 V-type ATP synthase subunit B; Provisional; Region: PRK02118 1091494004879 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494004880 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1091494004881 Walker A motif homologous position; other site 1091494004882 Walker B motif; other site 1091494004883 ATP synthase subunit D; Region: ATP-synt_D; cl00613 1091494004884 V-type ATP synthase subunit I; Validated; Region: PRK05771 1091494004885 V-type ATP synthase subunit K; Provisional; Region: PRK09621 1091494004886 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1091494004887 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1091494004888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494004889 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1091494004890 Walker A motif/ATP binding site; other site 1091494004891 Walker B motif; other site 1091494004892 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1091494004893 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1091494004894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494004895 dimerization interface [polypeptide binding]; other site 1091494004896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494004897 dimer interface [polypeptide binding]; other site 1091494004898 putative CheW interface [polypeptide binding]; other site 1091494004899 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1091494004900 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1091494004901 active site 1091494004902 Dienelactone hydrolase family; Region: DLH; pfam01738 1091494004903 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1091494004904 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1091494004905 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1091494004906 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1091494004907 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1091494004908 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1091494004909 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1091494004910 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091494004911 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1091494004912 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1091494004913 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494004914 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1091494004915 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494004916 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1091494004917 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1091494004918 4-coumarate--CoA ligase, photoactive yellow protein activation family; Region: 4_coum_CoA_lig; TIGR02372 1091494004919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494004920 active site 1091494004921 CoA binding site [chemical binding]; other site 1091494004922 AMP binding site [chemical binding]; other site 1091494004923 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494004924 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494004925 dimer interface [polypeptide binding]; other site 1091494004926 putative CheW interface [polypeptide binding]; other site 1091494004927 PAS fold; Region: PAS; pfam00989 1091494004928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004929 putative active site [active] 1091494004930 heme pocket [chemical binding]; other site 1091494004931 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1091494004932 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1091494004933 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091494004934 Cysteine-rich domain; Region: CCG; pfam02754 1091494004935 Cysteine-rich domain; Region: CCG; pfam02754 1091494004936 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1091494004937 FAD binding domain; Region: FAD_binding_4; pfam01565 1091494004938 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1091494004939 FAD binding domain; Region: FAD_binding_4; pfam01565 1091494004940 Cupin domain; Region: Cupin_2; cl17218 1091494004941 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1091494004942 Predicted membrane protein [Function unknown]; Region: COG3431 1091494004943 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494004944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494004945 ligand binding site [chemical binding]; other site 1091494004946 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1091494004947 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1091494004948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091494004949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091494004950 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1091494004951 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1091494004952 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1091494004953 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1091494004954 putative active site [active] 1091494004955 putative active site [active] 1091494004956 catalytic site [active] 1091494004957 catalytic site [active] 1091494004958 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1091494004959 putative active site [active] 1091494004960 catalytic site [active] 1091494004961 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1091494004962 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091494004963 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1091494004964 putative catalytic site [active] 1091494004965 putative metal binding site [ion binding]; other site 1091494004966 putative phosphate binding site [ion binding]; other site 1091494004967 BON domain; Region: BON; pfam04972 1091494004968 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091494004969 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091494004970 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1091494004971 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 1091494004972 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1091494004973 active site 1091494004974 catalytic site [active] 1091494004975 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1091494004976 ATP-binding site [chemical binding]; other site 1091494004977 Gluconate-6-phosphate binding site [chemical binding]; other site 1091494004978 Shikimate kinase; Region: SKI; pfam01202 1091494004979 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1091494004980 Strictosidine synthase; Region: Str_synth; pfam03088 1091494004981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 1091494004982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1091494004983 circadian clock protein KaiC; Reviewed; Region: PRK09302 1091494004984 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494004985 ATP binding site [chemical binding]; other site 1091494004986 Walker A motif; other site 1091494004987 Walker B motif; other site 1091494004988 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494004989 Walker A motif; other site 1091494004990 ATP binding site [chemical binding]; other site 1091494004991 Walker B motif; other site 1091494004992 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1091494004993 tetramer interface [polypeptide binding]; other site 1091494004994 dimer interface [polypeptide binding]; other site 1091494004995 PAS fold; Region: PAS_4; pfam08448 1091494004996 PAS domain S-box; Region: sensory_box; TIGR00229 1091494004997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494004998 putative active site [active] 1091494004999 heme pocket [chemical binding]; other site 1091494005000 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494005001 GAF domain; Region: GAF; pfam01590 1091494005002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494005003 metal binding site [ion binding]; metal-binding site 1091494005004 active site 1091494005005 I-site; other site 1091494005006 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494005007 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1091494005008 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1091494005009 NAD binding site [chemical binding]; other site 1091494005010 homodimer interface [polypeptide binding]; other site 1091494005011 active site 1091494005012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091494005013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005014 active site 1091494005015 phosphorylation site [posttranslational modification] 1091494005016 intermolecular recognition site; other site 1091494005017 dimerization interface [polypeptide binding]; other site 1091494005018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494005019 DNA binding site [nucleotide binding] 1091494005020 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1091494005021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494005022 dimerization interface [polypeptide binding]; other site 1091494005023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494005024 dimer interface [polypeptide binding]; other site 1091494005025 phosphorylation site [posttranslational modification] 1091494005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494005027 ATP binding site [chemical binding]; other site 1091494005028 Mg2+ binding site [ion binding]; other site 1091494005029 G-X-G motif; other site 1091494005030 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1091494005031 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1091494005032 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1091494005033 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1091494005034 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1091494005035 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1091494005036 putative active site [active] 1091494005037 Zn binding site [ion binding]; other site 1091494005038 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1091494005039 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1091494005040 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091494005041 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1091494005042 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091494005043 active site 1091494005044 metal binding site [ion binding]; metal-binding site 1091494005045 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091494005046 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1091494005047 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1091494005048 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1091494005049 epoxyqueuosine reductase; Region: TIGR00276 1091494005050 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1091494005051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494005052 TPR motif; other site 1091494005053 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1091494005054 binding surface 1091494005055 HDOD domain; Region: HDOD; pfam08668 1091494005056 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1091494005057 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494005058 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091494005059 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1091494005060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005061 S-adenosylmethionine binding site [chemical binding]; other site 1091494005062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005063 S-adenosylmethionine binding site [chemical binding]; other site 1091494005064 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1091494005065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494005066 FeS/SAM binding site; other site 1091494005067 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1091494005068 Na2 binding site [ion binding]; other site 1091494005069 putative substrate binding site 1 [chemical binding]; other site 1091494005070 Na binding site 1 [ion binding]; other site 1091494005071 putative substrate binding site 2 [chemical binding]; other site 1091494005072 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1091494005073 GSH binding site [chemical binding]; other site 1091494005074 catalytic residues [active] 1091494005075 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1091494005076 active site 1091494005077 intersubunit interface [polypeptide binding]; other site 1091494005078 Zn2+ binding site [ion binding]; other site 1091494005079 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1091494005080 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1091494005081 heme binding site [chemical binding]; other site 1091494005082 ferroxidase pore; other site 1091494005083 ferroxidase diiron center [ion binding]; other site 1091494005084 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1091494005085 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1091494005086 Proline dehydrogenase; Region: Pro_dh; pfam01619 1091494005087 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1091494005088 Glutamate binding site [chemical binding]; other site 1091494005089 NAD binding site [chemical binding]; other site 1091494005090 catalytic residues [active] 1091494005091 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1091494005092 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494005093 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1091494005094 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1091494005095 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091494005096 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1091494005097 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1091494005098 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494005099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005100 active site 1091494005101 phosphorylation site [posttranslational modification] 1091494005102 intermolecular recognition site; other site 1091494005103 dimerization interface [polypeptide binding]; other site 1091494005104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494005105 DNA binding residues [nucleotide binding] 1091494005106 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1091494005107 Na binding site [ion binding]; other site 1091494005108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494005109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494005110 dimer interface [polypeptide binding]; other site 1091494005111 phosphorylation site [posttranslational modification] 1091494005112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494005113 ATP binding site [chemical binding]; other site 1091494005114 Mg2+ binding site [ion binding]; other site 1091494005115 G-X-G motif; other site 1091494005116 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494005117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005118 active site 1091494005119 phosphorylation site [posttranslational modification] 1091494005120 intermolecular recognition site; other site 1091494005121 dimerization interface [polypeptide binding]; other site 1091494005122 SdiA-regulated; Region: SdiA-regulated; pfam06977 1091494005123 SdiA-regulated; Region: SdiA-regulated; cd09971 1091494005124 putative active site [active] 1091494005125 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494005126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005127 active site 1091494005128 phosphorylation site [posttranslational modification] 1091494005129 intermolecular recognition site; other site 1091494005130 dimerization interface [polypeptide binding]; other site 1091494005131 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494005132 DNA binding residues [nucleotide binding] 1091494005133 dimerization interface [polypeptide binding]; other site 1091494005134 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1091494005135 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1091494005136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494005137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494005138 dimer interface [polypeptide binding]; other site 1091494005139 phosphorylation site [posttranslational modification] 1091494005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494005141 ATP binding site [chemical binding]; other site 1091494005142 Mg2+ binding site [ion binding]; other site 1091494005143 G-X-G motif; other site 1091494005144 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005146 active site 1091494005147 phosphorylation site [posttranslational modification] 1091494005148 intermolecular recognition site; other site 1091494005149 dimerization interface [polypeptide binding]; other site 1091494005150 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494005151 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1091494005152 putative ligand binding site [chemical binding]; other site 1091494005153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1091494005154 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1091494005155 TM-ABC transporter signature motif; other site 1091494005156 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1091494005157 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1091494005158 TM-ABC transporter signature motif; other site 1091494005159 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1091494005160 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1091494005161 Walker A/P-loop; other site 1091494005162 ATP binding site [chemical binding]; other site 1091494005163 Q-loop/lid; other site 1091494005164 ABC transporter signature motif; other site 1091494005165 Walker B; other site 1091494005166 D-loop; other site 1091494005167 H-loop/switch region; other site 1091494005168 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1091494005169 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1091494005170 Walker A/P-loop; other site 1091494005171 ATP binding site [chemical binding]; other site 1091494005172 Q-loop/lid; other site 1091494005173 ABC transporter signature motif; other site 1091494005174 Walker B; other site 1091494005175 D-loop; other site 1091494005176 H-loop/switch region; other site 1091494005177 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1091494005178 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1091494005179 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1091494005180 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1091494005181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494005182 non-specific DNA binding site [nucleotide binding]; other site 1091494005183 salt bridge; other site 1091494005184 sequence-specific DNA binding site [nucleotide binding]; other site 1091494005185 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1091494005186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1091494005187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1091494005188 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494005189 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 1091494005190 potential frameshift: common BLAST hit: gi|344200426|ref|YP_004784752.1| transposase IS204/IS1001/IS1096/IS1165 family protein 1091494005191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494005192 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494005193 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1091494005194 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494005195 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1091494005196 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1091494005197 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1091494005198 TM-ABC transporter signature motif; other site 1091494005199 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1091494005200 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1091494005201 TM-ABC transporter signature motif; other site 1091494005202 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1091494005203 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1091494005204 Walker A/P-loop; other site 1091494005205 ATP binding site [chemical binding]; other site 1091494005206 Q-loop/lid; other site 1091494005207 ABC transporter signature motif; other site 1091494005208 Walker B; other site 1091494005209 D-loop; other site 1091494005210 H-loop/switch region; other site 1091494005211 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1091494005212 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1091494005213 Walker A/P-loop; other site 1091494005214 ATP binding site [chemical binding]; other site 1091494005215 Q-loop/lid; other site 1091494005216 ABC transporter signature motif; other site 1091494005217 Walker B; other site 1091494005218 D-loop; other site 1091494005219 H-loop/switch region; other site 1091494005220 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1091494005221 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1091494005222 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1091494005223 alpha-gamma subunit interface [polypeptide binding]; other site 1091494005224 beta-gamma subunit interface [polypeptide binding]; other site 1091494005225 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1091494005226 gamma-beta subunit interface [polypeptide binding]; other site 1091494005227 alpha-beta subunit interface [polypeptide binding]; other site 1091494005228 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1091494005229 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1091494005230 subunit interactions [polypeptide binding]; other site 1091494005231 active site 1091494005232 flap region; other site 1091494005233 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1091494005234 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1091494005235 dimer interface [polypeptide binding]; other site 1091494005236 catalytic residues [active] 1091494005237 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1091494005238 UreF; Region: UreF; pfam01730 1091494005239 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091494005240 G1 box; other site 1091494005241 GTP/Mg2+ binding site [chemical binding]; other site 1091494005242 G2 box; other site 1091494005243 Switch I region; other site 1091494005244 G3 box; other site 1091494005245 Switch II region; other site 1091494005246 G4 box; other site 1091494005247 G5 box; other site 1091494005248 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1091494005249 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1091494005250 dimer interface [polypeptide binding]; other site 1091494005251 active site 1091494005252 catalytic residue [active] 1091494005253 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1091494005254 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1091494005255 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1091494005256 dimerization interface [polypeptide binding]; other site 1091494005257 ATP binding site [chemical binding]; other site 1091494005258 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1091494005259 dimerization interface [polypeptide binding]; other site 1091494005260 ATP binding site [chemical binding]; other site 1091494005261 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1091494005262 putative active site [active] 1091494005263 catalytic triad [active] 1091494005264 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1091494005265 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1091494005266 putative dimer interface [polypeptide binding]; other site 1091494005267 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1091494005268 integron integrase; Region: integrase_gron; TIGR02249 1091494005269 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1091494005270 Int/Topo IB signature motif; other site 1091494005271 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1091494005272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494005273 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494005274 active site 1091494005275 ATP binding site [chemical binding]; other site 1091494005276 substrate binding site [chemical binding]; other site 1091494005277 activation loop (A-loop); other site 1091494005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 1091494005279 Haem-binding domain; Region: Haem_bd; pfam14376 1091494005280 Transposase IS200 like; Region: Y1_Tnp; cl00848 1091494005281 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1091494005282 putative active site pocket [active] 1091494005283 dimerization interface [polypeptide binding]; other site 1091494005284 putative catalytic residue [active] 1091494005285 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1091494005286 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1091494005287 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1091494005288 putative active site [active] 1091494005289 Ap4A binding site [chemical binding]; other site 1091494005290 nudix motif; other site 1091494005291 putative metal binding site [ion binding]; other site 1091494005292 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1091494005293 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1091494005294 hexamer interface [polypeptide binding]; other site 1091494005295 active site 1091494005296 metal binding site [ion binding]; metal-binding site 1091494005297 N-acetylglutamate synthase; Validated; Region: PRK05279 1091494005298 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1091494005299 putative feedback inhibition sensing region; other site 1091494005300 putative nucleotide binding site [chemical binding]; other site 1091494005301 putative substrate binding site [chemical binding]; other site 1091494005302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091494005303 Coenzyme A binding pocket [chemical binding]; other site 1091494005304 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1091494005305 Bacterial SH3 domain; Region: SH3_3; cl17532 1091494005306 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1091494005307 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1091494005308 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1091494005309 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1091494005310 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1091494005311 acetylornithine aminotransferase; Provisional; Region: PRK02627 1091494005312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494005313 inhibitor-cofactor binding pocket; inhibition site 1091494005314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494005315 catalytic residue [active] 1091494005316 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1091494005317 putative GSH binding site [chemical binding]; other site 1091494005318 catalytic residues [active] 1091494005319 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1091494005320 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1091494005321 dimer interface [polypeptide binding]; other site 1091494005322 catalytic site [active] 1091494005323 putative active site [active] 1091494005324 putative substrate binding site [chemical binding]; other site 1091494005325 VacJ like lipoprotein; Region: VacJ; cl01073 1091494005326 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1091494005327 Predicted flavoprotein [General function prediction only]; Region: COG0431 1091494005328 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1091494005329 Transglycosylase; Region: Transgly; cl17702 1091494005330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1091494005331 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1091494005332 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1091494005333 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1091494005334 catalytic site [active] 1091494005335 subunit interface [polypeptide binding]; other site 1091494005336 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1091494005337 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091494005338 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091494005339 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1091494005340 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091494005341 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494005342 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1091494005343 IMP binding site; other site 1091494005344 dimer interface [polypeptide binding]; other site 1091494005345 interdomain contacts; other site 1091494005346 partial ornithine binding site; other site 1091494005347 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1091494005348 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1091494005349 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1091494005350 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1091494005351 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1091494005352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005353 S-adenosylmethionine binding site [chemical binding]; other site 1091494005354 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1091494005355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494005356 Walker A motif; other site 1091494005357 ATP binding site [chemical binding]; other site 1091494005358 Walker B motif; other site 1091494005359 arginine finger; other site 1091494005360 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091494005361 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1091494005362 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1091494005363 active site 1091494005364 substrate binding site [chemical binding]; other site 1091494005365 metal binding site [ion binding]; metal-binding site 1091494005366 triosephosphate isomerase; Provisional; Region: PRK14567 1091494005367 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1091494005368 substrate binding site [chemical binding]; other site 1091494005369 dimer interface [polypeptide binding]; other site 1091494005370 catalytic triad [active] 1091494005371 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1091494005372 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 1091494005373 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1091494005374 EthD domain; Region: EthD; cl17553 1091494005375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091494005376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494005377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1091494005378 dimerization interface [polypeptide binding]; other site 1091494005379 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1091494005380 active site 1091494005381 catalytic residues [active] 1091494005382 metal binding site [ion binding]; metal-binding site 1091494005383 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1091494005384 Transglycosylase; Region: Transgly; cl17702 1091494005385 Cytochrome c; Region: Cytochrom_C; cl11414 1091494005386 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1091494005387 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1091494005388 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1091494005389 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1091494005390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005391 S-adenosylmethionine binding site [chemical binding]; other site 1091494005392 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1091494005393 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1091494005394 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494005395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005396 active site 1091494005397 phosphorylation site [posttranslational modification] 1091494005398 intermolecular recognition site; other site 1091494005399 dimerization interface [polypeptide binding]; other site 1091494005400 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494005401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005402 active site 1091494005403 phosphorylation site [posttranslational modification] 1091494005404 intermolecular recognition site; other site 1091494005405 dimerization interface [polypeptide binding]; other site 1091494005406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005407 PAS fold; Region: PAS_3; pfam08447 1091494005408 putative active site [active] 1091494005409 heme pocket [chemical binding]; other site 1091494005410 PAS domain S-box; Region: sensory_box; TIGR00229 1091494005411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005412 PAS domain; Region: PAS_9; pfam13426 1091494005413 putative active site [active] 1091494005414 heme pocket [chemical binding]; other site 1091494005415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494005416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494005417 metal binding site [ion binding]; metal-binding site 1091494005418 active site 1091494005419 I-site; other site 1091494005420 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 1091494005421 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1091494005422 aromatic arch; other site 1091494005423 DCoH dimer interaction site [polypeptide binding]; other site 1091494005424 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1091494005425 DCoH tetramer interaction site [polypeptide binding]; other site 1091494005426 substrate binding site [chemical binding]; other site 1091494005427 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1091494005428 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1091494005429 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1091494005430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1091494005431 hypothetical protein; Validated; Region: PRK00029 1091494005432 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1091494005433 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1091494005434 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1091494005435 YciI-like protein; Reviewed; Region: PRK11370 1091494005436 intracellular septation protein A; Reviewed; Region: PRK00259 1091494005437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1091494005438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494005440 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1091494005441 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1091494005442 putative catalytic cysteine [active] 1091494005443 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1091494005444 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1091494005445 active site 1091494005446 (T/H)XGH motif; other site 1091494005447 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1091494005448 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1091494005449 putative deacylase active site [active] 1091494005450 peptide chain release factor 1; Provisional; Region: PRK04011 1091494005451 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1091494005452 putative active site [active] 1091494005453 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1091494005454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494005455 dimerization interface [polypeptide binding]; other site 1091494005456 putative DNA binding site [nucleotide binding]; other site 1091494005457 putative Zn2+ binding site [ion binding]; other site 1091494005458 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1091494005459 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1091494005460 active site 1091494005461 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1091494005462 Sodium Bile acid symporter family; Region: SBF; cl17470 1091494005463 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1091494005464 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1091494005465 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091494005466 P loop; other site 1091494005467 Nucleotide binding site [chemical binding]; other site 1091494005468 DTAP/Switch II; other site 1091494005469 Switch I; other site 1091494005470 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091494005471 P loop; other site 1091494005472 Nucleotide binding site [chemical binding]; other site 1091494005473 DTAP/Switch II; other site 1091494005474 Switch I; other site 1091494005475 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091494005476 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091494005477 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1091494005478 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494005479 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494005480 protein binding site [polypeptide binding]; other site 1091494005481 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1091494005482 active site 1091494005483 PBP superfamily domain; Region: PBP_like_2; cl17296 1091494005484 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1091494005485 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1091494005486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494005487 dimer interface [polypeptide binding]; other site 1091494005488 conserved gate region; other site 1091494005489 putative PBP binding loops; other site 1091494005490 ABC-ATPase subunit interface; other site 1091494005491 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1091494005492 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1091494005493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494005494 dimer interface [polypeptide binding]; other site 1091494005495 conserved gate region; other site 1091494005496 putative PBP binding loops; other site 1091494005497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1091494005498 ABC-ATPase subunit interface; other site 1091494005499 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1091494005500 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1091494005501 Walker A/P-loop; other site 1091494005502 ATP binding site [chemical binding]; other site 1091494005503 Q-loop/lid; other site 1091494005504 ABC transporter signature motif; other site 1091494005505 Walker B; other site 1091494005506 D-loop; other site 1091494005507 H-loop/switch region; other site 1091494005508 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1091494005509 PhoU domain; Region: PhoU; pfam01895 1091494005510 PhoU domain; Region: PhoU; pfam01895 1091494005511 Predicted GTPase [General function prediction only]; Region: COG2403 1091494005512 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 1091494005513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494005514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005515 S-adenosylmethionine binding site [chemical binding]; other site 1091494005516 MarR family; Region: MarR_2; cl17246 1091494005517 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091494005518 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1091494005519 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1091494005520 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1091494005521 putative active site; other site 1091494005522 catalytic triad [active] 1091494005523 putative dimer interface [polypeptide binding]; other site 1091494005524 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1091494005525 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1091494005526 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1091494005527 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1091494005528 Walker A/P-loop; other site 1091494005529 ATP binding site [chemical binding]; other site 1091494005530 Q-loop/lid; other site 1091494005531 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1091494005532 ABC transporter signature motif; other site 1091494005533 Walker B; other site 1091494005534 D-loop; other site 1091494005535 H-loop/switch region; other site 1091494005536 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1091494005537 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1091494005538 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1091494005539 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1091494005540 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1091494005541 GrpE; Region: GrpE; pfam01025 1091494005542 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1091494005543 dimer interface [polypeptide binding]; other site 1091494005544 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1091494005545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1091494005546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091494005547 nucleotide binding site [chemical binding]; other site 1091494005548 chaperone protein DnaJ; Provisional; Region: PRK10767 1091494005549 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494005550 HSP70 interaction site [polypeptide binding]; other site 1091494005551 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1091494005552 substrate binding site [polypeptide binding]; other site 1091494005553 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1091494005554 Zn binding sites [ion binding]; other site 1091494005555 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091494005556 dimer interface [polypeptide binding]; other site 1091494005557 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1091494005558 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1091494005559 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1091494005560 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1091494005561 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091494005562 catalytic loop [active] 1091494005563 iron binding site [ion binding]; other site 1091494005564 4Fe-4S binding domain; Region: Fer4; pfam00037 1091494005565 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1091494005566 [4Fe-4S] binding site [ion binding]; other site 1091494005567 molybdopterin cofactor binding site; other site 1091494005568 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1091494005569 molybdopterin cofactor binding site; other site 1091494005570 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1091494005571 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 1091494005572 putative dimer interface [polypeptide binding]; other site 1091494005573 [2Fe-2S] cluster binding site [ion binding]; other site 1091494005574 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1091494005575 SLBB domain; Region: SLBB; pfam10531 1091494005576 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1091494005577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091494005578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494005579 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1091494005580 putative dimerization interface [polypeptide binding]; other site 1091494005581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091494005582 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1091494005583 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1091494005584 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494005585 putative active site [active] 1091494005586 Domain of unknown function DUF302; Region: DUF302; cl01364 1091494005587 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1091494005588 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1091494005589 GTP binding site; other site 1091494005590 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1091494005591 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 1091494005592 heat shock protein HtpX; Provisional; Region: PRK05457 1091494005593 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1091494005594 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1091494005595 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1091494005596 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1091494005597 dimer interface [polypeptide binding]; other site 1091494005598 ADP-ribose binding site [chemical binding]; other site 1091494005599 active site 1091494005600 nudix motif; other site 1091494005601 metal binding site [ion binding]; metal-binding site 1091494005602 Predicted membrane protein [Function unknown]; Region: COG3671 1091494005603 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1091494005604 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091494005605 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1091494005606 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091494005607 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1091494005608 putative NAD(P) binding site [chemical binding]; other site 1091494005609 active site 1091494005610 putative substrate binding site [chemical binding]; other site 1091494005611 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1091494005612 four helix bundle protein; Region: TIGR02436 1091494005613 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1091494005614 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1091494005615 putative ADP-binding pocket [chemical binding]; other site 1091494005616 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1091494005617 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1091494005618 active site 1091494005619 dimer interface [polypeptide binding]; other site 1091494005620 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1091494005621 Ligand Binding Site [chemical binding]; other site 1091494005622 Molecular Tunnel; other site 1091494005623 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 1091494005624 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1091494005625 PilZ domain; Region: PilZ; pfam07238 1091494005626 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1091494005627 MASE1; Region: MASE1; cl17823 1091494005628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494005629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494005630 dimer interface [polypeptide binding]; other site 1091494005631 phosphorylation site [posttranslational modification] 1091494005632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494005633 ATP binding site [chemical binding]; other site 1091494005634 Mg2+ binding site [ion binding]; other site 1091494005635 G-X-G motif; other site 1091494005636 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494005637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005638 active site 1091494005639 phosphorylation site [posttranslational modification] 1091494005640 intermolecular recognition site; other site 1091494005641 dimerization interface [polypeptide binding]; other site 1091494005642 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1091494005643 Cytochrome c; Region: Cytochrom_C; pfam00034 1091494005644 MASE1; Region: MASE1; pfam05231 1091494005645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005646 PAS domain; Region: PAS_9; pfam13426 1091494005647 putative active site [active] 1091494005648 heme pocket [chemical binding]; other site 1091494005649 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494005650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494005651 metal binding site [ion binding]; metal-binding site 1091494005652 active site 1091494005653 I-site; other site 1091494005654 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494005655 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1091494005656 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1091494005657 dimer interface [polypeptide binding]; other site 1091494005658 motif 1; other site 1091494005659 active site 1091494005660 motif 2; other site 1091494005661 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1091494005662 putative deacylase active site [active] 1091494005663 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091494005664 active site 1091494005665 motif 3; other site 1091494005666 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1091494005667 anticodon binding site; other site 1091494005668 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1091494005669 active site 1091494005670 dimer interface [polypeptide binding]; other site 1091494005671 magnesium binding site [ion binding]; other site 1091494005672 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1091494005673 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1091494005674 tetramer interface [polypeptide binding]; other site 1091494005675 active site 1091494005676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494005677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091494005678 putative substrate translocation pore; other site 1091494005679 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1091494005680 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1091494005681 dimer interface [polypeptide binding]; other site 1091494005682 ssDNA binding site [nucleotide binding]; other site 1091494005683 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091494005684 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494005685 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1091494005686 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 1091494005687 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1091494005688 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494005689 ligand binding site [chemical binding]; other site 1091494005690 PilZ domain; Region: PilZ; pfam07238 1091494005691 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1091494005692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494005693 putative DNA binding site [nucleotide binding]; other site 1091494005694 putative Zn2+ binding site [ion binding]; other site 1091494005695 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1091494005696 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1091494005697 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091494005698 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1091494005699 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494005700 Sporulation related domain; Region: SPOR; pfam05036 1091494005701 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1091494005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1091494005703 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494005704 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1091494005705 phosphopeptide binding site; other site 1091494005706 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1091494005707 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1091494005708 hypothetical protein; Provisional; Region: PRK07033 1091494005709 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1091494005710 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494005711 ligand binding site [chemical binding]; other site 1091494005712 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1091494005713 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1091494005714 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1091494005715 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1091494005716 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091494005717 active site 1091494005718 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1091494005719 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1091494005720 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1091494005721 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1091494005722 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1091494005723 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1091494005724 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1091494005725 ImpE protein; Region: ImpE; pfam07024 1091494005726 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1091494005727 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1091494005728 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1091494005729 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1091494005730 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1091494005731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494005732 Walker A motif; other site 1091494005733 ATP binding site [chemical binding]; other site 1091494005734 Walker B motif; other site 1091494005735 arginine finger; other site 1091494005736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494005737 Walker A motif; other site 1091494005738 ATP binding site [chemical binding]; other site 1091494005739 Walker B motif; other site 1091494005740 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1091494005741 Papain-like cysteine protease AvrRpt2; Region: Peptidase_C70; pfam12385 1091494005742 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1091494005743 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1091494005744 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1091494005745 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1091494005746 PAAR motif; Region: PAAR_motif; pfam05488 1091494005747 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1091494005748 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1091494005749 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1091494005750 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1091494005751 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1091494005752 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 1091494005753 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1091494005754 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1091494005755 active site 1091494005756 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1091494005757 Transposase; Region: HTH_Tnp_1; cl17663 1091494005758 putative transposase OrfB; Reviewed; Region: PHA02517 1091494005759 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494005760 Integrase core domain; Region: rve; pfam00665 1091494005761 Integrase core domain; Region: rve_3; pfam13683 1091494005762 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494005763 putative active site [active] 1091494005764 conserved hypothetical protein; Region: TIGR02270 