-- dump date   	20140619_145117
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
857087000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
857087000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
857087000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000004	Walker A motif; other site
857087000005	ATP binding site [chemical binding]; other site
857087000006	Walker B motif; other site
857087000007	arginine finger; other site
857087000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
857087000009	DnaA box-binding interface [nucleotide binding]; other site
857087000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
857087000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
857087000012	putative DNA binding surface [nucleotide binding]; other site
857087000013	dimer interface [polypeptide binding]; other site
857087000014	beta-clamp/clamp loader binding surface; other site
857087000015	beta-clamp/translesion DNA polymerase binding surface; other site
857087000016	recombination protein F; Reviewed; Region: recF; PRK00064
857087000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087000018	Walker A/P-loop; other site
857087000019	ATP binding site [chemical binding]; other site
857087000020	Q-loop/lid; other site
857087000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087000022	ABC transporter signature motif; other site
857087000023	Walker B; other site
857087000024	D-loop; other site
857087000025	H-loop/switch region; other site
857087000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
857087000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087000028	Mg2+ binding site [ion binding]; other site
857087000029	G-X-G motif; other site
857087000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
857087000031	anchoring element; other site
857087000032	dimer interface [polypeptide binding]; other site
857087000033	ATP binding site [chemical binding]; other site
857087000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
857087000035	active site
857087000036	putative metal-binding site [ion binding]; other site
857087000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
857087000038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087000039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087000040	non-specific DNA binding site [nucleotide binding]; other site
857087000041	salt bridge; other site
857087000042	sequence-specific DNA binding site [nucleotide binding]; other site
857087000043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087000044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087000045	non-specific DNA binding site [nucleotide binding]; other site
857087000046	salt bridge; other site
857087000047	sequence-specific DNA binding site [nucleotide binding]; other site
857087000048	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
857087000049	Integrase core domain; Region: rve; pfam00665
857087000050	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
857087000051	AAA domain; Region: AAA_22; pfam13401
857087000052	Bacterial TniB protein; Region: TniB; pfam05621
857087000053	TniQ; Region: TniQ; pfam06527
857087000054	Helix-turn-helix domain; Region: HTH_17; pfam12728
857087000055	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087000056	Sel1-like repeats; Region: SEL1; smart00671
857087000057	Sel1-like repeats; Region: SEL1; smart00671
857087000058	Sel1-like repeats; Region: SEL1; smart00671
857087000059	Sel1-like repeats; Region: SEL1; smart00671
857087000060	Sel1-like repeats; Region: SEL1; smart00671
857087000061	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
857087000062	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
857087000063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
857087000064	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
857087000065	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
857087000066	WYL domain; Region: WYL; pfam13280
857087000067	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
857087000068	AAA domain; Region: AAA_23; pfam13476
857087000069	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
857087000070	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
857087000071	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
857087000072	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
857087000073	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
857087000074	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
857087000075	SnoaL-like domain; Region: SnoaL_3; pfam13474
857087000076	AAA domain; Region: AAA_33; pfam13671
857087000077	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
857087000078	active site
857087000079	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087000080	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087000081	non-specific DNA binding site [nucleotide binding]; other site
857087000082	salt bridge; other site
857087000083	sequence-specific DNA binding site [nucleotide binding]; other site
857087000084	Homeodomain-like domain; Region: HTH_23; pfam13384
857087000085	Winged helix-turn helix; Region: HTH_29; pfam13551
857087000086	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000087	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087000088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
857087000089	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
857087000090	Integrase core domain; Region: rve; pfam00665
857087000091	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
857087000092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000093	AAA domain; Region: AAA_22; pfam13401
857087000094	Walker A motif; other site
857087000095	ATP binding site [chemical binding]; other site
857087000096	Walker B motif; other site
857087000097	TniQ; Region: TniQ; pfam06527
857087000098	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
857087000099	active site
857087000100	Zn binding site [ion binding]; other site
857087000101	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
857087000102	trimer interface [polypeptide binding]; other site
857087000103	active site
857087000104	Thymidylate synthase complementing protein; Region: Thy1; cl03630
857087000105	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
857087000106	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
857087000107	substrate binding site [chemical binding]; other site
857087000108	ATP binding site [chemical binding]; other site
857087000109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087000110	Transposase; Region: HTH_Tnp_1; pfam01527
857087000111	putative transposase OrfB; Reviewed; Region: PHA02517
857087000112	HTH-like domain; Region: HTH_21; pfam13276
857087000113	Integrase core domain; Region: rve; pfam00665
857087000114	Integrase core domain; Region: rve_3; pfam13683
857087000115	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
857087000116	Transposase; Region: HTH_Tnp_1; cl17663
857087000117	putative transposase OrfB; Reviewed; Region: PHA02517
857087000118	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000119	Integrase core domain; Region: rve; pfam00665
857087000120	Integrase core domain; Region: rve_3; pfam13683
857087000121	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
857087000122	catalytic core [active]
857087000123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000124	PAS fold; Region: PAS_3; pfam08447
857087000125	putative active site [active]
857087000126	heme pocket [chemical binding]; other site
857087000127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000128	PAS fold; Region: PAS_3; pfam08447
857087000129	putative active site [active]
857087000130	heme pocket [chemical binding]; other site
857087000131	PAS domain; Region: PAS; smart00091
857087000132	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087000133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000134	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
857087000135	putative active site [active]
857087000136	heme pocket [chemical binding]; other site
857087000137	PAS domain; Region: PAS; smart00091
857087000138	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000139	metal binding site [ion binding]; metal-binding site
857087000140	active site
857087000141	I-site; other site
857087000142	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087000143	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
857087000144	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
857087000145	active site
857087000146	metal binding site [ion binding]; metal-binding site
857087000147	periplasmic protein; Provisional; Region: PRK10568
857087000148	BON domain; Region: BON; pfam04972
857087000149	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087000150	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
857087000151	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087000152	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087000153	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087000154	ligand binding site [chemical binding]; other site
857087000155	flexible hinge region; other site
857087000156	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
857087000157	Predicted membrane protein [Function unknown]; Region: COG3671
857087000158	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
857087000159	active site
857087000160	catalytic motif [active]
857087000161	Zn binding site [ion binding]; other site
857087000162	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087000163	Radical SAM superfamily; Region: Radical_SAM; pfam04055
857087000164	FeS/SAM binding site; other site
857087000165	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
857087000166	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
857087000167	Uncharacterized conserved protein [Function unknown]; Region: COG3791
857087000168	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
857087000169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087000170	NAD(P) binding site [chemical binding]; other site
857087000171	active site
857087000172	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
857087000173	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
857087000174	FMN binding site [chemical binding]; other site
857087000175	active site
857087000176	substrate binding site [chemical binding]; other site
857087000177	catalytic residue [active]
857087000178	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
857087000179	nudix motif; other site
857087000180	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
857087000181	SPFH domain / Band 7 family; Region: Band_7; pfam01145
857087000182	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
857087000183	NADH kinase; Region: PLN02929
857087000184	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
857087000185	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
857087000186	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087000187	Coenzyme A binding pocket [chemical binding]; other site
857087000188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
857087000189	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
857087000190	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
857087000191	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
857087000192	Ferredoxin [Energy production and conversion]; Region: COG1146
857087000193	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
857087000194	elongation factor G; Reviewed; Region: PRK00007
857087000195	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
857087000196	G1 box; other site
857087000197	putative GEF interaction site [polypeptide binding]; other site
857087000198	GTP/Mg2+ binding site [chemical binding]; other site
857087000199	Switch I region; other site
857087000200	G2 box; other site
857087000201	G3 box; other site
857087000202	Switch II region; other site
857087000203	G4 box; other site
857087000204	G5 box; other site
857087000205	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
857087000206	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
857087000207	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
857087000208	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
857087000209	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
857087000210	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
857087000211	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
857087000212	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
857087000213	Walker A motif; other site
857087000214	ATP binding site [chemical binding]; other site
857087000215	Walker B motif; other site
857087000216	arginine finger; other site
857087000217	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
857087000218	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
857087000219	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
857087000220	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
857087000221	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
857087000222	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087000223	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
857087000224	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
857087000225	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
857087000226	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
857087000227	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
857087000228	active site
857087000229	metal binding site [ion binding]; metal-binding site
857087000230	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
857087000231	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087000232	ligand binding site [chemical binding]; other site
857087000233	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
857087000234	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
857087000235	Oxygen tolerance; Region: BatD; pfam13584
857087000236	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087000237	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087000238	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087000239	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087000240	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087000241	von Willebrand factor type A domain; Region: VWA_2; pfam13519
857087000242	metal ion-dependent adhesion site (MIDAS); other site
857087000243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087000244	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087000245	TPR motif; other site
857087000246	binding surface
857087000247	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
857087000248	metal ion-dependent adhesion site (MIDAS); other site
857087000249	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
857087000250	MASE1; Region: MASE1; pfam05231
857087000251	CHASE domain; Region: CHASE; pfam03924
857087000252	PAS domain S-box; Region: sensory_box; TIGR00229
857087000253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000254	putative active site [active]
857087000255	heme pocket [chemical binding]; other site
857087000256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000257	PAS domain; Region: PAS_9; pfam13426
857087000258	putative active site [active]
857087000259	heme pocket [chemical binding]; other site
857087000260	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000261	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000262	metal binding site [ion binding]; metal-binding site
857087000263	active site
857087000264	I-site; other site
857087000265	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087000266	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
857087000267	Protein of unknown function DUF58; Region: DUF58; pfam01882
857087000268	hypothetical protein; Provisional; Region: PRK10756
857087000269	CreA protein; Region: CreA; pfam05981
857087000270	MoxR-like ATPases [General function prediction only]; Region: COG0714
857087000271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000272	Walker A motif; other site
857087000273	ATP binding site [chemical binding]; other site
857087000274	Walker B motif; other site
857087000275	arginine finger; other site
857087000276	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
857087000277	dihydroorotase; Provisional; Region: PRK07627
857087000278	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
857087000279	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
857087000280	active site
857087000281	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
857087000282	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
857087000283	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
857087000284	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
857087000285	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087000286	active site
857087000287	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087000288	dimerization interface [polypeptide binding]; other site
857087000289	putative DNA binding site [nucleotide binding]; other site
857087000290	putative Zn2+ binding site [ion binding]; other site
857087000291	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
857087000292	putative transposase OrfB; Reviewed; Region: PHA02517
857087000293	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000294	Integrase core domain; Region: rve; pfam00665
857087000295	Integrase core domain; Region: rve_3; pfam13683
857087000296	Transposase; Region: HTH_Tnp_1; cl17663
857087000297	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
857087000298	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
857087000299	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
857087000300	hypothetical protein; Validated; Region: PRK00228
857087000301	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
857087000302	glutathione synthetase; Provisional; Region: PRK05246
857087000303	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
857087000304	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
857087000305	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
857087000306	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
857087000307	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087000308	ligand binding site [chemical binding]; other site
857087000309	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087000310	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087000311	ligand binding site [chemical binding]; other site
857087000312	flexible hinge region; other site
857087000313	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087000314	active site residue [active]
857087000315	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
857087000316	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
857087000317	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
857087000318	protein binding site [polypeptide binding]; other site
857087000319	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
857087000320	PAS domain; Region: PAS_9; pfam13426
857087000321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000322	putative active site [active]
857087000323	heme pocket [chemical binding]; other site
857087000324	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087000325	GAF domain; Region: GAF; pfam01590
857087000326	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
857087000327	Part of AAA domain; Region: AAA_19; pfam13245
857087000328	Family description; Region: UvrD_C_2; pfam13538
857087000329	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
857087000330	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
857087000331	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
857087000332	active site
857087000333	HIGH motif; other site
857087000334	nucleotide binding site [chemical binding]; other site
857087000335	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
857087000336	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
857087000337	active site
857087000338	KMSKS motif; other site
857087000339	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
857087000340	tRNA binding surface [nucleotide binding]; other site
857087000341	anticodon binding site; other site
857087000342	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
857087000343	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
857087000344	short chain dehydrogenase; Provisional; Region: PRK05993
857087000345	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
857087000346	NADP binding site [chemical binding]; other site
857087000347	active site
857087000348	steroid binding site; other site
857087000349	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
857087000350	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
857087000351	Uncharacterized conserved protein [Function unknown]; Region: COG1615
857087000352	multicopper oxidase; Provisional; Region: PRK10965
857087000353	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
857087000354	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
857087000355	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
857087000356	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
857087000357	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
857087000358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000360	metal binding site [ion binding]; metal-binding site
857087000361	active site
857087000362	I-site; other site
857087000363	RmuC family; Region: RmuC; pfam02646
857087000364	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000365	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000366	metal binding site [ion binding]; metal-binding site
857087000367	active site
857087000368	I-site; other site
857087000369	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
857087000370	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
857087000371	catalytic residues [active]
857087000372	hinge region; other site
857087000373	alpha helical domain; other site
857087000374	Cytochrome c553 [Energy production and conversion]; Region: COG2863
857087000375	Cytochrome c; Region: Cytochrom_C; cl11414
857087000376	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
857087000377	Dynamin family; Region: Dynamin_N; pfam00350
857087000378	G1 box; other site
857087000379	GTP/Mg2+ binding site [chemical binding]; other site
857087000380	Switch I region; other site
857087000381	G2 box; other site
857087000382	G3 box; other site
857087000383	Switch II region; other site
857087000384	G4 box; other site
857087000385	G5 box; other site
857087000386	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
857087000387	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
857087000388	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
857087000389	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
857087000390	Zeta toxin; Region: Zeta_toxin; pfam06414
857087000391	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087000392	GAF domain; Region: GAF; pfam01590
857087000393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000394	PAS domain; Region: PAS_9; pfam13426
857087000395	putative active site [active]
857087000396	heme pocket [chemical binding]; other site
857087000397	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000398	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000399	metal binding site [ion binding]; metal-binding site
857087000400	active site
857087000401	I-site; other site
857087000402	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087000403	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
857087000404	HDOD domain; Region: HDOD; pfam08668
857087000405	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087000406	Zn2+ binding site [ion binding]; other site
857087000407	Mg2+ binding site [ion binding]; other site
857087000408	DNA polymerase I; Provisional; Region: PRK05755
857087000409	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
857087000410	active site
857087000411	metal binding site 1 [ion binding]; metal-binding site
857087000412	putative 5' ssDNA interaction site; other site
857087000413	metal binding site 3; metal-binding site
857087000414	metal binding site 2 [ion binding]; metal-binding site
857087000415	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
857087000416	putative DNA binding site [nucleotide binding]; other site
857087000417	putative metal binding site [ion binding]; other site
857087000418	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
857087000419	active site
857087000420	catalytic site [active]
857087000421	substrate binding site [chemical binding]; other site
857087000422	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
857087000423	active site
857087000424	DNA binding site [nucleotide binding]
857087000425	catalytic site [active]
857087000426	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087000427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087000428	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
857087000429	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087000430	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087000431	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087000432	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087000433	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
857087000434	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
857087000435	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087000436	catalytic residues [active]
857087000437	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
857087000438	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
857087000439	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
857087000440	ApbE family; Region: ApbE; pfam02424
857087000441	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
857087000442	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
857087000443	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
857087000444	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
857087000445	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
857087000446	TMAO/DMSO reductase; Reviewed; Region: PRK05363
857087000447	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
857087000448	Moco binding site; other site
857087000449	metal coordination site [ion binding]; other site
857087000450	Predicted membrane protein [Function unknown]; Region: COG2259
857087000451	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
857087000452	hypothetical protein; Provisional; Region: PRK05409
857087000453	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
857087000454	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
857087000455	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
857087000456	GAF domain; Region: GAF; cl17456
857087000457	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
857087000458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000459	putative active site [active]
857087000460	heme pocket [chemical binding]; other site
857087000461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000462	Walker A motif; other site
857087000463	ATP binding site [chemical binding]; other site
857087000464	Walker B motif; other site
857087000465	arginine finger; other site
857087000466	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590
857087000467	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590
857087000468	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
857087000469	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
857087000470	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
857087000471	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
857087000472	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087000473	putative membrane fusion protein; Region: TIGR02828
857087000474	Outer membrane efflux protein; Region: OEP; pfam02321
857087000475	Outer membrane efflux protein; Region: OEP; pfam02321
857087000476	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
857087000477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087000478	S-adenosylmethionine binding site [chemical binding]; other site
857087000479	spermidine synthase; Provisional; Region: PRK00811
857087000480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087000481	S-adenosylmethionine binding site [chemical binding]; other site
857087000482	arginine decarboxylase; Provisional; Region: PRK05354
857087000483	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
857087000484	dimer interface [polypeptide binding]; other site
857087000485	active site
857087000486	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087000487	catalytic residues [active]
857087000488	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
857087000489	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
857087000490	active site
857087000491	catalytic triad [active]
857087000492	oxyanion hole [active]
857087000493	switch loop; other site
857087000494	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
857087000495	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
857087000496	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
857087000497	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
857087000498	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
857087000499	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
857087000500	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
857087000501	active site
857087000502	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
857087000503	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
857087000504	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
857087000505	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
857087000506	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
857087000507	UbiA prenyltransferase family; Region: UbiA; pfam01040
857087000508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087000509	AAA domain; Region: AAA_21; pfam13304
857087000510	Q-loop/lid; other site
857087000511	ABC transporter signature motif; other site
857087000512	Walker B; other site
857087000513	D-loop; other site
857087000514	H-loop/switch region; other site
857087000515	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
857087000516	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
857087000517	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
857087000518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087000519	Walker A/P-loop; other site
857087000520	ATP binding site [chemical binding]; other site
857087000521	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
857087000522	Active Sites [active]
857087000523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087000524	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087000525	non-specific DNA binding site [nucleotide binding]; other site
857087000526	salt bridge; other site
857087000527	sequence-specific DNA binding site [nucleotide binding]; other site
857087000528	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
857087000529	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
857087000530	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
857087000531	putative ribose interaction site [chemical binding]; other site
857087000532	putative ADP binding site [chemical binding]; other site
857087000533	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
857087000534	active site
857087000535	nucleotide binding site [chemical binding]; other site
857087000536	HIGH motif; other site
857087000537	KMSKS motif; other site
857087000538	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
857087000539	ArsC family; Region: ArsC; pfam03960
857087000540	catalytic residues [active]
857087000541	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
857087000542	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
857087000543	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
857087000544	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
857087000545	GDP-Fucose binding site [chemical binding]; other site
857087000546	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087000547	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
857087000548	active site
857087000549	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
857087000550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087000551	binding surface
857087000552	TPR motif; other site
857087000553	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087000554	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
857087000555	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
857087000556	Peptidase M15; Region: Peptidase_M15_3; cl01194
857087000557	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
857087000558	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
857087000559	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087000560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087000561	ABC transporter; Region: ABC_tran_2; pfam12848
857087000562	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087000563	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
857087000564	Ligand Binding Site [chemical binding]; other site
857087000565	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
857087000566	homotrimer interface [polypeptide binding]; other site
857087000567	Walker A motif; other site
857087000568	GTP binding site [chemical binding]; other site
857087000569	Walker B motif; other site
857087000570	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
857087000571	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
857087000572	putative dimer interface [polypeptide binding]; other site
857087000573	active site pocket [active]
857087000574	putative cataytic base [active]
857087000575	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
857087000576	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
857087000577	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087000578	Outer membrane efflux protein; Region: OEP; pfam02321
857087000579	Outer membrane efflux protein; Region: OEP; pfam02321
857087000580	TM2 domain; Region: TM2; pfam05154
857087000581	cobalamin synthase; Reviewed; Region: cobS; PRK00235
857087000582	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
857087000583	putative FMN binding site [chemical binding]; other site
857087000584	cobyric acid synthase; Provisional; Region: PRK00784
857087000585	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
857087000586	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
857087000587	catalytic triad [active]
857087000588	NMT1/THI5 like; Region: NMT1; pfam09084
857087000589	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
857087000590	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087000591	substrate binding pocket [chemical binding]; other site
857087000592	membrane-bound complex binding site; other site
857087000593	hinge residues; other site
857087000594	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087000595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000596	heme pocket [chemical binding]; other site
857087000597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087000598	PAS domain; Region: PAS_9; pfam13426
857087000599	putative active site [active]
857087000600	heme pocket [chemical binding]; other site
857087000601	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000603	metal binding site [ion binding]; metal-binding site
857087000604	active site
857087000605	I-site; other site
857087000606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087000607	TPR motif; other site
857087000608	binding surface
857087000609	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
857087000610	putative active site [active]
857087000611	putative metal binding residues [ion binding]; other site
857087000612	signature motif; other site
857087000613	putative dimer interface [polypeptide binding]; other site
857087000614	putative phosphate binding site [ion binding]; other site
857087000615	superoxide dismutase; Provisional; Region: PRK10543
857087000616	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
857087000617	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
857087000618	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087000619	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087000620	metal binding site [ion binding]; metal-binding site
857087000621	active site
857087000622	I-site; other site
857087000623	Autotransporter beta-domain; Region: Autotransporter; smart00869
857087000624	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
857087000625	nickel binding site [ion binding]; other site
857087000626	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
857087000627	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
857087000628	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
857087000629	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
857087000630	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087000631	catalytic loop [active]
857087000632	iron binding site [ion binding]; other site
857087000633	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
857087000634	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
857087000635	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087000636	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
857087000637	SLBB domain; Region: SLBB; pfam10531
857087000638	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
857087000639	Protein of unknown function (DUF721); Region: DUF721; pfam05258
857087000640	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
857087000641	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
857087000642	cell division protein FtsZ; Validated; Region: PRK09330
857087000643	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
857087000644	nucleotide binding site [chemical binding]; other site
857087000645	SulA interaction site; other site
857087000646	cell division protein FtsA; Region: ftsA; TIGR01174
857087000647	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
857087000648	nucleotide binding site [chemical binding]; other site
857087000649	Cell division protein FtsA; Region: FtsA; pfam14450
857087000650	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
857087000651	Cell division protein FtsQ; Region: FtsQ; pfam03799
857087000652	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
857087000653	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
857087000654	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087000655	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
857087000656	FAD binding domain; Region: FAD_binding_4; pfam01565
857087000657	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
857087000658	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
857087000659	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
857087000660	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
857087000661	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087000662	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
857087000663	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
857087000664	active site
857087000665	homodimer interface [polypeptide binding]; other site
857087000666	cell division protein FtsW; Region: ftsW; TIGR02614
857087000667	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
857087000668	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
857087000669	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087000670	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
857087000671	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
857087000672	Mg++ binding site [ion binding]; other site
857087000673	putative catalytic motif [active]
857087000674	putative substrate binding site [chemical binding]; other site
857087000675	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
857087000676	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
857087000677	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
857087000678	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087000679	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
857087000680	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
857087000681	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
857087000682	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087000683	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
857087000684	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
857087000685	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
857087000686	Cell division protein FtsL; Region: FtsL; cl11433
857087000687	MraW methylase family; Region: Methyltransf_5; pfam01795
857087000688	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
857087000689	cell division protein MraZ; Reviewed; Region: PRK00326
857087000690	MraZ protein; Region: MraZ; pfam02381
857087000691	MraZ protein; Region: MraZ; pfam02381
857087000692	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
857087000693	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
857087000694	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
857087000695	preprotein translocase subunit SecB; Validated; Region: PRK05751
857087000696	SecA binding site; other site
857087000697	Preprotein binding site; other site
857087000698	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087000699	active site residue [active]
857087000700	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087000701	dimerization interface [polypeptide binding]; other site
857087000702	putative DNA binding site [nucleotide binding]; other site
857087000703	putative Zn2+ binding site [ion binding]; other site
857087000704	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
857087000705	Peptidase family M23; Region: Peptidase_M23; pfam01551
857087000706	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
857087000707	C-terminal peptidase (prc); Region: prc; TIGR00225
857087000708	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
857087000709	protein binding site [polypeptide binding]; other site
857087000710	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
857087000711	Catalytic dyad [active]
857087000712	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
857087000713	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
857087000714	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
857087000715	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
857087000716	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
857087000717	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
857087000718	muropeptide transporter; Validated; Region: ampG; cl17669
857087000719	muropeptide transporter; Reviewed; Region: ampG; PRK11902
857087000720	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
857087000721	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
857087000722	Transglycosylase; Region: Transgly; pfam00912
857087000723	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
857087000724	Competence protein A; Region: Competence_A; pfam11104
857087000725	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
857087000726	nucleotide binding site [chemical binding]; other site
857087000727	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
857087000728	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
857087000729	Pilus assembly protein, PilO; Region: PilO; pfam04350
857087000730	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
857087000731	Pilus assembly protein, PilP; Region: PilP; pfam04351
857087000732	AMIN domain; Region: AMIN; pfam11741
857087000733	Secretin and TonB N terminus short domain; Region: STN; pfam07660
857087000734	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087000735	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
857087000736	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
857087000737	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
857087000738	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
857087000739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000740	Walker A motif; other site
857087000741	ATP binding site [chemical binding]; other site
857087000742	Walker B motif; other site
857087000743	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
857087000744	Membrane fusogenic activity; Region: BMFP; pfam04380
857087000745	Transcriptional regulators [Transcription]; Region: MarR; COG1846
857087000746	MarR family; Region: MarR_2; pfam12802
857087000747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087000748	Walker A motif; other site
857087000749	ATP binding site [chemical binding]; other site
857087000750	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087000751	Walker B motif; other site
857087000752	arginine finger; other site
857087000753	Rubella membrane glycoprotein E1; Region: Rubella_E1; pfam05748
857087000754	Protein of unknown function DUF58; Region: DUF58; pfam01882
857087000755	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
857087000756	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087000757	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087000758	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
857087000759	Conotoxin; Region: Conotoxin; pfam02950
857087000760	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
857087000761	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
857087000762	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
857087000763	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087000764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087000765	active site
857087000766	phosphorylation site [posttranslational modification]
857087000767	intermolecular recognition site; other site
857087000768	dimerization interface [polypeptide binding]; other site
857087000769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087000770	DNA binding site [nucleotide binding]
857087000771	sensor protein QseC; Provisional; Region: PRK10337
857087000772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087000773	dimer interface [polypeptide binding]; other site
857087000774	phosphorylation site [posttranslational modification]
857087000775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087000776	ATP binding site [chemical binding]; other site
857087000777	Mg2+ binding site [ion binding]; other site
857087000778	G-X-G motif; other site
857087000779	BNR repeat-like domain; Region: BNR_2; pfam13088
857087000780	BNR repeat-like domain; Region: BNR_2; pfam13088
857087000781	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
857087000782	CopC domain; Region: CopC; pfam04234
857087000783	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
857087000784	Ammonia monooxygenase/methane monooxygenase, subunit C; Region: AmoC; cl04829
857087000785	Ammonia monooxygenase; Region: AMO; pfam02461
857087000786	methane monooxygenase/ammonia monooxygenase, subunit B; Region: CH4_NH3mon_ox_B; TIGR03079
857087000787	Monooxygenase subunit B protein; Region: Monooxygenase_B; pfam04744
857087000788	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
857087000789	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
857087000790	dimer interface [polypeptide binding]; other site
857087000791	active site
857087000792	citrylCoA binding site [chemical binding]; other site
857087000793	NADH binding [chemical binding]; other site
857087000794	cationic pore residues; other site
857087000795	oxalacetate/citrate binding site [chemical binding]; other site
857087000796	coenzyme A binding site [chemical binding]; other site
857087000797	catalytic triad [active]
857087000798	Late competence development protein ComFB; Region: ComFB; pfam10719
857087000799	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087000800	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
857087000801	FtsX-like permease family; Region: FtsX; pfam02687
857087000802	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087000803	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
857087000804	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
857087000805	EamA-like transporter family; Region: EamA; pfam00892
857087000806	EamA-like transporter family; Region: EamA; pfam00892
857087000807	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
857087000808	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
857087000809	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
857087000810	Dicarboxylate transport; Region: DctA-YdbH; cl14674
857087000811	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
857087000812	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
857087000813	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
857087000814	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
857087000815	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087000816	Walker A motif; other site
857087000817	ATP binding site [chemical binding]; other site
857087000818	Walker B motif; other site
857087000819	HDOD domain; Region: HDOD; pfam08668
857087000820	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087000821	Zn2+ binding site [ion binding]; other site
857087000822	Mg2+ binding site [ion binding]; other site
857087000823	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087000824	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087000825	putative active site [active]
857087000826	putative NTP binding site [chemical binding]; other site
857087000827	putative nucleic acid binding site [nucleotide binding]; other site
857087000828	putative transposase OrfB; Reviewed; Region: PHA02517
857087000829	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000830	Integrase core domain; Region: rve; pfam00665
857087000831	Integrase core domain; Region: rve_3; pfam13683
857087000832	Transposase; Region: HTH_Tnp_1; cl17663
857087000833	putative transposase OrfB; Reviewed; Region: PHA02517
857087000834	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000835	Integrase core domain; Region: rve; pfam00665
857087000836	Integrase core domain; Region: rve_3; pfam13683
857087000837	Homeodomain-like domain; Region: HTH_23; pfam13384
857087000838	Winged helix-turn helix; Region: HTH_29; pfam13551
857087000839	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000840	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087000841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
857087000842	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
857087000843	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
857087000844	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
857087000845	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
857087000846	flavodoxin FldA; Validated; Region: PRK09267
857087000847	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
857087000848	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
857087000849	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
857087000850	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
857087000851	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
857087000852	dimer interface [polypeptide binding]; other site
857087000853	active site
857087000854	Predicted exporter [General function prediction only]; Region: COG4258
857087000855	Predicted membrane protein [Function unknown]; Region: COG4648
857087000856	Phosphopantetheine attachment site; Region: PP-binding; cl09936
857087000857	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
857087000858	Phosphopantetheine attachment site; Region: PP-binding; cl09936
857087000859	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
857087000860	AMP-binding enzyme; Region: AMP-binding; pfam00501
857087000861	acyl-activating enzyme (AAE) consensus motif; other site
857087000862	AMP binding site [chemical binding]; other site
857087000863	active site
857087000864	CoA binding site [chemical binding]; other site
857087000865	TIR domain; Region: TIR_2; pfam13676
857087000866	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
857087000867	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
857087000868	active site
857087000869	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087000870	active site residue [active]
857087000871	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
857087000872	Domain of unknown function DUF20; Region: UPF0118; pfam01594
857087000873	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
857087000874	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087000875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087000876	homodimer interface [polypeptide binding]; other site
857087000877	catalytic residue [active]
857087000878	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
857087000879	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087000880	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
857087000881	N-terminal plug; other site
857087000882	ligand-binding site [chemical binding]; other site
857087000883	FliW protein; Region: FliW; cl00740
857087000884	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
857087000885	tetramerization interface [polypeptide binding]; other site
857087000886	active site
857087000887	Pantoate-beta-alanine ligase; Region: PanC; cd00560
857087000888	pantoate--beta-alanine ligase; Region: panC; TIGR00018
857087000889	active site
857087000890	ATP-binding site [chemical binding]; other site
857087000891	pantoate-binding site; other site
857087000892	HXXH motif; other site
857087000893	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
857087000894	oligomerization interface [polypeptide binding]; other site
857087000895	active site
857087000896	metal binding site [ion binding]; metal-binding site
857087000897	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
857087000898	catalytic center binding site [active]
857087000899	ATP binding site [chemical binding]; other site
857087000900	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
857087000901	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
857087000902	active site
857087000903	NTP binding site [chemical binding]; other site
857087000904	metal binding triad [ion binding]; metal-binding site
857087000905	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
857087000906	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
857087000907	RDD family; Region: RDD; pfam06271
857087000908	TIGR03790 family protein; Region: TIGR03790
857087000909	YcxB-like protein; Region: YcxB; pfam14317
857087000910	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
857087000911	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087000912	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
857087000913	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
857087000914	diaminopimelate decarboxylase; Region: lysA; TIGR01048
857087000915	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
857087000916	active site
857087000917	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087000918	substrate binding site [chemical binding]; other site
857087000919	catalytic residues [active]
857087000920	dimer interface [polypeptide binding]; other site
857087000921	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
857087000922	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
857087000923	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
857087000924	Protein of unknown function, DUF484; Region: DUF484; cl17449
857087000925	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
857087000926	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
857087000927	active site
857087000928	Int/Topo IB signature motif; other site
857087000929	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087000930	HTH domain; Region: HTH_11; cl17392
857087000931	Integrase core domain; Region: rve; pfam00665
857087000932	Transposase; Region: HTH_Tnp_1; cl17663
857087000933	putative transposase OrfB; Reviewed; Region: PHA02517
857087000934	Homeodomain-like domain; Region: HTH_32; pfam13565
857087000935	Integrase core domain; Region: rve; pfam00665
857087000936	Integrase core domain; Region: rve_3; pfam13683
857087000937	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
857087000938	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
857087000939	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087000940	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087000941	phosphoglucomutase; Region: PLN02307
857087000942	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
857087000943	substrate binding site [chemical binding]; other site
857087000944	dimer interface [polypeptide binding]; other site
857087000945	active site
857087000946	metal binding site [ion binding]; metal-binding site
857087000947	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
857087000948	L,D-transpeptidase; Provisional; Region: PRK10190
857087000949	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
857087000950	Putative exonuclease, RdgC; Region: RdgC; pfam04381
857087000951	Protein of unknown function (DUF615); Region: DUF615; pfam04751
857087000952	Transglycosylase; Region: Transgly; cl17702
857087000953	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
857087000954	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
857087000955	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
857087000956	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
857087000957	active site
857087000958	Riboflavin kinase; Region: Flavokinase; smart00904
857087000959	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
857087000960	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
857087000961	classical (c) SDRs; Region: SDR_c; cd05233
857087000962	NAD(P) binding site [chemical binding]; other site
857087000963	active site
857087000964	Ion channel; Region: Ion_trans_2; pfam07885
857087000965	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
857087000966	TrkA-N domain; Region: TrkA_N; pfam02254
857087000967	TrkA-C domain; Region: TrkA_C; pfam02080
857087000968	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
857087000969	TrkA-N domain; Region: TrkA_N; pfam02254
857087000970	TrkA-C domain; Region: TrkA_C; pfam02080
857087000971	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
857087000972	primosome assembly protein PriA; Validated; Region: PRK05580
857087000973	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087000974	ATP binding site [chemical binding]; other site
857087000975	putative Mg++ binding site [ion binding]; other site
857087000976	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
857087000977	helicase superfamily c-terminal domain; Region: HELICc; smart00490
857087000978	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
857087000979	NlpC/P60 family; Region: NLPC_P60; pfam00877
857087000980	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
857087000981	active site
857087000982	DNA polymerase IV; Validated; Region: PRK02406
857087000983	DNA binding site [nucleotide binding]
857087000984	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
857087000985	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
857087000986	YcgL domain; Region: YcgL; cl01189
857087000987	CAAX protease self-immunity; Region: Abi; pfam02517
857087000988	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
857087000989	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
857087000990	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
857087000991	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
857087000992	active site
857087000993	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087000994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087000995	S-adenosylmethionine binding site [chemical binding]; other site
857087000996	GMP synthase; Reviewed; Region: guaA; PRK00074
857087000997	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
857087000998	AMP/PPi binding site [chemical binding]; other site
857087000999	candidate oxyanion hole; other site
857087001000	catalytic triad [active]
857087001001	potential glutamine specificity residues [chemical binding]; other site
857087001002	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
857087001003	ATP Binding subdomain [chemical binding]; other site
857087001004	Ligand Binding sites [chemical binding]; other site
857087001005	Dimerization subdomain; other site
857087001006	Putative addiction module component; Region: Unstab_antitox; pfam09720
857087001007	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
857087001008	adenine DNA glycosylase; Provisional; Region: PRK10880
857087001009	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
857087001010	minor groove reading motif; other site
857087001011	helix-hairpin-helix signature motif; other site
857087001012	substrate binding pocket [chemical binding]; other site
857087001013	active site
857087001014	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
857087001015	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
857087001016	DNA binding and oxoG recognition site [nucleotide binding]
857087001017	oxidative damage protection protein; Provisional; Region: PRK05408
857087001018	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087001019	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
857087001020	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087001021	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087001022	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
857087001023	trimer interface [polypeptide binding]; other site
857087001024	active site
857087001025	substrate binding site [chemical binding]; other site
857087001026	CoA binding site [chemical binding]; other site
857087001027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087001028	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087001029	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087001030	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
857087001031	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
857087001032	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
857087001033	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
857087001034	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
857087001035	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
857087001036	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
857087001037	Mg++ binding site [ion binding]; other site
857087001038	putative catalytic motif [active]
857087001039	substrate binding site [chemical binding]; other site
857087001040	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
857087001041	active site
857087001042	dimer interface [polypeptide binding]; other site
857087001043	shikimate kinase; Reviewed; Region: aroK; PRK00131
857087001044	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
857087001045	ADP binding site [chemical binding]; other site
857087001046	magnesium binding site [ion binding]; other site
857087001047	putative shikimate binding site; other site
857087001048	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
857087001049	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
857087001050	active site
857087001051	dimer interface [polypeptide binding]; other site
857087001052	metal binding site [ion binding]; metal-binding site
857087001053	Archaeal ATPase; Region: Arch_ATPase; pfam01637
857087001054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087001055	Walker A motif; other site
857087001056	ATP binding site [chemical binding]; other site
857087001057	Walker B motif; other site
857087001058	Sporulation related domain; Region: SPOR; cl10051
857087001059	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
857087001060	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
857087001061	substrate binding site [chemical binding]; other site
857087001062	active site
857087001063	RNA polymerase sigma factor; Reviewed; Region: PRK12523
857087001064	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087001065	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087001066	DNA binding residues [nucleotide binding]
857087001067	fec operon regulator FecR; Reviewed; Region: PRK09774
857087001068	FecR protein; Region: FecR; pfam04773
857087001069	PemK-like protein; Region: PemK; pfam02452
857087001070	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
857087001071	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087001072	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087001073	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087001074	N-terminal plug; other site
857087001075	ligand-binding site [chemical binding]; other site
857087001076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087001077	Transposase; Region: HTH_Tnp_1; pfam01527
857087001078	putative transposase OrfB; Reviewed; Region: PHA02517
857087001079	HTH-like domain; Region: HTH_21; pfam13276
857087001080	Integrase core domain; Region: rve; pfam00665
857087001081	Integrase core domain; Region: rve_3; pfam13683
857087001082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087001083	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087001084	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087001085	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087001086	DNA binding residues [nucleotide binding]
857087001087	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087001088	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
857087001089	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087001090	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087001091	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087001092	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087001093	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087001094	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
857087001095	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
857087001096	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087001097	ligand binding site [chemical binding]; other site
857087001098	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
857087001099	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
857087001100	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
857087001101	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
857087001102	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
857087001103	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
857087001104	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
857087001105	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
857087001106	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
857087001107	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
857087001108	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087001109	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
857087001110	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
857087001111	active site
857087001112	dimer interface [polypeptide binding]; other site
857087001113	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
857087001114	dimer interface [polypeptide binding]; other site
857087001115	active site
857087001116	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
857087001117	Predicted membrane protein [Function unknown]; Region: COG1238
857087001118	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
857087001119	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
857087001120	HIGH motif; other site
857087001121	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
857087001122	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
857087001123	active site
857087001124	KMSKS motif; other site
857087001125	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
857087001126	tRNA binding surface [nucleotide binding]; other site
857087001127	anticodon binding site; other site
857087001128	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
857087001129	HDOD domain; Region: HDOD; pfam08668
857087001130	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
857087001131	GAF domain; Region: GAF; cl17456
857087001132	Response regulator receiver domain; Region: Response_reg; pfam00072
857087001133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087001134	active site
857087001135	phosphorylation site [posttranslational modification]
857087001136	intermolecular recognition site; other site
857087001137	dimerization interface [polypeptide binding]; other site
857087001138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087001139	Response regulator receiver domain; Region: Response_reg; pfam00072
857087001140	active site
857087001141	phosphorylation site [posttranslational modification]
857087001142	intermolecular recognition site; other site
857087001143	dimerization interface [polypeptide binding]; other site
857087001144	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
857087001145	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
857087001146	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
857087001147	Walker A motif; other site
857087001148	ATP binding site [chemical binding]; other site
857087001149	Walker B motif; other site
857087001150	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
857087001151	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087001152	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087001153	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
857087001154	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
857087001155	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
857087001156	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
857087001157	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
857087001158	CoA-binding site [chemical binding]; other site
857087001159	ATP-binding [chemical binding]; other site
857087001160	hypothetical protein; Provisional; Region: PRK05287
857087001161	Domain of unknown function (DUF329); Region: DUF329; pfam03884
857087001162	hypothetical protein; Provisional; Region: PRK08999
857087001163	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
857087001164	active site
857087001165	8-oxo-dGMP binding site [chemical binding]; other site
857087001166	nudix motif; other site
857087001167	metal binding site [ion binding]; metal-binding site
857087001168	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
857087001169	thiamine phosphate binding site [chemical binding]; other site
857087001170	active site
857087001171	pyrophosphate binding site [ion binding]; other site
857087001172	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
857087001173	heterotetramer interface [polypeptide binding]; other site
857087001174	active site pocket [active]
857087001175	cleavage site
857087001176	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
857087001177	CPxP  motif; other site
857087001178	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
857087001179	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
857087001180	Ligand Binding Site [chemical binding]; other site
857087001181	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
857087001182	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087001183	Walker A motif; other site
857087001184	ATP binding site [chemical binding]; other site
857087001185	Walker B motif; other site
857087001186	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
857087001187	intersubunit interface [polypeptide binding]; other site
857087001188	active site
857087001189	zinc binding site [ion binding]; other site
857087001190	Na+ binding site [ion binding]; other site
857087001191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
857087001192	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
857087001193	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087001194	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
857087001195	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
857087001196	tetramer interface [polypeptide binding]; other site
857087001197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087001198	catalytic residue [active]
857087001199	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
857087001200	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
857087001201	putative ligand binding site [chemical binding]; other site
857087001202	PAS domain S-box; Region: sensory_box; TIGR00229
857087001203	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087001204	putative active site [active]
857087001205	heme pocket [chemical binding]; other site
857087001206	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087001207	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087001208	metal binding site [ion binding]; metal-binding site
857087001209	active site
857087001210	I-site; other site
857087001211	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087001212	Sensors of blue-light using FAD; Region: BLUF; pfam04940
857087001213	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087001214	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087001215	Protein of unknown function DUF45; Region: DUF45; pfam01863
857087001216	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
857087001217	apolar tunnel; other site
857087001218	heme binding site [chemical binding]; other site
857087001219	dimerization interface [polypeptide binding]; other site
857087001220	YccA-like proteins; Region: YccA_like; cd10433
857087001221	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
857087001222	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
857087001223	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
857087001224	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
857087001225	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
857087001226	DctM-like transporters; Region: DctM; pfam06808
857087001227	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
857087001228	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
857087001229	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
857087001230	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
857087001231	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
857087001232	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
857087001233	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
857087001234	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
857087001235	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
857087001236	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
857087001237	RNA binding site [nucleotide binding]; other site
857087001238	putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073
857087001239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087001240	Walker A/P-loop; other site
857087001241	ATP binding site [chemical binding]; other site
857087001242	Q-loop/lid; other site
857087001243	exonuclease subunit SbcC; Provisional; Region: PRK10246
857087001244	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087001245	ABC transporter signature motif; other site
857087001246	Walker B; other site
857087001247	D-loop; other site
857087001248	H-loop/switch region; other site
857087001249	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
857087001250	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
857087001251	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
857087001252	active site
857087001253	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
857087001254	core domain interface [polypeptide binding]; other site
857087001255	delta subunit interface [polypeptide binding]; other site
857087001256	epsilon subunit interface [polypeptide binding]; other site
857087001257	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
857087001258	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087001259	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087001260	Walker A motif; other site
857087001261	ATP binding site [chemical binding]; other site
857087001262	Walker B motif; other site
857087001263	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
857087001264	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
857087001265	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
857087001266	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
857087001267	ATP synthase A chain; Region: ATP-synt_A; cl00413
857087001268	N-ATPase, AtpR subunit; Region: AtpR; pfam12966
857087001269	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
857087001270	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
857087001271	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
857087001272	gamma subunit interface [polypeptide binding]; other site
857087001273	epsilon subunit interface [polypeptide binding]; other site
857087001274	LBP interface [polypeptide binding]; other site
857087001275	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
857087001276	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087001277	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
857087001278	alpha subunit interaction interface [polypeptide binding]; other site
857087001279	Walker A motif; other site
857087001280	ATP binding site [chemical binding]; other site
857087001281	Walker B motif; other site
857087001282	inhibitor binding site; inhibition site
857087001283	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
857087001284	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
857087001285	active site
857087001286	intersubunit interactions; other site
857087001287	catalytic residue [active]
857087001288	Predicted membrane protein [Function unknown]; Region: COG3503
857087001289	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087001290	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087001291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087001292	S-adenosylmethionine binding site [chemical binding]; other site
857087001293	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
857087001294	bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840
857087001295	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
857087001296	thiS-thiF/thiG interaction site; other site
857087001297	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
857087001298	ThiS interaction site; other site
857087001299	putative active site [active]
857087001300	tetramer interface [polypeptide binding]; other site
857087001301	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
857087001302	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
857087001303	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
857087001304	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
857087001305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087001306	Transposase; Region: HTH_Tnp_1; pfam01527
857087001307	putative transposase OrfB; Reviewed; Region: PHA02517
857087001308	HTH-like domain; Region: HTH_21; pfam13276
857087001309	Integrase core domain; Region: rve; pfam00665
857087001310	Integrase core domain; Region: rve_3; pfam13683
857087001311	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087001312	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087001313	putative active site [active]
857087001314	putative NTP binding site [chemical binding]; other site
857087001315	putative nucleic acid binding site [nucleotide binding]; other site
857087001316	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087001317	Transposase; Region: HTH_Tnp_1; cl17663
857087001318	putative transposase OrfB; Reviewed; Region: PHA02517
857087001319	Homeodomain-like domain; Region: HTH_32; pfam13565
857087001320	Integrase core domain; Region: rve; pfam00665
857087001321	Integrase core domain; Region: rve_3; pfam13683
857087001322	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
857087001323	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
857087001324	CysD dimerization site [polypeptide binding]; other site
857087001325	G1 box; other site
857087001326	putative GEF interaction site [polypeptide binding]; other site
857087001327	GTP/Mg2+ binding site [chemical binding]; other site
857087001328	Switch I region; other site
857087001329	G2 box; other site
857087001330	G3 box; other site
857087001331	Switch II region; other site
857087001332	G4 box; other site
857087001333	G5 box; other site
857087001334	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
857087001335	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
857087001336	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
857087001337	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
857087001338	Active Sites [active]
857087001339	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087001340	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087001341	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087001342	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
857087001343	active site clefts [active]
857087001344	zinc binding site [ion binding]; other site
857087001345	dimer interface [polypeptide binding]; other site
857087001346	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
857087001347	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087001348	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
857087001349	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087001350	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087001351	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
857087001352	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
857087001353	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
857087001354	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087001355	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
857087001356	Maf-like protein; Region: Maf; pfam02545
857087001357	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
857087001358	active site
857087001359	dimer interface [polypeptide binding]; other site
857087001360	ribonuclease G; Provisional; Region: PRK11712
857087001361	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
857087001362	homodimer interface [polypeptide binding]; other site
857087001363	oligonucleotide binding site [chemical binding]; other site
857087001364	TIGR02099 family protein; Region: TIGR02099
857087001365	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
857087001366	nitrilase; Region: PLN02798
857087001367	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
857087001368	putative active site [active]
857087001369	catalytic triad [active]
857087001370	dimer interface [polypeptide binding]; other site
857087001371	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
857087001372	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
857087001373	trimer interface [polypeptide binding]; other site
857087001374	dimer interface [polypeptide binding]; other site
857087001375	putative active site [active]
857087001376	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
857087001377	MoaE interaction surface [polypeptide binding]; other site
857087001378	MoeB interaction surface [polypeptide binding]; other site
857087001379	thiocarboxylated glycine; other site
857087001380	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
857087001381	MoaE homodimer interface [polypeptide binding]; other site
857087001382	MoaD interaction [polypeptide binding]; other site
857087001383	active site residues [active]
857087001384	NlpE N-terminal domain; Region: NlpE; pfam04170
857087001385	NAD synthetase; Provisional; Region: PRK13981
857087001386	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
857087001387	multimer interface [polypeptide binding]; other site
857087001388	active site
857087001389	catalytic triad [active]
857087001390	protein interface 1 [polypeptide binding]; other site
857087001391	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
857087001392	homodimer interface [polypeptide binding]; other site
857087001393	NAD binding pocket [chemical binding]; other site
857087001394	ATP binding pocket [chemical binding]; other site
857087001395	Mg binding site [ion binding]; other site
857087001396	active-site loop [active]
857087001397	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
857087001398	CoA binding domain; Region: CoA_binding; smart00881
857087001399	CoA-ligase; Region: Ligase_CoA; pfam00549
857087001400	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
857087001401	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
857087001402	CoA-ligase; Region: Ligase_CoA; pfam00549
857087001403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087001404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087001405	dimer interface [polypeptide binding]; other site
857087001406	phosphorylation site [posttranslational modification]
857087001407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087001408	ATP binding site [chemical binding]; other site
857087001409	Mg2+ binding site [ion binding]; other site
857087001410	G-X-G motif; other site
857087001411	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087001412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087001413	active site
857087001414	phosphorylation site [posttranslational modification]
857087001415	intermolecular recognition site; other site
857087001416	dimerization interface [polypeptide binding]; other site
857087001417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087001418	Walker A motif; other site
857087001419	ATP binding site [chemical binding]; other site
857087001420	Walker B motif; other site
857087001421	arginine finger; other site
857087001422	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087001423	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087001424	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087001425	metal binding site [ion binding]; metal-binding site
857087001426	active site
857087001427	I-site; other site
857087001428	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087001429	HDOD domain; Region: HDOD; pfam08668
857087001430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
857087001431	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
857087001432	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
857087001433	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087001434	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087001435	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087001436	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087001437	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
857087001438	amphipathic channel; other site
857087001439	Asn-Pro-Ala signature motifs; other site
857087001440	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
857087001441	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
857087001442	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
857087001443	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
857087001444	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
857087001445	active site
857087001446	Uncharacterized conserved protein [Function unknown]; Region: COG2308
857087001447	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
857087001448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
857087001449	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
857087001450	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
857087001451	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087001452	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
857087001453	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087001454	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
857087001455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
857087001456	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
857087001457	PgaD-like protein; Region: PgaD; pfam13994
857087001458	N-glycosyltransferase; Provisional; Region: PRK11204
857087001459	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
857087001460	DXD motif; other site
857087001461	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
857087001462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
857087001463	TPR motif; other site
857087001464	binding surface
857087001465	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
857087001466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001467	TPR motif; other site
857087001468	binding surface
857087001469	Autotransporter beta-domain; Region: Autotransporter; cl17461
857087001470	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
857087001471	ligand binding surface [chemical binding]; other site
857087001472	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
857087001473	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
857087001474	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
857087001475	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
857087001476	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
857087001477	heme binding site [chemical binding]; other site
857087001478	ferroxidase pore; other site
857087001479	ferroxidase diiron center [ion binding]; other site
857087001480	heat shock protein 90; Provisional; Region: PRK05218
857087001481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087001482	ATP binding site [chemical binding]; other site
857087001483	Mg2+ binding site [ion binding]; other site
857087001484	G-X-G motif; other site
857087001485	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
857087001486	HD domain; Region: HD_4; pfam13328
857087001487	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
857087001488	synthetase active site [active]
857087001489	NTP binding site [chemical binding]; other site
857087001490	metal binding site [ion binding]; metal-binding site
857087001491	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
857087001492	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
857087001493	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087001494	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087001495	catalytic residue [active]
857087001496	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087001497	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
857087001498	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087001499	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
857087001500	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087001501	Methyltransferase domain; Region: Methyltransf_11; pfam08241
857087001502	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
857087001503	RNA/DNA hybrid binding site [nucleotide binding]; other site
857087001504	active site
857087001505	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
857087001506	GIY-YIG motif/motif A; other site
857087001507	putative active site [active]
857087001508	putative metal binding site [ion binding]; other site
857087001509	Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087
857087001510	Rho binding site 1 [polypeptide binding]; other site
857087001511	putative Rho binding site 2 [polypeptide binding]; other site
857087001512	FMN-binding domain; Region: FMN_bind; pfam04205
857087001513	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
857087001514	metal binding site [ion binding]; metal-binding site
857087001515	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
857087001516	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
857087001517	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
857087001518	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
857087001519	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
857087001520	dimer interface [polypeptide binding]; other site
857087001521	putative metal binding site [ion binding]; other site
857087001522	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
857087001523	TrkA-N domain; Region: TrkA_N; pfam02254
857087001524	TrkA-C domain; Region: TrkA_C; pfam02080
857087001525	TrkA-N domain; Region: TrkA_N; pfam02254
857087001526	TrkA-C domain; Region: TrkA_C; pfam02080
857087001527	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
857087001528	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
857087001529	putative ADP-binding pocket [chemical binding]; other site
857087001530	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
857087001531	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
857087001532	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
857087001533	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
857087001534	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
857087001535	putative substrate binding site [chemical binding]; other site
857087001536	putative ATP binding site [chemical binding]; other site
857087001537	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087001538	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087001539	putative active site [active]
857087001540	putative NTP binding site [chemical binding]; other site
857087001541	putative nucleic acid binding site [nucleotide binding]; other site
857087001542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087001543	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
857087001544	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
857087001545	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
857087001546	putative coenzyme Q binding site [chemical binding]; other site
857087001547	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
857087001548	Na2 binding site [ion binding]; other site
857087001549	putative substrate binding site 1 [chemical binding]; other site
857087001550	Na binding site 1 [ion binding]; other site
857087001551	putative substrate binding site 2 [chemical binding]; other site
857087001552	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
857087001553	SmpB-tmRNA interface; other site
857087001554	Isochorismatase family; Region: Isochorismatase; pfam00857
857087001555	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
857087001556	catalytic triad [active]
857087001557	dimer interface [polypeptide binding]; other site
857087001558	conserved cis-peptide bond; other site
857087001559	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
857087001560	ApbE family; Region: ApbE; pfam02424
857087001561	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
857087001562	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
857087001563	active site
857087001564	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
857087001565	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
857087001566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087001567	catalytic residue [active]
857087001568	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
857087001569	substrate binding site [chemical binding]; other site
857087001570	active site
857087001571	catalytic residues [active]
857087001572	heterodimer interface [polypeptide binding]; other site
857087001573	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
857087001574	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
857087001575	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
857087001576	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
857087001577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
857087001578	Sporulation related domain; Region: SPOR; pfam05036
857087001579	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
857087001580	Colicin V production protein; Region: Colicin_V; cl00567
857087001581	amidophosphoribosyltransferase; Provisional; Region: PRK09246
857087001582	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
857087001583	active site
857087001584	tetramer interface [polypeptide binding]; other site
857087001585	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087001586	active site
857087001587	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
857087001588	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
857087001589	homodimer interface [polypeptide binding]; other site
857087001590	substrate-cofactor binding pocket; other site
857087001591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087001592	catalytic residue [active]
857087001593	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087001594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087001595	metal binding site [ion binding]; metal-binding site
857087001596	active site
857087001597	I-site; other site
857087001598	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087001599	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
857087001600	GSH binding site [chemical binding]; other site
857087001601	catalytic residues [active]
857087001602	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
857087001603	active site
857087001604	Zn2+ binding site [ion binding]; other site
857087001605	hypothetical protein; Provisional; Region: PRK11281
857087001606	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
857087001607	Mechanosensitive ion channel; Region: MS_channel; pfam00924
857087001608	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
857087001609	ATP cone domain; Region: ATP-cone; pfam03477
857087001610	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
857087001611	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
857087001612	catalytic motif [active]
857087001613	Zn binding site [ion binding]; other site
857087001614	RibD C-terminal domain; Region: RibD_C; cl17279
857087001615	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
857087001616	Lumazine binding domain; Region: Lum_binding; pfam00677
857087001617	Lumazine binding domain; Region: Lum_binding; pfam00677
857087001618	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
857087001619	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
857087001620	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
857087001621	dimerization interface [polypeptide binding]; other site
857087001622	active site
857087001623	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
857087001624	homopentamer interface [polypeptide binding]; other site
857087001625	active site
857087001626	transcription antitermination factor NusB; Region: nusB; TIGR01951
857087001627	putative RNA binding site [nucleotide binding]; other site
857087001628	thiamine monophosphate kinase; Provisional; Region: PRK05731
857087001629	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
857087001630	ATP binding site [chemical binding]; other site
857087001631	dimerization interface [polypeptide binding]; other site
857087001632	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
857087001633	tetramer interfaces [polypeptide binding]; other site
857087001634	binuclear metal-binding site [ion binding]; other site
857087001635	Domain of unknown function (DUF336); Region: DUF336; cl01249
857087001636	Ribosome-binding factor A; Region: RBFA; cl00542
857087001637	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
857087001638	hypothetical protein; Reviewed; Region: PRK09588
857087001639	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
857087001640	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
857087001641	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
857087001642	active site
857087001643	tetramer interface; other site
857087001644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
857087001645	Histidine kinase; Region: HisKA_3; pfam07730
857087001646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087001647	ATP binding site [chemical binding]; other site
857087001648	Mg2+ binding site [ion binding]; other site
857087001649	G-X-G motif; other site
857087001650	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
857087001651	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
857087001652	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
857087001653	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
857087001654	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
857087001655	nucleotide binding site/active site [active]
857087001656	HIT family signature motif; other site
857087001657	catalytic residue [active]
857087001658	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
857087001659	CrcB-like protein; Region: CRCB; cl09114
857087001660	GTPase RsgA; Reviewed; Region: PRK00098
857087001661	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
857087001662	RNA binding site [nucleotide binding]; other site
857087001663	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
857087001664	GTPase/Zn-binding domain interface [polypeptide binding]; other site
857087001665	GTP/Mg2+ binding site [chemical binding]; other site
857087001666	G4 box; other site
857087001667	G5 box; other site
