-- dump date   	20140619_145157
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
754476000001	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
754476000002	Ligand Binding Site [chemical binding]; other site
754476000003	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
754476000004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476000005	FeS/SAM binding site; other site
754476000006	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
754476000007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476000008	binding surface
754476000009	TPR motif; other site
754476000010	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
754476000011	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476000012	ligand binding site [chemical binding]; other site
754476000013	translocation protein TolB; Provisional; Region: tolB; PRK04922
754476000014	TolB amino-terminal domain; Region: TolB_N; pfam04052
754476000015	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
754476000016	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
754476000017	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
754476000018	TonB C terminal; Region: TonB_2; pfam13103
754476000019	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476000020	TolR protein; Region: tolR; TIGR02801
754476000021	TolQ protein; Region: tolQ; TIGR02796
754476000022	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
754476000023	active site
754476000024	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
754476000025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476000026	Walker A motif; other site
754476000027	ATP binding site [chemical binding]; other site
754476000028	Walker B motif; other site
754476000029	arginine finger; other site
754476000030	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
754476000031	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
754476000032	RuvA N terminal domain; Region: RuvA_N; pfam01330
754476000033	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
754476000034	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
754476000035	active site
754476000036	putative DNA-binding cleft [nucleotide binding]; other site
754476000037	dimer interface [polypeptide binding]; other site
754476000038	hypothetical protein; Validated; Region: PRK00110
754476000039	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
754476000040	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
754476000041	homodimer interface [polypeptide binding]; other site
754476000042	substrate-cofactor binding pocket; other site
754476000043	catalytic residue [active]
754476000044	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
754476000045	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
754476000046	metal binding triad; other site
754476000047	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
754476000048	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
754476000049	metal binding triad; other site
754476000050	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
754476000051	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
754476000052	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
754476000053	ring oligomerisation interface [polypeptide binding]; other site
754476000054	ATP/Mg binding site [chemical binding]; other site
754476000055	stacking interactions; other site
754476000056	hinge regions; other site
754476000057	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
754476000058	oligomerisation interface [polypeptide binding]; other site
754476000059	mobile loop; other site
754476000060	roof hairpin; other site
754476000061	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
754476000062	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
754476000063	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476000064	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
754476000065	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476000066	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476000067	metal binding site [ion binding]; metal-binding site
754476000068	active site
754476000069	I-site; other site
754476000070	Low molecular weight phosphatase family; Region: LMWPc; cd00115
754476000071	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
754476000072	active site
754476000073	Bacterial SH3 domain homologues; Region: SH3b; smart00287
754476000074	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
754476000075	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
754476000076	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
754476000077	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
754476000078	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
754476000079	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476000080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476000081	Walker A/P-loop; other site
754476000082	ATP binding site [chemical binding]; other site
754476000083	Q-loop/lid; other site
754476000084	ABC transporter signature motif; other site
754476000085	Walker B; other site
754476000086	D-loop; other site
754476000087	H-loop/switch region; other site
754476000088	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
754476000089	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
754476000090	N-acetylglutamate synthase; Validated; Region: PRK05279
754476000091	putative feedback inhibition sensing region; other site
754476000092	putative nucleotide binding site [chemical binding]; other site
754476000093	putative substrate binding site [chemical binding]; other site
754476000094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476000095	Coenzyme A binding pocket [chemical binding]; other site
754476000096	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
754476000097	putative active site [active]
754476000098	Ap4A binding site [chemical binding]; other site
754476000099	nudix motif; other site
754476000100	putative metal binding site [ion binding]; other site
754476000101	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
754476000102	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
754476000103	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
754476000104	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
754476000105	GatB domain; Region: GatB_Yqey; smart00845
754476000106	Uncharacterized conserved protein [Function unknown]; Region: COG3287
754476000107	FIST N domain; Region: FIST; pfam08495
754476000108	FIST C domain; Region: FIST_C; pfam10442
754476000109	Glutamate-cysteine ligase; Region: GshA; pfam08886
754476000110	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
754476000111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000112	Response regulator receiver domain; Region: Response_reg; pfam00072
754476000113	active site
754476000114	phosphorylation site [posttranslational modification]
754476000115	intermolecular recognition site; other site
754476000116	dimerization interface [polypeptide binding]; other site
754476000117	Response regulator receiver domain; Region: Response_reg; pfam00072
754476000118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000119	active site
754476000120	phosphorylation site [posttranslational modification]
754476000121	intermolecular recognition site; other site
754476000122	dimerization interface [polypeptide binding]; other site
754476000123	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
754476000124	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476000125	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476000126	dimer interface [polypeptide binding]; other site
754476000127	putative CheW interface [polypeptide binding]; other site
754476000128	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
754476000129	putative binding surface; other site
754476000130	active site
754476000131	Hpt domain; Region: Hpt; pfam01627
754476000132	putative binding surface; other site
754476000133	active site
754476000134	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
754476000135	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
754476000136	putative binding surface; other site
754476000137	active site
754476000138	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
754476000139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476000140	ATP binding site [chemical binding]; other site
754476000141	Mg2+ binding site [ion binding]; other site
754476000142	G-X-G motif; other site
754476000143	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
754476000144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000145	Response regulator receiver domain; Region: Response_reg; pfam00072
754476000146	active site
754476000147	phosphorylation site [posttranslational modification]
754476000148	intermolecular recognition site; other site
754476000149	dimerization interface [polypeptide binding]; other site
754476000150	CheW-like domain; Region: CheW; pfam01584
754476000151	lytic murein transglycosylase; Provisional; Region: PRK11619
754476000152	murein hydrolase B; Provisional; Region: PRK10760; cl17906
754476000153	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476000154	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476000155	catalytic residue [active]
754476000156	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
754476000157	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
754476000158	active site
754476000159	NTP binding site [chemical binding]; other site
754476000160	metal binding triad [ion binding]; metal-binding site
754476000161	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
754476000162	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476000163	Zn2+ binding site [ion binding]; other site
754476000164	Mg2+ binding site [ion binding]; other site
754476000165	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
754476000166	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
754476000167	trimer interface I [polypeptide binding]; other site
754476000168	putative substrate binding pocket [chemical binding]; other site
754476000169	trimer interface II [polypeptide binding]; other site
754476000170	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
754476000171	ATP-grasp domain; Region: ATP-grasp_4; cl17255
754476000172	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
754476000173	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
754476000174	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
754476000175	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
754476000176	active site
754476000177	ATP-grasp domain; Region: ATP-grasp_4; cl17255
754476000178	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
754476000179	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
754476000180	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
754476000181	chorismate binding enzyme; Region: Chorismate_bind; cl10555
754476000182	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
754476000183	nucleotide binding site [chemical binding]; other site
754476000184	substrate binding site [chemical binding]; other site
754476000185	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
754476000186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
754476000187	catalytic residue [active]
754476000188	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
754476000189	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476000190	Walker A motif; other site
754476000191	ATP binding site [chemical binding]; other site
754476000192	Walker B motif; other site
754476000193	cell division protein DamX; Validated; Region: PRK10905
754476000194	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
754476000195	active site
754476000196	dimer interface [polypeptide binding]; other site
754476000197	metal binding site [ion binding]; metal-binding site
754476000198	shikimate kinase; Reviewed; Region: aroK; PRK00131
754476000199	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
754476000200	ADP binding site [chemical binding]; other site
754476000201	magnesium binding site [ion binding]; other site
754476000202	putative shikimate binding site; other site
754476000203	AMIN domain; Region: AMIN; pfam11741
754476000204	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
754476000205	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000206	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
754476000207	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
754476000208	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
754476000209	Pilus assembly protein, PilP; Region: PilP; pfam04351
754476000210	Pilus assembly protein, PilO; Region: PilO; pfam04350
754476000211	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
754476000212	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
754476000213	Competence protein A; Region: Competence_A; pfam11104
754476000214	Cell division protein FtsA; Region: FtsA; cl17206
754476000215	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
754476000216	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
754476000217	Transglycosylase; Region: Transgly; pfam00912
754476000218	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
754476000219	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476000220	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476000221	dimer interface [polypeptide binding]; other site
754476000222	putative CheW interface [polypeptide binding]; other site
754476000223	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
754476000224	NnrS protein; Region: NnrS; pfam05940
754476000225	Predicted transcriptional regulator [Transcription]; Region: COG1959
754476000226	Transcriptional regulator; Region: Rrf2; cl17282
754476000227	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
754476000228	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
754476000229	Hemerythrin-like domain; Region: Hr-like; cd12108
754476000230	Fe binding site [ion binding]; other site
754476000231	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
754476000232	Peptidase family M48; Region: Peptidase_M48; pfam01435
754476000233	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
754476000234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476000235	S-adenosylmethionine binding site [chemical binding]; other site
754476000236	Cation transport protein; Region: TrkH; cl17365
754476000237	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
754476000238	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
754476000239	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
754476000240	putative active site [active]
754476000241	catalytic triad [active]
754476000242	putative dimer interface [polypeptide binding]; other site
754476000243	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
754476000244	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
754476000245	Transporter associated domain; Region: CorC_HlyC; smart01091
754476000246	metal-binding heat shock protein; Provisional; Region: PRK00016
754476000247	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
754476000248	PhoH-like protein; Region: PhoH; pfam02562
754476000249	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
754476000250	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
754476000251	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476000252	FeS/SAM binding site; other site
754476000253	TRAM domain; Region: TRAM; pfam01938
754476000254	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
754476000255	Thrombospondin C-terminal region; Region: TSP_C; pfam05735
754476000256	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
754476000257	uncharacterized domain; Region: TIGR00702
754476000258	YcaO-like family; Region: YcaO; pfam02624
754476000259	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
754476000260	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
754476000261	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
754476000262	TrkA-N domain; Region: TrkA_N; pfam02254
754476000263	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
754476000264	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
754476000265	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
754476000266	putative uracil binding site [chemical binding]; other site
754476000267	putative active site [active]
754476000268	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
754476000269	Predicted membrane protein [Function unknown]; Region: COG3174
754476000270	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
754476000271	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
754476000272	putative active site [active]
754476000273	putative catalytic site [active]