1091494005765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494005766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494005767 active site 1091494005768 ATP binding site [chemical binding]; other site 1091494005769 substrate binding site [chemical binding]; other site 1091494005770 activation loop (A-loop); other site 1091494005771 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494005772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494005773 active site 1091494005774 ATP binding site [chemical binding]; other site 1091494005775 substrate binding site [chemical binding]; other site 1091494005776 activation loop (A-loop); other site 1091494005777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494005778 binding surface 1091494005779 TPR motif; other site 1091494005780 PAS domain; Region: PAS_9; pfam13426 1091494005781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005782 PAS domain; Region: PAS_9; pfam13426 1091494005783 putative active site [active] 1091494005784 heme pocket [chemical binding]; other site 1091494005785 PAS domain S-box; Region: sensory_box; TIGR00229 1091494005786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005787 putative active site [active] 1091494005788 heme pocket [chemical binding]; other site 1091494005789 PAS domain S-box; Region: sensory_box; TIGR00229 1091494005790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005791 putative active site [active] 1091494005792 heme pocket [chemical binding]; other site 1091494005793 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1091494005794 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1091494005795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091494005796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494005797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494005798 Rubredoxin [Energy production and conversion]; Region: COG1773 1091494005799 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1091494005800 iron binding site [ion binding]; other site 1091494005801 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1091494005802 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1091494005803 HupF/HypC family; Region: HupF_HypC; pfam01455 1091494005804 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1091494005805 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1091494005806 dimerization interface [polypeptide binding]; other site 1091494005807 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1091494005808 ATP binding site [chemical binding]; other site 1091494005809 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091494005810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494005811 active site 1091494005812 phosphorylation site [posttranslational modification] 1091494005813 intermolecular recognition site; other site 1091494005814 dimerization interface [polypeptide binding]; other site 1091494005815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494005816 DNA binding site [nucleotide binding] 1091494005817 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494005818 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494005819 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494005820 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1091494005821 Ligand Binding Site [chemical binding]; other site 1091494005822 Acylphosphatase; Region: Acylphosphatase; pfam00708 1091494005823 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1091494005824 HypF finger; Region: zf-HYPF; pfam07503 1091494005825 HypF finger; Region: zf-HYPF; pfam07503 1091494005826 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1091494005827 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1091494005828 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1091494005829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091494005830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091494005831 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1091494005832 dimer interface [polypeptide binding]; other site 1091494005833 active site 1091494005834 metal binding site [ion binding]; metal-binding site 1091494005835 glutathione binding site [chemical binding]; other site 1091494005836 conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096 1091494005837 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091494005838 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091494005839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494005840 catalytic residue [active] 1091494005841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091494005842 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1091494005843 active site 1091494005844 metal binding site [ion binding]; metal-binding site 1091494005845 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1091494005846 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1091494005847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494005848 ATP binding site [chemical binding]; other site 1091494005849 putative Mg++ binding site [ion binding]; other site 1091494005850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494005851 nucleotide binding region [chemical binding]; other site 1091494005852 ATP-binding site [chemical binding]; other site 1091494005853 Helicase associated domain (HA2); Region: HA2; pfam04408 1091494005854 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1091494005855 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1091494005856 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1091494005857 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1091494005858 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1091494005859 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1091494005860 HopJ type III effector protein; Region: HopJ; pfam08888 1091494005861 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1091494005862 SmpB-tmRNA interface; other site 1091494005863 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1091494005864 Na2 binding site [ion binding]; other site 1091494005865 putative substrate binding site 1 [chemical binding]; other site 1091494005866 Na binding site 1 [ion binding]; other site 1091494005867 putative substrate binding site 2 [chemical binding]; other site 1091494005868 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1091494005869 putative coenzyme Q binding site [chemical binding]; other site 1091494005870 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1091494005871 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1091494005872 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1091494005873 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1091494005874 metal binding site 2 [ion binding]; metal-binding site 1091494005875 putative DNA binding helix; other site 1091494005876 metal binding site 1 [ion binding]; metal-binding site 1091494005877 dimer interface [polypeptide binding]; other site 1091494005878 structural Zn2+ binding site [ion binding]; other site 1091494005879 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1091494005880 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494005881 FtsX-like permease family; Region: FtsX; pfam02687 1091494005882 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1091494005883 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494005884 Walker A/P-loop; other site 1091494005885 ATP binding site [chemical binding]; other site 1091494005886 Q-loop/lid; other site 1091494005887 ABC transporter signature motif; other site 1091494005888 Walker B; other site 1091494005889 D-loop; other site 1091494005890 H-loop/switch region; other site 1091494005891 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1091494005892 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1091494005893 ComEC family competence protein; Provisional; Region: PRK11539 1091494005894 Competence protein; Region: Competence; pfam03772 1091494005895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1091494005896 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1091494005897 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494005898 putative Zn2+ binding site [ion binding]; other site 1091494005899 putative DNA binding site [nucleotide binding]; other site 1091494005900 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1091494005901 putative ABC transporter; Region: ycf24; CHL00085 1091494005902 YcfA-like protein; Region: YcfA; cl00752 1091494005903 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1091494005904 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1091494005905 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1091494005906 Walker A/P-loop; other site 1091494005907 ATP binding site [chemical binding]; other site 1091494005908 Q-loop/lid; other site 1091494005909 ABC transporter signature motif; other site 1091494005910 Walker B; other site 1091494005911 D-loop; other site 1091494005912 H-loop/switch region; other site 1091494005913 FeS assembly protein SufD; Region: sufD; TIGR01981 1091494005914 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1091494005915 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494005916 putative active site [active] 1091494005917 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1091494005918 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1091494005919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494005920 catalytic residue [active] 1091494005921 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1091494005922 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1091494005923 trimerization site [polypeptide binding]; other site 1091494005924 active site 1091494005925 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1091494005926 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1091494005927 [2Fe-2S] cluster binding site [ion binding]; other site 1091494005928 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1091494005929 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1091494005930 RF-1 domain; Region: RF-1; pfam00472 1091494005931 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1091494005932 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1091494005933 dimer interface [polypeptide binding]; other site 1091494005934 putative anticodon binding site; other site 1091494005935 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1091494005936 motif 1; other site 1091494005937 active site 1091494005938 motif 2; other site 1091494005939 motif 3; other site 1091494005940 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494005941 putative active site [active] 1091494005942 VanZ like family; Region: VanZ; pfam04892 1091494005943 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1091494005944 PAS domain S-box; Region: sensory_box; TIGR00229 1091494005945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494005946 putative active site [active] 1091494005947 heme pocket [chemical binding]; other site 1091494005948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494005949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494005950 metal binding site [ion binding]; metal-binding site 1091494005951 active site 1091494005952 I-site; other site 1091494005953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494005954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1091494005955 hypothetical protein; Provisional; Region: PRK08317 1091494005956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494005957 S-adenosylmethionine binding site [chemical binding]; other site 1091494005958 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1091494005959 active site 1091494005960 PilZ domain; Region: PilZ; cl01260 1091494005961 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1091494005962 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1091494005963 thymidylate kinase; Validated; Region: tmk; PRK00698 1091494005964 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1091494005965 TMP-binding site; other site 1091494005966 ATP-binding site [chemical binding]; other site 1091494005967 YceG-like family; Region: YceG; pfam02618 1091494005968 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1091494005969 dimerization interface [polypeptide binding]; other site 1091494005970 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1091494005971 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1091494005972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494005973 catalytic residue [active] 1091494005974 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1091494005975 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091494005976 dimer interface [polypeptide binding]; other site 1091494005977 active site 1091494005978 acyl carrier protein; Provisional; Region: acpP; PRK00982 1091494005979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1091494005980 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1091494005981 NAD(P) binding site [chemical binding]; other site 1091494005982 homotetramer interface [polypeptide binding]; other site 1091494005983 homodimer interface [polypeptide binding]; other site 1091494005984 active site 1091494005985 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1091494005986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1091494005987 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1091494005988 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1091494005989 dimer interface [polypeptide binding]; other site 1091494005990 active site 1091494005991 CoA binding pocket [chemical binding]; other site 1091494005992 putative phosphate acyltransferase; Provisional; Region: PRK05331 1091494005993 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1091494005994 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1091494005995 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1091494005996 active site 1091494005997 dimer interface [polypeptide binding]; other site 1091494005998 HDOD domain; Region: HDOD; pfam08668 1091494005999 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1091494006000 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1091494006001 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494006002 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494006003 catalytic residue [active] 1091494006004 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 1091494006005 Walker A/P-loop; other site 1091494006006 ATP binding site [chemical binding]; other site 1091494006007 Q-loop/lid; other site 1091494006008 ABC transporter signature motif; other site 1091494006009 Walker B; other site 1091494006010 D-loop; other site 1091494006011 H-loop/switch region; other site 1091494006012 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1091494006013 GTP cyclohydrolase I; Provisional; Region: PLN03044 1091494006014 homodecamer interface [polypeptide binding]; other site 1091494006015 active site 1091494006016 putative catalytic site residues [active] 1091494006017 zinc binding site [ion binding]; other site 1091494006018 GTP-CH-I/GFRP interaction surface; other site 1091494006019 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1091494006020 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1091494006021 FMN binding site [chemical binding]; other site 1091494006022 active site 1091494006023 catalytic residues [active] 1091494006024 substrate binding site [chemical binding]; other site 1091494006025 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1091494006026 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1091494006027 trimer interface [polypeptide binding]; other site 1091494006028 putative metal binding site [ion binding]; other site 1091494006029 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1091494006030 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1091494006031 Short C-terminal domain; Region: SHOCT; pfam09851 1091494006032 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1091494006033 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1091494006034 AAA domain; Region: AAA_22; pfam13401 1091494006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006036 Walker A motif; other site 1091494006037 ATP binding site [chemical binding]; other site 1091494006038 Walker B motif; other site 1091494006039 arginine finger; other site 1091494006040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494006041 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494006042 ligand binding site [chemical binding]; other site 1091494006043 HDOD domain; Region: HDOD; pfam08668 1091494006044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494006045 ligand binding site [chemical binding]; other site 1091494006046 HDOD domain; Region: HDOD; pfam08668 1091494006047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1091494006048 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1091494006049 HDOD domain; Region: HDOD; pfam08668 1091494006050 oligopeptidase A; Provisional; Region: PRK10911 1091494006051 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1091494006052 active site 1091494006053 Zn binding site [ion binding]; other site 1091494006054 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1091494006055 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1091494006056 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1091494006057 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1091494006058 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1091494006059 putative CheA interaction surface; other site 1091494006060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494006061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494006062 dimer interface [polypeptide binding]; other site 1091494006063 putative CheW interface [polypeptide binding]; other site 1091494006064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494006065 HAMP domain; Region: HAMP; pfam00672 1091494006066 Histidine kinase; Region: HisKA_3; pfam07730 1091494006067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494006068 ATP binding site [chemical binding]; other site 1091494006069 Mg2+ binding site [ion binding]; other site 1091494006070 G-X-G motif; other site 1091494006071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494006072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494006073 active site 1091494006074 phosphorylation site [posttranslational modification] 1091494006075 intermolecular recognition site; other site 1091494006076 dimerization interface [polypeptide binding]; other site 1091494006077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494006078 DNA binding residues [nucleotide binding] 1091494006079 dimerization interface [polypeptide binding]; other site 1091494006080 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1091494006081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006082 Walker A motif; other site 1091494006083 ATP binding site [chemical binding]; other site 1091494006084 Walker B motif; other site 1091494006085 arginine finger; other site 1091494006086 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091494006087 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 1091494006088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme 1091494006089 Protein of unknown function DUF45; Region: DUF45; pfam01863 1091494006090 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1091494006091 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1091494006092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494006093 ATP binding site [chemical binding]; other site 1091494006094 putative Mg++ binding site [ion binding]; other site 1091494006095 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1091494006096 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1091494006097 Fic family protein [Function unknown]; Region: COG3177 1091494006098 Fic/DOC family; Region: Fic; pfam02661 1091494006099 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494006100 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494006101 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1091494006102 putative active site [active] 1091494006103 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1091494006104 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1091494006105 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1091494006106 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1091494006107 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494006108 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494006109 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1091494006110 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1091494006111 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091494006112 oligomeric interface; other site 1091494006113 putative active site [active] 1091494006114 homodimer interface [polypeptide binding]; other site 1091494006115 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494006116 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1091494006117 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1091494006118 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1091494006119 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1091494006120 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1091494006121 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1091494006122 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1091494006123 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1091494006124 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1091494006125 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 1091494006126 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1091494006127 nudix motif; other site 1091494006128 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1091494006129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494006130 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494006131 LabA_like proteins; Region: LabA_like; cd06167 1091494006132 putative metal binding site [ion binding]; other site 1091494006133 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1091494006134 RES domain; Region: RES; cl02411 1091494006135 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1091494006136 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1091494006137 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494006138 metal ion-dependent adhesion site (MIDAS); other site 1091494006139 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494006140 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091494006141 phosphopeptide binding site; other site 1091494006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1091494006143 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1091494006144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494006145 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494006146 phosphopeptide binding site; other site 1091494006147 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1091494006148 active site 1091494006149 Protein kinase domain; Region: Pkinase; pfam00069 1091494006150 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494006151 active site 1091494006152 ATP binding site [chemical binding]; other site 1091494006153 substrate binding site [chemical binding]; other site 1091494006154 activation loop (A-loop); other site 1091494006155 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1091494006156 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1091494006157 Protein kinase domain; Region: Pkinase; pfam00069 1091494006158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494006159 active site 1091494006160 ATP binding site [chemical binding]; other site 1091494006161 substrate binding site [chemical binding]; other site 1091494006162 activation loop (A-loop); other site 1091494006163 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1091494006164 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1091494006165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494006166 Protein kinase domain; Region: Pkinase; pfam00069 1091494006167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494006168 active site 1091494006169 ATP binding site [chemical binding]; other site 1091494006170 substrate binding site [chemical binding]; other site 1091494006171 activation loop (A-loop); other site 1091494006172 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494006173 phosphopeptide binding site; other site 1091494006174 PIN domain; Region: PIN_3; pfam13470 1091494006175 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1091494006176 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 1091494006177 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494006178 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494006179 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1091494006180 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1091494006181 Transposase; Region: HTH_Tnp_1; cl17663 1091494006182 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494006183 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494006184 Integrase core domain; Region: rve; pfam00665 1091494006185 Integrase core domain; Region: rve_3; pfam13683 1091494006186 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1091494006187 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1091494006188 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1091494006189 Presynaptic Site I dimer interface [polypeptide binding]; other site 1091494006190 catalytic residues [active] 1091494006191 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1091494006192 Synaptic Flat tetramer interface [polypeptide binding]; other site 1091494006193 Synaptic Site I dimer interface [polypeptide binding]; other site 1091494006194 DNA binding site [nucleotide binding] 1091494006195 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1091494006196 DNA-binding interface [nucleotide binding]; DNA binding site 1091494006197 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1091494006198 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1091494006199 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1091494006200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494006201 active site 1091494006202 DNA binding site [nucleotide binding] 1091494006203 Int/Topo IB signature motif; other site 1091494006204 GTP-binding protein YchF; Reviewed; Region: PRK09601 1091494006205 YchF GTPase; Region: YchF; cd01900 1091494006206 G1 box; other site 1091494006207 GTP/Mg2+ binding site [chemical binding]; other site 1091494006208 Switch I region; other site 1091494006209 G2 box; other site 1091494006210 Switch II region; other site 1091494006211 G3 box; other site 1091494006212 G4 box; other site 1091494006213 G5 box; other site 1091494006214 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1091494006215 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1091494006216 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1091494006217 HDOD domain; Region: HDOD; pfam08668 1091494006218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494006219 Zn2+ binding site [ion binding]; other site 1091494006220 Mg2+ binding site [ion binding]; other site 1091494006221 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1091494006222 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1091494006223 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091494006224 nucleoside/Zn binding site; other site 1091494006225 dimer interface [polypeptide binding]; other site 1091494006226 catalytic motif [active] 1091494006227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494006228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494006229 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494006230 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494006231 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494006232 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1091494006233 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1091494006234 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1091494006235 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1091494006236 Fic/DOC family; Region: Fic; pfam02661 1091494006237 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1091494006238 putative active site [active] 1091494006239 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1091494006240 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1091494006241 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1091494006242 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 1091494006243 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1091494006244 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1091494006245 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1091494006246 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1091494006247 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1091494006248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091494006249 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1091494006250 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1091494006251 putative active site [active] 1091494006252 putative NTP binding site [chemical binding]; other site 1091494006253 putative nucleic acid binding site [nucleotide binding]; other site 1091494006254 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1091494006255 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 1091494006256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006257 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1091494006258 Walker B motif; other site 1091494006259 arginine finger; other site 1091494006260 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1091494006261 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1091494006262 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1091494006263 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1091494006264 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1091494006265 PAAR motif; Region: PAAR_motif; pfam05488 1091494006266 Phage protein D [General function prediction only]; Region: COG3500 1091494006267 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1091494006268 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1091494006269 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1091494006270 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1091494006271 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1091494006272 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1091494006273 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1091494006274 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1091494006275 SpoVR family protein; Provisional; Region: PRK11767 1091494006276 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1091494006277 hypothetical protein; Provisional; Region: PRK05325 1091494006278 PrkA family serine protein kinase; Provisional; Region: PRK15455 1091494006279 AAA ATPase domain; Region: AAA_16; pfam13191 1091494006280 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1091494006281 Pirin-related protein [General function prediction only]; Region: COG1741 1091494006282 Pirin; Region: Pirin; pfam02678 1091494006283 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1091494006284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1091494006285 putative effector binding pocket; other site 1091494006286 putative dimerization interface [polypeptide binding]; other site 1091494006287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494006288 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494006289 intermolecular recognition site; other site 1091494006290 active site 1091494006291 dimerization interface [polypeptide binding]; other site 1091494006292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006293 Walker A motif; other site 1091494006294 ATP binding site [chemical binding]; other site 1091494006295 Walker B motif; other site 1091494006296 arginine finger; other site 1091494006297 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494006298 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1091494006299 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494006300 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494006301 catalytic residue [active] 1091494006302 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494006303 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494006304 ligand binding site [chemical binding]; other site 1091494006305 flexible hinge region; other site 1091494006306 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1091494006307 SEC-C motif; Region: SEC-C; pfam02810 1091494006308 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1091494006309 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1091494006310 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1091494006311 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1091494006312 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1091494006313 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1091494006314 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1091494006315 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1091494006316 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1091494006317 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1091494006318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091494006319 catalytic loop [active] 1091494006320 iron binding site [ion binding]; other site 1091494006321 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1091494006322 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1091494006323 Ligand binding site; other site 1091494006324 metal-binding site 1091494006325 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1091494006326 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1091494006327 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1091494006328 metal binding site 2 [ion binding]; metal-binding site 1091494006329 putative DNA binding helix; other site 1091494006330 metal binding site 1 [ion binding]; metal-binding site 1091494006331 dimer interface [polypeptide binding]; other site 1091494006332 structural Zn2+ binding site [ion binding]; other site 1091494006333 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1091494006334 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1091494006335 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1091494006336 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1091494006337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091494006338 putative acyl-acceptor binding pocket; other site 1091494006339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1091494006340 PAS domain S-box; Region: sensory_box; TIGR00229 1091494006341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006342 putative active site [active] 1091494006343 heme pocket [chemical binding]; other site 1091494006344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006345 PAS domain; Region: PAS_9; pfam13426 1091494006346 putative active site [active] 1091494006347 heme pocket [chemical binding]; other site 1091494006348 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494006349 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494006350 metal binding site [ion binding]; metal-binding site 1091494006351 active site 1091494006352 I-site; other site 1091494006353 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1091494006354 Na binding site [ion binding]; other site 1091494006355 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 1091494006356 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1091494006357 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1091494006358 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1091494006359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494006360 ATP binding site [chemical binding]; other site 1091494006361 Mg2+ binding site [ion binding]; other site 1091494006362 G-X-G motif; other site 1091494006363 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091494006364 anti sigma factor interaction site; other site 1091494006365 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494006366 regulatory phosphorylation site [posttranslational modification]; other site 1091494006367 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1091494006368 Chromate transporter; Region: Chromate_transp; pfam02417 1091494006369 NlpC/P60 family; Region: NLPC_P60; pfam00877 1091494006370 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1091494006371 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1091494006372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494006373 ATP binding site [chemical binding]; other site 1091494006374 putative Mg++ binding site [ion binding]; other site 1091494006375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494006376 nucleotide binding region [chemical binding]; other site 1091494006377 ATP-binding site [chemical binding]; other site 1091494006378 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1091494006379 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1091494006380 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1091494006381 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1091494006382 catalytic site [active] 1091494006383 active site 1091494006384 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1091494006385 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1091494006386 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091494006387 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091494006388 active site 1091494006389 catalytic site [active] 1091494006390 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1091494006391 Predicted membrane protein [Function unknown]; Region: COG3174 1091494006392 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1091494006393 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1091494006394 dimer interface [polypeptide binding]; other site 1091494006395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1091494006396 metal binding site [ion binding]; metal-binding site 1091494006397 exonuclease I; Provisional; Region: sbcB; PRK11779 1091494006398 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1091494006399 active site 1091494006400 catalytic site [active] 1091494006401 substrate binding site [chemical binding]; other site 1091494006402 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1091494006403 FOG: CBS domain [General function prediction only]; Region: COG0517 1091494006404 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1091494006405 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1091494006406 ApbE family; Region: ApbE; pfam02424 1091494006407 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1091494006408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1091494006409 catalytic loop [active] 1091494006410 iron binding site [ion binding]; other site 1091494006411 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1091494006412 FAD binding pocket [chemical binding]; other site 1091494006413 FAD binding motif [chemical binding]; other site 1091494006414 phosphate binding motif [ion binding]; other site 1091494006415 beta-alpha-beta structure motif; other site 1091494006416 NAD binding pocket [chemical binding]; other site 1091494006417 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1091494006418 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1091494006419 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1091494006420 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1091494006421 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1091494006422 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1091494006423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091494006424 E3 interaction surface; other site 1091494006425 lipoyl attachment site [posttranslational modification]; other site 1091494006426 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1091494006427 quinolinate synthetase; Provisional; Region: PRK09375 1091494006428 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1091494006429 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1091494006430 dimer interface [polypeptide binding]; other site 1091494006431 anticodon binding site; other site 1091494006432 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1091494006433 homodimer interface [polypeptide binding]; other site 1091494006434 motif 1; other site 1091494006435 active site 1091494006436 motif 2; other site 1091494006437 GAD domain; Region: GAD; pfam02938 1091494006438 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091494006439 active site 1091494006440 motif 3; other site 1091494006441 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1091494006442 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1091494006443 active site 1091494006444 substrate binding pocket [chemical binding]; other site 1091494006445 dimer interface [polypeptide binding]; other site 1091494006446 Protein of unknown function (DUF502); Region: DUF502; cl01107 1091494006447 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1091494006448 nucleotide binding site [chemical binding]; other site 1091494006449 substrate binding site [chemical binding]; other site 1091494006450 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1091494006451 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1091494006452 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1091494006453 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1091494006454 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1091494006455 dimerization interface 3.5A [polypeptide binding]; other site 1091494006456 active site 1091494006457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1091494006458 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494006459 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1091494006460 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1091494006461 TRAM domain; Region: TRAM; cl01282 1091494006462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006463 S-adenosylmethionine binding site [chemical binding]; other site 1091494006464 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 1091494006465 cysteine synthase B; Region: cysM; TIGR01138 1091494006466 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091494006467 dimer interface [polypeptide binding]; other site 1091494006468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494006469 catalytic residue [active] 1091494006470 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1091494006471 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494006472 GAF domain; Region: GAF_3; pfam13492 1091494006473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494006474 dimer interface [polypeptide binding]; other site 1091494006475 phosphorylation site [posttranslational modification] 1091494006476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494006477 ATP binding site [chemical binding]; other site 1091494006478 Mg2+ binding site [ion binding]; other site 1091494006479 G-X-G motif; other site 1091494006480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494006481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494006482 active site 1091494006483 phosphorylation site [posttranslational modification] 1091494006484 intermolecular recognition site; other site 1091494006485 dimerization interface [polypeptide binding]; other site 1091494006486 PAS domain S-box; Region: sensory_box; TIGR00229 1091494006487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006488 putative active site [active] 1091494006489 heme pocket [chemical binding]; other site 1091494006490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006491 PAS domain; Region: PAS_9; pfam13426 1091494006492 putative active site [active] 1091494006493 heme pocket [chemical binding]; other site 1091494006494 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494006495 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494006496 metal binding site [ion binding]; metal-binding site 1091494006497 active site 1091494006498 I-site; other site 1091494006499 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494006500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494006501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494006502 metal binding site [ion binding]; metal-binding site 1091494006503 active site 1091494006504 I-site; other site 1091494006505 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 1091494006506 Haem-binding domain; Region: Haem_bd; pfam14376 1091494006507 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1091494006508 cytochrome c-550; Provisional; Region: psbV; cl17239 1091494006509 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1091494006510 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1091494006511 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1091494006512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091494006513 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091494006514 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1091494006515 Walker A/P-loop; other site 1091494006516 ATP binding site [chemical binding]; other site 1091494006517 Q-loop/lid; other site 1091494006518 ABC transporter signature motif; other site 1091494006519 Walker B; other site 1091494006520 D-loop; other site 1091494006521 H-loop/switch region; other site 1091494006522 Evidence 4 : Homologs of previously reported genes of unknown function 1091494006523 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1091494006524 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1091494006525 Evidence 7 : Gene remnant; Product type e : enzyme 1091494006526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1091494006527 DNA binding residues [nucleotide binding] 1091494006528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091494006529 Integrase core domain; Region: rve; pfam00665 1091494006530 transposase; Provisional; Region: PRK06526 1091494006531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006532 Walker A motif; other site 1091494006533 ATP binding site [chemical binding]; other site 1091494006534 Walker B motif; other site 1091494006535 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1091494006536 active site 1091494006537 catalytic residues [active] 1091494006538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494006539 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494006540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494006541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091494006542 short chain dehydrogenase; Provisional; Region: PRK06198 1091494006543 NAD(P) binding site [chemical binding]; other site 1091494006544 active site 1091494006545 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494006546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006547 S-adenosylmethionine binding site [chemical binding]; other site 1091494006548 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 1091494006549 diiron binding motif [ion binding]; other site 1091494006550 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1091494006551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494006552 Walker A/P-loop; other site 1091494006553 ATP binding site [chemical binding]; other site 1091494006554 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1091494006555 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494006556 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1091494006557 FeoA domain; Region: FeoA; pfam04023 1091494006558 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1091494006559 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1091494006560 G1 box; other site 1091494006561 G1 box; other site 1091494006562 GTP/Mg2+ binding site [chemical binding]; other site 1091494006563 GTP/Mg2+ binding site [chemical binding]; other site 1091494006564 Switch I region; other site 1091494006565 G2 box; other site 1091494006566 G3 box; other site 1091494006567 Switch II region; other site 1091494006568 G4 box; other site 1091494006569 G5 box; other site 1091494006570 Nucleoside recognition; Region: Gate; pfam07670 1091494006571 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1091494006572 Nucleoside recognition; Region: Gate; pfam07670 1091494006573 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1091494006574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494006575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494006576 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494006577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1091494006578 active site residue [active] 1091494006579 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1091494006580 NMT1-like family; Region: NMT1_2; pfam13379 1091494006581 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1091494006582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494006583 dimer interface [polypeptide binding]; other site 1091494006584 conserved gate region; other site 1091494006585 putative PBP binding loops; other site 1091494006586 ABC-ATPase subunit interface; other site 1091494006587 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1091494006588 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1091494006589 Walker A/P-loop; other site 1091494006590 ATP binding site [chemical binding]; other site 1091494006591 Q-loop/lid; other site 1091494006592 ABC transporter signature motif; other site 1091494006593 Walker B; other site 1091494006594 D-loop; other site 1091494006595 H-loop/switch region; other site 1091494006596 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1091494006597 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1091494006598 Walker A/P-loop; other site 1091494006599 ATP binding site [chemical binding]; other site 1091494006600 Q-loop/lid; other site 1091494006601 ABC transporter signature motif; other site 1091494006602 Walker B; other site 1091494006603 D-loop; other site 1091494006604 H-loop/switch region; other site 1091494006605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1091494006606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494006607 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1091494006608 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1091494006609 [4Fe-4S] binding site [ion binding]; other site 1091494006610 molybdopterin cofactor binding site; other site 1091494006611 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1091494006612 molybdopterin cofactor binding site; other site 1091494006613 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1091494006614 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1091494006615 active site 1091494006616 barstar interaction site; other site 1091494006617 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1091494006618 putative RNAase interaction site [polypeptide binding]; other site 1091494006619 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1091494006620 Part of AAA domain; Region: AAA_19; pfam13245 1091494006621 Family description; Region: UvrD_C_2; pfam13538 1091494006622 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1091494006623 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1091494006624 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1091494006625 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1091494006626 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1091494006627 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1091494006628 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1091494006629 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1091494006630 DsbD alpha interface [polypeptide binding]; other site 1091494006631 catalytic residues [active] 1091494006632 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1091494006633 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494006634 catalytic residues [active] 1091494006635 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1091494006636 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1091494006637 trimer interface [polypeptide binding]; other site 1091494006638 active site 1091494006639 dimer interface [polypeptide binding]; other site 1091494006640 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1091494006641 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091494006642 carboxyltransferase (CT) interaction site; other site 1091494006643 biotinylation site [posttranslational modification]; other site 1091494006644 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1091494006645 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091494006646 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091494006647 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1091494006648 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1091494006649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006650 S-adenosylmethionine binding site [chemical binding]; other site 1091494006651 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1091494006652 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1091494006653 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1091494006654 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1091494006655 putative RNA binding site [nucleotide binding]; other site 1091494006656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006657 S-adenosylmethionine binding site [chemical binding]; other site 1091494006658 