857087001668	G1 box; other site
857087001669	Switch I region; other site
857087001670	G2 box; other site
857087001671	G3 box; other site
857087001672	Switch II region; other site
857087001673	Peptidase family M48; Region: Peptidase_M48; pfam01435
857087001674	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
857087001675	catalytic site [active]
857087001676	putative active site [active]
857087001677	putative substrate binding site [chemical binding]; other site
857087001678	dimer interface [polypeptide binding]; other site
857087001679	seryl-tRNA synthetase; Provisional; Region: PRK05431
857087001680	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
857087001681	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
857087001682	dimer interface [polypeptide binding]; other site
857087001683	active site
857087001684	motif 1; other site
857087001685	motif 2; other site
857087001686	motif 3; other site
857087001687	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
857087001688	apolar tunnel; other site
857087001689	heme binding site [chemical binding]; other site
857087001690	dimerization interface [polypeptide binding]; other site
857087001691	Transposase; Region: HTH_Tnp_1; cl17663
857087001692	putative transposase OrfB; Reviewed; Region: PHA02517
857087001693	Homeodomain-like domain; Region: HTH_32; pfam13565
857087001694	Integrase core domain; Region: rve; pfam00665
857087001695	Integrase core domain; Region: rve_3; pfam13683
857087001696	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
857087001697	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
857087001698	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
857087001699	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
857087001700	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
857087001701	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
857087001702	active site
857087001703	dimer interface [polypeptide binding]; other site
857087001704	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
857087001705	dimer interface [polypeptide binding]; other site
857087001706	active site
857087001707	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
857087001708	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
857087001709	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087001710	active site
857087001711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087001712	active site
857087001713	ATP binding site [chemical binding]; other site
857087001714	substrate binding site [chemical binding]; other site
857087001715	activation loop (A-loop); other site
857087001716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087001717	putative substrate translocation pore; other site
857087001718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087001719	EthD domain; Region: EthD; cl17553
857087001720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087001721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087001722	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
857087001723	dimerization interface [polypeptide binding]; other site
857087001724	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
857087001725	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
857087001726	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
857087001727	putative active site [active]
857087001728	putative metal binding site [ion binding]; other site
857087001729	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
857087001730	PhoU domain; Region: PhoU; pfam01895
857087001731	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
857087001732	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
857087001733	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
857087001734	Clp amino terminal domain; Region: Clp_N; pfam02861
857087001735	Clp amino terminal domain; Region: Clp_N; pfam02861
857087001736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087001737	Walker A motif; other site
857087001738	ATP binding site [chemical binding]; other site
857087001739	Walker B motif; other site
857087001740	arginine finger; other site
857087001741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087001742	Walker A motif; other site
857087001743	ATP binding site [chemical binding]; other site
857087001744	Walker B motif; other site
857087001745	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
857087001746	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087001747	DNA-binding site [nucleotide binding]; DNA binding site
857087001748	RNA-binding motif; other site
857087001749	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087001750	Radical SAM superfamily; Region: Radical_SAM; pfam04055
857087001751	FeS/SAM binding site; other site
857087001752	FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980
857087001753	putative subunit interface; other site
857087001754	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
857087001755	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
857087001756	FTR, proximal lobe; Region: FTR_C; pfam02741
857087001757	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
857087001758	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
857087001759	active site
857087001760	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
857087001761	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
857087001762	putative [4Fe-4S] binding site [ion binding]; other site
857087001763	putative molybdopterin cofactor binding site [chemical binding]; other site
857087001764	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
857087001765	aromatic arch; other site
857087001766	DCoH dimer interaction site [polypeptide binding]; other site
857087001767	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
857087001768	DCoH tetramer interaction site [polypeptide binding]; other site
857087001769	substrate binding site [chemical binding]; other site
857087001770	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
857087001771	stringent starvation protein A; Provisional; Region: sspA; PRK09481
857087001772	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087001773	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
857087001774	dimer interface [polypeptide binding]; other site
857087001775	N-terminal domain interface [polypeptide binding]; other site
857087001776	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
857087001777	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
857087001778	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
857087001779	Qi binding site; other site
857087001780	intrachain domain interface; other site
857087001781	interchain domain interface [polypeptide binding]; other site
857087001782	heme bH binding site [chemical binding]; other site
857087001783	heme bL binding site [chemical binding]; other site
857087001784	Qo binding site; other site
857087001785	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
857087001786	interchain domain interface [polypeptide binding]; other site
857087001787	intrachain domain interface; other site
857087001788	Qi binding site; other site
857087001789	Qo binding site; other site
857087001790	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
857087001791	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
857087001792	[2Fe-2S] cluster binding site [ion binding]; other site
857087001793	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
857087001794	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087001795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087001796	homodimer interface [polypeptide binding]; other site
857087001797	catalytic residue [active]
857087001798	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
857087001799	amino acid carrier protein; Region: agcS; TIGR00835
857087001800	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
857087001801	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
857087001802	putative active site [active]
857087001803	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
857087001804	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
857087001805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001806	TPR motif; other site
857087001807	binding surface
857087001808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001809	binding surface
857087001810	TPR motif; other site
857087001811	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087001812	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087001813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001814	TPR motif; other site
857087001815	binding surface
857087001816	TPR repeat; Region: TPR_11; pfam13414
857087001817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
857087001818	binding surface
857087001819	TPR motif; other site
857087001820	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
857087001821	TPR repeat; Region: TPR_11; pfam13414
857087001822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001823	binding surface
857087001824	TPR motif; other site
857087001825	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001826	TPR motif; other site
857087001827	TPR repeat; Region: TPR_11; pfam13414
857087001828	binding surface
857087001829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001830	binding surface
857087001831	TPR motif; other site
857087001832	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
857087001833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001834	binding surface
857087001835	TPR motif; other site
857087001836	TPR repeat; Region: TPR_11; pfam13414
857087001837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087001838	binding surface
857087001839	TPR motif; other site
857087001840	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087001841	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
857087001842	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
857087001843	Transposase; Region: HTH_Tnp_1; cl17663
857087001844	putative transposase OrfB; Reviewed; Region: PHA02517
857087001845	HTH-like domain; Region: HTH_21; pfam13276
857087001846	Integrase core domain; Region: rve; pfam00665
857087001847	Integrase core domain; Region: rve_3; pfam13683
857087001848	Predicted transcriptional regulator [Transcription]; Region: COG2944
857087001849	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087001850	non-specific DNA binding site [nucleotide binding]; other site
857087001851	salt bridge; other site
857087001852	sequence-specific DNA binding site [nucleotide binding]; other site
857087001853	Protein of unknown function (DUF497); Region: DUF497; cl01108
857087001854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
857087001855	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
857087001856	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
857087001857	NAD binding site [chemical binding]; other site
857087001858	dimerization interface [polypeptide binding]; other site
857087001859	product binding site; other site
857087001860	substrate binding site [chemical binding]; other site
857087001861	zinc binding site [ion binding]; other site
857087001862	catalytic residues [active]
857087001863	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
857087001864	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
857087001865	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
857087001866	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
857087001867	hinge; other site
857087001868	active site
857087001869	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
857087001870	anti sigma factor interaction site; other site
857087001871	regulatory phosphorylation site [posttranslational modification]; other site
857087001872	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
857087001873	mce related protein; Region: MCE; pfam02470
857087001874	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
857087001875	Permease; Region: Permease; cl00510
857087001876	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
857087001877	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
857087001878	Walker A/P-loop; other site
857087001879	ATP binding site [chemical binding]; other site
857087001880	Q-loop/lid; other site
857087001881	ABC transporter signature motif; other site
857087001882	Walker B; other site
857087001883	D-loop; other site
857087001884	H-loop/switch region; other site
857087001885	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
857087001886	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
857087001887	putative active site [active]
857087001888	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
857087001889	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
857087001890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087001891	active site
857087001892	motif I; other site
857087001893	motif II; other site
857087001894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
857087001895	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
857087001896	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
857087001897	OstA-like protein; Region: OstA; pfam03968
857087001898	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
857087001899	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
857087001900	Walker A/P-loop; other site
857087001901	ATP binding site [chemical binding]; other site
857087001902	Q-loop/lid; other site
857087001903	ABC transporter signature motif; other site
857087001904	Walker B; other site
857087001905	D-loop; other site
857087001906	H-loop/switch region; other site
857087001907	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
857087001908	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
857087001909	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
857087001910	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
857087001911	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
857087001912	30S subunit binding site; other site
857087001913	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
857087001914	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
857087001915	MgtE intracellular N domain; Region: MgtE_N; smart00924
857087001916	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
857087001917	Divalent cation transporter; Region: MgtE; cl00786
857087001918	septum formation inhibitor; Reviewed; Region: minC; PRK00339
857087001919	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
857087001920	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
857087001921	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
857087001922	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
857087001923	Switch I; other site
857087001924	Switch II; other site
857087001925	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
857087001926	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
857087001927	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
857087001928	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
857087001929	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
857087001930	Ligand binding site; other site
857087001931	DXD motif; other site
857087001932	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
857087001933	ATP binding site [chemical binding]; other site
857087001934	active site
857087001935	substrate binding site [chemical binding]; other site
857087001936	Protein of unknown function (DUF770); Region: DUF770; cl01402
857087001937	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
857087001938	Autotransporter beta-domain; Region: Autotransporter; smart00869
857087001939	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
857087001940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087001941	FeS/SAM binding site; other site
857087001942	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
857087001943	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
857087001944	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
857087001945	putative active site [active]
857087001946	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
857087001947	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
857087001948	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
857087001949	coenzyme PQQ precursor peptide PqqA; Region: PQQ_syn_pqqA; TIGR02107
857087001950	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
857087001951	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
857087001952	Poly A polymerase head domain; Region: PolyA_pol; pfam01743
857087001953	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
857087001954	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087001955	Zn2+ binding site [ion binding]; other site
857087001956	Mg2+ binding site [ion binding]; other site
857087001957	Protein of unknown function, DUF486; Region: DUF486; cl01236
857087001958	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
857087001959	protease TldD; Provisional; Region: tldD; PRK10735
857087001960	peptidase PmbA; Provisional; Region: PRK11040
857087001961	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
857087001962	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
857087001963	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087001964	Zn2+ binding site [ion binding]; other site
857087001965	Mg2+ binding site [ion binding]; other site
857087001966	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
857087001967	DNA binding residues [nucleotide binding]
857087001968	dimerization interface [polypeptide binding]; other site
857087001969	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087001970	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087001971	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087001972	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087001973	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
857087001974	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
857087001975	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
857087001976	quinone interaction residues [chemical binding]; other site
857087001977	active site
857087001978	catalytic residues [active]
857087001979	FMN binding site [chemical binding]; other site
857087001980	substrate binding site [chemical binding]; other site
857087001981	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
857087001982	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
857087001983	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
857087001984	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
857087001985	TAP-like protein; Region: Abhydrolase_4; pfam08386
857087001986	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
857087001987	Flavoprotein; Region: Flavoprotein; pfam02441
857087001988	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
857087001989	phosphate binding site [ion binding]; other site
857087001990	transketolase; Reviewed; Region: PRK12753
857087001991	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
857087001992	TPP-binding site [chemical binding]; other site
857087001993	dimer interface [polypeptide binding]; other site
857087001994	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
857087001995	PYR/PP interface [polypeptide binding]; other site
857087001996	dimer interface [polypeptide binding]; other site
857087001997	TPP binding site [chemical binding]; other site
857087001998	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
857087001999	pteridine reductase; Provisional; Region: PRK09135
857087002000	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
857087002001	NADP binding site [chemical binding]; other site
857087002002	substrate binding pocket [chemical binding]; other site
857087002003	active site
857087002004	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
857087002005	catalytic center binding site [active]
857087002006	ATP binding site [chemical binding]; other site
857087002007	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
857087002008	homooctamer interface [polypeptide binding]; other site
857087002009	active site
857087002010	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
857087002011	UGMP family protein; Validated; Region: PRK09604
857087002012	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
857087002013	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
857087002014	Yqey-like protein; Region: YqeY; pfam09424
857087002015	DNA primase; Validated; Region: dnaG; PRK05667
857087002016	CHC2 zinc finger; Region: zf-CHC2; pfam01807
857087002017	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
857087002018	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
857087002019	active site
857087002020	metal binding site [ion binding]; metal-binding site
857087002021	interdomain interaction site; other site
857087002022	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
857087002023	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
857087002024	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
857087002025	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
857087002026	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
857087002027	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
857087002028	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087002029	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
857087002030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087002031	DNA binding residues [nucleotide binding]
857087002032	S-adenosylmethionine synthetase; Validated; Region: PRK05250
857087002033	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
857087002034	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
857087002035	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
857087002036	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
857087002037	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
857087002038	homotetramer interface [polypeptide binding]; other site
857087002039	ligand binding site [chemical binding]; other site
857087002040	catalytic site [active]
857087002041	NAD binding site [chemical binding]; other site
857087002042	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
857087002043	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
857087002044	inhibitor-cofactor binding pocket; inhibition site
857087002045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087002046	catalytic residue [active]
857087002047	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
857087002048	RNA methyltransferase, RsmE family; Region: TIGR00046
857087002049	CAAX protease self-immunity; Region: Abi; pfam02517
857087002050	Ecdysteroid kinase; Region: EcKinase; cl17738
857087002051	Phosphotransferase enzyme family; Region: APH; pfam01636
857087002052	aspartate kinase; Reviewed; Region: PRK06635
857087002053	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
857087002054	putative nucleotide binding site [chemical binding]; other site
857087002055	putative catalytic residues [active]
857087002056	putative Mg ion binding site [ion binding]; other site
857087002057	putative aspartate binding site [chemical binding]; other site
857087002058	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
857087002059	putative allosteric regulatory site; other site
857087002060	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
857087002061	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
857087002062	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
857087002063	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
857087002064	Fic family protein [Function unknown]; Region: COG3177
857087002065	Fic/DOC family; Region: Fic; pfam02661
857087002066	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
857087002067	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
857087002068	PEP-CTERM motif; Region: VPEP; pfam07589
857087002069	putative transposase OrfB; Reviewed; Region: PHA02517
857087002070	Homeodomain-like domain; Region: HTH_32; pfam13565
857087002071	Integrase core domain; Region: rve; pfam00665
857087002072	Integrase core domain; Region: rve_3; pfam13683
857087002073	Transposase; Region: HTH_Tnp_1; cl17663
857087002074	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
857087002075	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
857087002076	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087002077	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087002078	Cell division protein ZapA; Region: ZapA; pfam05164
857087002079	TIGR02449 family protein; Region: TIGR02449
857087002080	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
857087002081	proline aminopeptidase P II; Provisional; Region: PRK10879
857087002082	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
857087002083	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
857087002084	active site
857087002085	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
857087002086	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
857087002087	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
857087002088	catalytic core [active]
857087002089	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
857087002090	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
857087002091	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
857087002092	SEC-C motif; Region: SEC-C; pfam02810
857087002093	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
857087002094	homodimer interface [polypeptide binding]; other site
857087002095	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
857087002096	active site pocket [active]
857087002097	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
857087002098	putative transposase OrfB; Reviewed; Region: PHA02517
857087002099	Homeodomain-like domain; Region: HTH_32; pfam13565
857087002100	Integrase core domain; Region: rve; pfam00665
857087002101	Integrase core domain; Region: rve_3; pfam13683
857087002102	Transposase; Region: HTH_Tnp_1; cl17663
857087002103	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
857087002104	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
857087002105	active site residue [active]
857087002106	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
857087002107	active site residue [active]
857087002108	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
857087002109	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
857087002110	NAD(P) binding site [chemical binding]; other site
857087002111	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
857087002112	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
857087002113	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
857087002114	putative peptidase; Provisional; Region: PRK11649
857087002115	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
857087002116	Peptidase family M23; Region: Peptidase_M23; pfam01551
857087002117	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
857087002118	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
857087002119	active site
857087002120	HIGH motif; other site
857087002121	dimer interface [polypeptide binding]; other site
857087002122	KMSKS motif; other site
857087002123	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087002124	RNA binding surface [nucleotide binding]; other site
857087002125	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
857087002126	PGAP1-like protein; Region: PGAP1; pfam07819
857087002127	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
857087002128	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
857087002129	active site
857087002130	ADP/pyrophosphate binding site [chemical binding]; other site
857087002131	allosteric effector site; other site
857087002132	dimerization interface [polypeptide binding]; other site
857087002133	fructose-1,6-bisphosphate binding site; other site
857087002134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
857087002135	SnoaL-like domain; Region: SnoaL_2; pfam12680
857087002136	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087002137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087002138	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
857087002139	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
857087002140	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
857087002141	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
857087002142	Soluble P-type ATPase [General function prediction only]; Region: COG4087
857087002143	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
857087002144	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
857087002145	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
857087002146	ATP binding site [chemical binding]; other site
857087002147	substrate interface [chemical binding]; other site
857087002148	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
857087002149	oligomerisation interface [polypeptide binding]; other site
857087002150	mobile loop; other site
857087002151	roof hairpin; other site
857087002152	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
857087002153	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
857087002154	ring oligomerisation interface [polypeptide binding]; other site
857087002155	ATP/Mg binding site [chemical binding]; other site
857087002156	stacking interactions; other site
857087002157	hinge regions; other site
857087002158	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
857087002159	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087002160	active site
857087002161	ATP binding site [chemical binding]; other site
857087002162	substrate binding site [chemical binding]; other site
857087002163	activation loop (A-loop); other site
857087002164	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
857087002165	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087002166	phosphopeptide binding site; other site
857087002167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002169	metal binding site [ion binding]; metal-binding site
857087002170	active site
857087002171	I-site; other site
857087002172	Spondin_N; Region: Spond_N; pfam06468
857087002173	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
857087002174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087002175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087002176	dimerization interface [polypeptide binding]; other site
857087002177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087002178	dimer interface [polypeptide binding]; other site
857087002179	phosphorylation site [posttranslational modification]
857087002180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087002181	ATP binding site [chemical binding]; other site
857087002182	Mg2+ binding site [ion binding]; other site
857087002183	G-X-G motif; other site
857087002184	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087002185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002186	active site
857087002187	phosphorylation site [posttranslational modification]
857087002188	intermolecular recognition site; other site
857087002189	dimerization interface [polypeptide binding]; other site
857087002190	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087002191	DNA binding site [nucleotide binding]
857087002192	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
857087002193	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
857087002194	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
857087002195	Cation transport protein; Region: TrkH; cl17365
857087002196	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
857087002197	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
857087002198	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
857087002199	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
857087002200	Predicted permeases [General function prediction only]; Region: COG0679
857087002201	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
857087002202	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
857087002203	putative MPT binding site; other site
857087002204	ABC transporter ATPase component; Reviewed; Region: PRK11147
857087002205	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087002206	Walker A/P-loop; other site
857087002207	ATP binding site [chemical binding]; other site
857087002208	Q-loop/lid; other site
857087002209	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087002210	ABC transporter signature motif; other site
857087002211	Walker B; other site
857087002212	ABC transporter; Region: ABC_tran_2; pfam12848
857087002213	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087002214	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
857087002215	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
857087002216	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087002217	Zn2+ binding site [ion binding]; other site
857087002218	Mg2+ binding site [ion binding]; other site
857087002219	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
857087002220	Phosphoglycerate kinase; Region: PGK; pfam00162
857087002221	substrate binding site [chemical binding]; other site
857087002222	hinge regions; other site
857087002223	ADP binding site [chemical binding]; other site
857087002224	catalytic site [active]
857087002225	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
857087002226	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
857087002227	metal binding triad; other site
857087002228	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
857087002229	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
857087002230	metal binding triad; other site
857087002231	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
857087002232	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
857087002233	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
857087002234	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087002235	Transposase; Region: HTH_Tnp_1; pfam01527
857087002236	putative transposase OrfB; Reviewed; Region: PHA02517
857087002237	HTH-like domain; Region: HTH_21; pfam13276
857087002238	Integrase core domain; Region: rve; pfam00665
857087002239	Integrase core domain; Region: rve_3; pfam13683
857087002240	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
857087002241	Mechanosensitive ion channel; Region: MS_channel; pfam00924
857087002242	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
857087002243	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087002244	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
857087002245	alpha subunit interaction interface [polypeptide binding]; other site
857087002246	Walker A motif; other site
857087002247	ATP binding site [chemical binding]; other site
857087002248	Walker B motif; other site
857087002249	inhibitor binding site; inhibition site
857087002250	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
857087002251	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
857087002252	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
857087002253	epsilon subunit interface [polypeptide binding]; other site
857087002254	LBP interface [polypeptide binding]; other site
857087002255	gamma subunit interface [polypeptide binding]; other site
857087002256	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
857087002257	ATP synthase A chain; Region: ATP-synt_A; cl00413
857087002258	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
857087002259	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
857087002260	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
857087002261	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087002262	Walker A motif; other site
857087002263	ATP binding site [chemical binding]; other site
857087002264	Walker B motif; other site
857087002265	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
857087002266	delta subunit interface [polypeptide binding]; other site
857087002267	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087002268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002269	active site
857087002270	phosphorylation site [posttranslational modification]
857087002271	intermolecular recognition site; other site
857087002272	dimerization interface [polypeptide binding]; other site
857087002273	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
857087002274	putative binding surface; other site
857087002275	active site
857087002276	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
857087002277	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
857087002278	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
857087002279	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
857087002280	Protein of unknown function (DUF877); Region: DUF877; pfam05943
857087002281	Protein of unknown function (DUF796); Region: DUF796; pfam05638
857087002282	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
857087002283	ImpE protein; Region: ImpE; pfam07024
857087002284	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
857087002285	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
857087002286	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
857087002287	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
857087002288	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
857087002289	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002290	Walker A motif; other site
857087002291	ATP binding site [chemical binding]; other site
857087002292	Walker B motif; other site
857087002293	arginine finger; other site
857087002294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002295	Walker A motif; other site
857087002296	ATP binding site [chemical binding]; other site
857087002297	Walker B motif; other site
857087002298	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
857087002299	Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007
857087002300	putative active site [active]
857087002301	putative Zn binding site [ion binding]; other site
857087002302	Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007
857087002303	putative active site [active]
857087002304	putative Zn binding site [ion binding]; other site
857087002305	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
857087002306	TPR repeat; Region: TPR_11; pfam13414
857087002307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002308	binding surface
857087002309	TPR motif; other site
857087002310	Tetratricopeptide repeat; Region: TPR_12; pfam13424
857087002311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002312	TPR motif; other site
857087002313	binding surface
857087002314	Tetratricopeptide repeat; Region: TPR_12; pfam13424
857087002315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002316	binding surface
857087002317	TPR motif; other site
857087002318	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
857087002319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087002320	S-adenosylmethionine binding site [chemical binding]; other site
857087002321	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
857087002322	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
857087002323	dimerization interface [polypeptide binding]; other site
857087002324	putative ATP binding site [chemical binding]; other site
857087002325	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
857087002326	tartrate dehydrogenase; Region: TTC; TIGR02089
857087002327	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
857087002328	(R)-citramalate synthase; Provisional; Region: PRK09389
857087002329	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
857087002330	active site
857087002331	catalytic residues [active]
857087002332	metal binding site [ion binding]; metal-binding site
857087002333	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
857087002334	Homeodomain-like domain; Region: HTH_23; pfam13384
857087002335	Winged helix-turn helix; Region: HTH_29; pfam13551
857087002336	Homeodomain-like domain; Region: HTH_32; pfam13565
857087002337	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087002338	glycogen branching enzyme; Provisional; Region: PRK05402
857087002339	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
857087002340	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
857087002341	active site
857087002342	catalytic site [active]
857087002343	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
857087002344	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
857087002345	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
857087002346	active site
857087002347	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
857087002348	Dynamin family; Region: Dynamin_N; pfam00350
857087002349	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
857087002350	G1 box; other site
857087002351	GTP/Mg2+ binding site [chemical binding]; other site
857087002352	G2 box; other site
857087002353	Switch I region; other site
857087002354	G3 box; other site
857087002355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
857087002356	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
857087002357	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
857087002358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002359	active site
857087002360	phosphorylation site [posttranslational modification]
857087002361	intermolecular recognition site; other site
857087002362	dimerization interface [polypeptide binding]; other site
857087002363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002364	Walker A motif; other site
857087002365	ATP binding site [chemical binding]; other site
857087002366	Walker B motif; other site
857087002367	arginine finger; other site
857087002368	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087002369	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
857087002370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002371	putative active site [active]
857087002372	heme pocket [chemical binding]; other site
857087002373	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
857087002374	dimer interface [polypeptide binding]; other site
857087002375	phosphorylation site [posttranslational modification]
857087002376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087002377	ATP binding site [chemical binding]; other site
857087002378	Mg2+ binding site [ion binding]; other site
857087002379	G-X-G motif; other site
857087002380	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
857087002381	SlyX; Region: SlyX; pfam04102
857087002382	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
857087002383	homoserine O-succinyltransferase; Provisional; Region: PRK05368
857087002384	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
857087002385	conserved cys residue [active]
857087002386	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
857087002387	nucleoside/Zn binding site; other site
857087002388	dimer interface [polypeptide binding]; other site
857087002389	catalytic motif [active]
857087002390	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
857087002391	active site
857087002392	HslU subunit interaction site [polypeptide binding]; other site
857087002393	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
857087002394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002395	Walker A motif; other site
857087002396	ATP binding site [chemical binding]; other site
857087002397	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
857087002398	Walker B motif; other site
857087002399	arginine finger; other site
857087002400	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
857087002401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
857087002402	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
857087002403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087002404	S-adenosylmethionine binding site [chemical binding]; other site
857087002405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
857087002406	SCP-2 sterol transfer family; Region: SCP2; pfam02036
857087002407	ABC1 family; Region: ABC1; cl17513
857087002408	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
857087002409	2-isopropylmalate synthase; Validated; Region: PRK00915
857087002410	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
857087002411	active site
857087002412	catalytic residues [active]
857087002413	metal binding site [ion binding]; metal-binding site
857087002414	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
857087002415	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
857087002416	Fe-S cluster binding site [ion binding]; other site
857087002417	active site
857087002418	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
857087002419	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087002420	Coenzyme A binding pocket [chemical binding]; other site
857087002421	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
857087002422	type II secretion system protein D; Region: type_II_gspD; TIGR02517
857087002423	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087002424	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087002425	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087002426	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
857087002427	type II secretion system protein E; Region: type_II_gspE; TIGR02533
857087002428	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
857087002429	Walker A motif; other site
857087002430	ATP binding site [chemical binding]; other site
857087002431	Walker B motif; other site
857087002432	type II secretion system protein F; Region: GspF; TIGR02120
857087002433	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087002434	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087002435	Predicted membrane protein [Function unknown]; Region: COG4325
857087002436	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
857087002437	BON domain; Region: BON; pfam04972
857087002438	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
857087002439	Mechanosensitive ion channel; Region: MS_channel; pfam00924
857087002440	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
857087002441	Peptidase C26; Region: Peptidase_C26; pfam07722
857087002442	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
857087002443	catalytic triad [active]
857087002444	Predicted membrane protein [Function unknown]; Region: COG1238
857087002445	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
857087002446	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
857087002447	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
857087002448	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
857087002449	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
857087002450	type II secretion system protein I; Region: gspI; TIGR01707
857087002451	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
857087002452	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
857087002453	type II secretion system protein J; Region: gspJ; TIGR01711
857087002454	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
857087002455	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
857087002456	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
857087002457	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
857087002458	GspL periplasmic domain; Region: GspL_C; cl14909
857087002459	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
857087002460	PEP-CTERM motif; Region: VPEP; pfam07589
857087002461	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
857087002462	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
857087002463	Surface antigen; Region: Bac_surface_Ag; pfam01103
857087002464	haemagglutination activity domain; Region: Haemagg_act; smart00912
857087002465	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
857087002466	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
857087002467	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
857087002468	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
857087002469	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
857087002470	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087002471	Gram-negative bacterial tonB protein; Region: TonB; cl10048
857087002472	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
857087002473	SurA N-terminal domain; Region: SurA_N; pfam09312
857087002474	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
857087002475	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
857087002476	organic solvent tolerance protein; Provisional; Region: PRK04423
857087002477	Organic solvent tolerance protein; Region: OstA_C; pfam04453
857087002478	Phosphotransferase enzyme family; Region: APH; pfam01636
857087002479	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
857087002480	active site
857087002481	ATP binding site [chemical binding]; other site
857087002482	substrate binding site [chemical binding]; other site
857087002483	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
857087002484	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
857087002485	Substrate binding site; other site
857087002486	metal-binding site
857087002487	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087002488	HSP70 interaction site [polypeptide binding]; other site
857087002489	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
857087002490	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
857087002491	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
857087002492	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
857087002493	nucleotide binding site [chemical binding]; other site
857087002494	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
857087002495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
857087002496	Protein of unknown function, DUF482; Region: DUF482; pfam04339
857087002497	Protein of unknown function (DUF938); Region: DUF938; pfam06080
857087002498	glutathionine S-transferase; Provisional; Region: PRK10542
857087002499	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
857087002500	C-terminal domain interface [polypeptide binding]; other site
857087002501	GSH binding site (G-site) [chemical binding]; other site
857087002502	dimer interface [polypeptide binding]; other site
857087002503	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
857087002504	N-terminal domain interface [polypeptide binding]; other site
857087002505	dimer interface [polypeptide binding]; other site
857087002506	substrate binding pocket (H-site) [chemical binding]; other site
857087002507	Hemerythrin; Region: Hemerythrin; cd12107
857087002508	Fe binding site [ion binding]; other site
857087002509	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
857087002510	CHAD domain; Region: CHAD; pfam05235
857087002511	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
857087002512	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
857087002513	Protein of unknown function (DUF2608); Region: DUF2608; pfam11019
857087002514	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
857087002515	ketol-acid reductoisomerase; Provisional; Region: PRK05479
857087002516	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
857087002517	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
857087002518	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
857087002519	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
857087002520	putative valine binding site [chemical binding]; other site
857087002521	dimer interface [polypeptide binding]; other site
857087002522	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
857087002523	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
857087002524	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
857087002525	PYR/PP interface [polypeptide binding]; other site
857087002526	dimer interface [polypeptide binding]; other site
857087002527	TPP binding site [chemical binding]; other site
857087002528	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
857087002529	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
857087002530	TPP-binding site [chemical binding]; other site
857087002531	dimer interface [polypeptide binding]; other site
857087002532	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
857087002533	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
857087002534	Walker A/P-loop; other site
857087002535	ATP binding site [chemical binding]; other site
857087002536	Q-loop/lid; other site
857087002537	ABC transporter signature motif; other site
857087002538	Walker B; other site
857087002539	D-loop; other site
857087002540	H-loop/switch region; other site
857087002541	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
857087002542	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
857087002543	ABC-ATPase subunit  interface; other site
857087002544	dimer interface [polypeptide binding]; other site
857087002545	putative PBP binding regions; other site
857087002546	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
857087002547	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
857087002548	putative hemin binding site; other site
857087002549	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
857087002550	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
857087002551	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
857087002552	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
857087002553	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087002554	N-terminal plug; other site
857087002555	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
857087002556	ligand-binding site [chemical binding]; other site
857087002557	Hemin uptake protein hemP; Region: hemP; pfam10636
857087002558	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
857087002559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087002560	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
857087002561	dimerization interface [polypeptide binding]; other site
857087002562	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
857087002563	catalytic triad [active]
857087002564	dimer interface [polypeptide binding]; other site
857087002565	glutathione reductase; Validated; Region: PRK06116
857087002566	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087002567	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
857087002568	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
857087002569	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
857087002570	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
857087002571	active site
857087002572	metal binding site [ion binding]; metal-binding site
857087002573	Cytochrome c [Energy production and conversion]; Region: COG3258
857087002574	Uncharacterized conserved protein [Function unknown]; Region: COG3461
857087002575	PAS domain; Region: PAS_9; pfam13426
857087002576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002577	putative active site [active]
857087002578	heme pocket [chemical binding]; other site
857087002579	PAS domain S-box; Region: sensory_box; TIGR00229
857087002580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002581	putative active site [active]
857087002582	heme pocket [chemical binding]; other site
857087002583	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002584	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002585	metal binding site [ion binding]; metal-binding site
857087002586	active site
857087002587	I-site; other site
857087002588	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
857087002589	putative active site [active]
857087002590	putative catalytic site [active]
857087002591	putative DNA binding site [nucleotide binding]; other site
857087002592	putative phosphate binding site [ion binding]; other site
857087002593	metal binding site A [ion binding]; metal-binding site
857087002594	putative AP binding site [nucleotide binding]; other site
857087002595	putative metal binding site B [ion binding]; other site
857087002596	GAF domain; Region: GAF; pfam01590
857087002597	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087002598	PAS domain S-box; Region: sensory_box; TIGR00229
857087002599	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002600	putative active site [active]
857087002601	heme pocket [chemical binding]; other site
857087002602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002603	PAS domain; Region: PAS_9; pfam13426
857087002604	putative active site [active]
857087002605	heme pocket [chemical binding]; other site
857087002606	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002607	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002608	metal binding site [ion binding]; metal-binding site
857087002609	active site
857087002610	I-site; other site
857087002611	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087002612	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
857087002613	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
857087002614	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087002615	dimerization interface [polypeptide binding]; other site
857087002616	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087002617	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087002618	dimer interface [polypeptide binding]; other site
857087002619	putative CheW interface [polypeptide binding]; other site
857087002620	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
857087002621	active site
857087002622	catalytic triad [active]
857087002623	oxyanion hole [active]
857087002624	switch loop; other site
857087002625	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
857087002626	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087002627	Walker A/P-loop; other site
857087002628	ATP binding site [chemical binding]; other site
857087002629	Q-loop/lid; other site
857087002630	ABC transporter signature motif; other site
857087002631	Walker B; other site
857087002632	D-loop; other site
857087002633	H-loop/switch region; other site
857087002634	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
857087002635	FtsX-like permease family; Region: FtsX; pfam02687
857087002636	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
857087002637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002638	Walker B motif; other site
857087002639	arginine finger; other site
857087002640	HDOD domain; Region: HDOD; pfam08668
857087002641	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
857087002642	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087002643	active site
857087002644	ATP binding site [chemical binding]; other site
857087002645	substrate binding site [chemical binding]; other site
857087002646	activation loop (A-loop); other site
857087002647	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087002648	phosphopeptide binding site; other site
857087002649	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087002650	metal ion-dependent adhesion site (MIDAS); other site
857087002651	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087002652	phosphopeptide binding site; other site
857087002653	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087002654	active site
857087002655	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002656	PAS fold; Region: PAS_3; pfam08447
857087002657	putative active site [active]
857087002658	heme pocket [chemical binding]; other site
857087002659	PAS domain S-box; Region: sensory_box; TIGR00229
857087002660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002661	putative active site [active]
857087002662	heme pocket [chemical binding]; other site
857087002663	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002664	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002665	metal binding site [ion binding]; metal-binding site
857087002666	active site
857087002667	I-site; other site
857087002668	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
857087002669	Nitrogen regulatory protein P-II; Region: P-II; smart00938
857087002670	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
857087002671	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087002672	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087002673	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087002674	Outer membrane efflux protein; Region: OEP; pfam02321
857087002675	Outer membrane efflux protein; Region: OEP; pfam02321
857087002676	Protein of unknown function DUF45; Region: DUF45; pfam01863
857087002677	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
857087002678	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
857087002679	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
857087002680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087002681	Walker A motif; other site
857087002682	ATP binding site [chemical binding]; other site
857087002683	Walker B motif; other site
857087002684	arginine finger; other site
857087002685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087002686	HTH domain; Region: HTH_11; cl17392
857087002687	Integrase core domain; Region: rve; pfam00665
857087002688	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
857087002689	active site
857087002690	DNA binding site [nucleotide binding]
857087002691	Int/Topo IB signature motif; other site
857087002692	Viral coat protein (S domain); Region: Viral_coat; pfam00729
857087002693	AAA domain; Region: AAA_25; pfam13481
857087002694	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087002695	Walker A motif; other site
857087002696	ATP binding site [chemical binding]; other site
857087002697	Walker B motif; other site
857087002698	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
857087002699	PilZ domain; Region: PilZ; pfam07238
857087002700	FlgN protein; Region: FlgN; pfam05130
857087002701	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
857087002702	SAF-like; Region: SAF_2; pfam13144
857087002703	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
857087002704	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
857087002705	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
857087002706	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087002707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002708	active site
857087002709	phosphorylation site [posttranslational modification]
857087002710	intermolecular recognition site; other site
857087002711	dimerization interface [polypeptide binding]; other site
857087002712	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
857087002713	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
857087002714	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
857087002715	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
857087002716	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
857087002717	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
857087002718	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
857087002719	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
857087002720	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
857087002721	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
857087002722	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
857087002723	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
857087002724	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
857087002725	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
857087002726	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
857087002727	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
857087002728	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
857087002729	Flagellar L-ring protein; Region: FlgH; pfam02107
857087002730	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
857087002731	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
857087002732	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
857087002733	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
857087002734	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
857087002735	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
857087002736	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
857087002737	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
857087002738	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
857087002739	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
857087002740	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
857087002741	catalytic residues [active]
857087002742	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
857087002743	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
857087002744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087002745	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087002746	non-specific DNA binding site [nucleotide binding]; other site
857087002747	salt bridge; other site
857087002748	sequence-specific DNA binding site [nucleotide binding]; other site
857087002749	Zonular occludens toxin (Zot); Region: Zot; cl17485
857087002750	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
857087002751	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
857087002752	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087002753	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087002754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087002755	Transposase; Region: HTH_Tnp_1; pfam01527
857087002756	putative transposase OrfB; Reviewed; Region: PHA02517
857087002757	HTH-like domain; Region: HTH_21; pfam13276
857087002758	Integrase core domain; Region: rve; pfam00665
857087002759	Integrase core domain; Region: rve_3; pfam13683
857087002760	Transglycosylase SLT domain; Region: SLT_2; pfam13406
857087002761	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087002762	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087002763	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
857087002764	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
857087002765	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
857087002766	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
857087002767	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
857087002768	rod shape-determining protein MreC; Provisional; Region: PRK13922
857087002769	rod shape-determining protein MreC; Region: MreC; pfam04085
857087002770	rod shape-determining protein MreB; Provisional; Region: PRK13927
857087002771	MreB and similar proteins; Region: MreB_like; cd10225
857087002772	nucleotide binding site [chemical binding]; other site
857087002773	Mg binding site [ion binding]; other site
857087002774	putative protofilament interaction site [polypeptide binding]; other site
857087002775	RodZ interaction site [polypeptide binding]; other site
857087002776	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
857087002777	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
857087002778	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
857087002779	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
857087002780	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
857087002781	GatB domain; Region: GatB_Yqey; smart00845
857087002782	AAA domain; Region: AAA_32; pfam13654
857087002783	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
857087002784	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
857087002785	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
857087002786	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
857087002787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002788	binding surface
857087002789	TPR motif; other site
857087002790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002791	TPR motif; other site
857087002792	binding surface
857087002793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
857087002794	TPR motif; other site
857087002795	binding surface
857087002796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002797	TPR motif; other site
857087002798	binding surface
857087002799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002800	TPR motif; other site
857087002801	binding surface
857087002802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002803	binding surface
857087002804	TPR motif; other site
857087002805	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087002806	TPR motif; other site
857087002807	binding surface
857087002808	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
857087002809	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
857087002810	CAP-like domain; other site
857087002811	active site
857087002812	primary dimer interface [polypeptide binding]; other site
857087002813	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087002814	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002815	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087002816	putative active site [active]
857087002817	heme pocket [chemical binding]; other site
857087002818	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002819	putative active site [active]
857087002820	heme pocket [chemical binding]; other site
857087002821	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087002822	PAS domain; Region: PAS_9; pfam13426
857087002823	putative active site [active]
857087002824	heme pocket [chemical binding]; other site
857087002825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002827	metal binding site [ion binding]; metal-binding site
857087002828	active site
857087002829	I-site; other site
857087002830	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087002831	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
857087002832	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
857087002833	FMN binding site [chemical binding]; other site
857087002834	active site
857087002835	catalytic residues [active]
857087002836	substrate binding site [chemical binding]; other site
857087002837	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
857087002838	GTP cyclohydrolase I; Provisional; Region: PLN03044
857087002839	homodecamer interface [polypeptide binding]; other site
857087002840	active site
857087002841	putative catalytic site residues [active]
857087002842	zinc binding site [ion binding]; other site
857087002843	GTP-CH-I/GFRP interaction surface; other site
857087002844	ferrochelatase; Reviewed; Region: hemH; PRK00035
857087002845	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
857087002846	C-terminal domain interface [polypeptide binding]; other site
857087002847	active site
857087002848	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
857087002849	active site
857087002850	N-terminal domain interface [polypeptide binding]; other site
857087002851	MutS domain III; Region: MutS_III; cl17822
857087002852	ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243
857087002853	Walker A/P-loop; other site
857087002854	ATP binding site [chemical binding]; other site
857087002855	Q-loop/lid; other site
857087002856	ABC transporter signature motif; other site
857087002857	Walker B; other site
857087002858	D-loop; other site
857087002859	H-loop/switch region; other site
857087002860	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
857087002861	ATP-grasp domain; Region: ATP-grasp; pfam02222
857087002862	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
857087002863	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087002864	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087002865	catalytic residue [active]
857087002866	HDOD domain; Region: HDOD; pfam08668
857087002867	Maf-like protein; Region: Maf; pfam02545
857087002868	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
857087002869	active site
857087002870	dimer interface [polypeptide binding]; other site
857087002871	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
857087002872	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
857087002873	putative phosphate acyltransferase; Provisional; Region: PRK05331
857087002874	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
857087002875	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
857087002876	dimer interface [polypeptide binding]; other site
857087002877	active site
857087002878	CoA binding pocket [chemical binding]; other site
857087002879	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
857087002880	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
857087002881	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
857087002882	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
857087002883	NAD(P) binding site [chemical binding]; other site
857087002884	homotetramer interface [polypeptide binding]; other site
857087002885	homodimer interface [polypeptide binding]; other site
857087002886	active site
857087002887	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002888	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002889	metal binding site [ion binding]; metal-binding site
857087002890	active site
857087002891	I-site; other site
857087002892	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
857087002893	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
857087002894	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
857087002895	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
857087002896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087002897	Major Facilitator Superfamily; Region: MFS_1; pfam07690
857087002898	putative substrate translocation pore; other site
857087002899	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
857087002900	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
857087002901	dimer interface [polypeptide binding]; other site
857087002902	ssDNA binding site [nucleotide binding]; other site
857087002903	tetramer (dimer of dimers) interface [polypeptide binding]; other site
857087002904	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087002905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087002906	S-adenosylmethionine binding site [chemical binding]; other site
857087002907	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
857087002908	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
857087002909	active site residue [active]
857087002910	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
857087002911	active site residue [active]
857087002912	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
857087002913	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
857087002914	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
857087002915	Inositol monophosphatase family; Region: Inositol_P; pfam00459
857087002916	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
857087002917	active site
857087002918	Ecdysteroid kinase; Region: EcKinase; cl17738
857087002919	Phosphotransferase enzyme family; Region: APH; pfam01636
857087002920	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
857087002921	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
857087002922	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
857087002923	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
857087002924	putative active site [active]
857087002925	catalytic triad [active]
857087002926	putative dimer interface [polypeptide binding]; other site
857087002927	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
857087002928	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087002929	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
857087002930	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
857087002931	putative catalytic residues [active]
857087002932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087002933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087002934	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
857087002935	dimerization interface [polypeptide binding]; other site
857087002936	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
857087002937	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
857087002938	Putative Ig domain; Region: He_PIG; pfam05345
857087002939	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087002940	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087002941	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087002942	RHS Repeat; Region: RHS_repeat; pfam05593
857087002943	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087002944	RHS Repeat; Region: RHS_repeat; pfam05593
857087002945	RHS Repeat; Region: RHS_repeat; pfam05593
857087002946	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087002947	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
857087002948	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
857087002949	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
857087002950	Walker A/P-loop; other site
857087002951	ATP binding site [chemical binding]; other site
857087002952	Q-loop/lid; other site
857087002953	ABC transporter signature motif; other site
857087002954	Walker B; other site
857087002955	D-loop; other site
857087002956	H-loop/switch region; other site
857087002957	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
857087002958	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
857087002959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087002960	dimer interface [polypeptide binding]; other site
857087002961	conserved gate region; other site
857087002962	putative PBP binding loops; other site
857087002963	ABC-ATPase subunit interface; other site
857087002964	PBP superfamily domain; Region: PBP_like_2; cl17296
857087002965	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
857087002966	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087002967	dimerization interface [polypeptide binding]; other site
857087002968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087002969	dimer interface [polypeptide binding]; other site
857087002970	phosphorylation site [posttranslational modification]
857087002971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087002972	ATP binding site [chemical binding]; other site
857087002973	Mg2+ binding site [ion binding]; other site
857087002974	G-X-G motif; other site
857087002975	Response regulator receiver domain; Region: Response_reg; pfam00072
857087002976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002977	active site
857087002978	phosphorylation site [posttranslational modification]
857087002979	intermolecular recognition site; other site
857087002980	dimerization interface [polypeptide binding]; other site
857087002981	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087002982	putative binding surface; other site
857087002983	active site
857087002984	Response regulator receiver domain; Region: Response_reg; pfam00072
857087002985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087002986	active site
857087002987	phosphorylation site [posttranslational modification]
857087002988	intermolecular recognition site; other site
857087002989	dimerization interface [polypeptide binding]; other site
857087002990	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087002991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087002992	metal binding site [ion binding]; metal-binding site
857087002993	active site
857087002994	I-site; other site
857087002995	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087002996	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
857087002997	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087002998	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087002999	N-terminal plug; other site
857087003000	ligand-binding site [chemical binding]; other site
857087003001	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
857087003002	oxalacetate binding site [chemical binding]; other site
857087003003	citrylCoA binding site [chemical binding]; other site
857087003004	coenzyme A binding site [chemical binding]; other site
857087003005	catalytic triad [active]
857087003006	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
857087003007	oxalacetate binding site [chemical binding]; other site
857087003008	citrylCoA binding site [chemical binding]; other site
857087003009	coenzyme A binding site [chemical binding]; other site
857087003010	catalytic triad [active]
857087003011	short chain dehydrogenase; Provisional; Region: PRK06500
857087003012	classical (c) SDRs; Region: SDR_c; cd05233
857087003013	NAD(P) binding site [chemical binding]; other site
857087003014	active site
857087003015	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
857087003016	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
857087003017	PYR/PP interface [polypeptide binding]; other site
857087003018	dimer interface [polypeptide binding]; other site
857087003019	TPP binding site [chemical binding]; other site
857087003020	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
857087003021	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
857087003022	TPP-binding site [chemical binding]; other site
857087003023	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
857087003024	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087003025	active site
857087003026	ATP binding site [chemical binding]; other site
857087003027	substrate binding site [chemical binding]; other site
857087003028	activation loop (A-loop); other site
857087003029	AAA ATPase domain; Region: AAA_16; pfam13191
857087003030	Predicted ATPase [General function prediction only]; Region: COG3899
857087003031	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087003032	GAF domain; Region: GAF; pfam01590
857087003033	PAS domain S-box; Region: sensory_box; TIGR00229
857087003034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003035	putative active site [active]
857087003036	heme pocket [chemical binding]; other site
857087003037	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087003038	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003039	putative active site [active]
857087003040	heme pocket [chemical binding]; other site
857087003041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003042	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087003043	putative active site [active]
857087003044	heme pocket [chemical binding]; other site
857087003045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087003046	dimer interface [polypeptide binding]; other site
857087003047	phosphorylation site [posttranslational modification]
857087003048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003049	ATP binding site [chemical binding]; other site
857087003050	Mg2+ binding site [ion binding]; other site
857087003051	G-X-G motif; other site
857087003052	Response regulator receiver domain; Region: Response_reg; pfam00072
857087003053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003054	active site
857087003055	phosphorylation site [posttranslational modification]
857087003056	intermolecular recognition site; other site
857087003057	dimerization interface [polypeptide binding]; other site
857087003058	Putative zinc-finger; Region: zf-HC2; pfam13490
857087003059	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
857087003060	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087003061	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087003062	DNA binding residues [nucleotide binding]
857087003063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087003064	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087003065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003066	S-adenosylmethionine binding site [chemical binding]; other site
857087003067	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
857087003068	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
857087003069	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
857087003070	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
857087003071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087003072	Walker A/P-loop; other site
857087003073	ATP binding site [chemical binding]; other site
857087003074	Q-loop/lid; other site
857087003075	ABC transporter signature motif; other site
857087003076	Walker B; other site
857087003077	D-loop; other site
857087003078	H-loop/switch region; other site
857087003079	inner membrane transport permease; Provisional; Region: PRK15066
857087003080	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
857087003081	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
857087003082	active site
857087003083	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
857087003084	tetramer (dimer of dimers) interface [polypeptide binding]; other site
857087003085	active site
857087003086	dimer interface [polypeptide binding]; other site
857087003087	threonine dehydratase; Reviewed; Region: PRK09224
857087003088	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
857087003089	tetramer interface [polypeptide binding]; other site
857087003090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087003091	catalytic residue [active]
857087003092	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
857087003093	putative Ile/Val binding site [chemical binding]; other site
857087003094	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
857087003095	putative Ile/Val binding site [chemical binding]; other site
857087003096	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
857087003097	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087003098	substrate binding pocket [chemical binding]; other site
857087003099	membrane-bound complex binding site; other site
857087003100	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
857087003101	hydrophobic ligand binding site; other site
857087003102	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087003103	dimerization interface [polypeptide binding]; other site
857087003104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003105	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087003106	putative active site [active]
857087003107	heme pocket [chemical binding]; other site
857087003108	PAS domain; Region: PAS; smart00091
857087003109	PAS domain S-box; Region: sensory_box; TIGR00229
857087003110	PAS domain; Region: PAS; smart00091
857087003111	PAS domain S-box; Region: sensory_box; TIGR00229
857087003112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003113	putative active site [active]
857087003114	heme pocket [chemical binding]; other site
857087003115	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003116	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087003117	putative active site [active]
857087003118	heme pocket [chemical binding]; other site
857087003119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003120	putative active site [active]
857087003121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087003122	heme pocket [chemical binding]; other site
857087003123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087003124	dimer interface [polypeptide binding]; other site
857087003125	phosphorylation site [posttranslational modification]
857087003126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003127	ATP binding site [chemical binding]; other site
857087003128	Mg2+ binding site [ion binding]; other site
857087003129	G-X-G motif; other site
857087003130	Response regulator receiver domain; Region: Response_reg; pfam00072
857087003131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003132	active site
857087003133	phosphorylation site [posttranslational modification]
857087003134	intermolecular recognition site; other site
857087003135	dimerization interface [polypeptide binding]; other site
857087003136	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087003137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003138	active site
857087003139	phosphorylation site [posttranslational modification]
857087003140	intermolecular recognition site; other site
857087003141	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087003142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003143	active site
857087003144	phosphorylation site [posttranslational modification]
857087003145	intermolecular recognition site; other site
857087003146	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003147	PAS fold; Region: PAS_3; pfam08447
857087003148	putative active site [active]
857087003149	heme pocket [chemical binding]; other site
857087003150	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087003151	GAF domain; Region: GAF; pfam01590
857087003152	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003153	PAS domain; Region: PAS_9; pfam13426
857087003154	putative active site [active]
857087003155	heme pocket [chemical binding]; other site
857087003156	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087003157	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087003158	metal binding site [ion binding]; metal-binding site
857087003159	active site
857087003160	I-site; other site
857087003161	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087003162	Uncharacterized conserved protein [Function unknown]; Region: COG2947
857087003163	Response regulator receiver domain; Region: Response_reg; pfam00072
857087003164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003165	active site
857087003166	phosphorylation site [posttranslational modification]
857087003167	intermolecular recognition site; other site
857087003168	dimerization interface [polypeptide binding]; other site
857087003169	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
857087003170	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
857087003171	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
857087003172	Walker A motif; other site
857087003173	ATP binding site [chemical binding]; other site
857087003174	Walker B motif; other site
857087003175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087003176	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003177	ATP binding site [chemical binding]; other site
857087003178	Mg2+ binding site [ion binding]; other site
857087003179	G-X-G motif; other site
857087003180	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
857087003181	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087003182	G1 box; other site
857087003183	GTP/Mg2+ binding site [chemical binding]; other site
857087003184	G2 box; other site
857087003185	Switch I region; other site
857087003186	G3 box; other site
857087003187	Switch II region; other site
857087003188	G4 box; other site
857087003189	G5 box; other site
857087003190	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087003191	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
857087003192	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
857087003193	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
857087003194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
857087003195	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
857087003196	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
857087003197	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
857087003198	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
857087003199	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
857087003200	Transposase; Region: HTH_Tnp_1; cl17663
857087003201	Transposase; Region: HTH_Tnp_1; cl17663
857087003202	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
857087003203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003204	Walker A motif; other site
857087003205	ATP binding site [chemical binding]; other site
857087003206	Walker B motif; other site
857087003207	arginine finger; other site
857087003208	Transposase; Region: HTH_Tnp_1; pfam01527
857087003209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087003210	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
857087003211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087003212	Walker A/P-loop; other site
857087003213	ATP binding site [chemical binding]; other site
857087003214	Q-loop/lid; other site
857087003215	ABC transporter signature motif; other site
857087003216	Walker B; other site
857087003217	D-loop; other site
857087003218	H-loop/switch region; other site
857087003219	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
857087003220	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
857087003221	NeuB family; Region: NeuB; pfam03102
857087003222	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
857087003223	NeuB binding interface [polypeptide binding]; other site
857087003224	putative substrate binding site [chemical binding]; other site
857087003225	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
857087003226	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
857087003227	active site
857087003228	homodimer interface [polypeptide binding]; other site
857087003229	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
857087003230	ligand binding site; other site
857087003231	tetramer interface; other site
857087003232	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
857087003233	Ligand Binding Site [chemical binding]; other site
857087003234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003235	S-adenosylmethionine binding site [chemical binding]; other site
857087003236	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087003237	Methyltransferase domain; Region: Methyltransf_11; pfam08241
857087003238	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087003239	active site
857087003240	dimer interface [polypeptide binding]; other site
857087003241	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
857087003242	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087003243	Ligand Binding Site [chemical binding]; other site
857087003244	Molecular Tunnel; other site
857087003245	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087003246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003247	S-adenosylmethionine binding site [chemical binding]; other site
857087003248	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
857087003249	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087003250	dimer interface [polypeptide binding]; other site
857087003251	active site
857087003252	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087003253	Ligand Binding Site [chemical binding]; other site
857087003254	Molecular Tunnel; other site
857087003255	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
857087003256	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
857087003257	substrate binding site [chemical binding]; other site
857087003258	glutamase interaction surface [polypeptide binding]; other site
857087003259	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
857087003260	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
857087003261	putative active site [active]
857087003262	oxyanion strand; other site
857087003263	catalytic triad [active]
857087003264	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
857087003265	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
857087003266	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
857087003267	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
857087003268	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087003269	FeS/SAM binding site; other site
857087003270	hypothetical protein; Provisional; Region: PRK05849
857087003271	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
857087003272	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
857087003273	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
857087003274	ligand-binding site [chemical binding]; other site
857087003275	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
857087003276	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
857087003277	catalytic triad [active]
857087003278	hypothetical protein; Provisional; Region: PRK08317
857087003279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003280	S-adenosylmethionine binding site [chemical binding]; other site
857087003281	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
857087003282	conserved cys residue [active]
857087003283	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
857087003284	active site
857087003285	metal-binding site
857087003286	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
857087003287	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
857087003288	putative ligand binding site [chemical binding]; other site
857087003289	putative catalytic site [active]
857087003290	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
857087003291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003292	S-adenosylmethionine binding site [chemical binding]; other site
857087003293	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
857087003294	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
857087003295	inhibitor-cofactor binding pocket; inhibition site
857087003296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087003297	catalytic residue [active]
857087003298	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
857087003299	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
857087003300	putative glycosyl transferase; Provisional; Region: PRK10063
857087003301	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
857087003302	metal-binding site
857087003303	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
857087003304	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
857087003305	trimer interface [polypeptide binding]; other site
857087003306	active site
857087003307	substrate binding site [chemical binding]; other site
857087003308	CoA binding site [chemical binding]; other site
857087003309	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003310	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087003311	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
857087003312	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
857087003313	Probable Catalytic site; other site
857087003314	metal-binding site
857087003315	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087003316	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
857087003317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087003318	NAD(P) binding site [chemical binding]; other site
857087003319	active site
857087003320	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
857087003321	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
857087003322	Mg++ binding site [ion binding]; other site
857087003323	putative catalytic motif [active]
857087003324	putative substrate binding site [chemical binding]; other site
857087003325	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
857087003326	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
857087003327	NAD(P) binding site [chemical binding]; other site
857087003328	homodimer interface [polypeptide binding]; other site
857087003329	substrate binding site [chemical binding]; other site
857087003330	active site
857087003331	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087003332	metal ion-dependent adhesion site (MIDAS); other site
857087003333	TIGR03503 family protein; Region: TIGR03503
857087003334	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
857087003335	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
857087003336	putative active site [active]
857087003337	putative metal binding site [ion binding]; other site
857087003338	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
857087003339	O-Antigen ligase; Region: Wzy_C; cl04850
857087003340	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087003341	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
857087003342	Methyltransferase domain; Region: Methyltransf_24; pfam13578
857087003343	Acyltransferase family; Region: Acyl_transf_3; pfam01757
857087003344	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087003345	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087003346	active site
857087003347	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087003348	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087003349	active site
857087003350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003351	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087003352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003353	TPR motif; other site
857087003354	binding surface
857087003355	acyl carrier protein; Provisional; Region: PRK07639
857087003356	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
857087003357	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
857087003358	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
857087003359	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