754476000274	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
754476000275	PLD-like domain; Region: PLDc_2; pfam13091
754476000276	putative active site [active]
754476000277	putative catalytic site [active]
754476000278	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
754476000279	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
754476000280	active site
754476000281	metal binding site [ion binding]; metal-binding site
754476000282	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
754476000283	PBP superfamily domain; Region: PBP_like_2; cl17296
754476000284	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
754476000285	malate dehydrogenase; Reviewed; Region: PRK06223
754476000286	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
754476000287	NAD(P) binding site [chemical binding]; other site
754476000288	dimer interface [polypeptide binding]; other site
754476000289	tetramer (dimer of dimers) interface [polypeptide binding]; other site
754476000290	substrate binding site [chemical binding]; other site
754476000291	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
754476000292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
754476000293	MOSC domain; Region: MOSC; pfam03473
754476000294	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
754476000295	Cytochrome P450; Region: p450; cl12078
754476000296	hypothetical protein; Reviewed; Region: PRK00024
754476000297	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
754476000298	MPN+ (JAMM) motif; other site
754476000299	Zinc-binding site [ion binding]; other site
754476000300	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476000301	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
754476000302	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476000303	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
754476000304	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
754476000305	Hemerythrin; Region: Hemerythrin; cd12107
754476000306	thymidylate synthase; Reviewed; Region: thyA; PRK01827
754476000307	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
754476000308	dimerization interface [polypeptide binding]; other site
754476000309	active site
754476000310	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
754476000311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476000312	Walker A motif; other site
754476000313	ATP binding site [chemical binding]; other site
754476000314	Walker B motif; other site
754476000315	arginine finger; other site
754476000316	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476000317	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
754476000318	Family description; Region: DsbD_2; pfam13386
754476000319	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
754476000320	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
754476000321	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
754476000322	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
754476000323	transcriptional regulator PhoU; Provisional; Region: PRK11115
754476000324	PhoU domain; Region: PhoU; pfam01895
754476000325	PhoU domain; Region: PhoU; pfam01895
754476000326	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
754476000327	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
754476000328	Walker A/P-loop; other site
754476000329	ATP binding site [chemical binding]; other site
754476000330	Q-loop/lid; other site
754476000331	ABC transporter signature motif; other site
754476000332	Walker B; other site
754476000333	D-loop; other site
754476000334	H-loop/switch region; other site
754476000335	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
754476000336	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
754476000337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476000338	dimer interface [polypeptide binding]; other site
754476000339	conserved gate region; other site
754476000340	putative PBP binding loops; other site
754476000341	ABC-ATPase subunit interface; other site
754476000342	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
754476000343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476000344	conserved gate region; other site
754476000345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476000346	ABC-ATPase subunit interface; other site
754476000347	PBP superfamily domain; Region: PBP_like_2; cl17296
754476000348	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
754476000349	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
754476000350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476000351	dimer interface [polypeptide binding]; other site
754476000352	phosphorylation site [posttranslational modification]
754476000353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476000354	ATP binding site [chemical binding]; other site
754476000355	Mg2+ binding site [ion binding]; other site
754476000356	G-X-G motif; other site
754476000357	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
754476000358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000359	active site
754476000360	phosphorylation site [posttranslational modification]
754476000361	intermolecular recognition site; other site
754476000362	dimerization interface [polypeptide binding]; other site
754476000363	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476000364	DNA binding site [nucleotide binding]
754476000365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476000366	putative substrate translocation pore; other site
754476000367	Major Facilitator Superfamily; Region: MFS_1; pfam07690
754476000368	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
754476000369	Phosphate transporter family; Region: PHO4; pfam01384
754476000370	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
754476000371	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
754476000372	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
754476000373	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
754476000374	DsbD alpha interface [polypeptide binding]; other site
754476000375	catalytic residues [active]
754476000376	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
754476000377	Dehydroquinase class II; Region: DHquinase_II; pfam01220
754476000378	trimer interface [polypeptide binding]; other site
754476000379	active site
754476000380	dimer interface [polypeptide binding]; other site
754476000381	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
754476000382	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
754476000383	carboxyltransferase (CT) interaction site; other site
754476000384	biotinylation site [posttranslational modification]; other site
754476000385	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
754476000386	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
754476000387	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
754476000388	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
754476000389	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
754476000390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476000391	S-adenosylmethionine binding site [chemical binding]; other site
754476000392	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
754476000393	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
754476000394	FMN binding site [chemical binding]; other site
754476000395	active site
754476000396	catalytic residues [active]
754476000397	substrate binding site [chemical binding]; other site
754476000398	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
754476000399	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
754476000400	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
754476000401	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
754476000402	purine monophosphate binding site [chemical binding]; other site
754476000403	dimer interface [polypeptide binding]; other site
754476000404	putative catalytic residues [active]
754476000405	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
754476000406	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
754476000407	adenylate cyclase; Provisional; Region: cyaA; PRK09450
754476000408	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
754476000409	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
754476000410	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
754476000411	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
754476000412	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
754476000413	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
754476000414	Predicted membrane protein [Function unknown]; Region: COG4325
754476000415	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
754476000416	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476000417	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476000418	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
754476000419	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476000420	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476000421	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
754476000422	Protein export membrane protein; Region: SecD_SecF; cl14618
754476000423	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
754476000424	BCCT family transporter; Region: BCCT; pfam02028
754476000425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476000426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476000427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
754476000428	dimerization interface [polypeptide binding]; other site
754476000429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476000430	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
754476000431	putative active site [active]
754476000432	heme pocket [chemical binding]; other site
754476000433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476000434	putative active site [active]
754476000435	heme pocket [chemical binding]; other site
754476000436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476000437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476000438	metal binding site [ion binding]; metal-binding site
754476000439	active site
754476000440	I-site; other site
754476000441	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
754476000442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
754476000443	dimer interface [polypeptide binding]; other site
754476000444	active site
754476000445	metal binding site [ion binding]; metal-binding site
754476000446	glutathione binding site [chemical binding]; other site
754476000447	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
754476000448	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
754476000449	Cl binding site [ion binding]; other site
754476000450	oligomer interface [polypeptide binding]; other site
754476000451	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476000452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476000453	S-adenosylmethionine binding site [chemical binding]; other site
754476000454	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
754476000455	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
754476000456	trmE is a tRNA modification GTPase; Region: trmE; cd04164
754476000457	G1 box; other site
754476000458	GTP/Mg2+ binding site [chemical binding]; other site
754476000459	Switch I region; other site
754476000460	G2 box; other site
754476000461	Switch II region; other site
754476000462	G3 box; other site
754476000463	G4 box; other site
754476000464	G5 box; other site
754476000465	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
754476000466	membrane protein insertase; Provisional; Region: PRK01318
754476000467	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
754476000468	Ribonuclease P; Region: Ribonuclease_P; cl00457
754476000469	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
754476000470	DnaA N-terminal domain; Region: DnaA_N; pfam11638
754476000471	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
754476000472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476000473	Walker A motif; other site
754476000474	ATP binding site [chemical binding]; other site
754476000475	Walker B motif; other site
754476000476	arginine finger; other site
754476000477	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
754476000478	DnaA box-binding interface [nucleotide binding]; other site
754476000479	DNA polymerase III subunit beta; Validated; Region: PRK05643
754476000480	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
754476000481	putative DNA binding surface [nucleotide binding]; other site
754476000482	dimer interface [polypeptide binding]; other site
754476000483	beta-clamp/clamp loader binding surface; other site
754476000484	beta-clamp/translesion DNA polymerase binding surface; other site
754476000485	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
754476000486	HemY protein N-terminus; Region: HemY_N; pfam07219
754476000487	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
754476000488	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
754476000489	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
754476000490	active site
754476000491	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
754476000492	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
754476000493	domain interfaces; other site
754476000494	active site
754476000495	argininosuccinate lyase; Provisional; Region: PRK00855
754476000496	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
754476000497	active sites [active]
754476000498	tetramer interface [polypeptide binding]; other site
754476000499	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
754476000500	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
754476000501	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476000502	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
754476000503	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476000504	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000505	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
754476000506	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000507	N-terminal plug; other site
754476000508	ligand-binding site [chemical binding]; other site
754476000509	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
754476000510	FecR protein; Region: FecR; pfam04773
754476000511	RNA polymerase sigma factor; Reviewed; Region: PRK12523
754476000512	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000513	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
754476000514	hydroperoxidase II; Provisional; Region: katE; PRK11249
754476000515	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
754476000516	heme binding pocket [chemical binding]; other site
754476000517	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
754476000518	domain interactions; other site
754476000519	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
754476000520	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
754476000521	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000522	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
754476000523	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000524	N-terminal plug; other site
754476000525	ligand-binding site [chemical binding]; other site
754476000526	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000527	FecR protein; Region: FecR; pfam04773
754476000528	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
754476000529	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000530	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000531	DNA binding residues [nucleotide binding]
754476000532	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
754476000533	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476000534	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476000535	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
754476000536	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000537	N-terminal plug; other site
754476000538	ligand-binding site [chemical binding]; other site
754476000539	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
754476000540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476000541	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
754476000542	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000543	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
754476000544	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000545	N-terminal plug; other site
754476000546	ligand-binding site [chemical binding]; other site
754476000547	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000548	FecR protein; Region: FecR; pfam04773
754476000549	RNA polymerase sigma factor; Provisional; Region: PRK12528