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1091494006659 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1091494006660 FMN binding site [chemical binding]; other site 1091494006661 active site 1091494006662 catalytic residues [active] 1091494006663 substrate binding site [chemical binding]; other site 1091494006664 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1091494006665 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1091494006666 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1091494006667 purine monophosphate binding site [chemical binding]; other site 1091494006668 dimer interface [polypeptide binding]; other site 1091494006669 putative catalytic residues [active] 1091494006670 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1091494006671 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1091494006672 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1091494006673 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1091494006674 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1091494006675 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1091494006676 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1091494006677 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1091494006678 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1091494006679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494006680 Walker A/P-loop; other site 1091494006681 ATP binding site [chemical binding]; other site 1091494006682 Q-loop/lid; other site 1091494006683 ABC transporter signature motif; other site 1091494006684 Walker B; other site 1091494006685 D-loop; other site 1091494006686 H-loop/switch region; other site 1091494006687 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1091494006688 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1091494006689 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1091494006690 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1091494006691 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1091494006692 P loop; other site 1091494006693 GTP binding site [chemical binding]; other site 1091494006694 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1091494006695 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1091494006696 Subunit III/VIIa interface [polypeptide binding]; other site 1091494006697 Phospholipid binding site [chemical binding]; other site 1091494006698 Subunit I/III interface [polypeptide binding]; other site 1091494006699 Subunit III/VIb interface [polypeptide binding]; other site 1091494006700 Subunit III/VIa interface; other site 1091494006701 Subunit III/Vb interface [polypeptide binding]; other site 1091494006702 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1091494006703 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 1091494006704 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1091494006705 Subunit I/III interface [polypeptide binding]; other site 1091494006706 D-pathway; other site 1091494006707 Subunit I/VIIc interface [polypeptide binding]; other site 1091494006708 Subunit I/IV interface [polypeptide binding]; other site 1091494006709 Subunit I/II interface [polypeptide binding]; other site 1091494006710 Low-spin heme (heme a) binding site [chemical binding]; other site 1091494006711 Subunit I/VIIa interface [polypeptide binding]; other site 1091494006712 Subunit I/VIa interface [polypeptide binding]; other site 1091494006713 Dimer interface; other site 1091494006714 Putative water exit pathway; other site 1091494006715 Binuclear center (heme a3/CuB) [ion binding]; other site 1091494006716 K-pathway; other site 1091494006717 Subunit I/Vb interface [polypeptide binding]; other site 1091494006718 Putative proton exit pathway; other site 1091494006719 Subunit I/VIb interface; other site 1091494006720 Subunit I/VIc interface [polypeptide binding]; other site 1091494006721 Electron transfer pathway; other site 1091494006722 Subunit I/VIIIb interface [polypeptide binding]; other site 1091494006723 Subunit I/VIIb interface [polypeptide binding]; other site 1091494006724 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1091494006725 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1091494006726 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1091494006727 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1091494006728 Hemerythrin; Region: Hemerythrin; cd12107 1091494006729 Fe binding site [ion binding]; other site 1091494006730 AAA domain; Region: AAA_26; pfam13500 1091494006731 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1091494006732 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1091494006733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006734 S-adenosylmethionine binding site [chemical binding]; other site 1091494006735 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494006736 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1091494006737 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1091494006738 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1091494006739 substrate-cofactor binding pocket; other site 1091494006740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494006741 catalytic residue [active] 1091494006742 biotin synthase; Region: bioB; TIGR00433 1091494006743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494006744 FeS/SAM binding site; other site 1091494006745 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1091494006746 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1091494006747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494006748 active site 1091494006749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494006750 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091494006751 Walker A motif; other site 1091494006752 ATP binding site [chemical binding]; other site 1091494006753 Walker B motif; other site 1091494006754 arginine finger; other site 1091494006755 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494006756 HSP70 interaction site [polypeptide binding]; other site 1091494006757 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494006758 Sel1-like repeats; Region: SEL1; smart00671 1091494006759 Sel1-like repeats; Region: SEL1; smart00671 1091494006760 Sel1-like repeats; Region: SEL1; smart00671 1091494006761 Sel1-like repeats; Region: SEL1; smart00671 1091494006762 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1091494006763 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1091494006764 NAD binding site [chemical binding]; other site 1091494006765 substrate binding site [chemical binding]; other site 1091494006766 homodimer interface [polypeptide binding]; other site 1091494006767 active site 1091494006768 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1091494006769 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091494006770 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1091494006771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494006772 Walker A/P-loop; other site 1091494006773 ATP binding site [chemical binding]; other site 1091494006774 Q-loop/lid; other site 1091494006775 ABC transporter signature motif; other site 1091494006776 Walker B; other site 1091494006777 D-loop; other site 1091494006778 H-loop/switch region; other site 1091494006779 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1091494006780 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494006781 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1091494006782 structural tetrad; other site 1091494006783 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1091494006784 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1091494006785 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1091494006786 ligand binding site [chemical binding]; other site 1091494006787 PilZ domain; Region: PilZ; pfam07238 1091494006788 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1091494006789 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1091494006790 MOSC domain; Region: MOSC; pfam03473 1091494006791 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1091494006792 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1091494006793 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1091494006794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091494006795 active site 1091494006796 HIGH motif; other site 1091494006797 nucleotide binding site [chemical binding]; other site 1091494006798 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1091494006799 KMSKS motif; other site 1091494006800 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1091494006801 CHASE domain; Region: CHASE; pfam03924 1091494006802 PAS domain S-box; Region: sensory_box; TIGR00229 1091494006803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006804 putative active site [active] 1091494006805 heme pocket [chemical binding]; other site 1091494006806 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494006807 GAF domain; Region: GAF; pfam01590 1091494006808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006809 PAS fold; Region: PAS_3; pfam08447 1091494006810 putative active site [active] 1091494006811 heme pocket [chemical binding]; other site 1091494006812 PAS fold; Region: PAS_3; pfam08447 1091494006813 PAS domain S-box; Region: sensory_box; TIGR00229 1091494006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006815 putative active site [active] 1091494006816 heme pocket [chemical binding]; other site 1091494006817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006818 PAS domain; Region: PAS_9; pfam13426 1091494006819 putative active site [active] 1091494006820 heme pocket [chemical binding]; other site 1091494006821 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494006822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494006823 metal binding site [ion binding]; metal-binding site 1091494006824 active site 1091494006825 I-site; other site 1091494006826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494006827 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1091494006828 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1091494006829 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1091494006830 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1091494006831 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1091494006832 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1091494006833 active site 1091494006834 catalytic residues [active] 1091494006835 metal binding site [ion binding]; metal-binding site 1091494006836 homodimer binding site [polypeptide binding]; other site 1091494006837 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1091494006838 carboxyltransferase (CT) interaction site; other site 1091494006839 biotinylation site [posttranslational modification]; other site 1091494006840 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1091494006841 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1091494006842 phosphate acetyltransferase; Reviewed; Region: PRK05632 1091494006843 DRTGG domain; Region: DRTGG; pfam07085 1091494006844 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1091494006845 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1091494006846 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1091494006847 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494006848 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494006849 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494006850 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494006851 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1091494006852 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494006853 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494006854 putative active site [active] 1091494006855 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1091494006856 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091494006857 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1091494006858 Patatin-like phospholipase; Region: Patatin; pfam01734 1091494006859 active site 1091494006860 nucleophile elbow; other site 1091494006861 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 1091494006862 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1091494006863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1091494006864 AIPR protein; Region: AIPR; pfam10592 1091494006865 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494006866 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494006867 Integrase core domain; Region: rve; pfam00665 1091494006868 Integrase core domain; Region: rve_3; pfam13683 1091494006869 Transposase; Region: HTH_Tnp_1; cl17663 1091494006870 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 12549933, 12860127, 20068850, 10739946, 20245547, 20347927; Product type e : enzyme 1091494006871 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 12549933, 12860127, 20068850, 10739946, 20245547, 20347927; Product type e : enzyme 1091494006872 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1091494006873 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1091494006874 trimerization site [polypeptide binding]; other site 1091494006875 active site 1091494006876 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1091494006877 NifU-like domain; Region: NifU; cl00484 1091494006878 NifZ domain; Region: NifZ; pfam04319 1091494006879 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1091494006880 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1091494006881 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1091494006882 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1091494006883 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1091494006884 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1091494006885 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091494006886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1091494006887 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1091494006888 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1091494006889 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1091494006890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494006891 dimer interface [polypeptide binding]; other site 1091494006892 conserved gate region; other site 1091494006893 putative PBP binding loops; other site 1091494006894 ABC-ATPase subunit interface; other site 1091494006895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494006896 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1091494006897 Walker A/P-loop; other site 1091494006898 ATP binding site [chemical binding]; other site 1091494006899 Q-loop/lid; other site 1091494006900 ABC transporter signature motif; other site 1091494006901 Walker B; other site 1091494006902 D-loop; other site 1091494006903 H-loop/switch region; other site 1091494006904 TOBE domain; Region: TOBE; pfam03459 1091494006905 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1091494006906 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1091494006907 homodimer interface [polypeptide binding]; other site 1091494006908 metal binding site [ion binding]; metal-binding site 1091494006909 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1091494006910 homodimer interface [polypeptide binding]; other site 1091494006911 active site 1091494006912 putative chemical substrate binding site [chemical binding]; other site 1091494006913 metal binding site [ion binding]; metal-binding site 1091494006914 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1091494006915 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091494006916 substrate binding site [chemical binding]; other site 1091494006917 ATP binding site [chemical binding]; other site 1091494006918 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1091494006919 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1091494006920 lipoyl attachment site [posttranslational modification]; other site 1091494006921 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1091494006922 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1091494006923 Protein export membrane protein; Region: SecD_SecF; cl14618 1091494006924 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1091494006925 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1091494006926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1091494006927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494006928 dimer interface [polypeptide binding]; other site 1091494006929 putative CheW interface [polypeptide binding]; other site 1091494006930 NMT1/THI5 like; Region: NMT1; pfam09084 1091494006931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1091494006932 substrate binding pocket [chemical binding]; other site 1091494006933 membrane-bound complex binding site; other site 1091494006934 hinge residues; other site 1091494006935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1091494006936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494006937 substrate binding pocket [chemical binding]; other site 1091494006938 membrane-bound complex binding site; other site 1091494006939 hinge residues; other site 1091494006940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494006941 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1091494006942 substrate binding pocket [chemical binding]; other site 1091494006943 membrane-bound complex binding site; other site 1091494006944 hinge residues; other site 1091494006945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494006947 putative active site [active] 1091494006948 heme pocket [chemical binding]; other site 1091494006949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494006950 dimer interface [polypeptide binding]; other site 1091494006951 phosphorylation site [posttranslational modification] 1091494006952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494006953 ATP binding site [chemical binding]; other site 1091494006954 Mg2+ binding site [ion binding]; other site 1091494006955 G-X-G motif; other site 1091494006956 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494006957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494006958 active site 1091494006959 phosphorylation site [posttranslational modification] 1091494006960 intermolecular recognition site; other site 1091494006961 dimerization interface [polypeptide binding]; other site 1091494006962 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494006963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494006964 active site 1091494006965 phosphorylation site [posttranslational modification] 1091494006966 intermolecular recognition site; other site 1091494006967 dimerization interface [polypeptide binding]; other site 1091494006968 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494006969 Zn2+ binding site [ion binding]; other site 1091494006970 Mg2+ binding site [ion binding]; other site 1091494006971 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1091494006972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494006973 substrate binding pocket [chemical binding]; other site 1091494006974 membrane-bound complex binding site; other site 1091494006975 hinge residues; other site 1091494006976 PAS domain S-box; Region: sensory_box; TIGR00229 1091494006977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494006978 putative active site [active] 1091494006979 heme pocket [chemical binding]; other site 1091494006980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494006981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494006982 metal binding site [ion binding]; metal-binding site 1091494006983 active site 1091494006984 I-site; other site 1091494006985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494006986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494006987 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1091494006988 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1091494006989 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1091494006990 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1091494006991 putative transporter; Validated; Region: PRK03818 1091494006992 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1091494006993 TrkA-C domain; Region: TrkA_C; pfam02080 1091494006994 TrkA-C domain; Region: TrkA_C; pfam02080 1091494006995 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1091494006996 Peptidase family M48; Region: Peptidase_M48; cl12018 1091494006997 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1091494006998 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1091494006999 putative ATP binding site [chemical binding]; other site 1091494007000 putative substrate interface [chemical binding]; other site 1091494007001 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091494007002 active site 1091494007003 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1091494007004 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1091494007005 dimer interface [polypeptide binding]; other site 1091494007006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494007007 catalytic residue [active] 1091494007008 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1091494007009 nucleotide binding site/active site [active] 1091494007010 HIT family signature motif; other site 1091494007011 catalytic residue [active] 1091494007012 recombination protein RecR; Reviewed; Region: recR; PRK00076 1091494007013 RecR protein; Region: RecR; pfam02132 1091494007014 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1091494007015 putative active site [active] 1091494007016 putative metal-binding site [ion binding]; other site 1091494007017 tetramer interface [polypeptide binding]; other site 1091494007018 hypothetical protein; Validated; Region: PRK00153 1091494007019 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 1091494007020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494007021 Walker A motif; other site 1091494007022 ATP binding site [chemical binding]; other site 1091494007023 Walker B motif; other site 1091494007024 arginine finger; other site 1091494007025 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1091494007026 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1091494007027 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1091494007028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1091494007029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494007030 dimer interface [polypeptide binding]; other site 1091494007031 phosphorylation site [posttranslational modification] 1091494007032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007033 ATP binding site [chemical binding]; other site 1091494007034 Mg2+ binding site [ion binding]; other site 1091494007035 G-X-G motif; other site 1091494007036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494007037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494007038 DNA binding residues [nucleotide binding] 1091494007039 dimerization interface [polypeptide binding]; other site 1091494007040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494007041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494007042 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1091494007043 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1091494007044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494007045 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494007046 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494007047 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1091494007048 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1091494007049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494007050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1091494007051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494007052 dimer interface [polypeptide binding]; other site 1091494007053 phosphorylation site [posttranslational modification] 1091494007054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007055 ATP binding site [chemical binding]; other site 1091494007056 Mg2+ binding site [ion binding]; other site 1091494007057 G-X-G motif; other site 1091494007058 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1091494007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007060 active site 1091494007061 phosphorylation site [posttranslational modification] 1091494007062 intermolecular recognition site; other site 1091494007063 dimerization interface [polypeptide binding]; other site 1091494007064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494007065 DNA binding site [nucleotide binding] 1091494007066 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1091494007067 active site clefts [active] 1091494007068 zinc binding site [ion binding]; other site 1091494007069 dimer interface [polypeptide binding]; other site 1091494007070 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494007071 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494007072 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091494007073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091494007074 Ligand Binding Site [chemical binding]; other site 1091494007075 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1091494007076 Ligand Binding Site [chemical binding]; other site 1091494007077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1091494007078 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1091494007079 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494007080 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1091494007081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494007082 motif II; other site 1091494007083 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1091494007084 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 1091494007085 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1091494007086 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1091494007087 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 1091494007088 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494007089 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 1091494007090 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 1091494007091 trimer interface I [polypeptide binding]; other site 1091494007092 putative substrate binding pocket [chemical binding]; other site 1091494007093 trimer interface II [polypeptide binding]; other site 1091494007094 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1091494007095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494007096 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 1091494007097 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 1091494007098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494007099 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1091494007100 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1091494007101 active site 1091494007102 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 1091494007103 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 1091494007104 active site 1091494007105 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 1091494007106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494007107 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 1091494007108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494007109 alanine racemase; Reviewed; Region: alr; PRK00053 1091494007110 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1091494007111 active site 1091494007112 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494007113 substrate binding site [chemical binding]; other site 1091494007114 catalytic residues [active] 1091494007115 dimer interface [polypeptide binding]; other site 1091494007116 replicative DNA helicase; Region: DnaB; TIGR00665 1091494007117 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1091494007118 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1091494007119 Walker A motif; other site 1091494007120 ATP binding site [chemical binding]; other site 1091494007121 Walker B motif; other site 1091494007122 DNA binding loops [nucleotide binding] 1091494007123 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1091494007124 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1091494007125 active site 1091494007126 HIGH motif; other site 1091494007127 dimer interface [polypeptide binding]; other site 1091494007128 KMSKS motif; other site 1091494007129 PilZ domain; Region: PilZ; pfam07238 1091494007130 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1091494007131 active site 1091494007132 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1091494007133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494007134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494007135 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1091494007136 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1091494007137 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494007138 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494007139 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494007140 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1091494007141 AAA domain; Region: AAA_32; pfam13654 1091494007142 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1091494007143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007144 PAS domain; Region: PAS_9; pfam13426 1091494007145 putative active site [active] 1091494007146 heme pocket [chemical binding]; other site 1091494007147 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007149 metal binding site [ion binding]; metal-binding site 1091494007150 active site 1091494007151 I-site; other site 1091494007152 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494007153 PAS fold; Region: PAS_3; pfam08447 1091494007154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007155 putative active site [active] 1091494007156 heme pocket [chemical binding]; other site 1091494007157 PAS domain; Region: PAS_9; pfam13426 1091494007158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1091494007159 Histidine kinase; Region: HisKA_2; pfam07568 1091494007160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007161 ATP binding site [chemical binding]; other site 1091494007162 Mg2+ binding site [ion binding]; other site 1091494007163 G-X-G motif; other site 1091494007164 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1091494007165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007166 active site 1091494007167 phosphorylation site [posttranslational modification] 1091494007168 intermolecular recognition site; other site 1091494007169 dimerization interface [polypeptide binding]; other site 1091494007170 ANTAR domain; Region: ANTAR; pfam03861 1091494007171 PAS fold; Region: PAS_4; pfam08448 1091494007172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007173 putative active site [active] 1091494007174 heme pocket [chemical binding]; other site 1091494007175 PAS domain S-box; Region: sensory_box; TIGR00229 1091494007176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007177 putative active site [active] 1091494007178 heme pocket [chemical binding]; other site 1091494007179 GAF domain; Region: GAF; cl17456 1091494007180 GAF domain; Region: GAF_2; pfam13185 1091494007181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007182 PAS domain; Region: PAS_9; pfam13426 1091494007183 putative active site [active] 1091494007184 heme pocket [chemical binding]; other site 1091494007185 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007187 metal binding site [ion binding]; metal-binding site 1091494007188 active site 1091494007189 I-site; other site 1091494007190 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494007191 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1091494007192 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494007193 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1091494007194 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494007195 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494007196 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 1091494007197 PAS domain; Region: PAS_10; pfam13596 1091494007198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007199 putative active site [active] 1091494007200 heme pocket [chemical binding]; other site 1091494007201 PAS fold; Region: PAS; pfam00989 1091494007202 PAS fold; Region: PAS; pfam00989 1091494007203 CHASE domain; Region: CHASE; pfam03924 1091494007204 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494007205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007206 putative active site [active] 1091494007207 heme pocket [chemical binding]; other site 1091494007208 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494007209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007210 putative active site [active] 1091494007211 heme pocket [chemical binding]; other site 1091494007212 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494007213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007214 putative active site [active] 1091494007215 heme pocket [chemical binding]; other site 1091494007216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007217 PAS domain; Region: PAS_9; pfam13426 1091494007218 putative active site [active] 1091494007219 heme pocket [chemical binding]; other site 1091494007220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494007221 dimer interface [polypeptide binding]; other site 1091494007222 phosphorylation site [posttranslational modification] 1091494007223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007224 ATP binding site [chemical binding]; other site 1091494007225 Mg2+ binding site [ion binding]; other site 1091494007226 G-X-G motif; other site 1091494007227 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494007228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007229 active site 1091494007230 phosphorylation site [posttranslational modification] 1091494007231 intermolecular recognition site; other site 1091494007232 dimerization interface [polypeptide binding]; other site 1091494007233 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494007234 putative binding surface; other site 1091494007235 active site 1091494007236 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494007237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007238 active site 1091494007239 phosphorylation site [posttranslational modification] 1091494007240 intermolecular recognition site; other site 1091494007241 dimerization interface [polypeptide binding]; other site 1091494007242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494007243 Zn2+ binding site [ion binding]; other site 1091494007244 Mg2+ binding site [ion binding]; other site 1091494007245 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091494007246 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1091494007247 NAD binding site [chemical binding]; other site 1091494007248 homodimer interface [polypeptide binding]; other site 1091494007249 active site 1091494007250 putative substrate binding site [chemical binding]; other site 1091494007251 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1091494007252 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1091494007253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494007254 catalytic residue [active] 1091494007255 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1091494007256 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1091494007257 homodimer interface [polypeptide binding]; other site 1091494007258 Walker A motif; other site 1091494007259 ATP binding site [chemical binding]; other site 1091494007260 hydroxycobalamin binding site [chemical binding]; other site 1091494007261 Walker B motif; other site 1091494007262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494007263 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1091494007264 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091494007265 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 1091494007266 nickel binding site [ion binding]; other site 1091494007267 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1091494007268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007269 PAS domain; Region: PAS_9; pfam13426 1091494007270 putative active site [active] 1091494007271 heme pocket [chemical binding]; other site 1091494007272 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1091494007273 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091494007274 G1 box; other site 1091494007275 GTP/Mg2+ binding site [chemical binding]; other site 1091494007276 G2 box; other site 1091494007277 Switch I region; other site 1091494007278 G3 box; other site 1091494007279 Switch II region; other site 1091494007280 G4 box; other site 1091494007281 G5 box; other site 1091494007282 Sporulation related domain; Region: SPOR; pfam05036 1091494007283 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1091494007284 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1091494007285 intersubunit interface [polypeptide binding]; other site 1091494007286 active site 1091494007287 Zn2+ binding site [ion binding]; other site 1091494007288 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1091494007289 Cupin domain; Region: Cupin_2; pfam07883 1091494007290 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1091494007291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494007292 motif II; other site 1091494007293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1091494007294 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1091494007295 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494007296 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1091494007297 Peptidase M15; Region: Peptidase_M15_3; cl01194 1091494007298 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1091494007299 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1091494007300 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1091494007301 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1091494007302 TrkA-N domain; Region: TrkA_N; pfam02254 1091494007303 TrkA-C domain; Region: TrkA_C; pfam02080 1091494007304 Cation transport protein; Region: TrkH; cl17365 1091494007305 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1091494007306 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1091494007307 TrkA-N domain; Region: TrkA_N; pfam02254 1091494007308 TrkA-C domain; Region: TrkA_C; pfam02080 1091494007309 TrkA-N domain; Region: TrkA_N; pfam02254 1091494007310 TrkA-C domain; Region: TrkA_C; pfam02080 1091494007311 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494007312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007313 active site 1091494007314 phosphorylation site [posttranslational modification] 1091494007315 intermolecular recognition site; other site 1091494007316 dimerization interface [polypeptide binding]; other site 1091494007317 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1091494007318 SprA-related family; Region: SprA-related; pfam12118 1091494007319 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1091494007320 Domain of unknown function DUF87; Region: DUF87; pfam01935 1091494007321 FeoC like transcriptional regulator; Region: FeoC; pfam09012 1091494007322 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1091494007323 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1091494007324 G1 box; other site 1091494007325 GTP/Mg2+ binding site [chemical binding]; other site 1091494007326 Switch I region; other site 1091494007327 G2 box; other site 1091494007328 G3 box; other site 1091494007329 Switch II region; other site 1091494007330 G4 box; other site 1091494007331 G5 box; other site 1091494007332 Nucleoside recognition; Region: Gate; pfam07670 1091494007333 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1091494007334 Nucleoside recognition; Region: Gate; pfam07670 1091494007335 FeoA domain; Region: FeoA; pfam04023 1091494007336 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1091494007337 IHF dimer interface [polypeptide binding]; other site 1091494007338 IHF - DNA interface [nucleotide binding]; other site 1091494007339 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1091494007340 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1091494007341 RNA binding site [nucleotide binding]; other site 1091494007342 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1091494007343 RNA binding site [nucleotide binding]; other site 1091494007344 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1091494007345 RNA binding site [nucleotide binding]; other site 1091494007346 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1091494007347 RNA binding site [nucleotide binding]; other site 1091494007348 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1091494007349 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1091494007350 RNA binding site [nucleotide binding]; other site 1091494007351 cytidylate kinase; Provisional; Region: cmk; PRK00023 1091494007352 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1091494007353 CMP-binding site; other site 1091494007354 The sites determining sugar specificity; other site 1091494007355 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1091494007356 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1091494007357 hinge; other site 1091494007358 active site 1091494007359 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1091494007360 prephenate dehydrogenase; Validated; Region: PRK08507 1091494007361 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1091494007362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494007363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494007364 homodimer interface [polypeptide binding]; other site 1091494007365 catalytic residue [active] 1091494007366 Chorismate mutase type II; Region: CM_2; cl00693 1091494007367 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1091494007368 Prephenate dehydratase; Region: PDT; pfam00800 1091494007369 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1091494007370 putative L-Phe binding site [chemical binding]; other site 1091494007371 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1091494007372 homodimer interface [polypeptide binding]; other site 1091494007373 substrate-cofactor binding pocket; other site 1091494007374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494007375 catalytic residue [active] 1091494007376 DNA gyrase subunit A; Validated; Region: PRK05560 1091494007377 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1091494007378 CAP-like domain; other site 1091494007379 active site 1091494007380 primary dimer interface [polypeptide binding]; other site 1091494007381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007385 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007386 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1091494007387 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1091494007388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494007389 FeS/SAM binding site; other site 1091494007390 HemN C-terminal domain; Region: HemN_C; pfam06969 1091494007391 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1091494007392 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1091494007393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494007394 binding surface 1091494007395 TPR motif; other site 1091494007396 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1091494007397 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1091494007398 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494007399 catalytic residues [active] 1091494007400 central insert; other site 1091494007401 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1091494007402 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1091494007403 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1091494007404 heme exporter protein CcmC; Region: ccmC; TIGR01191 1091494007405 heme exporter protein CcmB; Region: ccmB; TIGR01190 1091494007406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494007407 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1091494007408 Walker A/P-loop; other site 1091494007409 ATP binding site [chemical binding]; other site 1091494007410 Q-loop/lid; other site 1091494007411 ABC transporter signature motif; other site 1091494007412 Walker B; other site 1091494007413 D-loop; other site 1091494007414 H-loop/switch region; other site 1091494007415 Putative glucoamylase; Region: Glycoamylase; pfam10091 1091494007416 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1091494007417 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1091494007418 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1091494007419 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1091494007420 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1091494007421 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1091494007422 NodB motif; other site 1091494007423 active site 1091494007424 catalytic site [active] 1091494007425 metal binding site [ion binding]; metal-binding site 1091494007426 TRL-like protein family; Region: TRL; pfam13146 1091494007427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1091494007428 putative acyl-acceptor binding pocket; other site 1091494007429 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1091494007430 Ligand binding site; other site 1091494007431 Putative Catalytic site; other site 1091494007432 DXD motif; other site 1091494007433 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1091494007434 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1091494007435 Active site cavity [active] 1091494007436 catalytic acid [active] 1091494007437 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494007438 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494007439 ligand binding site [chemical binding]; other site 1091494007440 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091494007441 non-specific DNA interactions [nucleotide binding]; other site 1091494007442 DNA binding site [nucleotide binding] 1091494007443 sequence specific DNA binding site [nucleotide binding]; other site 1091494007444 putative cAMP binding site [chemical binding]; other site 1091494007445 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494007446 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494007447 ligand binding site [chemical binding]; other site 1091494007448 flexible hinge region; other site 1091494007449 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1091494007450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007451 PAS domain; Region: PAS_9; pfam13426 1091494007452 putative active site [active] 1091494007453 heme pocket [chemical binding]; other site 1091494007454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1091494007455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494007456 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1091494007457 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1091494007458 CsbD-like; Region: CsbD; pfam05532 1091494007459 CsbD-like; Region: CsbD; cl17424 1091494007460 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091494007461 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091494007462 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494007463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494007464 ligand binding site [chemical binding]; other site 1091494007465 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1091494007466 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1091494007467 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1091494007468 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1091494007469 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494007470 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1091494007471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007472 PAS domain; Region: PAS_9; pfam13426 1091494007473 putative active site [active] 1091494007474 heme pocket [chemical binding]; other site 1091494007475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007477 metal binding site [ion binding]; metal-binding site 1091494007478 active site 1091494007479 I-site; other site 1091494007480 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494007481 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1091494007482 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494007483 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494007484 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1091494007485 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494007486 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1091494007487 PAS domain; Region: PAS_10; pfam13596 1091494007488 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1091494007489 periplasmic protein; Provisional; Region: PRK10568 1091494007490 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1091494007491 BON domain; Region: BON; pfam04972 1091494007492 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1091494007493 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1091494007494 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494007495 ligand binding site [chemical binding]; other site 1091494007496 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1091494007497 30S subunit binding site; other site 1091494007498 BON domain; Region: BON; pfam04972 1091494007499 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1091494007500 dinuclear metal binding motif [ion binding]; other site 1091494007501 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1091494007502 EF-hand domain pair; Region: EF_hand_5; pfam13499 1091494007503 Ca2+ binding site [ion binding]; other site 1091494007504 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1091494007505 Predicted membrane protein [Function unknown]; Region: COG4325 1091494007506 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1091494007507 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 1091494007508 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494007509 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494007510 Integrase core domain; Region: rve; pfam00665 1091494007511 Integrase core domain; Region: rve_3; pfam13683 1091494007512 Transposase; Region: HTH_Tnp_1; cl17663 1091494007513 Protein of unknown function (DUF502); Region: DUF502; cl01107 1091494007514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007516 metal binding site [ion binding]; metal-binding site 1091494007517 active site 1091494007518 I-site; other site 1091494007519 hydroperoxidase II; Provisional; Region: katE; PRK11249 1091494007520 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1091494007521 tetramer interface [polypeptide binding]; other site 1091494007522 heme binding pocket [chemical binding]; other site 1091494007523 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1091494007524 domain interactions; other site 1091494007525 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1091494007526 Hemerythrin-like domain; Region: Hr-like; cd12108 1091494007527 BON domain; Region: BON; pfam04972 1091494007528 putative phosphoketolase; Provisional; Region: PRK05261 1091494007529 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1091494007530 TPP-binding site; other site 1091494007531 XFP C-terminal domain; Region: XFP_C; pfam09363 1091494007532 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1091494007533 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1091494007534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494007535 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1091494007536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494007537 active site 1091494007538 motif I; other site 1091494007539 motif II; other site 1091494007540 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1091494007541 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1091494007542 PRC-barrel domain; Region: PRC; pfam05239 1091494007543 PRC-barrel domain; Region: PRC; pfam05239 1091494007544 Domain of unknown function DUF302; Region: DUF302; cl01364 1091494007545 Transposase; Region: HTH_Tnp_1; cl17663 1091494007546 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494007547 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494007548 Integrase core domain; Region: rve; pfam00665 1091494007549 Integrase core domain; Region: rve_3; pfam13683 1091494007550 CsbD-like; Region: CsbD; cl17424 1091494007551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007553 metal binding site [ion binding]; metal-binding site 1091494007554 active site 1091494007555 I-site; other site 1091494007556 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1091494007557 BON domain; Region: BON; pfam04972 1091494007558 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1091494007559 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1091494007560 CsbD-like; Region: CsbD; cl17424 1091494007561 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1091494007562 rRNA binding site [nucleotide binding]; other site 1091494007563 predicted 30S ribosome binding site; other site 1091494007564 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1091494007565 Clp amino terminal domain; Region: Clp_N; pfam02861 1091494007566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494007567 Walker A motif; other site 1091494007568 ATP binding site [chemical binding]; other site 1091494007569 Walker B motif; other site 1091494007570 