857087003360	Predicted membrane protein [Function unknown]; Region: COG2246
857087003361	GtrA-like protein; Region: GtrA; pfam04138
857087003362	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
857087003363	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
857087003364	Ligand binding site; other site
857087003365	Putative Catalytic site; other site
857087003366	DXD motif; other site
857087003367	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
857087003368	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087003369	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003370	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
857087003371	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
857087003372	dimer interface [polypeptide binding]; other site
857087003373	active site
857087003374	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087003375	catalytic residues [active]
857087003376	substrate binding site [chemical binding]; other site
857087003377	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
857087003378	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
857087003379	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
857087003380	acyl-activating enzyme (AAE) consensus motif; other site
857087003381	acyl-activating enzyme (AAE) consensus motif; other site
857087003382	putative AMP binding site [chemical binding]; other site
857087003383	putative active site [active]
857087003384	putative CoA binding site [chemical binding]; other site
857087003385	exosortase A; Region: exosortase_1; TIGR03109
857087003386	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
857087003387	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
857087003388	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
857087003389	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
857087003390	Substrate binding site; other site
857087003391	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
857087003392	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
857087003393	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
857087003394	Cl binding site [ion binding]; other site
857087003395	oligomer interface [polypeptide binding]; other site
857087003396	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
857087003397	Transcriptional regulator; Region: Rrf2; pfam02082
857087003398	Transcriptional regulator; Region: Rrf2; cl17282
857087003399	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
857087003400	putative ABC transporter; Region: ycf24; CHL00085
857087003401	FeS assembly ATPase SufC; Region: sufC; TIGR01978
857087003402	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
857087003403	Walker A/P-loop; other site
857087003404	ATP binding site [chemical binding]; other site
857087003405	Q-loop/lid; other site
857087003406	ABC transporter signature motif; other site
857087003407	Walker B; other site
857087003408	D-loop; other site
857087003409	H-loop/switch region; other site
857087003410	FeS assembly protein SufD; Region: sufD; TIGR01981
857087003411	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
857087003412	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
857087003413	putative active site [active]
857087003414	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
857087003415	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
857087003416	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087003417	catalytic residue [active]
857087003418	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
857087003419	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
857087003420	trimerization site [polypeptide binding]; other site
857087003421	active site
857087003422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003423	S-adenosylmethionine binding site [chemical binding]; other site
857087003424	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
857087003425	[2Fe-2S] cluster binding site [ion binding]; other site
857087003426	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
857087003427	SPFH domain / Band 7 family; Region: Band_7; pfam01145
857087003428	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
857087003429	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
857087003430	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
857087003431	Flavoprotein; Region: Flavoprotein; pfam02441
857087003432	dihydropteroate synthase-related protein; Region: TIGR00284
857087003433	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
857087003434	substrate binding pocket [chemical binding]; other site
857087003435	dimer interface [polypeptide binding]; other site
857087003436	inhibitor binding site; inhibition site
857087003437	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
857087003438	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
857087003439	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
857087003440	generic binding surface II; other site
857087003441	generic binding surface I; other site
857087003442	Predicted transporter component [General function prediction only]; Region: COG2391
857087003443	Predicted transporter component [General function prediction only]; Region: COG2391
857087003444	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
857087003445	Sulphur transport; Region: Sulf_transp; pfam04143
857087003446	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
857087003447	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
857087003448	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
857087003449	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
857087003450	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087003451	catalytic loop [active]
857087003452	iron binding site [ion binding]; other site
857087003453	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
857087003454	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
857087003455	[4Fe-4S] binding site [ion binding]; other site
857087003456	molybdopterin cofactor binding site; other site
857087003457	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
857087003458	molybdopterin cofactor binding site; other site
857087003459	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
857087003460	putative dimer interface [polypeptide binding]; other site
857087003461	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
857087003462	SLBB domain; Region: SLBB; pfam10531
857087003463	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
857087003464	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
857087003465	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
857087003466	putative dimer interface [polypeptide binding]; other site
857087003467	[2Fe-2S] cluster binding site [ion binding]; other site
857087003468	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
857087003469	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
857087003470	BolA-like protein; Region: BolA; pfam01722
857087003471	YciI-like protein; Reviewed; Region: PRK11370
857087003472	intracellular septation protein A; Reviewed; Region: PRK00259
857087003473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
857087003474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087003475	Sporulation related domain; Region: SPOR; pfam05036
857087003476	putative transposase OrfB; Reviewed; Region: PHA02517
857087003477	Homeodomain-like domain; Region: HTH_32; pfam13565
857087003478	Integrase core domain; Region: rve; pfam00665
857087003479	Integrase core domain; Region: rve_3; pfam13683
857087003480	Transposase; Region: HTH_Tnp_1; cl17663
857087003481	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087003482	RHS Repeat; Region: RHS_repeat; pfam05593
857087003483	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087003484	RHS Repeat; Region: RHS_repeat; pfam05593
857087003485	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087003486	RHS Repeat; Region: RHS_repeat; pfam05593
857087003487	RHS Repeat; Region: RHS_repeat; pfam05593
857087003488	RHS Repeat; Region: RHS_repeat; pfam05593
857087003489	RHS Repeat; Region: RHS_repeat; cl11982
857087003490	RHS Repeat; Region: RHS_repeat; pfam05593
857087003491	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087003492	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
857087003493	ParB-like nuclease domain; Region: ParB; smart00470
857087003494	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087003495	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087003496	putative active site [active]
857087003497	putative NTP binding site [chemical binding]; other site
857087003498	putative nucleic acid binding site [nucleotide binding]; other site
857087003499	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087003500	Transposase IS200 like; Region: Y1_Tnp; pfam01797
857087003501	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
857087003502	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
857087003503	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
857087003504	putative NAD(P) binding site [chemical binding]; other site
857087003505	active site
857087003506	putative substrate binding site [chemical binding]; other site
857087003507	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
857087003508	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
857087003509	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
857087003510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087003511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087003512	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
857087003513	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
857087003514	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
857087003515	GIY-YIG motif/motif A; other site
857087003516	active site
857087003517	catalytic site [active]
857087003518	putative DNA binding site [nucleotide binding]; other site
857087003519	metal binding site [ion binding]; metal-binding site
857087003520	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
857087003521	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
857087003522	Fe-S cluster binding site [ion binding]; other site
857087003523	DNA binding site [nucleotide binding]
857087003524	active site
857087003525	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087003526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003527	Walker A motif; other site
857087003528	ATP binding site [chemical binding]; other site
857087003529	Walker B motif; other site
857087003530	arginine finger; other site
857087003531	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
857087003532	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
857087003533	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
857087003534	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
857087003535	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
857087003536	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
857087003537	D-pathway; other site
857087003538	Putative ubiquinol binding site [chemical binding]; other site
857087003539	Low-spin heme (heme b) binding site [chemical binding]; other site
857087003540	Putative water exit pathway; other site
857087003541	Binuclear center (heme o3/CuB) [ion binding]; other site
857087003542	K-pathway; other site
857087003543	Putative proton exit pathway; other site
857087003544	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
857087003545	Subunit I/III interface [polypeptide binding]; other site
857087003546	Subunit III/IV interface [polypeptide binding]; other site
857087003547	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
857087003548	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
857087003549	Homeodomain-like domain; Region: HTH_32; pfam13565
857087003550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
857087003551	Integrase core domain; Region: rve; pfam00665
857087003552	Integrase core domain; Region: rve_3; pfam13683
857087003553	Transposase; Region: HTH_Tnp_1; cl17663
857087003554	Transposase; Region: HTH_Tnp_1; cl17663
857087003555	Transposase; Region: HTH_Tnp_1; cl17663
857087003556	putative transposase OrfB; Reviewed; Region: PHA02517
857087003557	Homeodomain-like domain; Region: HTH_32; pfam13565
857087003558	Integrase core domain; Region: rve; pfam00665
857087003559	Integrase core domain; Region: rve_3; pfam13683
857087003560	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
857087003561	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
857087003562	RNase E interface [polypeptide binding]; other site
857087003563	trimer interface [polypeptide binding]; other site
857087003564	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
857087003565	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
857087003566	RNase E interface [polypeptide binding]; other site
857087003567	trimer interface [polypeptide binding]; other site
857087003568	active site
857087003569	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
857087003570	putative nucleic acid binding region [nucleotide binding]; other site
857087003571	G-X-X-G motif; other site
857087003572	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
857087003573	RNA binding site [nucleotide binding]; other site
857087003574	domain interface; other site
857087003575	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
857087003576	16S/18S rRNA binding site [nucleotide binding]; other site
857087003577	S13e-L30e interaction site [polypeptide binding]; other site
857087003578	25S rRNA binding site [nucleotide binding]; other site
857087003579	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
857087003580	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
857087003581	RNA binding site [nucleotide binding]; other site
857087003582	active site
857087003583	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
857087003584	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
857087003585	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
857087003586	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
857087003587	translation initiation factor IF-2; Region: IF-2; TIGR00487
857087003588	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
857087003589	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
857087003590	G1 box; other site
857087003591	putative GEF interaction site [polypeptide binding]; other site
857087003592	GTP/Mg2+ binding site [chemical binding]; other site
857087003593	Switch I region; other site
857087003594	G2 box; other site
857087003595	G3 box; other site
857087003596	Switch II region; other site
857087003597	G4 box; other site
857087003598	G5 box; other site
857087003599	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
857087003600	Translation-initiation factor 2; Region: IF-2; pfam11987
857087003601	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
857087003602	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
857087003603	NusA N-terminal domain; Region: NusA_N; pfam08529
857087003604	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
857087003605	RNA binding site [nucleotide binding]; other site
857087003606	homodimer interface [polypeptide binding]; other site
857087003607	NusA-like KH domain; Region: KH_5; pfam13184
857087003608	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
857087003609	G-X-X-G motif; other site
857087003610	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
857087003611	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
857087003612	ribosome maturation protein RimP; Reviewed; Region: PRK00092
857087003613	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
857087003614	putative oligomer interface [polypeptide binding]; other site
857087003615	putative RNA binding site [nucleotide binding]; other site
857087003616	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
857087003617	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
857087003618	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
857087003619	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
857087003620	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087003621	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087003622	dimer interface [polypeptide binding]; other site
857087003623	putative CheW interface [polypeptide binding]; other site
857087003624	PBP superfamily domain; Region: PBP_like_2; cl17296
857087003625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087003626	PAS domain S-box; Region: sensory_box; TIGR00229
857087003627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003628	putative active site [active]
857087003629	heme pocket [chemical binding]; other site
857087003630	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087003631	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087003632	metal binding site [ion binding]; metal-binding site
857087003633	active site
857087003634	I-site; other site
857087003635	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
857087003636	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
857087003637	NAD(P) binding pocket [chemical binding]; other site
857087003638	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
857087003639	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087003640	ligand binding site [chemical binding]; other site
857087003641	flexible hinge region; other site
857087003642	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087003643	putative switch regulator; other site
857087003644	non-specific DNA interactions [nucleotide binding]; other site
857087003645	DNA binding site [nucleotide binding]
857087003646	sequence specific DNA binding site [nucleotide binding]; other site
857087003647	putative cAMP binding site [chemical binding]; other site
857087003648	fructose-1,6-bisphosphatase family protein; Region: PLN02628
857087003649	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
857087003650	AMP binding site [chemical binding]; other site
857087003651	metal binding site [ion binding]; metal-binding site
857087003652	active site
857087003653	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
857087003654	dimer interface [polypeptide binding]; other site
857087003655	FMN binding site [chemical binding]; other site
857087003656	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
857087003657	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
857087003658	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087003659	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
857087003660	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
857087003661	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
857087003662	active site
857087003663	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
857087003664	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
857087003665	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
857087003666	hypothetical protein; Provisional; Region: PRK14851
857087003667	FMN binding site [chemical binding]; other site
857087003668	dimer interface [polypeptide binding]; other site
857087003669	hypothetical protein; Validated; Region: PRK08223
857087003670	ThiF family; Region: ThiF; pfam00899
857087003671	ATP binding site [chemical binding]; other site
857087003672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
857087003673	Homeodomain-like domain; Region: HTH_32; pfam13565
857087003674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
857087003675	Integrase core domain; Region: rve; pfam00665
857087003676	Integrase core domain; Region: rve_3; pfam13683
857087003677	Transposase; Region: HTH_Tnp_1; cl17663
857087003678	Transposase; Region: HTH_Tnp_1; cl17663
857087003679	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
857087003680	Sel1-like repeats; Region: SEL1; smart00671
857087003681	Sel1-like repeats; Region: SEL1; smart00671
857087003682	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087003683	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087003684	catalytic residue [active]
857087003685	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
857087003686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003687	active site
857087003688	phosphorylation site [posttranslational modification]
857087003689	intermolecular recognition site; other site
857087003690	dimerization interface [polypeptide binding]; other site
857087003691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003692	Walker A motif; other site
857087003693	ATP binding site [chemical binding]; other site
857087003694	Walker B motif; other site
857087003695	arginine finger; other site
857087003696	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087003697	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
857087003698	GAF domain; Region: GAF_3; pfam13492
857087003699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003700	ATP binding site [chemical binding]; other site
857087003701	Mg2+ binding site [ion binding]; other site
857087003702	G-X-G motif; other site
857087003703	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087003704	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087003705	ligand binding site [chemical binding]; other site
857087003706	flexible hinge region; other site
857087003707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003708	binding surface
857087003709	TPR motif; other site
857087003710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003711	binding surface
857087003712	TPR motif; other site
857087003713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003714	binding surface
857087003715	TPR motif; other site
857087003716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003717	binding surface
857087003718	TPR motif; other site
857087003719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087003720	binding surface
857087003721	TPR motif; other site
857087003722	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
857087003723	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
857087003724	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
857087003725	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
857087003726	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087003727	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
857087003728	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
857087003729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003730	Walker A motif; other site
857087003731	ATP binding site [chemical binding]; other site
857087003732	Walker B motif; other site
857087003733	arginine finger; other site
857087003734	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
857087003735	active site
857087003736	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
857087003737	homodimer interface [polypeptide binding]; other site
857087003738	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
857087003739	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
857087003740	putative active site [active]
857087003741	putative catalytic site [active]
857087003742	FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019
857087003743	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
857087003744	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087003745	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
857087003746	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
857087003747	putative ADP-binding pocket [chemical binding]; other site
857087003748	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
857087003749	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087003750	active site
857087003751	dimer interface [polypeptide binding]; other site
857087003752	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087003753	Ligand Binding Site [chemical binding]; other site
857087003754	Molecular Tunnel; other site
857087003755	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
857087003756	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
857087003757	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
857087003758	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
857087003759	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003760	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087003761	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
857087003762	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003763	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
857087003764	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087003765	Ligand Binding Site [chemical binding]; other site
857087003766	Molecular Tunnel; other site
857087003767	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
857087003768	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087003769	G1 box; other site
857087003770	GTP/Mg2+ binding site [chemical binding]; other site
857087003771	G2 box; other site
857087003772	Switch I region; other site
857087003773	G3 box; other site
857087003774	Switch II region; other site
857087003775	G4 box; other site
857087003776	G5 box; other site
857087003777	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
857087003778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087003779	PAS domain; Region: PAS_9; pfam13426
857087003780	putative active site [active]
857087003781	heme pocket [chemical binding]; other site
857087003782	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
857087003783	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
857087003784	catalytic core [active]
857087003785	adenylate cyclase; Provisional; Region: cyaA; PRK09450
857087003786	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
857087003787	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
857087003788	PilZ domain; Region: PilZ; pfam07238
857087003789	Protein of unknown function (DUF466); Region: DUF466; cl01082
857087003790	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
857087003791	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
857087003792	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
857087003793	beta-RFAP synthase; Region: beta_RFAP_syn; TIGR00144
857087003794	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
857087003795	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
857087003796	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
857087003797	AAA domain; Region: AAA_17; pfam13207
857087003798	AAA domain; Region: AAA_18; pfam13238
857087003799	FOG: CBS domain [General function prediction only]; Region: COG0517
857087003800	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
857087003801	Nitrogen regulatory protein P-II; Region: P-II; smart00938
857087003802	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
857087003803	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
857087003804	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
857087003805	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
857087003806	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
857087003807	TrkA-N domain; Region: TrkA_N; pfam02254
857087003808	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
857087003809	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
857087003810	putative active site; other site
857087003811	catalytic triad [active]
857087003812	putative dimer interface [polypeptide binding]; other site
857087003813	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
857087003814	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
857087003815	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
857087003816	EamA-like transporter family; Region: EamA; pfam00892
857087003817	EamA-like transporter family; Region: EamA; pfam00892
857087003818	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
857087003819	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
857087003820	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087003821	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
857087003822	active site
857087003823	Zn binding site [ion binding]; other site
857087003824	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
857087003825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087003826	Coenzyme A binding pocket [chemical binding]; other site
857087003827	Peptidase_C39 like family; Region: DUF3335; pfam11814
857087003828	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
857087003829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003830	Walker A motif; other site
857087003831	ATP binding site [chemical binding]; other site
857087003832	Walker B motif; other site
857087003833	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
857087003834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087003835	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
857087003836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003837	ATP binding site [chemical binding]; other site
857087003838	Mg2+ binding site [ion binding]; other site
857087003839	G-X-G motif; other site
857087003840	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087003841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003842	active site
857087003843	phosphorylation site [posttranslational modification]
857087003844	intermolecular recognition site; other site
857087003845	dimerization interface [polypeptide binding]; other site
857087003846	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087003847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003848	active site
857087003849	phosphorylation site [posttranslational modification]
857087003850	intermolecular recognition site; other site
857087003851	dimerization interface [polypeptide binding]; other site
857087003852	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087003853	DNA binding residues [nucleotide binding]
857087003854	dimerization interface [polypeptide binding]; other site
857087003855	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
857087003856	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
857087003857	Walker A/P-loop; other site
857087003858	ATP binding site [chemical binding]; other site
857087003859	Q-loop/lid; other site
857087003860	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
857087003861	ABC transporter signature motif; other site
857087003862	Walker B; other site
857087003863	D-loop; other site
857087003864	H-loop/switch region; other site
857087003865	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
857087003866	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
857087003867	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
857087003868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087003869	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087003870	Walker A motif; other site
857087003871	ATP binding site [chemical binding]; other site
857087003872	Walker B motif; other site
857087003873	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087003874	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087003875	catalytic residue [active]
857087003876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087003877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087003878	active site
857087003879	phosphorylation site [posttranslational modification]
857087003880	intermolecular recognition site; other site
857087003881	dimerization interface [polypeptide binding]; other site
857087003882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087003883	DNA binding site [nucleotide binding]
857087003884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087003885	dimerization interface [polypeptide binding]; other site
857087003886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087003887	dimer interface [polypeptide binding]; other site
857087003888	phosphorylation site [posttranslational modification]
857087003889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003890	ATP binding site [chemical binding]; other site
857087003891	Mg2+ binding site [ion binding]; other site
857087003892	G-X-G motif; other site
857087003893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087003894	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087003895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087003896	ATP binding site [chemical binding]; other site
857087003897	Mg2+ binding site [ion binding]; other site
857087003898	G-X-G motif; other site
857087003899	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
857087003900	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
857087003901	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
857087003902	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
857087003903	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
857087003904	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
857087003905	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
857087003906	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
857087003907	Bacterial sugar transferase; Region: Bac_transf; pfam02397
857087003908	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
857087003909	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
857087003910	SLBB domain; Region: SLBB; pfam10531
857087003911	Chain length determinant protein; Region: Wzz; cl15801
857087003912	tyrosine kinase; Provisional; Region: PRK11519
857087003913	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
857087003914	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087003915	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087003916	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087003917	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087003918	Methyltransferase domain; Region: Methyltransf_11; pfam08241
857087003919	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
857087003920	putative metal binding site; other site
857087003921	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087003922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
857087003923	active site
857087003924	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087003925	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087003926	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
857087003927	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
857087003928	active site
857087003929	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087003930	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
857087003931	putative metal binding site [ion binding]; other site
857087003932	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
857087003933	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
857087003934	BON domain; Region: BON; pfam04972
857087003935	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087003936	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
857087003937	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
857087003938	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
857087003939	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
857087003940	AMMECR1; Region: AMMECR1; pfam01871
857087003941	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
857087003942	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
857087003943	ATP binding site [chemical binding]; other site
857087003944	Mg++ binding site [ion binding]; other site
857087003945	motif III; other site
857087003946	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087003947	nucleotide binding region [chemical binding]; other site
857087003948	ATP-binding site [chemical binding]; other site
857087003949	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
857087003950	putative RNA binding site [nucleotide binding]; other site
857087003951	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087003952	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
857087003953	DNA binding residues [nucleotide binding]
857087003954	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
857087003955	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
857087003956	heme binding site [chemical binding]; other site
857087003957	substrate binding site [chemical binding]; other site
857087003958	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
857087003959	putative heme binding pocket [chemical binding]; other site
857087003960	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
857087003961	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
857087003962	putative heme binding pocket [chemical binding]; other site
857087003963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087003964	Transposase; Region: HTH_Tnp_1; pfam01527
857087003965	putative transposase OrfB; Reviewed; Region: PHA02517
857087003966	HTH-like domain; Region: HTH_21; pfam13276
857087003967	Integrase core domain; Region: rve; pfam00665
857087003968	Integrase core domain; Region: rve_3; pfam13683
857087003969	HTH domain; Region: HTH_11; cl17392
857087003970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087003971	Transposase; Region: HTH_Tnp_1; pfam01527
857087003972	putative transposase OrfB; Reviewed; Region: PHA02517
857087003973	HTH-like domain; Region: HTH_21; pfam13276
857087003974	Integrase core domain; Region: rve; pfam00665
857087003975	Integrase core domain; Region: rve_3; cl15866
857087003976	Transposase; Region: HTH_Tnp_1; cl17663
857087003977	exosortase family protein XrtM; Region: exosort_XrtM; TIGR04300
857087003978	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087003979	RHS Repeat; Region: RHS_repeat; cl11982
857087003980	RHS Repeat; Region: RHS_repeat; pfam05593
857087003981	RHS Repeat; Region: RHS_repeat; pfam05593
857087003982	RHS Repeat; Region: RHS_repeat; pfam05593
857087003983	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087003984	RHS Repeat; Region: RHS_repeat; pfam05593
857087003985	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087003986	RHS Repeat; Region: RHS_repeat; pfam05593
857087003987	RHS Repeat; Region: RHS_repeat; pfam05593
857087003988	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087003989	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087003990	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087003991	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
857087003992	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
857087003993	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
857087003994	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
857087003995	active site residue [active]
857087003996	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
857087003997	electron transport complex RsxE subunit; Provisional; Region: PRK12405
857087003998	FMN-binding domain; Region: FMN_bind; cl01081
857087003999	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
857087004000	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
857087004001	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
857087004002	SLBB domain; Region: SLBB; pfam10531
857087004003	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
857087004004	ferredoxin; Provisional; Region: PRK08764
857087004005	Putative Fe-S cluster; Region: FeS; cl17515
857087004006	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
857087004007	electron transport complex protein RsxA; Provisional; Region: PRK05151
857087004008	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
857087004009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004010	putative active site [active]
857087004011	heme pocket [chemical binding]; other site
857087004012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004013	ATP binding site [chemical binding]; other site
857087004014	Mg2+ binding site [ion binding]; other site
857087004015	G-X-G motif; other site
857087004016	Nif-specific regulatory protein; Region: nifA; TIGR01817
857087004017	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
857087004018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087004019	Walker A motif; other site
857087004020	ATP binding site [chemical binding]; other site
857087004021	Walker B motif; other site
857087004022	arginine finger; other site
857087004023	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087004024	malate dehydrogenase; Provisional; Region: PRK13529
857087004025	Malic enzyme, N-terminal domain; Region: malic; pfam00390
857087004026	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
857087004027	NAD(P) binding site [chemical binding]; other site
857087004028	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
857087004029	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
857087004030	MgtE intracellular N domain; Region: MgtE_N; smart00924
857087004031	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
857087004032	Divalent cation transporter; Region: MgtE; cl00786
857087004033	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
857087004034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004035	active site
857087004036	phosphorylation site [posttranslational modification]
857087004037	intermolecular recognition site; other site
857087004038	dimerization interface [polypeptide binding]; other site
857087004039	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087004040	Zn2+ binding site [ion binding]; other site
857087004041	Mg2+ binding site [ion binding]; other site
857087004042	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087004043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087004044	dimer interface [polypeptide binding]; other site
857087004045	phosphorylation site [posttranslational modification]
857087004046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004047	ATP binding site [chemical binding]; other site
857087004048	Mg2+ binding site [ion binding]; other site
857087004049	G-X-G motif; other site
857087004050	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087004051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004052	active site
857087004053	phosphorylation site [posttranslational modification]
857087004054	intermolecular recognition site; other site
857087004055	dimerization interface [polypeptide binding]; other site
857087004056	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087004057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004058	active site
857087004059	phosphorylation site [posttranslational modification]
857087004060	intermolecular recognition site; other site
857087004061	dimerization interface [polypeptide binding]; other site
857087004062	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
857087004063	putative metal binding site [ion binding]; other site
857087004064	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
857087004065	nitrogenase iron protein; Region: nifH; TIGR01287
857087004066	Nucleotide-binding sites [chemical binding]; other site
857087004067	Walker A motif; other site
857087004068	Switch I region of nucleotide binding site; other site
857087004069	Fe4S4 binding sites [ion binding]; other site
857087004070	Switch II region of nucleotide binding site; other site
857087004071	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
857087004072	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
857087004073	MoFe protein alpha/beta subunit interactions; other site
857087004074	Alpha subunit P cluster binding residues; other site
857087004075	FeMoco binding residues [chemical binding]; other site
857087004076	MoFe protein alpha subunit/Fe protein contacts; other site
857087004077	MoFe protein dimer/ dimer interactions; other site
857087004078	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
857087004079	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
857087004080	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
857087004081	MoFe protein beta/alpha subunit interactions; other site
857087004082	Beta subunit P cluster binding residues; other site
857087004083	MoFe protein beta subunit/Fe protein contacts; other site
857087004084	MoFe protein dimer/ dimer interactions; other site
857087004085	NifT/FixU protein; Region: NifT; pfam06988
857087004086	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
857087004087	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
857087004088	HEAT repeats; Region: HEAT_2; pfam13646
857087004089	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
857087004090	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087004091	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
857087004092	Walker A/P-loop; other site
857087004093	ATP binding site [chemical binding]; other site
857087004094	Q-loop/lid; other site
857087004095	ABC transporter signature motif; other site
857087004096	Walker B; other site
857087004097	D-loop; other site
857087004098	H-loop/switch region; other site
857087004099	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087004100	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
857087004101	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
857087004102	purine monophosphate binding site [chemical binding]; other site
857087004103	dimer interface [polypeptide binding]; other site
857087004104	putative catalytic residues [active]
857087004105	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
857087004106	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
857087004107	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
857087004108	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
857087004109	FMN binding site [chemical binding]; other site
857087004110	active site
857087004111	catalytic residues [active]
857087004112	substrate binding site [chemical binding]; other site
857087004113	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
857087004114	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087004115	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087004116	ABC transporter; Region: ABC_tran_2; pfam12848
857087004117	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087004118	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
857087004119	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
857087004120	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
857087004121	Ion transport protein; Region: Ion_trans; pfam00520
857087004122	Ion channel; Region: Ion_trans_2; pfam07885
857087004123	Transcription elongation factor Spt4; Region: Spt4; cl12033
857087004124	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
857087004125	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
857087004126	DNA binding residues [nucleotide binding]
857087004127	dimer interface [polypeptide binding]; other site
857087004128	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
857087004129	catalytic residues [active]
857087004130	dimer interface [polypeptide binding]; other site
857087004131	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
857087004132	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087004133	catalytic residues [active]
857087004134	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
857087004135	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
857087004136	ligand binding site [chemical binding]; other site
857087004137	NAD binding site [chemical binding]; other site
857087004138	dimerization interface [polypeptide binding]; other site
857087004139	catalytic site [active]
857087004140	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
857087004141	putative L-serine binding site [chemical binding]; other site
857087004142	phosphoserine phosphatase SerB; Region: serB; TIGR00338
857087004143	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087004144	motif I; other site
857087004145	motif II; other site
857087004146	hypothetical protein; Validated; Region: PRK00110
857087004147	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
857087004148	active site
857087004149	putative DNA-binding cleft [nucleotide binding]; other site
857087004150	dimer interface [polypeptide binding]; other site
857087004151	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
857087004152	RuvA N terminal domain; Region: RuvA_N; pfam01330
857087004153	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
857087004154	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
857087004155	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
857087004156	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087004157	Walker A motif; other site
857087004158	ATP binding site [chemical binding]; other site
857087004159	Walker B motif; other site
857087004160	arginine finger; other site
857087004161	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
857087004162	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
857087004163	active site
857087004164	TolQ protein; Region: tolQ; TIGR02796
857087004165	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087004166	TolR protein; Region: tolR; TIGR02801
857087004167	TonB C terminal; Region: TonB_2; pfam13103
857087004168	TolA protein; Region: tolA_full; TIGR02794
857087004169	translocation protein TolB; Provisional; Region: tolB; PRK04922
857087004170	TolB amino-terminal domain; Region: TolB_N; pfam04052
857087004171	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
857087004172	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
857087004173	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
857087004174	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
857087004175	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087004176	ligand binding site [chemical binding]; other site
857087004177	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
857087004178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087004179	binding surface
857087004180	TPR motif; other site
857087004181	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
857087004182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087004183	FeS/SAM binding site; other site
857087004184	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
857087004185	Ligand Binding Site [chemical binding]; other site
857087004186	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
857087004187	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
857087004188	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
857087004189	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
857087004190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087004191	FeS/SAM binding site; other site
857087004192	TRAM domain; Region: TRAM; pfam01938
857087004193	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
857087004194	PhoH-like protein; Region: PhoH; pfam02562
857087004195	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
857087004196	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
857087004197	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
857087004198	Transporter associated domain; Region: CorC_HlyC; smart01091
857087004199	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
857087004200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087004201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087004202	dimerization interface [polypeptide binding]; other site
857087004203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087004204	dimer interface [polypeptide binding]; other site
857087004205	phosphorylation site [posttranslational modification]
857087004206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004207	ATP binding site [chemical binding]; other site
857087004208	Mg2+ binding site [ion binding]; other site
857087004209	G-X-G motif; other site
857087004210	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004212	active site
857087004213	phosphorylation site [posttranslational modification]
857087004214	intermolecular recognition site; other site
857087004215	dimerization interface [polypeptide binding]; other site
857087004216	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004218	active site
857087004219	phosphorylation site [posttranslational modification]
857087004220	intermolecular recognition site; other site
857087004221	dimerization interface [polypeptide binding]; other site
857087004222	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087004223	putative binding surface; other site
857087004224	active site
857087004225	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087004226	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
857087004227	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087004228	N-terminal plug; other site
857087004229	ligand-binding site [chemical binding]; other site
857087004230	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004232	active site
857087004233	phosphorylation site [posttranslational modification]
857087004234	intermolecular recognition site; other site
857087004235	dimerization interface [polypeptide binding]; other site
857087004236	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087004237	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087004238	metal binding site [ion binding]; metal-binding site
857087004239	active site
857087004240	I-site; other site
857087004241	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087004242	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
857087004243	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
857087004244	putative NAD(P) binding site [chemical binding]; other site
857087004245	putative substrate binding site [chemical binding]; other site
857087004246	catalytic Zn binding site [ion binding]; other site
857087004247	structural Zn binding site [ion binding]; other site
857087004248	dimer interface [polypeptide binding]; other site
857087004249	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
857087004250	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
857087004251	FMN binding site [chemical binding]; other site
857087004252	active site
857087004253	substrate binding site [chemical binding]; other site
857087004254	catalytic residue [active]
857087004255	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087004256	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
857087004257	glycogen synthase; Provisional; Region: glgA; PRK00654
857087004258	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
857087004259	ADP-binding pocket [chemical binding]; other site
857087004260	homodimer interface [polypeptide binding]; other site
857087004261	glycogen branching enzyme; Provisional; Region: PRK05402
857087004262	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
857087004263	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
857087004264	active site
857087004265	catalytic site [active]
857087004266	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
857087004267	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
857087004268	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
857087004269	ligand binding site; other site
857087004270	oligomer interface; other site
857087004271	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
857087004272	dimer interface [polypeptide binding]; other site
857087004273	N-terminal domain interface [polypeptide binding]; other site
857087004274	sulfate 1 binding site; other site
857087004275	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
857087004276	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
857087004277	putative active site [active]
857087004278	catalytic site [active]
857087004279	4-alpha-glucanotransferase; Provisional; Region: PRK14508
857087004280	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
857087004281	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087004282	membrane-bound complex binding site; other site
857087004283	hinge residues; other site
857087004284	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
857087004285	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
857087004286	Trp docking motif [polypeptide binding]; other site
857087004287	dimer interface [polypeptide binding]; other site
857087004288	active site
857087004289	small subunit binding site [polypeptide binding]; other site
857087004290	methionine sulfoxide reductase A; Provisional; Region: PRK00058
857087004291	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
857087004292	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
857087004293	dimerization interface [polypeptide binding]; other site
857087004294	domain crossover interface; other site
857087004295	redox-dependent activation switch; other site
857087004296	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
857087004297	putative FMN binding site [chemical binding]; other site
857087004298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087004299	HTH domain; Region: HTH_11; cl17392
857087004300	Integrase core domain; Region: rve; pfam00665
857087004301	putative transposase OrfB; Reviewed; Region: PHA02517
857087004302	Homeodomain-like domain; Region: HTH_32; pfam13565
857087004303	Integrase core domain; Region: rve; pfam00665
857087004304	Integrase core domain; Region: rve_3; pfam13683
857087004305	Transposase; Region: HTH_Tnp_1; cl17663
857087004306	integrase; Provisional; Region: int; PHA02601
857087004307	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
857087004308	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
857087004309	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
857087004310	FMN binding site [chemical binding]; other site
857087004311	active site
857087004312	substrate binding site [chemical binding]; other site
857087004313	catalytic residue [active]
857087004314	Pirin-related protein [General function prediction only]; Region: COG1741
857087004315	Pirin; Region: Pirin; pfam02678
857087004316	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
857087004317	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087004318	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087004319	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
857087004320	putative effector binding pocket; other site
857087004321	dimerization interface [polypeptide binding]; other site
857087004322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087004323	dimerization interface [polypeptide binding]; other site
857087004324	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087004325	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087004326	dimer interface [polypeptide binding]; other site
857087004327	putative CheW interface [polypeptide binding]; other site
857087004328	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
857087004329	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
857087004330	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
857087004331	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
857087004332	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
857087004333	homodimer interface [polypeptide binding]; other site
857087004334	substrate-cofactor binding pocket; other site
857087004335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087004336	catalytic residue [active]
857087004337	Protein of unknown function (DUF493); Region: DUF493; pfam04359
857087004338	lipoate-protein ligase B; Provisional; Region: PRK14342
857087004339	lipoyl synthase; Provisional; Region: PRK05481
857087004340	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
857087004341	FeS/SAM binding site; other site
857087004342	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
857087004343	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
857087004344	Mechanosensitive ion channel; Region: MS_channel; pfam00924
857087004345	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
857087004346	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087004347	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087004348	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
857087004349	Protein export membrane protein; Region: SecD_SecF; cl14618
857087004350	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
857087004351	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
857087004352	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087004353	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
857087004354	active site
857087004355	Zn binding site [ion binding]; other site
857087004356	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
857087004357	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
857087004358	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
857087004359	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
857087004360	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
857087004361	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
857087004362	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
857087004363	NADP binding site [chemical binding]; other site
857087004364	homopentamer interface [polypeptide binding]; other site
857087004365	substrate binding site [chemical binding]; other site
857087004366	active site
857087004367	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
857087004368	dimer interface [polypeptide binding]; other site
857087004369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087004370	Transposase; Region: HTH_Tnp_1; pfam01527
857087004371	putative transposase OrfB; Reviewed; Region: PHA02517
857087004372	HTH-like domain; Region: HTH_21; pfam13276
857087004373	Integrase core domain; Region: rve; pfam00665
857087004374	Integrase core domain; Region: rve_3; pfam13683
857087004375	integron integrase; Region: integrase_gron; TIGR02249
857087004376	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
857087004377	Int/Topo IB signature motif; other site
857087004378	Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690
857087004379	dimer interface [polypeptide binding]; other site
857087004380	putative transposase OrfB; Reviewed; Region: PHA02517
857087004381	Homeodomain-like domain; Region: HTH_32; pfam13565
857087004382	Integrase core domain; Region: rve; pfam00665
857087004383	Integrase core domain; Region: rve_3; pfam13683
857087004384	Transposase; Region: HTH_Tnp_1; cl17663
857087004385	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
857087004386	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
857087004387	trimer interface [polypeptide binding]; other site
857087004388	putative metal binding site [ion binding]; other site
857087004389	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
857087004390	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
857087004391	Short C-terminal domain; Region: SHOCT; pfam09851
857087004392	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
857087004393	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
857087004394	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
857087004395	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
857087004396	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
857087004397	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
857087004398	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
857087004399	nickel binding site [ion binding]; other site
857087004400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004401	PAS domain; Region: PAS_9; pfam13426
857087004402	putative active site [active]
857087004403	heme pocket [chemical binding]; other site
857087004404	PAS fold; Region: PAS_3; pfam08447
857087004405	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
857087004406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004407	PAS domain; Region: PAS_9; pfam13426
857087004408	putative active site [active]
857087004409	heme pocket [chemical binding]; other site
857087004410	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087004411	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087004412	metal binding site [ion binding]; metal-binding site
857087004413	active site
857087004414	I-site; other site
857087004415	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087004416	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
857087004417	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087004418	dimerization interface [polypeptide binding]; other site
857087004419	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087004420	dimer interface [polypeptide binding]; other site
857087004421	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
857087004422	putative CheW interface [polypeptide binding]; other site
857087004423	Chorismate lyase; Region: Chor_lyase; cl01230
857087004424	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
857087004425	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
857087004426	active site
857087004427	nucleophile elbow; other site
857087004428	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
857087004429	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
857087004430	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like4; cd07217
857087004431	active site
857087004432	nucleophile elbow; other site
857087004433	PQQ-like domain; Region: PQQ_2; pfam13360
857087004434	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
857087004435	structural tetrad; other site
857087004436	FOG: WD40 repeat [General function prediction only]; Region: COG2319
857087004437	TIR domain; Region: TIR_2; pfam13676
857087004438	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
857087004439	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
857087004440	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
857087004441	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
857087004442	hydrogenase 4 subunit F; Validated; Region: PRK06458
857087004443	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087004444	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
857087004445	NADH dehydrogenase; Region: NADHdh; cl00469
857087004446	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
857087004447	hydrogenase 4 subunit B; Validated; Region: PRK06521
857087004448	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087004449	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087004450	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087004451	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087004452	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087004453	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
857087004454	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
857087004455	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
857087004456	nickel responsive regulator; Provisional; Region: PRK02967
857087004457	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
857087004458	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
857087004459	CopC domain; Region: CopC; pfam04234
857087004460	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087004461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004462	active site
857087004463	phosphorylation site [posttranslational modification]
857087004464	intermolecular recognition site; other site
857087004465	dimerization interface [polypeptide binding]; other site
857087004466	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087004467	DNA binding site [nucleotide binding]
857087004468	sensor protein PhoQ; Provisional; Region: PRK10815
857087004469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004470	ATP binding site [chemical binding]; other site
857087004471	Mg2+ binding site [ion binding]; other site
857087004472	G-X-G motif; other site
857087004473	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
857087004474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087004475	N-terminal plug; other site
857087004476	ligand-binding site [chemical binding]; other site
857087004477	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
857087004478	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087004479	dimerization interface [polypeptide binding]; other site
857087004480	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087004481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087004482	dimer interface [polypeptide binding]; other site
857087004483	putative CheW interface [polypeptide binding]; other site
857087004484	Cytochrome c553 [Energy production and conversion]; Region: COG2863
857087004485	Cytochrome c; Region: Cytochrom_C; cl11414
857087004486	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
857087004487	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
857087004488	D-pathway; other site
857087004489	Low-spin heme binding site [chemical binding]; other site
857087004490	Putative water exit pathway; other site
857087004491	Binuclear center (active site) [active]
857087004492	K-pathway; other site
857087004493	Putative proton exit pathway; other site
857087004494	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
857087004495	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
857087004496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087004497	S-adenosylmethionine binding site [chemical binding]; other site
857087004498	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
857087004499	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
857087004500	putative catalytic cysteine [active]
857087004501	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
857087004502	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
857087004503	active site
857087004504	(T/H)XGH motif; other site
857087004505	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
857087004506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087004507	RES domain; Region: RES; cl02411
857087004508	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
857087004509	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
857087004510	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087004511	FeS/SAM binding site; other site
857087004512	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
857087004513	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
857087004514	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
857087004515	putative catalytic residues [active]
857087004516	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
857087004517	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
857087004518	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
857087004519	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
857087004520	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087004521	catalytic loop [active]
857087004522	iron binding site [ion binding]; other site
857087004523	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
857087004524	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087004525	catalytic loop [active]
857087004526	iron binding site [ion binding]; other site
857087004527	NifQ; Region: NifQ; pfam04891
857087004528	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087004529	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087004530	dimer interface [polypeptide binding]; other site
857087004531	putative CheW interface [polypeptide binding]; other site
857087004532	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
857087004533	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
857087004534	Flavodoxin; Region: Flavodoxin_1; pfam00258
857087004535	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
857087004536	FAD binding pocket [chemical binding]; other site
857087004537	FAD binding motif [chemical binding]; other site
857087004538	catalytic residues [active]
857087004539	NAD binding pocket [chemical binding]; other site
857087004540	phosphate binding motif [ion binding]; other site
857087004541	beta-alpha-beta structure motif; other site
857087004542	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
857087004543	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
857087004544	active site
857087004545	dimer interface [polypeptide binding]; other site
857087004546	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
857087004547	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
857087004548	active site
857087004549	FMN binding site [chemical binding]; other site
857087004550	substrate binding site [chemical binding]; other site
857087004551	3Fe-4S cluster binding site [ion binding]; other site
857087004552	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
857087004553	domain_subunit interface; other site
857087004554	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
857087004555	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
857087004556	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
857087004557	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
857087004558	metal binding triad; other site
857087004559	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
857087004560	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087004561	Zn2+ binding site [ion binding]; other site
857087004562	Mg2+ binding site [ion binding]; other site
857087004563	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
857087004564	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
857087004565	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
857087004566	active site
857087004567	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
857087004568	rRNA interaction site [nucleotide binding]; other site
857087004569	S8 interaction site; other site
857087004570	putative laminin-1 binding site; other site
857087004571	elongation factor Ts; Provisional; Region: tsf; PRK09377
857087004572	UBA/TS-N domain; Region: UBA; pfam00627
857087004573	Elongation factor TS; Region: EF_TS; pfam00889
857087004574	Elongation factor TS; Region: EF_TS; pfam00889
857087004575	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
857087004576	putative nucleotide binding site [chemical binding]; other site
857087004577	uridine monophosphate binding site [chemical binding]; other site
857087004578	homohexameric interface [polypeptide binding]; other site
857087004579	ribosome recycling factor; Reviewed; Region: frr; PRK00083
857087004580	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
857087004581	hinge region; other site
857087004582	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
857087004583	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
857087004584	catalytic residue [active]
857087004585	putative FPP diphosphate  binding site; other site
857087004586	putative FPP binding hydrophobic cleft; other site
857087004587	dimer interface [polypeptide binding]; other site
857087004588	putative IPP diphosphate binding site; other site
857087004589	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
857087004590	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
857087004591	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
857087004592	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
857087004593	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
857087004594	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
857087004595	zinc metallopeptidase RseP; Provisional; Region: PRK10779
857087004596	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
857087004597	active site
857087004598	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
857087004599	protein binding site [polypeptide binding]; other site
857087004600	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
857087004601	protein binding site [polypeptide binding]; other site
857087004602	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
857087004603	putative substrate binding region [chemical binding]; other site
857087004604	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
857087004605	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
857087004606	dimerization domain [polypeptide binding]; other site
857087004607	dimer interface [polypeptide binding]; other site
857087004608	catalytic residues [active]
857087004609	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
857087004610	MutS domain I; Region: MutS_I; pfam01624
857087004611	MutS domain II; Region: MutS_II; pfam05188
857087004612	MutS domain III; Region: MutS_III; pfam05192
857087004613	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
857087004614	Walker A/P-loop; other site
857087004615	ATP binding site [chemical binding]; other site
857087004616	Q-loop/lid; other site
857087004617	ABC transporter signature motif; other site
857087004618	Walker B; other site
857087004619	D-loop; other site
857087004620	H-loop/switch region; other site
857087004621	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
857087004622	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
857087004623	generic binding surface I; other site
857087004624	generic binding surface II; other site
857087004625	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
857087004626	putative active site [active]
857087004627	putative catalytic site [active]
857087004628	putative Mg binding site IVb [ion binding]; other site
857087004629	putative DNA binding site [nucleotide binding]; other site
857087004630	putative phosphate binding site [ion binding]; other site
857087004631	putative Mg binding site IVa [ion binding]; other site
857087004632	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
857087004633	dockerin binding interface; other site
857087004634	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
857087004635	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
857087004636	putative active site [active]
857087004637	putative metal binding site [ion binding]; other site
857087004638	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
857087004639	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
857087004640	PhoU domain; Region: PhoU; pfam01895
857087004641	PhoU domain; Region: PhoU; pfam01895
857087004642	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
857087004643	dimerization interface [polypeptide binding]; other site
857087004644	putative path to active site cavity [active]
857087004645	diiron center [ion binding]; other site
857087004646	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
857087004647	dimerization interface [polypeptide binding]; other site
857087004648	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
857087004649	Methane monooxygenase, hydrolase gamma chain; Region: MeMO_Hyd_G; pfam02964
857087004650	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087004651	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
857087004652	catalytic loop [active]
857087004653	iron binding site [ion binding]; other site
857087004654	Methane monooxygenase (MMO) reductase of methanotrophs catalyzes the NADH-dependent hydroxylation of methane to methanol. This multicomponent enzyme mediates electron transfer via a hydroxylase (MMOH), a coupling protein, and a reductase which is...; Region: MMO_FAD_NAD_binding; cd06210
857087004655	FAD binding pocket [chemical binding]; other site
857087004656	FAD binding motif [chemical binding]; other site
857087004657	phosphate binding motif [ion binding]; other site
857087004658	beta-alpha-beta structure motif; other site
857087004659	NAD binding pocket [chemical binding]; other site
857087004660	chaperonin GroL; Region: GroEL; TIGR02348
857087004661	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
857087004662	ring oligomerisation interface [polypeptide binding]; other site
857087004663	ATP/Mg binding site [chemical binding]; other site
857087004664	stacking interactions; other site
857087004665	hinge regions; other site
857087004666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087004667	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
857087004668	Walker A motif; other site
857087004669	ATP binding site [chemical binding]; other site
857087004670	Walker B motif; other site
857087004671	arginine finger; other site
857087004672	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087004673	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
857087004674	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087004675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087004676	S-adenosylmethionine binding site [chemical binding]; other site
857087004677	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
857087004678	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087004679	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087004680	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087004681	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087004682	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
857087004683	TAP-like protein; Region: Abhydrolase_4; pfam08386
857087004684	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
857087004685	Y-family of DNA polymerases; Region: PolY; cl12025
857087004686	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
857087004687	ssDNA binding site; other site
857087004688	generic binding surface II; other site
857087004689	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087004690	ATP binding site [chemical binding]; other site
857087004691	putative Mg++ binding site [ion binding]; other site
857087004692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087004693	nucleotide binding region [chemical binding]; other site
857087004694	ATP-binding site [chemical binding]; other site
857087004695	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
857087004696	homotrimer interaction site [polypeptide binding]; other site
857087004697	putative active site [active]
857087004698	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
857087004699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087004700	Zn2+ binding site [ion binding]; other site
857087004701	Mg2+ binding site [ion binding]; other site
857087004702	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
857087004703	synthetase active site [active]
857087004704	NTP binding site [chemical binding]; other site
857087004705	metal binding site [ion binding]; metal-binding site
857087004706	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
857087004707	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
857087004708	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
857087004709	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
857087004710	Peptidase family M48; Region: Peptidase_M48; pfam01435
857087004711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087004712	binding surface
857087004713	TPR motif; other site
857087004714	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
857087004715	DsrE/DsrF-like family; Region: DrsE; cl00672
857087004716	PilZ domain; Region: PilZ; cl01260
857087004717	Biotin operon repressor [Transcription]; Region: BirA; COG1654
857087004718	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
857087004719	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
857087004720	Type III pantothenate kinase; Region: Pan_kinase; cl17198
857087004721	PilZ domain; Region: PilZ; pfam07238
857087004722	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004724	active site
857087004725	phosphorylation site [posttranslational modification]
857087004726	intermolecular recognition site; other site
857087004727	dimerization interface [polypeptide binding]; other site
857087004728	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087004729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004730	putative active site [active]
857087004731	heme pocket [chemical binding]; other site
857087004732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087004733	dimer interface [polypeptide binding]; other site
857087004734	phosphorylation site [posttranslational modification]
857087004735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004736	ATP binding site [chemical binding]; other site
857087004737	Mg2+ binding site [ion binding]; other site
857087004738	G-X-G motif; other site
857087004739	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004741	active site
857087004742	phosphorylation site [posttranslational modification]
857087004743	intermolecular recognition site; other site
857087004744	dimerization interface [polypeptide binding]; other site
857087004745	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087004746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004747	active site
857087004748	phosphorylation site [posttranslational modification]
857087004749	intermolecular recognition site; other site
857087004750	dimerization interface [polypeptide binding]; other site
857087004751	Hpt domain; Region: Hpt; pfam01627
857087004752	putative binding surface; other site
857087004753	active site
857087004754	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087004755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004756	active site
857087004757	phosphorylation site [posttranslational modification]
857087004758	intermolecular recognition site; other site
857087004759	dimerization interface [polypeptide binding]; other site
857087004760	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087004761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004762	active site
857087004763	phosphorylation site [posttranslational modification]
857087004764	intermolecular recognition site; other site
857087004765	dimerization interface [polypeptide binding]; other site
857087004766	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087004767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087004768	dimer interface [polypeptide binding]; other site
857087004769	phosphorylation site [posttranslational modification]
857087004770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004771	ATP binding site [chemical binding]; other site
857087004772	Mg2+ binding site [ion binding]; other site
857087004773	G-X-G motif; other site
857087004774	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
857087004775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004776	putative active site [active]
857087004777	heme pocket [chemical binding]; other site
857087004778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004779	putative active site [active]
857087004780	heme pocket [chemical binding]; other site
857087004781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004782	ATP binding site [chemical binding]; other site
857087004783	Mg2+ binding site [ion binding]; other site
857087004784	G-X-G motif; other site
857087004785	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004787	active site
857087004788	phosphorylation site [posttranslational modification]
857087004789	intermolecular recognition site; other site
857087004790	dimerization interface [polypeptide binding]; other site
857087004791	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
857087004792	Response regulator receiver domain; Region: Response_reg; pfam00072
857087004793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004794	active site
857087004795	phosphorylation site [posttranslational modification]
857087004796	intermolecular recognition site; other site
857087004797	dimerization interface [polypeptide binding]; other site
857087004798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004799	PAS domain; Region: PAS_9; pfam13426
857087004800	putative active site [active]
857087004801	heme pocket [chemical binding]; other site
857087004802	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087004803	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087004804	metal binding site [ion binding]; metal-binding site
857087004805	active site
857087004806	I-site; other site
857087004807	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087004808	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
857087004809	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
857087004810	DNA binding residues [nucleotide binding]
857087004811	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
857087004812	B12 binding domain; Region: B12-binding_2; pfam02607
857087004813	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
857087004814	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087004815	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087004816	DNA binding residues [nucleotide binding]
857087004817	HflK protein; Region: hflK; TIGR01933
857087004818	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
857087004819	FtsH protease regulator HflC; Provisional; Region: PRK11029
857087004820	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
857087004821	FtsH Extracellular; Region: FtsH_ext; pfam06480
857087004822	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
857087004823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087004824	Walker A motif; other site
857087004825	ATP binding site [chemical binding]; other site
857087004826	Walker B motif; other site
857087004827	arginine finger; other site
857087004828	Peptidase family M41; Region: Peptidase_M41; pfam01434
857087004829	Sensors of blue-light using FAD; Region: BLUF; pfam04940
857087004830	Predicted membrane protein [Function unknown]; Region: COG3431
857087004831	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
857087004832	hydrophobic ligand binding site; other site
857087004833	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087004834	PAS domain; Region: PAS_9; pfam13426
857087004835	putative active site [active]
857087004836	heme pocket [chemical binding]; other site
857087004837	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
857087004838	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
857087004839	TMAO/DMSO reductase; Reviewed; Region: PRK05363
857087004840	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
857087004841	Moco binding site; other site
857087004842	metal coordination site [ion binding]; other site
857087004843	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
857087004844	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
857087004845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087004846	NAD(P) binding site [chemical binding]; other site
857087004847	active site
857087004848	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
857087004849	DNA photolyase; Region: DNA_photolyase; pfam00875
857087004850	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
857087004851	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
857087004852	Protein of unknown function (DUF523); Region: DUF523; pfam04463
857087004853	Uncharacterized conserved protein [Function unknown]; Region: COG3272
857087004854	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
857087004855	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
857087004856	cell division protein ZipA; Provisional; Region: PRK03427
857087004857	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
857087004858	active site
857087004859	Int/Topo IB signature motif; other site
857087004860	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
857087004861	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
857087004862	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
857087004863	SIR2-like domain; Region: SIR2_2; pfam13289
857087004864	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
857087004865	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087004866	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087004867	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
857087004868	HsdM N-terminal domain; Region: HsdM_N; pfam12161
857087004869	Methyltransferase domain; Region: Methyltransf_26; pfam13659
857087004870	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
857087004871	putative active site [active]
857087004872	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
857087004873	DEAD-like helicases superfamily; Region: DEXDc; smart00487
857087004874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087004875	ATP binding site [chemical binding]; other site
857087004876	putative Mg++ binding site [ion binding]; other site
857087004877	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
857087004878	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
857087004879	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
857087004880	DNA binding residues [nucleotide binding]
857087004881	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
857087004882	IHF dimer interface [polypeptide binding]; other site
857087004883	IHF - DNA interface [nucleotide binding]; other site
857087004884	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
857087004885	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
857087004886	putative tRNA-binding site [nucleotide binding]; other site
857087004887	B3/4 domain; Region: B3_4; pfam03483
857087004888	tRNA synthetase B5 domain; Region: B5; smart00874
857087004889	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
857087004890	dimer interface [polypeptide binding]; other site
857087004891	motif 1; other site
857087004892	motif 3; other site
857087004893	motif 2; other site
857087004894	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
857087004895	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
857087004896	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
857087004897	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
857087004898	dimer interface [polypeptide binding]; other site
857087004899	motif 1; other site
857087004900	active site
857087004901	motif 2; other site
857087004902	motif 3; other site
857087004903	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
857087004904	23S rRNA binding site [nucleotide binding]; other site
857087004905	L21 binding site [polypeptide binding]; other site
857087004906	L13 binding site [polypeptide binding]; other site
857087004907	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
857087004908	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
857087004909	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
857087004910	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
857087004911	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
857087004912	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
857087004913	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
857087004914	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
857087004915	active site
857087004916	dimer interface [polypeptide binding]; other site
857087004917	motif 1; other site
857087004918	motif 2; other site
857087004919	motif 3; other site
857087004920	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
857087004921	anticodon binding site; other site
857087004922	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
857087004923	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
857087004924	FAD binding domain; Region: FAD_binding_4; pfam01565
857087004925	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
857087004926	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
857087004927	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
857087004928	Cysteine-rich domain; Region: CCG; pfam02754
857087004929	Cysteine-rich domain; Region: CCG; pfam02754
857087004930	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
857087004931	FUN14 family; Region: FUN14; cl01015
857087004932	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
857087004933	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
857087004934	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
857087004935	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
857087004936	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
857087004937	active site
857087004938	putative substrate binding pocket [chemical binding]; other site
857087004939	Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059
857087004940	Transposase; Region: HTH_Tnp_1; cl17663
857087004941	putative transposase OrfB; Reviewed; Region: PHA02517
857087004942	HTH-like domain; Region: HTH_21; pfam13276
857087004943	Integrase core domain; Region: rve; pfam00665
857087004944	Integrase core domain; Region: rve_3; pfam13683
857087004945	Barstar (barnase inhibitor); Region: Barstar; pfam01337
857087004946	RNAase interaction site [polypeptide binding]; other site
857087004947	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087004948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087004949	active site
857087004950	phosphorylation site [posttranslational modification]
857087004951	intermolecular recognition site; other site
857087004952	dimerization interface [polypeptide binding]; other site
857087004953	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087004954	DNA binding residues [nucleotide binding]
857087004955	dimerization interface [polypeptide binding]; other site
857087004956	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
857087004957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087004958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087004959	ATP binding site [chemical binding]; other site
857087004960	Mg2+ binding site [ion binding]; other site
857087004961	G-X-G motif; other site
857087004962	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
857087004963	Part of AAA domain; Region: AAA_19; pfam13245
857087004964	Family description; Region: UvrD_C_2; pfam13538
857087004965	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
857087004966	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
857087004967	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
857087004968	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
857087004969	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
857087004970	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
857087004971	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
857087004972	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
857087004973	DsbD alpha interface [polypeptide binding]; other site
857087004974	catalytic residues [active]
857087004975	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
857087004976	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087004977	catalytic residues [active]
857087004978	Dehydroquinase class II; Region: DHquinase_II; pfam01220
857087004979	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
857087004980	trimer interface [polypeptide binding]; other site
857087004981	active site
857087004982	dimer interface [polypeptide binding]; other site
857087004983	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
857087004984	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
857087004985	carboxyltransferase (CT) interaction site; other site
857087004986	biotinylation site [posttranslational modification]; other site
857087004987	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
857087004988	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
857087004989	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
857087004990	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
857087004991	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
857087004992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087004993	S-adenosylmethionine binding site [chemical binding]; other site
857087004994	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
857087004995	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
857087004996	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
857087004997	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
857087004998	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
857087004999	putative RNA binding site [nucleotide binding]; other site
857087005000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087005001	S-adenosylmethionine binding site [chemical binding]; other site
857087005002	Autotransporter beta-domain; Region: Autotransporter; pfam03797
857087005003	Domain of unknown function DUF302; Region: DUF302; pfam03625
857087005004	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
857087005005	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
857087005006	GTP binding site; other site
857087005007	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
857087005008	Acylphosphatase; Region: Acylphosphatase; pfam00708
857087005009	HypF finger; Region: zf-HYPF; pfam07503
857087005010	HypF finger; Region: zf-HYPF; pfam07503
857087005011	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
857087005012	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
857087005013	dimerization interface [polypeptide binding]; other site
857087005014	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
857087005015	ATP binding site [chemical binding]; other site
857087005016	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
857087005017	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
857087005018	putative active site [active]
857087005019	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
857087005020	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