754476000550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000552	DNA binding residues [nucleotide binding]
754476000553	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476000554	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476000555	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000556	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
754476000557	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000558	N-terminal plug; other site
754476000559	ligand-binding site [chemical binding]; other site
754476000560	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000561	FecR protein; Region: FecR; pfam04773
754476000562	RNA polymerase sigma factor; Provisional; Region: PRK12528
754476000563	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000564	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000565	DNA binding residues [nucleotide binding]
754476000566	Fic family protein [Function unknown]; Region: COG3177
754476000567	Fic/DOC family; Region: Fic; pfam02661
754476000568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
754476000569	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000570	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
754476000571	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000572	N-terminal plug; other site
754476000573	ligand-binding site [chemical binding]; other site
754476000574	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000575	FecR protein; Region: FecR; pfam04773
754476000576	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000577	DNA binding residues [nucleotide binding]
754476000578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000579	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000580	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
754476000581	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000582	N-terminal plug; other site
754476000583	ligand-binding site [chemical binding]; other site
754476000584	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000585	FecR protein; Region: FecR; pfam04773
754476000586	RNA polymerase sigma factor; Provisional; Region: PRK12528
754476000587	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476000588	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000589	DNA binding residues [nucleotide binding]
754476000590	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476000591	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476000592	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000593	N-terminal plug; other site
754476000594	ligand-binding site [chemical binding]; other site
754476000595	fec operon regulator FecR; Reviewed; Region: PRK09774
754476000596	FecR protein; Region: FecR; pfam04773
754476000597	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
754476000598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476000599	DNA binding residues [nucleotide binding]
754476000600	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
754476000601	putative metal binding site [ion binding]; other site
754476000602	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
754476000603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476000604	Coenzyme A binding pocket [chemical binding]; other site
754476000605	Peptidase_C39 like family; Region: DUF3335; pfam11814
754476000606	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
754476000607	active site
754476000608	Zn binding site [ion binding]; other site
754476000609	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
754476000610	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
754476000611	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
754476000612	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476000613	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000614	N-terminal plug; other site
754476000615	ligand-binding site [chemical binding]; other site
754476000616	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
754476000617	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
754476000618	HSP70 interaction site [polypeptide binding]; other site
754476000619	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
754476000620	substrate binding site [polypeptide binding]; other site
754476000621	dimer interface [polypeptide binding]; other site
754476000622	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
754476000623	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
754476000624	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
754476000625	protein binding site [polypeptide binding]; other site
754476000626	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
754476000627	protein binding site [polypeptide binding]; other site
754476000628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
754476000629	SnoaL-like domain; Region: SnoaL_2; pfam12680
754476000630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476000631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476000632	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
754476000633	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
754476000634	heme binding site [chemical binding]; other site
754476000635	ferroxidase pore; other site
754476000636	ferroxidase diiron center [ion binding]; other site
754476000637	PemK-like protein; Region: PemK; pfam02452
754476000638	Central kinetochore-associated; Region: Kinetocho_Slk19; pfam12709
754476000639	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
754476000640	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
754476000641	Substrate binding site; other site
754476000642	Mg++ binding site; other site
754476000643	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
754476000644	active site
754476000645	substrate binding site [chemical binding]; other site
754476000646	CoA binding site [chemical binding]; other site
754476000647	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
754476000648	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
754476000649	gamma subunit interface [polypeptide binding]; other site
754476000650	epsilon subunit interface [polypeptide binding]; other site
754476000651	LBP interface [polypeptide binding]; other site
754476000652	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
754476000653	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
754476000654	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
754476000655	alpha subunit interaction interface [polypeptide binding]; other site
754476000656	Walker A motif; other site
754476000657	ATP binding site [chemical binding]; other site
754476000658	Walker B motif; other site
754476000659	inhibitor binding site; inhibition site
754476000660	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
754476000661	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
754476000662	core domain interface [polypeptide binding]; other site
754476000663	delta subunit interface [polypeptide binding]; other site
754476000664	epsilon subunit interface [polypeptide binding]; other site
754476000665	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
754476000666	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
754476000667	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
754476000668	beta subunit interaction interface [polypeptide binding]; other site
754476000669	Walker A motif; other site
754476000670	ATP binding site [chemical binding]; other site
754476000671	Walker B motif; other site
754476000672	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
754476000673	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
754476000674	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
754476000675	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
754476000676	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
754476000677	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
754476000678	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
754476000679	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
754476000680	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
754476000681	ParB-like nuclease domain; Region: ParB; smart00470
754476000682	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
754476000683	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
754476000684	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476000685	Magnesium ion binding site [ion binding]; other site
754476000686	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
754476000687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476000688	S-adenosylmethionine binding site [chemical binding]; other site
754476000689	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
754476000690	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
754476000691	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
754476000692	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
754476000693	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
754476000694	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
754476000695	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
754476000696	Nitrogen regulatory protein P-II; Region: P-II; smart00938
754476000697	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
754476000698	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
754476000699	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
754476000700	substrate binding site [chemical binding]; other site
754476000701	active site
754476000702	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
754476000703	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
754476000704	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
754476000705	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
754476000706	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
754476000707	active site
754476000708	dimer interface [polypeptide binding]; other site
754476000709	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
754476000710	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
754476000711	active site
754476000712	FMN binding site [chemical binding]; other site
754476000713	substrate binding site [chemical binding]; other site
754476000714	3Fe-4S cluster binding site [ion binding]; other site
754476000715	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
754476000716	domain interface; other site
754476000717	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
754476000718	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
754476000719	ATP-grasp domain; Region: ATP-grasp; pfam02222
754476000720	Rdx family; Region: Rdx; cl01407
754476000721	DNA topoisomerase I; Validated; Region: PRK06599
754476000722	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
754476000723	active site
754476000724	interdomain interaction site; other site
754476000725	putative metal-binding site [ion binding]; other site
754476000726	nucleotide binding site [chemical binding]; other site
754476000727	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
754476000728	domain I; other site
754476000729	DNA binding groove [nucleotide binding]
754476000730	phosphate binding site [ion binding]; other site
754476000731	domain II; other site
754476000732	domain III; other site
754476000733	nucleotide binding site [chemical binding]; other site
754476000734	catalytic site [active]
754476000735	domain IV; other site
754476000736	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
754476000737	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
754476000738	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
754476000739	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
754476000740	Protein of unknown function (DUF494); Region: DUF494; pfam04361
754476000741	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
754476000742	DNA protecting protein DprA; Region: dprA; TIGR00732
754476000743	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476000744	Cytochrome c553 [Energy production and conversion]; Region: COG2863
754476000745	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
754476000746	active site
754476000747	catalytic residues [active]
754476000748	metal binding site [ion binding]; metal-binding site
754476000749	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
754476000750	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
754476000751	putative active site [active]
754476000752	substrate binding site [chemical binding]; other site
754476000753	putative cosubstrate binding site; other site
754476000754	catalytic site [active]
754476000755	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
754476000756	substrate binding site [chemical binding]; other site
754476000757	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
754476000758	16S rRNA methyltransferase B; Provisional; Region: PRK10901
754476000759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476000760	S-adenosylmethionine binding site [chemical binding]; other site
754476000761	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
754476000762	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
754476000763	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476000764	dimerization interface [polypeptide binding]; other site
754476000765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476000766	dimer interface [polypeptide binding]; other site
754476000767	phosphorylation site [posttranslational modification]
754476000768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476000769	ATP binding site [chemical binding]; other site
754476000770	Mg2+ binding site [ion binding]; other site
754476000771	G-X-G motif; other site
754476000772	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476000773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000774	active site
754476000775	phosphorylation site [posttranslational modification]
754476000776	intermolecular recognition site; other site
754476000777	dimerization interface [polypeptide binding]; other site
754476000778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476000779	Walker A motif; other site
754476000780	ATP binding site [chemical binding]; other site
754476000781	Walker B motif; other site
754476000782	arginine finger; other site
754476000783	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476000784	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
754476000785	TrkA-N domain; Region: TrkA_N; pfam02254
754476000786	TrkA-C domain; Region: TrkA_C; pfam02080
754476000787	TrkA-N domain; Region: TrkA_N; pfam02254
754476000788	TrkA-C domain; Region: TrkA_C; pfam02080
754476000789	hypothetical protein; Validated; Region: PRK00228
754476000790	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
754476000791	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476000792	active site
754476000793	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
754476000794	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
754476000795	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
754476000796	dihydroorotase; Provisional; Region: PRK07627
754476000797	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
754476000798	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
754476000799	active site
754476000800	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
754476000801	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
754476000802	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
754476000803	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
754476000804	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
754476000805	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
754476000806	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
754476000807	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
754476000808	Walker A/P-loop; other site
754476000809	ATP binding site [chemical binding]; other site
754476000810	Q-loop/lid; other site
754476000811	ABC transporter signature motif; other site
754476000812	Walker B; other site
754476000813	D-loop; other site
754476000814	H-loop/switch region; other site
754476000815	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
754476000816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476000817	dimer interface [polypeptide binding]; other site
754476000818	conserved gate region; other site
754476000819	ABC-ATPase subunit interface; other site
754476000820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476000821	dimer interface [polypeptide binding]; other site
754476000822	conserved gate region; other site
754476000823	putative PBP binding loops; other site
754476000824	ABC-ATPase subunit interface; other site
754476000825	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
754476000826	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