arginine finger; other site 1091494007571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494007572 Walker A motif; other site 1091494007573 ATP binding site [chemical binding]; other site 1091494007574 Walker B motif; other site 1091494007575 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1091494007576 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1091494007577 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1091494007578 nudix motif; other site 1091494007579 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1091494007580 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1091494007581 Ligand Binding Site [chemical binding]; other site 1091494007582 adenylosuccinate lyase; Provisional; Region: PRK09285 1091494007583 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1091494007584 tetramer interface [polypeptide binding]; other site 1091494007585 active site 1091494007586 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1091494007587 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1091494007588 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1091494007589 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1091494007590 Evidence 7 : Gene remnant 1091494007591 Evidence 7 : Gene remnant 1091494007592 Evidence 7 : Gene remnant 1091494007593 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1091494007594 G1 box; other site 1091494007595 GTP/Mg2+ binding site [chemical binding]; other site 1091494007596 G2 box; other site 1091494007597 Switch I region; other site 1091494007598 G3 box; other site 1091494007599 Switch II region; other site 1091494007600 G4 box; other site 1091494007601 G5 box; other site 1091494007602 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1091494007603 GTP/Mg2+ binding site [chemical binding]; other site 1091494007604 G5 box; other site 1091494007605 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091494007606 G1 box; other site 1091494007607 G1 box; other site 1091494007608 GTP/Mg2+ binding site [chemical binding]; other site 1091494007609 Switch I region; other site 1091494007610 G2 box; other site 1091494007611 G2 box; other site 1091494007612 Switch I region; other site 1091494007613 G3 box; other site 1091494007614 Switch II region; other site 1091494007615 G4 box; other site 1091494007616 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1091494007617 Outer membrane efflux protein; Region: OEP; pfam02321 1091494007618 Outer membrane efflux protein; Region: OEP; pfam02321 1091494007619 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494007620 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494007621 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1091494007622 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1091494007623 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1091494007624 inhibitor site; inhibition site 1091494007625 active site 1091494007626 dimer interface [polypeptide binding]; other site 1091494007627 catalytic residue [active] 1091494007628 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1091494007629 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1091494007630 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1091494007631 5-oxoprolinase; Region: PLN02666 1091494007632 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1091494007633 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1091494007634 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1091494007635 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1091494007636 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1091494007637 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1091494007638 Ligand Binding Site [chemical binding]; other site 1091494007639 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1091494007640 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1091494007641 dimer interface [polypeptide binding]; other site 1091494007642 active site 1091494007643 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1091494007644 active site 1 [active] 1091494007645 dimer interface [polypeptide binding]; other site 1091494007646 active site 2 [active] 1091494007647 lytic murein transglycosylase; Provisional; Region: PRK11619 1091494007648 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494007649 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494007650 catalytic residue [active] 1091494007651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494007652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494007653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1091494007654 Walker A/P-loop; other site 1091494007655 ATP binding site [chemical binding]; other site 1091494007656 Q-loop/lid; other site 1091494007657 ABC transporter signature motif; other site 1091494007658 Walker B; other site 1091494007659 D-loop; other site 1091494007660 H-loop/switch region; other site 1091494007661 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1091494007662 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1091494007663 active site 1091494007664 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1091494007665 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1091494007666 active site 1091494007667 Zn binding site [ion binding]; other site 1091494007668 hypothetical protein; Provisional; Region: PRK05170 1091494007669 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1091494007670 active site 1091494007671 putative catalytic site [active] 1091494007672 DNA binding site [nucleotide binding] 1091494007673 putative phosphate binding site [ion binding]; other site 1091494007674 metal binding site A [ion binding]; metal-binding site 1091494007675 AP binding site [nucleotide binding]; other site 1091494007676 metal binding site B [ion binding]; metal-binding site 1091494007677 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 1091494007678 ligand binding site [chemical binding]; other site 1091494007679 active site 1091494007680 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1091494007681 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1091494007682 Transposase; Region: HTH_Tnp_1; cl17663 1091494007683 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494007684 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494007685 Integrase core domain; Region: rve; pfam00665 1091494007686 Integrase core domain; Region: rve_3; pfam13683 1091494007687 MASE1; Region: MASE1; cl17823 1091494007688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007689 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494007690 putative active site [active] 1091494007691 heme pocket [chemical binding]; other site 1091494007692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007693 putative active site [active] 1091494007694 heme pocket [chemical binding]; other site 1091494007695 PAS domain S-box; Region: sensory_box; TIGR00229 1091494007696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007697 putative active site [active] 1091494007698 heme pocket [chemical binding]; other site 1091494007699 PAS domain S-box; Region: sensory_box; TIGR00229 1091494007700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007701 putative active site [active] 1091494007702 heme pocket [chemical binding]; other site 1091494007703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494007704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1091494007705 dimer interface [polypeptide binding]; other site 1091494007706 phosphorylation site [posttranslational modification] 1091494007707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007708 ATP binding site [chemical binding]; other site 1091494007709 Mg2+ binding site [ion binding]; other site 1091494007710 G-X-G motif; other site 1091494007711 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494007712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007713 active site 1091494007714 phosphorylation site [posttranslational modification] 1091494007715 intermolecular recognition site; other site 1091494007716 dimerization interface [polypeptide binding]; other site 1091494007717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1091494007718 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494007719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007720 active site 1091494007721 phosphorylation site [posttranslational modification] 1091494007722 intermolecular recognition site; other site 1091494007723 dimerization interface [polypeptide binding]; other site 1091494007724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007725 PAS domain; Region: PAS_9; pfam13426 1091494007726 putative active site [active] 1091494007727 heme pocket [chemical binding]; other site 1091494007728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007730 metal binding site [ion binding]; metal-binding site 1091494007731 active site 1091494007732 I-site; other site 1091494007733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494007734 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1091494007735 CPxP motif; other site 1091494007736 siroheme synthase; Provisional; Region: cysG; PRK10637 1091494007737 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1091494007738 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1091494007739 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1091494007740 active site 1091494007741 SAM binding site [chemical binding]; other site 1091494007742 homodimer interface [polypeptide binding]; other site 1091494007743 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1091494007744 structural tetrad; other site 1091494007745 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1091494007746 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1091494007747 structural tetrad; other site 1091494007748 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1091494007749 argininosuccinate synthase; Provisional; Region: PRK13820 1091494007750 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1091494007751 ANP binding site [chemical binding]; other site 1091494007752 Substrate Binding Site II [chemical binding]; other site 1091494007753 Substrate Binding Site I [chemical binding]; other site 1091494007754 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1091494007755 GIY-YIG motif/motif A; other site 1091494007756 putative active site [active] 1091494007757 putative metal binding site [ion binding]; other site 1091494007758 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1091494007759 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 1091494007760 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1091494007761 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1091494007762 ligand binding site [chemical binding]; other site 1091494007763 homodimer interface [polypeptide binding]; other site 1091494007764 NAD(P) binding site [chemical binding]; other site 1091494007765 trimer interface B [polypeptide binding]; other site 1091494007766 trimer interface A [polypeptide binding]; other site 1091494007767 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1091494007768 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 1091494007769 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1091494007770 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494007771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007772 active site 1091494007773 phosphorylation site [posttranslational modification] 1091494007774 intermolecular recognition site; other site 1091494007775 dimerization interface [polypeptide binding]; other site 1091494007776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494007777 Zn2+ binding site [ion binding]; other site 1091494007778 Mg2+ binding site [ion binding]; other site 1091494007779 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1091494007780 Beta-lactamase; Region: Beta-lactamase; pfam00144 1091494007781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1091494007782 membrane-bound complex binding site; other site 1091494007783 hinge residues; other site 1091494007784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494007785 membrane-bound complex binding site; other site 1091494007786 hinge residues; other site 1091494007787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494007788 dimerization interface [polypeptide binding]; other site 1091494007789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494007790 dimer interface [polypeptide binding]; other site 1091494007791 phosphorylation site [posttranslational modification] 1091494007792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494007793 ATP binding site [chemical binding]; other site 1091494007794 Mg2+ binding site [ion binding]; other site 1091494007795 G-X-G motif; other site 1091494007796 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494007797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494007798 active site 1091494007799 phosphorylation site [posttranslational modification] 1091494007800 intermolecular recognition site; other site 1091494007801 dimerization interface [polypeptide binding]; other site 1091494007802 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1091494007803 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1091494007804 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 1091494007805 active site 1091494007806 catalytic site [active] 1091494007807 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1091494007808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494007809 dimerization interface [polypeptide binding]; other site 1091494007810 PAS domain S-box; Region: sensory_box; TIGR00229 1091494007811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494007812 putative active site [active] 1091494007813 heme pocket [chemical binding]; other site 1091494007814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007816 metal binding site [ion binding]; metal-binding site 1091494007817 active site 1091494007818 I-site; other site 1091494007819 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494007820 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1091494007821 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1091494007822 active site 1091494007823 metal binding site [ion binding]; metal-binding site 1091494007824 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1091494007825 SelR domain; Region: SelR; pfam01641 1091494007826 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1091494007827 putative ADP-ribose binding site [chemical binding]; other site 1091494007828 putative active site [active] 1091494007829 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 1091494007830 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1091494007831 O-Antigen ligase; Region: Wzy_C; pfam04932 1091494007832 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1091494007833 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1091494007834 homodimer interface [polypeptide binding]; other site 1091494007835 substrate-cofactor binding pocket; other site 1091494007836 catalytic residue [active] 1091494007837 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1091494007838 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091494007839 metal binding triad; other site 1091494007840 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091494007841 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091494007842 metal binding triad; other site 1091494007843 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091494007844 inner membrane transport permease; Provisional; Region: PRK15066 1091494007845 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1091494007846 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1091494007847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494007848 Walker A/P-loop; other site 1091494007849 ATP binding site [chemical binding]; other site 1091494007850 Q-loop/lid; other site 1091494007851 ABC transporter signature motif; other site 1091494007852 Walker B; other site 1091494007853 D-loop; other site 1091494007854 H-loop/switch region; other site 1091494007855 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1091494007856 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1091494007857 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 1091494007858 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1091494007859 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1091494007860 Transposase; Region: HTH_Tnp_1; cl17663 1091494007861 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494007862 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494007863 Integrase core domain; Region: rve; pfam00665 1091494007864 Integrase core domain; Region: rve_3; pfam13683 1091494007865 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1091494007866 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1091494007867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1091494007868 HSP70 interaction site [polypeptide binding]; other site 1091494007869 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1091494007870 substrate binding site [polypeptide binding]; other site 1091494007871 dimer interface [polypeptide binding]; other site 1091494007872 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1091494007873 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1091494007874 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1091494007875 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1091494007876 L-aspartate oxidase; Provisional; Region: PRK06175 1091494007877 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1091494007878 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1091494007879 putative SdhC subunit interface [polypeptide binding]; other site 1091494007880 putative proximal heme binding site [chemical binding]; other site 1091494007881 putative Iron-sulfur protein interface [polypeptide binding]; other site 1091494007882 putative proximal quinone binding site; other site 1091494007883 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1091494007884 Iron-sulfur protein interface; other site 1091494007885 proximal quinone binding site [chemical binding]; other site 1091494007886 SdhD (CybS) interface [polypeptide binding]; other site 1091494007887 proximal heme binding site [chemical binding]; other site 1091494007888 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1091494007889 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494007890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494007891 metal binding site [ion binding]; metal-binding site 1091494007892 active site 1091494007893 I-site; other site 1091494007894 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1091494007895 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1091494007896 Ligand Binding Site [chemical binding]; other site 1091494007897 Molecular Tunnel; other site 1091494007898 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 1091494007899 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1091494007900 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1091494007901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1091494007902 active site 1091494007903 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494007904 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1091494007905 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 1091494007906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494007907 putative active site [active] 1091494007908 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494007909 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1091494007910 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1091494007911 active site 1091494007912 NTP binding site [chemical binding]; other site 1091494007913 metal binding triad [ion binding]; metal-binding site 1091494007914 antibiotic binding site [chemical binding]; other site 1091494007915 Protein of unknown function DUF86; Region: DUF86; cl01031 1091494007916 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494007917 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1091494007918 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1091494007919 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1091494007920 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1091494007921 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1091494007922 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1091494007923 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1091494007924 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 1091494007925 putative active site [active] 1091494007926 putative cosubstrate binding site; other site 1091494007927 putative substrate binding site [chemical binding]; other site 1091494007928 catalytic site [active] 1091494007929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494007930 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1091494007931 acyl-activating enzyme (AAE) consensus motif; other site 1091494007932 active site 1091494007933 AMP binding site [chemical binding]; other site 1091494007934 CoA binding site [chemical binding]; other site 1091494007935 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 1091494007936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494007937 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 1091494007938 acyl-activating enzyme (AAE) consensus motif; other site 1091494007939 acyl-activating enzyme (AAE) consensus motif; other site 1091494007940 putative AMP binding site [chemical binding]; other site 1091494007941 putative active site [active] 1091494007942 putative CoA binding site [chemical binding]; other site 1091494007943 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1091494007944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1091494007945 dimer interface [polypeptide binding]; other site 1091494007946 active site 1091494007947 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494007948 catalytic residues [active] 1091494007949 substrate binding site [chemical binding]; other site 1091494007950 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1091494007951 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1091494007952 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091494007953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494007955 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494007956 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494007957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494007958 S-adenosylmethionine binding site [chemical binding]; other site 1091494007959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1091494007960 Transposase; Region: HTH_Tnp_1; pfam01527 1091494007961 potential frameshift: common BLAST hit: gi|344201234|ref|YP_004785560.1| integrase catalytic subunit 1091494007962 HTH-like domain; Region: HTH_21; pfam13276 1091494007963 Integrase core domain; Region: rve; pfam00665 1091494007964 Integrase core domain; Region: rve_3; pfam13683 1091494007965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494007966 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091494007967 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494007968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494007969 TPR repeat; Region: TPR_11; pfam13414 1091494007970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494007971 binding surface 1091494007972 TPR motif; other site 1091494007973 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1091494007974 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327 1091494007975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1091494007976 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1091494007977 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1091494007978 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1091494007979 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1091494007980 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1091494007981 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1091494007982 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494007983 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1091494007984 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494007985 putative homodimer interface [polypeptide binding]; other site 1091494007986 O-Antigen ligase; Region: Wzy_C; cl04850 1091494007987 potential frameshift: common BLAST hit: gi|30248800|ref|NP_840870.1| capsular polysaccharide biosynthesis protein CapK 1091494007988 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1091494007989 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494007990 AMP binding site [chemical binding]; other site 1091494007991 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494007992 acyl-activating enzyme (AAE) consensus motif; other site 1091494007993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1091494007994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494007995 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1091494007996 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1091494007997 putative ADP-binding pocket [chemical binding]; other site 1091494007998 Sulfatase; Region: Sulfatase; cl17466 1091494007999 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1091494008000 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1091494008001 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091494008002 inhibitor-cofactor binding pocket; inhibition site 1091494008003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494008004 catalytic residue [active] 1091494008005 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1091494008006 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494008007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494008008 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1091494008009 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1091494008010 WbqC-like protein family; Region: WbqC; pfam08889 1091494008011 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1091494008012 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1091494008013 Ligand binding site; other site 1091494008014 Putative Catalytic site; other site 1091494008015 DXD motif; other site 1091494008016 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1091494008017 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1091494008018 substrate binding site; other site 1091494008019 tetramer interface; other site 1091494008020 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1091494008021 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1091494008022 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494008023 putative active site [active] 1091494008024 Sulfatase; Region: Sulfatase; cl17466 1091494008025 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1091494008026 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1091494008027 Walker A/P-loop; other site 1091494008028 ATP binding site [chemical binding]; other site 1091494008029 Q-loop/lid; other site 1091494008030 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1091494008031 ABC transporter signature motif; other site 1091494008032 Walker B; other site 1091494008033 D-loop; other site 1091494008034 H-loop/switch region; other site 1091494008035 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1091494008036 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1091494008037 active site 1091494008038 metal binding site [ion binding]; metal-binding site 1091494008039 DNA binding site [nucleotide binding] 1091494008040 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1091494008041 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494008042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008043 active site 1091494008044 phosphorylation site [posttranslational modification] 1091494008045 intermolecular recognition site; other site 1091494008046 dimerization interface [polypeptide binding]; other site 1091494008047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494008048 Zn2+ binding site [ion binding]; other site 1091494008049 Mg2+ binding site [ion binding]; other site 1091494008050 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008052 active site 1091494008053 phosphorylation site [posttranslational modification] 1091494008054 intermolecular recognition site; other site 1091494008055 dimerization interface [polypeptide binding]; other site 1091494008056 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1091494008057 active site 1091494008058 tetramer interface; other site 1091494008059 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1091494008060 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1091494008061 Substrate binding site; other site 1091494008062 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1091494008063 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1091494008064 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1091494008065 ligand-binding site [chemical binding]; other site 1091494008066 UDP-glucose 4-epimerase; Region: PLN02240 1091494008067 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1091494008068 NAD binding site [chemical binding]; other site 1091494008069 homodimer interface [polypeptide binding]; other site 1091494008070 active site 1091494008071 substrate binding site [chemical binding]; other site 1091494008072 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 1091494008073 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1091494008074 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494008075 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1091494008076 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1091494008077 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1091494008078 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091494008079 MgtE intracellular N domain; Region: MgtE_N; smart00924 1091494008080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091494008081 Divalent cation transporter; Region: MgtE; pfam01769 1091494008082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494008083 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1091494008084 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1091494008085 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1091494008086 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1091494008087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1091494008088 catalytic residue [active] 1091494008089 Transcriptional regulator; Region: Rrf2; cl17282 1091494008090 Rrf2 family protein; Region: rrf2_super; TIGR00738 1091494008091 serine O-acetyltransferase; Region: cysE; TIGR01172 1091494008092 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1091494008093 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1091494008094 trimer interface [polypeptide binding]; other site 1091494008095 active site 1091494008096 substrate binding site [chemical binding]; other site 1091494008097 CoA binding site [chemical binding]; other site 1091494008098 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1091494008099 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1091494008100 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091494008101 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1091494008102 active site 1091494008103 dimerization interface [polypeptide binding]; other site 1091494008104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494008105 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1091494008106 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1091494008107 dimer interface [polypeptide binding]; other site 1091494008108 active site residues [active] 1091494008109 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1091494008110 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1091494008111 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1091494008112 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1091494008113 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494008114 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1091494008115 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1091494008116 putative catalytic site [active] 1091494008117 putative metal binding site [ion binding]; other site 1091494008118 putative phosphate binding site [ion binding]; other site 1091494008119 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1091494008120 nudix motif; other site 1091494008121 elongation factor P; Provisional; Region: PRK04542 1091494008122 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1091494008123 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1091494008124 RNA binding site [nucleotide binding]; other site 1091494008125 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1091494008126 RNA binding site [nucleotide binding]; other site 1091494008127 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1091494008128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494008129 ATP binding site [chemical binding]; other site 1091494008130 putative Mg++ binding site [ion binding]; other site 1091494008131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494008132 nucleotide binding region [chemical binding]; other site 1091494008133 ATP-binding site [chemical binding]; other site 1091494008134 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1091494008135 HRDC domain; Region: HRDC; pfam00570 1091494008136 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1091494008137 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1091494008138 Active Sites [active] 1091494008139 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1091494008140 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1091494008141 dimerization interface [polypeptide binding]; other site 1091494008142 domain crossover interface; other site 1091494008143 redox-dependent activation switch; other site 1091494008144 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1091494008145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494008146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1091494008147 dimer interface [polypeptide binding]; other site 1091494008148 phosphorylation site [posttranslational modification] 1091494008149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008150 ATP binding site [chemical binding]; other site 1091494008151 Mg2+ binding site [ion binding]; other site 1091494008152 G-X-G motif; other site 1091494008153 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1091494008154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008155 active site 1091494008156 phosphorylation site [posttranslational modification] 1091494008157 intermolecular recognition site; other site 1091494008158 dimerization interface [polypeptide binding]; other site 1091494008159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494008160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1091494008161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1091494008162 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1091494008163 hypothetical protein; Validated; Region: PRK08223 1091494008164 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1091494008165 ATP binding site [chemical binding]; other site 1091494008166 substrate interface [chemical binding]; other site 1091494008167 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1091494008168 hydrolase; Region: PLN02578 1091494008169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494008170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008171 TPR motif; other site 1091494008172 TPR repeat; Region: TPR_11; pfam13414 1091494008173 binding surface 1091494008174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494008175 TPR motif; other site 1091494008176 binding surface 1091494008177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008178 TPR motif; other site 1091494008179 binding surface 1091494008180 TPR repeat; Region: TPR_11; pfam13414 1091494008181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008182 binding surface 1091494008183 TPR motif; other site 1091494008184 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494008185 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1091494008186 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1091494008187 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494008188 Putative addiction module component; Region: Unstab_antitox; pfam09720 1091494008189 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1091494008190 putative active site [active] 1091494008191 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1091494008192 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1091494008193 Protein of unknown function DUF86; Region: DUF86; cl01031 1091494008194 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1091494008195 active site 1091494008196 NTP binding site [chemical binding]; other site 1091494008197 metal binding triad [ion binding]; metal-binding site 1091494008198 antibiotic binding site [chemical binding]; other site 1091494008199 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494008200 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1091494008201 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 1091494008202 active site 1091494008203 catalytic triad [active] 1091494008204 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1091494008205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008206 binding surface 1091494008207 TPR motif; other site 1091494008208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008209 binding surface 1091494008210 TPR motif; other site 1091494008211 TPR repeat; Region: TPR_11; pfam13414 1091494008212 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1091494008213 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 1091494008214 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1091494008215 AMIN domain; Region: AMIN; pfam11741 1091494008216 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1091494008217 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1091494008218 active site 1091494008219 homodimer interface [polypeptide binding]; other site 1091494008220 exonuclease subunit SbcC; Provisional; Region: PRK10246 1091494008221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494008222 Walker A/P-loop; other site 1091494008223 ATP binding site [chemical binding]; other site 1091494008224 Q-loop/lid; other site 1091494008225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494008226 ABC transporter signature motif; other site 1091494008227 Walker B; other site 1091494008228 D-loop; other site 1091494008229 H-loop/switch region; other site 1091494008230 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1091494008231 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1091494008232 putative acyl-acceptor binding pocket; other site 1091494008233 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1091494008234 acyl-activating enzyme (AAE) consensus motif; other site 1091494008235 putative AMP binding site [chemical binding]; other site 1091494008236 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1091494008237 polyphosphate kinase; Provisional; Region: PRK05443 1091494008238 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1091494008239 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1091494008240 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1091494008241 putative domain interface [polypeptide binding]; other site 1091494008242 putative active site [active] 1091494008243 catalytic site [active] 1091494008244 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1091494008245 putative domain interface [polypeptide binding]; other site 1091494008246 putative active site [active] 1091494008247 catalytic site [active] 1091494008248 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1091494008249 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1091494008250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494008251 putative Mg++ binding site [ion binding]; other site 1091494008252 Double zinc ribbon; Region: DZR; pfam12773 1091494008253 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 1091494008254 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1091494008255 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1091494008256 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494008257 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494008258 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494008259 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1091494008260 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1091494008261 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1091494008262 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1091494008263 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1091494008264 Helix-turn-helix domain; Region: HTH_17; pfam12728 1091494008265 carbon storage regulator; Provisional; Region: PRK01712 1091494008266 aspartate kinase; Reviewed; Region: PRK06635 1091494008267 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1091494008268 putative nucleotide binding site [chemical binding]; other site 1091494008269 putative catalytic residues [active] 1091494008270 putative Mg ion binding site [ion binding]; other site 1091494008271 putative aspartate binding site [chemical binding]; other site 1091494008272 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1091494008273 putative allosteric regulatory site; other site 1091494008274 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1091494008275 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1091494008276 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1091494008277 motif 1; other site 1091494008278 active site 1091494008279 motif 2; other site 1091494008280 motif 3; other site 1091494008281 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1091494008282 DHHA1 domain; Region: DHHA1; pfam02272 1091494008283 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1091494008284 recombinase A; Provisional; Region: recA; PRK09354 1091494008285 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1091494008286 hexamer interface [polypeptide binding]; other site 1091494008287 Walker A motif; other site 1091494008288 ATP binding site [chemical binding]; other site 1091494008289 Walker B motif; other site 1091494008290 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1091494008291 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1091494008292 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1091494008293 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1091494008294 inhibitor-cofactor binding pocket; inhibition site 1091494008295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494008296 catalytic residue [active] 1091494008297 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1091494008298 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1091494008299 putative phosphoketolase; Provisional; Region: PRK05261 1091494008300 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1091494008301 TPP-binding site; other site 1091494008302 XFP C-terminal domain; Region: XFP_C; pfam09363 1091494008303 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1091494008304 propionate/acetate kinase; Provisional; Region: PRK12379 1091494008305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1091494008306 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1091494008307 putative NAD(P) binding site [chemical binding]; other site 1091494008308 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1091494008309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1091494008310 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1091494008311 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1091494008312 active site 1091494008313 homodimer interface [polypeptide binding]; other site 1091494008314 catalytic site [active] 1091494008315 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1091494008316 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1091494008317 AMP binding site [chemical binding]; other site 1091494008318 metal binding site [ion binding]; metal-binding site 1091494008319 active site 1091494008320 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1091494008321 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091494008322 catalytic triad [active] 1091494008323 hypothetical protein; Provisional; Region: PRK08960 1091494008324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1091494008325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494008326 homodimer interface [polypeptide binding]; other site 1091494008327 catalytic residue [active] 1091494008328 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1091494008329 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1091494008330 KMSKS motif; other site 1091494008331 acetyl-CoA synthetase; Provisional; Region: PRK00174 1091494008332 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1091494008333 active site 1091494008334 CoA binding site [chemical binding]; other site 1091494008335 acyl-activating enzyme (AAE) consensus motif; other site 1091494008336 AMP binding site [chemical binding]; other site 1091494008337 acetate binding site [chemical binding]; other site 1091494008338 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1091494008339 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1091494008340 Active Sites [active] 1091494008341 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1091494008342 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1091494008343 CysD dimerization site [polypeptide binding]; other site 1091494008344 G1 box; other site 1091494008345 putative GEF interaction site [polypeptide binding]; other site 1091494008346 GTP/Mg2+ binding site [chemical binding]; other site 1091494008347 Switch I region; other site 1091494008348 G2 box; other site 1091494008349 G3 box; other site 1091494008350 Switch II region; other site 1091494008351 G4 box; other site 1091494008352 G5 box; other site 1091494008353 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1091494008354 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1091494008355 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1091494008356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494008357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494008358 metal binding site [ion binding]; metal-binding site 1091494008359 active site 1091494008360 I-site; other site 1091494008361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494008362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008363 active site 1091494008364 phosphorylation site [posttranslational modification] 1091494008365 intermolecular recognition site; other site 1091494008366 dimerization interface [polypeptide binding]; other site 1091494008367 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1091494008368 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494008369 putative binding surface; other site 1091494008370 active site 1091494008371 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1091494008372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008373 ATP binding site [chemical binding]; other site 1091494008374 Mg2+ binding site [ion binding]; other site 1091494008375 G-X-G motif; other site 1091494008376 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1091494008377 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1091494008378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008379 PAS domain; Region: PAS_9; pfam13426 1091494008380 putative active site [active] 1091494008381 heme pocket [chemical binding]; other site 1091494008382 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494008383 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494008384 dimer interface [polypeptide binding]; other site 1091494008385 putative CheW interface [polypeptide binding]; other site 1091494008386 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1091494008387 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1091494008388 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494008389 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1091494008390 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494008391 CheD chemotactic sensory transduction; Region: CheD; cl00810 1091494008392 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1091494008393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008394 active site 1091494008395 phosphorylation site [posttranslational modification] 1091494008396 intermolecular recognition site; other site 1091494008397 dimerization interface [polypeptide binding]; other site 1091494008398 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494008399 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494008400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494008401 dimer interface [polypeptide binding]; other site 1091494008402 putative CheW interface [polypeptide binding]; other site 1091494008403 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091494008404 anti sigma factor interaction site; other site 1091494008405 regulatory phosphorylation site [posttranslational modification]; other site 1091494008406 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1091494008407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1091494008408 ATP binding site [chemical binding]; other site 1091494008409 Mg2+ binding site [ion binding]; other site 1091494008410 G-X-G motif; other site 1091494008411 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1091494008412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1091494008413 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494008414 putative binding surface; other site 1091494008415 active site 1091494008416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008417 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008418 active site 1091494008419 phosphorylation site [posttranslational modification] 1091494008420 intermolecular recognition site; other site 1091494008421 dimerization interface [polypeptide binding]; other site 1091494008422 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008424 active site 1091494008425 phosphorylation site [posttranslational modification] 1091494008426 intermolecular recognition site; other site 1091494008427 dimerization interface [polypeptide binding]; other site 1091494008428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008429 PAS domain; Region: PAS_9; pfam13426 1091494008430 putative active site [active] 1091494008431 heme pocket [chemical binding]; other site 1091494008432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008433 PAS domain; Region: PAS_9; pfam13426 1091494008434 putative active site [active] 1091494008435 heme pocket [chemical binding]; other site 1091494008436 PAS fold; Region: PAS_7; pfam12860 1091494008437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008438 PAS fold; Region: PAS_3; pfam08447 1091494008439 putative active site [active] 1091494008440 heme pocket [chemical binding]; other site 1091494008441 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494008442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008443 putative active site [active] 1091494008444 heme pocket [chemical binding]; other site 1091494008445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008446 dimer interface [polypeptide binding]; other site 1091494008447 phosphorylation site [posttranslational modification] 1091494008448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008449 ATP binding site [chemical binding]; other site 1091494008450 Mg2+ binding site [ion binding]; other site 1091494008451 G-X-G motif; other site 1091494008452 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008454 active site 1091494008455 phosphorylation site [posttranslational modification] 1091494008456 intermolecular recognition site; other site 1091494008457 dimerization interface [polypeptide binding]; other site 1091494008458 PAS fold; Region: PAS_3; pfam08447 1091494008459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008460 putative active site [active] 1091494008461 heme pocket [chemical binding]; other site 1091494008462 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494008463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008464 putative active site [active] 1091494008465 heme pocket [chemical binding]; other site 1091494008466 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494008467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008468 putative active site [active] 1091494008469 heme pocket [chemical binding]; other site 1091494008470 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494008471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008472 putative active site [active] 1091494008473 heme pocket [chemical binding]; other site 1091494008474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008475 dimer interface [polypeptide binding]; other site 1091494008476 phosphorylation site [posttranslational modification] 1091494008477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008478 ATP binding site [chemical binding]; other site 1091494008479 Mg2+ binding site [ion binding]; other site 1091494008480 G-X-G motif; other site 1091494008481 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008483 active site 1091494008484 phosphorylation site [posttranslational modification] 1091494008485 