857087005021	HupF/HypC family; Region: HupF_HypC; pfam01455
857087005022	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087005023	G1 box; other site
857087005024	GTP/Mg2+ binding site [chemical binding]; other site
857087005025	G2 box; other site
857087005026	Switch I region; other site
857087005027	Switch II region; other site
857087005028	G4 box; other site
857087005029	G5 box; other site
857087005030	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
857087005031	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
857087005032	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
857087005033	potential frameshift: common BLAST hit: gi|288961722|ref|YP_003452032.1| rubredoxin
857087005034	Protein of unknown function (DUF3457); Region: DUF3457; pfam11939
857087005035	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
857087005036	Rubredoxin; Region: Rubredoxin; pfam00301
857087005037	iron binding site [ion binding]; other site
857087005038	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
857087005039	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
857087005040	Transposase IS200 like; Region: Y1_Tnp; cl00848
857087005041	CcdB protein; Region: CcdB; cl03380
857087005042	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
857087005043	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
857087005044	HupF/HypC family; Region: HupF_HypC; cl00394
857087005045	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
857087005046	nickel binding site [ion binding]; other site
857087005047	putative substrate-binding site; other site
857087005048	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
857087005049	hydrogenase 1 large subunit; Provisional; Region: PRK10170
857087005050	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
857087005051	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
857087005052	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
857087005053	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
857087005054	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
857087005055	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087005056	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
857087005057	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005058	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005059	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005060	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005061	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005062	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005063	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
857087005064	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
857087005065	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
857087005066	G1 box; other site
857087005067	GTP/Mg2+ binding site [chemical binding]; other site
857087005068	G2 box; other site
857087005069	Switch I region; other site
857087005070	G3 box; other site
857087005071	Switch II region; other site
857087005072	G4 box; other site
857087005073	G5 box; other site
857087005074	TIR domain; Region: TIR_2; pfam13676
857087005075	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087005076	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087005077	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
857087005078	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
857087005079	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
857087005080	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
857087005081	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
857087005082	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087005083	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087005084	N-terminal plug; other site
857087005085	ligand-binding site [chemical binding]; other site
857087005086	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
857087005087	metal binding site 2 [ion binding]; metal-binding site
857087005088	putative DNA binding helix; other site
857087005089	metal binding site 1 [ion binding]; metal-binding site
857087005090	dimer interface [polypeptide binding]; other site
857087005091	structural Zn2+ binding site [ion binding]; other site
857087005092	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
857087005093	heat shock protein HtpX; Provisional; Region: PRK05457
857087005094	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
857087005095	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
857087005096	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
857087005097	dimer interface [polypeptide binding]; other site
857087005098	ADP-ribose binding site [chemical binding]; other site
857087005099	active site
857087005100	nudix motif; other site
857087005101	metal binding site [ion binding]; metal-binding site
857087005102	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087005103	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087005104	DNA binding residues [nucleotide binding]
857087005105	dimerization interface [polypeptide binding]; other site
857087005106	putative transposase OrfB; Reviewed; Region: PHA02517
857087005107	Homeodomain-like domain; Region: HTH_32; pfam13565
857087005108	Integrase core domain; Region: rve; pfam00665
857087005109	Integrase core domain; Region: rve_3; pfam13683
857087005110	Transposase; Region: HTH_Tnp_1; cl17663
857087005111	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
857087005112	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
857087005113	Domain of unknown function (DUF389); Region: DUF389; pfam04087
857087005114	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
857087005115	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
857087005116	Peptidase M35 family; Region: M35_like; cl03449
857087005117	active site
857087005118	Zn binding site [ion binding]; other site
857087005119	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087005120	Zn2+ binding site [ion binding]; other site
857087005121	Mg2+ binding site [ion binding]; other site
857087005122	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
857087005123	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087005124	dimerization interface [polypeptide binding]; other site
857087005125	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087005126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087005127	dimer interface [polypeptide binding]; other site
857087005128	phosphorylation site [posttranslational modification]
857087005129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087005130	ATP binding site [chemical binding]; other site
857087005131	Mg2+ binding site [ion binding]; other site
857087005132	G-X-G motif; other site
857087005133	HI0933-like protein; Region: HI0933_like; pfam03486
857087005134	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
857087005135	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087005136	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087005137	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087005138	active site residue [active]
857087005139	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
857087005140	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
857087005141	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
857087005142	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
857087005143	LexA repressor; Validated; Region: PRK00215
857087005144	MarR family; Region: MarR_2; pfam12802
857087005145	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
857087005146	Catalytic site [active]
857087005147	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
857087005148	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
857087005149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087005150	ATP binding site [chemical binding]; other site
857087005151	putative Mg++ binding site [ion binding]; other site
857087005152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087005153	nucleotide binding region [chemical binding]; other site
857087005154	ATP-binding site [chemical binding]; other site
857087005155	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
857087005156	Flagellar regulator YcgR; Region: YcgR; pfam07317
857087005157	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
857087005158	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
857087005159	DsrH like protein; Region: DsrH; cl17347
857087005160	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
857087005161	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
857087005162	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
857087005163	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
857087005164	TRAM domain; Region: TRAM; cl01282
857087005165	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087005166	DNA-binding site [nucleotide binding]; DNA binding site
857087005167	RNA-binding motif; other site
857087005168	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087005169	DNA-binding site [nucleotide binding]; DNA binding site
857087005170	RNA-binding motif; other site
857087005171	pyruvate dehydrogenase; Provisional; Region: PRK09124
857087005172	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
857087005173	PYR/PP interface [polypeptide binding]; other site
857087005174	tetramer interface [polypeptide binding]; other site
857087005175	dimer interface [polypeptide binding]; other site
857087005176	TPP binding site [chemical binding]; other site
857087005177	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
857087005178	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
857087005179	TPP-binding site [chemical binding]; other site
857087005180	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
857087005181	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
857087005182	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
857087005183	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
857087005184	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
857087005185	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
857087005186	FAD binding pocket [chemical binding]; other site
857087005187	FAD binding motif [chemical binding]; other site
857087005188	phosphate binding motif [ion binding]; other site
857087005189	beta-alpha-beta structure motif; other site
857087005190	NAD binding pocket [chemical binding]; other site
857087005191	Iron coordination center [ion binding]; other site
857087005192	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
857087005193	Protein export membrane protein; Region: SecD_SecF; pfam02355
857087005194	Cation transport protein; Region: TrkH; cl17365
857087005195	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
857087005196	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
857087005197	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
857087005198	active site
857087005199	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
857087005200	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087005201	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
857087005202	lipoyl attachment site [posttranslational modification]; other site
857087005203	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
857087005204	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
857087005205	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
857087005206	substrate binding site [chemical binding]; other site
857087005207	ATP binding site [chemical binding]; other site
857087005208	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
857087005209	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
857087005210	homodimer interface [polypeptide binding]; other site
857087005211	metal binding site [ion binding]; metal-binding site
857087005212	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
857087005213	homodimer interface [polypeptide binding]; other site
857087005214	active site
857087005215	putative chemical substrate binding site [chemical binding]; other site
857087005216	metal binding site [ion binding]; metal-binding site
857087005217	MarC family integral membrane protein; Region: MarC; pfam01914
857087005218	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
857087005219	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
857087005220	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
857087005221	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
857087005222	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
857087005223	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
857087005224	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
857087005225	colanic acid exporter; Provisional; Region: PRK10459
857087005226	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
857087005227	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
857087005228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
857087005229	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
857087005230	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087005231	active site
857087005232	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
857087005233	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
857087005234	putative trimer interface [polypeptide binding]; other site
857087005235	putative CoA binding site [chemical binding]; other site
857087005236	O-Antigen ligase; Region: Wzy_C; pfam04932
857087005237	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
857087005238	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
857087005239	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
857087005240	Nucleotide binding site [chemical binding]; other site
857087005241	DTAP/Switch II; other site
857087005242	chain length determinant protein EpsF; Region: EpsF; TIGR03017
857087005243	Chain length determinant protein; Region: Wzz; pfam02706
857087005244	Chain length determinant protein; Region: Wzz; cl15801
857087005245	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
857087005246	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
857087005247	SLBB domain; Region: SLBB; pfam10531
857087005248	SLBB domain; Region: SLBB; pfam10531
857087005249	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
857087005250	Bacterial sugar transferase; Region: Bac_transf; pfam02397
857087005251	Predicted membrane protein [Function unknown]; Region: COG1238
857087005252	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087005253	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087005254	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087005255	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
857087005256	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
857087005257	catalytic triad [active]
857087005258	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087005259	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087005260	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087005261	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
857087005262	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087005263	Walker A/P-loop; other site
857087005264	ATP binding site [chemical binding]; other site
857087005265	Q-loop/lid; other site
857087005266	ABC transporter signature motif; other site
857087005267	Walker B; other site
857087005268	D-loop; other site
857087005269	H-loop/switch region; other site
857087005270	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087005271	FtsX-like permease family; Region: FtsX; pfam02687
857087005272	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087005273	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
857087005274	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087005275	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087005276	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
857087005277	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087005278	dimerization interface [polypeptide binding]; other site
857087005279	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087005280	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087005281	dimer interface [polypeptide binding]; other site
857087005282	putative CheW interface [polypeptide binding]; other site
857087005283	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
857087005284	Low molecular weight phosphatase family; Region: LMWPc; cd00115
857087005285	active site
857087005286	Dienelactone hydrolase family; Region: DLH; pfam01738
857087005287	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
857087005288	DNA gyrase subunit A; Validated; Region: PRK05560
857087005289	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
857087005290	CAP-like domain; other site
857087005291	active site
857087005292	primary dimer interface [polypeptide binding]; other site
857087005293	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005294	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005295	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005296	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005297	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005298	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
857087005299	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
857087005300	homodimer interface [polypeptide binding]; other site
857087005301	substrate-cofactor binding pocket; other site
857087005302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087005303	catalytic residue [active]
857087005304	Chorismate mutase type II; Region: CM_2; cl00693
857087005305	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
857087005306	Prephenate dehydratase; Region: PDT; pfam00800
857087005307	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
857087005308	putative L-Phe binding site [chemical binding]; other site
857087005309	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
857087005310	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087005311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087005312	homodimer interface [polypeptide binding]; other site
857087005313	catalytic residue [active]
857087005314	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
857087005315	prephenate dehydrogenase; Validated; Region: PRK08507
857087005316	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
857087005317	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
857087005318	hinge; other site
857087005319	active site
857087005320	cytidylate kinase; Provisional; Region: cmk; PRK00023
857087005321	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
857087005322	CMP-binding site; other site
857087005323	The sites determining sugar specificity; other site
857087005324	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
857087005325	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
857087005326	RNA binding site [nucleotide binding]; other site
857087005327	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
857087005328	RNA binding site [nucleotide binding]; other site
857087005329	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
857087005330	RNA binding site [nucleotide binding]; other site
857087005331	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
857087005332	RNA binding site [nucleotide binding]; other site
857087005333	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
857087005334	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
857087005335	RNA binding site [nucleotide binding]; other site
857087005336	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
857087005337	IHF - DNA interface [nucleotide binding]; other site
857087005338	IHF dimer interface [polypeptide binding]; other site
857087005339	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
857087005340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
857087005341	Putative esterase; Region: Esterase; pfam00756
857087005342	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087005343	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087005344	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087005345	multidrug efflux protein; Reviewed; Region: PRK09579
857087005346	Protein export membrane protein; Region: SecD_SecF; cl14618
857087005347	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
857087005348	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
857087005349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087005350	non-specific DNA binding site [nucleotide binding]; other site
857087005351	salt bridge; other site
857087005352	Predicted transcriptional regulator [Transcription]; Region: COG2932
857087005353	sequence-specific DNA binding site [nucleotide binding]; other site
857087005354	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
857087005355	Catalytic site [active]
857087005356	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
857087005357	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
857087005358	PhnA protein; Region: PhnA; pfam03831
857087005359	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
857087005360	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
857087005361	PAS fold; Region: PAS_4; pfam08448
857087005362	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005363	putative active site [active]
857087005364	heme pocket [chemical binding]; other site
857087005365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005366	PAS domain; Region: PAS_9; pfam13426
857087005367	putative active site [active]
857087005368	heme pocket [chemical binding]; other site
857087005369	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087005370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087005371	metal binding site [ion binding]; metal-binding site
857087005372	active site
857087005373	I-site; other site
857087005374	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087005375	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087005376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005377	active site
857087005378	phosphorylation site [posttranslational modification]
857087005379	intermolecular recognition site; other site
857087005380	dimerization interface [polypeptide binding]; other site
857087005381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087005382	DNA binding residues [nucleotide binding]
857087005383	dimerization interface [polypeptide binding]; other site
857087005384	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087005385	Histidine kinase; Region: HisKA_3; pfam07730
857087005386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087005387	ATP binding site [chemical binding]; other site
857087005388	Mg2+ binding site [ion binding]; other site
857087005389	G-X-G motif; other site
857087005390	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
857087005391	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
857087005392	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
857087005393	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
857087005394	E3 interaction surface; other site
857087005395	lipoyl attachment site [posttranslational modification]; other site
857087005396	e3 binding domain; Region: E3_binding; pfam02817
857087005397	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
857087005398	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
857087005399	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
857087005400	TPP-binding site [chemical binding]; other site
857087005401	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
857087005402	PYR/PP interface [polypeptide binding]; other site
857087005403	dimer interface [polypeptide binding]; other site
857087005404	TPP binding site [chemical binding]; other site
857087005405	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
857087005406	H-NS histone family; Region: Histone_HNS; pfam00816
857087005407	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
857087005408	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
857087005409	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
857087005410	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
857087005411	putative active site [active]
857087005412	Zn binding site [ion binding]; other site
857087005413	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
857087005414	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
857087005415	putative acyl-acceptor binding pocket; other site
857087005416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
857087005417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
857087005418	Family of unknown function (DUF490); Region: DUF490; pfam04357
857087005419	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
857087005420	Surface antigen; Region: Bac_surface_Ag; pfam01103
857087005421	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
857087005422	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087005423	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087005424	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087005425	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
857087005426	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
857087005427	Ligand Binding Site [chemical binding]; other site
857087005428	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
857087005429	Ligand Binding Site [chemical binding]; other site
857087005430	GAF domain; Region: GAF_3; pfam13492
857087005431	PAS domain; Region: PAS_9; pfam13426
857087005432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005433	putative active site [active]
857087005434	heme pocket [chemical binding]; other site
857087005435	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087005436	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087005437	metal binding site [ion binding]; metal-binding site
857087005438	active site
857087005439	I-site; other site
857087005440	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
857087005441	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
857087005442	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
857087005443	Mechanosensitive ion channel; Region: MS_channel; pfam00924
857087005444	PEP-CTERM motif; Region: VPEP; pfam07589
857087005445	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
857087005446	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
857087005447	ATP binding site [chemical binding]; other site
857087005448	Mg++ binding site [ion binding]; other site
857087005449	motif III; other site
857087005450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087005451	nucleotide binding region [chemical binding]; other site
857087005452	ATP-binding site [chemical binding]; other site
857087005453	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
857087005454	putative RNA binding site [nucleotide binding]; other site
857087005455	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
857087005456	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
857087005457	HDOD domain; Region: HDOD; pfam08668
857087005458	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
857087005459	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
857087005460	HDOD domain; Region: HDOD; pfam08668
857087005461	GAF domain; Region: GAF; cl17456
857087005462	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087005463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087005464	metal binding site [ion binding]; metal-binding site
857087005465	active site
857087005466	I-site; other site
857087005467	GTP-binding protein YchF; Reviewed; Region: PRK09601
857087005468	YchF GTPase; Region: YchF; cd01900
857087005469	G1 box; other site
857087005470	GTP/Mg2+ binding site [chemical binding]; other site
857087005471	Switch I region; other site
857087005472	G2 box; other site
857087005473	Switch II region; other site
857087005474	G3 box; other site
857087005475	G4 box; other site
857087005476	G5 box; other site
857087005477	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
857087005478	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
857087005479	Int/Topo IB signature motif; other site
857087005480	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
857087005481	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087005482	N-terminal plug; other site
857087005483	ligand-binding site [chemical binding]; other site
857087005484	Cytochrome P450; Region: p450; cl12078
857087005485	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
857087005486	Response regulator receiver domain; Region: Response_reg; pfam00072
857087005487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005488	active site
857087005489	phosphorylation site [posttranslational modification]
857087005490	intermolecular recognition site; other site
857087005491	dimerization interface [polypeptide binding]; other site
857087005492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087005493	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087005494	dimer interface [polypeptide binding]; other site
857087005495	phosphorylation site [posttranslational modification]
857087005496	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087005497	ATP binding site [chemical binding]; other site
857087005498	Mg2+ binding site [ion binding]; other site
857087005499	G-X-G motif; other site
857087005500	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
857087005501	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
857087005502	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087005503	P-loop; other site
857087005504	Magnesium ion binding site [ion binding]; other site
857087005505	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087005506	Magnesium ion binding site [ion binding]; other site
857087005507	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
857087005508	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
857087005509	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
857087005510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087005511	sequence-specific DNA binding site [nucleotide binding]; other site
857087005512	salt bridge; other site
857087005513	Restriction endonuclease; Region: Mrr_cat; pfam04471
857087005514	AAA ATPase domain; Region: AAA_16; pfam13191
857087005515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087005516	Integrase core domain; Region: rve; pfam00665
857087005517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087005518	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
857087005519	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087005520	Walker A motif; other site
857087005521	ATP binding site [chemical binding]; other site
857087005522	FOG: WD40 repeat [General function prediction only]; Region: COG2319
857087005523	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
857087005524	structural tetrad; other site
857087005525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087005526	Transposase; Region: HTH_Tnp_1; pfam01527
857087005527	putative transposase OrfB; Reviewed; Region: PHA02517
857087005528	HTH-like domain; Region: HTH_21; pfam13276
857087005529	Integrase core domain; Region: rve; pfam00665
857087005530	Integrase core domain; Region: rve_3; pfam13683
857087005531	Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577
857087005532	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
857087005533	substrate binding site [chemical binding]; other site
857087005534	Uncharacterized conserved protein [Function unknown]; Region: COG2135
857087005535	multiple promoter invertase; Provisional; Region: mpi; PRK13413
857087005536	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
857087005537	catalytic residues [active]
857087005538	catalytic nucleophile [active]
857087005539	Presynaptic Site I dimer interface [polypeptide binding]; other site
857087005540	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
857087005541	Synaptic Flat tetramer interface [polypeptide binding]; other site
857087005542	Synaptic Site I dimer interface [polypeptide binding]; other site
857087005543	DNA binding site [nucleotide binding]
857087005544	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
857087005545	DNA-binding interface [nucleotide binding]; DNA binding site
857087005546	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
857087005547	Predicted transcriptional regulator [Transcription]; Region: COG3905
857087005548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
857087005549	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
857087005550	Predicted transcriptional regulator [Transcription]; Region: COG3905
857087005551	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
857087005552	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
857087005553	Radical SAM superfamily; Region: Radical_SAM; pfam04055
857087005554	Transposase; Region: HTH_Tnp_1; cl17663
857087005555	putative transposase OrfB; Reviewed; Region: PHA02517
857087005556	HTH-like domain; Region: HTH_21; pfam13276
857087005557	Integrase core domain; Region: rve; pfam00665
857087005558	Integrase core domain; Region: rve_3; pfam13683
857087005559	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
857087005560	RES domain; Region: RES; cl02411
857087005561	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
857087005562	Predicted transcriptional regulator [Transcription]; Region: COG2944
857087005563	HsdM N-terminal domain; Region: HsdM_N; pfam12161
857087005564	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
857087005565	Methyltransferase domain; Region: Methyltransf_26; pfam13659
857087005566	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
857087005567	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
857087005568	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
857087005569	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
857087005570	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087005571	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087005572	Fic family protein [Function unknown]; Region: COG3177
857087005573	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
857087005574	Fic/DOC family; Region: Fic; pfam02661
857087005575	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
857087005576	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
857087005577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087005578	ATP binding site [chemical binding]; other site
857087005579	putative Mg++ binding site [ion binding]; other site
857087005580	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
857087005581	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
857087005582	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087005583	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087005584	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087005585	RHS Repeat; Region: RHS_repeat; pfam05593
857087005586	RHS Repeat; Region: RHS_repeat; pfam05593
857087005587	RHS Repeat; Region: RHS_repeat; pfam05593
857087005588	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087005589	RHS Repeat; Region: RHS_repeat; pfam05593
857087005590	RHS Repeat; Region: RHS_repeat; cl11982
857087005591	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087005592	Protein of unknown function (DUF4225); Region: DUF4225; pfam13988
857087005593	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
857087005594	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
857087005595	Transposase; Region: HTH_Tnp_1; pfam01527
857087005596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087005597	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
857087005598	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
857087005599	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
857087005600	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
857087005601	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
857087005602	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
857087005603	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
857087005604	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
857087005605	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
857087005606	MPN+ (JAMM) motif; other site
857087005607	Zinc-binding site [ion binding]; other site
857087005608	Domain of unknown function (DUF932); Region: DUF932; pfam06067
857087005609	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
857087005610	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
857087005611	active site
857087005612	DNA binding site [nucleotide binding]
857087005613	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
857087005614	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
857087005615	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
857087005616	Catalytic site [active]
857087005617	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
857087005618	active site
857087005619	catalytic site [active]
857087005620	substrate binding site [chemical binding]; other site
857087005621	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
857087005622	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
857087005623	GIY-YIG motif/motif A; other site
857087005624	active site
857087005625	catalytic site [active]
857087005626	putative DNA binding site [nucleotide binding]; other site
857087005627	metal binding site [ion binding]; metal-binding site
857087005628	Uncharacterized conserved protein [Function unknown]; Region: COG2135
857087005629	Sel1-like repeats; Region: SEL1; smart00671
857087005630	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087005631	Sel1-like repeats; Region: SEL1; smart00671
857087005632	Sel1-like repeats; Region: SEL1; smart00671
857087005633	Sel1-like repeats; Region: SEL1; smart00671
857087005634	Sel1-like repeats; Region: SEL1; smart00671
857087005635	Sel1-like repeats; Region: SEL1; smart00671
857087005636	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087005637	Sel1-like repeats; Region: SEL1; smart00671
857087005638	Sel1-like repeats; Region: SEL1; smart00671
857087005639	Sel1-like repeats; Region: SEL1; smart00671
857087005640	Sel1-like repeats; Region: SEL1; smart00671
857087005641	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
857087005642	Active site serine [active]
857087005643	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087005644	active site
857087005645	NTP binding site [chemical binding]; other site
857087005646	metal binding triad [ion binding]; metal-binding site
857087005647	antibiotic binding site [chemical binding]; other site
857087005648	ProQ/FINO family; Region: ProQ; pfam04352
857087005649	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
857087005650	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
857087005651	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087005652	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087005653	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
857087005654	catalytic residues [active]
857087005655	ParB-like nuclease domain; Region: ParBc; pfam02195
857087005656	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
857087005657	catalytic motif [active]
857087005658	Catalytic residue [active]
857087005659	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
857087005660	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
857087005661	active site
857087005662	DNA binding site [nucleotide binding]
857087005663	Int/Topo IB signature motif; other site
857087005664	integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765
857087005665	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
857087005666	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
857087005667	Transposase IS200 like; Region: Y1_Tnp; pfam01797
857087005668	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
857087005669	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
857087005670	Leucine rich repeat; Region: LRR_8; pfam13855
857087005671	Leucine-rich repeats; other site
857087005672	Leucine rich repeat; Region: LRR_8; pfam13855
857087005673	Leucine rich repeat; Region: LRR_8; pfam13855
857087005674	Leucine rich repeat; Region: LRR_8; pfam13855
857087005675	Leucine rich repeat; Region: LRR_8; pfam13855
857087005676	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087005677	HSP70 interaction site [polypeptide binding]; other site
857087005678	FRG domain; Region: FRG; pfam08867
857087005679	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
857087005680	Protein of unknown function (DUF3262); Region: DUF3262; cl13160
857087005681	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
857087005682	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
857087005683	Protein of unknown function (DUF2895); Region: DUF2895; pfam11444
857087005684	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
857087005685	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
857087005686	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
857087005687	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
857087005688	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
857087005689	Protein of unknown function (DUF1525); Region: DUF1525; cl06515
857087005690	putative transposase OrfB; Reviewed; Region: PHA02517
857087005691	HTH-like domain; Region: HTH_21; pfam13276
857087005692	Integrase core domain; Region: rve; pfam00665
857087005693	Integrase core domain; Region: rve_3; pfam13683
857087005694	Transposase; Region: HTH_Tnp_1; cl17663
857087005695	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
857087005696	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
857087005697	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
857087005698	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
857087005699	dimer interface [polypeptide binding]; other site
857087005700	metal binding sites [ion binding]; metal-binding site
857087005701	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
857087005702	Putative helicase; Region: TraI_2; pfam07514
857087005703	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
857087005704	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
857087005705	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
857087005706	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
857087005707	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087005708	FeS/SAM binding site; other site
857087005709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
857087005710	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
857087005711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
857087005712	Walker A motif; other site
857087005713	ATP binding site [chemical binding]; other site
857087005714	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087005715	putative DNA binding site [nucleotide binding]; other site
857087005716	putative Zn2+ binding site [ion binding]; other site
857087005717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087005718	binding surface
857087005719	TPR motif; other site
857087005720	TPR repeat; Region: TPR_11; pfam13414
857087005721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087005722	binding surface
857087005723	TPR motif; other site
857087005724	AAA ATPase domain; Region: AAA_16; pfam13191
857087005725	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
857087005726	N-acetyltransferase; Region: Acetyltransf_2; cl00949
857087005727	CAF1 family ribonuclease; Region: CAF1; cl17591
857087005728	Sensors of blue-light using FAD; Region: BLUF; pfam04940
857087005729	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
857087005730	putative ADP-ribose binding site [chemical binding]; other site
857087005731	putative active site [active]
857087005732	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087005733	Methyltransferase domain; Region: Methyltransf_12; pfam08242
857087005734	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
857087005735	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
857087005736	putative dimer interface [polypeptide binding]; other site
857087005737	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
857087005738	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
857087005739	nudix motif; other site
857087005740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087005741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087005742	WHG domain; Region: WHG; pfam13305
857087005743	lysophospholipid transporter LplT; Provisional; Region: PRK11195
857087005744	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
857087005745	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
857087005746	putative acyl-acceptor binding pocket; other site
857087005747	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
857087005748	acyl-activating enzyme (AAE) consensus motif; other site
857087005749	putative AMP binding site [chemical binding]; other site
857087005750	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087005751	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
857087005752	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
857087005753	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
857087005754	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
857087005755	Walker A motif; other site
857087005756	ATP binding site [chemical binding]; other site
857087005757	Walker B motif; other site
857087005758	Response regulator receiver domain; Region: Response_reg; pfam00072
857087005759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005760	active site
857087005761	phosphorylation site [posttranslational modification]
857087005762	intermolecular recognition site; other site
857087005763	dimerization interface [polypeptide binding]; other site
857087005764	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
857087005765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005766	active site
857087005767	phosphorylation site [posttranslational modification]
857087005768	intermolecular recognition site; other site
857087005769	dimerization interface [polypeptide binding]; other site
857087005770	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087005771	Zn2+ binding site [ion binding]; other site
857087005772	Mg2+ binding site [ion binding]; other site
857087005773	Hemerythrin; Region: Hemerythrin; cd12107
857087005774	Fe binding site [ion binding]; other site
857087005775	PAS domain S-box; Region: sensory_box; TIGR00229
857087005776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005777	putative active site [active]
857087005778	heme pocket [chemical binding]; other site
857087005779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087005780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087005781	dimer interface [polypeptide binding]; other site
857087005782	phosphorylation site [posttranslational modification]
857087005783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087005784	ATP binding site [chemical binding]; other site
857087005785	Mg2+ binding site [ion binding]; other site
857087005786	G-X-G motif; other site
857087005787	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
857087005788	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
857087005789	hexamer interface [polypeptide binding]; other site
857087005790	ligand binding site [chemical binding]; other site
857087005791	putative active site [active]
857087005792	NAD(P) binding site [chemical binding]; other site
857087005793	Response regulator receiver domain; Region: Response_reg; pfam00072
857087005794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005795	active site
857087005796	phosphorylation site [posttranslational modification]
857087005797	intermolecular recognition site; other site
857087005798	dimerization interface [polypeptide binding]; other site
857087005799	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
857087005800	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087005801	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
857087005802	substrate binding site [chemical binding]; other site
857087005803	dimerization interface [polypeptide binding]; other site
857087005804	Response regulator receiver domain; Region: Response_reg; pfam00072
857087005805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005806	active site
857087005807	phosphorylation site [posttranslational modification]
857087005808	intermolecular recognition site; other site
857087005809	dimerization interface [polypeptide binding]; other site
857087005810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005811	PAS domain; Region: PAS_9; pfam13426
857087005812	putative active site [active]
857087005813	heme pocket [chemical binding]; other site
857087005814	PAS domain; Region: PAS_9; pfam13426
857087005815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087005816	putative active site [active]
857087005817	heme pocket [chemical binding]; other site
857087005818	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087005819	Zn2+ binding site [ion binding]; other site
857087005820	Mg2+ binding site [ion binding]; other site
857087005821	Outer membrane efflux protein; Region: OEP; pfam02321
857087005822	Outer membrane efflux protein; Region: OEP; pfam02321
857087005823	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
857087005824	Cytochrome c553 [Energy production and conversion]; Region: COG2863
857087005825	Cytochrome c553 [Energy production and conversion]; Region: COG2863
857087005826	putative transporter; Validated; Region: PRK03818
857087005827	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
857087005828	TrkA-C domain; Region: TrkA_C; pfam02080
857087005829	TrkA-C domain; Region: TrkA_C; pfam02080
857087005830	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
857087005831	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
857087005832	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087005833	Coenzyme A binding pocket [chemical binding]; other site
857087005834	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
857087005835	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
857087005836	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
857087005837	dimer interface [polypeptide binding]; other site
857087005838	substrate binding site [chemical binding]; other site
857087005839	metal binding sites [ion binding]; metal-binding site
857087005840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087005841	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
857087005842	Walker A/P-loop; other site
857087005843	ATP binding site [chemical binding]; other site
857087005844	Q-loop/lid; other site
857087005845	ABC transporter signature motif; other site
857087005846	Walker B; other site
857087005847	D-loop; other site
857087005848	H-loop/switch region; other site
857087005849	TOBE domain; Region: TOBE; cl01440
857087005850	molybdenum-pterin binding domain; Region: Mop; TIGR00638
857087005851	molybdenum-pterin binding domain; Region: Mop; TIGR00638
857087005852	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
857087005853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087005854	Walker A/P-loop; other site
857087005855	ATP binding site [chemical binding]; other site
857087005856	Q-loop/lid; other site
857087005857	ABC transporter signature motif; other site
857087005858	Walker B; other site
857087005859	D-loop; other site
857087005860	H-loop/switch region; other site
857087005861	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
857087005862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087005863	dimer interface [polypeptide binding]; other site
857087005864	conserved gate region; other site
857087005865	putative PBP binding loops; other site
857087005866	ABC-ATPase subunit interface; other site
857087005867	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
857087005868	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
857087005869	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
857087005870	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
857087005871	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
857087005872	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
857087005873	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
857087005874	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
857087005875	catalytic triad [active]
857087005876	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
857087005877	SEC-C motif; Region: SEC-C; pfam02810
857087005878	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
857087005879	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
857087005880	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
857087005881	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
857087005882	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
857087005883	HDOD domain; Region: HDOD; pfam08668
857087005884	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087005885	dimerization interface [polypeptide binding]; other site
857087005886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087005887	dimer interface [polypeptide binding]; other site
857087005888	phosphorylation site [posttranslational modification]
857087005889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087005890	ATP binding site [chemical binding]; other site
857087005891	Mg2+ binding site [ion binding]; other site
857087005892	G-X-G motif; other site
857087005893	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087005894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005895	active site
857087005896	phosphorylation site [posttranslational modification]
857087005897	intermolecular recognition site; other site
857087005898	dimerization interface [polypeptide binding]; other site
857087005899	Response regulator receiver domain; Region: Response_reg; pfam00072
857087005900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005901	active site
857087005902	phosphorylation site [posttranslational modification]
857087005903	intermolecular recognition site; other site
857087005904	dimerization interface [polypeptide binding]; other site
857087005905	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087005906	putative binding surface; other site
857087005907	active site
857087005908	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087005909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087005910	active site
857087005911	phosphorylation site [posttranslational modification]
857087005912	intermolecular recognition site; other site
857087005913	dimerization interface [polypeptide binding]; other site
857087005914	PAS domain S-box; Region: sensory_box; TIGR00229
857087005915	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087005916	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087005917	metal binding site [ion binding]; metal-binding site
857087005918	active site
857087005919	I-site; other site
857087005920	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087005921	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087005922	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
857087005923	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087005924	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
857087005925	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
857087005926	DNA-binding site [nucleotide binding]; DNA binding site
857087005927	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087005928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087005929	homodimer interface [polypeptide binding]; other site
857087005930	catalytic residue [active]
857087005931	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
857087005932	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
857087005933	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
857087005934	homodimer interface [polypeptide binding]; other site
857087005935	substrate-cofactor binding pocket; other site
857087005936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087005937	catalytic residue [active]
857087005938	Cupin domain; Region: Cupin_2; cl17218
857087005939	Predicted transcriptional regulator [Transcription]; Region: COG2378
857087005940	HTH domain; Region: HTH_11; pfam08279
857087005941	WYL domain; Region: WYL; pfam13280
857087005942	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
857087005943	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
857087005944	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087005945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087005946	S-adenosylmethionine binding site [chemical binding]; other site
857087005947	2-isopropylmalate synthase; Validated; Region: PRK03739
857087005948	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
857087005949	active site
857087005950	catalytic residues [active]
857087005951	metal binding site [ion binding]; metal-binding site
857087005952	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
857087005953	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
857087005954	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087005955	putative DNA binding site [nucleotide binding]; other site
857087005956	putative Zn2+ binding site [ion binding]; other site
857087005957	AsnC family; Region: AsnC_trans_reg; pfam01037
857087005958	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
857087005959	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087005960	motif II; other site
857087005961	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
857087005962	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087005963	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087005964	O-methyltransferase; Region: Methyltransf_2; pfam00891
857087005965	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
857087005966	putative hydrophobic ligand binding site [chemical binding]; other site
857087005967	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
857087005968	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
857087005969	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
857087005970	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
857087005971	TIR domain; Region: TIR_2; pfam13676
857087005972	CHAT domain; Region: CHAT; pfam12770
857087005973	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087005974	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087005975	baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596
857087005976	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
857087005977	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087005978	ligand binding site [chemical binding]; other site
857087005979	flexible hinge region; other site
857087005980	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087005981	putative switch regulator; other site
857087005982	non-specific DNA interactions [nucleotide binding]; other site
857087005983	DNA binding site [nucleotide binding]
857087005984	sequence specific DNA binding site [nucleotide binding]; other site
857087005985	putative cAMP binding site [chemical binding]; other site
857087005986	FIST N domain; Region: FIST; pfam08495
857087005987	FIST C domain; Region: FIST_C; pfam10442
857087005988	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087005989	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087005990	metal binding site [ion binding]; metal-binding site
857087005991	active site
857087005992	I-site; other site
857087005993	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087005994	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
857087005995	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087005996	substrate binding pocket [chemical binding]; other site
857087005997	membrane-bound complex binding site; other site
857087005998	hinge residues; other site
857087005999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087006000	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087006001	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
857087006002	dimer interface [polypeptide binding]; other site
857087006003	Citrate synthase; Region: Citrate_synt; pfam00285
857087006004	active site
857087006005	citrylCoA binding site [chemical binding]; other site
857087006006	NADH binding [chemical binding]; other site
857087006007	cationic pore residues; other site
857087006008	oxalacetate/citrate binding site [chemical binding]; other site
857087006009	coenzyme A binding site [chemical binding]; other site
857087006010	catalytic triad [active]
857087006011	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
857087006012	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
857087006013	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
857087006014	Iron-sulfur protein interface; other site
857087006015	proximal quinone binding site [chemical binding]; other site
857087006016	SdhD (CybS) interface [polypeptide binding]; other site
857087006017	proximal heme binding site [chemical binding]; other site
857087006018	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
857087006019	Iron-sulfur protein interface; other site
857087006020	proximal heme binding site [chemical binding]; other site
857087006021	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
857087006022	L-aspartate oxidase; Provisional; Region: PRK06175
857087006023	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
857087006024	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
857087006025	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087006026	catalytic loop [active]
857087006027	iron binding site [ion binding]; other site
857087006028	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
857087006029	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
857087006030	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
857087006031	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
857087006032	PilX N-terminal; Region: PilX_N; pfam14341
857087006033	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
857087006034	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
857087006035	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
857087006036	Type II transport protein GspH; Region: GspH; pfam12019
857087006037	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087006038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006039	active site
857087006040	phosphorylation site [posttranslational modification]
857087006041	intermolecular recognition site; other site
857087006042	dimerization interface [polypeptide binding]; other site
857087006043	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
857087006044	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087006045	putative binding surface; other site
857087006046	active site
857087006047	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
857087006048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006049	ATP binding site [chemical binding]; other site
857087006050	Mg2+ binding site [ion binding]; other site
857087006051	G-X-G motif; other site
857087006052	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
857087006053	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
857087006054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006055	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087006056	putative active site [active]
857087006057	heme pocket [chemical binding]; other site
857087006058	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087006059	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006060	putative active site [active]
857087006061	heme pocket [chemical binding]; other site
857087006062	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006063	putative active site [active]
857087006064	heme pocket [chemical binding]; other site
857087006065	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087006066	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087006067	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087006068	dimer interface [polypeptide binding]; other site
857087006069	putative CheW interface [polypeptide binding]; other site
857087006070	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
857087006071	putative CheA interaction surface; other site
857087006072	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
857087006073	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087006074	P-loop; other site
857087006075	Magnesium ion binding site [ion binding]; other site
857087006076	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087006077	Magnesium ion binding site [ion binding]; other site
857087006078	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
857087006079	anti sigma factor interaction site; other site
857087006080	regulatory phosphorylation site [posttranslational modification]; other site
857087006081	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
857087006082	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
857087006083	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
857087006084	CheD chemotactic sensory transduction; Region: CheD; cl00810
857087006085	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
857087006086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006087	active site
857087006088	phosphorylation site [posttranslational modification]
857087006089	intermolecular recognition site; other site
857087006090	dimerization interface [polypeptide binding]; other site
857087006091	CheB methylesterase; Region: CheB_methylest; pfam01339
857087006092	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087006093	dimer interface [polypeptide binding]; other site
857087006094	putative CheW interface [polypeptide binding]; other site
857087006095	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
857087006096	anti sigma factor interaction site; other site
857087006097	regulatory phosphorylation site [posttranslational modification]; other site
857087006098	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
857087006099	Domain of unknown function DUF20; Region: UPF0118; pfam01594
857087006100	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
857087006101	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
857087006102	putative active site [active]
857087006103	PhoH-like protein; Region: PhoH; pfam02562
857087006104	TPR repeat; Region: TPR_11; pfam13414
857087006105	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
857087006106	DEAD/DEAH box helicase; Region: DEAD; pfam00270
857087006107	ATP binding site [chemical binding]; other site
857087006108	DEAD_2; Region: DEAD_2; pfam06733
857087006109	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
857087006110	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
857087006111	Glycoprotease family; Region: Peptidase_M22; pfam00814
857087006112	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
857087006113	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
857087006114	Peptidase family M50; Region: Peptidase_M50; pfam02163
857087006115	active site
857087006116	putative substrate binding region [chemical binding]; other site
857087006117	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
857087006118	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
857087006119	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
857087006120	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087006121	RNA binding surface [nucleotide binding]; other site
857087006122	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
857087006123	probable active site [active]
857087006124	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
857087006125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006126	active site
857087006127	phosphorylation site [posttranslational modification]
857087006128	intermolecular recognition site; other site
857087006129	dimerization interface [polypeptide binding]; other site
857087006130	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
857087006131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006132	active site
857087006133	phosphorylation site [posttranslational modification]
857087006134	intermolecular recognition site; other site
857087006135	dimerization interface [polypeptide binding]; other site
857087006136	Protein of unknown function (DUF447); Region: DUF447; pfam04289
857087006137	hypothetical protein; Provisional; Region: PRK02227
857087006138	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
857087006139	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
857087006140	glycine dehydrogenase; Provisional; Region: PRK05367
857087006141	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
857087006142	tetramer interface [polypeptide binding]; other site
857087006143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087006144	catalytic residue [active]
857087006145	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
857087006146	tetramer interface [polypeptide binding]; other site
857087006147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087006148	catalytic residue [active]
857087006149	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
857087006150	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
857087006151	Potassium binding sites [ion binding]; other site
857087006152	Cesium cation binding sites [ion binding]; other site
857087006153	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
857087006154	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
857087006155	putative GSH binding site (G-site) [chemical binding]; other site
857087006156	active site cysteine [active]
857087006157	putative C-terminal domain interface [polypeptide binding]; other site
857087006158	putative dimer interface [polypeptide binding]; other site
857087006159	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
857087006160	putative N-terminal domain interface [polypeptide binding]; other site
857087006161	putative dimer interface [polypeptide binding]; other site
857087006162	putative substrate binding pocket (H-site) [chemical binding]; other site
857087006163	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
857087006164	Ligand binding site; other site
857087006165	metal-binding site
857087006166	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
857087006167	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
857087006168	XdhC Rossmann domain; Region: XdhC_C; pfam13478
857087006169	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
857087006170	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087006171	catalytic loop [active]
857087006172	iron binding site [ion binding]; other site
857087006173	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
857087006174	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
857087006175	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
857087006176	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
857087006177	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
857087006178	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
857087006179	Dodecin; Region: Dodecin; pfam07311
857087006180	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
857087006181	thiamine phosphate binding site [chemical binding]; other site
857087006182	active site
857087006183	pyrophosphate binding site [ion binding]; other site
857087006184	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
857087006185	dimer interface [polypeptide binding]; other site
857087006186	substrate binding site [chemical binding]; other site
857087006187	ATP binding site [chemical binding]; other site
857087006188	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
857087006189	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
857087006190	nucleotide binding pocket [chemical binding]; other site
857087006191	K-X-D-G motif; other site
857087006192	catalytic site [active]
857087006193	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
857087006194	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
857087006195	Dimer interface [polypeptide binding]; other site
857087006196	BRCT sequence motif; other site
857087006197	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
857087006198	metal binding site 2 [ion binding]; metal-binding site
857087006199	putative DNA binding helix; other site
857087006200	metal binding site 1 [ion binding]; metal-binding site
857087006201	dimer interface [polypeptide binding]; other site
857087006202	structural Zn2+ binding site [ion binding]; other site
857087006203	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
857087006204	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006205	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006206	metal binding site [ion binding]; metal-binding site
857087006207	active site
857087006208	I-site; other site
857087006209	pyruvate phosphate dikinase; Provisional; Region: PRK09279
857087006210	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
857087006211	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
857087006212	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
857087006213	PQQ enzyme repeat; Region: PQQ; pfam01011
857087006214	Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007
857087006215	putative active site [active]
857087006216	putative Zn binding site [ion binding]; other site
857087006217	Transposase IS200 like; Region: Y1_Tnp; pfam01797
857087006218	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
857087006219	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
857087006220	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087006221	Transposase [DNA replication, recombination, and repair]; Region: COG5433
857087006222	hypothetical protein; Provisional; Region: PRK01254
857087006223	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
857087006224	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
857087006225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087006226	Right handed beta helix region; Region: Beta_helix; pfam13229
857087006227	FAD dependent oxidoreductase; Region: DAO; pfam01266
857087006228	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087006229	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
857087006230	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
857087006231	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
857087006232	nucleotide binding site [chemical binding]; other site
857087006233	putative NEF/HSP70 interaction site [polypeptide binding]; other site
857087006234	SBD interface [polypeptide binding]; other site
857087006235	putative outer membrane lipoprotein; Provisional; Region: PRK10510
857087006236	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087006237	ligand binding site [chemical binding]; other site
857087006238	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
857087006239	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
857087006240	MOSC domain; Region: MOSC; pfam03473
857087006241	PilZ domain; Region: PilZ; pfam07238
857087006242	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
857087006243	ligand binding site [chemical binding]; other site
857087006244	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
857087006245	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
857087006246	structural tetrad; other site
857087006247	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006248	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
857087006249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087006250	Walker A/P-loop; other site
857087006251	ATP binding site [chemical binding]; other site
857087006252	Q-loop/lid; other site
857087006253	ABC transporter signature motif; other site
857087006254	Walker B; other site
857087006255	D-loop; other site
857087006256	H-loop/switch region; other site
857087006257	ABC-2 type transporter; Region: ABC2_membrane; cl17235
857087006258	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
857087006259	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
857087006260	Peptidase family M50; Region: Peptidase_M50; pfam02163
857087006261	active site
857087006262	putative substrate binding region [chemical binding]; other site
857087006263	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
857087006264	Putative glucoamylase; Region: Glycoamylase; pfam10091
857087006265	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
857087006266	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
857087006267	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
857087006268	Protein of unknown function, DUF608; Region: DUF608; pfam04685
857087006269	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
857087006270	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
857087006271	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
857087006272	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087006273	ligand binding site [chemical binding]; other site
857087006274	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
857087006275	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006276	PAS domain; Region: PAS_9; pfam13426
857087006277	putative active site [active]
857087006278	heme pocket [chemical binding]; other site
857087006279	Homeodomain-like domain; Region: HTH_23; pfam13384
857087006280	Winged helix-turn helix; Region: HTH_29; pfam13551
857087006281	Homeodomain-like domain; Region: HTH_32; pfam13565
857087006282	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087006283	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006285	active site
857087006286	phosphorylation site [posttranslational modification]
857087006287	intermolecular recognition site; other site
857087006288	dimerization interface [polypeptide binding]; other site
857087006289	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087006290	Zn2+ binding site [ion binding]; other site
857087006291	Mg2+ binding site [ion binding]; other site
857087006292	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087006293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006294	active site
857087006295	phosphorylation site [posttranslational modification]
857087006296	intermolecular recognition site; other site
857087006297	dimerization interface [polypeptide binding]; other site
857087006298	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
857087006299	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006301	active site
857087006302	phosphorylation site [posttranslational modification]
857087006303	intermolecular recognition site; other site
857087006304	dimerization interface [polypeptide binding]; other site
857087006305	HDOD domain; Region: HDOD; pfam08668
857087006306	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
857087006307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006308	putative active site [active]
857087006309	heme pocket [chemical binding]; other site
857087006310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006311	ATP binding site [chemical binding]; other site
857087006312	Mg2+ binding site [ion binding]; other site
857087006313	G-X-G motif; other site
857087006314	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
857087006315	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
857087006316	ferric uptake regulator; Provisional; Region: fur; PRK09462
857087006317	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
857087006318	metal binding site 2 [ion binding]; metal-binding site
857087006319	putative DNA binding helix; other site
857087006320	metal binding site 1 [ion binding]; metal-binding site
857087006321	dimer interface [polypeptide binding]; other site
857087006322	structural Zn2+ binding site [ion binding]; other site
857087006323	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
857087006324	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087006325	FtsX-like permease family; Region: FtsX; pfam02687
857087006326	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
857087006327	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087006328	Walker A/P-loop; other site
857087006329	ATP binding site [chemical binding]; other site
857087006330	Q-loop/lid; other site
857087006331	ABC transporter signature motif; other site
857087006332	Walker B; other site
857087006333	D-loop; other site
857087006334	H-loop/switch region; other site
857087006335	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
857087006336	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087006337	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087006338	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
857087006339	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
857087006340	Competence protein; Region: Competence; pfam03772
857087006341	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
857087006342	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
857087006343	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
857087006344	V4R domain; Region: V4R; pfam02830
857087006345	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
857087006346	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087006347	ligand binding site [chemical binding]; other site
857087006348	Phosphotransferase enzyme family; Region: APH; pfam01636
857087006349	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
857087006350	active site
857087006351	ATP binding site [chemical binding]; other site
857087006352	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
857087006353	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
857087006354	active site
857087006355	HIGH motif; other site
857087006356	nucleotide binding site [chemical binding]; other site
857087006357	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
857087006358	KMSKS motif; other site
857087006359	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
857087006360	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
857087006361	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087006362	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
857087006363	Uncharacterized conserved protein [Function unknown]; Region: COG2135
857087006364	Protein of unknown function, DUF488; Region: DUF488; pfam04343
857087006365	HNH endonuclease; Region: HNH_5; pfam14279
857087006366	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
857087006367	active site
857087006368	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
857087006369	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087006370	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
857087006371	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
857087006372	trimer interface I [polypeptide binding]; other site
857087006373	putative substrate binding pocket [chemical binding]; other site
857087006374	trimer interface II [polypeptide binding]; other site
857087006375	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
857087006376	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087006377	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
857087006378	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
857087006379	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
857087006380	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
857087006381	active site
857087006382	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087006383	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
857087006384	nucleotide binding site [chemical binding]; other site
857087006385	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
857087006386	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
857087006387	chorismate binding enzyme; Region: Chorismate_bind; cl10555
857087006388	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
857087006389	nucleotide binding site [chemical binding]; other site
857087006390	substrate binding site [chemical binding]; other site
857087006391	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
857087006392	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087006393	G1 box; other site
857087006394	GTP/Mg2+ binding site [chemical binding]; other site
857087006395	G2 box; other site
857087006396	Switch I region; other site
857087006397	G3 box; other site
857087006398	Switch II region; other site
857087006399	G4 box; other site
857087006400	G5 box; other site
857087006401	Protein of unknown function, DUF258; Region: DUF258; pfam03193
857087006402	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087006403	G1 box; other site
857087006404	GTP/Mg2+ binding site [chemical binding]; other site
857087006405	G2 box; other site
857087006406	Switch I region; other site
857087006407	G3 box; other site
857087006408	Switch II region; other site
857087006409	G4 box; other site
857087006410	G5 box; other site
857087006411	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
857087006412	trehalose synthase; Region: treS_nterm; TIGR02456
857087006413	active site
857087006414	catalytic site [active]
857087006415	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
857087006416	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
857087006417	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
857087006418	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087006419	ligand binding site [chemical binding]; other site
857087006420	PilZ domain; Region: PilZ; pfam07238
857087006421	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
857087006422	catalytic residues [active]
857087006423	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
857087006424	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
857087006425	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
857087006426	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
857087006427	ligand binding site [chemical binding]; other site
857087006428	homodimer interface [polypeptide binding]; other site
857087006429	NAD(P) binding site [chemical binding]; other site
857087006430	trimer interface B [polypeptide binding]; other site
857087006431	trimer interface A [polypeptide binding]; other site
857087006432	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
857087006433	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006435	active site
857087006436	phosphorylation site [posttranslational modification]
857087006437	intermolecular recognition site; other site
857087006438	dimerization interface [polypeptide binding]; other site
857087006439	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006440	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006441	metal binding site [ion binding]; metal-binding site
857087006442	active site
857087006443	I-site; other site
857087006444	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG1665
857087006445	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
857087006446	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087006447	motif II; other site
857087006448	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
857087006449	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
857087006450	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
857087006451	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
857087006452	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
857087006453	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
857087006454	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087006455	active site
857087006456	beta-hexosaminidase; Provisional; Region: PRK05337
857087006457	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
857087006458	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
857087006459	putative transposase OrfB; Reviewed; Region: PHA02517
857087006460	Homeodomain-like domain; Region: HTH_32; pfam13565
857087006461	Integrase core domain; Region: rve; pfam00665
857087006462	Integrase core domain; Region: rve_3; pfam13683
857087006463	Transposase; Region: HTH_Tnp_1; cl17663
857087006464	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
857087006465	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
857087006466	Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007
857087006467	Part of AAA domain; Region: AAA_19; pfam13245
857087006468	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
857087006469	AAA domain; Region: AAA_30; pfam13604
857087006470	AAA domain; Region: AAA_12; pfam13087
857087006471	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
857087006472	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
857087006473	active site
857087006474	ATP binding site [chemical binding]; other site
857087006475	substrate binding site [chemical binding]; other site
857087006476	activation loop (A-loop); other site
857087006477	Protein phosphatase 2C; Region: PP2C_2; pfam13672
857087006478	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
857087006479	metal ion-dependent adhesion site (MIDAS); other site
857087006480	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
857087006481	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
857087006482	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
857087006483	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
857087006484	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
857087006485	Proteins of 100 residues with WXG; Region: WXG100; cl02005
857087006486	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
857087006487	metal ion-dependent adhesion site (MIDAS); other site
857087006488	WYL domain; Region: WYL; pfam13280
857087006489	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
857087006490	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
857087006491	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
857087006492	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
857087006493	exonuclease I; Provisional; Region: sbcB; PRK11779
857087006494	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
857087006495	active site
857087006496	catalytic site [active]
857087006497	substrate binding site [chemical binding]; other site
857087006498	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
857087006499	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
857087006500	putative hydrophobic ligand binding site [chemical binding]; other site
857087006501	protein interface [polypeptide binding]; other site
857087006502	gate; other site
857087006503	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006504	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
857087006505	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006506	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006507	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006508	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006509	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
857087006510	FeoC like transcriptional regulator; Region: FeoC; pfam09012
857087006511	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
857087006512	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
857087006513	G1 box; other site
857087006514	GTP/Mg2+ binding site [chemical binding]; other site
857087006515	Switch I region; other site
857087006516	G2 box; other site
857087006517	G3 box; other site
857087006518	Switch II region; other site
857087006519	G4 box; other site
857087006520	G5 box; other site
857087006521	Nucleoside recognition; Region: Gate; pfam07670
857087006522	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
857087006523	Nucleoside recognition; Region: Gate; pfam07670
857087006524	FeoA domain; Region: FeoA; pfam04023
857087006525	Zonular occludens toxin (Zot); Region: Zot; cl17485
857087006526	hypothetical protein; Region: PHA01159
857087006527	phage/plasmid replication protein, gene II/X family; Region: rep_II_X; TIGR01629
857087006528	Phage X family; Region: Phage_X; cl11585
857087006529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
857087006530	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
857087006531	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087006532	FeS/SAM binding site; other site
857087006533	HemN C-terminal domain; Region: HemN_C; pfam06969
857087006534	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
857087006535	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
857087006536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087006537	binding surface
857087006538	TPR motif; other site
857087006539	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
857087006540	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
857087006541	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087006542	catalytic residues [active]
857087006543	central insert; other site
857087006544	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
857087006545	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
857087006546	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
857087006547	heme exporter protein CcmC; Region: ccmC; TIGR01191
857087006548	CcmB protein; Region: CcmB; cl17444
857087006549	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
857087006550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087006551	Walker A/P-loop; other site
857087006552	ATP binding site [chemical binding]; other site
857087006553	Q-loop/lid; other site
857087006554	ABC transporter signature motif; other site
857087006555	Walker B; other site
857087006556	D-loop; other site
857087006557	H-loop/switch region; other site
857087006558	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
857087006559	Transposase; Region: HTH_Tnp_1; cl17663
857087006560	AAA domain; Region: AAA_21; pfam13304
857087006561	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
857087006562	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
857087006563	ATP-grasp domain; Region: ATP-grasp; pfam02222
857087006564	V-type ATP synthase subunit B; Provisional; Region: PRK02118
857087006565	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087006566	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
857087006567	Walker A motif homologous position; other site
857087006568	Walker B motif; other site
857087006569	ATP synthase subunit D; Region: ATP-synt_D; cl00613
857087006570	V-type ATP synthase subunit I; Validated; Region: PRK05771
857087006571	V-type ATP synthase subunit K; Provisional; Region: PRK09621
857087006572	ATP synthase subunit C; Region: ATP-synt_C; cl00466
857087006573	V-type ATP synthase subunit E; Provisional; Region: PRK01558
857087006574	V-type ATP synthase subunit E; Provisional; Region: PRK01005
857087006575	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
857087006576	V-type ATP synthase subunit A; Provisional; Region: PRK04192
857087006577	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
857087006578	Walker A motif/ATP binding site; other site
857087006579	Walker B motif; other site
857087006580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006581	PAS domain; Region: PAS_9; pfam13426
857087006582	putative active site [active]
857087006583	heme pocket [chemical binding]; other site
857087006584	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087006585	dimer interface [polypeptide binding]; other site
857087006586	putative CheW interface [polypeptide binding]; other site
857087006587	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
857087006588	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
857087006589	Chain length determinant protein; Region: Wzz; cl15801
857087006590	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
857087006591	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
857087006592	Uncharacterized protein conserved in archaea (DUF2096); Region: DUF2096; cl01637
857087006593	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006595	active site
857087006596	phosphorylation site [posttranslational modification]
857087006597	intermolecular recognition site; other site
857087006598	dimerization interface [polypeptide binding]; other site
857087006599	HDOD domain; Region: HDOD; pfam08668
857087006600	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087006601	Zn2+ binding site [ion binding]; other site
857087006602	Mg2+ binding site [ion binding]; other site
857087006603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087006604	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
857087006605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006606	PAS fold; Region: PAS_3; pfam08447
857087006607	putative active site [active]
857087006608	heme pocket [chemical binding]; other site
857087006609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087006610	dimer interface [polypeptide binding]; other site
857087006611	phosphorylation site [posttranslational modification]
857087006612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006613	ATP binding site [chemical binding]; other site
857087006614	Mg2+ binding site [ion binding]; other site
857087006615	G-X-G motif; other site
857087006616	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006618	active site
857087006619	phosphorylation site [posttranslational modification]
857087006620	intermolecular recognition site; other site
857087006621	dimerization interface [polypeptide binding]; other site
857087006622	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006623	PAS domain; Region: PAS_9; pfam13426
857087006624	putative active site [active]
857087006625	heme pocket [chemical binding]; other site
857087006626	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006627	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006628	metal binding site [ion binding]; metal-binding site
857087006629	active site
857087006630	I-site; other site
857087006631	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087006632	PAS domain S-box; Region: sensory_box; TIGR00229
857087006633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006634	putative active site [active]
857087006635	heme pocket [chemical binding]; other site
857087006636	GAF domain; Region: GAF_3; pfam13492
857087006637	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087006638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006640	metal binding site [ion binding]; metal-binding site
857087006641	active site
857087006642	I-site; other site
857087006643	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087006644	GAF domain; Region: GAF; pfam01590
857087006645	PAS domain S-box; Region: sensory_box; TIGR00229
857087006646	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006647	putative active site [active]
857087006648	heme pocket [chemical binding]; other site
857087006649	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
857087006650	Histidine kinase; Region: HisKA_2; pfam07568
857087006651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006652	ATP binding site [chemical binding]; other site
857087006653	Mg2+ binding site [ion binding]; other site
857087006654	G-X-G motif; other site
857087006655	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087006656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006657	active site
857087006658	phosphorylation site [posttranslational modification]
857087006659	intermolecular recognition site; other site
857087006660	dimerization interface [polypeptide binding]; other site
857087006661	PAS domain S-box; Region: sensory_box; TIGR00229
857087006662	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006663	putative active site [active]
857087006664	heme pocket [chemical binding]; other site
857087006665	PAS domain S-box; Region: sensory_box; TIGR00229
857087006666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006667	putative active site [active]
857087006668	heme pocket [chemical binding]; other site
857087006669	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006670	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006671	metal binding site [ion binding]; metal-binding site
857087006672	active site
857087006673	I-site; other site
857087006674	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087006675	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
857087006676	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
857087006677	dimerization interface 3.5A [polypeptide binding]; other site
857087006678	active site
857087006679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
857087006680	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
857087006681	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
857087006682	TRAM domain; Region: TRAM; pfam01938