754476000827	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
754476000828	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476000829	N-terminal plug; other site
754476000830	ligand-binding site [chemical binding]; other site
754476000831	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
754476000832	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
754476000833	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
754476000834	Domain of unknown function DUF20; Region: UPF0118; pfam01594
754476000835	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
754476000836	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476000837	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
754476000838	Protein export membrane protein; Region: SecD_SecF; cl14618
754476000839	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
754476000840	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
754476000841	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
754476000842	MAPEG family; Region: MAPEG; cl09190
754476000843	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
754476000844	AMP binding site [chemical binding]; other site
754476000845	metal binding site [ion binding]; metal-binding site
754476000846	active site
754476000847	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
754476000848	domain_subunit interface; other site
754476000849	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
754476000850	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
754476000851	FTR, proximal lobe; Region: FTR_C; pfam02741
754476000852	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
754476000853	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
754476000854	active site
754476000855	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
754476000856	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
754476000857	putative [4Fe-4S] binding site [ion binding]; other site
754476000858	putative molybdopterin cofactor binding site [chemical binding]; other site
754476000859	Sporulation related domain; Region: SPOR; pfam05036
754476000860	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
754476000861	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
754476000862	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
754476000863	active site
754476000864	HIGH motif; other site
754476000865	nucleotide binding site [chemical binding]; other site
754476000866	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
754476000867	KMSK motif region; other site
754476000868	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
754476000869	tRNA binding surface [nucleotide binding]; other site
754476000870	anticodon binding site; other site
754476000871	primosome assembly protein PriA; Validated; Region: PRK05580
754476000872	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476000873	ATP binding site [chemical binding]; other site
754476000874	putative Mg++ binding site [ion binding]; other site
754476000875	helicase superfamily c-terminal domain; Region: HELICc; smart00490
754476000876	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
754476000877	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
754476000878	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
754476000879	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
754476000880	folate binding site [chemical binding]; other site
754476000881	NADP+ binding site [chemical binding]; other site
754476000882	Phosphate-starvation-inducible E; Region: PsiE; cl01264
754476000883	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
754476000884	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476000885	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476000886	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
754476000887	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
754476000888	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
754476000889	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
754476000890	nucleotide binding site/active site [active]
754476000891	HIT family signature motif; other site
754476000892	catalytic residue [active]
754476000893	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
754476000894	metal binding site [ion binding]; metal-binding site
754476000895	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
754476000896	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
754476000897	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
754476000898	substrate binding site [chemical binding]; other site
754476000899	glutamase interaction surface [polypeptide binding]; other site
754476000900	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
754476000901	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
754476000902	catalytic residues [active]
754476000903	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
754476000904	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
754476000905	putative active site [active]
754476000906	oxyanion strand; other site
754476000907	catalytic triad [active]
754476000908	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
754476000909	putative active site pocket [active]
754476000910	4-fold oligomerization interface [polypeptide binding]; other site
754476000911	metal binding residues [ion binding]; metal-binding site
754476000912	3-fold/trimer interface [polypeptide binding]; other site
754476000913	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
754476000914	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
754476000915	ligand binding site [chemical binding]; other site
754476000916	flexible hinge region; other site
754476000917	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
754476000918	putative switch regulator; other site
754476000919	non-specific DNA interactions [nucleotide binding]; other site
754476000920	DNA binding site [nucleotide binding]
754476000921	sequence specific DNA binding site [nucleotide binding]; other site
754476000922	putative cAMP binding site [chemical binding]; other site
754476000923	OmpW family; Region: OmpW; cl17427
754476000924	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
754476000925	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
754476000926	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
754476000927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476000928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476000929	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
754476000930	dimerization interface [polypeptide binding]; other site
754476000931	Rubredoxin [Energy production and conversion]; Region: COG1773
754476000932	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
754476000933	iron binding site [ion binding]; other site
754476000934	recombination protein F; Reviewed; Region: recF; PRK00064
754476000935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476000936	Walker A/P-loop; other site
754476000937	ATP binding site [chemical binding]; other site
754476000938	Q-loop/lid; other site
754476000939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476000940	ABC transporter signature motif; other site
754476000941	Walker B; other site
754476000942	D-loop; other site
754476000943	H-loop/switch region; other site
754476000944	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
754476000945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476000946	ATP binding site [chemical binding]; other site
754476000947	Mg2+ binding site [ion binding]; other site
754476000948	G-X-G motif; other site
754476000949	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
754476000950	anchoring element; other site
754476000951	dimer interface [polypeptide binding]; other site
754476000952	ATP binding site [chemical binding]; other site
754476000953	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
754476000954	active site
754476000955	putative metal-binding site [ion binding]; other site
754476000956	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
754476000957	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
754476000958	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476000959	Flavoprotein; Region: Flavoprotein; pfam02441
754476000960	dihydropteroate synthase-related protein; Region: TIGR00284
754476000961	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
754476000962	substrate binding pocket [chemical binding]; other site
754476000963	dimer interface [polypeptide binding]; other site
754476000964	inhibitor binding site; inhibition site
754476000965	Protein of unknown function (DUF447); Region: DUF447; pfam04289
754476000966	hypothetical protein; Provisional; Region: PRK02227
754476000967	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
754476000968	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
754476000969	THF binding site; other site
754476000970	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
754476000971	substrate binding site [chemical binding]; other site
754476000972	THF binding site; other site
754476000973	zinc-binding site [ion binding]; other site
754476000974	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476000975	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476000976	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
754476000977	dimerization interface [polypeptide binding]; other site
754476000978	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476000979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000980	active site
754476000981	phosphorylation site [posttranslational modification]
754476000982	intermolecular recognition site; other site
754476000983	dimerization interface [polypeptide binding]; other site
754476000984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476000985	active site
754476000986	phosphorylation site [posttranslational modification]
754476000987	intermolecular recognition site; other site
754476000988	dimerization interface [polypeptide binding]; other site
754476000989	DJ-1 family protein; Region: not_thiJ; TIGR01383
754476000990	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
754476000991	conserved cys residue [active]
754476000992	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
754476000993	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
754476000994	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
754476000995	protein binding site [polypeptide binding]; other site
754476000996	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
754476000997	Catalytic dyad [active]
754476000998	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
754476000999	Peptidase family M23; Region: Peptidase_M23; pfam01551
754476001000	phosphoglyceromutase; Provisional; Region: PRK05434
754476001001	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
754476001002	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476001003	dimerization interface [polypeptide binding]; other site
754476001004	putative DNA binding site [nucleotide binding]; other site
754476001005	putative Zn2+ binding site [ion binding]; other site
754476001006	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
754476001007	active site residue [active]
754476001008	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
754476001009	GSH binding site [chemical binding]; other site
754476001010	catalytic residues [active]
754476001011	preprotein translocase subunit SecB; Validated; Region: PRK05751
754476001012	SecA binding site; other site
754476001013	Preprotein binding site; other site
754476001014	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
754476001015	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
754476001016	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
754476001017	Uncharacterized conserved protein [Function unknown]; Region: COG1565
754476001018	dihydromonapterin reductase; Provisional; Region: PRK06483
754476001019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476001020	NAD(P) binding site [chemical binding]; other site
754476001021	active site
754476001022	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
754476001023	homooctamer interface [polypeptide binding]; other site
754476001024	active site
754476001025	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
754476001026	UGMP family protein; Validated; Region: PRK09604
754476001027	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
754476001028	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
754476001029	Yqey-like protein; Region: YqeY; pfam09424
754476001030	DNA primase; Validated; Region: dnaG; PRK05667
754476001031	CHC2 zinc finger; Region: zf-CHC2; pfam01807
754476001032	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
754476001033	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
754476001034	active site
754476001035	metal binding site [ion binding]; metal-binding site
754476001036	interdomain interaction site; other site
754476001037	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
754476001038	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
754476001039	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
754476001040	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
754476001041	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
754476001042	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
754476001043	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476001044	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
754476001045	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476001046	DNA binding residues [nucleotide binding]
754476001047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
754476001048	active site
754476001049	DNA binding site [nucleotide binding]
754476001050	Int/Topo IB signature motif; other site
754476001051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
754476001052	sequence-specific DNA binding site [nucleotide binding]; other site
754476001053	salt bridge; other site
754476001054	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
754476001055	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
754476001056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
754476001057	LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961
754476001058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476001059	non-specific DNA binding site [nucleotide binding]; other site
754476001060	salt bridge; other site
754476001061	sequence-specific DNA binding site [nucleotide binding]; other site
754476001062	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476001063	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
754476001064	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
754476001065	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476001066	Walker A/P-loop; other site
754476001067	ATP binding site [chemical binding]; other site
754476001068	Q-loop/lid; other site
754476001069	ABC transporter signature motif; other site
754476001070	Walker B; other site
754476001071	D-loop; other site
754476001072	H-loop/switch region; other site
754476001073	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
754476001074	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476001075	Walker A/P-loop; other site
754476001076	ATP binding site [chemical binding]; other site
754476001077	Q-loop/lid; other site
754476001078	ABC transporter signature motif; other site
754476001079	Walker B; other site
754476001080	D-loop; other site
754476001081	H-loop/switch region; other site
754476001082	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476001083	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
754476001084	HlyD family secretion protein; Region: HlyD; pfam00529
754476001085	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476001086	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476001087	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
754476001088	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476001089	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476001090	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
754476001091	Putative serine esterase (DUF676); Region: DUF676; pfam05057
754476001092	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
754476001093	triosephosphate isomerase; Provisional; Region: PRK14567
754476001094	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
754476001095	substrate binding site [chemical binding]; other site
754476001096	dimer interface [polypeptide binding]; other site
754476001097	catalytic triad [active]
754476001098	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
754476001099	AMP binding site [chemical binding]; other site
754476001100	metal binding site [ion binding]; metal-binding site