intermolecular recognition site; other site 1091494008486 dimerization interface [polypeptide binding]; other site 1091494008487 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1091494008488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008489 active site 1091494008490 phosphorylation site [posttranslational modification] 1091494008491 intermolecular recognition site; other site 1091494008492 dimerization interface [polypeptide binding]; other site 1091494008493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494008494 Zn2+ binding site [ion binding]; other site 1091494008495 Mg2+ binding site [ion binding]; other site 1091494008496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494008497 GAF domain; Region: GAF; pfam01590 1091494008498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008499 PAS domain; Region: PAS_9; pfam13426 1091494008500 putative active site [active] 1091494008501 heme pocket [chemical binding]; other site 1091494008502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008503 putative active site [active] 1091494008504 PAS fold; Region: PAS_3; pfam08447 1091494008505 heme pocket [chemical binding]; other site 1091494008506 PAS domain S-box; Region: sensory_box; TIGR00229 1091494008507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008508 putative active site [active] 1091494008509 heme pocket [chemical binding]; other site 1091494008510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494008512 dimer interface [polypeptide binding]; other site 1091494008513 phosphorylation site [posttranslational modification] 1091494008514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008515 ATP binding site [chemical binding]; other site 1091494008516 Mg2+ binding site [ion binding]; other site 1091494008517 G-X-G motif; other site 1091494008518 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1091494008519 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1091494008520 HAMP domain; Region: HAMP; pfam00672 1091494008521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008522 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494008523 putative active site [active] 1091494008524 heme pocket [chemical binding]; other site 1091494008525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008526 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1091494008527 putative active site [active] 1091494008528 heme pocket [chemical binding]; other site 1091494008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008530 putative active site [active] 1091494008531 heme pocket [chemical binding]; other site 1091494008532 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494008533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008534 putative active site [active] 1091494008535 heme pocket [chemical binding]; other site 1091494008536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008537 phosphorylation site [posttranslational modification] 1091494008538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008539 ATP binding site [chemical binding]; other site 1091494008540 Mg2+ binding site [ion binding]; other site 1091494008541 G-X-G motif; other site 1091494008542 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008544 active site 1091494008545 phosphorylation site [posttranslational modification] 1091494008546 intermolecular recognition site; other site 1091494008547 dimerization interface [polypeptide binding]; other site 1091494008548 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494008549 putative binding surface; other site 1091494008550 active site 1091494008551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008552 active site 1091494008553 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1091494008554 phosphorylation site [posttranslational modification] 1091494008555 intermolecular recognition site; other site 1091494008556 dimerization interface [polypeptide binding]; other site 1091494008557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008558 active site 1091494008559 phosphorylation site [posttranslational modification] 1091494008560 intermolecular recognition site; other site 1091494008561 dimerization interface [polypeptide binding]; other site 1091494008562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494008563 metal binding site [ion binding]; metal-binding site 1091494008564 active site 1091494008565 I-site; other site 1091494008566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494008567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494008568 WHG domain; Region: WHG; pfam13305 1091494008569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091494008570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494008571 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1091494008572 putative effector binding pocket; other site 1091494008573 dimerization interface [polypeptide binding]; other site 1091494008574 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1091494008575 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1091494008576 nudix motif; other site 1091494008577 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1091494008578 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1091494008579 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494008580 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1091494008581 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1091494008582 TrkA-C domain; Region: TrkA_C; pfam02080 1091494008583 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1091494008584 TrkA-C domain; Region: TrkA_C; pfam02080 1091494008585 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1091494008586 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1091494008587 MarR family; Region: MarR_2; pfam12802 1091494008588 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 1091494008589 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1091494008590 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1091494008591 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1091494008592 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1091494008593 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1091494008594 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1091494008595 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091494008596 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1091494008597 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1091494008598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008599 ATP binding site [chemical binding]; other site 1091494008600 Mg2+ binding site [ion binding]; other site 1091494008601 G-X-G motif; other site 1091494008602 PAS fold; Region: PAS_3; pfam08447 1091494008603 PAS fold; Region: PAS_4; pfam08448 1091494008604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008605 dimer interface [polypeptide binding]; other site 1091494008606 phosphorylation site [posttranslational modification] 1091494008607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008608 ATP binding site [chemical binding]; other site 1091494008609 Mg2+ binding site [ion binding]; other site 1091494008610 G-X-G motif; other site 1091494008611 CHASE domain; Region: CHASE; pfam03924 1091494008612 PAS domain S-box; Region: sensory_box; TIGR00229 1091494008613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494008614 putative active site [active] 1091494008615 heme pocket [chemical binding]; other site 1091494008616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008617 dimer interface [polypeptide binding]; other site 1091494008618 phosphorylation site [posttranslational modification] 1091494008619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008620 ATP binding site [chemical binding]; other site 1091494008621 Mg2+ binding site [ion binding]; other site 1091494008622 G-X-G motif; other site 1091494008623 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1091494008624 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1091494008625 HEAT repeats; Region: HEAT_2; pfam13646 1091494008626 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1091494008627 tetramer interfaces [polypeptide binding]; other site 1091494008628 binuclear metal-binding site [ion binding]; other site 1091494008629 thiamine monophosphate kinase; Provisional; Region: PRK05731 1091494008630 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1091494008631 ATP binding site [chemical binding]; other site 1091494008632 dimerization interface [polypeptide binding]; other site 1091494008633 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1091494008634 putative RNA binding site [nucleotide binding]; other site 1091494008635 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1091494008636 homopentamer interface [polypeptide binding]; other site 1091494008637 active site 1091494008638 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1091494008639 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1091494008640 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1091494008641 dimerization interface [polypeptide binding]; other site 1091494008642 active site 1091494008643 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1091494008644 Lumazine binding domain; Region: Lum_binding; pfam00677 1091494008645 Lumazine binding domain; Region: Lum_binding; pfam00677 1091494008646 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1091494008647 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1091494008648 catalytic motif [active] 1091494008649 Zn binding site [ion binding]; other site 1091494008650 RibD C-terminal domain; Region: RibD_C; cl17279 1091494008651 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1091494008652 ATP cone domain; Region: ATP-cone; pfam03477 1091494008653 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1091494008654 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1091494008655 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1091494008656 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1091494008657 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1091494008658 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1091494008659 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1091494008660 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1091494008661 general secretion pathway protein J; Validated; Region: PRK08808 1091494008662 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1091494008663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1091494008664 type II secretion system protein I; Region: gspI; TIGR01707 1091494008665 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1091494008666 Type II transport protein GspH; Region: GspH; pfam12019 1091494008667 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1091494008668 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1091494008669 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1091494008670 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1091494008671 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494008672 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494008673 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1091494008674 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1091494008675 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1091494008676 Walker A motif; other site 1091494008677 ATP binding site [chemical binding]; other site 1091494008678 Walker B motif; other site 1091494008679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494008680 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 1091494008681 putative ADP-binding pocket [chemical binding]; other site 1091494008682 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1091494008683 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1091494008684 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 1091494008685 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1091494008686 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1091494008687 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1091494008688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494008689 dimerization interface [polypeptide binding]; other site 1091494008690 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494008691 dimer interface [polypeptide binding]; other site 1091494008692 putative CheW interface [polypeptide binding]; other site 1091494008693 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1091494008694 putative CheA interaction surface; other site 1091494008695 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1091494008696 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494008697 putative binding surface; other site 1091494008698 active site 1091494008699 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1091494008700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008701 ATP binding site [chemical binding]; other site 1091494008702 Mg2+ binding site [ion binding]; other site 1091494008703 G-X-G motif; other site 1091494008704 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1091494008705 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1091494008706 anti sigma factor interaction site; other site 1091494008707 regulatory phosphorylation site [posttranslational modification]; other site 1091494008708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1091494008709 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1091494008710 AAA domain; Region: AAA_33; pfam13671 1091494008711 ATP-binding site [chemical binding]; other site 1091494008712 Gluconate-6-phosphate binding site [chemical binding]; other site 1091494008713 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1091494008714 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1091494008715 active site 1091494008716 Peptidase family M48; Region: Peptidase_M48; cl12018 1091494008717 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494008718 metal ion-dependent adhesion site (MIDAS); other site 1091494008719 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1091494008720 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1091494008721 active site 1091494008722 ATP binding site [chemical binding]; other site 1091494008723 substrate binding site [chemical binding]; other site 1091494008724 activation loop (A-loop); other site 1091494008725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494008726 phosphopeptide binding site; other site 1091494008727 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1091494008728 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1091494008729 phosphopeptide binding site; other site 1091494008730 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1091494008731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091494008732 Walker A/P-loop; other site 1091494008733 ATP binding site [chemical binding]; other site 1091494008734 Q-loop/lid; other site 1091494008735 ABC transporter signature motif; other site 1091494008736 Walker B; other site 1091494008737 D-loop; other site 1091494008738 H-loop/switch region; other site 1091494008739 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1091494008740 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1091494008741 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494008742 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1091494008743 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494008744 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1091494008745 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1091494008746 dimerization domain [polypeptide binding]; other site 1091494008747 dimer interface [polypeptide binding]; other site 1091494008748 catalytic residues [active] 1091494008749 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1091494008750 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1091494008751 active site 1091494008752 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1091494008753 protein binding site [polypeptide binding]; other site 1091494008754 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1091494008755 putative substrate binding region [chemical binding]; other site 1091494008756 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1091494008757 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1091494008758 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1091494008759 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1091494008760 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1091494008761 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1091494008762 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1091494008763 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1091494008764 catalytic residue [active] 1091494008765 putative FPP diphosphate binding site; other site 1091494008766 putative FPP binding hydrophobic cleft; other site 1091494008767 dimer interface [polypeptide binding]; other site 1091494008768 putative IPP diphosphate binding site; other site 1091494008769 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1091494008770 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1091494008771 hinge region; other site 1091494008772 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1091494008773 putative nucleotide binding site [chemical binding]; other site 1091494008774 uridine monophosphate binding site [chemical binding]; other site 1091494008775 homohexameric interface [polypeptide binding]; other site 1091494008776 elongation factor Ts; Provisional; Region: tsf; PRK09377 1091494008777 UBA/TS-N domain; Region: UBA; pfam00627 1091494008778 Elongation factor TS; Region: EF_TS; pfam00889 1091494008779 Elongation factor TS; Region: EF_TS; pfam00889 1091494008780 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1091494008781 rRNA interaction site [nucleotide binding]; other site 1091494008782 S8 interaction site; other site 1091494008783 putative laminin-1 binding site; other site 1091494008784 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1091494008785 active site 1091494008786 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1091494008787 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1091494008788 metal binding triad; other site 1091494008789 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1091494008790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494008791 Zn2+ binding site [ion binding]; other site 1091494008792 Mg2+ binding site [ion binding]; other site 1091494008793 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1091494008794 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1091494008795 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1091494008796 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494008797 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091494008798 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1091494008799 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1091494008800 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1091494008801 active site 1091494008802 dimer interface [polypeptide binding]; other site 1091494008803 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1091494008804 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1091494008805 active site 1091494008806 FMN binding site [chemical binding]; other site 1091494008807 substrate binding site [chemical binding]; other site 1091494008808 3Fe-4S cluster binding site [ion binding]; other site 1091494008809 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1091494008810 domain_subunit interface; other site 1091494008811 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1091494008812 Flavodoxin; Region: Flavodoxin_1; pfam00258 1091494008813 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1091494008814 FAD binding pocket [chemical binding]; other site 1091494008815 FAD binding motif [chemical binding]; other site 1091494008816 catalytic residues [active] 1091494008817 NAD binding pocket [chemical binding]; other site 1091494008818 phosphate binding motif [ion binding]; other site 1091494008819 beta-alpha-beta structure motif; other site 1091494008820 ATP-dependent helicase HepA; Validated; Region: PRK04914 1091494008821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494008822 ATP binding site [chemical binding]; other site 1091494008823 putative Mg++ binding site [ion binding]; other site 1091494008824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494008825 nucleotide binding region [chemical binding]; other site 1091494008826 ATP-binding site [chemical binding]; other site 1091494008827 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1091494008828 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1091494008829 motif 1; other site 1091494008830 dimer interface [polypeptide binding]; other site 1091494008831 active site 1091494008832 motif 2; other site 1091494008833 motif 3; other site 1091494008834 elongation factor P; Validated; Region: PRK00529 1091494008835 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1091494008836 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1091494008837 RNA binding site [nucleotide binding]; other site 1091494008838 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1091494008839 RNA binding site [nucleotide binding]; other site 1091494008840 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1091494008841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1091494008842 FeS/SAM binding site; other site 1091494008843 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1091494008844 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1091494008845 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 1091494008846 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1091494008847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494008848 putative substrate translocation pore; other site 1091494008849 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1091494008850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008851 binding surface 1091494008852 TPR motif; other site 1091494008853 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494008854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008855 TPR motif; other site 1091494008856 binding surface 1091494008857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008858 binding surface 1091494008859 TPR motif; other site 1091494008860 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494008861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008862 binding surface 1091494008863 TPR motif; other site 1091494008864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008865 TPR motif; other site 1091494008866 binding surface 1091494008867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008868 binding surface 1091494008869 TPR motif; other site 1091494008870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494008871 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494008872 binding surface 1091494008873 TPR motif; other site 1091494008874 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1091494008875 TonB C terminal; Region: TonB_2; pfam13103 1091494008876 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494008877 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1091494008878 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1091494008879 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1091494008880 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1091494008881 PBP superfamily domain; Region: PBP_like_2; cl17296 1091494008882 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1091494008883 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1091494008884 Surface antigen; Region: Bac_surface_Ag; pfam01103 1091494008885 haemagglutination activity domain; Region: Haemagg_act; smart00912 1091494008886 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1091494008887 polycystin cation channel protein; Region: PCC; TIGR00864 1091494008888 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1091494008889 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1091494008890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494008891 dimer interface [polypeptide binding]; other site 1091494008892 phosphorylation site [posttranslational modification] 1091494008893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494008894 ATP binding site [chemical binding]; other site 1091494008895 Mg2+ binding site [ion binding]; other site 1091494008896 G-X-G motif; other site 1091494008897 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1091494008898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494008899 active site 1091494008900 phosphorylation site [posttranslational modification] 1091494008901 intermolecular recognition site; other site 1091494008902 dimerization interface [polypeptide binding]; other site 1091494008903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494008904 DNA binding site [nucleotide binding] 1091494008905 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1091494008906 Amidohydrolase; Region: Amidohydro_2; pfam04909 1091494008907 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1091494008908 Clp amino terminal domain; Region: Clp_N; pfam02861 1091494008909 Clp amino terminal domain; Region: Clp_N; pfam02861 1091494008910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494008911 Walker A motif; other site 1091494008912 ATP binding site [chemical binding]; other site 1091494008913 Walker B motif; other site 1091494008914 arginine finger; other site 1091494008915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494008916 Walker A motif; other site 1091494008917 ATP binding site [chemical binding]; other site 1091494008918 Walker B motif; other site 1091494008919 arginine finger; other site 1091494008920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1091494008921 Autotransporter beta-domain; Region: Autotransporter; smart00869 1091494008922 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1091494008923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494008924 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494008925 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494008926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1091494008927 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494008928 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1091494008929 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1091494008930 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 1091494008931 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1091494008932 FOG: CBS domain [General function prediction only]; Region: COG0517 1091494008933 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 1091494008934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1091494008935 DNA-binding site [nucleotide binding]; DNA binding site 1091494008936 RNA-binding motif; other site 1091494008937 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1091494008938 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1091494008939 Kelch motif; Region: Kelch_1; pfam01344 1091494008940 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1091494008941 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1091494008942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1091494008943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494008944 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1091494008945 DNA-binding site [nucleotide binding]; DNA binding site 1091494008946 RNA-binding motif; other site 1091494008947 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1091494008948 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1091494008949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091494008950 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494008951 Walker A/P-loop; other site 1091494008952 ATP binding site [chemical binding]; other site 1091494008953 Q-loop/lid; other site 1091494008954 ABC transporter signature motif; other site 1091494008955 Walker B; other site 1091494008956 D-loop; other site 1091494008957 H-loop/switch region; other site 1091494008958 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1091494008959 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494008960 FtsX-like permease family; Region: FtsX; pfam02687 1091494008961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494008962 binding surface 1091494008963 TPR motif; other site 1091494008964 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1091494008965 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1091494008966 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494008967 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1091494008968 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494008969 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1091494008970 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1091494008971 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1091494008972 Family description; Region: DsbD_2; pfam13386 1091494008973 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1091494008974 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1091494008975 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1091494008976 dimer interface [polypeptide binding]; other site 1091494008977 active site 1091494008978 citrylCoA binding site [chemical binding]; other site 1091494008979 NADH binding [chemical binding]; other site 1091494008980 cationic pore residues; other site 1091494008981 oxalacetate/citrate binding site [chemical binding]; other site 1091494008982 coenzyme A binding site [chemical binding]; other site 1091494008983 catalytic triad [active] 1091494008984 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1091494008985 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1091494008986 substrate binding site [chemical binding]; other site 1091494008987 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1091494008988 substrate binding site [chemical binding]; other site 1091494008989 ligand binding site [chemical binding]; other site 1091494008990 tartrate dehydrogenase; Region: TTC; TIGR02089 1091494008991 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1091494008992 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494008993 putative active site [active] 1091494008994 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1091494008995 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1091494008996 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1091494008997 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091494008998 ATP binding site [chemical binding]; other site 1091494008999 Mg++ binding site [ion binding]; other site 1091494009000 motif III; other site 1091494009001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494009002 nucleotide binding region [chemical binding]; other site 1091494009003 ATP-binding site [chemical binding]; other site 1091494009004 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1091494009005 putative RNA binding site [nucleotide binding]; other site 1091494009006 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1091494009007 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1091494009008 active site 1091494009009 catalytic site [active] 1091494009010 substrate binding site [chemical binding]; other site 1091494009011 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1091494009012 putative hydrolase; Provisional; Region: PRK11460 1091494009013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1091494009014 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1091494009015 MASE1; Region: MASE1; cl17823 1091494009016 CHASE domain; Region: CHASE; pfam03924 1091494009017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494009018 PAS domain; Region: PAS_9; pfam13426 1091494009019 putative active site [active] 1091494009020 heme pocket [chemical binding]; other site 1091494009021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494009022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494009023 metal binding site [ion binding]; metal-binding site 1091494009024 active site 1091494009025 I-site; other site 1091494009026 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494009027 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1091494009028 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091494009029 active site 1091494009030 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1091494009031 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494009032 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494009033 catalytic residue [active] 1091494009034 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494009035 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1091494009036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494009037 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1091494009038 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494009039 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1091494009040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091494009041 Walker A/P-loop; other site 1091494009042 ATP binding site [chemical binding]; other site 1091494009043 Q-loop/lid; other site 1091494009044 ABC transporter signature motif; other site 1091494009045 Walker B; other site 1091494009046 D-loop; other site 1091494009047 H-loop/switch region; other site 1091494009048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091494009049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091494009050 Walker A/P-loop; other site 1091494009051 ATP binding site [chemical binding]; other site 1091494009052 Q-loop/lid; other site 1091494009053 ABC transporter signature motif; other site 1091494009054 Walker B; other site 1091494009055 D-loop; other site 1091494009056 H-loop/switch region; other site 1091494009057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091494009058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1091494009059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494009060 dimer interface [polypeptide binding]; other site 1091494009061 conserved gate region; other site 1091494009062 putative PBP binding loops; other site 1091494009063 ABC-ATPase subunit interface; other site 1091494009064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091494009065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494009066 dimer interface [polypeptide binding]; other site 1091494009067 conserved gate region; other site 1091494009068 putative PBP binding loops; other site 1091494009069 ABC-ATPase subunit interface; other site 1091494009070 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 1091494009071 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1091494009072 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1091494009073 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1091494009074 NAD binding site [chemical binding]; other site 1091494009075 homotetramer interface [polypeptide binding]; other site 1091494009076 homodimer interface [polypeptide binding]; other site 1091494009077 substrate binding site [chemical binding]; other site 1091494009078 active site 1091494009079 periplasmic folding chaperone; Provisional; Region: PRK10788 1091494009080 SurA N-terminal domain; Region: SurA_N_3; cl07813 1091494009081 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1091494009082 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1091494009083 IHF dimer interface [polypeptide binding]; other site 1091494009084 IHF - DNA interface [nucleotide binding]; other site 1091494009085 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1091494009086 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1091494009087 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1091494009088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494009089 Walker A motif; other site 1091494009090 ATP binding site [chemical binding]; other site 1091494009091 Walker B motif; other site 1091494009092 arginine finger; other site 1091494009093 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1091494009094 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1091494009095 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1091494009096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494009097 Walker A motif; other site 1091494009098 ATP binding site [chemical binding]; other site 1091494009099 Walker B motif; other site 1091494009100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1091494009101 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1091494009102 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1091494009103 oligomer interface [polypeptide binding]; other site 1091494009104 active site residues [active] 1091494009105 trigger factor; Provisional; Region: tig; PRK01490 1091494009106 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091494009107 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1091494009108 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1091494009109 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1091494009110 GAF domain; Region: GAF; pfam01590 1091494009111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494009112 Walker B motif; other site 1091494009113 arginine finger; other site 1091494009114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494009115 putative substrate translocation pore; other site 1091494009116 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1091494009117 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1091494009118 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1091494009119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494009120 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494009121 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1091494009122 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1091494009123 GDP-binding site [chemical binding]; other site 1091494009124 ACT binding site; other site 1091494009125 IMP binding site; other site 1091494009126 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1091494009127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1091494009128 dimer interface [polypeptide binding]; other site 1091494009129 motif 1; other site 1091494009130 active site 1091494009131 motif 2; other site 1091494009132 motif 3; other site 1091494009133 FtsH protease regulator HflC; Provisional; Region: PRK11029 1091494009134 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1091494009135 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1091494009136 HflK protein; Region: hflK; TIGR01933 1091494009137 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1091494009138 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1091494009139 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1091494009140 HflX GTPase family; Region: HflX; cd01878 1091494009141 G1 box; other site 1091494009142 GTP/Mg2+ binding site [chemical binding]; other site 1091494009143 Switch I region; other site 1091494009144 G2 box; other site 1091494009145 G3 box; other site 1091494009146 Switch II region; other site 1091494009147 G4 box; other site 1091494009148 G5 box; other site 1091494009149 bacterial Hfq-like; Region: Hfq; cd01716 1091494009150 hexamer interface [polypeptide binding]; other site 1091494009151 Sm1 motif; other site 1091494009152 RNA binding site [nucleotide binding]; other site 1091494009153 Sm2 motif; other site 1091494009154 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494009155 acyl-CoA esterase; Provisional; Region: PRK10673 1091494009156 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1091494009157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1091494009158 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1091494009159 HI0933-like protein; Region: HI0933_like; pfam03486 1091494009160 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1091494009161 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1091494009162 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1091494009163 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494009164 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1091494009165 HemY protein N-terminus; Region: HemY_N; pfam07219 1091494009166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494009167 binding surface 1091494009168 TPR motif; other site 1091494009169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494009170 binding surface 1091494009171 TPR motif; other site 1091494009172 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1091494009173 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1091494009174 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1091494009175 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1091494009176 active site 1091494009177 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1091494009178 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1091494009179 domain interfaces; other site 1091494009180 active site 1091494009181 argininosuccinate lyase; Provisional; Region: PRK00855 1091494009182 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1091494009183 active sites [active] 1091494009184 tetramer interface [polypeptide binding]; other site 1091494009185 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1091494009186 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1091494009187 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1091494009188 PilZ domain; Region: PilZ; pfam07238 1091494009189 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1091494009190 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1091494009191 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1091494009192 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1091494009193 pyruvate kinase; Provisional; Region: PRK05826 1091494009194 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1091494009195 domain interfaces; other site 1091494009196 active site 1091494009197 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1091494009198 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1091494009199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494009200 PAS domain; Region: PAS_9; pfam13426 1091494009201 putative active site [active] 1091494009202 heme pocket [chemical binding]; other site 1091494009203 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1091494009204 hydrophobic ligand binding site; other site 1091494009205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494009206 PAS domain; Region: PAS_9; pfam13426 1091494009207 putative active site [active] 1091494009208 heme pocket [chemical binding]; other site 1091494009209 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1091494009210 hydrophobic ligand binding site; other site 1091494009211 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1091494009212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494009213 Mg2+ binding site [ion binding]; other site 1091494009214 G-X-G motif; other site 1091494009215 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1091494009216 anchoring element; other site 1091494009217 dimer interface [polypeptide binding]; other site 1091494009218 ATP binding site [chemical binding]; other site 1091494009219 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1091494009220 active site 1091494009221 metal binding site [ion binding]; metal-binding site 1091494009222 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1091494009223 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1091494009224 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091494009225 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091494009226 substrate binding pocket [chemical binding]; other site 1091494009227 chain length determination region; other site 1091494009228 substrate-Mg2+ binding site; other site 1091494009229 catalytic residues [active] 1091494009230 aspartate-rich region 1; other site 1091494009231 active site lid residues [active] 1091494009232 aspartate-rich region 2; other site 1091494009233 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1091494009234 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1091494009235 TPP-binding site; other site 1091494009236 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091494009237 PYR/PP interface [polypeptide binding]; other site 1091494009238 dimer interface [polypeptide binding]; other site 1091494009239 TPP binding site [chemical binding]; other site 1091494009240 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091494009241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494009242 active site 1091494009243 VacJ like lipoprotein; Region: VacJ; cl01073 1091494009244 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1091494009245 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1091494009246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494009247 FeS/SAM binding site; other site 1091494009248 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1091494009249 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1091494009250 active site lid residues [active] 1091494009251 substrate binding pocket [chemical binding]; other site 1091494009252 catalytic residues [active] 1091494009253 substrate-Mg2+ binding site; other site 1091494009254 aspartate-rich region 1; other site 1091494009255 aspartate-rich region 2; other site 1091494009256 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1091494009257 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1091494009258 Active site cavity [active] 1091494009259 catalytic acid [active] 1091494009260 hopanoid-associated phosphorylase; Region: HpnG; TIGR03468 1091494009261 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1091494009262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494009263 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1091494009264 inhibitor-cofactor binding pocket; inhibition site 1091494009265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494009266 catalytic residue [active] 1091494009267 PemK-like protein; Region: PemK; cl00995 1091494009268 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1091494009269 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1091494009270 apolar tunnel; other site 1091494009271 heme binding site [chemical binding]; other site 1091494009272 dimerization interface [polypeptide binding]; other site 1091494009273 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1091494009274 YccA-like proteins; Region: YccA_like; cd10433 1091494009275 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1091494009276 putative active site [active] 1091494009277 catalytic residue [active] 1091494009278 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1091494009279 Domain of unknown function DUF21; Region: DUF21; pfam01595 1091494009280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1091494009281 Transporter associated domain; Region: CorC_HlyC; smart01091 1091494009282 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1091494009283 phosphopeptide binding site; other site 1091494009284 PilZ domain; Region: PilZ; pfam07238 1091494009285 DNA repair protein RadA; Provisional; Region: PRK11823 1091494009286 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1091494009287 Walker A motif; other site 1091494009288 ATP binding site [chemical binding]; other site 1091494009289 Walker B motif; other site 1091494009290 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1091494009291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091494009292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009293 active site 1091494009294 phosphorylation site [posttranslational modification] 1091494009295 intermolecular recognition site; other site 1091494009296 dimerization interface [polypeptide binding]; other site 1091494009297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494009298 DNA binding site [nucleotide binding] 1091494009299 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1091494009300 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1091494009301 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1091494009302 tandem repeat interface [polypeptide binding]; other site 1091494009303 oligomer interface [polypeptide binding]; other site 1091494009304 active site residues [active] 1091494009305 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1091494009306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494009307 motif II; other site 1091494009308 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1091494009309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091494009310 RNA binding surface [nucleotide binding]; other site 1091494009311 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1091494009312 active site 1091494009313 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1091494009314 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1091494009315 homodimer interface [polypeptide binding]; other site 1091494009316 oligonucleotide binding site [chemical binding]; other site 1091494009317 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1091494009318 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1091494009319 putative active site [active] 1091494009320 putative PHP Thumb interface [polypeptide binding]; other site 1091494009321 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1091494009322 generic binding surface II; other site 1091494009323 generic binding surface I; other site 1091494009324 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1091494009325 RNA/DNA hybrid binding site [nucleotide binding]; other site 1091494009326 active site 1091494009327 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1091494009328 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1091494009329 active site 1091494009330 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1091494009331 periplasmic chaperone; Provisional; Region: PRK10780 1091494009332 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1091494009333 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1091494009334 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1091494009335 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1091494009336 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1091494009337 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1091494009338 Surface antigen; Region: Bac_surface_Ag; pfam01103 1091494009339 Predicted ATPase [General function prediction only]; Region: COG1485 1091494009340 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1091494009341 active site 1091494009342 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 1091494009343 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1091494009344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494009345 active site 1091494009346 thymidine phosphorylase; Provisional; Region: PRK04350 1091494009347 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091494009348 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1091494009349 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1091494009350 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1091494009351 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1091494009352 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494009353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009354 active site 1091494009355 phosphorylation site [posttranslational modification] 1091494009356 intermolecular recognition site; other site 1091494009357 dimerization interface [polypeptide binding]; other site 1091494009358 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494009359 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1091494009360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494009361 S-adenosylmethionine binding site [chemical binding]; other site 1091494009362 CheD chemotactic sensory transduction; Region: CheD; cl00810 1091494009363 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1091494009364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009365 active site 1091494009366 phosphorylation site [posttranslational modification] 1091494009367 intermolecular recognition site; other site 1091494009368 dimerization interface [polypeptide binding]; other site 1091494009369 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494009370 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1091494009371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494009372 S-adenosylmethionine binding site [chemical binding]; other site 1091494009373 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1091494009374 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1091494009375 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1091494009376 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1091494009377 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1091494009378 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1091494009379 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1091494009380 UbiA prenyltransferase family; Region: UbiA; pfam01040 1091494009381 hypothetical protein; Validated; Region: PRK09071 1091494009382 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1091494009383 PilZ domain; Region: PilZ; pfam07238 1091494009384 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494009385 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494009386 catalytic residue [active] 1091494009387 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1091494009388 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1091494009389 