857087006683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087006684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087006685	S-adenosylmethionine binding site [chemical binding]; other site
857087006686	cysteine synthase B; Region: cysM; TIGR01138
857087006687	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
857087006688	dimer interface [polypeptide binding]; other site
857087006689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087006690	catalytic residue [active]
857087006691	polyphosphate kinase; Provisional; Region: PRK05443
857087006692	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
857087006693	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
857087006694	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
857087006695	putative domain interface [polypeptide binding]; other site
857087006696	putative active site [active]
857087006697	catalytic site [active]
857087006698	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
857087006699	putative domain interface [polypeptide binding]; other site
857087006700	putative active site [active]
857087006701	catalytic site [active]
857087006702	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
857087006703	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
857087006704	active site
857087006705	catalytic site [active]
857087006706	substrate binding site [chemical binding]; other site
857087006707	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
857087006708	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
857087006709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087006710	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
857087006711	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087006712	DNA binding residues [nucleotide binding]
857087006713	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087006714	HSP70 interaction site [polypeptide binding]; other site
857087006715	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
857087006716	Walker A motif; other site
857087006717	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
857087006718	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
857087006719	dimer interface [polypeptide binding]; other site
857087006720	putative functional site; other site
857087006721	putative MPT binding site; other site
857087006722	Porin subfamily; Region: Porin_2; pfam02530
857087006723	PilZ domain; Region: PilZ; pfam07238
857087006724	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
857087006725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006727	metal binding site [ion binding]; metal-binding site
857087006728	active site
857087006729	I-site; other site
857087006730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087006731	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
857087006732	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
857087006733	active site residue [active]
857087006734	hypothetical protein; Provisional; Region: PRK08960
857087006735	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087006736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087006737	homodimer interface [polypeptide binding]; other site
857087006738	catalytic residue [active]
857087006739	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
857087006740	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
857087006741	active site
857087006742	nucleotide binding site [chemical binding]; other site
857087006743	HIGH motif; other site
857087006744	KMSKS motif; other site
857087006745	acetyl-CoA synthetase; Provisional; Region: PRK00174
857087006746	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
857087006747	active site
857087006748	CoA binding site [chemical binding]; other site
857087006749	acyl-activating enzyme (AAE) consensus motif; other site
857087006750	AMP binding site [chemical binding]; other site
857087006751	acetate binding site [chemical binding]; other site
857087006752	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
857087006753	EamA-like transporter family; Region: EamA; pfam00892
857087006754	EamA-like transporter family; Region: EamA; pfam00892
857087006755	KTSC domain; Region: KTSC; pfam13619
857087006756	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006758	active site
857087006759	phosphorylation site [posttranslational modification]
857087006760	intermolecular recognition site; other site
857087006761	dimerization interface [polypeptide binding]; other site
857087006762	PAS fold; Region: PAS_4; pfam08448
857087006763	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006764	putative active site [active]
857087006765	heme pocket [chemical binding]; other site
857087006766	GAF domain; Region: GAF_2; pfam13185
857087006767	GAF domain; Region: GAF; pfam01590
857087006768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006770	metal binding site [ion binding]; metal-binding site
857087006771	active site
857087006772	I-site; other site
857087006773	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087006774	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
857087006775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087006776	dimerization interface [polypeptide binding]; other site
857087006777	PAS domain S-box; Region: sensory_box; TIGR00229
857087006778	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006779	putative active site [active]
857087006780	heme pocket [chemical binding]; other site
857087006781	PAS domain S-box; Region: sensory_box; TIGR00229
857087006782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006783	putative active site [active]
857087006784	heme pocket [chemical binding]; other site
857087006785	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087006786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006787	putative active site [active]
857087006788	heme pocket [chemical binding]; other site
857087006789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087006790	dimer interface [polypeptide binding]; other site
857087006791	phosphorylation site [posttranslational modification]
857087006792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006793	ATP binding site [chemical binding]; other site
857087006794	Mg2+ binding site [ion binding]; other site
857087006795	G-X-G motif; other site
857087006796	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006798	active site
857087006799	phosphorylation site [posttranslational modification]
857087006800	intermolecular recognition site; other site
857087006801	dimerization interface [polypeptide binding]; other site
857087006802	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087006803	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087006804	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087006805	N-terminal plug; other site
857087006806	ligand-binding site [chemical binding]; other site
857087006807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006808	active site
857087006809	phosphorylation site [posttranslational modification]
857087006810	intermolecular recognition site; other site
857087006811	dimerization interface [polypeptide binding]; other site
857087006812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006813	PAS domain; Region: PAS_9; pfam13426
857087006814	putative active site [active]
857087006815	heme pocket [chemical binding]; other site
857087006816	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087006817	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087006818	metal binding site [ion binding]; metal-binding site
857087006819	active site
857087006820	I-site; other site
857087006821	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087006822	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087006823	dimer interface [polypeptide binding]; other site
857087006824	phosphorylation site [posttranslational modification]
857087006825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087006826	ATP binding site [chemical binding]; other site
857087006827	Mg2+ binding site [ion binding]; other site
857087006828	G-X-G motif; other site
857087006829	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006831	active site
857087006832	phosphorylation site [posttranslational modification]
857087006833	intermolecular recognition site; other site
857087006834	dimerization interface [polypeptide binding]; other site
857087006835	Response regulator receiver domain; Region: Response_reg; pfam00072
857087006836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087006837	active site
857087006838	phosphorylation site [posttranslational modification]
857087006839	intermolecular recognition site; other site
857087006840	dimerization interface [polypeptide binding]; other site
857087006841	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
857087006842	putative binding surface; other site
857087006843	active site
857087006844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087006845	dimerization interface [polypeptide binding]; other site
857087006846	PAS domain S-box; Region: sensory_box; TIGR00229
857087006847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006848	putative active site [active]
857087006849	heme pocket [chemical binding]; other site
857087006850	PAS domain S-box; Region: sensory_box; TIGR00229
857087006851	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006852	putative active site [active]
857087006853	heme pocket [chemical binding]; other site
857087006854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087006855	putative active site [active]
857087006856	heme pocket [chemical binding]; other site
857087006857	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
857087006858	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
857087006859	active site
857087006860	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
857087006861	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
857087006862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
857087006863	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
857087006864	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
857087006865	Peptidase family M48; Region: Peptidase_M48; pfam01435
857087006866	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
857087006867	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087006868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087006869	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
857087006870	TPR repeat; Region: TPR_11; pfam13414
857087006871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087006872	binding surface
857087006873	TPR motif; other site
857087006874	TPR repeat; Region: TPR_11; pfam13414
857087006875	TPR repeat; Region: TPR_11; pfam13414
857087006876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087006877	TPR motif; other site
857087006878	TPR repeat; Region: TPR_11; pfam13414
857087006879	binding surface
857087006880	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
857087006881	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
857087006882	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
857087006883	Walker A motif; other site
857087006884	ATP binding site [chemical binding]; other site
857087006885	Walker B motif; other site
857087006886	arginine finger; other site
857087006887	cell division protein MukB; Provisional; Region: mukB; PRK04863
857087006888	phage tail protein domain; Region: tail_TIGR02242
857087006889	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
857087006890	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
857087006891	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
857087006892	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
857087006893	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
857087006894	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
857087006895	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
857087006896	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
857087006897	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
857087006898	Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012
857087006899	PAS domain; Region: PAS_9; pfam13426
857087006900	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
857087006901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087006902	Walker A motif; other site
857087006903	ATP binding site [chemical binding]; other site
857087006904	Walker B motif; other site
857087006905	arginine finger; other site
857087006906	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087006907	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
857087006908	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
857087006909	active site
857087006910	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
857087006911	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087006912	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
857087006913	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087006914	Walker A/P-loop; other site
857087006915	ATP binding site [chemical binding]; other site
857087006916	Q-loop/lid; other site
857087006917	ABC transporter signature motif; other site
857087006918	Walker B; other site
857087006919	D-loop; other site
857087006920	H-loop/switch region; other site
857087006921	lytic murein transglycosylase; Provisional; Region: PRK11619
857087006922	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087006923	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087006924	catalytic residue [active]
857087006925	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
857087006926	active site 1 [active]
857087006927	dimer interface [polypeptide binding]; other site
857087006928	active site 2 [active]
857087006929	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
857087006930	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
857087006931	dimer interface [polypeptide binding]; other site
857087006932	active site
857087006933	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
857087006934	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
857087006935	Ligand Binding Site [chemical binding]; other site
857087006936	UDP-glucose 4-epimerase; Region: PLN02240
857087006937	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
857087006938	NAD binding site [chemical binding]; other site
857087006939	homodimer interface [polypeptide binding]; other site
857087006940	active site
857087006941	substrate binding site [chemical binding]; other site
857087006942	TfoX N-terminal domain; Region: TfoX_N; pfam04993
857087006943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
857087006944	5-oxoprolinase; Region: PLN02666
857087006945	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
857087006946	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
857087006947	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
857087006948	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
857087006949	Predicted transcriptional regulators [Transcription]; Region: COG1733
857087006950	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
857087006951	SCP-2 sterol transfer family; Region: SCP2; pfam02036
857087006952	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
857087006953	active site 1 [active]
857087006954	dimer interface [polypeptide binding]; other site
857087006955	hexamer interface [polypeptide binding]; other site
857087006956	active site 2 [active]
857087006957	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
857087006958	MG2 domain; Region: A2M_N; pfam01835
857087006959	Alpha-2-macroglobulin family; Region: A2M; pfam00207
857087006960	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
857087006961	surface patch; other site
857087006962	thioester region; other site
857087006963	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
857087006964	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
857087006965	Active site cavity [active]
857087006966	catalytic acid [active]
857087006967	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
857087006968	type II secretion system protein E; Region: type_II_gspE; TIGR02533
857087006969	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
857087006970	Walker A motif; other site
857087006971	ATP binding site [chemical binding]; other site
857087006972	Walker B motif; other site
857087006973	Protein of unknown function (DUF2167); Region: DUF2167; pfam09935
857087006974	putative transposase OrfB; Reviewed; Region: PHA02517
857087006975	Homeodomain-like domain; Region: HTH_32; pfam13565
857087006976	Integrase core domain; Region: rve; pfam00665
857087006977	Integrase core domain; Region: rve_3; pfam13683
857087006978	Transposase; Region: HTH_Tnp_1; cl17663
857087006979	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
857087006980	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087006981	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087006982	ligand binding site [chemical binding]; other site
857087006983	flexible hinge region; other site
857087006984	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087006985	non-specific DNA interactions [nucleotide binding]; other site
857087006986	DNA binding site [nucleotide binding]
857087006987	sequence specific DNA binding site [nucleotide binding]; other site
857087006988	putative cAMP binding site [chemical binding]; other site
857087006989	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
857087006990	Putative transposase; Region: Y2_Tnp; pfam04986
857087006991	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
857087006992	Fic family protein [Function unknown]; Region: COG3177
857087006993	Fic/DOC family; Region: Fic; pfam02661
857087006994	HEPN domain; Region: HEPN; cl00824
857087006995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087006996	Transposase; Region: HTH_Tnp_1; pfam01527
857087006997	putative transposase OrfB; Reviewed; Region: PHA02517
857087006998	HTH-like domain; Region: HTH_21; pfam13276
857087006999	Integrase core domain; Region: rve; pfam00665
857087007000	Integrase core domain; Region: rve_3; pfam13683
857087007001	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087007002	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087007003	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087007004	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087007005	Transposase; Region: HTH_Tnp_1; cl17663
857087007006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
857087007007	Transposase; Region: DEDD_Tnp_IS110; pfam01548
857087007008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
857087007009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087007010	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087007011	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087007012	putative active site [active]
857087007013	putative NTP binding site [chemical binding]; other site
857087007014	putative nucleic acid binding site [nucleotide binding]; other site
857087007015	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087007016	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087007017	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087007018	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087007019	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087007020	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087007021	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087007022	N-terminal plug; other site
857087007023	ligand-binding site [chemical binding]; other site
857087007024	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087007025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087007026	LysR substrate binding domain; Region: LysR_substrate; pfam03466
857087007027	dimerization interface [polypeptide binding]; other site
857087007028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087007029	putative substrate translocation pore; other site
857087007030	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
857087007031	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087007032	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
857087007033	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087007034	Transcriptional regulator; Region: Rrf2; cl17282
857087007035	Rrf2 family protein; Region: rrf2_super; TIGR00738
857087007036	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
857087007037	apolar tunnel; other site
857087007038	heme binding site [chemical binding]; other site
857087007039	dimerization interface [polypeptide binding]; other site
857087007040	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
857087007041	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
857087007042	FAD binding pocket [chemical binding]; other site
857087007043	conserved FAD binding motif [chemical binding]; other site
857087007044	phosphate binding motif [ion binding]; other site
857087007045	beta-alpha-beta structure motif; other site
857087007046	NAD binding pocket [chemical binding]; other site
857087007047	Rubredoxin [Energy production and conversion]; Region: COG1773
857087007048	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
857087007049	iron binding site [ion binding]; other site
857087007050	Cytochrome c; Region: Cytochrom_C; pfam00034
857087007051	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
857087007052	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
857087007053	Low-spin heme binding site [chemical binding]; other site
857087007054	D-pathway; other site
857087007055	Putative water exit pathway; other site
857087007056	Binuclear center (active site) [active]
857087007057	K-pathway; other site
857087007058	Putative proton exit pathway; other site
857087007059	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
857087007060	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087007061	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087007062	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087007063	RHS Repeat; Region: RHS_repeat; pfam05593
857087007064	RHS Repeat; Region: RHS_repeat; pfam05593
857087007065	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087007066	RHS Repeat; Region: RHS_repeat; pfam05593
857087007067	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087007068	RHS Repeat; Region: RHS_repeat; pfam05593
857087007069	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087007070	A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414
857087007071	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
857087007072	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
857087007073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087007074	S-adenosylmethionine binding site [chemical binding]; other site
857087007075	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
857087007076	active site clefts [active]
857087007077	zinc binding site [ion binding]; other site
857087007078	dimer interface [polypeptide binding]; other site
857087007079	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
857087007080	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087007081	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087007082	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
857087007083	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
857087007084	Walker A/P-loop; other site
857087007085	ATP binding site [chemical binding]; other site
857087007086	Q-loop/lid; other site
857087007087	ABC transporter signature motif; other site
857087007088	Walker B; other site
857087007089	D-loop; other site
857087007090	H-loop/switch region; other site
857087007091	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
857087007092	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
857087007093	Walker A/P-loop; other site
857087007094	ATP binding site [chemical binding]; other site
857087007095	Q-loop/lid; other site
857087007096	ABC transporter signature motif; other site
857087007097	Walker B; other site
857087007098	D-loop; other site
857087007099	H-loop/switch region; other site
857087007100	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
857087007101	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
857087007102	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
857087007103	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
857087007104	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
857087007105	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
857087007106	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
857087007107	Response regulator receiver domain; Region: Response_reg; pfam00072
857087007108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007109	active site
857087007110	phosphorylation site [posttranslational modification]
857087007111	intermolecular recognition site; other site
857087007112	dimerization interface [polypeptide binding]; other site
857087007113	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087007114	DNA binding residues [nucleotide binding]
857087007115	dimerization interface [polypeptide binding]; other site
857087007116	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
857087007117	Na binding site [ion binding]; other site
857087007118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087007119	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087007120	dimer interface [polypeptide binding]; other site
857087007121	phosphorylation site [posttranslational modification]
857087007122	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087007123	ATP binding site [chemical binding]; other site
857087007124	Mg2+ binding site [ion binding]; other site
857087007125	G-X-G motif; other site
857087007126	Response regulator receiver domain; Region: Response_reg; pfam00072
857087007127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007128	active site
857087007129	phosphorylation site [posttranslational modification]
857087007130	intermolecular recognition site; other site
857087007131	dimerization interface [polypeptide binding]; other site
857087007132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087007133	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
857087007134	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
857087007135	putative ligand binding site [chemical binding]; other site
857087007136	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
857087007137	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
857087007138	TM-ABC transporter signature motif; other site
857087007139	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
857087007140	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
857087007141	TM-ABC transporter signature motif; other site
857087007142	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
857087007143	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
857087007144	Walker A/P-loop; other site
857087007145	ATP binding site [chemical binding]; other site
857087007146	Q-loop/lid; other site
857087007147	ABC transporter signature motif; other site
857087007148	Walker B; other site
857087007149	D-loop; other site
857087007150	H-loop/switch region; other site
857087007151	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
857087007152	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
857087007153	Walker A/P-loop; other site
857087007154	ATP binding site [chemical binding]; other site
857087007155	Q-loop/lid; other site
857087007156	ABC transporter signature motif; other site
857087007157	Walker B; other site
857087007158	D-loop; other site
857087007159	H-loop/switch region; other site
857087007160	UreD urease accessory protein; Region: UreD; cl00530
857087007161	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
857087007162	alpha-gamma subunit interface [polypeptide binding]; other site
857087007163	beta-gamma subunit interface [polypeptide binding]; other site
857087007164	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
857087007165	gamma-beta subunit interface [polypeptide binding]; other site
857087007166	alpha-beta subunit interface [polypeptide binding]; other site
857087007167	urease subunit alpha; Reviewed; Region: ureC; PRK13207
857087007168	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
857087007169	subunit interactions [polypeptide binding]; other site
857087007170	active site
857087007171	flap region; other site
857087007172	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
857087007173	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
857087007174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087007175	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
857087007176	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
857087007177	dimer interface [polypeptide binding]; other site
857087007178	catalytic residues [active]
857087007179	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
857087007180	UreF; Region: UreF; pfam01730
857087007181	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087007182	G1 box; other site
857087007183	GTP/Mg2+ binding site [chemical binding]; other site
857087007184	G2 box; other site
857087007185	Switch I region; other site
857087007186	G3 box; other site
857087007187	Switch II region; other site
857087007188	G4 box; other site
857087007189	G5 box; other site
857087007190	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
857087007191	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
857087007192	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
857087007193	GAF domain; Region: GAF_2; pfam13185
857087007194	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
857087007195	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087007196	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087007197	metal binding site [ion binding]; metal-binding site
857087007198	active site
857087007199	I-site; other site
857087007200	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
857087007201	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
857087007202	substrate binding site [chemical binding]; other site
857087007203	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
857087007204	substrate binding site [chemical binding]; other site
857087007205	ligand binding site [chemical binding]; other site
857087007206	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
857087007207	putative active site [active]
857087007208	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
857087007209	isocitrate dehydrogenase; Validated; Region: PRK06451
857087007210	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
857087007211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087007212	Walker A/P-loop; other site
857087007213	ATP binding site [chemical binding]; other site
857087007214	Q-loop/lid; other site
857087007215	ABC transporter signature motif; other site
857087007216	Walker B; other site
857087007217	D-loop; other site
857087007218	H-loop/switch region; other site
857087007219	Ion transport protein; Region: Ion_trans; pfam00520
857087007220	Ion channel; Region: Ion_trans_2; pfam07885
857087007221	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
857087007222	murein L,D-transpeptidase; Provisional; Region: PRK10594
857087007223	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
857087007224	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
857087007225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
857087007226	Peptidase M15; Region: Peptidase_M15_3; cl01194
857087007227	acetylornithine aminotransferase; Provisional; Region: PRK02627
857087007228	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
857087007229	inhibitor-cofactor binding pocket; inhibition site
857087007230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007231	catalytic residue [active]
857087007232	ornithine carbamoyltransferase; Provisional; Region: PRK00779
857087007233	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
857087007234	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
857087007235	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
857087007236	Bacterial SH3 domain; Region: SH3_3; cl17532
857087007237	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
857087007238	Divergent AAA domain; Region: AAA_4; pfam04326
857087007239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087007240	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
857087007241	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
857087007242	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
857087007243	trimer interface [polypeptide binding]; other site
857087007244	active site
857087007245	UDP-GlcNAc binding site [chemical binding]; other site
857087007246	lipid binding site [chemical binding]; lipid-binding site
857087007247	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
857087007248	tetramer (dimer of dimers) interface [polypeptide binding]; other site
857087007249	active site
857087007250	dimer interface [polypeptide binding]; other site
857087007251	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
857087007252	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087007253	BNR repeat-like domain; Region: BNR_2; pfam13088
857087007254	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
857087007255	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
857087007256	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
857087007257	putative active site [active]
857087007258	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
857087007259	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
857087007260	putative active site [active]
857087007261	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
857087007262	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
857087007263	homodimer interface [polypeptide binding]; other site
857087007264	substrate-cofactor binding pocket; other site
857087007265	catalytic residue [active]
857087007266	Peptidase family M48; Region: Peptidase_M48; cl12018
857087007267	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
857087007268	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
857087007269	putative dimer interface [polypeptide binding]; other site
857087007270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087007271	dimerization interface [polypeptide binding]; other site
857087007272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
857087007273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087007274	dimer interface [polypeptide binding]; other site
857087007275	phosphorylation site [posttranslational modification]
857087007276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087007277	ATP binding site [chemical binding]; other site
857087007278	Mg2+ binding site [ion binding]; other site
857087007279	G-X-G motif; other site
857087007280	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087007281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007282	active site
857087007283	phosphorylation site [posttranslational modification]
857087007284	intermolecular recognition site; other site
857087007285	dimerization interface [polypeptide binding]; other site
857087007286	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087007287	DNA binding site [nucleotide binding]
857087007288	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
857087007289	dimer interface [polypeptide binding]; other site
857087007290	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087007291	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
857087007292	FtsX-like permease family; Region: FtsX; pfam02687
857087007293	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
857087007294	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087007295	Walker A/P-loop; other site
857087007296	ATP binding site [chemical binding]; other site
857087007297	Q-loop/lid; other site
857087007298	ABC transporter signature motif; other site
857087007299	Walker B; other site
857087007300	D-loop; other site
857087007301	H-loop/switch region; other site
857087007302	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087007303	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087007304	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
857087007305	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
857087007306	EF-hand domain pair; Region: EF_hand_5; pfam13499
857087007307	Ca2+ binding site [ion binding]; other site
857087007308	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
857087007309	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
857087007310	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
857087007311	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
857087007312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087007313	catalytic residue [active]
857087007314	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
857087007315	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
857087007316	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
857087007317	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
857087007318	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
857087007319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087007320	ATP binding site [chemical binding]; other site
857087007321	Mg2+ binding site [ion binding]; other site
857087007322	G-X-G motif; other site
857087007323	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
857087007324	ATP binding site [chemical binding]; other site
857087007325	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
857087007326	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
857087007327	AMIN domain; Region: AMIN; pfam11741
857087007328	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
857087007329	active site
857087007330	metal binding site [ion binding]; metal-binding site
857087007331	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
857087007332	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087007333	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
857087007334	Uncharacterized conserved protein [Function unknown]; Region: COG0062
857087007335	putative carbohydrate kinase; Provisional; Region: PRK10565
857087007336	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
857087007337	putative substrate binding site [chemical binding]; other site
857087007338	putative ATP binding site [chemical binding]; other site
857087007339	epoxyqueuosine reductase; Region: TIGR00276
857087007340	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
857087007341	aspartate aminotransferase; Provisional; Region: PRK05764
857087007342	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087007343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007344	homodimer interface [polypeptide binding]; other site
857087007345	catalytic residue [active]
857087007346	Uncharacterized conserved protein [Function unknown]; Region: COG1432
857087007347	LabA_like proteins; Region: LabA; cd10911
857087007348	putative metal binding site [ion binding]; other site
857087007349	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
857087007350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087007351	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
857087007352	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
857087007353	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
857087007354	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023
857087007355	active site
857087007356	HopJ type III effector protein; Region: HopJ; pfam08888
857087007357	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
857087007358	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
857087007359	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
857087007360	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
857087007361	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
857087007362	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
857087007363	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007364	binding surface
857087007365	TPR repeat; Region: TPR_11; pfam13414
857087007366	TPR motif; other site
857087007367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007368	TPR motif; other site
857087007369	binding surface
857087007370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007371	binding surface
857087007372	TPR motif; other site
857087007373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007374	binding surface
857087007375	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087007376	TPR motif; other site
857087007377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007378	binding surface
857087007379	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087007380	TPR motif; other site
857087007381	TPR repeat; Region: TPR_11; pfam13414
857087007382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007383	binding surface
857087007384	TPR motif; other site
857087007385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007386	binding surface
857087007387	TPR motif; other site
857087007388	TPR repeat; Region: TPR_11; pfam13414
857087007389	DAK2 domain; Region: Dak2; cl03685
857087007390	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
857087007391	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
857087007392	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
857087007393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087007394	active site
857087007395	motif I; other site
857087007396	motif II; other site
857087007397	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087007398	Autotransporter beta-domain; Region: Autotransporter; smart00869
857087007399	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
857087007400	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
857087007401	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
857087007402	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
857087007403	structural tetrad; other site
857087007404	FOG: WD40 repeat [General function prediction only]; Region: COG2319
857087007405	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
857087007406	structural tetrad; other site
857087007407	TIR domain; Region: TIR_2; pfam13676
857087007408	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
857087007409	nudix motif; other site
857087007410	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
857087007411	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
857087007412	putative active site [active]
857087007413	Zn binding site [ion binding]; other site
857087007414	carbon starvation protein A; Provisional; Region: PRK15015
857087007415	Carbon starvation protein CstA; Region: CstA; pfam02554
857087007416	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
857087007417	Major Facilitator Superfamily; Region: MFS_1; pfam07690
857087007418	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
857087007419	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
857087007420	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087007421	catalytic residue [active]
857087007422	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
857087007423	dihydropteroate synthase; Region: DHPS; TIGR01496
857087007424	substrate binding pocket [chemical binding]; other site
857087007425	dimer interface [polypeptide binding]; other site
857087007426	inhibitor binding site; inhibition site
857087007427	Domain of unknown function DUF87; Region: DUF87; pfam01935
857087007428	AAA-like domain; Region: AAA_10; pfam12846
857087007429	Protein of unknown function (DUF539); Region: DUF539; cl01129
857087007430	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
857087007431	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087007432	catalytic loop [active]
857087007433	iron binding site [ion binding]; other site
857087007434	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
857087007435	FAD binding pocket [chemical binding]; other site
857087007436	FAD binding motif [chemical binding]; other site
857087007437	phosphate binding motif [ion binding]; other site
857087007438	beta-alpha-beta structure motif; other site
857087007439	NAD binding pocket [chemical binding]; other site
857087007440	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
857087007441	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
857087007442	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
857087007443	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
857087007444	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
857087007445	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
857087007446	E3 interaction surface; other site
857087007447	lipoyl attachment site [posttranslational modification]; other site
857087007448	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
857087007449	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
857087007450	active site
857087007451	metal binding site [ion binding]; metal-binding site
857087007452	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
857087007453	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
857087007454	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
857087007455	NnrS protein; Region: NnrS; pfam05940
857087007456	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
857087007457	dinuclear metal binding motif [ion binding]; other site
857087007458	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
857087007459	Sporulation related domain; Region: SPOR; pfam05036
857087007460	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
857087007461	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
857087007462	putative active site [active]
857087007463	putative PHP Thumb interface [polypeptide binding]; other site
857087007464	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
857087007465	generic binding surface II; other site
857087007466	generic binding surface I; other site
857087007467	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
857087007468	RNA/DNA hybrid binding site [nucleotide binding]; other site
857087007469	active site
857087007470	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
857087007471	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
857087007472	active site
857087007473	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
857087007474	periplasmic chaperone; Provisional; Region: PRK10780
857087007475	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
857087007476	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
857087007477	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
857087007478	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
857087007479	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
857087007480	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
857087007481	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
857087007482	Surface antigen; Region: Bac_surface_Ag; pfam01103
857087007483	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
857087007484	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
857087007485	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
857087007486	Cytochrome c; Region: Cytochrom_C; cl11414
857087007487	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
857087007488	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
857087007489	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
857087007490	exoribonuclease R; Provisional; Region: PRK11642
857087007491	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
857087007492	RNB domain; Region: RNB; pfam00773
857087007493	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
857087007494	RNA binding site [nucleotide binding]; other site
857087007495	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
857087007496	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
857087007497	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
857087007498	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
857087007499	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
857087007500	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087007501	RNA binding surface [nucleotide binding]; other site
857087007502	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087007503	active site residue [active]
857087007504	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
857087007505	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
857087007506	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
857087007507	putative protease; Provisional; Region: PRK15452
857087007508	Peptidase family U32; Region: Peptidase_U32; pfam01136
857087007509	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
857087007510	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
857087007511	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
857087007512	substrate binding site; other site
857087007513	tetramer interface; other site
857087007514	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
857087007515	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
857087007516	NADP binding site [chemical binding]; other site
857087007517	active site
857087007518	putative substrate binding site [chemical binding]; other site
857087007519	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
857087007520	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
857087007521	NAD binding site [chemical binding]; other site
857087007522	substrate binding site [chemical binding]; other site
857087007523	homodimer interface [polypeptide binding]; other site
857087007524	active site
857087007525	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087007526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087007527	ATP binding site [chemical binding]; other site
857087007528	Mg2+ binding site [ion binding]; other site
857087007529	G-X-G motif; other site
857087007530	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087007531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007532	active site
857087007533	phosphorylation site [posttranslational modification]
857087007534	intermolecular recognition site; other site
857087007535	dimerization interface [polypeptide binding]; other site
857087007536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007537	binding surface
857087007538	TPR motif; other site
857087007539	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087007540	Coenzyme A binding pocket [chemical binding]; other site
857087007541	Putative addiction module component; Region: Unstab_antitox; pfam09720
857087007542	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
857087007543	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
857087007544	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
857087007545	Ligand binding site; other site
857087007546	oligomer interface; other site
857087007547	Uncharacterized conserved protein [Function unknown]; Region: COG2835
857087007548	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
857087007549	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
857087007550	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087007551	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
857087007552	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
857087007553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087007554	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
857087007555	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
857087007556	Tetramer interface [polypeptide binding]; other site
857087007557	active site
857087007558	FMN-binding site [chemical binding]; other site
857087007559	HemK family putative methylases; Region: hemK_fam; TIGR00536
857087007560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087007561	S-adenosylmethionine binding site [chemical binding]; other site
857087007562	HDOD domain; Region: HDOD; pfam08668
857087007563	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
857087007564	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
857087007565	metal binding site [ion binding]; metal-binding site
857087007566	putative dimer interface [polypeptide binding]; other site
857087007567	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
857087007568	active site
857087007569	metal binding site [ion binding]; metal-binding site
857087007570	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
857087007571	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
857087007572	oxaloacetate decarboxylase; Provisional; Region: PRK14040
857087007573	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
857087007574	active site
857087007575	catalytic residues [active]
857087007576	metal binding site [ion binding]; metal-binding site
857087007577	homodimer binding site [polypeptide binding]; other site
857087007578	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
857087007579	carboxyltransferase (CT) interaction site; other site
857087007580	biotinylation site [posttranslational modification]; other site
857087007581	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
857087007582	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
857087007583	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
857087007584	substrate binding site [chemical binding]; other site
857087007585	ATP binding site [chemical binding]; other site
857087007586	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087007587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087007588	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
857087007589	putative effector binding pocket; other site
857087007590	dimerization interface [polypeptide binding]; other site
857087007591	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
857087007592	Transglycosylase; Region: Transgly; pfam00912
857087007593	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
857087007594	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
857087007595	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
857087007596	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087007597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087007598	putative active site [active]
857087007599	heme pocket [chemical binding]; other site
857087007600	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087007601	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087007602	metal binding site [ion binding]; metal-binding site
857087007603	active site
857087007604	I-site; other site
857087007605	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087007606	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
857087007607	TSCPD domain; Region: TSCPD; pfam12637
857087007608	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
857087007609	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
857087007610	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
857087007611	active site
857087007612	dimer interface [polypeptide binding]; other site
857087007613	effector binding site; other site
857087007614	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
857087007615	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
857087007616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087007617	ATP binding site [chemical binding]; other site
857087007618	putative Mg++ binding site [ion binding]; other site
857087007619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087007620	nucleotide binding region [chemical binding]; other site
857087007621	ATP-binding site [chemical binding]; other site
857087007622	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
857087007623	CoA binding domain; Region: CoA_binding; smart00881
857087007624	CoA-ligase; Region: Ligase_CoA; pfam00549
857087007625	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
857087007626	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
857087007627	CoA-ligase; Region: Ligase_CoA; pfam00549
857087007628	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
857087007629	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
857087007630	homodimer interface [polypeptide binding]; other site
857087007631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007632	catalytic residue [active]
857087007633	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
857087007634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087007635	putative substrate translocation pore; other site
857087007636	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
857087007637	His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981
857087007638	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
857087007639	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
857087007640	dimerization interface [polypeptide binding]; other site
857087007641	ligand binding site [chemical binding]; other site
857087007642	NADP binding site [chemical binding]; other site
857087007643	catalytic site [active]
857087007644	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087007645	PEP-CTERM motif; Region: VPEP; pfam07589
857087007646	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
857087007647	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
857087007648	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
857087007649	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
857087007650	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
857087007651	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
857087007652	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
857087007653	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
857087007654	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
857087007655	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087007656	catalytic residues [active]
857087007657	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
857087007658	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087007659	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
857087007660	ApbE family; Region: ApbE; pfam02424
857087007661	malate dehydrogenase; Provisional; Region: PRK05442
857087007662	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
857087007663	NAD(P) binding site [chemical binding]; other site
857087007664	dimer interface [polypeptide binding]; other site
857087007665	malate binding site [chemical binding]; other site
857087007666	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
857087007667	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
857087007668	NADP binding site [chemical binding]; other site
857087007669	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
857087007670	MOFRL family; Region: MOFRL; pfam05161
857087007671	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
857087007672	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
857087007673	dimer interface [polypeptide binding]; other site
857087007674	active site
857087007675	glycine-pyridoxal phosphate binding site [chemical binding]; other site
857087007676	folate binding site [chemical binding]; other site
857087007677	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087007678	Cytochrome c; Region: Cytochrom_C; cl11414
857087007679	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
857087007680	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
857087007681	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
857087007682	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
857087007683	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
857087007684	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087007685	active site
857087007686	motif I; other site
857087007687	motif II; other site
857087007688	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
857087007689	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
857087007690	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
857087007691	active site
857087007692	homodimer interface [polypeptide binding]; other site
857087007693	catalytic site [active]
857087007694	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
857087007695	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087007696	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
857087007697	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087007698	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087007699	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087007700	N-terminal plug; other site
857087007701	ligand-binding site [chemical binding]; other site
857087007702	fec operon regulator FecR; Reviewed; Region: PRK09774
857087007703	FecR protein; Region: FecR; pfam04773
857087007704	RNA polymerase sigma factor; Provisional; Region: PRK12528
857087007705	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087007706	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087007707	DNA binding residues [nucleotide binding]
857087007708	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087007709	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087007710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
857087007711	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
857087007712	fec operon regulator FecR; Reviewed; Region: PRK09774
857087007713	FecR protein; Region: FecR; pfam04773
857087007714	RNA polymerase sigma factor; Provisional; Region: PRK12528
857087007715	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087007716	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087007717	DNA binding residues [nucleotide binding]
857087007718	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
857087007719	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
857087007720	tetramer interface [polypeptide binding]; other site
857087007721	active site
857087007722	Mg2+/Mn2+ binding site [ion binding]; other site
857087007723	enterobactin exporter EntS; Provisional; Region: PRK10489
857087007724	Protein of unknown function (DUF2452); Region: DUF2452; pfam10504
857087007725	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
857087007726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
857087007727	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
857087007728	active site
857087007729	Domain of unknown function (DUF1287); Region: DUF1287; pfam06940
857087007730	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
857087007731	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
857087007732	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
857087007733	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
857087007734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007735	binding surface
857087007736	TPR motif; other site
857087007737	TPR repeat; Region: TPR_11; pfam13414
857087007738	TPR repeat; Region: TPR_11; pfam13414
857087007739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007740	binding surface
857087007741	TPR motif; other site
857087007742	TPR repeat; Region: TPR_11; pfam13414
857087007743	TPR repeat; Region: TPR_11; pfam13414
857087007744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087007745	binding surface
857087007746	TPR motif; other site
857087007747	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087007748	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
857087007749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007750	active site
857087007751	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
857087007752	phosphorylation site [posttranslational modification]
857087007753	intermolecular recognition site; other site
857087007754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007755	active site
857087007756	phosphorylation site [posttranslational modification]
857087007757	intermolecular recognition site; other site
857087007758	dimerization interface [polypeptide binding]; other site
857087007759	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087007760	metal binding site [ion binding]; metal-binding site
857087007761	active site
857087007762	I-site; other site
857087007763	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087007764	Zn2+ binding site [ion binding]; other site
857087007765	Mg2+ binding site [ion binding]; other site
857087007766	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087007767	Zn2+ binding site [ion binding]; other site
857087007768	Mg2+ binding site [ion binding]; other site
857087007769	replicative DNA helicase; Region: DnaB; TIGR00665
857087007770	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
857087007771	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
857087007772	Walker A motif; other site
857087007773	ATP binding site [chemical binding]; other site
857087007774	Walker B motif; other site
857087007775	DNA binding loops [nucleotide binding]
857087007776	alanine racemase; Reviewed; Region: alr; PRK00053
857087007777	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
857087007778	active site
857087007779	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087007780	substrate binding site [chemical binding]; other site
857087007781	catalytic residues [active]
857087007782	dimer interface [polypeptide binding]; other site
857087007783	DNA repair protein RadA; Provisional; Region: PRK11823
857087007784	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
857087007785	Walker A motif/ATP binding site; other site
857087007786	ATP binding site [chemical binding]; other site
857087007787	Walker B motif; other site
857087007788	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
857087007789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087007790	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087007791	PilZ domain; Region: PilZ; pfam07238
857087007792	FHA domain; Region: FHA; pfam00498
857087007793	phosphopeptide binding site; other site
857087007794	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
857087007795	phosphopeptide binding site; other site
857087007796	phosphate acetyltransferase; Reviewed; Region: PRK05632
857087007797	DRTGG domain; Region: DRTGG; pfam07085
857087007798	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
857087007799	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
857087007800	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
857087007801	propionate/acetate kinase; Provisional; Region: PRK12379
857087007802	HDOD domain; Region: HDOD; pfam08668
857087007803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087007804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087007805	ATP binding site [chemical binding]; other site
857087007806	Mg2+ binding site [ion binding]; other site
857087007807	G-X-G motif; other site
857087007808	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
857087007809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087007810	active site
857087007811	phosphorylation site [posttranslational modification]
857087007812	intermolecular recognition site; other site
857087007813	dimerization interface [polypeptide binding]; other site
857087007814	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087007815	Predicted integral membrane protein [Function unknown]; Region: COG5652
857087007816	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
857087007817	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
857087007818	putative active site [active]
857087007819	putative FMN binding site [chemical binding]; other site
857087007820	putative substrate binding site [chemical binding]; other site
857087007821	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
857087007822	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
857087007823	dimer interface [polypeptide binding]; other site
857087007824	PYR/PP interface [polypeptide binding]; other site
857087007825	TPP binding site [chemical binding]; other site
857087007826	substrate binding site [chemical binding]; other site
857087007827	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
857087007828	Domain of unknown function; Region: EKR; pfam10371
857087007829	4Fe-4S binding domain; Region: Fer4_6; pfam12837
857087007830	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
857087007831	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
857087007832	TPP-binding site [chemical binding]; other site
857087007833	dimer interface [polypeptide binding]; other site
857087007834	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
857087007835	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
857087007836	NADP binding site [chemical binding]; other site
857087007837	homodimer interface [polypeptide binding]; other site
857087007838	active site
857087007839	Uncharacterized conserved protein [Function unknown]; Region: COG4278
857087007840	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087007841	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087007842	ligand binding site [chemical binding]; other site
857087007843	flexible hinge region; other site
857087007844	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087007845	non-specific DNA interactions [nucleotide binding]; other site
857087007846	DNA binding site [nucleotide binding]
857087007847	sequence specific DNA binding site [nucleotide binding]; other site
857087007848	putative cAMP binding site [chemical binding]; other site
857087007849	FOG: CBS domain [General function prediction only]; Region: COG0517
857087007850	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
857087007851	HDOD domain; Region: HDOD; pfam08668
857087007852	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
857087007853	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
857087007854	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
857087007855	dimer interface [polypeptide binding]; other site
857087007856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007857	catalytic residue [active]
857087007858	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
857087007859	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
857087007860	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
857087007861	protein binding site [polypeptide binding]; other site
857087007862	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
857087007863	protein binding site [polypeptide binding]; other site
857087007864	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
857087007865	anti-sigma E factor; Provisional; Region: rseB; PRK09455
857087007866	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
857087007867	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
857087007868	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087007869	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087007870	DNA binding residues [nucleotide binding]
857087007871	L-aspartate oxidase; Provisional; Region: PRK09077
857087007872	L-aspartate oxidase; Provisional; Region: PRK06175
857087007873	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
857087007874	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087007875	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
857087007876	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
857087007877	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
857087007878	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
857087007879	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
857087007880	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
857087007881	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
857087007882	general secretion pathway protein J; Validated; Region: PRK08808
857087007883	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
857087007884	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
857087007885	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
857087007886	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
857087007887	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
857087007888	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
857087007889	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
857087007890	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087007891	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
857087007892	HflC protein; Region: hflC; TIGR01932
857087007893	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
857087007894	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
857087007895	HflK protein; Region: hflK; TIGR01933
857087007896	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
857087007897	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
857087007898	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
857087007899	HNH endonuclease; Region: HNH_2; pfam13391
857087007900	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
857087007901	HicB family; Region: HicB; pfam05534
857087007902	YcfA-like protein; Region: YcfA; cl00752
857087007903	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
857087007904	Methyltransferase domain; Region: Methyltransf_26; pfam13659
857087007905	DEAD-like helicases superfamily; Region: DEXDc; smart00487
857087007906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087007907	ATP binding site [chemical binding]; other site
857087007908	putative Mg++ binding site [ion binding]; other site
857087007909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087007910	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
857087007911	nucleotide binding region [chemical binding]; other site
857087007912	ATP-binding site [chemical binding]; other site
857087007913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
857087007914	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
857087007915	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
857087007916	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
857087007917	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
857087007918	Putative phage integrase; Region: Phage_Integr_2; pfam13009
857087007919	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
857087007920	DNA binding site [nucleotide binding]
857087007921	active site
857087007922	Int/Topo IB signature motif; other site
857087007923	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
857087007924	DNA binding site [nucleotide binding]
857087007925	active site
857087007926	Int/Topo IB signature motif; other site
857087007927	catalytic residues [active]
857087007928	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
857087007929	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
857087007930	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
857087007931	putative active site pocket [active]
857087007932	dimerization interface [polypeptide binding]; other site
857087007933	putative catalytic residue [active]
857087007934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087007935	PAS domain; Region: PAS_9; pfam13426
857087007936	putative active site [active]
857087007937	heme pocket [chemical binding]; other site
857087007938	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087007939	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087007940	metal binding site [ion binding]; metal-binding site
857087007941	active site
857087007942	I-site; other site
857087007943	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087007944	Hemerythrin; Region: Hemerythrin; cd12107
857087007945	Fe binding site [ion binding]; other site
857087007946	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
857087007947	putative active site [active]
857087007948	dimerization interface [polypeptide binding]; other site
857087007949	putative tRNAtyr binding site [nucleotide binding]; other site
857087007950	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
857087007951	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
857087007952	dimerization interface [polypeptide binding]; other site
857087007953	ATP binding site [chemical binding]; other site
857087007954	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
857087007955	dimerization interface [polypeptide binding]; other site
857087007956	ATP binding site [chemical binding]; other site
857087007957	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
857087007958	putative active site [active]
857087007959	catalytic triad [active]
857087007960	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
857087007961	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
857087007962	dihydrodipicolinate synthase; Region: dapA; TIGR00674
857087007963	dimer interface [polypeptide binding]; other site
857087007964	active site
857087007965	catalytic residue [active]
857087007966	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
857087007967	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
857087007968	active site
857087007969	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
857087007970	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
857087007971	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
857087007972	DHH family; Region: DHH; pfam01368
857087007973	DHHA1 domain; Region: DHHA1; pfam02272
857087007974	threonine synthase; Reviewed; Region: PRK06721
857087007975	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
857087007976	homodimer interface [polypeptide binding]; other site
857087007977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007978	catalytic residue [active]
857087007979	homoserine dehydrogenase; Provisional; Region: PRK06349
857087007980	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
857087007981	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
857087007982	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
857087007983	aminotransferase; Validated; Region: PRK08175
857087007984	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087007985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087007986	homodimer interface [polypeptide binding]; other site
857087007987	catalytic residue [active]
857087007988	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
857087007989	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
857087007990	GDP-binding site [chemical binding]; other site
857087007991	ACT binding site; other site
857087007992	IMP binding site; other site
857087007993	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
857087007994	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
857087007995	dimer interface [polypeptide binding]; other site
857087007996	motif 1; other site
857087007997	active site
857087007998	motif 2; other site
857087007999	motif 3; other site
857087008000	HflC protein; Region: hflC; TIGR01932
857087008001	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
857087008002	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
857087008003	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
857087008004	HflK protein; Region: hflK; TIGR01933
857087008005	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
857087008006	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
857087008007	HflX GTPase family; Region: HflX; cd01878
857087008008	G1 box; other site
857087008009	GTP/Mg2+ binding site [chemical binding]; other site
857087008010	Switch I region; other site
857087008011	G2 box; other site
857087008012	G3 box; other site
857087008013	Switch II region; other site
857087008014	G4 box; other site
857087008015	G5 box; other site
857087008016	bacterial Hfq-like; Region: Hfq; cd01716
857087008017	hexamer interface [polypeptide binding]; other site
857087008018	Sm1 motif; other site
857087008019	RNA binding site [nucleotide binding]; other site
857087008020	Sm2 motif; other site
857087008021	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
857087008022	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087008023	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087008024	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
857087008025	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
857087008026	active site
857087008027	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
857087008028	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
857087008029	putative ATP binding site [chemical binding]; other site
857087008030	putative substrate interface [chemical binding]; other site
857087008031	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
857087008032	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
857087008033	TOBE domain; Region: TOBE; cl01440
857087008034	TOBE domain; Region: TOBE; cl01440
857087008035	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
857087008036	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087008037	DNA-binding site [nucleotide binding]; DNA binding site
857087008038	RNA-binding motif; other site
857087008039	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
857087008040	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087008041	HSP70 interaction site [polypeptide binding]; other site
857087008042	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
857087008043	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087008044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008045	Walker A motif; other site
857087008046	ATP binding site [chemical binding]; other site
857087008047	Walker B motif; other site
857087008048	arginine finger; other site
857087008049	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
857087008050	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
857087008051	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087008052	Coenzyme A binding pocket [chemical binding]; other site
857087008053	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
857087008054	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008055	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008056	DNA binding residues [nucleotide binding]
857087008057	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008058	FecR protein; Region: FecR; pfam04773
857087008059	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008060	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008061	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008062	N-terminal plug; other site
857087008063	ligand-binding site [chemical binding]; other site
857087008064	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
857087008065	oligomeric interface; other site
857087008066	putative active site [active]
857087008067	homodimer interface [polypeptide binding]; other site
857087008068	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
857087008069	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
857087008070	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
857087008071	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087008072	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
857087008073	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008074	RNA polymerase sigma factor; Reviewed; Region: PRK12527
857087008075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008076	DNA binding residues [nucleotide binding]
857087008077	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008078	FecR protein; Region: FecR; pfam04773
857087008079	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008080	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008081	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008082	N-terminal plug; other site
857087008083	ligand-binding site [chemical binding]; other site
857087008084	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
857087008085	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087008086	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087008087	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
857087008088	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
857087008089	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
857087008090	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008091	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008092	DNA binding residues [nucleotide binding]
857087008093	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008094	FecR protein; Region: FecR; pfam04773
857087008095	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008096	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008097	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008098	N-terminal plug; other site
857087008099	ligand-binding site [chemical binding]; other site
857087008100	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
857087008101	putative active site [active]
857087008102	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087008103	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008104	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008105	DNA binding residues [nucleotide binding]
857087008106	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008107	FecR protein; Region: FecR; pfam04773
857087008108	Transposase IS200 like; Region: Y1_Tnp; pfam01797
857087008109	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008110	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008111	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008112	N-terminal plug; other site
857087008113	ligand-binding site [chemical binding]; other site
857087008114	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087008115	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087008116	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087008117	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
857087008118	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008119	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008120	DNA binding residues [nucleotide binding]
857087008121	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008122	FecR protein; Region: FecR; pfam04773
857087008123	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087008124	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008125	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008126	DNA binding residues [nucleotide binding]
857087008127	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008128	FecR protein; Region: FecR; pfam04773
857087008129	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008130	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008131	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008132	N-terminal plug; other site
857087008133	ligand-binding site [chemical binding]; other site
857087008134	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087008135	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087008136	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087008137	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087008138	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008139	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008140	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008141	N-terminal plug; other site
857087008142	ligand-binding site [chemical binding]; other site
857087008143	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008144	RNA polymerase sigma factor; Reviewed; Region: PRK12527
857087008145	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008146	DNA binding residues [nucleotide binding]
857087008147	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008148	FecR protein; Region: FecR; pfam04773
857087008149	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008150	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008151	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008152	N-terminal plug; other site
857087008153	ligand-binding site [chemical binding]; other site
857087008154	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087008155	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
857087008156	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087008157	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087008158	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087008159	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008160	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008161	DNA binding residues [nucleotide binding]
857087008162	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008163	FecR protein; Region: FecR; pfam04773
857087008164	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008165	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
857087008166	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008167	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008168	N-terminal plug; other site
857087008169	ligand-binding site [chemical binding]; other site
857087008170	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087008171	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008172	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008173	DNA binding residues [nucleotide binding]
857087008174	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008175	FecR protein; Region: FecR; pfam04773
857087008176	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008177	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008178	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008179	N-terminal plug; other site
857087008180	ligand-binding site [chemical binding]; other site
857087008181	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
857087008182	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008183	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008184	DNA binding residues [nucleotide binding]
857087008185	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008186	FecR protein; Region: FecR; pfam04773
857087008187	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008188	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008189	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008190	N-terminal plug; other site
857087008191	ligand-binding site [chemical binding]; other site
857087008192	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
857087008193	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087008194	FeS/SAM binding site; other site
857087008195	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
857087008196	putative ligand binding pocket/active site [active]
857087008197	putative metal binding site [ion binding]; other site
857087008198	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
857087008199	AMMECR1; Region: AMMECR1; pfam01871
857087008200	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
857087008201	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
857087008202	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
857087008203	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
857087008204	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
857087008205	putative active site [active]
857087008206	OpgC protein; Region: OpgC_C; pfam10129
857087008207	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
857087008208	phosphogluconate dehydratase; Validated; Region: PRK09054
857087008209	6-phosphogluconate dehydratase; Region: edd; TIGR01196
857087008210	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
857087008211	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
857087008212	active site
857087008213	intersubunit interface [polypeptide binding]; other site
857087008214	catalytic residue [active]
857087008215	hypothetical protein; Provisional; Region: PRK10039
857087008216	Transposase; Region: HTH_Tnp_1; cl17663
857087008217	Transposase; Region: HTH_Tnp_1; cl17663
857087008218	Homeodomain-like domain; Region: HTH_32; pfam13565
857087008219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
857087008220	Integrase core domain; Region: rve; pfam00665
857087008221	Integrase core domain; Region: rve_3; pfam13683
857087008222	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
857087008223	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
857087008224	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
857087008225	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
857087008226	NlpE N-terminal domain; Region: NlpE; pfam04170
857087008227	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
857087008228	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
857087008229	putative catalytic residue [active]
857087008230	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
857087008231	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087008232	active site
857087008233	ATP binding site [chemical binding]; other site
857087008234	substrate binding site [chemical binding]; other site
857087008235	activation loop (A-loop); other site
857087008236	Predicted ATPase [General function prediction only]; Region: COG3899
857087008237	AAA ATPase domain; Region: AAA_16; pfam13191
857087008238	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087008239	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
857087008240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087008241	dimer interface [polypeptide binding]; other site
857087008242	phosphorylation site [posttranslational modification]
857087008243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087008244	ATP binding site [chemical binding]; other site
857087008245	Mg2+ binding site [ion binding]; other site
857087008246	G-X-G motif; other site
857087008247	Response regulator receiver domain; Region: Response_reg; pfam00072
857087008248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008249	active site
857087008250	phosphorylation site [posttranslational modification]
857087008251	intermolecular recognition site; other site
857087008252	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087008253	PAS domain S-box; Region: sensory_box; TIGR00229
857087008254	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008256	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087008257	putative active site [active]
857087008258	heme pocket [chemical binding]; other site
857087008259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008260	putative active site [active]
857087008261	heme pocket [chemical binding]; other site
857087008262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008264	metal binding site [ion binding]; metal-binding site
857087008265	active site
857087008266	I-site; other site
857087008267	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087008268	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
857087008269	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
857087008270	substrate binding site [chemical binding]; other site
857087008271	hexamer interface [polypeptide binding]; other site
857087008272	metal binding site [ion binding]; metal-binding site
857087008273	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
857087008274	active site
857087008275	substrate binding site [chemical binding]; other site
857087008276	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
857087008277	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087008278	ATP binding site [chemical binding]; other site
857087008279	putative Mg++ binding site [ion binding]; other site
857087008280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087008281	nucleotide binding region [chemical binding]; other site
857087008282	ATP-binding site [chemical binding]; other site
857087008283	Part of AAA domain; Region: AAA_19; pfam13245
857087008284	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
857087008285	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
857087008286	Family description; Region: UvrD_C_2; pfam13538
857087008287	Transposase IS200 like; Region: Y1_Tnp; cl00848
857087008288	TIR domain; Region: TIR_2; pfam13676
857087008289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087008290	Transposase; Region: HTH_Tnp_1; pfam01527
857087008291	putative transposase OrfB; Reviewed; Region: PHA02517
857087008292	HTH-like domain; Region: HTH_21; pfam13276
857087008293	Integrase core domain; Region: rve; pfam00665
857087008294	Integrase core domain; Region: rve_3; pfam13683
857087008295	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
857087008296	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073
857087008297	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
857087008298	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
857087008299	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
857087008300	PAS domain S-box; Region: sensory_box; TIGR00229
857087008301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008302	putative active site [active]
857087008303	heme pocket [chemical binding]; other site
857087008304	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008305	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008306	metal binding site [ion binding]; metal-binding site
857087008307	active site
857087008308	I-site; other site
857087008309	glutamine synthetase; Provisional; Region: glnA; PRK09469
857087008310	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
857087008311	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
857087008312	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
857087008313	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
857087008314	Nitrogen regulatory protein P-II; Region: P-II; smart00938
857087008315	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
857087008316	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
857087008317	Nitrogen regulatory protein P-II; Region: P-II; smart00938
857087008318	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
857087008319	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
857087008320	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
857087008321	active site
857087008322	dimerization interface [polypeptide binding]; other site
857087008323	Sensory domain found in PocR; Region: PocR; pfam10114
857087008324	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
857087008325	PAS domain S-box; Region: sensory_box; TIGR00229
857087008326	PAS domain; Region: PAS; smart00091
857087008327	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087008328	GAF domain; Region: GAF; pfam01590
857087008329	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008330	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008331	metal binding site [ion binding]; metal-binding site
857087008332	active site
857087008333	I-site; other site
857087008334	Hemerythrin; Region: Hemerythrin; cd12107
857087008335	Fe binding site [ion binding]; other site
857087008336	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
857087008337	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087008338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087008339	Walker A/P-loop; other site
857087008340	ATP binding site [chemical binding]; other site
857087008341	Q-loop/lid; other site
857087008342	ABC transporter signature motif; other site
857087008343	Walker B; other site
857087008344	D-loop; other site
857087008345	H-loop/switch region; other site
857087008346	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
857087008347	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
857087008348	putative NAD(P) binding site [chemical binding]; other site
857087008349	Family description; Region: DsbD_2; pfam13386
857087008350	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
857087008351	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
857087008352	metal-binding site [ion binding]
857087008353	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
857087008354	Soluble P-type ATPase [General function prediction only]; Region: COG4087
857087008355	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
857087008356	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
857087008357	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
857087008358	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
857087008359	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
857087008360	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
857087008361	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
857087008362	Walker A motif/ATP binding site; other site
857087008363	Walker B motif; other site
857087008364	flagellar assembly protein H; Validated; Region: fliH; PRK05687
857087008365	Flagellar assembly protein FliH; Region: FliH; pfam02108
857087008366	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
857087008367	MgtE intracellular N domain; Region: MgtE_N; smart00924
857087008368	FliG C-terminal domain; Region: FliG_C; pfam01706
857087008369	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
857087008370	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
857087008371	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
857087008372	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
857087008373	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087008374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008375	active site