754476001101	active site
754476001102	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
754476001103	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
754476001104	intersubunit interface [polypeptide binding]; other site
754476001105	active site
754476001106	zinc binding site [ion binding]; other site
754476001107	Na+ binding site [ion binding]; other site
754476001108	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
754476001109	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
754476001110	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
754476001111	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
754476001112	Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases; Region: POLO_box; cl02916
754476001113	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476001114	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
754476001115	ligand binding site [chemical binding]; other site
754476001116	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
754476001117	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
754476001118	dimer interface [polypeptide binding]; other site
754476001119	catalytic triad [active]
754476001120	peroxidatic and resolving cysteines [active]
754476001121	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
754476001122	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
754476001123	catalytic loop [active]
754476001124	iron binding site [ion binding]; other site
754476001125	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
754476001126	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
754476001127	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
754476001128	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
754476001129	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
754476001130	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
754476001131	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
754476001132	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
754476001133	XdhC Rossmann domain; Region: XdhC_C; pfam13478
754476001134	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
754476001135	Ligand binding site; other site
754476001136	metal-binding site
754476001137	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
754476001138	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
754476001139	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
754476001140	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
754476001141	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
754476001142	Na binding site [ion binding]; other site
754476001143	Outer membrane efflux protein; Region: OEP; pfam02321
754476001144	Outer membrane efflux protein; Region: OEP; pfam02321
754476001145	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
754476001146	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476001147	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
754476001148	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
754476001149	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
754476001150	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476001151	dimerization interface [polypeptide binding]; other site
754476001152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476001153	dimer interface [polypeptide binding]; other site
754476001154	phosphorylation site [posttranslational modification]
754476001155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
754476001156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001157	ATP binding site [chemical binding]; other site
754476001158	Mg2+ binding site [ion binding]; other site
754476001159	G-X-G motif; other site
754476001160	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476001161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001162	active site
754476001163	phosphorylation site [posttranslational modification]
754476001164	intermolecular recognition site; other site
754476001165	dimerization interface [polypeptide binding]; other site
754476001166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001167	Walker A motif; other site
754476001168	ATP binding site [chemical binding]; other site
754476001169	Walker B motif; other site
754476001170	arginine finger; other site
754476001171	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
754476001172	glutathione reductase; Validated; Region: PRK06116
754476001173	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
754476001174	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476001175	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
754476001176	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
754476001177	catalytic triad [active]
754476001178	dimer interface [polypeptide binding]; other site
754476001179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001180	active site
754476001181	phosphorylation site [posttranslational modification]
754476001182	intermolecular recognition site; other site
754476001183	dimerization interface [polypeptide binding]; other site
754476001184	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476001185	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476001186	GAF domain; Region: GAF; pfam01590
754476001187	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476001188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476001189	metal binding site [ion binding]; metal-binding site
754476001190	active site
754476001191	I-site; other site
754476001192	PAS domain; Region: PAS_9; pfam13426
754476001193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001194	putative active site [active]
754476001195	heme pocket [chemical binding]; other site
754476001196	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
754476001197	histidine kinase; Provisional; Region: PRK13557
754476001198	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001199	putative active site [active]
754476001200	heme pocket [chemical binding]; other site
754476001201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476001202	dimer interface [polypeptide binding]; other site
754476001203	phosphorylation site [posttranslational modification]
754476001204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001205	ATP binding site [chemical binding]; other site
754476001206	Mg2+ binding site [ion binding]; other site
754476001207	G-X-G motif; other site
754476001208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001209	active site
754476001210	phosphorylation site [posttranslational modification]
754476001211	intermolecular recognition site; other site
754476001212	dimerization interface [polypeptide binding]; other site
754476001213	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
754476001214	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
754476001215	Transcriptional regulator; Region: Rrf2; cl17282
754476001216	Predicted transcriptional regulator [Transcription]; Region: COG1959
754476001217	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
754476001218	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
754476001219	heme-binding site [chemical binding]; other site
754476001220	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
754476001221	FAD binding pocket [chemical binding]; other site
754476001222	FAD binding motif [chemical binding]; other site
754476001223	phosphate binding motif [ion binding]; other site
754476001224	beta-alpha-beta structure motif; other site
754476001225	NAD binding pocket [chemical binding]; other site
754476001226	Predicted membrane protein [Function unknown]; Region: COG3212
754476001227	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
754476001228	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476001229	HAMP domain; Region: HAMP; pfam00672
754476001230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001231	ATP binding site [chemical binding]; other site
754476001232	Mg2+ binding site [ion binding]; other site
754476001233	G-X-G motif; other site
754476001234	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476001235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001236	active site
754476001237	phosphorylation site [posttranslational modification]
754476001238	intermolecular recognition site; other site
754476001239	dimerization interface [polypeptide binding]; other site
754476001240	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476001241	DNA binding site [nucleotide binding]
754476001242	Predicted membrane protein [Function unknown]; Region: COG3212
754476001243	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
754476001244	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
754476001245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476001246	S-adenosylmethionine binding site [chemical binding]; other site
754476001247	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
754476001248	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
754476001249	tetramer interface [polypeptide binding]; other site
754476001250	heme binding pocket [chemical binding]; other site
754476001251	NADPH binding site [chemical binding]; other site
754476001252	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
754476001253	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
754476001254	dimerization interface [polypeptide binding]; other site
754476001255	DPS ferroxidase diiron center [ion binding]; other site
754476001256	ion pore; other site
754476001257	Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148
754476001258	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
754476001259	NAD(P) binding site [chemical binding]; other site
754476001260	catalytic residues [active]
754476001261	acetolactate synthase; Reviewed; Region: PRK08322
754476001262	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
754476001263	PYR/PP interface [polypeptide binding]; other site
754476001264	dimer interface [polypeptide binding]; other site
754476001265	TPP binding site [chemical binding]; other site
754476001266	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
754476001267	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
754476001268	TPP-binding site [chemical binding]; other site
754476001269	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
754476001270	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476001271	ligand binding site [chemical binding]; other site
754476001272	CHASE domain; Region: CHASE; cl01369
754476001273	PAS domain S-box; Region: sensory_box; TIGR00229
754476001274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001275	putative active site [active]
754476001276	heme pocket [chemical binding]; other site
754476001277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001278	PAS domain; Region: PAS_9; pfam13426
754476001279	putative active site [active]
754476001280	heme pocket [chemical binding]; other site
754476001281	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476001282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476001283	metal binding site [ion binding]; metal-binding site
754476001284	active site
754476001285	I-site; other site
754476001286	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476001287	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
754476001288	Na2 binding site [ion binding]; other site
754476001289	putative substrate binding site 1 [chemical binding]; other site
754476001290	Na binding site 1 [ion binding]; other site
754476001291	putative substrate binding site 2 [chemical binding]; other site
754476001292	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
754476001293	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
754476001294	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
754476001295	putative active site [active]
754476001296	putative active site [active]
754476001297	catalytic site [active]
754476001298	catalytic site [active]
754476001299	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
754476001300	putative active site [active]
754476001301	catalytic site [active]
754476001302	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
754476001303	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
754476001304	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
754476001305	putative catalytic site [active]
754476001306	putative metal binding site [ion binding]; other site
754476001307	putative phosphate binding site [ion binding]; other site
754476001308	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
754476001309	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
754476001310	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
754476001311	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476001312	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001313	Walker A motif; other site
754476001314	ATP binding site [chemical binding]; other site
754476001315	Walker B motif; other site
754476001316	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
754476001317	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
754476001318	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
754476001319	metal ion-dependent adhesion site (MIDAS); other site
754476001320	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
754476001321	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
754476001322	Low-spin heme binding site [chemical binding]; other site
754476001323	D-pathway; other site
754476001324	Putative water exit pathway; other site
754476001325	Binuclear center (active site) [active]
754476001326	K-pathway; other site
754476001327	Putative proton exit pathway; other site
754476001328	Cytochrome c; Region: Cytochrom_C; pfam00034
754476001329	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
754476001330	GAF domain; Region: GAF; pfam01590
754476001331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001332	Walker A motif; other site
754476001333	ATP binding site [chemical binding]; other site
754476001334	Walker B motif; other site
754476001335	arginine finger; other site
754476001336	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
754476001337	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
754476001338	Subunit I/III interface [polypeptide binding]; other site
754476001339	NnrS protein; Region: NnrS; pfam05940
754476001340	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
754476001341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476001342	FeS/SAM binding site; other site
754476001343	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
754476001344	DGC domain; Region: DGC; cl01742
754476001345	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
754476001346	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
754476001347	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476001348	dimerization interface [polypeptide binding]; other site
754476001349	GAF domain; Region: GAF; pfam01590
754476001350	Histidine kinase; Region: HisKA_3; pfam07730
754476001351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001352	ATP binding site [chemical binding]; other site
754476001353	Mg2+ binding site [ion binding]; other site
754476001354	G-X-G motif; other site
754476001355	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476001356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001357	active site
754476001358	phosphorylation site [posttranslational modification]
754476001359	intermolecular recognition site; other site
754476001360	dimerization interface [polypeptide binding]; other site
754476001361	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476001362	DNA binding residues [nucleotide binding]
754476001363	dimerization interface [polypeptide binding]; other site
754476001364	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
754476001365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476001366	putative substrate translocation pore; other site
754476001367	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
754476001368	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
754476001369	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
754476001370	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
754476001371	[4Fe-4S] binding site [ion binding]; other site
754476001372	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001373	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001374	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001375	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
754476001376	molybdopterin cofactor binding site; other site
754476001377	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
754476001378	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
754476001379	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