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091494009390 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1091494009391 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1091494009392 putative CheA interaction surface; other site 1091494009393 CheW-like domain; Region: CheW; pfam01584 1091494009394 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091494009395 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494009396 Magnesium ion binding site [ion binding]; other site 1091494009397 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1091494009398 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1091494009399 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1091494009400 ligand binding site [chemical binding]; other site 1091494009401 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1091494009402 flagellar motor protein; Reviewed; Region: motC; PRK09109 1091494009403 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1091494009404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009405 active site 1091494009406 phosphorylation site [posttranslational modification] 1091494009407 intermolecular recognition site; other site 1091494009408 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494009409 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1091494009410 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494009411 putative binding surface; other site 1091494009412 active site 1091494009413 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1091494009414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494009415 ATP binding site [chemical binding]; other site 1091494009416 Mg2+ binding site [ion binding]; other site 1091494009417 G-X-G motif; other site 1091494009418 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1091494009419 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1091494009420 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1091494009421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009422 active site 1091494009423 phosphorylation site [posttranslational modification] 1091494009424 intermolecular recognition site; other site 1091494009425 dimerization interface [polypeptide binding]; other site 1091494009426 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1091494009427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494009428 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1091494009429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494009430 DNA binding residues [nucleotide binding] 1091494009431 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1091494009432 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1091494009433 P-loop; other site 1091494009434 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1091494009435 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1091494009436 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1091494009437 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1091494009438 FHIPEP family; Region: FHIPEP; pfam00771 1091494009439 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1091494009440 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1091494009441 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1091494009442 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1091494009443 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1091494009444 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1091494009445 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1091494009446 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1091494009447 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1091494009448 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1091494009449 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1091494009450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494009451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494009452 metal binding site [ion binding]; metal-binding site 1091494009453 active site 1091494009454 I-site; other site 1091494009455 Predicted membrane protein [Function unknown]; Region: COG4655 1091494009456 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1091494009457 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1091494009458 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 1091494009459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494009460 binding surface 1091494009461 TPR motif; other site 1091494009462 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1091494009463 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494009464 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1091494009465 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1091494009466 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1091494009467 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1091494009468 ATP binding site [chemical binding]; other site 1091494009469 Walker A motif; other site 1091494009470 hexamer interface [polypeptide binding]; other site 1091494009471 Walker B motif; other site 1091494009472 AAA domain; Region: AAA_31; pfam13614 1091494009473 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1091494009474 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1091494009475 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1091494009476 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1091494009477 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1091494009478 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1091494009479 TadE-like protein; Region: TadE; pfam07811 1091494009480 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1091494009481 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1091494009482 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1091494009483 amino acid carrier protein; Region: agcS; TIGR00835 1091494009484 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1091494009485 DNA-binding site [nucleotide binding]; DNA binding site 1091494009486 RNA-binding motif; other site 1091494009487 Protein of unknown function (DUF770); Region: DUF770; cl01402 1091494009488 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1091494009489 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1091494009490 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1091494009491 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1091494009492 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1091494009493 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1091494009494 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1091494009495 active site 1091494009496 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1091494009497 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1091494009498 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1091494009499 Peptidase family M50; Region: Peptidase_M50; pfam02163 1091494009500 active site 1091494009501 putative substrate binding region [chemical binding]; other site 1091494009502 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1091494009503 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1091494009504 Glycoprotease family; Region: Peptidase_M22; pfam00814 1091494009505 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1091494009506 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1091494009507 DEAD_2; Region: DEAD_2; pfam06733 1091494009508 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1091494009509 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1091494009510 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1091494009511 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1091494009512 trimer interface [polypeptide binding]; other site 1091494009513 active site 1091494009514 UDP-GlcNAc binding site [chemical binding]; other site 1091494009515 lipid binding site [chemical binding]; lipid-binding site 1091494009516 elongation factor G; Reviewed; Region: PRK00007 1091494009517 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1091494009518 G1 box; other site 1091494009519 putative GEF interaction site [polypeptide binding]; other site 1091494009520 GTP/Mg2+ binding site [chemical binding]; other site 1091494009521 Switch I region; other site 1091494009522 G2 box; other site 1091494009523 G3 box; other site 1091494009524 Switch II region; other site 1091494009525 G4 box; other site 1091494009526 G5 box; other site 1091494009527 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1091494009528 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1091494009529 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1091494009530 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1091494009531 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 1091494009532 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1091494009533 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1091494009534 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1091494009535 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1091494009536 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1091494009537 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1091494009538 catalytic triad [active] 1091494009539 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1091494009540 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1091494009541 putative active site [active] 1091494009542 PhoH-like protein; Region: PhoH; pfam02562 1091494009543 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1091494009544 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1091494009545 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 1091494009546 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1091494009547 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1091494009548 active site 1091494009549 catalytic site [active] 1091494009550 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1091494009551 Peptidase family M48; Region: Peptidase_M48; pfam01435 1091494009552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494009553 TPR motif; other site 1091494009554 binding surface 1091494009555 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1091494009556 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1091494009557 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1091494009558 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1091494009559 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1091494009560 CoA binding domain; Region: CoA_binding; smart00881 1091494009561 CoA-ligase; Region: Ligase_CoA; pfam00549 1091494009562 malate--CoA ligase subunit beta; Provisional; Region: PRK14046 1091494009563 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1091494009564 CoA-ligase; Region: Ligase_CoA; pfam00549 1091494009565 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1091494009566 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1091494009567 homodimer interface [polypeptide binding]; other site 1091494009568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494009569 catalytic residue [active] 1091494009570 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1091494009571 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1091494009572 dimerization interface [polypeptide binding]; other site 1091494009573 ligand binding site [chemical binding]; other site 1091494009574 NADP binding site [chemical binding]; other site 1091494009575 catalytic site [active] 1091494009576 malate dehydrogenase; Provisional; Region: PRK05442 1091494009577 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1091494009578 NAD(P) binding site [chemical binding]; other site 1091494009579 dimer interface [polypeptide binding]; other site 1091494009580 malate binding site [chemical binding]; other site 1091494009581 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 1091494009582 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 1091494009583 NADP binding site [chemical binding]; other site 1091494009584 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1091494009585 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1091494009586 MOFRL family; Region: MOFRL; pfam05161 1091494009587 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1091494009588 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1091494009589 dimer interface [polypeptide binding]; other site 1091494009590 active site 1091494009591 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1091494009592 folate binding site [chemical binding]; other site 1091494009593 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1091494009594 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1091494009595 Potassium binding sites [ion binding]; other site 1091494009596 Cesium cation binding sites [ion binding]; other site 1091494009597 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494009598 putative active site [active] 1091494009599 phosphomannomutase CpsG; Provisional; Region: PRK15414 1091494009600 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1091494009601 active site 1091494009602 substrate binding site [chemical binding]; other site 1091494009603 metal binding site [ion binding]; metal-binding site 1091494009604 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1091494009605 dimer interface [polypeptide binding]; other site 1091494009606 catalytic triad [active] 1091494009607 peroxidatic and resolving cysteines [active] 1091494009608 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1091494009609 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1091494009610 substrate binding site [chemical binding]; other site 1091494009611 active site 1091494009612 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1091494009613 Sporulation related domain; Region: SPOR; pfam05036 1091494009614 Evidence 2b : Function of strongly homologous gene; PubMedId : 15103156, 7901733; Product type e : enzyme 1091494009615 Evidence 2b : Function of strongly homologous gene; PubMedId : 15103156, 7901733; Product type e : enzyme 1091494009616 AMIN domain; Region: AMIN; pfam11741 1091494009617 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1091494009618 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1091494009619 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1091494009620 Pilus assembly protein, PilP; Region: PilP; pfam04351 1091494009621 Pilus assembly protein, PilO; Region: PilO; pfam04350 1091494009622 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1091494009623 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1091494009624 Cell division protein FtsA; Region: FtsA; cl17206 1091494009625 Competence protein A; Region: Competence_A; pfam11104 1091494009626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1091494009627 nucleotide binding site [chemical binding]; other site 1091494009628 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1091494009629 Transglycosylase; Region: Transgly; pfam00912 1091494009630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091494009631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1091494009632 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1091494009633 Na binding site [ion binding]; other site 1091494009634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494009635 TPR motif; other site 1091494009636 TPR repeat; Region: TPR_11; pfam13414 1091494009637 binding surface 1091494009638 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1091494009639 aspartate kinase; Validated; Region: PRK09181 1091494009640 AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248 1091494009641 putative catalytic residues [active] 1091494009642 putative nucleotide binding site [chemical binding]; other site 1091494009643 putative aspartate binding site [chemical binding]; other site 1091494009644 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910 1091494009645 allosteric regulatory residue; other site 1091494009646 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915 1091494009647 Ectoine synthase; Region: Ectoine_synth; pfam06339 1091494009648 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1091494009649 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494009650 inhibitor-cofactor binding pocket; inhibition site 1091494009651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494009652 catalytic residue [active] 1091494009653 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1091494009654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091494009655 Coenzyme A binding pocket [chemical binding]; other site 1091494009656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1091494009657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494009658 putative DNA binding site [nucleotide binding]; other site 1091494009659 putative Zn2+ binding site [ion binding]; other site 1091494009660 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1091494009661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494009662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494009663 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494009664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494009665 S-adenosylmethionine binding site [chemical binding]; other site 1091494009666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1091494009667 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1091494009668 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1091494009669 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1091494009670 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1091494009671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1091494009672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1091494009673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1091494009674 dimerization interface [polypeptide binding]; other site 1091494009675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494009676 S-adenosylmethionine binding site [chemical binding]; other site 1091494009677 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091494009678 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1091494009679 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1091494009680 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494009681 putative active site [active] 1091494009682 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1091494009683 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1091494009684 oligomeric interface; other site 1091494009685 putative active site [active] 1091494009686 homodimer interface [polypeptide binding]; other site 1091494009687 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1091494009688 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1091494009689 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091494009690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494009691 S-adenosylmethionine binding site [chemical binding]; other site 1091494009692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1091494009693 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1091494009694 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494009695 putative active site [active] 1091494009696 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1091494009697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494009698 non-specific DNA binding site [nucleotide binding]; other site 1091494009699 salt bridge; other site 1091494009700 sequence-specific DNA binding site [nucleotide binding]; other site 1091494009701 Predicted transcriptional regulator [Transcription]; Region: COG2944 1091494009702 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1091494009703 putative major pilin subunit; Provisional; Region: PRK10574 1091494009704 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1091494009705 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494009706 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494009707 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494009708 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1091494009709 Transposase; Region: HTH_Tnp_1; cl17663 1091494009710 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494009711 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494009712 Integrase core domain; Region: rve; pfam00665 1091494009713 Integrase core domain; Region: rve_3; pfam13683 1091494009714 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 1091494009715 muropeptide transporter; Validated; Region: ampG; cl17669 1091494009716 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1091494009717 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1091494009718 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1091494009719 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1091494009720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091494009721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091494009722 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1091494009723 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1091494009724 CoA binding domain; Region: CoA_binding; smart00881 1091494009725 CoA-ligase; Region: Ligase_CoA; pfam00549 1091494009726 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1091494009727 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1091494009728 CoA-ligase; Region: Ligase_CoA; pfam00549 1091494009729 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1091494009730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494009731 dimer interface [polypeptide binding]; other site 1091494009732 phosphorylation site [posttranslational modification] 1091494009733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494009734 ATP binding site [chemical binding]; other site 1091494009735 Mg2+ binding site [ion binding]; other site 1091494009736 G-X-G motif; other site 1091494009737 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494009738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494009739 active site 1091494009740 phosphorylation site [posttranslational modification] 1091494009741 intermolecular recognition site; other site 1091494009742 dimerization interface [polypeptide binding]; other site 1091494009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494009744 Walker A motif; other site 1091494009745 ATP binding site [chemical binding]; other site 1091494009746 Walker B motif; other site 1091494009747 arginine finger; other site 1091494009748 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494009749 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1091494009750 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091494009751 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1091494009752 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1091494009753 proline aminopeptidase P II; Provisional; Region: PRK10879 1091494009754 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1091494009755 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1091494009756 active site 1091494009757 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1091494009758 Cell division protein ZapA; Region: ZapA; pfam05164 1091494009759 EVE domain; Region: EVE; cl00728 1091494009760 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1091494009761 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1091494009762 active site 1091494009763 ADP/pyrophosphate binding site [chemical binding]; other site 1091494009764 dimerization interface [polypeptide binding]; other site 1091494009765 allosteric effector site; other site 1091494009766 fructose-1,6-bisphosphate binding site; other site 1091494009767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1091494009768 S-adenosylmethionine binding site [chemical binding]; other site 1091494009769 hypothetical protein; Provisional; Region: PRK01254 1091494009770 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1091494009771 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1091494009772 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1091494009773 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1091494009774 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1091494009775 Porin subfamily; Region: Porin_2; pfam02530 1091494009776 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1091494009777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1091494009778 Coenzyme A binding pocket [chemical binding]; other site 1091494009779 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1091494009780 Fe-S cluster binding site [ion binding]; other site 1091494009781 active site 1091494009782 2-isopropylmalate synthase; Validated; Region: PRK00915 1091494009783 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1091494009784 active site 1091494009785 catalytic residues [active] 1091494009786 metal binding site [ion binding]; metal-binding site 1091494009787 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1091494009788 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1091494009789 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1091494009790 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1091494009791 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1091494009792 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1091494009793 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1091494009794 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1091494009795 putative valine binding site [chemical binding]; other site 1091494009796 dimer interface [polypeptide binding]; other site 1091494009797 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1091494009798 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1091494009799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1091494009800 PYR/PP interface [polypeptide binding]; other site 1091494009801 dimer interface [polypeptide binding]; other site 1091494009802 TPP binding site [chemical binding]; other site 1091494009803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1091494009804 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1091494009805 TPP-binding site [chemical binding]; other site 1091494009806 dimer interface [polypeptide binding]; other site 1091494009807 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1091494009808 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1091494009809 tetramer interface [polypeptide binding]; other site 1091494009810 active site 1091494009811 Mg2+/Mn2+ binding site [ion binding]; other site 1091494009812 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1091494009813 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1091494009814 MoaE homodimer interface [polypeptide binding]; other site 1091494009815 MoaD interaction [polypeptide binding]; other site 1091494009816 active site residues [active] 1091494009817 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1091494009818 MoaE interaction surface [polypeptide binding]; other site 1091494009819 MoeB interaction surface [polypeptide binding]; other site 1091494009820 thiocarboxylated glycine; other site 1091494009821 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1091494009822 trimer interface [polypeptide binding]; other site 1091494009823 dimer interface [polypeptide binding]; other site 1091494009824 putative active site [active] 1091494009825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494009826 dimer interface [polypeptide binding]; other site 1091494009827 conserved gate region; other site 1091494009828 putative PBP binding loops; other site 1091494009829 ABC-ATPase subunit interface; other site 1091494009830 superoxide dismutase; Provisional; Region: PRK10543 1091494009831 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1091494009832 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1091494009833 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1091494009834 putative active site [active] 1091494009835 putative metal binding residues [ion binding]; other site 1091494009836 signature motif; other site 1091494009837 putative dimer interface [polypeptide binding]; other site 1091494009838 putative phosphate binding site [ion binding]; other site 1091494009839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494009840 TPR motif; other site 1091494009841 binding surface 1091494009842 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1091494009843 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1091494009844 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1091494009845 alphaNTD homodimer interface [polypeptide binding]; other site 1091494009846 alphaNTD - beta interaction site [polypeptide binding]; other site 1091494009847 alphaNTD - beta' interaction site [polypeptide binding]; other site 1091494009848 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1091494009849 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1091494009850 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1091494009851 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1091494009852 RNA binding surface [nucleotide binding]; other site 1091494009853 30S ribosomal protein S11; Validated; Region: PRK05309 1091494009854 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1091494009855 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1091494009856 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1091494009857 SecY translocase; Region: SecY; pfam00344 1091494009858 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1091494009859 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1091494009860 23S rRNA binding site [nucleotide binding]; other site 1091494009861 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1091494009862 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1091494009863 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1091494009864 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1091494009865 5S rRNA interface [nucleotide binding]; other site 1091494009866 23S rRNA interface [nucleotide binding]; other site 1091494009867 L5 interface [polypeptide binding]; other site 1091494009868 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1091494009869 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091494009870 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1091494009871 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1091494009872 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1091494009873 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1091494009874 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1091494009875 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1091494009876 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1091494009877 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1091494009878 RNA binding site [nucleotide binding]; other site 1091494009879 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1091494009880 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1091494009881 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1091494009882 23S rRNA interface [nucleotide binding]; other site 1091494009883 putative translocon interaction site; other site 1091494009884 signal recognition particle (SRP54) interaction site; other site 1091494009885 L23 interface [polypeptide binding]; other site 1091494009886 trigger factor interaction site; other site 1091494009887 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1091494009888 23S rRNA interface [nucleotide binding]; other site 1091494009889 5S rRNA interface [nucleotide binding]; other site 1091494009890 putative antibiotic binding site [chemical binding]; other site 1091494009891 L25 interface [polypeptide binding]; other site 1091494009892 L27 interface [polypeptide binding]; other site 1091494009893 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1091494009894 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1091494009895 G-X-X-G motif; other site 1091494009896 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1091494009897 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1091494009898 putative translocon binding site; other site 1091494009899 protein-rRNA interface [nucleotide binding]; other site 1091494009900 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1091494009901 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1091494009902 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1091494009903 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1091494009904 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1091494009905 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1091494009906 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1091494009907 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1091494009908 elongation factor Tu; Reviewed; Region: PRK00049 1091494009909 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1091494009910 G1 box; other site 1091494009911 GEF interaction site [polypeptide binding]; other site 1091494009912 GTP/Mg2+ binding site [chemical binding]; other site 1091494009913 Switch I region; other site 1091494009914 G2 box; other site 1091494009915 G3 box; other site 1091494009916 Switch II region; other site 1091494009917 G4 box; other site 1091494009918 G5 box; other site 1091494009919 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1091494009920 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1091494009921 Antibiotic Binding Site [chemical binding]; other site 1091494009922 elongation factor G; Reviewed; Region: PRK00007 1091494009923 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1091494009924 G1 box; other site 1091494009925 putative GEF interaction site [polypeptide binding]; other site 1091494009926 GTP/Mg2+ binding site [chemical binding]; other site 1091494009927 Switch I region; other site 1091494009928 G2 box; other site 1091494009929 G3 box; other site 1091494009930 Switch II region; other site 1091494009931 G4 box; other site 1091494009932 G5 box; other site 1091494009933 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1091494009934 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1091494009935 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1091494009936 30S ribosomal protein S7; Validated; Region: PRK05302 1091494009937 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1091494009938 S17 interaction site [polypeptide binding]; other site 1091494009939 S8 interaction site; other site 1091494009940 16S rRNA interaction site [nucleotide binding]; other site 1091494009941 streptomycin interaction site [chemical binding]; other site 1091494009942 23S rRNA interaction site [nucleotide binding]; other site 1091494009943 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1091494009944 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1091494009945 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1091494009946 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1091494009947 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1091494009948 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1091494009949 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1091494009950 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1091494009951 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1091494009952 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1091494009953 DNA binding site [nucleotide binding] 1091494009954 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1091494009955 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1091494009956 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1091494009957 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1091494009958 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1091494009959 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1091494009960 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1091494009961 RPB3 interaction site [polypeptide binding]; other site 1091494009962 RPB1 interaction site [polypeptide binding]; other site 1091494009963 RPB11 interaction site [polypeptide binding]; other site 1091494009964 RPB10 interaction site [polypeptide binding]; other site 1091494009965 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1091494009966 peripheral dimer interface [polypeptide binding]; other site 1091494009967 core dimer interface [polypeptide binding]; other site 1091494009968 L10 interface [polypeptide binding]; other site 1091494009969 L11 interface [polypeptide binding]; other site 1091494009970 putative EF-Tu interaction site [polypeptide binding]; other site 1091494009971 putative EF-G interaction site [polypeptide binding]; other site 1091494009972 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1091494009973 23S rRNA interface [nucleotide binding]; other site 1091494009974 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1091494009975 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1091494009976 mRNA/rRNA interface [nucleotide binding]; other site 1091494009977 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1091494009978 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1091494009979 23S rRNA interface [nucleotide binding]; other site 1091494009980 L7/L12 interface [polypeptide binding]; other site 1091494009981 putative thiostrepton binding site; other site 1091494009982 L25 interface [polypeptide binding]; other site 1091494009983 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1091494009984 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1091494009985 putative homodimer interface [polypeptide binding]; other site 1091494009986 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1091494009987 heterodimer interface [polypeptide binding]; other site 1091494009988 homodimer interface [polypeptide binding]; other site 1091494009989 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1091494009990 elongation factor Tu; Reviewed; Region: PRK00049 1091494009991 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1091494009992 G1 box; other site 1091494009993 GEF interaction site [polypeptide binding]; other site 1091494009994 GTP/Mg2+ binding site [chemical binding]; other site 1091494009995 Switch I region; other site 1091494009996 G2 box; other site 1091494009997 G3 box; other site 1091494009998 Switch II region; other site 1091494009999 G4 box; other site 1091494010000 G5 box; other site 1091494010001 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1091494010002 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1091494010003 Antibiotic Binding Site [chemical binding]; other site 1091494010004 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1091494010005 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1091494010006 5S rRNA interface [nucleotide binding]; other site 1091494010007 CTC domain interface [polypeptide binding]; other site 1091494010008 L16 interface [polypeptide binding]; other site 1091494010009 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1091494010010 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1091494010011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494010012 active site 1091494010013 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1091494010014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1091494010015 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1091494010016 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1091494010017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1091494010018 binding surface 1091494010019 TPR motif; other site 1091494010020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494010021 binding surface 1091494010022 TPR motif; other site 1091494010023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1091494010024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494010025 binding surface 1091494010026 TPR motif; other site 1091494010027 TPR repeat; Region: TPR_11; pfam13414 1091494010028 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1091494010029 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1091494010030 tRNA; other site 1091494010031 putative tRNA binding site [nucleotide binding]; other site 1091494010032 putative NADP binding site [chemical binding]; other site 1091494010033 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1091494010034 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1091494010035 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1091494010036 RF-1 domain; Region: RF-1; pfam00472 1091494010037 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1091494010038 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091494010039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010040 S-adenosylmethionine binding site [chemical binding]; other site 1091494010041 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1091494010042 MPN+ (JAMM) motif; other site 1091494010043 Zinc-binding site [ion binding]; other site 1091494010044 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494010045 putative active site [active] 1091494010046 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1091494010047 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1091494010048 GatB domain; Region: GatB_Yqey; smart00845 1091494010049 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494010050 putative active site [active] 1091494010051 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1091494010052 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1091494010053 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1091494010054 rod shape-determining protein MreB; Provisional; Region: PRK13927 1091494010055 MreB and similar proteins; Region: MreB_like; cd10225 1091494010056 nucleotide binding site [chemical binding]; other site 1091494010057 Mg binding site [ion binding]; other site 1091494010058 putative protofilament interaction site [polypeptide binding]; other site 1091494010059 RodZ interaction site [polypeptide binding]; other site 1091494010060 rod shape-determining protein MreC; Provisional; Region: PRK13922 1091494010061 rod shape-determining protein MreC; Region: MreC; pfam04085 1091494010062 rod shape-determining protein MreD; Region: MreD; cl01087 1091494010063 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1091494010064 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1091494010065 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091494010066 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1091494010067 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1091494010068 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494010069 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494010070 Sporulation related domain; Region: SPOR; pfam05036 1091494010071 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1091494010072 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1091494010073 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1091494010074 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1091494010075 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1091494010076 homodimer interface [polypeptide binding]; other site 1091494010077 substrate-cofactor binding pocket; other site 1091494010078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494010079 catalytic residue [active] 1091494010080 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1091494010081 lipoate-protein ligase B; Provisional; Region: PRK14342 1091494010082 lipoyl synthase; Provisional; Region: PRK05481 1091494010083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494010084 FeS/SAM binding site; other site 1091494010085 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1091494010086 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1091494010087 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1091494010088 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1091494010089 RNA binding site [nucleotide binding]; other site 1091494010090 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1091494010091 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 1091494010092 active site 1091494010093 metal binding site [ion binding]; metal-binding site 1091494010094 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1091494010095 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1091494010096 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1091494010097 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1091494010098 putative active site [active] 1091494010099 catalytic triad [active] 1091494010100 putative dimer interface [polypeptide binding]; other site 1091494010101 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1091494010102 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1091494010103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494010104 Zn2+ binding site [ion binding]; other site 1091494010105 Mg2+ binding site [ion binding]; other site 1091494010106 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1091494010107 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494010108 P-loop; other site 1091494010109 Magnesium ion binding site [ion binding]; other site 1091494010110 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1091494010111 Magnesium ion binding site [ion binding]; other site 1091494010112 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 1091494010113 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1091494010114 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1091494010115 HIGH motif; other site 1091494010116 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1091494010117 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1091494010118 active site 1091494010119 KMSKS motif; other site 1091494010120 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1091494010121 tRNA binding surface [nucleotide binding]; other site 1091494010122 Lipopolysaccharide-assembly; Region: LptE; cl01125 1091494010123 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1091494010124 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1091494010125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494010126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010127 ATP binding site [chemical binding]; other site 1091494010128 Mg2+ binding site [ion binding]; other site 1091494010129 G-X-G motif; other site 1091494010130 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1091494010131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010132 active site 1091494010133 phosphorylation site [posttranslational modification] 1091494010134 intermolecular recognition site; other site 1091494010135 dimerization interface [polypeptide binding]; other site 1091494010136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494010137 TPR motif; other site 1091494010138 binding surface 1091494010139 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494010140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494010141 binding surface 1091494010142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494010143 TPR motif; other site 1091494010144 heat shock protein 90; Provisional; Region: PRK05218 1091494010145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010146 ATP binding site [chemical binding]; other site 1091494010147 Mg2+ binding site [ion binding]; other site 1091494010148 G-X-G motif; other site 1091494010149 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1091494010150 spermidine synthase; Provisional; Region: PRK00811 1091494010151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010152 S-adenosylmethionine binding site [chemical binding]; other site 1091494010153 arginine decarboxylase; Provisional; Region: PRK05354 1091494010154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1091494010155 dimer interface [polypeptide binding]; other site 1091494010156 active site 1091494010157 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1091494010158 catalytic residues [active] 1091494010159 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1091494010160 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1091494010161 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091494010162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1091494010163 Walker A/P-loop; other site 1091494010164 ATP binding site [chemical binding]; other site 1091494010165 Q-loop/lid; other site 1091494010166 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1091494010167 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1091494010168 proposed active site lysine [active] 1091494010169 conserved cys residue [active] 1091494010170 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091494010171 nucleoside/Zn binding site; other site 1091494010172 dimer interface [polypeptide binding]; other site 1091494010173 catalytic motif [active] 1091494010174 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1091494010175 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1091494010176 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1091494010177 dimerization interface [polypeptide binding]; other site 1091494010178 putative ATP binding site [chemical binding]; other site 1091494010179 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1091494010180 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091494010181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091494010182 active site 1091494010183 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1091494010184 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1091494010185 PhnA protein; Region: PhnA; pfam03831 1091494010186 DNA topoisomerase I; Validated; Region: PRK06599 1091494010187 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1091494010188 active site 1091494010189 interdomain interaction site; other site 1091494010190 putative metal-binding site [ion binding]; other site 1091494010191 nucleotide binding site [chemical binding]; other site 1091494010192 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1091494010193 domain I; other site 1091494010194 DNA binding groove [nucleotide binding] 1091494010195 phosphate binding site [ion binding]; other site 1091494010196 domain II; other site 1091494010197 domain III; other site 1091494010198 nucleotide binding site [chemical binding]; other site 1091494010199 catalytic site [active] 1091494010200 domain IV; other site 1091494010201 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1091494010202 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1091494010203 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1091494010204 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1091494010205 Protein of unknown function (DUF494); Region: DUF494; pfam04361 1091494010206 DNA protecting protein DprA; Region: dprA; TIGR00732 1091494010207 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1091494010208 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1091494010209 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1091494010210 active site 1091494010211 catalytic residues [active] 1091494010212 metal binding site [ion binding]; metal-binding site 1091494010213 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1091494010214 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1091494010215 putative active site [active] 1091494010216 substrate binding site [chemical binding]; other site 1091494010217 putative cosubstrate binding site; other site 1091494010218 catalytic site [active] 1091494010219 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1091494010220 substrate binding site [chemical binding]; other site 1091494010221 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1091494010222 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1091494010223 putative RNA binding site [nucleotide binding]; other site 1091494010224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010225 S-adenosylmethionine binding site [chemical binding]; other site 1091494010226 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1091494010227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494010228 dimerization interface [polypeptide binding]; other site 1091494010229 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1091494010230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010231 putative active site [active] 1091494010232 heme pocket [chemical binding]; other site 1091494010233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494010234 dimer interface [polypeptide binding]; other site 1091494010235 phosphorylation site [posttranslational modification] 1091494010236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010237 ATP binding site [chemical binding]; other site 1091494010238 Mg2+ binding site [ion binding]; other site 1091494010239 G-X-G motif; other site 1091494010240 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494010241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010242 active site 1091494010243 phosphorylation site [posttranslational modification] 1091494010244 intermolecular recognition site; other site 1091494010245 dimerization interface [polypeptide binding]; other site 1091494010246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010247 Walker A motif; other site 1091494010248 ATP binding site [chemical binding]; other site 1091494010249 Walker B motif; other site 1091494010250 arginine finger; other site 1091494010251 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1091494010252 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1091494010253 23S rRNA interface [nucleotide binding]; other site 1091494010254 L3 interface [polypeptide binding]; other site 1091494010255 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1091494010256 threonine dehydratase; Reviewed; Region: PRK09224 1091494010257 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1091494010258 