857087008376	phosphorylation site [posttranslational modification]
857087008377	intermolecular recognition site; other site
857087008378	dimerization interface [polypeptide binding]; other site
857087008379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008380	Walker A motif; other site
857087008381	ATP binding site [chemical binding]; other site
857087008382	Walker B motif; other site
857087008383	arginine finger; other site
857087008384	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087008385	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087008386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087008387	dimer interface [polypeptide binding]; other site
857087008388	phosphorylation site [posttranslational modification]
857087008389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087008390	ATP binding site [chemical binding]; other site
857087008391	G-X-G motif; other site
857087008392	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087008393	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
857087008394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008395	Walker A motif; other site
857087008396	ATP binding site [chemical binding]; other site
857087008397	Walker B motif; other site
857087008398	arginine finger; other site
857087008399	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087008400	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
857087008401	Domain of unknown function DUF21; Region: DUF21; pfam01595
857087008402	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
857087008403	Transporter associated domain; Region: CorC_HlyC; smart01091
857087008404	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
857087008405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087008406	S-adenosylmethionine binding site [chemical binding]; other site
857087008407	phosphoglycolate phosphatase; Provisional; Region: PRK13222
857087008408	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087008409	motif II; other site
857087008410	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087008411	NAD(P) binding site [chemical binding]; other site
857087008412	active site
857087008413	Domain of unknown function DUF59; Region: DUF59; cl00941
857087008414	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008415	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008416	metal binding site [ion binding]; metal-binding site
857087008417	active site
857087008418	I-site; other site
857087008419	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
857087008420	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
857087008421	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
857087008422	Transglycosylase; Region: Transgly; pfam00912
857087008423	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
857087008424	PilZ domain; Region: PilZ; pfam07238
857087008425	SprA-related family; Region: SprA-related; pfam12118
857087008426	excinuclease ABC subunit B; Provisional; Region: PRK05298
857087008427	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087008428	ATP binding site [chemical binding]; other site
857087008429	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087008430	nucleotide binding region [chemical binding]; other site
857087008431	ATP-binding site [chemical binding]; other site
857087008432	Ultra-violet resistance protein B; Region: UvrB; pfam12344
857087008433	UvrB/uvrC motif; Region: UVR; pfam02151
857087008434	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087008435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008436	active site
857087008437	phosphorylation site [posttranslational modification]
857087008438	intermolecular recognition site; other site
857087008439	dimerization interface [polypeptide binding]; other site
857087008440	Response regulator receiver domain; Region: Response_reg; pfam00072
857087008441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008442	active site
857087008443	phosphorylation site [posttranslational modification]
857087008444	intermolecular recognition site; other site
857087008445	dimerization interface [polypeptide binding]; other site
857087008446	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008447	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008448	metal binding site [ion binding]; metal-binding site
857087008449	active site
857087008450	I-site; other site
857087008451	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087008452	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
857087008453	Part of AAA domain; Region: AAA_19; pfam13245
857087008454	Family description; Region: UvrD_C_2; pfam13538
857087008455	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
857087008456	AAA domain; Region: AAA_30; pfam13604
857087008457	Family description; Region: UvrD_C_2; pfam13538
857087008458	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
857087008459	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
857087008460	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
857087008461	heme binding site [chemical binding]; other site
857087008462	ferroxidase pore; other site
857087008463	ferroxidase diiron center [ion binding]; other site
857087008464	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
857087008465	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
857087008466	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
857087008467	putative active site [active]
857087008468	putative metal binding site [ion binding]; other site
857087008469	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
857087008470	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
857087008471	EamA-like transporter family; Region: EamA; pfam00892
857087008472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087008473	Response regulator receiver domain; Region: Response_reg; pfam00072
857087008474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008475	active site
857087008476	phosphorylation site [posttranslational modification]
857087008477	intermolecular recognition site; other site
857087008478	dimerization interface [polypeptide binding]; other site
857087008479	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008480	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008481	metal binding site [ion binding]; metal-binding site
857087008482	active site
857087008483	I-site; other site
857087008484	CHASE domain; Region: CHASE; pfam03924
857087008485	PAS domain S-box; Region: sensory_box; TIGR00229
857087008486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008487	putative active site [active]
857087008488	heme pocket [chemical binding]; other site
857087008489	PAS fold; Region: PAS_4; pfam08448
857087008490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008491	putative active site [active]
857087008492	heme pocket [chemical binding]; other site
857087008493	PAS domain; Region: PAS_9; pfam13426
857087008494	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008495	putative active site [active]
857087008496	heme pocket [chemical binding]; other site
857087008497	PAS fold; Region: PAS; pfam00989
857087008498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008499	putative active site [active]
857087008500	heme pocket [chemical binding]; other site
857087008501	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087008502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087008503	dimer interface [polypeptide binding]; other site
857087008504	phosphorylation site [posttranslational modification]
857087008505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087008506	ATP binding site [chemical binding]; other site
857087008507	Mg2+ binding site [ion binding]; other site
857087008508	G-X-G motif; other site
857087008509	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087008510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087008511	active site
857087008512	phosphorylation site [posttranslational modification]
857087008513	intermolecular recognition site; other site
857087008514	dimerization interface [polypeptide binding]; other site
857087008515	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087008516	putative binding surface; other site
857087008517	active site
857087008518	B12 binding domain; Region: B12-binding; pfam02310
857087008519	B12 binding site [chemical binding]; other site
857087008520	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
857087008521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087008522	FeS/SAM binding site; other site
857087008523	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
857087008524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087008525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087008526	putative transposase OrfB; Reviewed; Region: PHA02517
857087008527	Homeodomain-like domain; Region: HTH_32; pfam13565
857087008528	Integrase core domain; Region: rve; pfam00665
857087008529	Integrase core domain; Region: rve_3; pfam13683
857087008530	Transposase; Region: HTH_Tnp_1; cl17663
857087008531	Transposase; Region: HTH_Tnp_1; cl17663
857087008532	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
857087008533	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
857087008534	putative uracil binding site [chemical binding]; other site
857087008535	putative active site [active]
857087008536	Protein of unknown function (DUF805); Region: DUF805; cl01224
857087008537	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
857087008538	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
857087008539	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
857087008540	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
857087008541	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
857087008542	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
857087008543	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
857087008544	inhibitor-cofactor binding pocket; inhibition site
857087008545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087008546	catalytic residue [active]
857087008547	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
857087008548	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
857087008549	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
857087008550	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
857087008551	metal-binding site [ion binding]
857087008552	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
857087008553	Soluble P-type ATPase [General function prediction only]; Region: COG4087
857087008554	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
857087008555	metal-binding site [ion binding]
857087008556	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
857087008557	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087008558	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087008559	active site residue [active]
857087008560	putative lysogenization regulator; Reviewed; Region: PRK00218
857087008561	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
857087008562	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
857087008563	DNA binding site [nucleotide binding]
857087008564	catalytic residue [active]
857087008565	H2TH interface [polypeptide binding]; other site
857087008566	putative catalytic residues [active]
857087008567	turnover-facilitating residue; other site
857087008568	intercalation triad [nucleotide binding]; other site
857087008569	8OG recognition residue [nucleotide binding]; other site
857087008570	putative reading head residues; other site
857087008571	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
857087008572	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
857087008573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
857087008574	active site
857087008575	phosphorylation site [posttranslational modification]
857087008576	dimerization interface [polypeptide binding]; other site
857087008577	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
857087008578	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
857087008579	TIGR02647 family protein; Region: DNA
857087008580	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
857087008581	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
857087008582	Domain of unknown function DUF20; Region: UPF0118; pfam01594
857087008583	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087008584	DNA-binding site [nucleotide binding]; DNA binding site
857087008585	RNA-binding motif; other site
857087008586	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
857087008587	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
857087008588	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
857087008589	homodimer interface [polypeptide binding]; other site
857087008590	Walker A motif; other site
857087008591	ATP binding site [chemical binding]; other site
857087008592	hydroxycobalamin binding site [chemical binding]; other site
857087008593	Walker B motif; other site
857087008594	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087008595	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
857087008596	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
857087008597	catalytic triad [active]
857087008598	Uncharacterized conserved protein [Function unknown]; Region: COG4095
857087008599	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
857087008600	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
857087008601	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
857087008602	thioredoxin reductase; Provisional; Region: PRK10262
857087008603	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
857087008604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087008605	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
857087008606	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
857087008607	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
857087008608	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
857087008609	elongation factor P; Provisional; Region: PRK04542
857087008610	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
857087008611	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
857087008612	RNA binding site [nucleotide binding]; other site
857087008613	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
857087008614	RNA binding site [nucleotide binding]; other site
857087008615	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
857087008616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
857087008617	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
857087008618	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
857087008619	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
857087008620	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
857087008621	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
857087008622	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
857087008623	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
857087008624	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
857087008625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087008626	Transposase; Region: HTH_Tnp_1; pfam01527
857087008627	putative transposase OrfB; Reviewed; Region: PHA02517
857087008628	HTH-like domain; Region: HTH_21; pfam13276
857087008629	Integrase core domain; Region: rve; pfam00665
857087008630	Integrase core domain; Region: rve_3; pfam13683
857087008631	Homeodomain-like domain; Region: HTH_32; pfam13565
857087008632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
857087008633	Integrase core domain; Region: rve; pfam00665
857087008634	Integrase core domain; Region: rve_3; pfam13683
857087008635	Transposase; Region: HTH_Tnp_1; cl17663
857087008636	Transposase; Region: HTH_Tnp_1; cl17663
857087008637	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087008638	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087008639	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087008640	N-terminal plug; other site
857087008641	ligand-binding site [chemical binding]; other site
857087008642	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087008643	FecR protein; Region: FecR; pfam04773
857087008644	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087008645	RNA polymerase sigma factor; Reviewed; Region: PRK12527
857087008646	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087008647	DNA binding residues [nucleotide binding]
857087008648	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
857087008649	rRNA binding site [nucleotide binding]; other site
857087008650	predicted 30S ribosome binding site; other site
857087008651	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
857087008652	Clp amino terminal domain; Region: Clp_N; pfam02861
857087008653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008654	Walker A motif; other site
857087008655	ATP binding site [chemical binding]; other site
857087008656	Walker B motif; other site
857087008657	arginine finger; other site
857087008658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008659	Walker A motif; other site
857087008660	ATP binding site [chemical binding]; other site
857087008661	Walker B motif; other site
857087008662	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
857087008663	Uncharacterized conserved protein [Function unknown]; Region: COG2127
857087008664	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
857087008665	nudix motif; other site
857087008666	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
857087008667	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
857087008668	Ligand Binding Site [chemical binding]; other site
857087008669	adenylosuccinate lyase; Provisional; Region: PRK09285
857087008670	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
857087008671	tetramer interface [polypeptide binding]; other site
857087008672	active site
857087008673	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
857087008674	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
857087008675	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
857087008676	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
857087008677	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087008678	FeS/SAM binding site; other site
857087008679	VacJ like lipoprotein; Region: VacJ; cl01073
857087008680	VacJ like lipoprotein; Region: VacJ; cl01073
857087008681	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
857087008682	dimer interface [polypeptide binding]; other site
857087008683	catalytic site [active]
857087008684	putative active site [active]
857087008685	putative substrate binding site [chemical binding]; other site
857087008686	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
857087008687	putative GSH binding site [chemical binding]; other site
857087008688	catalytic residues [active]
857087008689	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
857087008690	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
857087008691	Lipopolysaccharide-assembly; Region: LptE; cl01125
857087008692	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
857087008693	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
857087008694	HIGH motif; other site
857087008695	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
857087008696	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
857087008697	active site
857087008698	KMSKS motif; other site
857087008699	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
857087008700	tRNA binding surface [nucleotide binding]; other site
857087008701	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
857087008702	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
857087008703	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087008704	P-loop; other site
857087008705	Magnesium ion binding site [ion binding]; other site
857087008706	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087008707	Magnesium ion binding site [ion binding]; other site
857087008708	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
857087008709	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
857087008710	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
857087008711	putative active site [active]
857087008712	catalytic triad [active]
857087008713	putative dimer interface [polypeptide binding]; other site
857087008714	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
857087008715	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
857087008716	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
857087008717	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087008718	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
857087008719	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
857087008720	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087008721	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087008722	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087008723	phosphoenolpyruvate synthase; Validated; Region: PRK06464
857087008724	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
857087008725	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
857087008726	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
857087008727	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
857087008728	catalytic motif [active]
857087008729	Catalytic residue [active]
857087008730	IKI3 family; Region: IKI3; pfam04762
857087008731	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
857087008732	PilZ domain; Region: PilZ; pfam07238
857087008733	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
857087008734	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
857087008735	active site
857087008736	catalytic tetrad [active]
857087008737	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
857087008738	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
857087008739	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
857087008740	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
857087008741	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
857087008742	Protein of unknown function, DUF269; Region: DUF269; pfam03270
857087008743	Rop-like; Region: Rop-like; cl02247
857087008744	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
857087008745	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
857087008746	dimer interface [polypeptide binding]; other site
857087008747	[2Fe-2S] cluster binding site [ion binding]; other site
857087008748	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
857087008749	Uncharacterized conserved protein [Function unknown]; Region: COG2014
857087008750	Domain of unknown function (DUF364); Region: DUF364; pfam04016
857087008751	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
857087008752	Cysteine-rich domain; Region: CCG; pfam02754
857087008753	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
857087008754	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087008755	DNA binding site [nucleotide binding]
857087008756	PAS fold; Region: PAS_4; pfam08448
857087008757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008758	PAS domain; Region: PAS_9; pfam13426
857087008759	putative active site [active]
857087008760	heme pocket [chemical binding]; other site
857087008761	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008762	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008763	metal binding site [ion binding]; metal-binding site
857087008764	active site
857087008765	I-site; other site
857087008766	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087008767	MASE1; Region: MASE1; pfam05231
857087008768	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
857087008769	PAS domain S-box; Region: sensory_box; TIGR00229
857087008770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008771	putative active site [active]
857087008772	heme pocket [chemical binding]; other site
857087008773	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087008774	PAS domain; Region: PAS_9; pfam13426
857087008775	putative active site [active]
857087008776	heme pocket [chemical binding]; other site
857087008777	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087008778	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087008779	metal binding site [ion binding]; metal-binding site
857087008780	active site
857087008781	I-site; other site
857087008782	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087008783	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
857087008784	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
857087008785	iron-sulfur cluster [ion binding]; other site
857087008786	[2Fe-2S] cluster binding site [ion binding]; other site
857087008787	flavodoxin FldA; Validated; Region: PRK09267
857087008788	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
857087008789	putative GSH binding site [chemical binding]; other site
857087008790	catalytic residues [active]
857087008791	BolA-like protein; Region: BolA; cl00386
857087008792	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
857087008793	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
857087008794	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
857087008795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087008796	Walker A motif; other site
857087008797	ATP binding site [chemical binding]; other site
857087008798	Walker B motif; other site
857087008799	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
857087008800	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
857087008801	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
857087008802	NifZ domain; Region: NifZ; pfam04319
857087008803	Nitrogen fixation protein NifW; Region: NifW; pfam03206
857087008804	serine O-acetyltransferase; Region: cysE; TIGR01172
857087008805	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
857087008806	trimer interface [polypeptide binding]; other site
857087008807	active site
857087008808	substrate binding site [chemical binding]; other site
857087008809	CoA binding site [chemical binding]; other site
857087008810	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
857087008811	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
857087008812	active site
857087008813	catalytic residues [active]
857087008814	metal binding site [ion binding]; metal-binding site
857087008815	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
857087008816	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
857087008817	putative active site [active]
857087008818	dihydropteroate synthase-related protein; Region: TIGR00284
857087008819	Protein of unknown function (DUF512); Region: DUF512; pfam04459
857087008820	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
857087008821	substrate binding pocket [chemical binding]; other site
857087008822	dimer interface [polypeptide binding]; other site
857087008823	inhibitor binding site; inhibition site
857087008824	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
857087008825	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
857087008826	FAD binding site [chemical binding]; other site
857087008827	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
857087008828	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
857087008829	Potassium binding sites [ion binding]; other site
857087008830	Cesium cation binding sites [ion binding]; other site
857087008831	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
857087008832	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
857087008833	THF binding site; other site
857087008834	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
857087008835	substrate binding site [chemical binding]; other site
857087008836	THF binding site; other site
857087008837	zinc-binding site [ion binding]; other site
857087008838	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087008839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087008840	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
857087008841	dimerization interface [polypeptide binding]; other site
857087008842	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
857087008843	ATP cone domain; Region: ATP-cone; pfam03477
857087008844	Class I ribonucleotide reductase; Region: RNR_I; cd01679
857087008845	active site
857087008846	dimer interface [polypeptide binding]; other site
857087008847	catalytic residues [active]
857087008848	effector binding site; other site
857087008849	R2 peptide binding site; other site
857087008850	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
857087008851	dimer interface [polypeptide binding]; other site
857087008852	putative radical transfer pathway; other site
857087008853	diiron center [ion binding]; other site
857087008854	tyrosyl radical; other site
857087008855	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
857087008856	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
857087008857	Autotransporter beta-domain; Region: Autotransporter; smart00869
857087008858	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
857087008859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
857087008860	DNA-binding site [nucleotide binding]; DNA binding site
857087008861	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087008862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087008863	homodimer interface [polypeptide binding]; other site
857087008864	catalytic residue [active]
857087008865	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
857087008866	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
857087008867	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
857087008868	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087008869	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
857087008870	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
857087008871	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
857087008872	dimerization interface [polypeptide binding]; other site
857087008873	putative ATP binding site [chemical binding]; other site
857087008874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087008875	Coenzyme A binding pocket [chemical binding]; other site
857087008876	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
857087008877	Predicted amidohydrolase [General function prediction only]; Region: COG0388
857087008878	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
857087008879	putative active site [active]
857087008880	catalytic triad [active]
857087008881	putative dimer interface [polypeptide binding]; other site
857087008882	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
857087008883	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
857087008884	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
857087008885	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087008886	catalytic residue [active]
857087008887	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
857087008888	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
857087008889	trimerization site [polypeptide binding]; other site
857087008890	active site
857087008891	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
857087008892	NifU-like domain; Region: NifU; pfam01106
857087008893	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
857087008894	NifZ domain; Region: NifZ; pfam04319
857087008895	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
857087008896	NADPH bind site [chemical binding]; other site
857087008897	putative FMN binding site [chemical binding]; other site
857087008898	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
857087008899	putative FMN binding site [chemical binding]; other site
857087008900	NADPH bind site [chemical binding]; other site
857087008901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
857087008902	Protein of unknown function (DUF330); Region: DUF330; pfam03886
857087008903	mce related protein; Region: MCE; pfam02470
857087008904	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
857087008905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087008906	Walker A/P-loop; other site
857087008907	ATP binding site [chemical binding]; other site
857087008908	Q-loop/lid; other site
857087008909	ABC transporter signature motif; other site
857087008910	Walker B; other site
857087008911	D-loop; other site
857087008912	H-loop/switch region; other site
857087008913	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
857087008914	Permease; Region: Permease; pfam02405
857087008915	hypothetical protein; Provisional; Region: PRK05170
857087008916	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
857087008917	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
857087008918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087008919	Walker A/P-loop; other site
857087008920	ATP binding site [chemical binding]; other site
857087008921	Q-loop/lid; other site
857087008922	ABC transporter signature motif; other site
857087008923	Walker B; other site
857087008924	D-loop; other site
857087008925	H-loop/switch region; other site
857087008926	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
857087008927	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
857087008928	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
857087008929	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
857087008930	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
857087008931	P loop; other site
857087008932	GTP binding site [chemical binding]; other site
857087008933	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
857087008934	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
857087008935	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
857087008936	Subunit III/VIIa interface [polypeptide binding]; other site
857087008937	Phospholipid binding site [chemical binding]; other site
857087008938	Subunit I/III interface [polypeptide binding]; other site
857087008939	Subunit III/VIb interface [polypeptide binding]; other site
857087008940	Subunit III/VIa interface; other site
857087008941	Subunit III/Vb interface [polypeptide binding]; other site
857087008942	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
857087008943	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
857087008944	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
857087008945	Subunit I/III interface [polypeptide binding]; other site
857087008946	D-pathway; other site
857087008947	Subunit I/VIIc interface [polypeptide binding]; other site
857087008948	Subunit I/IV interface [polypeptide binding]; other site
857087008949	Subunit I/II interface [polypeptide binding]; other site
857087008950	Low-spin heme (heme a) binding site [chemical binding]; other site
857087008951	Subunit I/VIIa interface [polypeptide binding]; other site
857087008952	Subunit I/VIa interface [polypeptide binding]; other site
857087008953	Dimer interface; other site
857087008954	Putative water exit pathway; other site
857087008955	Binuclear center (heme a3/CuB) [ion binding]; other site
857087008956	K-pathway; other site
857087008957	Subunit I/Vb interface [polypeptide binding]; other site
857087008958	Putative proton exit pathway; other site
857087008959	Subunit I/VIb interface; other site
857087008960	Subunit I/VIc interface [polypeptide binding]; other site
857087008961	Electron transfer pathway; other site
857087008962	Subunit I/VIIIb interface [polypeptide binding]; other site
857087008963	Subunit I/VIIb interface [polypeptide binding]; other site
857087008964	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
857087008965	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
857087008966	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
857087008967	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087008968	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
857087008969	Hemerythrin; Region: Hemerythrin; cd12107
857087008970	Fe binding site [ion binding]; other site
857087008971	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
857087008972	AAA domain; Region: AAA_26; pfam13500
857087008973	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
857087008974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087008975	S-adenosylmethionine binding site [chemical binding]; other site
857087008976	H-type lectin domain; Region: H_lectin; pfam09458
857087008977	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
857087008978	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
857087008979	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
857087008980	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
857087008981	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087008982	catalytic residue [active]
857087008983	biotin synthase; Region: bioB; TIGR00433
857087008984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087008985	FeS/SAM binding site; other site
857087008986	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
857087008987	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
857087008988	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087008989	active site
857087008990	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
857087008991	ProQ/FINO family; Region: ProQ; pfam04352
857087008992	putative RNA binding sites [nucleotide binding]; other site
857087008993	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
857087008994	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
857087008995	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
857087008996	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087008997	DNA-binding site [nucleotide binding]; DNA binding site
857087008998	RNA-binding motif; other site
857087008999	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
857087009000	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
857087009001	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
857087009002	putative NAD(P) binding site [chemical binding]; other site
857087009003	catalytic Zn binding site [ion binding]; other site
857087009004	structural Zn binding site [ion binding]; other site
857087009005	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
857087009006	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
857087009007	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087009008	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087009009	ligand binding site [chemical binding]; other site
857087009010	flexible hinge region; other site
857087009011	DevC protein; Region: devC; TIGR01185
857087009012	hypothetical protein; Validated; Region: PRK08223
857087009013	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
857087009014	ATP binding site [chemical binding]; other site
857087009015	substrate interface [chemical binding]; other site
857087009016	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
857087009017	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
857087009018	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087009019	Walker A/P-loop; other site
857087009020	ATP binding site [chemical binding]; other site
857087009021	Q-loop/lid; other site
857087009022	ABC transporter signature motif; other site
857087009023	Walker B; other site
857087009024	D-loop; other site
857087009025	H-loop/switch region; other site
857087009026	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
857087009027	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087009028	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
857087009029	Bacterial sugar transferase; Region: Bac_transf; pfam02397
857087009030	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
857087009031	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
857087009032	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
857087009033	active site
857087009034	HIGH motif; other site
857087009035	dimer interface [polypeptide binding]; other site
857087009036	KMSKS motif; other site
857087009037	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
857087009038	active site
857087009039	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
857087009040	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
857087009041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087009042	ATP binding site [chemical binding]; other site
857087009043	putative Mg++ binding site [ion binding]; other site
857087009044	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087009045	nucleotide binding region [chemical binding]; other site
857087009046	ATP-binding site [chemical binding]; other site
857087009047	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
857087009048	HRDC domain; Region: HRDC; pfam00570
857087009049	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
857087009050	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
857087009051	Active Sites [active]
857087009052	Predicted transcriptional regulator [Transcription]; Region: COG2345
857087009053	HTH domain; Region: HTH_11; pfam08279
857087009054	V4R domain; Region: V4R; cl15268
857087009055	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
857087009056	apolar tunnel; other site
857087009057	heme binding site [chemical binding]; other site
857087009058	dimerization interface [polypeptide binding]; other site
857087009059	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
857087009060	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
857087009061	catalytic loop [active]
857087009062	iron binding site [ion binding]; other site
857087009063	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
857087009064	FAD binding pocket [chemical binding]; other site
857087009065	FAD binding motif [chemical binding]; other site
857087009066	phosphate binding motif [ion binding]; other site
857087009067	beta-alpha-beta structure motif; other site
857087009068	NAD binding pocket [chemical binding]; other site
857087009069	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
857087009070	HPP family; Region: HPP; pfam04982
857087009071	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
857087009072	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
857087009073	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
857087009074	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087009075	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087009076	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087009077	recombination protein RecR; Reviewed; Region: recR; PRK00076
857087009078	RecR protein; Region: RecR; pfam02132
857087009079	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
857087009080	putative active site [active]
857087009081	putative metal-binding site [ion binding]; other site
857087009082	tetramer interface [polypeptide binding]; other site
857087009083	hypothetical protein; Validated; Region: PRK00153
857087009084	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
857087009085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009086	Walker A motif; other site
857087009087	ATP binding site [chemical binding]; other site
857087009088	Walker B motif; other site
857087009089	arginine finger; other site
857087009090	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
857087009091	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
857087009092	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
857087009093	tandem repeat interface [polypeptide binding]; other site
857087009094	oligomer interface [polypeptide binding]; other site
857087009095	active site residues [active]
857087009096	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
857087009097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087009098	motif II; other site
857087009099	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
857087009100	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087009101	RNA binding surface [nucleotide binding]; other site
857087009102	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
857087009103	active site
857087009104	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
857087009105	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
857087009106	homodimer interface [polypeptide binding]; other site
857087009107	oligonucleotide binding site [chemical binding]; other site
857087009108	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
857087009109	TrkA-N domain; Region: TrkA_N; pfam02254
857087009110	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
857087009111	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
857087009112	G1 box; other site
857087009113	putative GEF interaction site [polypeptide binding]; other site
857087009114	GTP/Mg2+ binding site [chemical binding]; other site
857087009115	Switch I region; other site
857087009116	G2 box; other site
857087009117	G3 box; other site
857087009118	Switch II region; other site
857087009119	G4 box; other site
857087009120	G5 box; other site
857087009121	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
857087009122	Homeodomain-like domain; Region: HTH_23; pfam13384
857087009123	Winged helix-turn helix; Region: HTH_29; pfam13551
857087009124	Winged helix-turn helix; Region: HTH_33; pfam13592
857087009125	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087009126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
857087009127	AAA domain; Region: AAA_17; pfam13207
857087009128	flavodoxin FldA; Validated; Region: PRK09267
857087009129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087009130	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
857087009131	Coenzyme A binding pocket [chemical binding]; other site
857087009132	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
857087009133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087009134	putative DNA binding site [nucleotide binding]; other site
857087009135	putative Zn2+ binding site [ion binding]; other site
857087009136	allantoate amidohydrolase; Reviewed; Region: PRK09290
857087009137	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
857087009138	active site
857087009139	metal binding site [ion binding]; metal-binding site
857087009140	dimer interface [polypeptide binding]; other site
857087009141	Isochorismatase family; Region: Isochorismatase; pfam00857
857087009142	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
857087009143	catalytic triad [active]
857087009144	conserved cis-peptide bond; other site
857087009145	Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476
857087009146	Na binding site [ion binding]; other site
857087009147	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
857087009148	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
857087009149	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
857087009150	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
857087009151	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087009152	active site
857087009153	dimer interface [polypeptide binding]; other site
857087009154	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087009155	Ligand Binding Site [chemical binding]; other site
857087009156	Molecular Tunnel; other site
857087009157	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
857087009158	putative deacylase active site [active]
857087009159	YcxB-like protein; Region: YcxB; pfam14317
857087009160	Peptidase C13 family; Region: Peptidase_C13; cl02159
857087009161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
857087009162	Transposase; Region: DEDD_Tnp_IS110; pfam01548
857087009163	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
857087009164	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087009165	non-specific DNA binding site [nucleotide binding]; other site
857087009166	salt bridge; other site
857087009167	sequence-specific DNA binding site [nucleotide binding]; other site
857087009168	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
857087009169	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087009170	putative active site [active]
857087009171	putative NTP binding site [chemical binding]; other site
857087009172	putative nucleic acid binding site [nucleotide binding]; other site
857087009173	Predicted amidohydrolase [General function prediction only]; Region: COG0388
857087009174	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
857087009175	putative active site [active]
857087009176	catalytic triad [active]
857087009177	putative dimer interface [polypeptide binding]; other site
857087009178	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
857087009179	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
857087009180	TIR domain; Region: TIR_2; pfam13676
857087009181	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
857087009182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009183	Walker A motif; other site
857087009184	ATP binding site [chemical binding]; other site
857087009185	Walker B motif; other site
857087009186	arginine finger; other site
857087009187	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
857087009188	Protein of unknown function (DUF938); Region: DUF938; pfam06080
857087009189	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
857087009190	active site clefts [active]
857087009191	zinc binding site [ion binding]; other site
857087009192	dimer interface [polypeptide binding]; other site
857087009193	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
857087009194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087009195	NAD(P) binding site [chemical binding]; other site
857087009196	active site
857087009197	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
857087009198	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
857087009199	Ceramidase; Region: Ceramidase; pfam05875
857087009200	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
857087009201	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087009202	FeS/SAM binding site; other site
857087009203	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
857087009204	Flavodoxin domain; Region: Flavodoxin_5; cl17428
857087009205	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
857087009206	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
857087009207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087009208	ATP binding site [chemical binding]; other site
857087009209	putative Mg++ binding site [ion binding]; other site
857087009210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087009211	nucleotide binding region [chemical binding]; other site
857087009212	ATP-binding site [chemical binding]; other site
857087009213	Helicase associated domain (HA2); Region: HA2; pfam04408
857087009214	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
857087009215	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
857087009216	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
857087009217	PAS domain S-box; Region: sensory_box; TIGR00229
857087009218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009219	putative active site [active]
857087009220	heme pocket [chemical binding]; other site
857087009221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009222	PAS domain; Region: PAS_9; pfam13426
857087009223	putative active site [active]
857087009224	heme pocket [chemical binding]; other site
857087009225	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087009226	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087009227	metal binding site [ion binding]; metal-binding site
857087009228	active site
857087009229	I-site; other site
857087009230	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087009231	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
857087009232	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
857087009233	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
857087009234	active site
857087009235	putative catalytic site [active]
857087009236	DNA binding site [nucleotide binding]
857087009237	putative phosphate binding site [ion binding]; other site
857087009238	metal binding site A [ion binding]; metal-binding site
857087009239	AP binding site [nucleotide binding]; other site
857087009240	metal binding site B [ion binding]; metal-binding site
857087009241	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
857087009242	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087009243	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
857087009244	dimerization interface [polypeptide binding]; other site
857087009245	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
857087009246	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
857087009247	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087009248	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
857087009249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087009250	Walker A/P-loop; other site
857087009251	ATP binding site [chemical binding]; other site
857087009252	Q-loop/lid; other site
857087009253	ABC transporter signature motif; other site
857087009254	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
857087009255	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
857087009256	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087009257	Outer membrane efflux protein; Region: OEP; pfam02321
857087009258	Outer membrane efflux protein; Region: OEP; pfam02321
857087009259	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087009260	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087009261	metal binding site [ion binding]; metal-binding site
857087009262	active site
857087009263	I-site; other site
857087009264	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
857087009265	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
857087009266	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087009267	Coenzyme A binding pocket [chemical binding]; other site
857087009268	Predicted amidohydrolase [General function prediction only]; Region: COG0388
857087009269	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
857087009270	putative active site [active]
857087009271	catalytic triad [active]
857087009272	putative dimer interface [polypeptide binding]; other site
857087009273	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087009274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087009275	S-adenosylmethionine binding site [chemical binding]; other site
857087009276	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
857087009277	dimer interface [polypeptide binding]; other site
857087009278	Alkaline phosphatase homologues; Region: alkPPc; smart00098
857087009279	active site
857087009280	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
857087009281	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087009282	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
857087009283	osmolarity response regulator; Provisional; Region: ompR; PRK09468
857087009284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009285	active site
857087009286	phosphorylation site [posttranslational modification]
857087009287	intermolecular recognition site; other site
857087009288	dimerization interface [polypeptide binding]; other site
857087009289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087009290	DNA binding site [nucleotide binding]
857087009291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087009292	dimer interface [polypeptide binding]; other site
857087009293	phosphorylation site [posttranslational modification]
857087009294	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
857087009295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087009296	ATP binding site [chemical binding]; other site
857087009297	Mg2+ binding site [ion binding]; other site
857087009298	G-X-G motif; other site
857087009299	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
857087009300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087009301	Coenzyme A binding pocket [chemical binding]; other site
857087009302	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
857087009303	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
857087009304	catalytic residues [active]
857087009305	FtsH Extracellular; Region: FtsH_ext; pfam06480
857087009306	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
857087009307	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009308	Walker A motif; other site
857087009309	ATP binding site [chemical binding]; other site
857087009310	Walker B motif; other site
857087009311	arginine finger; other site
857087009312	Peptidase family M41; Region: Peptidase_M41; pfam01434
857087009313	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
857087009314	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
857087009315	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
857087009316	dimer interface [polypeptide binding]; other site
857087009317	putative anticodon binding site; other site
857087009318	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
857087009319	motif 1; other site
857087009320	active site
857087009321	motif 2; other site
857087009322	motif 3; other site
857087009323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
857087009324	Uncharacterized conserved protein [Function unknown]; Region: COG2442
857087009325	peptide chain release factor 2; Validated; Region: prfB; PRK00578
857087009326	This domain is found in peptide chain release factors; Region: PCRF; smart00937
857087009327	RF-1 domain; Region: RF-1; pfam00472
857087009328	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
857087009329	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
857087009330	Protein of unknown function DUF262; Region: DUF262; pfam03235
857087009331	Uncharacterized conserved protein [Function unknown]; Region: COG1479
857087009332	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
857087009333	Immunoglobulin domain; Region: Ig; cl11960
857087009334	triosephosphate isomerase; Provisional; Region: PRK14567
857087009335	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
857087009336	substrate binding site [chemical binding]; other site
857087009337	dimer interface [polypeptide binding]; other site
857087009338	catalytic triad [active]
857087009339	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
857087009340	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
857087009341	active site
857087009342	substrate binding site [chemical binding]; other site
857087009343	metal binding site [ion binding]; metal-binding site
857087009344	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
857087009345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009346	Walker A motif; other site
857087009347	ATP binding site [chemical binding]; other site
857087009348	Walker B motif; other site
857087009349	arginine finger; other site
857087009350	Peptidase family M41; Region: Peptidase_M41; pfam01434
857087009351	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
857087009352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087009353	S-adenosylmethionine binding site [chemical binding]; other site
857087009354	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
857087009355	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
857087009356	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
857087009357	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
857087009358	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
857087009359	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
857087009360	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
857087009361	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
857087009362	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
857087009363	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087009364	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
857087009365	IMP binding site; other site
857087009366	dimer interface [polypeptide binding]; other site
857087009367	interdomain contacts; other site
857087009368	partial ornithine binding site; other site
857087009369	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
857087009370	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
857087009371	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
857087009372	catalytic site [active]
857087009373	subunit interface [polypeptide binding]; other site
857087009374	dihydrodipicolinate reductase; Provisional; Region: PRK00048
857087009375	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
857087009376	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
857087009377	chaperone protein DnaJ; Provisional; Region: PRK10767
857087009378	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087009379	HSP70 interaction site [polypeptide binding]; other site
857087009380	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
857087009381	substrate binding site [polypeptide binding]; other site
857087009382	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
857087009383	Zn binding sites [ion binding]; other site
857087009384	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
857087009385	dimer interface [polypeptide binding]; other site
857087009386	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
857087009387	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
857087009388	nucleotide binding site [chemical binding]; other site
857087009389	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
857087009390	dimer interface [polypeptide binding]; other site
857087009391	GrpE; Region: GrpE; pfam01025
857087009392	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
857087009393	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
857087009394	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
857087009395	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
857087009396	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
857087009397	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087009398	catalytic residue [active]
857087009399	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
857087009400	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
857087009401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009402	Walker A motif; other site
857087009403	ATP binding site [chemical binding]; other site
857087009404	Walker B motif; other site
857087009405	arginine finger; other site
857087009406	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
857087009407	hypothetical protein; Reviewed; Region: PRK09588
857087009408	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
857087009409	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
857087009410	putative active site [active]
857087009411	adenylation catalytic residue [active]
857087009412	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
857087009413	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
857087009414	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
857087009415	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
857087009416	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
857087009417	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
857087009418	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
857087009419	metal-binding site [ion binding]
857087009420	Family description; Region: DsbD_2; pfam13386
857087009421	multicopper oxidase; Provisional; Region: PRK10965
857087009422	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
857087009423	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
857087009424	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
857087009425	Predicted membrane protein [Function unknown]; Region: COG3223
857087009426	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
857087009427	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
857087009428	O-Antigen ligase; Region: Wzy_C; pfam04932
857087009429	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
857087009430	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
857087009431	ArsC family; Region: ArsC; pfam03960
857087009432	putative catalytic residues [active]
857087009433	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
857087009434	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
857087009435	metal binding site [ion binding]; metal-binding site
857087009436	dimer interface [polypeptide binding]; other site
857087009437	hypothetical protein; Reviewed; Region: PRK00024
857087009438	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
857087009439	MPN+ (JAMM) motif; other site
857087009440	Zinc-binding site [ion binding]; other site
857087009441	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
857087009442	Flavoprotein; Region: Flavoprotein; pfam02441
857087009443	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
857087009444	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
857087009445	trimer interface [polypeptide binding]; other site
857087009446	active site
857087009447	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
857087009448	active site
857087009449	substrate binding site [chemical binding]; other site
857087009450	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
857087009451	metal binding site [ion binding]; metal-binding site
857087009452	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
857087009453	feedback inhibition sensing region; other site
857087009454	homohexameric interface [polypeptide binding]; other site
857087009455	nucleotide binding site [chemical binding]; other site
857087009456	N-acetyl-L-glutamate binding site [chemical binding]; other site
857087009457	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
857087009458	YGGT family; Region: YGGT; pfam02325
857087009459	YGGT family; Region: YGGT; pfam02325
857087009460	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
857087009461	pyrroline-5-carboxylate reductase; Region: PLN02688
857087009462	integral membrane protein MviN; Region: mviN; TIGR01695
857087009463	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
857087009464	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
857087009465	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
857087009466	Sporulation related domain; Region: SPOR; pfam05036
857087009467	Domain of unknown function DUF59; Region: DUF59; pfam01883
857087009468	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
857087009469	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
857087009470	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
857087009471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
857087009472	putative DNA binding site [nucleotide binding]; other site
857087009473	putative Zn2+ binding site [ion binding]; other site
857087009474	HipA-like N-terminal domain; Region: HipA_N; pfam07805
857087009475	HipA-like C-terminal domain; Region: HipA_C; pfam07804
857087009476	gamma-glutamyl kinase; Provisional; Region: PRK05429
857087009477	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
857087009478	nucleotide binding site [chemical binding]; other site
857087009479	homotetrameric interface [polypeptide binding]; other site
857087009480	putative phosphate binding site [ion binding]; other site
857087009481	putative allosteric binding site; other site
857087009482	PUA domain; Region: PUA; pfam01472
857087009483	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
857087009484	GTP1/OBG; Region: GTP1_OBG; pfam01018
857087009485	Obg GTPase; Region: Obg; cd01898
857087009486	G1 box; other site
857087009487	GTP/Mg2+ binding site [chemical binding]; other site
857087009488	Switch I region; other site
857087009489	G2 box; other site
857087009490	G3 box; other site
857087009491	Switch II region; other site
857087009492	G4 box; other site
857087009493	G5 box; other site
857087009494	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
857087009495	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
857087009496	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
857087009497	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
857087009498	ThiC-associated domain; Region: ThiC-associated; pfam13667
857087009499	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
857087009500	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
857087009501	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
857087009502	active site
857087009503	HIGH motif; other site
857087009504	KMSKS motif; other site
857087009505	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
857087009506	anticodon binding site; other site
857087009507	tRNA binding surface [nucleotide binding]; other site
857087009508	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
857087009509	dimer interface [polypeptide binding]; other site
857087009510	putative tRNA-binding site [nucleotide binding]; other site
857087009511	ferredoxin; Provisional; Region: PRK08764
857087009512	Putative Fe-S cluster; Region: FeS; pfam04060
857087009513	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
857087009514	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
857087009515	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087009516	metal ion-dependent adhesion site (MIDAS); other site
857087009517	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
857087009518	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087009519	active site
857087009520	ATP binding site [chemical binding]; other site
857087009521	substrate binding site [chemical binding]; other site
857087009522	activation loop (A-loop); other site
857087009523	FHA domain; Region: FHA; pfam00498
857087009524	phosphopeptide binding site; other site
857087009525	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
857087009526	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087009527	phosphopeptide binding site; other site
857087009528	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
857087009529	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
857087009530	Walker A/P-loop; other site
857087009531	ATP binding site [chemical binding]; other site
857087009532	Q-loop/lid; other site
857087009533	ABC transporter signature motif; other site
857087009534	Walker B; other site
857087009535	D-loop; other site
857087009536	H-loop/switch region; other site
857087009537	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
857087009538	glucose-6-phosphate isomerase; Provisional; Region: PRK03868
857087009539	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
857087009540	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
857087009541	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
857087009542	PIN domain; Region: PIN_3; cl17397
857087009543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009544	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087009545	Walker A motif; other site
857087009546	ATP binding site [chemical binding]; other site
857087009547	Walker B motif; other site
857087009548	arginine finger; other site
857087009549	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
857087009550	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
857087009551	putative active site [active]
857087009552	putative PHP Thumb interface [polypeptide binding]; other site
857087009553	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
857087009554	generic binding surface I; other site
857087009555	generic binding surface II; other site
857087009556	DNA Polymerase Y-family; Region: PolY_like; cd03468
857087009557	active site
857087009558	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
857087009559	DNA binding site [nucleotide binding]
857087009560	Uncharacterized conserved protein [Function unknown]; Region: COG4544
857087009561	LexA repressor; Validated; Region: PRK00215
857087009562	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
857087009563	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
857087009564	Catalytic site [active]
857087009565	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
857087009566	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
857087009567	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
857087009568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087009569	dimer interface [polypeptide binding]; other site
857087009570	conserved gate region; other site
857087009571	putative PBP binding loops; other site
857087009572	ABC-ATPase subunit interface; other site
857087009573	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
857087009574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087009575	dimer interface [polypeptide binding]; other site
857087009576	conserved gate region; other site
857087009577	putative PBP binding loops; other site
857087009578	ABC-ATPase subunit interface; other site
857087009579	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
857087009580	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
857087009581	Walker A/P-loop; other site
857087009582	ATP binding site [chemical binding]; other site
857087009583	Q-loop/lid; other site
857087009584	ABC transporter signature motif; other site
857087009585	Walker B; other site
857087009586	D-loop; other site
857087009587	H-loop/switch region; other site
857087009588	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
857087009589	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087009590	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087009591	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
857087009592	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
857087009593	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
857087009594	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
857087009595	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
857087009596	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
857087009597	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087009598	TolR protein; Region: tolR; TIGR02801
857087009599	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
857087009600	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
857087009601	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
857087009602	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087009603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087009604	dimer interface [polypeptide binding]; other site
857087009605	phosphorylation site [posttranslational modification]
857087009606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087009607	ATP binding site [chemical binding]; other site
857087009608	Mg2+ binding site [ion binding]; other site
857087009609	G-X-G motif; other site
857087009610	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087009611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009612	active site
857087009613	phosphorylation site [posttranslational modification]
857087009614	intermolecular recognition site; other site
857087009615	dimerization interface [polypeptide binding]; other site
857087009616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087009617	DNA binding residues [nucleotide binding]
857087009618	dimerization interface [polypeptide binding]; other site
857087009619	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
857087009620	Sensory domain found in PocR; Region: PocR; pfam10114
857087009621	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
857087009622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087009623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087009624	dimer interface [polypeptide binding]; other site
857087009625	phosphorylation site [posttranslational modification]
857087009626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087009627	ATP binding site [chemical binding]; other site
857087009628	Mg2+ binding site [ion binding]; other site
857087009629	G-X-G motif; other site
857087009630	Response regulator receiver domain; Region: Response_reg; pfam00072
857087009631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009632	active site
857087009633	phosphorylation site [posttranslational modification]
857087009634	intermolecular recognition site; other site
857087009635	dimerization interface [polypeptide binding]; other site
857087009636	Response regulator receiver domain; Region: Response_reg; pfam00072
857087009637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009638	active site
857087009639	phosphorylation site [posttranslational modification]
857087009640	intermolecular recognition site; other site
857087009641	dimerization interface [polypeptide binding]; other site
857087009642	PAS domain S-box; Region: sensory_box; TIGR00229
857087009643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009644	putative active site [active]
857087009645	heme pocket [chemical binding]; other site
857087009646	PAS fold; Region: PAS_3; pfam08447
857087009647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009648	heme pocket [chemical binding]; other site
857087009649	putative active site [active]
857087009650	PAS fold; Region: PAS_3; pfam08447
857087009651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009652	putative active site [active]
857087009653	heme pocket [chemical binding]; other site
857087009654	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087009655	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087009656	DNA binding residues [nucleotide binding]
857087009657	dimerization interface [polypeptide binding]; other site
857087009658	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087009659	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087009660	dimer interface [polypeptide binding]; other site
857087009661	putative CheW interface [polypeptide binding]; other site
857087009662	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087009663	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087009664	metal binding site [ion binding]; metal-binding site
857087009665	active site
857087009666	I-site; other site
857087009667	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
857087009668	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087009669	N-terminal plug; other site
857087009670	ligand-binding site [chemical binding]; other site
857087009671	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
857087009672	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
857087009673	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
857087009674	IucA / IucC family; Region: IucA_IucC; pfam04183
857087009675	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
857087009676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087009677	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
857087009678	IucA / IucC family; Region: IucA_IucC; pfam04183
857087009679	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
857087009680	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
857087009681	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
857087009682	active site
857087009683	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087009684	dimer interface [polypeptide binding]; other site
857087009685	catalytic residues [active]
857087009686	substrate binding site [chemical binding]; other site
857087009687	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087009688	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087009689	N-terminal plug; other site
857087009690	ligand-binding site [chemical binding]; other site
857087009691	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
857087009692	recombination factor protein RarA; Reviewed; Region: PRK13342
857087009693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087009694	Walker A motif; other site
857087009695	ATP binding site [chemical binding]; other site
857087009696	Walker B motif; other site
857087009697	arginine finger; other site
857087009698	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
857087009699	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
857087009700	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
857087009701	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
857087009702	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
857087009703	Ligand Binding Site [chemical binding]; other site
857087009704	TilS substrate binding domain; Region: TilS; pfam09179
857087009705	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
857087009706	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
857087009707	PAS domain; Region: PAS; smart00091
857087009708	PAS domain; Region: PAS_9; pfam13426
857087009709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087009710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087009711	metal binding site [ion binding]; metal-binding site
857087009712	active site
857087009713	I-site; other site
857087009714	CTP synthetase; Validated; Region: pyrG; PRK05380
857087009715	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
857087009716	Catalytic site [active]
857087009717	active site
857087009718	UTP binding site [chemical binding]; other site
857087009719	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
857087009720	active site
857087009721	putative oxyanion hole; other site
857087009722	catalytic triad [active]
857087009723	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
857087009724	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
857087009725	enolase; Provisional; Region: eno; PRK00077
857087009726	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
857087009727	dimer interface [polypeptide binding]; other site
857087009728	metal binding site [ion binding]; metal-binding site
857087009729	substrate binding pocket [chemical binding]; other site
857087009730	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
857087009731	Septum formation initiator; Region: DivIC; cl17659
857087009732	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
857087009733	substrate binding site; other site
857087009734	dimer interface; other site
857087009735	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
857087009736	homotrimer interaction site [polypeptide binding]; other site
857087009737	zinc binding site [ion binding]; other site
857087009738	CDP-binding sites; other site
857087009739	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
857087009740	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
857087009741	Permutation of conserved domain; other site
857087009742	active site
857087009743	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cd01291
857087009744	active site
857087009745	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
857087009746	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
857087009747	[4Fe-4S] binding site [ion binding]; other site
857087009748	molybdopterin cofactor binding site; other site
857087009749	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
857087009750	molybdopterin cofactor binding site; other site
857087009751	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
857087009752	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
857087009753	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087009754	cyanate hydratase; Validated; Region: PRK02866
857087009755	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
857087009756	oligomer interface [polypeptide binding]; other site
857087009757	active site
857087009758	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
857087009759	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
857087009760	Walker A/P-loop; other site
857087009761	ATP binding site [chemical binding]; other site
857087009762	Q-loop/lid; other site
857087009763	ABC transporter signature motif; other site
857087009764	Walker B; other site
857087009765	D-loop; other site
857087009766	H-loop/switch region; other site
857087009767	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
857087009768	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
857087009769	Walker A/P-loop; other site
857087009770	ATP binding site [chemical binding]; other site
857087009771	Q-loop/lid; other site
857087009772	ABC transporter signature motif; other site
857087009773	Walker B; other site
857087009774	D-loop; other site
857087009775	H-loop/switch region; other site
857087009776	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
857087009777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087009778	dimer interface [polypeptide binding]; other site
857087009779	conserved gate region; other site
857087009780	putative PBP binding loops; other site
857087009781	ABC-ATPase subunit interface; other site
857087009782	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
857087009783	NMT1-like family; Region: NMT1_2; pfam13379
857087009784	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087009785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087009786	putative active site [active]
857087009787	heme pocket [chemical binding]; other site
857087009788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087009789	dimer interface [polypeptide binding]; other site
857087009790	phosphorylation site [posttranslational modification]
857087009791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087009792	ATP binding site [chemical binding]; other site
857087009793	Mg2+ binding site [ion binding]; other site
857087009794	G-X-G motif; other site
857087009795	Response regulator receiver domain; Region: Response_reg; pfam00072
857087009796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009797	active site
857087009798	phosphorylation site [posttranslational modification]
857087009799	intermolecular recognition site; other site
857087009800	dimerization interface [polypeptide binding]; other site
857087009801	Response regulator receiver domain; Region: Response_reg; pfam00072
857087009802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009803	active site
857087009804	phosphorylation site [posttranslational modification]
857087009805	intermolecular recognition site; other site
857087009806	dimerization interface [polypeptide binding]; other site
857087009807	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087009808	putative binding surface; other site
857087009809	active site
857087009810	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
857087009811	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009812	active site
857087009813	phosphorylation site [posttranslational modification]
857087009814	intermolecular recognition site; other site
857087009815	dimerization interface [polypeptide binding]; other site
857087009816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087009817	Zn2+ binding site [ion binding]; other site
857087009818	Mg2+ binding site [ion binding]; other site
857087009819	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087009820	Transposase; Region: HTH_Tnp_1; pfam01527
857087009821	putative transposase OrfB; Reviewed; Region: PHA02517
857087009822	HTH-like domain; Region: HTH_21; pfam13276
857087009823	Integrase core domain; Region: rve; pfam00665
857087009824	Integrase core domain; Region: rve_3; pfam13683
857087009825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087009826	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
857087009827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
857087009828	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
857087009829	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087009830	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087009831	putative active site [active]
857087009832	putative NTP binding site [chemical binding]; other site
857087009833	putative nucleic acid binding site [nucleotide binding]; other site
857087009834	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087009835	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087009836	RHS Repeat; Region: RHS_repeat; pfam05593
857087009837	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087009838	RHS Repeat; Region: RHS_repeat; pfam05593
857087009839	RHS Repeat; Region: RHS_repeat; pfam05593
857087009840	RHS Repeat; Region: RHS_repeat; pfam05593
857087009841	RHS Repeat; Region: RHS_repeat; pfam05593
857087009842	RHS Repeat; Region: RHS_repeat; pfam05593
857087009843	RHS protein; Region: RHS; pfam03527
857087009844	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087009845	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
857087009846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087009847	active site
857087009848	phosphorylation site [posttranslational modification]
857087009849	intermolecular recognition site; other site
857087009850	ANTAR domain; Region: ANTAR; pfam03861
857087009851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087009852	putative substrate translocation pore; other site
857087009853	nitrite reductase subunit NirD; Provisional; Region: PRK14989
857087009854	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087009855	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
857087009856	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
857087009857	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
857087009858	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
857087009859	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
857087009860	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
857087009861	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
857087009862	Cation efflux family; Region: Cation_efflux; pfam01545
857087009863	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
857087009864	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087009865	Protein phosphatase 2C; Region: PP2C; pfam00481
857087009866	active site
857087009867	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
857087009868	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
857087009869	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
857087009870	hypothetical protein; Provisional; Region: PRK07033
857087009871	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
857087009872	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087009873	ligand binding site [chemical binding]; other site
857087009874	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
857087009875	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
857087009876	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
857087009877	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087009878	phosphopeptide binding site; other site
857087009879	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087009880	Sel1-like repeats; Region: SEL1; smart00671
857087009881	Sel1-like repeats; Region: SEL1; smart00671
857087009882	Caspase domain; Region: Peptidase_C14; pfam00656
857087009883	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
857087009884	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
857087009885	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087009886	active site
857087009887	ATP binding site [chemical binding]; other site
857087009888	substrate binding site [chemical binding]; other site
857087009889	activation loop (A-loop); other site
857087009890	Autotransporter beta-domain; Region: Autotransporter; pfam03797
857087009891	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
857087009892	S1 domain; Region: S1_2; pfam13509
857087009893	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
857087009894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087009895	Mg2+ binding site [ion binding]; other site
857087009896	G-X-G motif; other site
857087009897	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
857087009898	anchoring element; other site
857087009899	dimer interface [polypeptide binding]; other site
857087009900	ATP binding site [chemical binding]; other site
857087009901	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
857087009902	active site
857087009903	metal binding site [ion binding]; metal-binding site
857087009904	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
857087009905	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
857087009906	Tse2 immunity protein Tsi2 and similar proteins; Region: Tsi2_like; cd11690
857087009907	dimer interface [polypeptide binding]; other site
857087009908	Nuclease-related domain; Region: NERD; pfam08378
857087009909	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
857087009910	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
857087009911	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
857087009912	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
857087009913	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
857087009914	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
857087009915	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
857087009916	substrate binding pocket [chemical binding]; other site
857087009917	chain length determination region; other site
857087009918	substrate-Mg2+ binding site; other site
857087009919	catalytic residues [active]
857087009920	aspartate-rich region 1; other site
857087009921	active site lid residues [active]
857087009922	aspartate-rich region 2; other site
857087009923	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
857087009924	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
857087009925	TPP-binding site; other site
857087009926	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
857087009927	PYR/PP interface [polypeptide binding]; other site
857087009928	dimer interface [polypeptide binding]; other site
857087009929	TPP binding site [chemical binding]; other site
857087009930	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
857087009931	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087009932	active site
857087009933	VacJ like lipoprotein; Region: VacJ; cl01073
857087009934	hopanoid biosynthesis associated membrane protein HpnM; Region: HpnM; TIGR03481
857087009935	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
857087009936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087009937	FeS/SAM binding site; other site
857087009938	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
857087009939	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
857087009940	active site lid residues [active]
857087009941	substrate binding pocket [chemical binding]; other site
857087009942	catalytic residues [active]
857087009943	substrate-Mg2+ binding site; other site
857087009944	aspartate-rich region 1; other site
857087009945	aspartate-rich region 2; other site
857087009946	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
857087009947	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
857087009948	Active site cavity [active]
857087009949	catalytic acid [active]
857087009950	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
857087009951	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
857087009952	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
857087009953	inhibitor-cofactor binding pocket; inhibition site
857087009954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087009955	catalytic residue [active]
857087009956	CopC domain; Region: CopC; cl01012
857087009957	Copper resistance protein D; Region: CopD; cl00563
857087009958	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
857087009959	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
857087009960	TPP-binding site; other site
857087009961	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
857087009962	PYR/PP interface [polypeptide binding]; other site
857087009963	dimer interface [polypeptide binding]; other site
857087009964	TPP binding site [chemical binding]; other site
857087009965	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
857087009966	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
857087009967	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
857087009968	active site
857087009969	catalytic triad [active]
857087009970	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
857087009971	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
857087009972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087009973	S-adenosylmethionine binding site [chemical binding]; other site
857087009974	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
857087009975	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
857087009976	active site
857087009977	PilZ domain; Region: PilZ; cl01260
857087009978	DNA polymerase III subunit delta'; Validated; Region: PRK05707
857087009979	Thermolysin metallopeptidase, alpha-helical domain; Region: Peptidase_M4_C; pfam02868
857087009980	DNA polymerase III subunit delta'; Validated; Region: PRK08485
857087009981	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
857087009982	thymidylate kinase; Validated; Region: tmk; PRK00698
857087009983	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
857087009984	TMP-binding site; other site
857087009985	ATP-binding site [chemical binding]; other site
857087009986	YceG-like family; Region: YceG; pfam02618
857087009987	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
857087009988	dimerization interface [polypeptide binding]; other site
857087009989	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
857087009990	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
857087009991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087009992	catalytic residue [active]
857087009993	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
857087009994	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
857087009995	dimer interface [polypeptide binding]; other site
857087009996	active site
857087009997	acyl carrier protein; Provisional; Region: acpP; PRK00982
857087009998	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
857087009999	putative active site [active]
857087010000	catalytic site [active]
857087010001	putative metal binding site [ion binding]; other site
857087010002	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
857087010003	ligand binding site [chemical binding]; other site
857087010004	active site
857087010005	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087010006	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087010007	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087010008	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087010009	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
857087010010	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
857087010011	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
857087010012	putative C-terminal domain interface [polypeptide binding]; other site
857087010013	putative GSH binding site (G-site) [chemical binding]; other site
857087010014	putative dimer interface [polypeptide binding]; other site
857087010015	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
857087010016	putative N-terminal domain interface [polypeptide binding]; other site
857087010017	putative dimer interface [polypeptide binding]; other site
857087010018	putative substrate binding pocket (H-site) [chemical binding]; other site
857087010019	Uncharacterized conserved protein [Function unknown]; Region: COG0398
857087010020	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
857087010021	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
857087010022	putative catalytic site [active]
857087010023	putative metal binding site [ion binding]; other site
857087010024	putative phosphate binding site [ion binding]; other site
857087010025	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
857087010026	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
857087010027	active site
857087010028	catalytic residues [active]
857087010029	metal binding site [ion binding]; metal-binding site
857087010030	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
857087010031	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
857087010032	putative active site [active]
857087010033	substrate binding site [chemical binding]; other site
857087010034	putative cosubstrate binding site; other site
857087010035	catalytic site [active]
857087010036	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
857087010037	substrate binding site [chemical binding]; other site
857087010038	16S rRNA methyltransferase B; Provisional; Region: PRK10901
857087010039	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
857087010040	putative RNA binding site [nucleotide binding]; other site
857087010041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087010042	S-adenosylmethionine binding site [chemical binding]; other site
857087010043	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
857087010044	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
857087010045	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087010046	dimerization interface [polypeptide binding]; other site