754476001380	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
754476001381	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
754476001382	active site clefts [active]
754476001383	zinc binding site [ion binding]; other site
754476001384	dimer interface [polypeptide binding]; other site
754476001385	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
754476001386	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
754476001387	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476001388	FeS/SAM binding site; other site
754476001389	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
754476001390	Predicted membrane protein [Function unknown]; Region: COG3748
754476001391	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
754476001392	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
754476001393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
754476001394	catalytic residue [active]
754476001395	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
754476001396	phosphate binding site [ion binding]; other site
754476001397	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476001398	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476001399	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476001400	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
754476001401	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
754476001402	4Fe-4S binding domain; Region: Fer4_5; pfam12801
754476001403	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
754476001404	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
754476001405	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
754476001406	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
754476001407	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
754476001408	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476001409	Walker A/P-loop; other site
754476001410	ATP binding site [chemical binding]; other site
754476001411	Q-loop/lid; other site
754476001412	ABC transporter signature motif; other site
754476001413	Walker B; other site
754476001414	D-loop; other site
754476001415	H-loop/switch region; other site
754476001416	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
754476001417	NosL; Region: NosL; pfam05573
754476001418	ATP cone domain; Region: ATP-cone; pfam03477
754476001419	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
754476001420	Class III ribonucleotide reductase; Region: RNR_III; cd01675
754476001421	effector binding site; other site
754476001422	active site
754476001423	Zn binding site [ion binding]; other site
754476001424	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
754476001425	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
754476001426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476001427	FeS/SAM binding site; other site
754476001428	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
754476001429	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
754476001430	active site
754476001431	multimer interface [polypeptide binding]; other site
754476001432	glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525
754476001433	conserved cys residue [active]
754476001434	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
754476001435	MPT binding site; other site
754476001436	trimer interface [polypeptide binding]; other site
754476001437	SCP-2 sterol transfer family; Region: SCP2; cl01225
754476001438	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
754476001439	Peptidase family U32; Region: Peptidase_U32; pfam01136
754476001440	putative protease; Provisional; Region: PRK15447
754476001441	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
754476001442	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
754476001443	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
754476001444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476001445	putative substrate translocation pore; other site
754476001446	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
754476001447	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
754476001448	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
754476001449	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
754476001450	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
754476001451	4Fe-4S binding domain; Region: Fer4; cl02805
754476001452	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
754476001453	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
754476001454	[4Fe-4S] binding site [ion binding]; other site
754476001455	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001456	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001457	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476001458	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
754476001459	molybdopterin cofactor binding site; other site
754476001460	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
754476001461	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
754476001462	metal ion-dependent adhesion site (MIDAS); other site
754476001463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001464	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476001465	Walker A motif; other site
754476001466	ATP binding site [chemical binding]; other site
754476001467	Walker B motif; other site
754476001468	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
754476001469	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
754476001470	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
754476001471	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
754476001472	Binuclear center (active site) [active]
754476001473	K-pathway; other site
754476001474	Putative proton exit pathway; other site
754476001475	Putative water exit pathway; other site
754476001476	Cytochrome c; Region: Cytochrom_C; pfam00034
754476001477	Cytochrome c; Region: Cytochrom_C; cl11414
754476001478	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
754476001479	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476001480	FeS/SAM binding site; other site
754476001481	HemN C-terminal domain; Region: HemN_C; pfam06969
754476001482	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
754476001483	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
754476001484	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
754476001485	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
754476001486	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
754476001487	phosphoribulokinase; Provisional; Region: PRK15453
754476001488	active site
754476001489	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
754476001490	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
754476001491	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
754476001492	peptide chain release factor 1; Validated; Region: prfA; PRK00591
754476001493	This domain is found in peptide chain release factors; Region: PCRF; smart00937
754476001494	RF-1 domain; Region: RF-1; pfam00472
754476001495	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
754476001496	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
754476001497	tRNA; other site
754476001498	putative tRNA binding site [nucleotide binding]; other site
754476001499	putative NADP binding site [chemical binding]; other site
754476001500	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
754476001501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476001502	TPR motif; other site
754476001503	binding surface
754476001504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476001505	binding surface
754476001506	TPR motif; other site
754476001507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
754476001508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476001509	binding surface
754476001510	TPR motif; other site
754476001511	TPR repeat; Region: TPR_11; pfam13414
754476001512	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
754476001513	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
754476001514	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
754476001515	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
754476001516	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
754476001517	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
754476001518	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
754476001519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476001520	active site
754476001521	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
754476001522	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
754476001523	5S rRNA interface [nucleotide binding]; other site
754476001524	CTC domain interface [polypeptide binding]; other site
754476001525	L16 interface [polypeptide binding]; other site
754476001526	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
754476001527	putative active site [active]
754476001528	catalytic residue [active]
754476001529	GTP-binding protein YchF; Reviewed; Region: PRK09601
754476001530	YchF GTPase; Region: YchF; cd01900
754476001531	G1 box; other site
754476001532	GTP/Mg2+ binding site [chemical binding]; other site
754476001533	Switch I region; other site
754476001534	G2 box; other site
754476001535	Switch II region; other site
754476001536	G3 box; other site
754476001537	G4 box; other site
754476001538	G5 box; other site
754476001539	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
754476001540	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
754476001541	dimerization interface [polypeptide binding]; other site
754476001542	substrate binding site [chemical binding]; other site
754476001543	active site
754476001544	calcium binding site [ion binding]; other site
754476001545	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
754476001546	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476001547	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476001548	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476001549	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476001550	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
754476001551	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
754476001552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476001553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476001554	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
754476001555	putative dimerization interface [polypeptide binding]; other site
754476001556	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
754476001557	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
754476001558	dimer interface [polypeptide binding]; other site
754476001559	catalytic residue [active]
754476001560	metal binding site [ion binding]; metal-binding site
754476001561	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
754476001562	multimerization interface [polypeptide binding]; other site
754476001563	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476001564	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
754476001565	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
754476001566	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
754476001567	metal ion-dependent adhesion site (MIDAS); other site
754476001568	NMT1/THI5 like; Region: NMT1; pfam09084
754476001569	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
754476001570	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
754476001571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476001572	substrate binding pocket [chemical binding]; other site
754476001573	membrane-bound complex binding site; other site
754476001574	hinge residues; other site
754476001575	PAS domain S-box; Region: sensory_box; TIGR00229
754476001576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001577	PAS domain; Region: PAS_9; pfam13426
754476001578	putative active site [active]
754476001579	heme pocket [chemical binding]; other site
754476001580	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476001581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476001582	metal binding site [ion binding]; metal-binding site
754476001583	active site
754476001584	I-site; other site
754476001585	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476001586	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
754476001587	metal ion-dependent adhesion site (MIDAS); other site
754476001588	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
754476001589	metal ion-dependent adhesion site (MIDAS); other site
754476001590	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
754476001591	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476001592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001593	Walker A motif; other site
754476001594	ATP binding site [chemical binding]; other site
754476001595	Walker B motif; other site
754476001596	arginine finger; other site
754476001597	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
754476001598	cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872
754476001599	methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870
754476001600	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476001601	substrate binding pocket [chemical binding]; other site
754476001602	membrane-bound complex binding site; other site
754476001603	hinge residues; other site
754476001604	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476001605	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
754476001606	Trp docking motif [polypeptide binding]; other site
754476001607	dimer interface [polypeptide binding]; other site
754476001608	active site
754476001609	small subunit binding site [polypeptide binding]; other site
754476001610	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476001611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001612	active site
754476001613	phosphorylation site [posttranslational modification]
754476001614	intermolecular recognition site; other site
754476001615	dimerization interface [polypeptide binding]; other site
754476001616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476001617	DNA binding residues [nucleotide binding]
754476001618	dimerization interface [polypeptide binding]; other site
754476001619	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476001620	Histidine kinase; Region: HisKA_3; pfam07730
754476001621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001622	ATP binding site [chemical binding]; other site
754476001623	Mg2+ binding site [ion binding]; other site
754476001624	G-X-G motif; other site
754476001625	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
754476001626	putative hydrophobic ligand binding site [chemical binding]; other site
754476001627	protein interface [polypeptide binding]; other site
754476001628	gate; other site
754476001629	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
754476001630	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476001631	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476001632	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476001633	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476001634	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476001635	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
754476001636	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
754476001637	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476001638	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476001639	catalytic residue [active]
754476001640	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476001641	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476001642	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476001643	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
754476001644	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
754476001645	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
754476001646	quinone interaction residues [chemical binding]; other site
754476001647	active site
754476001648	catalytic residues [active]
754476001649	FMN binding site [chemical binding]; other site
754476001650	substrate binding site [chemical binding]; other site
754476001651	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476001652	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
754476001653	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476001654	Methyltransferase domain; Region: Methyltransf_11; pfam08241
754476001655	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
754476001656	RNA/DNA hybrid binding site [nucleotide binding]; other site
754476001657	active site
754476001658	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
754476001659	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
754476001660	active site