tetramer interface [polypeptide binding]; other site 1091494010259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494010260 catalytic residue [active] 1091494010261 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1091494010262 putative Ile/Val binding site [chemical binding]; other site 1091494010263 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1091494010264 putative Ile/Val binding site [chemical binding]; other site 1091494010265 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1091494010266 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1091494010267 active site 1091494010268 dimer interface [polypeptide binding]; other site 1091494010269 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494010270 metal ion-dependent adhesion site (MIDAS); other site 1091494010271 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494010272 metal ion-dependent adhesion site (MIDAS); other site 1091494010273 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091494010274 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091494010275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010276 Walker A motif; other site 1091494010277 ATP binding site [chemical binding]; other site 1091494010278 Walker B motif; other site 1091494010279 arginine finger; other site 1091494010280 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 1091494010281 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 1091494010282 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 1091494010283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494010284 membrane-bound complex binding site; other site 1091494010285 hinge residues; other site 1091494010286 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1091494010287 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1091494010288 Trp docking motif [polypeptide binding]; other site 1091494010289 dimer interface [polypeptide binding]; other site 1091494010290 active site 1091494010291 small subunit binding site [polypeptide binding]; other site 1091494010292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494010293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010294 active site 1091494010295 phosphorylation site [posttranslational modification] 1091494010296 intermolecular recognition site; other site 1091494010297 dimerization interface [polypeptide binding]; other site 1091494010298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494010299 DNA binding residues [nucleotide binding] 1091494010300 dimerization interface [polypeptide binding]; other site 1091494010301 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 1091494010302 active site 1091494010303 zinc binding site [ion binding]; other site 1091494010304 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1091494010305 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494010306 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494010307 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1091494010308 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cd00326 1091494010309 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1091494010310 putative hydrophobic ligand binding site [chemical binding]; other site 1091494010311 protein interface [polypeptide binding]; other site 1091494010312 gate; other site 1091494010313 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1091494010314 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1091494010315 Beta-Casp domain; Region: Beta-Casp; smart01027 1091494010316 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1091494010317 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1091494010318 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1091494010319 oligomer interface [polypeptide binding]; other site 1091494010320 metal binding site [ion binding]; metal-binding site 1091494010321 metal binding site [ion binding]; metal-binding site 1091494010322 Cl binding site [ion binding]; other site 1091494010323 aspartate ring; other site 1091494010324 basic sphincter; other site 1091494010325 putative hydrophobic gate; other site 1091494010326 periplasmic entrance; other site 1091494010327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010328 S-adenosylmethionine binding site [chemical binding]; other site 1091494010329 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1091494010330 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1091494010331 putative active site [active] 1091494010332 Zn binding site [ion binding]; other site 1091494010333 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1091494010334 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1091494010335 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1091494010336 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1091494010337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494010338 FeS/SAM binding site; other site 1091494010339 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1091494010340 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1091494010341 recombination factor protein RarA; Reviewed; Region: PRK13342 1091494010342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010343 Walker A motif; other site 1091494010344 ATP binding site [chemical binding]; other site 1091494010345 Walker B motif; other site 1091494010346 arginine finger; other site 1091494010347 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1091494010348 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1091494010349 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1091494010350 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1091494010351 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1091494010352 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1091494010353 shikimate binding site; other site 1091494010354 NAD(P) binding site [chemical binding]; other site 1091494010355 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1091494010356 dimer interface [polypeptide binding]; other site 1091494010357 allosteric magnesium binding site [ion binding]; other site 1091494010358 active site 1091494010359 aspartate-rich active site metal binding site; other site 1091494010360 Schiff base residues; other site 1091494010361 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1091494010362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010363 S-adenosylmethionine binding site [chemical binding]; other site 1091494010364 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1091494010365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010366 S-adenosylmethionine binding site [chemical binding]; other site 1091494010367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1091494010368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1091494010369 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1091494010370 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1091494010371 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1091494010372 GIY-YIG motif/motif A; other site 1091494010373 active site 1091494010374 catalytic site [active] 1091494010375 putative DNA binding site [nucleotide binding]; other site 1091494010376 metal binding site [ion binding]; metal-binding site 1091494010377 UvrB/uvrC motif; Region: UVR; pfam02151 1091494010378 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1091494010379 potential frameshift: common BLAST hit: gi|333982988|ref|YP_004512198.1| uracil-DNA glycosylase superfamily protein 1091494010380 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1091494010381 active site 1091494010382 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1091494010383 ligand binding site [chemical binding]; other site 1091494010384 peptidase PmbA; Provisional; Region: PRK11040 1091494010385 protease TldD; Provisional; Region: tldD; PRK10735 1091494010386 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1091494010387 nitrilase; Region: PLN02798 1091494010388 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1091494010389 putative active site [active] 1091494010390 catalytic triad [active] 1091494010391 dimer interface [polypeptide binding]; other site 1091494010392 TIGR02099 family protein; Region: TIGR02099 1091494010393 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1091494010394 ribonuclease G; Provisional; Region: PRK11712 1091494010395 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1091494010396 homodimer interface [polypeptide binding]; other site 1091494010397 oligonucleotide binding site [chemical binding]; other site 1091494010398 Maf-like protein; Region: Maf; pfam02545 1091494010399 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1091494010400 active site 1091494010401 dimer interface [polypeptide binding]; other site 1091494010402 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1091494010403 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091494010404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010405 Walker A motif; other site 1091494010406 ATP binding site [chemical binding]; other site 1091494010407 Walker B motif; other site 1091494010408 arginine finger; other site 1091494010409 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091494010410 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1091494010411 metal ion-dependent adhesion site (MIDAS); other site 1091494010412 Ion transport protein; Region: Ion_trans; pfam00520 1091494010413 Ion channel; Region: Ion_trans_2; pfam07885 1091494010414 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1091494010415 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1091494010416 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1091494010417 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1091494010418 active site 1091494010419 HIGH motif; other site 1091494010420 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1091494010421 KMSKS motif; other site 1091494010422 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1091494010423 tRNA binding surface [nucleotide binding]; other site 1091494010424 anticodon binding site; other site 1091494010425 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1091494010426 substrate binding site [chemical binding]; other site 1091494010427 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091494010428 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1091494010429 putative active site [active] 1091494010430 putative metal binding site [ion binding]; other site 1091494010431 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1091494010432 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1091494010433 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494010434 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494010435 ligand binding site [chemical binding]; other site 1091494010436 flexible hinge region; other site 1091494010437 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1091494010438 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1091494010439 Trp docking motif [polypeptide binding]; other site 1091494010440 dimer interface [polypeptide binding]; other site 1091494010441 active site 1091494010442 small subunit binding site [polypeptide binding]; other site 1091494010443 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1091494010444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1091494010445 membrane-bound complex binding site; other site 1091494010446 hinge residues; other site 1091494010447 glycogen branching enzyme; Provisional; Region: PRK05402 1091494010448 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1091494010449 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1091494010450 active site 1091494010451 catalytic site [active] 1091494010452 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1091494010453 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1091494010454 active site 1091494010455 catalytic site [active] 1091494010456 glycogen synthase; Provisional; Region: glgA; PRK00654 1091494010457 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1091494010458 ADP-binding pocket [chemical binding]; other site 1091494010459 homodimer interface [polypeptide binding]; other site 1091494010460 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1091494010461 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1091494010462 active site 1091494010463 substrate binding site [chemical binding]; other site 1091494010464 catalytic site [active] 1091494010465 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1091494010466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1091494010467 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1091494010468 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1091494010469 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1091494010470 putative active site [active] 1091494010471 catalytic site [active] 1091494010472 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1091494010473 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1091494010474 ligand binding site; other site 1091494010475 oligomer interface; other site 1091494010476 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1091494010477 dimer interface [polypeptide binding]; other site 1091494010478 N-terminal domain interface [polypeptide binding]; other site 1091494010479 sulfate 1 binding site; other site 1091494010480 glycogen branching enzyme; Provisional; Region: PRK05402 1091494010481 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1091494010482 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1091494010483 active site 1091494010484 catalytic site [active] 1091494010485 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1091494010486 glycogen synthase; Provisional; Region: glgA; PRK00654 1091494010487 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1091494010488 ADP-binding pocket [chemical binding]; other site 1091494010489 homodimer interface [polypeptide binding]; other site 1091494010490 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1091494010491 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1091494010492 SurA N-terminal domain; Region: SurA_N; pfam09312 1091494010493 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1091494010494 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1091494010495 organic solvent tolerance protein; Provisional; Region: PRK04423 1091494010496 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1091494010497 Phosphotransferase enzyme family; Region: APH; pfam01636 1091494010498 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1091494010499 substrate binding site [chemical binding]; other site 1091494010500 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1091494010501 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1091494010502 Substrate binding site; other site 1091494010503 metal-binding site 1091494010504 Dodecin; Region: Dodecin; pfam07311 1091494010505 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1091494010506 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1091494010507 beta-hexosaminidase; Provisional; Region: PRK05337 1091494010508 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1091494010509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494010510 active site 1091494010511 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1091494010512 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1091494010513 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1091494010514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1091494010515 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494010516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010517 active site 1091494010518 phosphorylation site [posttranslational modification] 1091494010519 intermolecular recognition site; other site 1091494010520 dimerization interface [polypeptide binding]; other site 1091494010521 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494010522 putative binding surface; other site 1091494010523 active site 1091494010524 FimV N-terminal domain; Region: FimV_core; TIGR03505 1091494010525 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1091494010526 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1091494010527 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1091494010528 Low affinity iron permease; Region: Iron_permease; pfam04120 1091494010529 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1091494010530 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1091494010531 substrate binding site [chemical binding]; other site 1091494010532 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1091494010533 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1091494010534 substrate binding site [chemical binding]; other site 1091494010535 ligand binding site [chemical binding]; other site 1091494010536 adenylate kinase; Reviewed; Region: adk; PRK00279 1091494010537 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1091494010538 AMP-binding site [chemical binding]; other site 1091494010539 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1091494010540 FOG: CBS domain [General function prediction only]; Region: COG0517 1091494010541 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1091494010542 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1091494010543 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1091494010544 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1091494010545 TraB family; Region: TraB; pfam01963 1091494010546 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1091494010547 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1091494010548 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1091494010549 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1091494010550 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1091494010551 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1091494010552 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1091494010553 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1091494010554 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1091494010555 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1091494010556 active site 1091494010557 HslU subunit interaction site [polypeptide binding]; other site 1091494010558 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1091494010559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010560 Walker A motif; other site 1091494010561 ATP binding site [chemical binding]; other site 1091494010562 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1091494010563 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1091494010564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1091494010565 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1091494010566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010567 S-adenosylmethionine binding site [chemical binding]; other site 1091494010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1091494010569 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1091494010570 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1091494010571 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1091494010572 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1091494010573 Phosphoglycerate kinase; Region: PGK; pfam00162 1091494010574 substrate binding site [chemical binding]; other site 1091494010575 hinge regions; other site 1091494010576 ADP binding site [chemical binding]; other site 1091494010577 catalytic site [active] 1091494010578 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1091494010579 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1091494010580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1091494010581 Zn2+ binding site [ion binding]; other site 1091494010582 Mg2+ binding site [ion binding]; other site 1091494010583 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1091494010584 synthetase active site [active] 1091494010585 NTP binding site [chemical binding]; other site 1091494010586 metal binding site [ion binding]; metal-binding site 1091494010587 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1091494010588 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1091494010589 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1091494010590 homotrimer interaction site [polypeptide binding]; other site 1091494010591 putative active site [active] 1091494010592 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1091494010593 Y-family of DNA polymerases; Region: PolY; cl12025 1091494010594 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1091494010595 ssDNA binding site; other site 1091494010596 generic binding surface II; other site 1091494010597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494010598 ATP binding site [chemical binding]; other site 1091494010599 putative Mg++ binding site [ion binding]; other site 1091494010600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494010601 nucleotide binding region [chemical binding]; other site 1091494010602 ATP-binding site [chemical binding]; other site 1091494010603 Chorismate lyase; Region: Chor_lyase; cl01230 1091494010604 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1091494010605 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494010606 inhibitor-cofactor binding pocket; inhibition site 1091494010607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494010608 catalytic residue [active] 1091494010609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494010610 S-adenosylmethionine binding site [chemical binding]; other site 1091494010611 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 1091494010612 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1091494010613 dimerization interface [polypeptide binding]; other site 1091494010614 active site 1091494010615 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1091494010616 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1091494010617 metal binding site [ion binding]; metal-binding site 1091494010618 putative dimer interface [polypeptide binding]; other site 1091494010619 LexA repressor; Validated; Region: PRK00215 1091494010620 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1091494010621 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1091494010622 Catalytic site [active] 1091494010623 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1091494010624 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494010625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010626 active site 1091494010627 phosphorylation site [posttranslational modification] 1091494010628 intermolecular recognition site; other site 1091494010629 dimerization interface [polypeptide binding]; other site 1091494010630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010631 PAS domain; Region: PAS_9; pfam13426 1091494010632 putative active site [active] 1091494010633 heme pocket [chemical binding]; other site 1091494010634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494010635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494010636 metal binding site [ion binding]; metal-binding site 1091494010637 active site 1091494010638 I-site; other site 1091494010639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494010640 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1091494010641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494010642 dimerization interface [polypeptide binding]; other site 1091494010643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494010644 dimer interface [polypeptide binding]; other site 1091494010645 phosphorylation site [posttranslational modification] 1091494010646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010647 ATP binding site [chemical binding]; other site 1091494010648 Mg2+ binding site [ion binding]; other site 1091494010649 G-X-G motif; other site 1091494010650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010651 active site 1091494010652 phosphorylation site [posttranslational modification] 1091494010653 intermolecular recognition site; other site 1091494010654 dimerization interface [polypeptide binding]; other site 1091494010655 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1091494010656 putative binding surface; other site 1091494010657 active site 1091494010658 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1091494010659 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1091494010660 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494010661 N-terminal plug; other site 1091494010662 ligand-binding site [chemical binding]; other site 1091494010663 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1091494010664 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1091494010665 active site 1091494010666 dimerization interface [polypeptide binding]; other site 1091494010667 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1091494010668 dimer interface [polypeptide binding]; other site 1091494010669 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1091494010670 active site 1091494010671 HDOD domain; Region: HDOD; pfam08668 1091494010672 GAF domain; Region: GAF_3; pfam13492 1091494010673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010674 ATP binding site [chemical binding]; other site 1091494010675 Mg2+ binding site [ion binding]; other site 1091494010676 G-X-G motif; other site 1091494010677 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494010678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010679 active site 1091494010680 phosphorylation site [posttranslational modification] 1091494010681 intermolecular recognition site; other site 1091494010682 dimerization interface [polypeptide binding]; other site 1091494010683 PAS domain S-box; Region: sensory_box; TIGR00229 1091494010684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010685 putative active site [active] 1091494010686 heme pocket [chemical binding]; other site 1091494010687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010688 PAS domain; Region: PAS_9; pfam13426 1091494010689 putative active site [active] 1091494010690 heme pocket [chemical binding]; other site 1091494010691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494010692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494010693 metal binding site [ion binding]; metal-binding site 1091494010694 active site 1091494010695 I-site; other site 1091494010696 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494010697 Zeta toxin; Region: Zeta_toxin; pfam06414 1091494010698 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1091494010699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494010700 active site 1091494010701 phosphorylation site [posttranslational modification] 1091494010702 intermolecular recognition site; other site 1091494010703 dimerization interface [polypeptide binding]; other site 1091494010704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494010705 DNA binding residues [nucleotide binding] 1091494010706 dimerization interface [polypeptide binding]; other site 1091494010707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010708 PAS fold; Region: PAS_3; pfam08447 1091494010709 putative active site [active] 1091494010710 heme pocket [chemical binding]; other site 1091494010711 PAS domain S-box; Region: sensory_box; TIGR00229 1091494010712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010713 putative active site [active] 1091494010714 heme pocket [chemical binding]; other site 1091494010715 hypothetical protein; Provisional; Region: PRK13560 1091494010716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010717 putative active site [active] 1091494010718 heme pocket [chemical binding]; other site 1091494010719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494010720 dimer interface [polypeptide binding]; other site 1091494010721 phosphorylation site [posttranslational modification] 1091494010722 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1091494010723 G4 box; other site 1091494010724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494010725 ATP binding site [chemical binding]; other site 1091494010726 Mg2+ binding site [ion binding]; other site 1091494010727 G-X-G motif; other site 1091494010728 PAS domain S-box; Region: sensory_box; TIGR00229 1091494010729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010730 putative active site [active] 1091494010731 heme pocket [chemical binding]; other site 1091494010732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494010733 PAS domain; Region: PAS_9; pfam13426 1091494010734 putative active site [active] 1091494010735 heme pocket [chemical binding]; other site 1091494010736 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494010737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494010738 metal binding site [ion binding]; metal-binding site 1091494010739 active site 1091494010740 I-site; other site 1091494010741 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494010742 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1091494010743 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1091494010744 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1091494010745 dimerization interface [polypeptide binding]; other site 1091494010746 active site 1091494010747 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1091494010748 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1091494010749 amidase catalytic site [active] 1091494010750 Zn binding residues [ion binding]; other site 1091494010751 substrate binding site [chemical binding]; other site 1091494010752 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1091494010753 lipoprotein signal peptidase; Provisional; Region: PRK14787 1091494010754 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1091494010755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1091494010756 active site 1091494010757 HIGH motif; other site 1091494010758 nucleotide binding site [chemical binding]; other site 1091494010759 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1091494010760 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1091494010761 active site 1091494010762 KMSKS motif; other site 1091494010763 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1091494010764 tRNA binding surface [nucleotide binding]; other site 1091494010765 anticodon binding site; other site 1091494010766 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1091494010767 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1091494010768 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1091494010769 active site 1091494010770 Riboflavin kinase; Region: Flavokinase; smart00904 1091494010771 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1091494010772 gamma-glutamyl kinase; Provisional; Region: PRK05429 1091494010773 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1091494010774 nucleotide binding site [chemical binding]; other site 1091494010775 homotetrameric interface [polypeptide binding]; other site 1091494010776 putative phosphate binding site [ion binding]; other site 1091494010777 putative allosteric binding site; other site 1091494010778 PUA domain; Region: PUA; pfam01472 1091494010779 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1091494010780 GTP1/OBG; Region: GTP1_OBG; pfam01018 1091494010781 Obg GTPase; Region: Obg; cd01898 1091494010782 G1 box; other site 1091494010783 GTP/Mg2+ binding site [chemical binding]; other site 1091494010784 Switch I region; other site 1091494010785 G2 box; other site 1091494010786 G3 box; other site 1091494010787 Switch II region; other site 1091494010788 G4 box; other site 1091494010789 G5 box; other site 1091494010790 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1091494010791 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1091494010792 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1091494010793 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1091494010794 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1091494010795 substrate binding pocket [chemical binding]; other site 1091494010796 chain length determination region; other site 1091494010797 substrate-Mg2+ binding site; other site 1091494010798 catalytic residues [active] 1091494010799 aspartate-rich region 1; other site 1091494010800 active site lid residues [active] 1091494010801 aspartate-rich region 2; other site 1091494010802 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1091494010803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010804 Walker A motif; other site 1091494010805 ATP binding site [chemical binding]; other site 1091494010806 Walker B motif; other site 1091494010807 arginine finger; other site 1091494010808 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1091494010809 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1091494010810 active site clefts [active] 1091494010811 zinc binding site [ion binding]; other site 1091494010812 dimer interface [polypeptide binding]; other site 1091494010813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1091494010814 active site 1091494010815 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1091494010816 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1091494010817 cell division protein FtsZ; Validated; Region: PRK09330 1091494010818 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1091494010819 nucleotide binding site [chemical binding]; other site 1091494010820 SulA interaction site; other site 1091494010821 cell division protein FtsA; Region: ftsA; TIGR01174 1091494010822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1091494010823 nucleotide binding site [chemical binding]; other site 1091494010824 Cell division protein FtsA; Region: FtsA; pfam14450 1091494010825 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1091494010826 Cell division protein FtsQ; Region: FtsQ; pfam03799 1091494010827 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1091494010828 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1091494010829 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1091494010830 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1091494010831 FAD binding domain; Region: FAD_binding_4; pfam01565 1091494010832 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1091494010833 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1091494010834 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091494010835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091494010836 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494010837 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1091494010838 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1091494010839 active site 1091494010840 homodimer interface [polypeptide binding]; other site 1091494010841 cell division protein FtsW; Region: ftsW; TIGR02614 1091494010842 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1091494010843 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091494010844 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494010845 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1091494010846 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1091494010847 Mg++ binding site [ion binding]; other site 1091494010848 putative catalytic motif [active] 1091494010849 putative substrate binding site [chemical binding]; other site 1091494010850 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1091494010851 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091494010852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091494010853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494010854 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1091494010855 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091494010856 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091494010857 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494010858 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1091494010859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1091494010860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1091494010861 Cell division protein FtsL; Region: FtsL; pfam04999 1091494010862 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1091494010863 MraW methylase family; Region: Methyltransf_5; cl17771 1091494010864 MraZ protein; Region: MraZ; pfam02381 1091494010865 cell division protein MraZ; Reviewed; Region: PRK00326 1091494010866 MraZ protein; Region: MraZ; pfam02381 1091494010867 Predicted methyltransferases [General function prediction only]; Region: COG0313 1091494010868 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1091494010869 putative SAM binding site [chemical binding]; other site 1091494010870 putative homodimer interface [polypeptide binding]; other site 1091494010871 LppC putative lipoprotein; Region: LppC; pfam04348 1091494010872 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1091494010873 putative ligand binding site [chemical binding]; other site 1091494010874 hypothetical protein; Reviewed; Region: PRK12497 1091494010875 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1091494010876 dimer interface [polypeptide binding]; other site 1091494010877 active site 1091494010878 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1091494010879 RmuC family; Region: RmuC; pfam02646 1091494010880 AAA domain; Region: AAA_30; pfam13604 1091494010881 Family description; Region: UvrD_C_2; pfam13538 1091494010882 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1091494010883 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1091494010884 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1091494010885 Family description; Region: UvrD_C_2; pfam13538 1091494010886 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1091494010887 Sporulation related domain; Region: SPOR; pfam05036 1091494010888 FtsH Extracellular; Region: FtsH_ext; pfam06480 1091494010889 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1091494010890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494010891 Walker A motif; other site 1091494010892 ATP binding site [chemical binding]; other site 1091494010893 Walker B motif; other site 1091494010894 arginine finger; other site 1091494010895 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091494010896 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1091494010897 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1091494010898 5'-nucleotidase; Provisional; Region: PRK03826 1091494010899 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1091494010900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091494010901 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1091494010902 active site 1091494010903 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1091494010904 active sites [active] 1091494010905 tetramer interface [polypeptide binding]; other site 1091494010906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494010907 putative active site [active] 1091494010908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1091494010909 putative acyl-acceptor binding pocket; other site 1091494010910 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1091494010911 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1091494010912 Ligand binding site; other site 1091494010913 Putative Catalytic site; other site 1091494010914 DXD motif; other site 1091494010915 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1091494010916 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1091494010917 acyl-activating enzyme (AAE) consensus motif; other site 1091494010918 AMP binding site [chemical binding]; other site 1091494010919 active site 1091494010920 CoA binding site [chemical binding]; other site 1091494010921 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1091494010922 active site 2 [active] 1091494010923 dimer interface [polypeptide binding]; other site 1091494010924 active site 1 [active] 1091494010925 Predicted membrane protein [Function unknown]; Region: COG4648 1091494010926 acyl carrier protein; Provisional; Region: PRK05350 1091494010927 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1091494010928 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1091494010929 hypothetical protein; Provisional; Region: PRK11820 1091494010930 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1091494010931 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1091494010932 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1091494010933 active site 1091494010934 ATP binding site [chemical binding]; other site 1091494010935 substrate binding site [chemical binding]; other site 1091494010936 activation loop (A-loop); other site 1091494010937 ribonuclease PH; Reviewed; Region: rph; PRK00173 1091494010938 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1091494010939 hexamer interface [polypeptide binding]; other site 1091494010940 active site 1091494010941 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1091494010942 active site 1091494010943 dimerization interface [polypeptide binding]; other site 1091494010944 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1091494010945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091494010946 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1091494010947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091494010948 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1091494010949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091494010950 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1091494010951 ferrochelatase; Reviewed; Region: hemH; PRK00035 1091494010952 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1091494010953 C-terminal domain interface [polypeptide binding]; other site 1091494010954 active site 1091494010955 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1091494010956 active site 1091494010957 N-terminal domain interface [polypeptide binding]; other site 1091494010958 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1091494010959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494010960 N-terminal plug; other site 1091494010961 ligand-binding site [chemical binding]; other site 1091494010962 Predicted membrane protein [Function unknown]; Region: COG3212 1091494010963 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1091494010964 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1091494010965 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1091494010966 VacJ like lipoprotein; Region: VacJ; cl01073 1091494010967 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1091494010968 Sodium Bile acid symporter family; Region: SBF; pfam01758 1091494010969 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1091494010970 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494010971 active site 1091494010972 Cytochrome c; Region: Cytochrom_C; pfam00034 1091494010973 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1091494010974 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1091494010975 AMMECR1; Region: AMMECR1; pfam01871 1091494010976 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1091494010977 putative ligand binding pocket/active site [active] 1091494010978 putative metal binding site [ion binding]; other site 1091494010979 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1091494010980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1091494010981 FeS/SAM binding site; other site 1091494010982 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494010983 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1091494010984 FtsX-like permease family; Region: FtsX; pfam02687 1091494010985 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494010986 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1091494010987 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1091494010988 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1091494010989 hypothetical protein; Validated; Region: PRK00124 1091494010990 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1091494010991 Part of AAA domain; Region: AAA_19; pfam13245 1091494010992 Family description; Region: UvrD_C_2; pfam13538 1091494010993 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1091494010994 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1091494010995 putative active site [active] 1091494010996 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1091494010997 Putative addiction module component; Region: Unstab_antitox; pfam09720 1091494010998 Predicted membrane protein [Function unknown]; Region: COG4648 1091494010999 Predicted exporter [General function prediction only]; Region: COG4258 1091494011000 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1091494011001 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1091494011002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011003 S-adenosylmethionine binding site [chemical binding]; other site 1091494011004 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1091494011005 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1091494011006 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494011007 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1091494011008 Protein of unknown function DUF91; Region: DUF91; cl00709 1091494011009 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 1091494011010 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1091494011011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1091494011012 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1091494011013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1091494011014 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1091494011015 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1091494011016 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1091494011017 Fic family protein [Function unknown]; Region: COG3177 1091494011018 Fic/DOC family; Region: Fic; pfam02661 1091494011019 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 1091494011020 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1091494011021 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1091494011022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494011023 ATP binding site [chemical binding]; other site 1091494011024 putative Mg++ binding site [ion binding]; other site 1091494011025 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1091494011026 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091494011027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494011028 dimerization interface [polypeptide binding]; other site 1091494011029 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1091494011030 GAF domain; Region: GAF; pfam01590 1091494011031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1091494011033 putative active site [active] 1091494011034 heme pocket [chemical binding]; other site 1091494011035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494011036 dimer interface [polypeptide binding]; other site 1091494011037 phosphorylation site [posttranslational modification] 1091494011038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494011039 ATP binding site [chemical binding]; other site 1091494011040 Mg2+ binding site [ion binding]; other site 1091494011041 G-X-G motif; other site 1091494011042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011043 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494011044 active site 1091494011045 phosphorylation site [posttranslational modification] 1091494011046 intermolecular recognition site; other site 1091494011047 dimerization interface [polypeptide binding]; other site 1091494011048 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1091494011049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011050 active site 1091494011051 phosphorylation site [posttranslational modification] 1091494011052 intermolecular recognition site; other site 1091494011053 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494011054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011055 active site 1091494011056 phosphorylation site [posttranslational modification] 1091494011057 intermolecular recognition site; other site 1091494011058 dimerization interface [polypeptide binding]; other site 1091494011059 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494011060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011061 active site 1091494011062 phosphorylation site [posttranslational modification] 1091494011063 intermolecular recognition site; other site 1091494011064 dimerization interface [polypeptide binding]; other site 1091494011065 GAF domain; Region: GAF_2; pfam13185 1091494011066 GAF domain; Region: GAF; pfam01590 1091494011067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494011068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011069 metal binding site [ion binding]; metal-binding site 1091494011070 active site 1091494011071 I-site; other site 1091494011072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494011073 Response regulator receiver domain; Region: Response_reg; pfam00072 1091494011074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011075 active site 1091494011076 phosphorylation site [posttranslational modification] 1091494011077 intermolecular recognition site; other site 1091494011078 dimerization interface [polypeptide binding]; other site 1091494011079 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 1091494011080 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1091494011081 Sel1-like repeats; Region: SEL1; smart00671 1091494011082 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1091494011083 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1091494011084 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1091494011085 catalytic residue [active] 1091494011086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011087 metal binding site [ion binding]; metal-binding site 1091494011088 active site 1091494011089 I-site; other site 1091494011090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494011091 Predicted transglutaminase-like cysteine proteinase [General function prediction only]; Region: COG3672 1091494011092 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1091494011093 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1091494011094 metal ion-dependent adhesion site (MIDAS); other site 1091494011095 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1091494011096 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1091494011097 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1091494011098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1091494011099 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1091494011100 Walker A/P-loop; other site 1091494011101 ATP binding site [chemical binding]; other site 1091494011102 Q-loop/lid; other site 1091494011103 ABC transporter signature motif; other site 1091494011104 Walker B; other site 1091494011105 D-loop; other site 1091494011106 H-loop/switch region; other site 1091494011107 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1091494011108 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494011109 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494011110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1091494011111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494011112 DNA binding residues [nucleotide binding] 1091494011113 dimerization interface [polypeptide binding]; other site 1091494011114 transposase; Provisional; Region: PRK06526 1091494011115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494011116 Walker A motif; other site 1091494011117 ATP binding site [chemical binding]; other site 1091494011118 Walker B motif; other site 1091494011119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1091494011120 DNA binding residues [nucleotide binding] 1091494011121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1091494011122 Integrase core domain; Region: rve; pfam00665 1091494011123 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1091494011124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494011126 binding surface 1091494011127 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494011128 TPR motif; other site 1091494011129 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1091494011130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1091494011131 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1091494011132 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1091494011133 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1091494011134 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1091494011135 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494011136 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494011137 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1091494011138 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1091494011139 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1091494011140 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1091494011141 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1091494011142 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1091494011143 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1091494011144 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1091494011145 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 1091494011146 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 1091494011147 helicase Cas3; Provisional; Region: PRK09694 1091494011148 