857087010047	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087010048	dimer interface [polypeptide binding]; other site
857087010049	phosphorylation site [posttranslational modification]
857087010050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010051	ATP binding site [chemical binding]; other site
857087010052	Mg2+ binding site [ion binding]; other site
857087010053	G-X-G motif; other site
857087010054	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087010055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010056	active site
857087010057	phosphorylation site [posttranslational modification]
857087010058	intermolecular recognition site; other site
857087010059	dimerization interface [polypeptide binding]; other site
857087010060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087010061	Walker A motif; other site
857087010062	ATP binding site [chemical binding]; other site
857087010063	Walker B motif; other site
857087010064	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
857087010065	23S rRNA interface [nucleotide binding]; other site
857087010066	L3 interface [polypeptide binding]; other site
857087010067	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
857087010068	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
857087010069	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087010070	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087010071	metal binding site [ion binding]; metal-binding site
857087010072	active site
857087010073	I-site; other site
857087010074	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087010075	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
857087010076	putative catalytic site [active]
857087010077	putative metal binding site [ion binding]; other site
857087010078	putative phosphate binding site [ion binding]; other site
857087010079	acyl-CoA synthetase; Validated; Region: PRK05850
857087010080	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
857087010081	acyl-activating enzyme (AAE) consensus motif; other site
857087010082	active site
857087010083	Condensation domain; Region: Condensation; pfam00668
857087010084	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
857087010085	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
857087010086	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010087	acyl-activating enzyme (AAE) consensus motif; other site
857087010088	AMP binding site [chemical binding]; other site
857087010089	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010090	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
857087010091	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
857087010092	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
857087010093	Condensation domain; Region: Condensation; pfam00668
857087010094	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
857087010095	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
857087010096	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010097	acyl-activating enzyme (AAE) consensus motif; other site
857087010098	AMP binding site [chemical binding]; other site
857087010099	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010100	Condensation domain; Region: Condensation; pfam00668
857087010101	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
857087010102	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
857087010103	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010104	acyl-activating enzyme (AAE) consensus motif; other site
857087010105	AMP binding site [chemical binding]; other site
857087010106	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010107	Condensation domain; Region: Condensation; pfam00668
857087010108	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
857087010109	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
857087010110	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010111	acyl-activating enzyme (AAE) consensus motif; other site
857087010112	AMP binding site [chemical binding]; other site
857087010113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010114	Condensation domain; Region: Condensation; pfam00668
857087010115	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
857087010116	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010117	acyl-activating enzyme (AAE) consensus motif; other site
857087010118	AMP binding site [chemical binding]; other site
857087010119	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010120	Condensation domain; Region: Condensation; pfam00668
857087010121	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
857087010122	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
857087010123	acyl-activating enzyme (AAE) consensus motif; other site
857087010124	AMP binding site [chemical binding]; other site
857087010125	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
857087010126	thioester reductase domain; Region: Thioester-redct; TIGR01746
857087010127	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
857087010128	putative NAD(P) binding site [chemical binding]; other site
857087010129	active site
857087010130	putative substrate binding site [chemical binding]; other site
857087010131	putative transposase OrfB; Reviewed; Region: PHA02517
857087010132	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010133	Integrase core domain; Region: rve; pfam00665
857087010134	Integrase core domain; Region: rve_3; pfam13683
857087010135	Transposase; Region: HTH_Tnp_1; cl17663
857087010136	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087010137	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087010138	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087010139	N-terminal plug; other site
857087010140	ligand-binding site [chemical binding]; other site
857087010141	Winged helix-turn helix; Region: HTH_29; pfam13551
857087010142	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010143	Integrase core domain; Region: rve; pfam00665
857087010144	DDE domain; Region: DDE_Tnp_IS240; pfam13610
857087010145	Integrase core domain; Region: rve_3; pfam13683
857087010146	Transposase; Region: HTH_Tnp_1; cl17663
857087010147	Transposase; Region: HTH_Tnp_1; cl17663
857087010148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087010149	HTH domain; Region: HTH_11; cl17392
857087010150	Integrase core domain; Region: rve; pfam00665
857087010151	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
857087010152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087010153	Walker A motif; other site
857087010154	ATP binding site [chemical binding]; other site
857087010155	Walker B motif; other site
857087010156	arginine finger; other site
857087010157	MbtH-like protein; Region: MbtH; cl01279
857087010158	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
857087010159	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087010160	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087010161	DNA binding residues [nucleotide binding]
857087010162	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
857087010163	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087010164	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
857087010165	Walker A/P-loop; other site
857087010166	ATP binding site [chemical binding]; other site
857087010167	Q-loop/lid; other site
857087010168	ABC transporter signature motif; other site
857087010169	Walker B; other site
857087010170	D-loop; other site
857087010171	H-loop/switch region; other site
857087010172	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
857087010173	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
857087010174	active site
857087010175	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087010176	FecR protein; Region: FecR; pfam04773
857087010177	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087010178	FecR protein; Region: FecR; pfam04773
857087010179	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
857087010180	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087010181	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087010182	DNA binding residues [nucleotide binding]
857087010183	Hemerythrin; Region: Hemerythrin; cd12107
857087010184	Fe binding site [ion binding]; other site
857087010185	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
857087010186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010187	active site
857087010188	phosphorylation site [posttranslational modification]
857087010189	intermolecular recognition site; other site
857087010190	dimerization interface [polypeptide binding]; other site
857087010191	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
857087010192	PLD-like domain; Region: PLDc_2; pfam13091
857087010193	putative active site [active]
857087010194	catalytic site [active]
857087010195	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
857087010196	PLD-like domain; Region: PLDc_2; pfam13091
857087010197	putative active site [active]
857087010198	catalytic site [active]
857087010199	Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370
857087010200	Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370
857087010201	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
857087010202	putative catalytic site [active]
857087010203	putative metal binding site [ion binding]; other site
857087010204	putative phosphate binding site [ion binding]; other site
857087010205	Uncharacterized conserved protein [Function unknown]; Region: COG1543
857087010206	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
857087010207	active site
857087010208	substrate binding site [chemical binding]; other site
857087010209	catalytic site [active]
857087010210	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
857087010211	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
857087010212	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
857087010213	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
857087010214	active site
857087010215	catalytic site [active]
857087010216	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
857087010217	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
857087010218	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
857087010219	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
857087010220	FMN-binding pocket [chemical binding]; other site
857087010221	flavin binding motif; other site
857087010222	phosphate binding motif [ion binding]; other site
857087010223	beta-alpha-beta structure motif; other site
857087010224	NAD binding pocket [chemical binding]; other site
857087010225	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
857087010226	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
857087010227	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087010228	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087010229	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
857087010230	putative effector binding pocket; other site
857087010231	putative dimerization interface [polypeptide binding]; other site
857087010232	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087010233	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087010234	putative active site [active]
857087010235	putative NTP binding site [chemical binding]; other site
857087010236	putative nucleic acid binding site [nucleotide binding]; other site
857087010237	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087010238	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
857087010239	DEAD-like helicases superfamily; Region: DEXDc; smart00487
857087010240	ATP binding site [chemical binding]; other site
857087010241	Mg++ binding site [ion binding]; other site
857087010242	motif III; other site
857087010243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087010244	nucleotide binding region [chemical binding]; other site
857087010245	ATP-binding site [chemical binding]; other site
857087010246	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
857087010247	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
857087010248	ATP binding site [chemical binding]; other site
857087010249	hypothetical protein; Provisional; Region: PRK12378
857087010250	Protein of unknown function, DUF547; Region: DUF547; pfam04784
857087010251	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
857087010252	putative hydrophobic ligand binding site [chemical binding]; other site
857087010253	protein interface [polypeptide binding]; other site
857087010254	Uncharacterized conserved protein [Function unknown]; Region: COG0398
857087010255	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
857087010256	mercuric reductase; Validated; Region: PRK06370
857087010257	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087010258	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
857087010259	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
857087010260	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
857087010261	Probable Catalytic site; other site
857087010262	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
857087010263	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
857087010264	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
857087010265	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
857087010266	putative catalytic residues [active]
857087010267	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
857087010268	active site 1 [active]
857087010269	dimer interface [polypeptide binding]; other site
857087010270	hexamer interface [polypeptide binding]; other site
857087010271	active site 2 [active]
857087010272	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
857087010273	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
857087010274	Cupin; Region: Cupin_6; pfam12852
857087010275	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
857087010276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
857087010277	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
857087010278	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087010279	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010280	active site
857087010281	phosphorylation site [posttranslational modification]
857087010282	intermolecular recognition site; other site
857087010283	dimerization interface [polypeptide binding]; other site
857087010284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087010285	Walker A motif; other site
857087010286	ATP binding site [chemical binding]; other site
857087010287	Walker B motif; other site
857087010288	arginine finger; other site
857087010289	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087010290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087010291	dimer interface [polypeptide binding]; other site
857087010292	phosphorylation site [posttranslational modification]
857087010293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010294	ATP binding site [chemical binding]; other site
857087010295	G-X-G motif; other site
857087010296	Cupin domain; Region: Cupin_2; pfam07883
857087010297	Low affinity iron permease; Region: Iron_permease; pfam04120
857087010298	Uncharacterized conserved protein [Function unknown]; Region: COG0398
857087010299	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
857087010300	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
857087010301	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
857087010302	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
857087010303	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
857087010304	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
857087010305	YfdX protein; Region: YfdX; pfam10938
857087010306	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
857087010307	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
857087010308	Cl- selectivity filter; other site
857087010309	Cl- binding residues [ion binding]; other site
857087010310	pore gating glutamate residue; other site
857087010311	dimer interface [polypeptide binding]; other site
857087010312	H+/Cl- coupling transport residue; other site
857087010313	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
857087010314	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087010315	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087010316	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087010317	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
857087010318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
857087010319	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
857087010320	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
857087010321	Walker A/P-loop; other site
857087010322	ATP binding site [chemical binding]; other site
857087010323	Q-loop/lid; other site
857087010324	ABC transporter signature motif; other site
857087010325	Walker B; other site
857087010326	D-loop; other site
857087010327	H-loop/switch region; other site
857087010328	ABC-2 type transporter; Region: ABC2_membrane; cl17235
857087010329	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
857087010330	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
857087010331	putative active site [active]
857087010332	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
857087010333	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
857087010334	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087010335	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087010336	putative active site [active]
857087010337	putative NTP binding site [chemical binding]; other site
857087010338	putative nucleic acid binding site [nucleotide binding]; other site
857087010339	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087010340	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
857087010341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087010342	putative substrate translocation pore; other site
857087010343	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
857087010344	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
857087010345	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
857087010346	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
857087010347	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
857087010348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
857087010349	sequence-specific DNA binding site [nucleotide binding]; other site
857087010350	salt bridge; other site
857087010351	Domain of unknown function (DUF955); Region: DUF955; cl01076
857087010352	Homeodomain-like domain; Region: HTH_23; pfam13384
857087010353	Winged helix-turn helix; Region: HTH_29; pfam13551
857087010354	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010355	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087010356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
857087010357	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
857087010358	DNA-binding site [nucleotide binding]; DNA binding site
857087010359	RNA-binding motif; other site
857087010360	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
857087010361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087010362	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
857087010363	Bacterial sugar transferase; Region: Bac_transf; pfam02397
857087010364	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
857087010365	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
857087010366	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087010367	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087010368	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
857087010369	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
857087010370	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
857087010371	sulfotransferase; Region: PLN02164
857087010372	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
857087010373	Phage Tail Collar Domain; Region: Collar; pfam07484
857087010374	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
857087010375	Phage Tail Collar Domain; Region: Collar; pfam07484
857087010376	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
857087010377	Phage Tail Collar Domain; Region: Collar; pfam07484
857087010378	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087010379	dimer interface [polypeptide binding]; other site
857087010380	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
857087010381	active site
857087010382	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087010383	Ligand Binding Site [chemical binding]; other site
857087010384	Molecular Tunnel; other site
857087010385	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087010386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087010387	S-adenosylmethionine binding site [chemical binding]; other site
857087010388	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
857087010389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087010390	Coenzyme A binding pocket [chemical binding]; other site
857087010391	RHS Repeat; Region: RHS_repeat; cl11982
857087010392	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087010393	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087010394	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087010395	RHS Repeat; Region: RHS_repeat; pfam05593
857087010396	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087010397	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087010398	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087010399	RHS Repeat; Region: RHS_repeat; cl11982
857087010400	RHS Repeat; Region: RHS_repeat; cl11982
857087010401	RHS Repeat; Region: RHS_repeat; pfam05593
857087010402	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087010403	RHS Repeat; Region: RHS_repeat; pfam05593
857087010404	exosortase family protein XrtM; Region: exosort_XrtM; TIGR04300
857087010405	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
857087010406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087010407	Walker A/P-loop; other site
857087010408	ATP binding site [chemical binding]; other site
857087010409	Q-loop/lid; other site
857087010410	ABC transporter signature motif; other site
857087010411	Walker B; other site
857087010412	D-loop; other site
857087010413	H-loop/switch region; other site
857087010414	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087010415	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087010416	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087010417	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
857087010418	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087010419	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
857087010420	putative ADP-binding pocket [chemical binding]; other site
857087010421	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
857087010422	active site
857087010423	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
857087010424	homodimer interface [polypeptide binding]; other site
857087010425	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
857087010426	O-Antigen ligase; Region: Wzy_C; pfam04932
857087010427	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
857087010428	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087010429	NAD(P) binding site [chemical binding]; other site
857087010430	active site
857087010431	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087010432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087010433	S-adenosylmethionine binding site [chemical binding]; other site
857087010434	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087010435	active site
857087010436	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
857087010437	dimer interface [polypeptide binding]; other site
857087010438	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087010439	Ligand Binding Site [chemical binding]; other site
857087010440	Molecular Tunnel; other site
857087010441	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087010442	Methyltransferase domain; Region: Methyltransf_11; pfam08241
857087010443	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
857087010444	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
857087010445	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
857087010446	sulfotransferase; Region: PLN02164
857087010447	sulfotransferase; Region: PLN02164
857087010448	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
857087010449	Cupin superfamily protein; Region: Cupin_4; pfam08007
857087010450	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
857087010451	active site
857087010452	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
857087010453	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
857087010454	dimer interface [polypeptide binding]; other site
857087010455	active site
857087010456	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
857087010457	Ligand Binding Site [chemical binding]; other site
857087010458	Molecular Tunnel; other site
857087010459	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
857087010460	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
857087010461	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584
857087010462	putative active site [active]
857087010463	catalytic site [active]
857087010464	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
857087010465	active site
857087010466	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
857087010467	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
857087010468	phosphate binding site [ion binding]; other site
857087010469	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087010470	active site
857087010471	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
857087010472	active site
857087010473	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087010474	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
857087010475	Ligand binding site; other site
857087010476	Putative Catalytic site; other site
857087010477	DXD motif; other site
857087010478	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
857087010479	Homeodomain-like domain; Region: HTH_23; pfam13384
857087010480	Winged helix-turn helix; Region: HTH_29; pfam13551
857087010481	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010482	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087010483	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
857087010484	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
857087010485	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
857087010486	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
857087010487	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
857087010488	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
857087010489	metal ion-dependent adhesion site (MIDAS); other site
857087010490	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
857087010491	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
857087010492	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
857087010493	Walker A motif; other site
857087010494	ATP binding site [chemical binding]; other site
857087010495	Walker B motif; other site
857087010496	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
857087010497	putative transposase OrfB; Reviewed; Region: PHA02517
857087010498	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010499	Integrase core domain; Region: rve; pfam00665
857087010500	Integrase core domain; Region: rve_3; pfam13683
857087010501	Transposase; Region: HTH_Tnp_1; cl17663
857087010502	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087010503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087010504	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
857087010505	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
857087010506	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
857087010507	NAD(P) binding site [chemical binding]; other site
857087010508	catalytic residues [active]
857087010509	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
857087010510	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
857087010511	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
857087010512	conserved cys residue [active]
857087010513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
857087010514	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
857087010515	Fatty acid desaturase; Region: FA_desaturase; pfam00487
857087010516	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
857087010517	carbon storage regulator; Provisional; Region: PRK01712
857087010518	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
857087010519	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
857087010520	GTP/Mg2+ binding site [chemical binding]; other site
857087010521	G4 box; other site
857087010522	G5 box; other site
857087010523	G1 box; other site
857087010524	Switch I region; other site
857087010525	G2 box; other site
857087010526	G3 box; other site
857087010527	Switch II region; other site
857087010528	quinolinate synthetase; Provisional; Region: PRK09375
857087010529	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
857087010530	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
857087010531	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
857087010532	dimer interface [polypeptide binding]; other site
857087010533	anticodon binding site; other site
857087010534	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
857087010535	homodimer interface [polypeptide binding]; other site
857087010536	motif 1; other site
857087010537	active site
857087010538	motif 2; other site
857087010539	GAD domain; Region: GAD; pfam02938
857087010540	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
857087010541	active site
857087010542	motif 3; other site
857087010543	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
857087010544	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
857087010545	active site
857087010546	substrate binding pocket [chemical binding]; other site
857087010547	dimer interface [polypeptide binding]; other site
857087010548	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
857087010549	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
857087010550	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
857087010551	Ligand binding site; other site
857087010552	Putative Catalytic site; other site
857087010553	DXD motif; other site
857087010554	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
857087010555	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
857087010556	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
857087010557	argininosuccinate lyase; Provisional; Region: PRK00855
857087010558	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
857087010559	active sites [active]
857087010560	tetramer interface [polypeptide binding]; other site
857087010561	N-acetylglutamate synthase; Validated; Region: PRK05279
857087010562	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
857087010563	putative feedback inhibition sensing region; other site
857087010564	putative nucleotide binding site [chemical binding]; other site
857087010565	putative substrate binding site [chemical binding]; other site
857087010566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087010567	Coenzyme A binding pocket [chemical binding]; other site
857087010568	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
857087010569	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
857087010570	active site
857087010571	metal binding site [ion binding]; metal-binding site
857087010572	hexamer interface [polypeptide binding]; other site
857087010573	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
857087010574	putative active site [active]
857087010575	Ap4A binding site [chemical binding]; other site
857087010576	nudix motif; other site
857087010577	putative metal binding site [ion binding]; other site
857087010578	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
857087010579	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
857087010580	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
857087010581	CPxP  motif; other site
857087010582	siroheme synthase; Provisional; Region: cysG; PRK10637
857087010583	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
857087010584	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
857087010585	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
857087010586	active site
857087010587	SAM binding site [chemical binding]; other site
857087010588	homodimer interface [polypeptide binding]; other site
857087010589	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087010590	Cytochrome c; Region: Cytochrom_C; cl11414
857087010591	argininosuccinate synthase; Provisional; Region: PRK13820
857087010592	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
857087010593	ANP binding site [chemical binding]; other site
857087010594	Substrate Binding Site II [chemical binding]; other site
857087010595	Substrate Binding Site I [chemical binding]; other site
857087010596	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
857087010597	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
857087010598	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087010599	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
857087010600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010601	active site
857087010602	phosphorylation site [posttranslational modification]
857087010603	intermolecular recognition site; other site
857087010604	dimerization interface [polypeptide binding]; other site
857087010605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087010606	DNA binding site [nucleotide binding]
857087010607	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
857087010608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087010609	dimerization interface [polypeptide binding]; other site
857087010610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087010611	dimer interface [polypeptide binding]; other site
857087010612	phosphorylation site [posttranslational modification]
857087010613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010614	ATP binding site [chemical binding]; other site
857087010615	Mg2+ binding site [ion binding]; other site
857087010616	G-X-G motif; other site
857087010617	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
857087010618	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
857087010619	nucleotide binding site [chemical binding]; other site
857087010620	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
857087010621	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
857087010622	Walker A/P-loop; other site
857087010623	ATP binding site [chemical binding]; other site
857087010624	Q-loop/lid; other site
857087010625	ABC transporter signature motif; other site
857087010626	Walker B; other site
857087010627	D-loop; other site
857087010628	H-loop/switch region; other site
857087010629	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
857087010630	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
857087010631	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
857087010632	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087010633	active site
857087010634	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
857087010635	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087010636	active site
857087010637	ATP binding site [chemical binding]; other site
857087010638	substrate binding site [chemical binding]; other site
857087010639	activation loop (A-loop); other site
857087010640	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
857087010641	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
857087010642	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
857087010643	catalytic site [active]
857087010644	active site
857087010645	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
857087010646	pyruvate kinase; Provisional; Region: PRK05826
857087010647	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
857087010648	domain interfaces; other site
857087010649	active site
857087010650	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
857087010651	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
857087010652	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
857087010653	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087010654	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087010655	N-terminal plug; other site
857087010656	ligand-binding site [chemical binding]; other site
857087010657	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
857087010658	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087010659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087010660	dimerization interface [polypeptide binding]; other site
857087010661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087010662	dimer interface [polypeptide binding]; other site
857087010663	phosphorylation site [posttranslational modification]
857087010664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010665	ATP binding site [chemical binding]; other site
857087010666	Mg2+ binding site [ion binding]; other site
857087010667	G-X-G motif; other site
857087010668	Response regulator receiver domain; Region: Response_reg; pfam00072
857087010669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010670	active site
857087010671	phosphorylation site [posttranslational modification]
857087010672	intermolecular recognition site; other site
857087010673	dimerization interface [polypeptide binding]; other site
857087010674	Response regulator receiver domain; Region: Response_reg; pfam00072
857087010675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010676	active site
857087010677	phosphorylation site [posttranslational modification]
857087010678	intermolecular recognition site; other site
857087010679	dimerization interface [polypeptide binding]; other site
857087010680	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087010681	putative binding surface; other site
857087010682	active site
857087010683	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087010684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010685	active site
857087010686	phosphorylation site [posttranslational modification]
857087010687	intermolecular recognition site; other site
857087010688	dimerization interface [polypeptide binding]; other site
857087010689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087010690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087010691	metal binding site [ion binding]; metal-binding site
857087010692	active site
857087010693	I-site; other site
857087010694	PAS domain; Region: PAS_9; pfam13426
857087010695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010696	putative active site [active]
857087010697	heme pocket [chemical binding]; other site
857087010698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010699	PAS domain; Region: PAS_9; pfam13426
857087010700	putative active site [active]
857087010701	heme pocket [chemical binding]; other site
857087010702	PAS domain S-box; Region: sensory_box; TIGR00229
857087010703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010704	putative active site [active]
857087010705	heme pocket [chemical binding]; other site
857087010706	PAS domain S-box; Region: sensory_box; TIGR00229
857087010707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010708	putative active site [active]
857087010709	heme pocket [chemical binding]; other site
857087010710	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
857087010711	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
857087010712	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
857087010713	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
857087010714	dimer interface [polypeptide binding]; other site
857087010715	PYR/PP interface [polypeptide binding]; other site
857087010716	TPP binding site [chemical binding]; other site
857087010717	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
857087010718	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
857087010719	TPP-binding site [chemical binding]; other site
857087010720	dimer interface [polypeptide binding]; other site
857087010721	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
857087010722	anti sigma factor interaction site; other site
857087010723	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087010724	regulatory phosphorylation site [posttranslational modification]; other site
857087010725	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
857087010726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010727	ATP binding site [chemical binding]; other site
857087010728	Mg2+ binding site [ion binding]; other site
857087010729	G-X-G motif; other site
857087010730	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
857087010731	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087010732	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087010733	N-terminal plug; other site
857087010734	ligand-binding site [chemical binding]; other site
857087010735	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
857087010736	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
857087010737	catalytic site [active]
857087010738	putative active site [active]
857087010739	putative substrate binding site [chemical binding]; other site
857087010740	HRDC domain; Region: HRDC; pfam00570
857087010741	MASE1; Region: MASE1; pfam05231
857087010742	PAS domain S-box; Region: sensory_box; TIGR00229
857087010743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010744	putative active site [active]
857087010745	heme pocket [chemical binding]; other site
857087010746	PAS fold; Region: PAS_4; pfam08448
857087010747	PAS fold; Region: PAS_4; pfam08448
857087010748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010749	PAS domain; Region: PAS_9; pfam13426
857087010750	putative active site [active]
857087010751	heme pocket [chemical binding]; other site
857087010752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087010753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087010754	metal binding site [ion binding]; metal-binding site
857087010755	active site
857087010756	I-site; other site
857087010757	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087010758	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
857087010759	Predicted membrane protein [Function unknown]; Region: COG2119
857087010760	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
857087010761	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
857087010762	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
857087010763	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
857087010764	motif 1; other site
857087010765	dimer interface [polypeptide binding]; other site
857087010766	active site
857087010767	motif 2; other site
857087010768	motif 3; other site
857087010769	elongation factor P; Validated; Region: PRK00529
857087010770	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
857087010771	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
857087010772	RNA binding site [nucleotide binding]; other site
857087010773	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
857087010774	RNA binding site [nucleotide binding]; other site
857087010775	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
857087010776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010777	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087010778	putative active site [active]
857087010779	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010780	putative active site [active]
857087010781	heme pocket [chemical binding]; other site
857087010782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010783	PAS fold; Region: PAS_3; pfam08447
857087010784	putative active site [active]
857087010785	heme pocket [chemical binding]; other site
857087010786	PAS fold; Region: PAS_3; pfam08447
857087010787	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087010788	heme pocket [chemical binding]; other site
857087010789	putative active site [active]
857087010790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087010791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087010792	dimer interface [polypeptide binding]; other site
857087010793	phosphorylation site [posttranslational modification]
857087010794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087010795	ATP binding site [chemical binding]; other site
857087010796	Mg2+ binding site [ion binding]; other site
857087010797	G-X-G motif; other site
857087010798	Response regulator receiver domain; Region: Response_reg; pfam00072
857087010799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010800	active site
857087010801	phosphorylation site [posttranslational modification]
857087010802	intermolecular recognition site; other site
857087010803	dimerization interface [polypeptide binding]; other site
857087010804	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
857087010805	putative binding surface; other site
857087010806	active site
857087010807	Response regulator receiver domain; Region: Response_reg; pfam00072
857087010808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087010809	active site
857087010810	phosphorylation site [posttranslational modification]
857087010811	intermolecular recognition site; other site
857087010812	dimerization interface [polypeptide binding]; other site
857087010813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087010814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087010815	metal binding site [ion binding]; metal-binding site
857087010816	active site
857087010817	I-site; other site
857087010818	Family description; Region: DsbD_2; pfam13386
857087010819	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
857087010820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087010821	Walker A motif; other site
857087010822	ATP binding site [chemical binding]; other site
857087010823	Walker B motif; other site
857087010824	arginine finger; other site
857087010825	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087010826	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087010827	active site
857087010828	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
857087010829	active site
857087010830	hydrophilic channel; other site
857087010831	dimerization interface [polypeptide binding]; other site
857087010832	catalytic residues [active]
857087010833	active site lid [active]
857087010834	Recombination protein O N terminal; Region: RecO_N; pfam11967
857087010835	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
857087010836	Recombination protein O C terminal; Region: RecO_C; pfam02565
857087010837	GTPase Era; Reviewed; Region: era; PRK00089
857087010838	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
857087010839	G1 box; other site
857087010840	GTP/Mg2+ binding site [chemical binding]; other site
857087010841	Switch I region; other site
857087010842	G2 box; other site
857087010843	Switch II region; other site
857087010844	G3 box; other site
857087010845	G4 box; other site
857087010846	G5 box; other site
857087010847	KH domain; Region: KH_2; pfam07650
857087010848	ribonuclease III; Reviewed; Region: rnc; PRK00102
857087010849	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
857087010850	dimerization interface [polypeptide binding]; other site
857087010851	active site
857087010852	metal binding site [ion binding]; metal-binding site
857087010853	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
857087010854	dsRNA binding site [nucleotide binding]; other site
857087010855	signal peptidase I; Provisional; Region: PRK10861
857087010856	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
857087010857	Catalytic site [active]
857087010858	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
857087010859	GTP-binding protein LepA; Provisional; Region: PRK05433
857087010860	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
857087010861	G1 box; other site
857087010862	putative GEF interaction site [polypeptide binding]; other site
857087010863	GTP/Mg2+ binding site [chemical binding]; other site
857087010864	Switch I region; other site
857087010865	G2 box; other site
857087010866	G3 box; other site
857087010867	Switch II region; other site
857087010868	G4 box; other site
857087010869	G5 box; other site
857087010870	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
857087010871	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
857087010872	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
857087010873	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
857087010874	FtsZ protein binding site [polypeptide binding]; other site
857087010875	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
857087010876	AAA domain; Region: AAA_23; pfam13476
857087010877	Walker A/P-loop; other site
857087010878	ATP binding site [chemical binding]; other site
857087010879	Q-loop/lid; other site
857087010880	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
857087010881	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
857087010882	Q-loop/lid; other site
857087010883	ABC transporter signature motif; other site
857087010884	Walker B; other site
857087010885	D-loop; other site
857087010886	H-loop/switch region; other site
857087010887	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
857087010888	active site
857087010889	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
857087010890	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
857087010891	Protein of unknown function, DUF393; Region: DUF393; pfam04134
857087010892	phytoene desaturase; Region: crtI_fam; TIGR02734
857087010893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087010894	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
857087010895	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
857087010896	NAD(P) binding site [chemical binding]; other site
857087010897	catalytic residues [active]
857087010898	phytoene desaturase; Region: crtI_fam; TIGR02734
857087010899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
857087010900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
857087010901	Transposase; Region: HTH_Tnp_1; pfam01527
857087010902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087010903	Integrase core domain; Region: rve; pfam00665
857087010904	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
857087010905	active site
857087010906	catalytic triad [active]
857087010907	oxyanion hole [active]
857087010908	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
857087010909	Homeodomain-like domain; Region: HTH_32; pfam13565
857087010910	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
857087010911	Integrase core domain; Region: rve; pfam00665
857087010912	Integrase core domain; Region: rve_3; pfam13683
857087010913	Transposase; Region: HTH_Tnp_1; cl17663
857087010914	Transposase; Region: HTH_Tnp_1; cl17663
857087010915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
857087010916	HTH domain; Region: HTH_11; cl17392
857087010917	Integrase core domain; Region: rve; pfam00665
857087010918	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
857087010919	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
857087010920	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
857087010921	alphaNTD homodimer interface [polypeptide binding]; other site
857087010922	alphaNTD - beta interaction site [polypeptide binding]; other site
857087010923	alphaNTD - beta' interaction site [polypeptide binding]; other site
857087010924	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
857087010925	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
857087010926	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
857087010927	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087010928	RNA binding surface [nucleotide binding]; other site
857087010929	30S ribosomal protein S11; Validated; Region: PRK05309
857087010930	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
857087010931	30S ribosomal protein S13; Region: bact_S13; TIGR03631
857087010932	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
857087010933	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
857087010934	SecY translocase; Region: SecY; pfam00344
857087010935	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
857087010936	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
857087010937	23S rRNA binding site [nucleotide binding]; other site
857087010938	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
857087010939	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
857087010940	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
857087010941	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
857087010942	5S rRNA interface [nucleotide binding]; other site
857087010943	23S rRNA interface [nucleotide binding]; other site
857087010944	L5 interface [polypeptide binding]; other site
857087010945	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
857087010946	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
857087010947	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
857087010948	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
857087010949	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
857087010950	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
857087010951	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
857087010952	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
857087010953	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
857087010954	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
857087010955	RNA binding site [nucleotide binding]; other site
857087010956	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
857087010957	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
857087010958	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
857087010959	23S rRNA interface [nucleotide binding]; other site
857087010960	putative translocon interaction site; other site
857087010961	signal recognition particle (SRP54) interaction site; other site
857087010962	L23 interface [polypeptide binding]; other site
857087010963	trigger factor interaction site; other site
857087010964	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
857087010965	23S rRNA interface [nucleotide binding]; other site
857087010966	5S rRNA interface [nucleotide binding]; other site
857087010967	putative antibiotic binding site [chemical binding]; other site
857087010968	L25 interface [polypeptide binding]; other site
857087010969	L27 interface [polypeptide binding]; other site
857087010970	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
857087010971	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
857087010972	G-X-X-G motif; other site
857087010973	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
857087010974	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
857087010975	putative translocon binding site; other site
857087010976	protein-rRNA interface [nucleotide binding]; other site
857087010977	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
857087010978	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
857087010979	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
857087010980	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
857087010981	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
857087010982	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
857087010983	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
857087010984	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
857087010985	elongation factor Tu; Reviewed; Region: PRK00049
857087010986	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
857087010987	G1 box; other site
857087010988	GEF interaction site [polypeptide binding]; other site
857087010989	GTP/Mg2+ binding site [chemical binding]; other site
857087010990	Switch I region; other site
857087010991	G2 box; other site
857087010992	G3 box; other site
857087010993	Switch II region; other site
857087010994	G4 box; other site
857087010995	G5 box; other site
857087010996	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
857087010997	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
857087010998	Antibiotic Binding Site [chemical binding]; other site
857087010999	elongation factor G; Reviewed; Region: PRK00007
857087011000	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
857087011001	G1 box; other site
857087011002	putative GEF interaction site [polypeptide binding]; other site
857087011003	GTP/Mg2+ binding site [chemical binding]; other site
857087011004	Switch I region; other site
857087011005	G2 box; other site
857087011006	G3 box; other site
857087011007	Switch II region; other site
857087011008	G4 box; other site
857087011009	G5 box; other site
857087011010	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
857087011011	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
857087011012	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
857087011013	30S ribosomal protein S7; Validated; Region: PRK05302
857087011014	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
857087011015	S17 interaction site [polypeptide binding]; other site
857087011016	S8 interaction site; other site
857087011017	16S rRNA interaction site [nucleotide binding]; other site
857087011018	streptomycin interaction site [chemical binding]; other site
857087011019	23S rRNA interaction site [nucleotide binding]; other site
857087011020	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
857087011021	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
857087011022	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
857087011023	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
857087011024	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
857087011025	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
857087011026	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
857087011027	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
857087011028	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
857087011029	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
857087011030	DNA binding site [nucleotide binding]
857087011031	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
857087011032	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
857087011033	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
857087011034	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
857087011035	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
857087011036	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
857087011037	RPB12 interaction site [polypeptide binding]; other site
857087011038	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
857087011039	RPB3 interaction site [polypeptide binding]; other site
857087011040	RPB1 interaction site [polypeptide binding]; other site
857087011041	RPB11 interaction site [polypeptide binding]; other site
857087011042	RPB10 interaction site [polypeptide binding]; other site
857087011043	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
857087011044	peripheral dimer interface [polypeptide binding]; other site
857087011045	core dimer interface [polypeptide binding]; other site
857087011046	L10 interface [polypeptide binding]; other site
857087011047	L11 interface [polypeptide binding]; other site
857087011048	putative EF-Tu interaction site [polypeptide binding]; other site
857087011049	putative EF-G interaction site [polypeptide binding]; other site
857087011050	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
857087011051	23S rRNA interface [nucleotide binding]; other site
857087011052	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
857087011053	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
857087011054	mRNA/rRNA interface [nucleotide binding]; other site
857087011055	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
857087011056	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
857087011057	23S rRNA interface [nucleotide binding]; other site
857087011058	L7/L12 interface [polypeptide binding]; other site
857087011059	putative thiostrepton binding site; other site
857087011060	L25 interface [polypeptide binding]; other site
857087011061	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
857087011062	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
857087011063	putative homodimer interface [polypeptide binding]; other site
857087011064	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
857087011065	heterodimer interface [polypeptide binding]; other site
857087011066	homodimer interface [polypeptide binding]; other site
857087011067	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
857087011068	elongation factor Tu; Reviewed; Region: PRK00049
857087011069	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
857087011070	G1 box; other site
857087011071	GEF interaction site [polypeptide binding]; other site
857087011072	GTP/Mg2+ binding site [chemical binding]; other site
857087011073	Switch I region; other site
857087011074	G2 box; other site
857087011075	G3 box; other site
857087011076	Switch II region; other site
857087011077	G4 box; other site
857087011078	G5 box; other site
857087011079	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
857087011080	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
857087011081	Antibiotic Binding Site [chemical binding]; other site
857087011082	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
857087011083	putative active site [active]
857087011084	catalytic residue [active]
857087011085	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
857087011086	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
857087011087	5S rRNA interface [nucleotide binding]; other site
857087011088	CTC domain interface [polypeptide binding]; other site
857087011089	L16 interface [polypeptide binding]; other site
857087011090	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
857087011091	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
857087011092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087011093	active site
857087011094	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
857087011095	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
857087011096	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
857087011097	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
857087011098	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087011099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011100	TPR motif; other site
857087011101	binding surface
857087011102	Tetratricopeptide repeat; Region: TPR_16; pfam13432
857087011103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011104	binding surface
857087011105	TPR motif; other site
857087011106	Tetratricopeptide repeat; Region: TPR_12; pfam13424
857087011107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011108	binding surface
857087011109	TPR motif; other site
857087011110	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
857087011111	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
857087011112	tRNA; other site
857087011113	putative tRNA binding site [nucleotide binding]; other site
857087011114	putative NADP binding site [chemical binding]; other site
857087011115	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
857087011116	peptide chain release factor 1; Validated; Region: prfA; PRK00591
857087011117	This domain is found in peptide chain release factors; Region: PCRF; smart00937
857087011118	RF-1 domain; Region: RF-1; pfam00472
857087011119	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
857087011120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011121	S-adenosylmethionine binding site [chemical binding]; other site
857087011122	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
857087011123	MPN+ (JAMM) motif; other site
857087011124	Zinc-binding site [ion binding]; other site
857087011125	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
857087011126	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
857087011127	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
857087011128	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
857087011129	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
857087011130	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
857087011131	Sulfate transporter family; Region: Sulfate_transp; pfam00916
857087011132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087011133	dimer interface [polypeptide binding]; other site
857087011134	phosphorylation site [posttranslational modification]
857087011135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011136	ATP binding site [chemical binding]; other site
857087011137	G-X-G motif; other site
857087011138	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
857087011139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011140	active site
857087011141	phosphorylation site [posttranslational modification]
857087011142	intermolecular recognition site; other site
857087011143	dimerization interface [polypeptide binding]; other site
857087011144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087011145	Walker A motif; other site
857087011146	ATP binding site [chemical binding]; other site
857087011147	Walker B motif; other site
857087011148	arginine finger; other site
857087011149	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
857087011150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
857087011151	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
857087011152	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
857087011153	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
857087011154	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
857087011155	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087011156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087011157	non-specific DNA binding site [nucleotide binding]; other site
857087011158	salt bridge; other site
857087011159	sequence-specific DNA binding site [nucleotide binding]; other site
857087011160	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087011161	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087011162	N-terminal plug; other site
857087011163	ligand-binding site [chemical binding]; other site
857087011164	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
857087011165	dimer interface [polypeptide binding]; other site
857087011166	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
857087011167	ligand binding site [chemical binding]; other site
857087011168	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
857087011169	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
857087011170	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
857087011171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087011172	Zn2+ binding site [ion binding]; other site
857087011173	Mg2+ binding site [ion binding]; other site
857087011174	DNA-binding response regulator CreB; Provisional; Region: PRK11083
857087011175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011176	active site
857087011177	phosphorylation site [posttranslational modification]
857087011178	intermolecular recognition site; other site
857087011179	dimerization interface [polypeptide binding]; other site
857087011180	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087011181	DNA binding site [nucleotide binding]
857087011182	sensory histidine kinase CreC; Provisional; Region: PRK11100
857087011183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
857087011184	dimerization interface [polypeptide binding]; other site
857087011185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087011186	dimer interface [polypeptide binding]; other site
857087011187	phosphorylation site [posttranslational modification]
857087011188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011189	ATP binding site [chemical binding]; other site
857087011190	Mg2+ binding site [ion binding]; other site
857087011191	G-X-G motif; other site
857087011192	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
857087011193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
857087011194	MORN repeat; Region: MORN; pfam02493
857087011195	MORN repeat; Region: MORN; cl14787
857087011196	MORN repeat; Region: MORN; cl14787
857087011197	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
857087011198	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087011199	active site
857087011200	ATP binding site [chemical binding]; other site
857087011201	substrate binding site [chemical binding]; other site
857087011202	activation loop (A-loop); other site
857087011203	Uncharacterized conserved protein [Function unknown]; Region: COG1262
857087011204	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
857087011205	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
857087011206	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
857087011207	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
857087011208	metal ion-dependent adhesion site (MIDAS); other site
857087011209	exosortase K; Region: exosort_XrtK; TIGR04287
857087011210	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
857087011211	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
857087011212	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
857087011213	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
857087011214	active site
857087011215	substrate binding site [chemical binding]; other site
857087011216	metal binding site [ion binding]; metal-binding site
857087011217	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
857087011218	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
857087011219	motif 1; other site
857087011220	active site
857087011221	motif 2; other site
857087011222	motif 3; other site
857087011223	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
857087011224	DHHA1 domain; Region: DHHA1; pfam02272
857087011225	Protein of unknown function DUF86; Region: DUF86; cl01031
857087011226	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087011227	active site
857087011228	NTP binding site [chemical binding]; other site
857087011229	metal binding triad [ion binding]; metal-binding site
857087011230	antibiotic binding site [chemical binding]; other site
857087011231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087011232	recombination regulator RecX; Reviewed; Region: recX; PRK00117
857087011233	recombinase A; Provisional; Region: recA; PRK09354
857087011234	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
857087011235	hexamer interface [polypeptide binding]; other site
857087011236	Walker A motif; other site
857087011237	ATP binding site [chemical binding]; other site
857087011238	Walker B motif; other site
857087011239	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
857087011240	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
857087011241	putative hydrophobic ligand binding site [chemical binding]; other site
857087011242	SOUL heme-binding protein; Region: SOUL; pfam04832
857087011243	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
857087011244	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
857087011245	Walker A/P-loop; other site
857087011246	ATP binding site [chemical binding]; other site
857087011247	Q-loop/lid; other site
857087011248	ABC transporter signature motif; other site
857087011249	Walker B; other site
857087011250	D-loop; other site
857087011251	H-loop/switch region; other site
857087011252	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
857087011253	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
857087011254	Walker A/P-loop; other site
857087011255	ATP binding site [chemical binding]; other site
857087011256	Q-loop/lid; other site
857087011257	ABC transporter signature motif; other site
857087011258	Walker B; other site
857087011259	D-loop; other site
857087011260	H-loop/switch region; other site
857087011261	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
857087011262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
857087011263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087011264	dimer interface [polypeptide binding]; other site
857087011265	conserved gate region; other site
857087011266	putative PBP binding loops; other site
857087011267	ABC-ATPase subunit interface; other site
857087011268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
857087011269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087011270	dimer interface [polypeptide binding]; other site
857087011271	conserved gate region; other site
857087011272	putative PBP binding loops; other site
857087011273	ABC-ATPase subunit interface; other site
857087011274	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
857087011275	putative active site [active]
857087011276	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
857087011277	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
857087011278	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
857087011279	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
857087011280	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
857087011281	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
857087011282	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
857087011283	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
857087011284	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087011285	ligand binding site [chemical binding]; other site
857087011286	flexible hinge region; other site
857087011287	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087011288	putative switch regulator; other site
857087011289	non-specific DNA interactions [nucleotide binding]; other site
857087011290	DNA binding site [nucleotide binding]
857087011291	sequence specific DNA binding site [nucleotide binding]; other site
857087011292	putative cAMP binding site [chemical binding]; other site
857087011293	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
857087011294	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087011295	catalytic residues [active]
857087011296	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
857087011297	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
857087011298	acyl-activating enzyme (AAE) consensus motif; other site
857087011299	AMP binding site [chemical binding]; other site
857087011300	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
857087011301	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
857087011302	catalytic triad [active]
857087011303	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087011304	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
857087011305	phosphopeptide binding site; other site
857087011306	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087011307	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087011308	catalytic residue [active]
857087011309	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
857087011310	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
857087011311	active site
857087011312	HIGH motif; other site
857087011313	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
857087011314	active site
857087011315	KMSKS motif; other site
857087011316	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087011317	Sel1-like repeats; Region: SEL1; smart00671
857087011318	Sel1-like repeats; Region: SEL1; smart00671
857087011319	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087011320	metal ion-dependent adhesion site (MIDAS); other site
857087011321	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
857087011322	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087011323	ligand binding site [chemical binding]; other site
857087011324	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
857087011325	Staphylococcal nuclease homologues; Region: SNc; smart00318
857087011326	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
857087011327	Catalytic site; other site
857087011328	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
857087011329	Plant specific mitochondrial import receptor subunit TOM20; Region: TOM20_plant; pfam06552
857087011330	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
857087011331	Cupin domain; Region: Cupin_2; pfam07883
857087011332	CHASE3 domain; Region: CHASE3; pfam05227
857087011333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011334	PAS domain; Region: PAS_9; pfam13426
857087011335	putative active site [active]
857087011336	heme pocket [chemical binding]; other site
857087011337	PAS domain S-box; Region: sensory_box; TIGR00229
857087011338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011339	putative active site [active]
857087011340	heme pocket [chemical binding]; other site
857087011341	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
857087011342	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011343	putative active site [active]
857087011344	heme pocket [chemical binding]; other site
857087011345	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011346	putative active site [active]
857087011347	heme pocket [chemical binding]; other site
857087011348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011349	PAS fold; Region: PAS_3; pfam08447
857087011350	putative active site [active]
857087011351	heme pocket [chemical binding]; other site
857087011352	PAS domain S-box; Region: sensory_box; TIGR00229
857087011353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011354	putative active site [active]
857087011355	heme pocket [chemical binding]; other site
857087011356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011357	PAS fold; Region: PAS_3; pfam08447
857087011358	putative active site [active]
857087011359	heme pocket [chemical binding]; other site
857087011360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087011361	dimer interface [polypeptide binding]; other site
857087011362	phosphorylation site [posttranslational modification]
857087011363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011364	ATP binding site [chemical binding]; other site
857087011365	Mg2+ binding site [ion binding]; other site
857087011366	G-X-G motif; other site
857087011367	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087011368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011369	active site
857087011370	phosphorylation site [posttranslational modification]
857087011371	intermolecular recognition site; other site
857087011372	dimerization interface [polypeptide binding]; other site
857087011373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011374	Response regulator receiver domain; Region: Response_reg; pfam00072
857087011375	active site
857087011376	phosphorylation site [posttranslational modification]
857087011377	intermolecular recognition site; other site
857087011378	dimerization interface [polypeptide binding]; other site
857087011379	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087011380	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087011381	metal binding site [ion binding]; metal-binding site
857087011382	active site
857087011383	I-site; other site
857087011384	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087011385	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
857087011386	DEAD-like helicases superfamily; Region: DEXDc; smart00487
857087011387	ATP binding site [chemical binding]; other site
857087011388	Mg++ binding site [ion binding]; other site
857087011389	motif III; other site
857087011390	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087011391	nucleotide binding region [chemical binding]; other site
857087011392	ATP-binding site [chemical binding]; other site
857087011393	PilZ domain; Region: PilZ; pfam07238
857087011394	ATP-dependent helicase HepA; Validated; Region: PRK04914
857087011395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087011396	ATP binding site [chemical binding]; other site
857087011397	putative Mg++ binding site [ion binding]; other site
857087011398	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087011399	nucleotide binding region [chemical binding]; other site
857087011400	ATP-binding site [chemical binding]; other site
857087011401	VanZ like family; Region: VanZ; pfam04892
857087011402	VanZ like family; Region: VanZ; cl01971
857087011403	O-Antigen ligase; Region: Wzy_C; pfam04932
857087011404	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
857087011405	ligand-binding site [chemical binding]; other site
857087011406	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
857087011407	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
857087011408	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
857087011409	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
857087011410	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
857087011411	active site
857087011412	catalytic residues [active]
857087011413	metal binding site [ion binding]; metal-binding site
857087011414	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
857087011415	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
857087011416	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
857087011417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087011418	catalytic residue [active]
857087011419	Transcriptional regulator; Region: Rrf2; cl17282
857087011420	Rrf2 family protein; Region: rrf2_super; TIGR00738
857087011421	serine O-acetyltransferase; Region: cysE; TIGR01172
857087011422	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
857087011423	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
857087011424	trimer interface [polypeptide binding]; other site
857087011425	active site
857087011426	substrate binding site [chemical binding]; other site
857087011427	CoA binding site [chemical binding]; other site
857087011428	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
857087011429	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
857087011430	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
857087011431	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
857087011432	active site
857087011433	dimerization interface [polypeptide binding]; other site
857087011434	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
857087011435	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
857087011436	NADP binding site [chemical binding]; other site
857087011437	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
857087011438	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
857087011439	NAD(P) binding pocket [chemical binding]; other site
857087011440	response regulator; Provisional; Region: PRK09483
857087011441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011442	active site
857087011443	phosphorylation site [posttranslational modification]
857087011444	intermolecular recognition site; other site
857087011445	dimerization interface [polypeptide binding]; other site
857087011446	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087011447	DNA binding residues [nucleotide binding]
857087011448	dimerization interface [polypeptide binding]; other site
857087011449	prolyl-tRNA synthetase; Provisional; Region: PRK09194
857087011450	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
857087011451	dimer interface [polypeptide binding]; other site
857087011452	motif 1; other site
857087011453	active site
857087011454	motif 2; other site
857087011455	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
857087011456	putative deacylase active site [active]
857087011457	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
857087011458	active site
857087011459	motif 3; other site
857087011460	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
857087011461	anticodon binding site; other site
857087011462	Rubredoxin; Region: Rubredoxin; pfam00301
857087011463	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
857087011464	iron binding site [ion binding]; other site
857087011465	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
857087011466	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
857087011467	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
857087011468	PAAR motif; Region: PAAR_motif; pfam05488
857087011469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011470	TPR motif; other site
857087011471	TPR repeat; Region: TPR_11; pfam13414
857087011472	binding surface
857087011473	TPR repeat; Region: TPR_11; pfam13414
857087011474	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011475	binding surface
857087011476	TPR motif; other site
857087011477	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
857087011478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011479	binding surface
857087011480	TPR motif; other site
857087011481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011482	S-adenosylmethionine binding site [chemical binding]; other site
857087011483	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
857087011484	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
857087011485	oligomer interface [polypeptide binding]; other site
857087011486	metal binding site [ion binding]; metal-binding site
857087011487	metal binding site [ion binding]; metal-binding site
857087011488	putative Cl binding site [ion binding]; other site
857087011489	basic sphincter; other site
857087011490	hydrophobic gate; other site
857087011491	periplasmic entrance; other site
857087011492	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087011493	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
857087011494	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
857087011495	FtsX-like permease family; Region: FtsX; pfam02687
857087011496	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
857087011497	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087011498	Walker A/P-loop; other site
857087011499	ATP binding site [chemical binding]; other site
857087011500	Q-loop/lid; other site
857087011501	ABC transporter signature motif; other site
857087011502	Walker B; other site
857087011503	D-loop; other site
857087011504	H-loop/switch region; other site
857087011505	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
857087011506	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
857087011507	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
857087011508	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
857087011509	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
857087011510	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
857087011511	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
857087011512	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
857087011513	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
857087011514	active site
857087011515	multimer interface [polypeptide binding]; other site
857087011516	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
857087011517	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087011518	FeS/SAM binding site; other site
857087011519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011520	binding surface
857087011521	TPR motif; other site
857087011522	Tetratricopeptide repeat; Region: TPR_12; pfam13424
857087011523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087011524	binding surface
857087011525	TPR motif; other site
857087011526	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
857087011527	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
857087011528	dimer interface [polypeptide binding]; other site
857087011529	motif 1; other site
857087011530	active site
857087011531	motif 2; other site
857087011532	motif 3; other site
857087011533	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
857087011534	anticodon binding site; other site
857087011535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
857087011536	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
857087011537	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
857087011538	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
857087011539	Trp docking motif [polypeptide binding]; other site
857087011540	active site
857087011541	GTP-binding protein Der; Reviewed; Region: PRK00093
857087011542	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
857087011543	G1 box; other site
857087011544	GTP/Mg2+ binding site [chemical binding]; other site
857087011545	Switch I region; other site
857087011546	G2 box; other site
857087011547	Switch II region; other site
857087011548	G3 box; other site
857087011549	G4 box; other site
857087011550	G5 box; other site
857087011551	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
857087011552	G1 box; other site
857087011553	GTP/Mg2+ binding site [chemical binding]; other site
857087011554	Switch I region; other site
857087011555	G2 box; other site
857087011556	G3 box; other site
857087011557	Switch II region; other site
857087011558	G4 box; other site
857087011559	G5 box; other site
857087011560	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
857087011561	dimer interface [polypeptide binding]; other site
857087011562	catalytic triad [active]
857087011563	peroxidatic and resolving cysteines [active]
857087011564	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
857087011565	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
857087011566	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
857087011567	active site
857087011568	HIGH motif; other site
857087011569	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
857087011570	KMSKS motif; other site
857087011571	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
857087011572	tRNA binding surface [nucleotide binding]; other site
857087011573	anticodon binding site; other site
857087011574	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
857087011575	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
857087011576	substrate binding site [chemical binding]; other site
857087011577	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
857087011578	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
857087011579	putative active site [active]
857087011580	putative metal binding site [ion binding]; other site
857087011581	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
857087011582	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
857087011583	methionine sulfoxide reductase B; Provisional; Region: PRK00222
857087011584	SelR domain; Region: SelR; pfam01641
857087011585	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
857087011586	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
857087011587	active site
857087011588	metal binding site [ion binding]; metal-binding site
857087011589	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087011590	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087011591	dimerization interface [polypeptide binding]; other site
857087011592	PAS domain S-box; Region: sensory_box; TIGR00229
857087011593	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011594	putative active site [active]
857087011595	heme pocket [chemical binding]; other site
857087011596	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087011597	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087011598	metal binding site [ion binding]; metal-binding site
857087011599	active site
857087011600	I-site; other site
857087011601	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087011602	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087011603	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087011604	N-terminal plug; other site
857087011605	ligand-binding site [chemical binding]; other site
857087011606	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087011607	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
857087011608	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
857087011609	active site
857087011610	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
857087011611	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
857087011612	active site
857087011613	Int/Topo IB signature motif; other site
857087011614	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
857087011615	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
857087011616	active site
857087011617	DNA binding site [nucleotide binding]
857087011618	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
857087011619	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
857087011620	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
857087011621	RimM N-terminal domain; Region: RimM; pfam01782
857087011622	PRC-barrel domain; Region: PRC; pfam05239
857087011623	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
857087011624	signal recognition particle protein; Provisional; Region: PRK10867
857087011625	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
857087011626	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
857087011627	P loop; other site
857087011628	GTP binding site [chemical binding]; other site
857087011629	Signal peptide binding domain; Region: SRP_SPB; pfam02978
857087011630	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
857087011631	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
857087011632	flagellin; Provisional; Region: PRK12802
857087011633	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
857087011634	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
857087011635	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
857087011636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011637	active site
857087011638	phosphorylation site [posttranslational modification]
857087011639	intermolecular recognition site; other site
857087011640	dimerization interface [polypeptide binding]; other site
857087011641	CheB methylesterase; Region: CheB_methylest; pfam01339
857087011642	CheD chemotactic sensory transduction; Region: CheD; cl00810
857087011643	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
857087011644	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
857087011645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011646	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
857087011647	putative CheA interaction surface; other site
857087011648	PAS domain; Region: PAS_9; pfam13426
857087011649	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
857087011650	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087011651	dimer interface [polypeptide binding]; other site
857087011652	putative CheW interface [polypeptide binding]; other site
857087011653	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
857087011654	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087011655	putative binding surface; other site
857087011656	active site
857087011657	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
857087011658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011659	ATP binding site [chemical binding]; other site
857087011660	Mg2+ binding site [ion binding]; other site
857087011661	G-X-G motif; other site
857087011662	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
857087011663	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
857087011664	anti sigma factor interaction site; other site
857087011665	regulatory phosphorylation site [posttranslational modification]; other site
857087011666	Response regulator receiver domain; Region: Response_reg; pfam00072
857087011667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011668	active site
857087011669	phosphorylation site [posttranslational modification]
857087011670	intermolecular recognition site; other site
857087011671	dimerization interface [polypeptide binding]; other site
857087011672	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087011673	dimer interface [polypeptide binding]; other site
857087011674	putative CheW interface [polypeptide binding]; other site
857087011675	FlaG protein; Region: FlaG; pfam03646
857087011676	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
857087011677	ATP-grasp domain; Region: ATP-grasp_4; cl17255
857087011678	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
857087011679	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
857087011680	catalytic residue [active]
857087011681	flagellar protein FliS; Validated; Region: fliS; PRK05685
857087011682	flagellar capping protein; Reviewed; Region: fliD; PRK08032
857087011683	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
857087011684	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
857087011685	FlaG protein; Region: FlaG; pfam03646
857087011686	flagellin; Provisional; Region: PRK12802
857087011687	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
857087011688	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
857087011689	pseudaminic acid synthase; Region: PseI; TIGR03586
857087011690	NeuB family; Region: NeuB; pfam03102
857087011691	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
857087011692	NeuB binding interface [polypeptide binding]; other site
857087011693	putative substrate binding site [chemical binding]; other site
857087011694	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
857087011695	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
857087011696	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
857087011697	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
857087011698	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087011699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011700	S-adenosylmethionine binding site [chemical binding]; other site
857087011701	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
857087011702	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087011703	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
857087011704	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
857087011705	ligand binding site; other site
857087011706	tetramer interface; other site
857087011707	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
857087011708	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
857087011709	inhibitor-cofactor binding pocket; inhibition site
857087011710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087011711	catalytic residue [active]
857087011712	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
857087011713	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
857087011714	NAD(P) binding site [chemical binding]; other site
857087011715	homodimer interface [polypeptide binding]; other site
857087011716	substrate binding site [chemical binding]; other site
857087011717	active site
857087011718	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
857087011719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
857087011720	Beta-Casp domain; Region: Beta-Casp; smart01027
857087011721	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
857087011722	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
857087011723	Sel1-like repeats; Region: SEL1; smart00671
857087011724	Sel1 repeat; Region: Sel1; pfam08238
857087011725	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
857087011726	nucleotide binding site [chemical binding]; other site
857087011727	putative NEF/HSP70 interaction site [polypeptide binding]; other site
857087011728	SBD interface [polypeptide binding]; other site
857087011729	DNA-K related protein; Region: DUF3731; pfam12531
857087011730	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
857087011731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087011732	FeS/SAM binding site; other site
857087011733	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
857087011734	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
857087011735	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
857087011736	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
857087011737	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
857087011738	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
857087011739	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
857087011740	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
857087011741	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
857087011742	Cytochrome c; Region: Cytochrom_C; cl11414
857087011743	Cytochrome c; Region: Cytochrom_C; cl11414