754476001661	catalytic site [active]
754476001662	substrate binding site [chemical binding]; other site
754476001663	GrpE; Region: GrpE; pfam01025
754476001664	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
754476001665	dimer interface [polypeptide binding]; other site
754476001666	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
754476001667	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
754476001668	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
754476001669	nucleotide binding site [chemical binding]; other site
754476001670	chaperone protein DnaJ; Provisional; Region: PRK10767
754476001671	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
754476001672	HSP70 interaction site [polypeptide binding]; other site
754476001673	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
754476001674	substrate binding site [polypeptide binding]; other site
754476001675	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
754476001676	Zn binding sites [ion binding]; other site
754476001677	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
754476001678	dimer interface [polypeptide binding]; other site
754476001679	dihydrodipicolinate reductase; Provisional; Region: PRK00048
754476001680	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
754476001681	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
754476001682	TPR repeat; Region: TPR_11; pfam13414
754476001683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476001684	binding surface
754476001685	TPR motif; other site
754476001686	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
754476001687	Transglycosylase; Region: Transgly; pfam00912
754476001688	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
754476001689	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
754476001690	Peptidase family M48; Region: Peptidase_M48; cl12018
754476001691	Peptidase family M48; Region: Peptidase_M48; cl12018
754476001692	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
754476001693	putative catalytic residue [active]
754476001694	transketolase; Reviewed; Region: PRK12753
754476001695	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
754476001696	TPP-binding site [chemical binding]; other site
754476001697	dimer interface [polypeptide binding]; other site
754476001698	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
754476001699	PYR/PP interface [polypeptide binding]; other site
754476001700	dimer interface [polypeptide binding]; other site
754476001701	TPP binding site [chemical binding]; other site
754476001702	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
754476001703	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
754476001704	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
754476001705	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
754476001706	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
754476001707	Phosphoglycerate kinase; Region: PGK; pfam00162
754476001708	substrate binding site [chemical binding]; other site
754476001709	hinge regions; other site
754476001710	ADP binding site [chemical binding]; other site
754476001711	catalytic site [active]
754476001712	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
754476001713	pyruvate kinase; Provisional; Region: PRK05826
754476001714	domain interfaces; other site
754476001715	active site
754476001716	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
754476001717	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
754476001718	intersubunit interface [polypeptide binding]; other site
754476001719	active site
754476001720	zinc binding site [ion binding]; other site
754476001721	Na+ binding site [ion binding]; other site
754476001722	CrcB-like protein; Region: CRCB; cl09114
754476001723	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
754476001724	seryl-tRNA synthetase; Provisional; Region: PRK05431
754476001725	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
754476001726	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
754476001727	dimer interface [polypeptide binding]; other site
754476001728	active site
754476001729	motif 1; other site
754476001730	motif 2; other site
754476001731	motif 3; other site
754476001732	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
754476001733	Peptidase family M50; Region: Peptidase_M50; pfam02163
754476001734	active site
754476001735	putative substrate binding region [chemical binding]; other site
754476001736	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
754476001737	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
754476001738	active site
754476001739	HIGH motif; other site
754476001740	dimer interface [polypeptide binding]; other site
754476001741	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
754476001742	active site
754476001743	KMSKS motif; other site
754476001744	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
754476001745	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476001746	RNA binding surface [nucleotide binding]; other site
754476001747	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
754476001748	probable active site [active]
754476001749	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476001750	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476001751	metal binding site [ion binding]; metal-binding site
754476001752	active site
754476001753	I-site; other site
754476001754	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
754476001755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476001756	NAD(P) binding site [chemical binding]; other site
754476001757	active site
754476001758	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
754476001759	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
754476001760	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
754476001761	active site lid residues [active]
754476001762	substrate binding pocket [chemical binding]; other site
754476001763	catalytic residues [active]
754476001764	substrate-Mg2+ binding site; other site
754476001765	aspartate-rich region 1; other site
754476001766	aspartate-rich region 2; other site
754476001767	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
754476001768	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
754476001769	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
754476001770	substrate binding pocket [chemical binding]; other site
754476001771	chain length determination region; other site
754476001772	substrate-Mg2+ binding site; other site
754476001773	catalytic residues [active]
754476001774	aspartate-rich region 1; other site
754476001775	active site lid residues [active]
754476001776	aspartate-rich region 2; other site
754476001777	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
754476001778	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
754476001779	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
754476001780	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
754476001781	GTP1/OBG; Region: GTP1_OBG; pfam01018
754476001782	Obg GTPase; Region: Obg; cd01898
754476001783	G1 box; other site
754476001784	GTP/Mg2+ binding site [chemical binding]; other site
754476001785	Switch I region; other site
754476001786	G2 box; other site
754476001787	G3 box; other site
754476001788	Switch II region; other site
754476001789	G4 box; other site
754476001790	G5 box; other site
754476001791	gamma-glutamyl kinase; Provisional; Region: PRK05429
754476001792	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
754476001793	nucleotide binding site [chemical binding]; other site
754476001794	homotetrameric interface [polypeptide binding]; other site
754476001795	putative phosphate binding site [ion binding]; other site
754476001796	putative allosteric binding site; other site
754476001797	PUA domain; Region: PUA; pfam01472
754476001798	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
754476001799	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
754476001800	putative active site [active]
754476001801	putative catalytic site [active]
754476001802	putative DNA binding site [nucleotide binding]; other site
754476001803	putative phosphate binding site [ion binding]; other site
754476001804	metal binding site A [ion binding]; metal-binding site
754476001805	putative AP binding site [nucleotide binding]; other site
754476001806	putative metal binding site B [ion binding]; other site
754476001807	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
754476001808	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476001809	ATP binding site [chemical binding]; other site
754476001810	putative Mg++ binding site [ion binding]; other site
754476001811	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476001812	nucleotide binding region [chemical binding]; other site
754476001813	ATP-binding site [chemical binding]; other site
754476001814	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
754476001815	HRDC domain; Region: HRDC; pfam00570
754476001816	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
754476001817	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
754476001818	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476001819	non-specific DNA binding site [nucleotide binding]; other site
754476001820	salt bridge; other site
754476001821	sequence-specific DNA binding site [nucleotide binding]; other site
754476001822	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
754476001823	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
754476001824	active site
754476001825	DNA polymerase IV; Validated; Region: PRK02406
754476001826	DNA binding site [nucleotide binding]
754476001827	muropeptide transporter; Validated; Region: ampG; cl17669
754476001828	muropeptide transporter; Validated; Region: ampG; cl17669
754476001829	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
754476001830	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
754476001831	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
754476001832	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
754476001833	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
754476001834	dimer interface [polypeptide binding]; other site
754476001835	ssDNA binding site [nucleotide binding]; other site
754476001836	tetramer (dimer of dimers) interface [polypeptide binding]; other site
754476001837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476001838	Major Facilitator Superfamily; Region: MFS_1; pfam07690
754476001839	putative substrate translocation pore; other site
754476001840	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
754476001841	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
754476001842	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
754476001843	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
754476001844	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
754476001845	putative active site [active]
754476001846	putative metal binding residues [ion binding]; other site
754476001847	signature motif; other site
754476001848	putative triphosphate binding site [ion binding]; other site
754476001849	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476001850	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
754476001851	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
754476001852	ApbE family; Region: ApbE; pfam02424
754476001853	glutathione synthetase; Provisional; Region: PRK05246
754476001854	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
754476001855	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
754476001856	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
754476001857	dimer interface [polypeptide binding]; other site
754476001858	motif 1; other site
754476001859	active site
754476001860	motif 2; other site
754476001861	motif 3; other site
754476001862	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
754476001863	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
754476001864	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
754476001865	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476001866	active site
754476001867	motif I; other site
754476001868	motif II; other site
754476001869	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
754476001870	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
754476001871	putative acyl-acceptor binding pocket; other site
754476001872	Response regulator receiver domain; Region: Response_reg; pfam00072
754476001873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001874	active site
754476001875	phosphorylation site [posttranslational modification]
754476001876	intermolecular recognition site; other site
754476001877	dimerization interface [polypeptide binding]; other site
754476001878	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476001879	putative active site [active]
754476001880	heme pocket [chemical binding]; other site
754476001881	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476001882	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476001883	metal binding site [ion binding]; metal-binding site
754476001884	active site
754476001885	I-site; other site
754476001886	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476001887	heat shock protein HtpX; Provisional; Region: PRK05457
754476001888	ATP-grasp domain; Region: ATP-grasp_4; cl17255
754476001889	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
754476001890	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
754476001891	NADP binding site [chemical binding]; other site
754476001892	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
754476001893	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
754476001894	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
754476001895	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
754476001896	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
754476001897	NADP binding site [chemical binding]; other site
754476001898	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
754476001899	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
754476001900	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
754476001901	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
754476001902	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
754476001903	active site
754476001904	HIGH motif; other site
754476001905	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
754476001906	active site
754476001907	KMSKS motif; other site
754476001908	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476001909	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
754476001910	Trp docking motif [polypeptide binding]; other site
754476001911	dimer interface [polypeptide binding]; other site
754476001912	active site
754476001913	small subunit binding site [polypeptide binding]; other site
754476001914	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
754476001915	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
754476001916	substrate binding pocket [chemical binding]; other site
754476001917	membrane-bound complex binding site; other site
754476001918	hinge residues; other site
754476001919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476001920	dimerization interface [polypeptide binding]; other site
754476001921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476001922	dimer interface [polypeptide binding]; other site
754476001923	phosphorylation site [posttranslational modification]
754476001924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476001925	ATP binding site [chemical binding]; other site
754476001926	Mg2+ binding site [ion binding]; other site
754476001927	G-X-G motif; other site
754476001928	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476001929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476001930	active site
754476001931	phosphorylation site [posttranslational modification]
754476001932	intermolecular recognition site; other site
754476001933	dimerization interface [polypeptide binding]; other site
754476001934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476001935	Walker A motif; other site
754476001936	ATP binding site [chemical binding]; other site
754476001937	Walker B motif; other site
754476001938	arginine finger; other site
754476001939	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476001940	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
754476001941	stringent starvation protein A; Provisional; Region: sspA; PRK09481
754476001942	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
754476001943	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
754476001944	dimer interface [polypeptide binding]; other site
754476001945	N-terminal domain interface [polypeptide binding]; other site