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1091494011149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1091494011150 Predicted transcriptional regulator [Transcription]; Region: COG2378 1091494011151 WYL domain; Region: WYL; pfam13280 1091494011152 PAS domain S-box; Region: sensory_box; TIGR00229 1091494011153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011154 putative active site [active] 1091494011155 heme pocket [chemical binding]; other site 1091494011156 PAS fold; Region: PAS_3; pfam08447 1091494011157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011158 heme pocket [chemical binding]; other site 1091494011159 putative active site [active] 1091494011160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011161 PAS domain; Region: PAS_9; pfam13426 1091494011162 putative active site [active] 1091494011163 heme pocket [chemical binding]; other site 1091494011164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494011165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011166 metal binding site [ion binding]; metal-binding site 1091494011167 active site 1091494011168 I-site; other site 1091494011169 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494011170 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1091494011171 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 1091494011172 nickel binding site [ion binding]; other site 1091494011173 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1091494011174 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1091494011175 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1091494011176 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1091494011177 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1091494011178 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1091494011179 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1091494011180 active site 1091494011181 catalytic triad [active] 1091494011182 oxyanion hole [active] 1091494011183 switch loop; other site 1091494011184 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1091494011185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494011186 Walker A/P-loop; other site 1091494011187 ATP binding site [chemical binding]; other site 1091494011188 Q-loop/lid; other site 1091494011189 ABC transporter signature motif; other site 1091494011190 Walker B; other site 1091494011191 D-loop; other site 1091494011192 H-loop/switch region; other site 1091494011193 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1091494011194 FtsX-like permease family; Region: FtsX; pfam02687 1091494011195 FtsX-like permease family; Region: FtsX; pfam02687 1091494011196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011197 PAS fold; Region: PAS_3; pfam08447 1091494011198 putative active site [active] 1091494011199 heme pocket [chemical binding]; other site 1091494011200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494011201 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494011202 dimer interface [polypeptide binding]; other site 1091494011203 putative CheW interface [polypeptide binding]; other site 1091494011204 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1091494011205 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 1091494011206 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494011207 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1091494011208 alpha subunit interaction interface [polypeptide binding]; other site 1091494011209 Walker A motif; other site 1091494011210 ATP binding site [chemical binding]; other site 1091494011211 Walker B motif; other site 1091494011212 inhibitor binding site; inhibition site 1091494011213 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091494011214 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 1091494011215 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1091494011216 gamma subunit interface [polypeptide binding]; other site 1091494011217 epsilon subunit interface [polypeptide binding]; other site 1091494011218 LBP interface [polypeptide binding]; other site 1091494011219 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1091494011220 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 1091494011221 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1091494011222 alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306 1091494011223 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1091494011224 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 1091494011225 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1091494011226 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 1091494011227 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1091494011228 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1091494011229 beta subunit interaction interface [polypeptide binding]; other site 1091494011230 Walker A motif; other site 1091494011231 ATP binding site [chemical binding]; other site 1091494011232 Walker B motif; other site 1091494011233 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1091494011234 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1091494011235 core domain interface [polypeptide binding]; other site 1091494011236 delta subunit interface [polypeptide binding]; other site 1091494011237 epsilon subunit interface [polypeptide binding]; other site 1091494011238 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494011239 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494011240 Integrase core domain; Region: rve; pfam00665 1091494011241 Integrase core domain; Region: rve_3; pfam13683 1091494011242 Transposase; Region: HTH_Tnp_1; cl17663 1091494011243 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1091494011244 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1091494011245 nucleoside/Zn binding site; other site 1091494011246 dimer interface [polypeptide binding]; other site 1091494011247 catalytic motif [active] 1091494011248 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1091494011249 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1091494011250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1091494011251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1091494011252 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1091494011253 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1091494011254 FMN binding site [chemical binding]; other site 1091494011255 active site 1091494011256 substrate binding site [chemical binding]; other site 1091494011257 catalytic residue [active] 1091494011258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011259 PAS fold; Region: PAS_3; pfam08447 1091494011260 putative active site [active] 1091494011261 heme pocket [chemical binding]; other site 1091494011262 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1091494011263 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1091494011264 dimer interface [polypeptide binding]; other site 1091494011265 putative CheW interface [polypeptide binding]; other site 1091494011266 AAA domain; Region: AAA_32; pfam13654 1091494011267 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1091494011268 PAS domain; Region: PAS; smart00091 1091494011269 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1091494011270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494011271 Walker A motif; other site 1091494011272 ATP binding site [chemical binding]; other site 1091494011273 Walker B motif; other site 1091494011274 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1091494011275 HDOD domain; Region: HDOD; pfam08668 1091494011276 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1091494011277 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1091494011278 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1091494011279 antiporter inner membrane protein; Provisional; Region: PRK11670 1091494011280 Domain of unknown function DUF59; Region: DUF59; pfam01883 1091494011281 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1091494011282 Walker A motif; other site 1091494011283 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1091494011284 trimer interface [polypeptide binding]; other site 1091494011285 active site 1091494011286 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1091494011287 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1091494011288 Walker A/P-loop; other site 1091494011289 ATP binding site [chemical binding]; other site 1091494011290 Q-loop/lid; other site 1091494011291 ABC transporter signature motif; other site 1091494011292 Walker B; other site 1091494011293 D-loop; other site 1091494011294 H-loop/switch region; other site 1091494011295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1091494011296 ABC-ATPase subunit interface; other site 1091494011297 dimer interface [polypeptide binding]; other site 1091494011298 putative PBP binding regions; other site 1091494011299 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1091494011300 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1091494011301 putative hemin binding site; other site 1091494011302 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1091494011303 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1091494011304 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1091494011305 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1091494011306 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1091494011307 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1091494011308 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1091494011309 Kelch motif; Region: Kelch_1; pfam01344 1091494011310 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1091494011311 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1091494011312 N-terminal plug; other site 1091494011313 ligand-binding site [chemical binding]; other site 1091494011314 Reovirus core-spike protein lambda-2 (L2); Region: Reovirus_L2; pfam06016 1091494011315 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1091494011316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1091494011317 DNA binding residues [nucleotide binding] 1091494011318 dimerization interface [polypeptide binding]; other site 1091494011319 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1091494011320 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1091494011321 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1091494011322 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1091494011323 Probable Catalytic site; other site 1091494011324 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1091494011325 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494011326 active site 1091494011327 Int/Topo IB signature motif; other site 1091494011328 DNA binding site [nucleotide binding] 1091494011329 SWIM zinc finger; Region: SWIM; pfam04434 1091494011330 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1091494011331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1091494011332 ATP binding site [chemical binding]; other site 1091494011333 putative Mg++ binding site [ion binding]; other site 1091494011334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494011335 nucleotide binding region [chemical binding]; other site 1091494011336 ATP-binding site [chemical binding]; other site 1091494011337 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 1091494011338 integrase; Provisional; Region: int; PHA02601 1091494011339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1091494011340 active site 1091494011341 DNA binding site [nucleotide binding] 1091494011342 Int/Topo IB signature motif; other site 1091494011343 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1091494011344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1091494011345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1091494011346 active site 1091494011347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011348 S-adenosylmethionine binding site [chemical binding]; other site 1091494011349 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1091494011350 intersubunit interface [polypeptide binding]; other site 1091494011351 active site 1091494011352 zinc binding site [ion binding]; other site 1091494011353 Na+ binding site [ion binding]; other site 1091494011354 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1091494011355 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 1091494011356 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1091494011357 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1091494011358 Transposase IS200 like; Region: Y1_Tnp; cl00848 1091494011359 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1091494011360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1091494011361 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1091494011362 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1091494011363 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1091494011364 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1091494011365 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1091494011366 Flavodoxin; Region: Flavodoxin_1; pfam00258 1091494011367 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1091494011368 FAD binding pocket [chemical binding]; other site 1091494011369 FAD binding motif [chemical binding]; other site 1091494011370 catalytic residues [active] 1091494011371 NAD binding pocket [chemical binding]; other site 1091494011372 phosphate binding motif [ion binding]; other site 1091494011373 beta-alpha-beta structure motif; other site 1091494011374 sulfite reductase subunit beta; Provisional; Region: PRK13504 1091494011375 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091494011376 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1091494011377 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1091494011378 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1091494011379 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1091494011380 active site 1091494011381 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1091494011382 putative active site [active] 1091494011383 putative metal binding site [ion binding]; other site 1091494011384 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1091494011385 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1091494011386 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1091494011387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011388 PAS fold; Region: PAS_3; pfam08447 1091494011389 putative active site [active] 1091494011390 heme pocket [chemical binding]; other site 1091494011391 PAS domain; Region: PAS_9; pfam13426 1091494011392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494011393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011394 metal binding site [ion binding]; metal-binding site 1091494011395 active site 1091494011396 I-site; other site 1091494011397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494011398 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1091494011399 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1091494011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1091494011401 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1091494011402 mce related protein; Region: MCE; pfam02470 1091494011403 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1091494011404 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1091494011405 Walker A/P-loop; other site 1091494011406 ATP binding site [chemical binding]; other site 1091494011407 Q-loop/lid; other site 1091494011408 ABC transporter signature motif; other site 1091494011409 Walker B; other site 1091494011410 D-loop; other site 1091494011411 H-loop/switch region; other site 1091494011412 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1091494011413 Permease; Region: Permease; pfam02405 1091494011414 Cytochrome c [Energy production and conversion]; Region: COG3258 1091494011415 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1091494011416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1091494011417 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1091494011418 active site 1091494011419 metal binding site [ion binding]; metal-binding site 1091494011420 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1091494011421 PAS domain S-box; Region: sensory_box; TIGR00229 1091494011422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011423 putative active site [active] 1091494011424 heme pocket [chemical binding]; other site 1091494011425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011426 PAS domain; Region: PAS_9; pfam13426 1091494011427 putative active site [active] 1091494011428 heme pocket [chemical binding]; other site 1091494011429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494011430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011431 metal binding site [ion binding]; metal-binding site 1091494011432 active site 1091494011433 I-site; other site 1091494011434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1091494011435 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1091494011436 CheB methylesterase; Region: CheB_methylest; pfam01339 1091494011437 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1091494011438 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1091494011439 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1091494011440 PAS domain; Region: PAS_10; pfam13596 1091494011441 PAS domain S-box; Region: sensory_box; TIGR00229 1091494011442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011443 putative active site [active] 1091494011444 heme pocket [chemical binding]; other site 1091494011445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1091494011446 PAS domain; Region: PAS_9; pfam13426 1091494011447 putative active site [active] 1091494011448 heme pocket [chemical binding]; other site 1091494011449 Asparaginase; Region: Asparaginase; pfam00710 1091494011450 active site 1091494011451 homodimer interface [polypeptide binding]; other site 1091494011452 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1091494011453 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1091494011454 NADP+ binding site [chemical binding]; other site 1091494011455 folate binding site [chemical binding]; other site 1091494011456 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1091494011457 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1091494011458 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1091494011459 Divergent AAA domain; Region: AAA_4; pfam04326 1091494011460 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1091494011461 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1091494011462 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1091494011463 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1091494011464 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1091494011465 active site 1091494011466 metal binding site [ion binding]; metal-binding site 1091494011467 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1091494011468 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1091494011469 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1091494011470 Transposase; Region: HTH_Tnp_1; cl17663 1091494011471 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494011472 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494011473 Integrase core domain; Region: rve; pfam00665 1091494011474 Integrase core domain; Region: rve_3; pfam13683 1091494011475 isocitrate dehydrogenase; Validated; Region: PRK08299 1091494011476 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494011477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1091494011478 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494011479 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091494011480 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494011481 Walker A/P-loop; other site 1091494011482 ATP binding site [chemical binding]; other site 1091494011483 Q-loop/lid; other site 1091494011484 ABC transporter signature motif; other site 1091494011485 Walker B; other site 1091494011486 D-loop; other site 1091494011487 H-loop/switch region; other site 1091494011488 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1091494011489 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1091494011490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011491 active site 1091494011492 phosphorylation site [posttranslational modification] 1091494011493 intermolecular recognition site; other site 1091494011494 dimerization interface [polypeptide binding]; other site 1091494011495 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1091494011496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011497 active site 1091494011498 phosphorylation site [posttranslational modification] 1091494011499 intermolecular recognition site; other site 1091494011500 dimerization interface [polypeptide binding]; other site 1091494011501 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1091494011502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1091494011503 dimerization interface [polypeptide binding]; other site 1091494011504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494011505 dimer interface [polypeptide binding]; other site 1091494011506 phosphorylation site [posttranslational modification] 1091494011507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494011508 ATP binding site [chemical binding]; other site 1091494011509 Mg2+ binding site [ion binding]; other site 1091494011510 G-X-G motif; other site 1091494011511 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1091494011512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011513 active site 1091494011514 phosphorylation site [posttranslational modification] 1091494011515 intermolecular recognition site; other site 1091494011516 dimerization interface [polypeptide binding]; other site 1091494011517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494011518 DNA binding site [nucleotide binding] 1091494011519 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494011520 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494011521 Integrase core domain; Region: rve; pfam00665 1091494011522 Integrase core domain; Region: rve_3; pfam13683 1091494011523 Transposase; Region: HTH_Tnp_1; cl17663 1091494011524 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1091494011525 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1091494011526 putative active site [active] 1091494011527 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1091494011528 Peptidase family M28; Region: Peptidase_M28; pfam04389 1091494011529 metal binding site [ion binding]; metal-binding site 1091494011530 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1091494011531 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 1091494011532 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1091494011533 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 1091494011534 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1091494011535 translocation protein TolB; Provisional; Region: tolB; PRK01742 1091494011536 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1091494011537 Carbon starvation protein CstA; Region: CstA; pfam02554 1091494011538 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1091494011539 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091494011540 DTAP/Switch II; other site 1091494011541 Switch I; other site 1091494011542 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1091494011543 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 1091494011544 DNA ligase; Provisional; Region: PRK09125 1091494011545 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1091494011546 DNA binding site [nucleotide binding] 1091494011547 active site 1091494011548 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1091494011549 DNA binding site [nucleotide binding] 1091494011550 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1091494011551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1091494011552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1091494011553 metal binding site [ion binding]; metal-binding site 1091494011554 active site 1091494011555 I-site; other site 1091494011556 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1091494011557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011558 S-adenosylmethionine binding site [chemical binding]; other site 1091494011559 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1091494011560 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 1091494011561 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1091494011562 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1091494011563 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1091494011564 aminopeptidase N; Provisional; Region: pepN; PRK14015 1091494011565 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1091494011566 active site 1091494011567 Zn binding site [ion binding]; other site 1091494011568 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1091494011569 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1091494011570 MPT binding site; other site 1091494011571 trimer interface [polypeptide binding]; other site 1091494011572 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1091494011573 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1091494011574 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494011575 protein binding site [polypeptide binding]; other site 1091494011576 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1091494011577 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1091494011578 ligand binding site [chemical binding]; other site 1091494011579 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1091494011580 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494011581 ligand binding site [chemical binding]; other site 1091494011582 flexible hinge region; other site 1091494011583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1091494011584 active site residue [active] 1091494011585 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1091494011586 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1091494011587 glutathione synthetase; Provisional; Region: PRK05246 1091494011588 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1091494011589 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1091494011590 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1091494011591 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1091494011592 hypothetical protein; Validated; Region: PRK00228 1091494011593 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1091494011594 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1091494011595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1091494011596 active site 1091494011597 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1091494011598 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1091494011599 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1091494011600 dihydroorotase; Validated; Region: pyrC; PRK09357 1091494011601 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1091494011602 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1091494011603 active site 1091494011604 Cytochrome c; Region: Cytochrom_C; cl11414 1091494011605 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1091494011606 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1091494011607 FAD binding domain; Region: FAD_binding_4; pfam01565 1091494011608 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1091494011609 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1091494011610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1091494011611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1091494011612 dimer interface [polypeptide binding]; other site 1091494011613 phosphorylation site [posttranslational modification] 1091494011614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1091494011615 ATP binding site [chemical binding]; other site 1091494011616 Mg2+ binding site [ion binding]; other site 1091494011617 G-X-G motif; other site 1091494011618 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1091494011619 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1091494011620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011621 S-adenosylmethionine binding site [chemical binding]; other site 1091494011622 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 1091494011623 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1091494011624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011625 S-adenosylmethionine binding site [chemical binding]; other site 1091494011626 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1091494011627 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1091494011628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1091494011629 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1091494011630 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1091494011631 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1091494011632 Di-iron ligands [ion binding]; other site 1091494011633 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1091494011634 SnoaL-like domain; Region: SnoaL_2; pfam12680 1091494011635 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1091494011636 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1091494011637 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1091494011638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1091494011639 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1091494011640 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1091494011641 PemK-like protein; Region: PemK; pfam02452 1091494011642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1091494011643 S-adenosylmethionine binding site [chemical binding]; other site 1091494011644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1091494011645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1091494011646 active site 1091494011647 phosphorylation site [posttranslational modification] 1091494011648 intermolecular recognition site; other site 1091494011649 dimerization interface [polypeptide binding]; other site 1091494011650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1091494011651 DNA binding site [nucleotide binding] 1091494011652 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 1091494011653 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1091494011654 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1091494011655 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1091494011656 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1091494011657 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1091494011658 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1091494011659 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1091494011660 short chain dehydrogenase; Provisional; Region: PRK07577 1091494011661 classical (c) SDRs; Region: SDR_c; cd05233 1091494011662 NAD(P) binding site [chemical binding]; other site 1091494011663 active site 1091494011664 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1091494011665 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1091494011666 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1091494011667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1091494011668 non-specific DNA binding site [nucleotide binding]; other site 1091494011669 salt bridge; other site 1091494011670 sequence-specific DNA binding site [nucleotide binding]; other site 1091494011671 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1091494011672 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1091494011673 ferredoxin; Provisional; Region: PRK08764 1091494011674 Putative Fe-S cluster; Region: FeS; cl17515 1091494011675 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091494011676 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1091494011677 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1091494011678 FAD binding pocket [chemical binding]; other site 1091494011679 conserved FAD binding motif [chemical binding]; other site 1091494011680 phosphate binding motif [ion binding]; other site 1091494011681 beta-alpha-beta structure motif; other site 1091494011682 NAD binding pocket [chemical binding]; other site 1091494011683 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1091494011684 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1091494011685 FMN-binding domain; Region: FMN_bind; cl01081 1091494011686 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1091494011687 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1091494011688 SLBB domain; Region: SLBB; pfam10531 1091494011689 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1091494011690 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 1091494011691 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1091494011692 dimer interface [polypeptide binding]; other site 1091494011693 PYR/PP interface [polypeptide binding]; other site 1091494011694 TPP binding site [chemical binding]; other site 1091494011695 substrate binding site [chemical binding]; other site 1091494011696 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1091494011697 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 1091494011698 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1091494011699 4Fe-4S binding domain; Region: Fer4; pfam00037 1091494011700 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1091494011701 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1091494011702 TPP-binding site [chemical binding]; other site 1091494011703 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1091494011704 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1091494011705 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 1091494011706 Na binding site [ion binding]; other site 1091494011707 putative glycosylation site [posttranslational modification]; other site 1091494011708 putative glycosylation site [posttranslational modification]; other site 1091494011709 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1091494011710 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1091494011711 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1091494011712 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1091494011713 metal-binding site [ion binding] 1091494011714 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1091494011715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494011716 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1091494011717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1091494011718 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1091494011719 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1091494011720 active site residue [active] 1091494011721 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1091494011722 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1091494011723 active site 1091494011724 intersubunit interface [polypeptide binding]; other site 1091494011725 zinc binding site [ion binding]; other site 1091494011726 Na+ binding site [ion binding]; other site 1091494011727 transaldolase-like protein; Provisional; Region: PTZ00411 1091494011728 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1091494011729 active site 1091494011730 dimer interface [polypeptide binding]; other site 1091494011731 catalytic residue [active] 1091494011732 transketolase; Reviewed; Region: PRK12753 1091494011733 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1091494011734 TPP-binding site [chemical binding]; other site 1091494011735 dimer interface [polypeptide binding]; other site 1091494011736 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1091494011737 PYR/PP interface [polypeptide binding]; other site 1091494011738 dimer interface [polypeptide binding]; other site 1091494011739 TPP binding site [chemical binding]; other site 1091494011740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1091494011741 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1091494011742 tetramer interface [polypeptide binding]; other site 1091494011743 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1091494011744 active site 1091494011745 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1091494011746 active site 1091494011747 dimer interface [polypeptide binding]; other site 1091494011748 magnesium binding site [ion binding]; other site 1091494011749 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1091494011750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494011751 active site 1091494011752 motif I; other site 1091494011753 motif II; other site 1091494011754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1091494011755 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1091494011756 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1091494011757 DAK2 domain; Region: Dak2; cl03685 1091494011758 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1091494011759 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1091494011760 dimer interface [polypeptide binding]; other site 1091494011761 ADP-ribose binding site [chemical binding]; other site 1091494011762 active site 1091494011763 nudix motif; other site 1091494011764 metal binding site [ion binding]; metal-binding site 1091494011765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1091494011766 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1091494011767 motif II; other site 1091494011768 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1091494011769 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1091494011770 ATP binding site [chemical binding]; other site 1091494011771 Mg++ binding site [ion binding]; other site 1091494011772 motif III; other site 1091494011773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1091494011774 nucleotide binding region [chemical binding]; other site 1091494011775 ATP-binding site [chemical binding]; other site 1091494011776 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1091494011777 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1091494011778 catalytic residues [active] 1091494011779 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1091494011780 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1091494011781 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1091494011782 RNA binding site [nucleotide binding]; other site 1091494011783 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1091494011784 multimer interface [polypeptide binding]; other site 1091494011785 Walker A motif; other site 1091494011786 ATP binding site [chemical binding]; other site 1091494011787 Walker B motif; other site 1091494011788 oxidative damage protection protein; Provisional; Region: PRK05408 1091494011789 adenine DNA glycosylase; Provisional; Region: PRK10880 1091494011790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1091494011791 minor groove reading motif; other site 1091494011792 helix-hairpin-helix signature motif; other site 1091494011793 substrate binding pocket [chemical binding]; other site 1091494011794 active site 1091494011795 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1091494011796 DNA binding and oxoG recognition site [nucleotide binding] 1091494011797 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1091494011798 Rubredoxin; Region: Rubredoxin; pfam00301 1091494011799 iron binding site [ion binding]; other site 1091494011800 AsmA family; Region: AsmA; pfam05170 1091494011801 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1091494011802 peroxidase; Provisional; Region: PRK15000 1091494011803 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1091494011804 dimer interface [polypeptide binding]; other site 1091494011805 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1091494011806 catalytic triad [active] 1091494011807 peroxidatic and resolving cysteines [active] 1091494011808 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1091494011809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494011810 binding surface 1091494011811 TPR motif; other site 1091494011812 TPR repeat; Region: TPR_11; pfam13414 1091494011813 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1091494011814 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1091494011815 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494011816 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1091494011817 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494011818 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1091494011819 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1091494011820 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1091494011821 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1091494011822 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1091494011823 metal binding site [ion binding]; metal-binding site 1091494011824 dimer interface [polypeptide binding]; other site 1091494011825 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1091494011826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1091494011827 inhibitor-cofactor binding pocket; inhibition site 1091494011828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1091494011829 catalytic residue [active] 1091494011830 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1091494011831 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1091494011832 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1091494011833 active site 1091494011834 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1091494011835 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1091494011836 NAD(P) binding site [chemical binding]; other site 1091494011837 catalytic residues [active] 1091494011838 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1091494011839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1091494011840 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1091494011841 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1091494011842 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1091494011843 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1091494011844 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1091494011845 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1091494011846 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1091494011847 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1091494011848 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1091494011849 Winged helix-turn helix; Region: HTH_29; pfam13551 1091494011850 Homeodomain-like domain; Region: HTH_32; pfam13565 1091494011851 Integrase core domain; Region: rve; pfam00665 1091494011852 Integrase core domain; Region: rve_3; pfam13683 1091494011853 Transposase; Region: HTH_Tnp_1; cl17663 1091494011854 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1091494011855 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1091494011856 substrate binding site [chemical binding]; other site 1091494011857 hexamer interface [polypeptide binding]; other site 1091494011858 metal binding site [ion binding]; metal-binding site 1091494011859 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1091494011860 putative homodimer interface [polypeptide binding]; other site 1091494011861 putative active site pocket [active] 1091494011862 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1091494011863 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1091494011864 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1091494011865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1091494011866 Divalent cation transporter; Region: MgtE; cl00786 1091494011867 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1091494011868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1091494011869 DNA binding residues [nucleotide binding] 1091494011870 B12 binding domain; Region: B12-binding_2; pfam02607 1091494011871 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1091494011872 B12 binding site [chemical binding]; other site 1091494011873 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1091494011874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1091494011875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1091494011876 DNA binding residues [nucleotide binding] 1091494011877 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1091494011878 HflK protein; Region: hflK; TIGR01933 1091494011879 FtsH protease regulator HflC; Provisional; Region: PRK11029 1091494011880 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1091494011881 FtsH Extracellular; Region: FtsH_ext; pfam06480 1091494011882 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1091494011883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494011884 Walker A motif; other site 1091494011885 ATP binding site [chemical binding]; other site 1091494011886 Walker B motif; other site 1091494011887 arginine finger; other site 1091494011888 Peptidase family M41; Region: Peptidase_M41; pfam01434 1091494011889 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1091494011890 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1091494011891 putative NAD(P) binding site [chemical binding]; other site 1091494011892 putative active site [active] 1091494011893 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1091494011894 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1091494011895 active site 1091494011896 HIGH motif; other site 1091494011897 KMSKS motif; other site 1091494011898 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1091494011899 anticodon binding site; other site 1091494011900 tRNA binding surface [nucleotide binding]; other site 1091494011901 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1091494011902 dimer interface [polypeptide binding]; other site 1091494011903 putative tRNA-binding site [nucleotide binding]; other site 1091494011904 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1091494011905 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1091494011906 HlyD family secretion protein; Region: HlyD_3; pfam13437 1091494011907 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1091494011908 FtsX-like permease family; Region: FtsX; pfam02687 1091494011909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1091494011910 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1091494011911 FtsX-like permease family; Region: FtsX; pfam02687 1091494011912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1091494011913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1091494011914 Walker A/P-loop; other site 1091494011915 ATP binding site [chemical binding]; other site 1091494011916 Q-loop/lid; other site 1091494011917 ABC transporter signature motif; other site 1091494011918 Walker B; other site 1091494011919 D-loop; other site 1091494011920 H-loop/switch region; other site 1091494011921 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1091494011922 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1091494011923 substrate binding site [chemical binding]; other site 1091494011924 ATP binding site [chemical binding]; other site 1091494011925 Predicted solute binding protein [General function prediction only]; Region: COG3889 1091494011926 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1091494011927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1091494011928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494011929 dimer interface [polypeptide binding]; other site 1091494011930 conserved gate region; other site 1091494011931 putative PBP binding loops; other site 1091494011932 ABC-ATPase subunit interface; other site 1091494011933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1091494011934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1091494011935 dimer interface [polypeptide binding]; other site 1091494011936 conserved gate region; other site 1091494011937 putative PBP binding loops; other site 1091494011938 ABC-ATPase subunit interface; other site 1091494011939 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1091494011940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091494011941 Walker A/P-loop; other site 1091494011942 ATP binding site [chemical binding]; other site 1091494011943 Q-loop/lid; other site 1091494011944 ABC transporter signature motif; other site 1091494011945 Walker B; other site 1091494011946 D-loop; other site 1091494011947 H-loop/switch region; other site 1091494011948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091494011949 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1091494011950 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1091494011951 Walker A/P-loop; other site 1091494011952 ATP binding site [chemical binding]; other site 1091494011953 Q-loop/lid; other site 1091494011954 ABC transporter signature motif; other site 1091494011955 Walker B; other site 1091494011956 D-loop; other site 1091494011957 H-loop/switch region; other site 1091494011958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1091494011959 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1091494011960 putative substrate binding pocket [chemical binding]; other site 1091494011961 AC domain interface; other site 1091494011962 catalytic triad [active] 1091494011963 AB domain interface; other site 1091494011964 interchain disulfide; other site 1091494011965 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1091494011966 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1091494011967 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1091494011968 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1091494011969 putative catalytic residue [active] 1091494011970 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1091494011971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1091494011972 ligand binding site [chemical binding]; other site 1091494011973 flexible hinge region; other site 1091494011974 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1091494011975 putative switch regulator; other site 1091494011976 non-specific DNA interactions [nucleotide binding]; other site 1091494011977 DNA binding site [nucleotide binding] 1091494011978 sequence specific DNA binding site [nucleotide binding]; other site 1091494011979 putative cAMP binding site [chemical binding]; other site 1091494011980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1091494011981 dimerization interface [polypeptide binding]; other site 1091494011982 putative DNA binding site [nucleotide binding]; other site 1091494011983 putative Zn2+ binding site [ion binding]; other site 1091494011984 Oxygen tolerance; Region: BatD; pfam13584 1091494011985 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1091494011986 metal ion-dependent adhesion site (MIDAS); other site 1091494011987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1091494011988 binding surface 1091494011989 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1091494011990 TPR motif; other site 1091494011991 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1091494011992 metal ion-dependent adhesion site (MIDAS); other site 1091494011993 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1091494011994 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1091494011995 Protein of unknown function DUF58; Region: DUF58; pfam01882 1091494011996 MoxR-like ATPases [General function prediction only]; Region: COG0714 1091494011997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1091494011998 Walker A motif; other site 1091494011999 ATP binding site [chemical binding]; other site 1091494012000 Walker B motif; other site 1091494012001 arginine finger; other site 1091494012002 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1091494012003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1091494012004 putative substrate translocation pore; other site 1091494012005 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1091494012006 short chain dehydrogenase; Provisional; Region: PRK05993 1091494012007 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1091494012008 NADP binding site [chemical binding]; other site 1091494012009 active site 1091494012010 steroid binding site; other site 1091494012011 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1091494012012 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1091494012013 HNH endonuclease; Region: HNH_3; pfam13392 1091494012014 AP2 domain; Region: AP2; pfam00847 1091494012015 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1091494012016 YcfA-like protein; Region: YcfA; cl00752 1091494012017 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1091494012018 integrase; Provisional; Region: PRK09692 1091494012019 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1091494012020 active site 1091494012021 Int/Topo IB signature motif; other site 1091494012022 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1091494012023 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1091494012024 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1091494012025 G1 box; other site 1091494012026 GTP/Mg2+ binding site [chemical binding]; other site 1091494012027 Switch I region; other site 1091494012028 G2 box; other site 1091494012029 Switch II region; other site 1091494012030 G3 box; other site 1091494012031 G4 box; other site 1091494012032 G5 box; other site 1091494012033 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1091494012034 membrane protein insertase; Provisional; Region: PRK01318 1091494012035 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1091494012036 Ribonuclease P; Region: Ribonuclease_P; cl00457