857087011744	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087011745	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
857087011746	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
857087011747	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
857087011748	Transcriptional regulators [Transcription]; Region: MarR; COG1846
857087011749	MarR family; Region: MarR_2; pfam12802
857087011750	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
857087011751	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
857087011752	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087011753	active site
857087011754	NTP binding site [chemical binding]; other site
857087011755	metal binding triad [ion binding]; metal-binding site
857087011756	antibiotic binding site [chemical binding]; other site
857087011757	Uncharacterized conserved protein [Function unknown]; Region: COG2361
857087011758	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
857087011759	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
857087011760	adenylate kinase; Reviewed; Region: adk; PRK00279
857087011761	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
857087011762	AMP-binding site [chemical binding]; other site
857087011763	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
857087011764	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
857087011765	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
857087011766	substrate binding site [chemical binding]; other site
857087011767	ligand binding site [chemical binding]; other site
857087011768	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
857087011769	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
857087011770	substrate binding site [chemical binding]; other site
857087011771	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
857087011772	tartrate dehydrogenase; Region: TTC; TIGR02089
857087011773	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
857087011774	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
857087011775	FimV N-terminal domain; Region: FimV_core; TIGR03505
857087011776	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
857087011777	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
857087011778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011779	active site
857087011780	phosphorylation site [posttranslational modification]
857087011781	intermolecular recognition site; other site
857087011782	dimerization interface [polypeptide binding]; other site
857087011783	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087011784	Zn2+ binding site [ion binding]; other site
857087011785	Mg2+ binding site [ion binding]; other site
857087011786	NMT1/THI5 like; Region: NMT1; pfam09084
857087011787	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
857087011788	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087011789	substrate binding pocket [chemical binding]; other site
857087011790	membrane-bound complex binding site; other site
857087011791	hinge residues; other site
857087011792	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087011793	substrate binding pocket [chemical binding]; other site
857087011794	membrane-bound complex binding site; other site
857087011795	hinge residues; other site
857087011796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011797	putative active site [active]
857087011798	heme pocket [chemical binding]; other site
857087011799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087011800	dimer interface [polypeptide binding]; other site
857087011801	phosphorylation site [posttranslational modification]
857087011802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011803	ATP binding site [chemical binding]; other site
857087011804	Mg2+ binding site [ion binding]; other site
857087011805	G-X-G motif; other site
857087011806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011807	active site
857087011808	phosphorylation site [posttranslational modification]
857087011809	intermolecular recognition site; other site
857087011810	dimerization interface [polypeptide binding]; other site
857087011811	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
857087011812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087011813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087011814	S-adenosylmethionine binding site [chemical binding]; other site
857087011815	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
857087011816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
857087011817	Smr domain; Region: Smr; pfam01713
857087011818	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
857087011819	putative active site [active]
857087011820	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
857087011821	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
857087011822	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087011823	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087011824	catalytic residue [active]
857087011825	MASE1; Region: MASE1; pfam05231
857087011826	CHASE domain; Region: CHASE; pfam03924
857087011827	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087011828	PAS domain; Region: PAS_9; pfam13426
857087011829	putative active site [active]
857087011830	heme pocket [chemical binding]; other site
857087011831	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087011832	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087011833	metal binding site [ion binding]; metal-binding site
857087011834	active site
857087011835	I-site; other site
857087011836	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087011837	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
857087011838	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
857087011839	hypothetical protein; Provisional; Region: PRK11295
857087011840	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
857087011841	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087011842	FeS/SAM binding site; other site
857087011843	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
857087011844	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087011845	substrate binding pocket [chemical binding]; other site
857087011846	membrane-bound complex binding site; other site
857087011847	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
857087011848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087011849	dimer interface [polypeptide binding]; other site
857087011850	conserved gate region; other site
857087011851	putative PBP binding loops; other site
857087011852	ABC-ATPase subunit interface; other site
857087011853	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
857087011854	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
857087011855	Walker A/P-loop; other site
857087011856	ATP binding site [chemical binding]; other site
857087011857	Q-loop/lid; other site
857087011858	ABC transporter signature motif; other site
857087011859	Walker B; other site
857087011860	D-loop; other site
857087011861	H-loop/switch region; other site
857087011862	Uncharacterized conserved protein [Function unknown]; Region: COG1739
857087011863	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
857087011864	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
857087011865	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
857087011866	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
857087011867	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
857087011868	Walker A/P-loop; other site
857087011869	ATP binding site [chemical binding]; other site
857087011870	Q-loop/lid; other site
857087011871	ABC transporter signature motif; other site
857087011872	Walker B; other site
857087011873	D-loop; other site
857087011874	H-loop/switch region; other site
857087011875	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
857087011876	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
857087011877	putative active site [active]
857087011878	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
857087011879	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
857087011880	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
857087011881	O-Antigen ligase; Region: Wzy_C; pfam04932
857087011882	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087011883	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
857087011884	putative metal binding site; other site
857087011885	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
857087011886	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
857087011887	Substrate binding site; other site
857087011888	metal-binding site
857087011889	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
857087011890	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
857087011891	putative CheA interaction surface; other site
857087011892	CheW-like domain; Region: CheW; pfam01584
857087011893	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
857087011894	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087011895	P-loop; other site
857087011896	Magnesium ion binding site [ion binding]; other site
857087011897	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087011898	Magnesium ion binding site [ion binding]; other site
857087011899	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
857087011900	flagellar motor protein MotD; Reviewed; Region: PRK09038
857087011901	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087011902	ligand binding site [chemical binding]; other site
857087011903	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
857087011904	flagellar motor protein; Reviewed; Region: motC; PRK09109
857087011905	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
857087011906	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
857087011907	putative binding surface; other site
857087011908	active site
857087011909	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
857087011910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087011911	ATP binding site [chemical binding]; other site
857087011912	Mg2+ binding site [ion binding]; other site
857087011913	G-X-G motif; other site
857087011914	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
857087011915	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
857087011916	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
857087011917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087011918	active site
857087011919	phosphorylation site [posttranslational modification]
857087011920	intermolecular recognition site; other site
857087011921	dimerization interface [polypeptide binding]; other site
857087011922	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
857087011923	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087011924	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
857087011925	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087011926	DNA binding residues [nucleotide binding]
857087011927	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
857087011928	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
857087011929	P-loop; other site
857087011930	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
857087011931	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
857087011932	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087011933	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
857087011934	FHIPEP family; Region: FHIPEP; pfam00771
857087011935	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
857087011936	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
857087011937	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
857087011938	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
857087011939	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
857087011940	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
857087011941	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
857087011942	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
857087011943	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
857087011944	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
857087011945	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
857087011946	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
857087011947	active site
857087011948	intersubunit interface [polypeptide binding]; other site
857087011949	zinc binding site [ion binding]; other site
857087011950	Na+ binding site [ion binding]; other site
857087011951	transaldolase-like protein; Provisional; Region: PTZ00411
857087011952	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
857087011953	active site
857087011954	dimer interface [polypeptide binding]; other site
857087011955	catalytic residue [active]
857087011956	transketolase; Reviewed; Region: PRK12753
857087011957	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
857087011958	TPP-binding site [chemical binding]; other site
857087011959	dimer interface [polypeptide binding]; other site
857087011960	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
857087011961	PYR/PP interface [polypeptide binding]; other site
857087011962	dimer interface [polypeptide binding]; other site
857087011963	TPP binding site [chemical binding]; other site
857087011964	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
857087011965	tetramer interface [polypeptide binding]; other site
857087011966	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
857087011967	active site
857087011968	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
857087011969	phosphate binding site [ion binding]; other site
857087011970	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
857087011971	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
857087011972	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087011973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011974	S-adenosylmethionine binding site [chemical binding]; other site
857087011975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087011976	S-adenosylmethionine binding site [chemical binding]; other site
857087011977	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
857087011978	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
857087011979	dimer interface [polypeptide binding]; other site
857087011980	allosteric magnesium binding site [ion binding]; other site
857087011981	active site
857087011982	aspartate-rich active site metal binding site; other site
857087011983	Schiff base residues; other site
857087011984	voltage-gated potassium channel; Provisional; Region: PRK10537
857087011985	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
857087011986	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
857087011987	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
857087011988	shikimate binding site; other site
857087011989	NAD(P) binding site [chemical binding]; other site
857087011990	HDOD domain; Region: HDOD; pfam08668
857087011991	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087011992	ligand binding site [chemical binding]; other site
857087011993	flexible hinge region; other site
857087011994	HDOD domain; Region: HDOD; pfam08668
857087011995	oligopeptidase A; Provisional; Region: PRK10911
857087011996	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
857087011997	active site
857087011998	Zn binding site [ion binding]; other site
857087011999	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
857087012000	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
857087012001	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
857087012002	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
857087012003	trimer interface [polypeptide binding]; other site
857087012004	active site
857087012005	substrate binding site [chemical binding]; other site
857087012006	CoA binding site [chemical binding]; other site
857087012007	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
857087012008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
857087012009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087012010	homodimer interface [polypeptide binding]; other site
857087012011	catalytic residue [active]
857087012012	Peptidase family M48; Region: Peptidase_M48; pfam01435
857087012013	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
857087012014	Protein of unknown function (DUF502); Region: DUF502; cl01107
857087012015	Helix-turn-helix domain; Region: HTH_18; pfam12833
857087012016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
857087012017	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
857087012018	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
857087012019	putative NAD(P) binding site [chemical binding]; other site
857087012020	active site
857087012021	DoxX-like family; Region: DoxX_3; pfam13781
857087012022	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
857087012023	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
857087012024	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
857087012025	iron binding site [ion binding]; other site
857087012026	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
857087012027	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
857087012028	L11 interface [polypeptide binding]; other site
857087012029	putative EF-Tu interaction site [polypeptide binding]; other site
857087012030	putative EF-G interaction site [polypeptide binding]; other site
857087012031	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
857087012032	Proline dehydrogenase; Region: Pro_dh; pfam01619
857087012033	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
857087012034	Glutamate binding site [chemical binding]; other site
857087012035	NAD binding site [chemical binding]; other site
857087012036	catalytic residues [active]
857087012037	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087012038	active site
857087012039	NTP binding site [chemical binding]; other site
857087012040	metal binding triad [ion binding]; metal-binding site
857087012041	antibiotic binding site [chemical binding]; other site
857087012042	Uncharacterized conserved protein [Function unknown]; Region: COG2361
857087012043	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
857087012044	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
857087012045	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
857087012046	TrkA-N domain; Region: TrkA_N; pfam02254
857087012047	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
857087012048	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
857087012049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087012050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087012051	S-adenosylmethionine binding site [chemical binding]; other site
857087012052	Acylphosphatase; Region: Acylphosphatase; pfam00708
857087012053	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
857087012054	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
857087012055	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
857087012056	domain interfaces; other site
857087012057	active site
857087012058	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
857087012059	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
857087012060	active site
857087012061	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
857087012062	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
857087012063	HemY protein N-terminus; Region: HemY_N; pfam07219
857087012064	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
857087012065	binding surface
857087012066	TPR motif; other site
857087012067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012068	binding surface
857087012069	TPR motif; other site
857087012070	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
857087012071	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
857087012072	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
857087012073	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
857087012074	active site
857087012075	(T/H)XGH motif; other site
857087012076	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
857087012077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087012078	S-adenosylmethionine binding site [chemical binding]; other site
857087012079	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
857087012080	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
857087012081	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
857087012082	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
857087012083	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
857087012084	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
857087012085	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
857087012086	UbiA prenyltransferase family; Region: UbiA; pfam01040
857087012087	hypothetical protein; Validated; Region: PRK09071
857087012088	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
857087012089	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
857087012090	PilZ domain; Region: PilZ; pfam07238
857087012091	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087012092	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087012093	catalytic residue [active]
857087012094	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
857087012095	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
857087012096	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
857087012097	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
857087012098	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
857087012099	ligand binding site [chemical binding]; other site
857087012100	FecR protein; Region: FecR; pfam04773
857087012101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012102	active site
857087012103	phosphorylation site [posttranslational modification]
857087012104	intermolecular recognition site; other site
857087012105	dimerization interface [polypeptide binding]; other site
857087012106	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087012107	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
857087012108	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
857087012109	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087012110	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
857087012111	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
857087012112	cyclase homology domain; Region: CHD; cd07302
857087012113	nucleotidyl binding site; other site
857087012114	metal binding site [ion binding]; metal-binding site
857087012115	dimer interface [polypeptide binding]; other site
857087012116	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087012117	dimerization interface [polypeptide binding]; other site
857087012118	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087012119	GAF domain; Region: GAF; pfam01590
857087012120	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012121	PAS domain; Region: PAS_9; pfam13426
857087012122	putative active site [active]
857087012123	heme pocket [chemical binding]; other site
857087012124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087012125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087012126	metal binding site [ion binding]; metal-binding site
857087012127	active site
857087012128	I-site; other site
857087012129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087012130	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
857087012131	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
857087012132	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087012133	membrane-bound complex binding site; other site
857087012134	hinge residues; other site
857087012135	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
857087012136	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
857087012137	dimer interface [polypeptide binding]; other site
857087012138	putative CheW interface [polypeptide binding]; other site
857087012139	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
857087012140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012141	PAS domain; Region: PAS_9; pfam13426
857087012142	putative active site [active]
857087012143	heme pocket [chemical binding]; other site
857087012144	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
857087012145	Ribonuclease P; Region: Ribonuclease_P; cl00457
857087012146	hypothetical protein; Validated; Region: PRK00041
857087012147	membrane protein insertase; Provisional; Region: PRK01318
857087012148	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
857087012149	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
857087012150	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
857087012151	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
857087012152	G4 box; other site
857087012153	GTP/Mg2+ binding site [chemical binding]; other site
857087012154	G5 box; other site
857087012155	trmE is a tRNA modification GTPase; Region: trmE; cd04164
857087012156	G1 box; other site
857087012157	G1 box; other site
857087012158	GTP/Mg2+ binding site [chemical binding]; other site
857087012159	Switch I region; other site
857087012160	Switch I region; other site
857087012161	G2 box; other site
857087012162	G2 box; other site
857087012163	Switch II region; other site
857087012164	G3 box; other site
857087012165	G4 box; other site
857087012166	G5 box; other site
857087012167	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
857087012168	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
857087012169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087012170	non-specific DNA binding site [nucleotide binding]; other site
857087012171	salt bridge; other site
857087012172	sequence-specific DNA binding site [nucleotide binding]; other site
857087012173	Homeodomain-like domain; Region: HTH_23; pfam13384
857087012174	Winged helix-turn helix; Region: HTH_29; pfam13551
857087012175	Homeodomain-like domain; Region: HTH_32; pfam13565
857087012176	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087012177	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
857087012178	dimerization interface [polypeptide binding]; other site
857087012179	putative DNA binding site [nucleotide binding]; other site
857087012180	putative Zn2+ binding site [ion binding]; other site
857087012181	Low molecular weight phosphatase family; Region: LMWPc; cd00115
857087012182	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
857087012183	active site
857087012184	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
857087012185	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
857087012186	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
857087012187	P loop; other site
857087012188	Nucleotide binding site [chemical binding]; other site
857087012189	DTAP/Switch II; other site
857087012190	Switch I; other site
857087012191	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
857087012192	P loop; other site
857087012193	Nucleotide binding site [chemical binding]; other site
857087012194	DTAP/Switch II; other site
857087012195	Switch I; other site
857087012196	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
857087012197	active site
857087012198	metal binding site [ion binding]; metal-binding site
857087012199	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
857087012200	arsenical-resistance protein; Region: acr3; TIGR00832
857087012201	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
857087012202	Cu(I) binding site [ion binding]; other site
857087012203	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
857087012204	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
857087012205	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
857087012206	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
857087012207	Walker A/P-loop; other site
857087012208	ATP binding site [chemical binding]; other site
857087012209	Q-loop/lid; other site
857087012210	ABC transporter signature motif; other site
857087012211	Walker B; other site
857087012212	D-loop; other site
857087012213	H-loop/switch region; other site
857087012214	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
857087012215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087012216	dimer interface [polypeptide binding]; other site
857087012217	conserved gate region; other site
857087012218	putative PBP binding loops; other site
857087012219	ABC-ATPase subunit interface; other site
857087012220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
857087012221	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
857087012222	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
857087012223	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
857087012224	active site residue [active]
857087012225	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
857087012226	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
857087012227	RHS Repeat; Region: RHS_repeat; pfam05593
857087012228	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087012229	RHS Repeat; Region: RHS_repeat; pfam05593
857087012230	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
857087012231	RHS Repeat; Region: RHS_repeat; pfam05593
857087012232	RHS Repeat; Region: RHS_repeat; pfam05593
857087012233	RHS Repeat; Region: RHS_repeat; cl11982
857087012234	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087012235	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
857087012236	FOG: PKD repeat [General function prediction only]; Region: COG3291
857087012237	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
857087012238	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
857087012239	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
857087012240	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
857087012241	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
857087012242	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087012243	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
857087012244	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
857087012245	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
857087012246	acyl-activating enzyme (AAE) consensus motif; other site
857087012247	AMP binding site [chemical binding]; other site
857087012248	active site
857087012249	CoA binding site [chemical binding]; other site
857087012250	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
857087012251	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
857087012252	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
857087012253	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
857087012254	dimer interface [polypeptide binding]; other site
857087012255	active site
857087012256	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
857087012257	active site 2 [active]
857087012258	active site 1 [active]
857087012259	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
857087012260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
857087012261	NAD(P) binding site [chemical binding]; other site
857087012262	active site
857087012263	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
857087012264	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
857087012265	dimer interface [polypeptide binding]; other site
857087012266	active site
857087012267	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
857087012268	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
857087012269	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
857087012270	putative acyl-acceptor binding pocket; other site
857087012271	Phosphopantetheine attachment site; Region: PP-binding; cl09936
857087012272	acyl carrier protein; Provisional; Region: PRK05350
857087012273	Predicted membrane protein [Function unknown]; Region: COG4648
857087012274	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
857087012275	Ligand binding site; other site
857087012276	Putative Catalytic site; other site
857087012277	DXD motif; other site
857087012278	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
857087012279	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
857087012280	putative acyl-acceptor binding pocket; other site
857087012281	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
857087012282	active site
857087012283	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
857087012284	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
857087012285	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087012286	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
857087012287	MPT binding site; other site
857087012288	trimer interface [polypeptide binding]; other site
857087012289	Protein of unknown function (DUF423); Region: DUF423; pfam04241
857087012290	Predicted membrane protein [Function unknown]; Region: COG3431
857087012291	aminopeptidase N; Provisional; Region: pepN; PRK14015
857087012292	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
857087012293	active site
857087012294	Zn binding site [ion binding]; other site
857087012295	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
857087012296	putative active site pocket [active]
857087012297	4-fold oligomerization interface [polypeptide binding]; other site
857087012298	metal binding residues [ion binding]; metal-binding site
857087012299	3-fold/trimer interface [polypeptide binding]; other site
857087012300	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
857087012301	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
857087012302	putative active site [active]
857087012303	oxyanion strand; other site
857087012304	catalytic triad [active]
857087012305	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
857087012306	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
857087012307	catalytic residues [active]
857087012308	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
857087012309	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
857087012310	substrate binding site [chemical binding]; other site
857087012311	glutamase interaction surface [polypeptide binding]; other site
857087012312	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
857087012313	integrase; Provisional; Region: int; PHA02601
857087012314	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
857087012315	active site
857087012316	DNA binding site [nucleotide binding]
857087012317	Int/Topo IB signature motif; other site
857087012318	Zonular occludens toxin (Zot); Region: Zot; cl17485
857087012319	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
857087012320	Helix-turn-helix domain; Region: HTH_17; cl17695
857087012321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087012322	non-specific DNA binding site [nucleotide binding]; other site
857087012323	salt bridge; other site
857087012324	sequence-specific DNA binding site [nucleotide binding]; other site
857087012325	Restriction endonuclease; Region: Mrr_cat; pfam04471
857087012326	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
857087012327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087012328	non-specific DNA binding site [nucleotide binding]; other site
857087012329	salt bridge; other site
857087012330	sequence-specific DNA binding site [nucleotide binding]; other site
857087012331	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
857087012332	HsdM N-terminal domain; Region: HsdM_N; pfam12161
857087012333	Methyltransferase domain; Region: Methyltransf_26; pfam13659
857087012334	Virulence protein [General function prediction only]; Region: COG3943
857087012335	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
857087012336	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
857087012337	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087012338	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
857087012339	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
857087012340	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087012341	active site
857087012342	NTP binding site [chemical binding]; other site
857087012343	metal binding triad [ion binding]; metal-binding site
857087012344	antibiotic binding site [chemical binding]; other site
857087012345	Protein of unknown function DUF86; Region: DUF86; pfam01934
857087012346	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
857087012347	Divergent AAA domain; Region: AAA_4; pfam04326
857087012348	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
857087012349	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
857087012350	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
857087012351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
857087012352	ATP binding site [chemical binding]; other site
857087012353	putative Mg++ binding site [ion binding]; other site
857087012354	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
857087012355	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
857087012356	Bacterial sugar transferase; Region: Bac_transf; pfam02397
857087012357	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
857087012358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012359	binding surface
857087012360	TPR motif; other site
857087012361	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
857087012362	TPR motif; other site
857087012363	binding surface
857087012364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012365	binding surface
857087012366	TPR motif; other site
857087012367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012368	TPR motif; other site
857087012369	binding surface
857087012370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012371	binding surface
857087012372	TPR motif; other site
857087012373	TPR repeat; Region: TPR_11; pfam13414
857087012374	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
857087012375	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
857087012376	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
857087012377	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
857087012378	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
857087012379	TPR repeat; Region: TPR_11; pfam13414
857087012380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012381	binding surface
857087012382	TPR motif; other site
857087012383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012384	binding surface
857087012385	TPR motif; other site
857087012386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012387	binding surface
857087012388	TPR motif; other site
857087012389	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
857087012390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012391	binding surface
857087012392	TPR motif; other site
857087012393	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012394	TPR motif; other site
857087012395	binding surface
857087012396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012397	binding surface
857087012398	TPR motif; other site
857087012399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012400	TPR motif; other site
857087012401	binding surface
857087012402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012403	binding surface
857087012404	TPR motif; other site
857087012405	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
857087012406	putative ADP-binding pocket [chemical binding]; other site
857087012407	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
857087012408	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
857087012409	active site
857087012410	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
857087012411	active site
857087012412	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
857087012413	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
857087012414	Probable Catalytic site; other site
857087012415	metal-binding site
857087012416	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
857087012417	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
857087012418	Methyltransferase domain; Region: Methyltransf_23; pfam13489
857087012419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087012420	S-adenosylmethionine binding site [chemical binding]; other site
857087012421	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
857087012422	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
857087012423	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
857087012424	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
857087012425	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
857087012426	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
857087012427	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
857087012428	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
857087012429	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
857087012430	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
857087012431	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
857087012432	Chain length determinant protein; Region: Wzz; cl15801
857087012433	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
857087012434	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
857087012435	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
857087012436	SLBB domain; Region: SLBB; pfam10531
857087012437	putative phosphoketolase; Provisional; Region: PRK05261
857087012438	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
857087012439	TPP-binding site; other site
857087012440	XFP C-terminal domain; Region: XFP_C; pfam09363
857087012441	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
857087012442	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
857087012443	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
857087012444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087012445	dimer interface [polypeptide binding]; other site
857087012446	phosphorylation site [posttranslational modification]
857087012447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087012448	ATP binding site [chemical binding]; other site
857087012449	Mg2+ binding site [ion binding]; other site
857087012450	G-X-G motif; other site
857087012451	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
857087012452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012453	active site
857087012454	phosphorylation site [posttranslational modification]
857087012455	intermolecular recognition site; other site
857087012456	dimerization interface [polypeptide binding]; other site
857087012457	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
857087012458	DNA binding site [nucleotide binding]
857087012459	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
857087012460	periplasmic folding chaperone; Provisional; Region: PRK10788
857087012461	SurA N-terminal domain; Region: SurA_N_3; cl07813
857087012462	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
857087012463	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
857087012464	IHF dimer interface [polypeptide binding]; other site
857087012465	IHF - DNA interface [nucleotide binding]; other site
857087012466	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
857087012467	Found in ATP-dependent protease La (LON); Region: LON; smart00464
857087012468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087012469	Walker A motif; other site
857087012470	ATP binding site [chemical binding]; other site
857087012471	Walker B motif; other site
857087012472	arginine finger; other site
857087012473	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
857087012474	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
857087012475	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
857087012476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087012477	Walker A motif; other site
857087012478	ATP binding site [chemical binding]; other site
857087012479	Walker B motif; other site
857087012480	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
857087012481	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
857087012482	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
857087012483	oligomer interface [polypeptide binding]; other site
857087012484	active site residues [active]
857087012485	trigger factor; Provisional; Region: tig; PRK01490
857087012486	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
857087012487	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
857087012488	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
857087012489	DNA topoisomerase I; Validated; Region: PRK06599
857087012490	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
857087012491	active site
857087012492	interdomain interaction site; other site
857087012493	putative metal-binding site [ion binding]; other site
857087012494	nucleotide binding site [chemical binding]; other site
857087012495	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
857087012496	domain I; other site
857087012497	DNA binding groove [nucleotide binding]
857087012498	phosphate binding site [ion binding]; other site
857087012499	domain II; other site
857087012500	domain III; other site
857087012501	nucleotide binding site [chemical binding]; other site
857087012502	catalytic site [active]
857087012503	domain IV; other site
857087012504	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
857087012505	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
857087012506	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
857087012507	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
857087012508	Protein of unknown function (DUF494); Region: DUF494; pfam04361
857087012509	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
857087012510	DNA protecting protein DprA; Region: dprA; TIGR00732
857087012511	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
857087012512	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
857087012513	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
857087012514	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
857087012515	NADP binding site [chemical binding]; other site
857087012516	active site
857087012517	putative substrate binding site [chemical binding]; other site
857087012518	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
857087012519	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
857087012520	NADP-binding site; other site
857087012521	homotetramer interface [polypeptide binding]; other site
857087012522	substrate binding site [chemical binding]; other site
857087012523	homodimer interface [polypeptide binding]; other site
857087012524	active site
857087012525	isocitrate dehydrogenase; Validated; Region: PRK08299
857087012526	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
857087012527	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
857087012528	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
857087012529	Walker A motif; other site
857087012530	ATP binding site [chemical binding]; other site
857087012531	Walker B motif; other site
857087012532	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
857087012533	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
857087012534	Walker A motif; other site
857087012535	ATP binding site [chemical binding]; other site
857087012536	Walker B motif; other site
857087012537	Transglycosylase SLT domain; Region: SLT_2; pfam13406
857087012538	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
857087012539	N-acetyl-D-glucosamine binding site [chemical binding]; other site
857087012540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087012541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012542	active site
857087012543	phosphorylation site [posttranslational modification]
857087012544	intermolecular recognition site; other site
857087012545	dimerization interface [polypeptide binding]; other site
857087012546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087012547	DNA binding residues [nucleotide binding]
857087012548	dimerization interface [polypeptide binding]; other site
857087012549	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
857087012550	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
857087012551	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
857087012552	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
857087012553	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
857087012554	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
857087012555	Cu(I) binding site [ion binding]; other site
857087012556	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
857087012557	hypothetical protein; Provisional; Region: PRK05409
857087012558	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
857087012559	Predicted membrane protein [Function unknown]; Region: COG2259
857087012560	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
857087012561	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
857087012562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087012563	FeS/SAM binding site; other site
857087012564	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
857087012565	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
857087012566	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
857087012567	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
857087012568	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087012569	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
857087012570	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
857087012571	nucleoside/Zn binding site; other site
857087012572	dimer interface [polypeptide binding]; other site
857087012573	catalytic motif [active]
857087012574	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
857087012575	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
857087012576	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
857087012577	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087012578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012579	active site
857087012580	phosphorylation site [posttranslational modification]
857087012581	intermolecular recognition site; other site
857087012582	dimerization interface [polypeptide binding]; other site
857087012583	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087012584	DNA binding residues [nucleotide binding]
857087012585	dimerization interface [polypeptide binding]; other site
857087012586	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
857087012587	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
857087012588	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
857087012589	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
857087012590	Secretin and TonB N terminus short domain; Region: STN; smart00965
857087012591	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
857087012592	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
857087012593	N-terminal plug; other site
857087012594	ligand-binding site [chemical binding]; other site
857087012595	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
857087012596	FecR protein; Region: FecR; pfam04773
857087012597	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
857087012598	RNA polymerase sigma factor; Reviewed; Region: PRK12527
857087012599	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
857087012600	DNA binding residues [nucleotide binding]
857087012601	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
857087012602	active site clefts [active]
857087012603	zinc binding site [ion binding]; other site
857087012604	dimer interface [polypeptide binding]; other site
857087012605	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
857087012606	Homeodomain-like domain; Region: HTH_23; pfam13384
857087012607	Winged helix-turn helix; Region: HTH_29; pfam13551
857087012608	Homeodomain-like domain; Region: HTH_32; pfam13565
857087012609	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087012610	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
857087012611	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
857087012612	putative hydrophobic ligand binding site [chemical binding]; other site
857087012613	protein interface [polypeptide binding]; other site
857087012614	gate; other site
857087012615	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
857087012616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012617	active site
857087012618	phosphorylation site [posttranslational modification]
857087012619	intermolecular recognition site; other site
857087012620	dimerization interface [polypeptide binding]; other site
857087012621	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
857087012622	DNA binding residues [nucleotide binding]
857087012623	dimerization interface [polypeptide binding]; other site
857087012624	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
857087012625	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
857087012626	Trp docking motif [polypeptide binding]; other site
857087012627	dimer interface [polypeptide binding]; other site
857087012628	active site
857087012629	small subunit binding site [polypeptide binding]; other site
857087012630	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
857087012631	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
857087012632	substrate binding pocket [chemical binding]; other site
857087012633	membrane-bound complex binding site; other site
857087012634	hinge residues; other site
857087012635	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
857087012636	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
857087012637	MoxR-like ATPases [General function prediction only]; Region: COG0714
857087012638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
857087012639	Walker A motif; other site
857087012640	ATP binding site [chemical binding]; other site
857087012641	Walker B motif; other site
857087012642	arginine finger; other site
857087012643	Protein of unknown function DUF58; Region: DUF58; pfam01882
857087012644	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087012645	metal ion-dependent adhesion site (MIDAS); other site
857087012646	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
857087012647	metal ion-dependent adhesion site (MIDAS); other site
857087012648	hypothetical protein; Provisional; Region: PRK10316
857087012649	YfdX protein; Region: YfdX; pfam10938
857087012650	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
857087012651	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
857087012652	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
857087012653	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
857087012654	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087012655	Walker A/P-loop; other site
857087012656	ATP binding site [chemical binding]; other site
857087012657	Q-loop/lid; other site
857087012658	ABC transporter signature motif; other site
857087012659	Walker B; other site
857087012660	D-loop; other site
857087012661	H-loop/switch region; other site
857087012662	transcription termination factor Rho; Provisional; Region: rho; PRK09376
857087012663	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
857087012664	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
857087012665	RNA binding site [nucleotide binding]; other site
857087012666	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
857087012667	multimer interface [polypeptide binding]; other site
857087012668	Walker A motif; other site
857087012669	ATP binding site [chemical binding]; other site
857087012670	Walker B motif; other site
857087012671	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
857087012672	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
857087012673	catalytic residues [active]
857087012674	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
857087012675	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
857087012676	ATP binding site [chemical binding]; other site
857087012677	Mg++ binding site [ion binding]; other site
857087012678	motif III; other site
857087012679	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
857087012680	nucleotide binding region [chemical binding]; other site
857087012681	ATP-binding site [chemical binding]; other site
857087012682	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
857087012683	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
857087012684	motif II; other site
857087012685	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
857087012686	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
857087012687	dimer interface [polypeptide binding]; other site
857087012688	ADP-ribose binding site [chemical binding]; other site
857087012689	active site
857087012690	nudix motif; other site
857087012691	metal binding site [ion binding]; metal-binding site
857087012692	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
857087012693	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
857087012694	amidase catalytic site [active]
857087012695	substrate binding site [chemical binding]; other site
857087012696	Zn binding residues [ion binding]; other site
857087012697	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
857087012698	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
857087012699	dimerization interface [polypeptide binding]; other site
857087012700	active site
857087012701	peroxidase; Provisional; Region: PRK15000
857087012702	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
857087012703	dimer interface [polypeptide binding]; other site
857087012704	decamer (pentamer of dimers) interface [polypeptide binding]; other site
857087012705	catalytic triad [active]
857087012706	peroxidatic and resolving cysteines [active]
857087012707	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
857087012708	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
857087012709	putative active site [active]
857087012710	putative NTP binding site [chemical binding]; other site
857087012711	putative nucleic acid binding site [nucleotide binding]; other site
857087012712	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
857087012713	AAA domain; Region: AAA_22; pfam13401
857087012714	BRO family, N-terminal domain; Region: Bro-N; pfam02498
857087012715	BRO family, N-terminal domain; Region: Bro-N; pfam02498
857087012716	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
857087012717	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
857087012718	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087012719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087012720	non-specific DNA binding site [nucleotide binding]; other site
857087012721	salt bridge; other site
857087012722	sequence-specific DNA binding site [nucleotide binding]; other site
857087012723	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
857087012724	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087012725	putative Mg++ binding site [ion binding]; other site
857087012726	AAA domain; Region: AAA_25; pfam13481
857087012727	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
857087012728	Walker A motif; other site
857087012729	ATP binding site [chemical binding]; other site
857087012730	Walker B motif; other site
857087012731	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
857087012732	integrase; Provisional; Region: PRK09692
857087012733	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
857087012734	active site
857087012735	Int/Topo IB signature motif; other site
857087012736	hypothetical protein; Provisional; Region: PRK11820
857087012737	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
857087012738	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
857087012739	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
857087012740	Catalytic domain of Protein Kinases; Region: PKc; cd00180
857087012741	active site
857087012742	ATP binding site [chemical binding]; other site
857087012743	substrate binding site [chemical binding]; other site
857087012744	activation loop (A-loop); other site
857087012745	ribonuclease PH; Reviewed; Region: rph; PRK00173
857087012746	Ribonuclease PH; Region: RNase_PH_bact; cd11362
857087012747	hexamer interface [polypeptide binding]; other site
857087012748	active site
857087012749	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
857087012750	active site
857087012751	dimerization interface [polypeptide binding]; other site
857087012752	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
857087012753	Phosphotransferase enzyme family; Region: APH; pfam01636
857087012754	active site
857087012755	substrate binding site [chemical binding]; other site
857087012756	ATP binding site [chemical binding]; other site
857087012757	glucokinase, proteobacterial type; Region: glk; TIGR00749
857087012758	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
857087012759	nucleotide binding site [chemical binding]; other site
857087012760	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
857087012761	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
857087012762	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
857087012763	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
857087012764	trimer interface [polypeptide binding]; other site
857087012765	active site
857087012766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
857087012767	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
857087012768	AAA domain; Region: AAA_33; pfam13671
857087012769	active site
857087012770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087012771	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087012772	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
857087012773	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
857087012774	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087012775	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
857087012776	HlyD family secretion protein; Region: HlyD_3; pfam13437
857087012777	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
857087012778	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
857087012779	Walker A/P-loop; other site
857087012780	ATP binding site [chemical binding]; other site
857087012781	Q-loop/lid; other site
857087012782	ABC transporter signature motif; other site
857087012783	Walker B; other site
857087012784	D-loop; other site
857087012785	H-loop/switch region; other site
857087012786	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
857087012787	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
857087012788	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
857087012789	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
857087012790	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
857087012791	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
857087012792	substrate binding pocket [chemical binding]; other site
857087012793	chain length determination region; other site
857087012794	substrate-Mg2+ binding site; other site
857087012795	catalytic residues [active]
857087012796	aspartate-rich region 1; other site
857087012797	active site lid residues [active]
857087012798	aspartate-rich region 2; other site
857087012799	Methyltransferase domain; Region: Methyltransf_31; pfam13847
857087012800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087012801	S-adenosylmethionine binding site [chemical binding]; other site
857087012802	tocopherol O-methyltransferase; Region: PLN02244
857087012803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087012804	S-adenosylmethionine binding site [chemical binding]; other site
857087012805	MarR family; Region: MarR_2; cl17246
857087012806	Transcriptional regulators [Transcription]; Region: MarR; COG1846
857087012807	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
857087012808	4Fe-4S binding domain; Region: Fer4; pfam00037
857087012809	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
857087012810	SCP-2 sterol transfer family; Region: SCP2; pfam02036
857087012811	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
857087012812	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087012813	phosphopeptide binding site; other site
857087012814	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
857087012815	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
857087012816	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087012817	ligand binding site [chemical binding]; other site
857087012818	flexible hinge region; other site
857087012819	multifunctional aminopeptidase A; Provisional; Region: PRK00913
857087012820	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
857087012821	interface (dimer of trimers) [polypeptide binding]; other site
857087012822	Substrate-binding/catalytic site; other site
857087012823	Zn-binding sites [ion binding]; other site
857087012824	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
857087012825	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
857087012826	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
857087012827	GAF domain; Region: GAF_3; pfam13492
857087012828	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
857087012829	Zn2+ binding site [ion binding]; other site
857087012830	Mg2+ binding site [ion binding]; other site
857087012831	MAPEG family; Region: MAPEG; cl09190
857087012832	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
857087012833	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
857087012834	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
857087012835	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
857087012836	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
857087012837	catalytic site [active]
857087012838	active site
857087012839	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
857087012840	PEP-CTERM motif; Region: VPEP; pfam07589
857087012841	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
857087012842	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
857087012843	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
857087012844	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087012845	RHS Repeat; Region: RHS_repeat; pfam05593
857087012846	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
857087012847	RHS Repeat; Region: RHS_repeat; pfam05593
857087012848	RHS Repeat; Region: RHS_repeat; pfam05593
857087012849	RHS Repeat; Region: RHS_repeat; pfam05593
857087012850	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
857087012851	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
857087012852	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
857087012853	Putative Ig domain; Region: He_PIG; pfam05345
857087012854	exosortase family protein XrtM; Region: exosort_XrtM; TIGR04300
857087012855	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
857087012856	ZIP Zinc transporter; Region: Zip; pfam02535
857087012857	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
857087012858	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
857087012859	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
857087012860	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
857087012861	RNA binding surface [nucleotide binding]; other site
857087012862	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
857087012863	active site
857087012864	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
857087012865	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
857087012866	binding surface
857087012867	TPR motif; other site
857087012868	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
857087012869	putative active site [active]
857087012870	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
857087012871	thymidylate synthase; Reviewed; Region: thyA; PRK01827
857087012872	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
857087012873	dimerization interface [polypeptide binding]; other site
857087012874	active site
857087012875	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
857087012876	GAF domain; Region: GAF; pfam01590
857087012877	PAS domain S-box; Region: sensory_box; TIGR00229
857087012878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012879	putative active site [active]
857087012880	heme pocket [chemical binding]; other site
857087012881	PAS domain S-box; Region: sensory_box; TIGR00229
857087012882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012883	putative active site [active]
857087012884	heme pocket [chemical binding]; other site
857087012885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
857087012886	Histidine kinase; Region: HisKA_2; pfam07568
857087012887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087012888	ATP binding site [chemical binding]; other site
857087012889	Mg2+ binding site [ion binding]; other site
857087012890	G-X-G motif; other site
857087012891	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087012892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087012893	active site
857087012894	phosphorylation site [posttranslational modification]
857087012895	intermolecular recognition site; other site
857087012896	dimerization interface [polypeptide binding]; other site
857087012897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012898	PAS domain; Region: PAS_9; pfam13426
857087012899	putative active site [active]
857087012900	heme pocket [chemical binding]; other site
857087012901	PAS domain S-box; Region: sensory_box; TIGR00229
857087012902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
857087012903	putative active site [active]
857087012904	heme pocket [chemical binding]; other site
857087012905	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087012906	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087012907	metal binding site [ion binding]; metal-binding site
857087012908	active site
857087012909	I-site; other site
857087012910	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
857087012911	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
857087012912	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
857087012913	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
857087012914	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
857087012915	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
857087012916	minor groove reading motif; other site
857087012917	helix-hairpin-helix signature motif; other site
857087012918	substrate binding pocket [chemical binding]; other site
857087012919	active site
857087012920	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
857087012921	hypothetical protein; Provisional; Region: PRK05409
857087012922	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
857087012923	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
857087012924	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
857087012925	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
857087012926	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
857087012927	dimer interface [polypeptide binding]; other site
857087012928	active site
857087012929	metal binding site [ion binding]; metal-binding site
857087012930	glutathione binding site [chemical binding]; other site
857087012931	HemN family oxidoreductase; Provisional; Region: PRK05660
857087012932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
857087012933	FeS/SAM binding site; other site
857087012934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
857087012935	active site
857087012936	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
857087012937	G1 box; other site
857087012938	GTP/Mg2+ binding site [chemical binding]; other site
857087012939	G2 box; other site
857087012940	Switch I region; other site
857087012941	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
857087012942	G3 box; other site
857087012943	Switch II region; other site
857087012944	GTP/Mg2+ binding site [chemical binding]; other site
857087012945	G4 box; other site
857087012946	G5 box; other site
857087012947	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
857087012948	OsmC-like protein; Region: OsmC; cl00767
857087012949	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
857087012950	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
857087012951	ligand binding site [chemical binding]; other site
857087012952	flexible hinge region; other site
857087012953	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
857087012954	putative switch regulator; other site
857087012955	non-specific DNA interactions [nucleotide binding]; other site
857087012956	DNA binding site [nucleotide binding]
857087012957	sequence specific DNA binding site [nucleotide binding]; other site
857087012958	putative cAMP binding site [chemical binding]; other site
857087012959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
857087012960	Major Facilitator Superfamily; Region: MFS_1; pfam07690
857087012961	putative substrate translocation pore; other site
857087012962	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
857087012963	Peptidase family M23; Region: Peptidase_M23; pfam01551
857087012964	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
857087012965	Uncharacterized conserved protein [Function unknown]; Region: COG0397
857087012966	hypothetical protein; Validated; Region: PRK00029
857087012967	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
857087012968	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
857087012969	dimer interface [polypeptide binding]; other site
857087012970	TPP-binding site [chemical binding]; other site
857087012971	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
857087012972	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
857087012973	E3 interaction surface; other site
857087012974	lipoyl attachment site [posttranslational modification]; other site
857087012975	e3 binding domain; Region: E3_binding; pfam02817
857087012976	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
857087012977	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
857087012978	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
857087012979	active site
857087012980	NTP binding site [chemical binding]; other site
857087012981	metal binding triad [ion binding]; metal-binding site
857087012982	antibiotic binding site [chemical binding]; other site
857087012983	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
857087012984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
857087012985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
857087012986	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
857087012987	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
857087012988	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
857087012989	C-terminal domain interface [polypeptide binding]; other site
857087012990	GSH binding site (G-site) [chemical binding]; other site
857087012991	dimer interface [polypeptide binding]; other site
857087012992	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
857087012993	N-terminal domain interface [polypeptide binding]; other site
857087012994	dimer interface [polypeptide binding]; other site
857087012995	substrate binding pocket (H-site) [chemical binding]; other site
857087012996	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
857087012997	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
857087012998	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
857087012999	Protein of unknown function, DUF; Region: DUF411; cl01142
857087013000	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
857087013001	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
857087013002	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
857087013003	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
857087013004	active site
857087013005	substrate (anthranilate) binding pocket [chemical binding]; other site
857087013006	product (indole) binding pocket [chemical binding]; other site
857087013007	ribulose/triose binding site [chemical binding]; other site
857087013008	phosphate binding site [ion binding]; other site
857087013009	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
857087013010	Protein phosphatase 2C; Region: PP2C; pfam00481
857087013011	active site
857087013012	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
857087013013	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
857087013014	phosphopeptide binding site; other site
857087013015	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
857087013016	active site
857087013017	phosphate binding residues; other site
857087013018	catalytic residues [active]
857087013019	TIGR02646 family protein; Region: TIGR02646
857087013020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087013021	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
857087013022	G1 box; other site
857087013023	Walker A/P-loop; other site
857087013024	GTP/Mg2+ binding site [chemical binding]; other site
857087013025	ATP binding site [chemical binding]; other site
857087013026	G2 box; other site
857087013027	G3 box; other site
857087013028	Switch II region; other site
857087013029	AAA domain; Region: AAA_21; pfam13304
857087013030	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087013031	Q-loop/lid; other site
857087013032	ABC transporter signature motif; other site
857087013033	Walker B; other site
857087013034	D-loop; other site
857087013035	H-loop/switch region; other site
857087013036	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
857087013037	HsdM N-terminal domain; Region: HsdM_N; pfam12161
857087013038	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
857087013039	Methyltransferase domain; Region: Methyltransf_26; pfam13659
857087013040	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
857087013041	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
857087013042	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
857087013043	ATP binding site [chemical binding]; other site
857087013044	putative Mg++ binding site [ion binding]; other site
857087013045	FAD binding site [chemical binding]; other site
857087013046	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
857087013047	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
857087013048	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
857087013049	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
857087013050	helix-hairpin-helix signature motif; other site
857087013051	active site
857087013052	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
857087013053	putative FMN binding site [chemical binding]; other site
857087013054	NADPH bind site [chemical binding]; other site
857087013055	Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603
857087013056	Ligand Binding Site [chemical binding]; other site
857087013057	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
857087013058	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
857087013059	ATP binding site [chemical binding]; other site
857087013060	substrate binding site [chemical binding]; other site
857087013061	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
857087013062	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
857087013063	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
857087013064	non-specific DNA binding site [nucleotide binding]; other site
857087013065	salt bridge; other site
857087013066	sequence-specific DNA binding site [nucleotide binding]; other site
857087013067	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
857087013068	FAD binding site [chemical binding]; other site
857087013069	AAA domain; Region: AAA_22; pfam13401
857087013070	Tn7 transposition regulator TnsC; Region: Tn7_TnsC_Int; pfam11426
857087013071	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
857087013072	active site
857087013073	NTP binding site [chemical binding]; other site
857087013074	metal binding triad [ion binding]; metal-binding site
857087013075	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
857087013076	Ligand Binding Site [chemical binding]; other site
857087013077	Integrase core domain; Region: rve; pfam00665
857087013078	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
857087013079	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
857087013080	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
857087013081	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
857087013082	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
857087013083	glutaminase active site [active]
857087013084	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
857087013085	dimer interface [polypeptide binding]; other site
857087013086	active site
857087013087	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
857087013088	dimer interface [polypeptide binding]; other site
857087013089	active site
857087013090	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
857087013091	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
857087013092	Substrate binding site; other site
857087013093	Mg++ binding site; other site
857087013094	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
857087013095	active site
857087013096	substrate binding site [chemical binding]; other site
857087013097	CoA binding site [chemical binding]; other site
857087013098	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
857087013099	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
857087013100	gamma subunit interface [polypeptide binding]; other site
857087013101	epsilon subunit interface [polypeptide binding]; other site
857087013102	LBP interface [polypeptide binding]; other site
857087013103	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
857087013104	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087013105	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
857087013106	alpha subunit interaction interface [polypeptide binding]; other site
857087013107	Walker A motif; other site
857087013108	ATP binding site [chemical binding]; other site
857087013109	Walker B motif; other site
857087013110	inhibitor binding site; inhibition site
857087013111	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
857087013112	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
857087013113	core domain interface [polypeptide binding]; other site
857087013114	delta subunit interface [polypeptide binding]; other site
857087013115	epsilon subunit interface [polypeptide binding]; other site
857087013116	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
857087013117	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
857087013118	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
857087013119	beta subunit interaction interface [polypeptide binding]; other site
857087013120	Walker A motif; other site
857087013121	ATP binding site [chemical binding]; other site
857087013122	Walker B motif; other site
857087013123	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
857087013124	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
857087013125	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
857087013126	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
857087013127	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
857087013128	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
857087013129	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
857087013130	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
857087013131	ATP synthase I chain; Region: ATP_synt_I; cl09170
857087013132	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
857087013133	ParB-like nuclease domain; Region: ParBc; pfam02195
857087013134	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
857087013135	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087013136	P-loop; other site
857087013137	Magnesium ion binding site [ion binding]; other site
857087013138	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
857087013139	Magnesium ion binding site [ion binding]; other site
857087013140	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
857087013141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
857087013142	S-adenosylmethionine binding site [chemical binding]; other site
857087013143	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
857087013144	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
857087013145	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
857087013146	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
857087013147	dimerization interface [polypeptide binding]; other site
857087013148	active site
857087013149	AAA domain; Region: AAA_32; pfam13654
857087013150	ATP-dependent protease Lon; Provisional; Region: PRK13765
857087013151	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
857087013152	MEKHLA domain; Region: MEKHLA; pfam08670
857087013153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
857087013154	putative active site [active]
857087013155	heme pocket [chemical binding]; other site
857087013156	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
857087013157	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
857087013158	Fumarase C-terminus; Region: Fumerase_C; pfam05683
857087013159	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
857087013160	hypothetical protein; Provisional; Region: PRK05208
857087013161	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
857087013162	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
857087013163	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
857087013164	substrate binding pocket [chemical binding]; other site
857087013165	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
857087013166	B12 binding site [chemical binding]; other site
857087013167	cobalt ligand [ion binding]; other site
857087013168	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
857087013169	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
857087013170	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
857087013171	Protein of unknown function, DUF393; Region: DUF393; pfam04134
857087013172	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
857087013173	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
857087013174	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
857087013175	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
857087013176	putative acyl-acceptor binding pocket; other site
857087013177	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
857087013178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
857087013179	active site
857087013180	motif I; other site
857087013181	motif II; other site
857087013182	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
857087013183	tRNA binding surface [nucleotide binding]; other site
857087013184	anticodon binding site; other site
857087013185	DALR anticodon binding domain; Region: DALR_1; pfam05746
857087013186	Predicted ATPases [General function prediction only]; Region: COG1106
857087013187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
857087013188	Walker A/P-loop; other site
857087013189	ATP binding site [chemical binding]; other site
857087013190	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
857087013191	dimer interface [polypeptide binding]; other site
857087013192	motif 1; other site
857087013193	active site
857087013194	motif 2; other site
857087013195	motif 3; other site
857087013196	putative hydrolase; Provisional; Region: PRK10985
857087013197	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
857087013198	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087013199	HSP70 interaction site [polypeptide binding]; other site
857087013200	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
857087013201	substrate binding site [polypeptide binding]; other site
857087013202	dimer interface [polypeptide binding]; other site
857087013203	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
857087013204	transcriptional regulator PhoU; Provisional; Region: PRK11115
857087013205	PhoU domain; Region: PhoU; pfam01895
857087013206	PhoU domain; Region: PhoU; pfam01895
857087013207	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
857087013208	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
857087013209	Walker A/P-loop; other site
857087013210	ATP binding site [chemical binding]; other site
857087013211	Q-loop/lid; other site
857087013212	ABC transporter signature motif; other site
857087013213	Walker B; other site
857087013214	D-loop; other site
857087013215	H-loop/switch region; other site
857087013216	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
857087013217	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
857087013218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087013219	dimer interface [polypeptide binding]; other site
857087013220	conserved gate region; other site
857087013221	putative PBP binding loops; other site
857087013222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
857087013223	ABC-ATPase subunit interface; other site
857087013224	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
857087013225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087013226	conserved gate region; other site
857087013227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
857087013228	ABC-ATPase subunit interface; other site
857087013229	PBP superfamily domain; Region: PBP_like_2; cl17296
857087013230	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
857087013231	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
857087013232	folate binding site [chemical binding]; other site
857087013233	NADP+ binding site [chemical binding]; other site
857087013234	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
857087013235	active site
857087013236	homodimer interface [polypeptide binding]; other site
857087013237	VID27 cytoplasmic protein; Region: VID27; pfam08553
857087013238	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
857087013239	TPP-binding site [chemical binding]; other site
857087013240	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
857087013241	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
857087013242	PYR/PP interface [polypeptide binding]; other site
857087013243	dimer interface [polypeptide binding]; other site
857087013244	TPP binding site [chemical binding]; other site
857087013245	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
857087013246	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
857087013247	dimer interface [polypeptide binding]; other site
857087013248	active site
857087013249	hypothetical protein; Reviewed; Region: PRK12497
857087013250	LppC putative lipoprotein; Region: LppC; pfam04348
857087013251	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
857087013252	putative ligand binding site [chemical binding]; other site
857087013253	Predicted methyltransferases [General function prediction only]; Region: COG0313
857087013254	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
857087013255	putative SAM binding site [chemical binding]; other site
857087013256	putative homodimer interface [polypeptide binding]; other site
857087013257	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
857087013258	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
857087013259	metal binding site [ion binding]; metal-binding site
857087013260	active site
857087013261	I-site; other site
857087013262	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533
857087013263	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
857087013264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
857087013265	Coenzyme A binding pocket [chemical binding]; other site
857087013266	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
857087013267	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
857087013268	NADP binding site [chemical binding]; other site
857087013269	dimer interface [polypeptide binding]; other site
857087013270	Homeodomain-like domain; Region: HTH_23; pfam13384
857087013271	Winged helix-turn helix; Region: HTH_29; pfam13551
857087013272	Homeodomain-like domain; Region: HTH_32; pfam13565
857087013273	DDE superfamily endonuclease; Region: DDE_3; pfam13358
857087013274	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
857087013275	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
857087013276	HSP70 interaction site [polypeptide binding]; other site
857087013277	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
857087013278	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
857087013279	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
857087013280	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
857087013281	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
857087013282	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
857087013283	transmembrane helices; other site
857087013284	TrkA-C domain; Region: TrkA_C; pfam02080
857087013285	TrkA-C domain; Region: TrkA_C; pfam02080
857087013286	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
857087013287	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
857087013288	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
857087013289	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
857087013290	G1 box; other site
857087013291	putative GEF interaction site [polypeptide binding]; other site
857087013292	GTP/Mg2+ binding site [chemical binding]; other site
857087013293	Switch I region; other site
857087013294	G2 box; other site
857087013295	G3 box; other site
857087013296	Switch II region; other site
857087013297	G4 box; other site
857087013298	G5 box; other site
857087013299	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
857087013300	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
857087013301	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
857087013302	active site residue [active]
857087013303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
857087013304	Transcriptional regulator [Transcription]; Region: LysR; COG0583
857087013305	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
857087013306	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
857087013307	putative effector binding pocket; other site
857087013308	dimerization interface [polypeptide binding]; other site
857087013309	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
857087013310	metal binding site [ion binding]; metal-binding site
857087013311	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
857087013312	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
857087013313	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
857087013314	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
857087013315	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
857087013316	catalytic residue [active]
857087013317	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
857087013318	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
857087013319	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
857087013320	active site
857087013321	HIGH motif; other site
857087013322	nucleotide binding site [chemical binding]; other site
857087013323	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
857087013324	KMSK motif region; other site
857087013325	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
857087013326	tRNA binding surface [nucleotide binding]; other site
857087013327	anticodon binding site; other site
857087013328	Sporulation related domain; Region: SPOR; pfam05036
857087013329	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
857087013330	dimerization interface [polypeptide binding]; other site
857087013331	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
857087013332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
857087013333	dimer interface [polypeptide binding]; other site
857087013334	phosphorylation site [posttranslational modification]
857087013335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
857087013336	ATP binding site [chemical binding]; other site
857087013337	Mg2+ binding site [ion binding]; other site
857087013338	G-X-G motif; other site
857087013339	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
857087013340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
857087013341	active site
857087013342	phosphorylation site [posttranslational modification]
857087013343	intermolecular recognition site; other site
857087013344	dimerization interface [polypeptide binding]; other site
857087013345	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
857087013346	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
857087013347	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
857087013348	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
857087013349	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
857087013350	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
857087013351	nucleoside/Zn binding site; other site
857087013352	dimer interface [polypeptide binding]; other site
857087013353	catalytic motif [active]
857087013354	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
857087013355	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
857087013356	glutamine binding [chemical binding]; other site
857087013357	catalytic triad [active]
857087013358	anthranilate synthase component I; Provisional; Region: PRK13565
857087013359	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
857087013360	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
857087013361	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
857087013362	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
857087013363	transcription termination factor Rho; Provisional; Region: PRK12678
857087013364	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
857087013365	potassium uptake protein; Region: kup; TIGR00794
857087013366	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
857087013367	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
857087013368	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
857087013369	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
857087013370	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
857087013371	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
857087013372	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
857087013373	RimK-like ATP-grasp domain; Region: RimK; pfam08443
857087013374	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
857087013375	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
857087013376	Cupin domain; Region: Cupin_2; cl17218
857087013377	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
857087013378	intersubunit interface [polypeptide binding]; other site
857087013379	active site
857087013380	Zn2+ binding site [ion binding]; other site
857087013381	FOG: CBS domain [General function prediction only]; Region: COG0517
857087013382	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
857087013383	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
857087013384	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
857087013385	putative catalytic cysteine [active]
857087013386	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
857087013387	GTP/Mg2+ binding site [chemical binding]; other site
857087013388	G4 box; other site
857087013389	G5 box; other site
857087013390	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087013391	G1 box; other site
857087013392	G1 box; other site
857087013393	GTP/Mg2+ binding site [chemical binding]; other site
857087013394	G2 box; other site
857087013395	Switch I region; other site
857087013396	Switch I region; other site
857087013397	G3 box; other site
857087013398	G3 box; other site
857087013399	Switch II region; other site
857087013400	Switch II region; other site
857087013401	G4 box; other site
857087013402	G5 box; other site
857087013403	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
857087013404	G1 box; other site
857087013405	GTP/Mg2+ binding site [chemical binding]; other site
857087013406	G2 box; other site
857087013407	Switch I region; other site
857087013408	G3 box; other site
857087013409	Switch II region; other site
857087013410	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
857087013411	DNA recombination protein RmuC; Provisional; Region: PRK10361
857087013412	RmuC family; Region: RmuC; pfam02646
857087013413	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
857087013414	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
857087013415	inhibitor-cofactor binding pocket; inhibition site
857087013416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
857087013417	catalytic residue [active]
857087013418	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
857087013419	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
857087013420	catalytic site [active]
857087013421	G-X2-G-X-G-K; other site