754476001946	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
754476001947	cytochrome b; Provisional; Region: CYTB; MTH00145
754476001948	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
754476001949	Qi binding site; other site
754476001950	intrachain domain interface; other site
754476001951	interchain domain interface [polypeptide binding]; other site
754476001952	heme bH binding site [chemical binding]; other site
754476001953	heme bL binding site [chemical binding]; other site
754476001954	Qo binding site; other site
754476001955	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
754476001956	interchain domain interface [polypeptide binding]; other site
754476001957	intrachain domain interface; other site
754476001958	Qi binding site; other site
754476001959	Qo binding site; other site
754476001960	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
754476001961	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
754476001962	[2Fe-2S] cluster binding site [ion binding]; other site
754476001963	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
754476001964	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
754476001965	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
754476001966	Uncharacterized conserved protein [Function unknown]; Region: COG2928
754476001967	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
754476001968	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
754476001969	dimer interface [polypeptide binding]; other site
754476001970	anticodon binding site; other site
754476001971	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
754476001972	homodimer interface [polypeptide binding]; other site
754476001973	motif 1; other site
754476001974	active site
754476001975	motif 2; other site
754476001976	GAD domain; Region: GAD; pfam02938
754476001977	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
754476001978	motif 3; other site
754476001979	quinolinate synthetase; Provisional; Region: PRK09375
754476001980	Zinc-finger domain; Region: zf-CHCC; cl01821
754476001981	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
754476001982	active site
754476001983	8-oxo-dGMP binding site [chemical binding]; other site
754476001984	nudix motif; other site
754476001985	metal binding site [ion binding]; metal-binding site
754476001986	Domain of unknown function (DUF329); Region: DUF329; pfam03884
754476001987	hypothetical protein; Provisional; Region: PRK05287
754476001988	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
754476001989	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
754476001990	CoA-binding site [chemical binding]; other site
754476001991	ATP-binding [chemical binding]; other site
754476001992	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
754476001993	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
754476001994	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
754476001995	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
754476001996	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476001997	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476001998	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
754476001999	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
754476002000	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
754476002001	Walker A motif; other site
754476002002	ATP binding site [chemical binding]; other site
754476002003	Walker B motif; other site
754476002004	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
754476002005	diaminopimelate decarboxylase; Region: lysA; TIGR01048
754476002006	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
754476002007	active site
754476002008	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
754476002009	substrate binding site [chemical binding]; other site
754476002010	catalytic residues [active]
754476002011	dimer interface [polypeptide binding]; other site
754476002012	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
754476002013	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
754476002014	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
754476002015	Protein of unknown function, DUF484; Region: DUF484; cl17449
754476002016	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
754476002017	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
754476002018	active site
754476002019	Int/Topo IB signature motif; other site
754476002020	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
754476002021	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476002022	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476002023	Transposase; Region: DEDD_Tnp_IS110; pfam01548
754476002024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
754476002025	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
754476002026	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
754476002027	DNA photolyase; Region: DNA_photolyase; pfam00875
754476002028	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
754476002029	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
754476002030	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
754476002031	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
754476002032	active site
754476002033	catalytic site [active]
754476002034	substrate binding site [chemical binding]; other site
754476002035	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
754476002036	GIY-YIG motif/motif A; other site
754476002037	active site
754476002038	catalytic site [active]
754476002039	putative DNA binding site [nucleotide binding]; other site
754476002040	metal binding site [ion binding]; metal-binding site
754476002041	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476002042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476002043	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
754476002044	catalytic site [active]
754476002045	putative active site [active]
754476002046	putative substrate binding site [chemical binding]; other site
754476002047	dimer interface [polypeptide binding]; other site
754476002048	Peptidase family M48; Region: Peptidase_M48; pfam01435
754476002049	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476002050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476002051	metal binding site [ion binding]; metal-binding site
754476002052	active site
754476002053	I-site; other site
754476002054	2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633
754476002055	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
754476002056	Ligand Binding Site [chemical binding]; other site
754476002057	thioredoxin reductase; Provisional; Region: PRK10262
754476002058	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
754476002059	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476002060	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
754476002061	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
754476002062	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
754476002063	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
754476002064	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
754476002065	recombination factor protein RarA; Reviewed; Region: PRK13342
754476002066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476002067	Walker A motif; other site
754476002068	ATP binding site [chemical binding]; other site
754476002069	Walker B motif; other site
754476002070	arginine finger; other site
754476002071	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
754476002072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002073	S-adenosylmethionine binding site [chemical binding]; other site
754476002074	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002075	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
754476002076	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002077	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002078	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002079	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002080	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476002081	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
754476002082	putative hydrophobic ligand binding site [chemical binding]; other site
754476002083	protein interface [polypeptide binding]; other site
754476002084	gate; other site
754476002085	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
754476002086	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
754476002087	Walker A/P-loop; other site
754476002088	ATP binding site [chemical binding]; other site
754476002089	Q-loop/lid; other site
754476002090	ABC transporter signature motif; other site
754476002091	Walker B; other site
754476002092	D-loop; other site
754476002093	H-loop/switch region; other site
754476002094	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
754476002095	Permease; Region: Permease; cl00510
754476002096	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
754476002097	mce related protein; Region: MCE; pfam02470
754476002098	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
754476002099	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
754476002100	anti sigma factor interaction site; other site
754476002101	regulatory phosphorylation site [posttranslational modification]; other site
754476002102	BolA-like protein; Region: BolA; pfam01722
754476002103	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
754476002104	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
754476002105	hinge; other site
754476002106	active site
754476002107	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
754476002108	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
754476002109	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
754476002110	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
754476002111	NAD binding site [chemical binding]; other site
754476002112	dimerization interface [polypeptide binding]; other site
754476002113	product binding site; other site
754476002114	substrate binding site [chemical binding]; other site
754476002115	zinc binding site [ion binding]; other site
754476002116	catalytic residues [active]
754476002117	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
754476002118	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476002119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476002120	homodimer interface [polypeptide binding]; other site
754476002121	catalytic residue [active]
754476002122	hypothetical protein; Provisional; Region: PRK10621
754476002123	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
754476002124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476002125	active site
754476002126	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476002127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002128	S-adenosylmethionine binding site [chemical binding]; other site
754476002129	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
754476002130	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
754476002131	YGGT family; Region: YGGT; pfam02325
754476002132	YGGT family; Region: YGGT; pfam02325
754476002133	pyrroline-5-carboxylate reductase; Region: PLN02688
754476002134	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
754476002135	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
754476002136	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
754476002137	catalytic residue [active]
754476002138	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
754476002139	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
754476002140	Walker A motif; other site
754476002141	ATP binding site [chemical binding]; other site
754476002142	Walker B motif; other site
754476002143	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
754476002144	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
754476002145	Walker A motif; other site
754476002146	ATP binding site [chemical binding]; other site
754476002147	Walker B motif; other site
754476002148	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
754476002149	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476002150	ligand binding site [chemical binding]; other site
754476002151	CsbD-like; Region: CsbD; cl17424
754476002152	BON domain; Region: BON; pfam04972
754476002153	BON domain; Region: BON; pfam04972
754476002154	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
754476002155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476002156	Walker A motif; other site
754476002157	ATP binding site [chemical binding]; other site
754476002158	Walker B motif; other site
754476002159	arginine finger; other site
754476002160	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476002161	HipA N-terminal domain; Region: Couple_hipA; pfam13657
754476002162	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
754476002163	HipA-like N-terminal domain; Region: HipA_N; pfam07805
754476002164	HipA-like C-terminal domain; Region: HipA_C; pfam07804
754476002165	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
754476002166	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476002167	non-specific DNA binding site [nucleotide binding]; other site
754476002168	salt bridge; other site
754476002169	sequence-specific DNA binding site [nucleotide binding]; other site
754476002170	HTH-like domain; Region: HTH_21; pfam13276
754476002171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
754476002172	Integrase core domain; Region: rve; pfam00665
754476002173	Uncharacterized conserved protein [Function unknown]; Region: COG0398
754476002174	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
754476002175	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
754476002176	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476002177	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
754476002178	putative ADP-binding pocket [chemical binding]; other site
754476002179	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476002180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002181	active site
754476002182	phosphorylation site [posttranslational modification]
754476002183	intermolecular recognition site; other site
754476002184	dimerization interface [polypeptide binding]; other site
754476002185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476002186	DNA binding site [nucleotide binding]
754476002187	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476002188	HAMP domain; Region: HAMP; pfam00672
754476002189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476002190	dimer interface [polypeptide binding]; other site
754476002191	phosphorylation site [posttranslational modification]
754476002192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002193	ATP binding site [chemical binding]; other site
754476002194	Mg2+ binding site [ion binding]; other site
754476002195	G-X-G motif; other site
754476002196	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
754476002197	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
754476002198	Sulfatase; Region: Sulfatase; pfam00884
754476002199	Bacitracin resistance protein BacA; Region: BacA; pfam02673
754476002200	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
754476002201	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
754476002202	Transposase; Region: HTH_Tnp_1; pfam01527
754476002203	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
754476002204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
754476002205	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
754476002206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
754476002207	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
754476002208	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
754476002209	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
754476002210	HipA N-terminal domain; Region: Couple_hipA; pfam13657
754476002211	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
754476002212	HipA-like N-terminal domain; Region: HipA_N; pfam07805
754476002213	HipA-like C-terminal domain; Region: HipA_C; pfam07804
754476002214	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
754476002215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476002216	non-specific DNA binding site [nucleotide binding]; other site
754476002217	salt bridge; other site
754476002218	sequence-specific DNA binding site [nucleotide binding]; other site
754476002219	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
754476002220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
754476002221	ATP binding site [chemical binding]; other site
754476002222	Mg2+ binding site [ion binding]; other site
754476002223	G-X-G motif; other site
754476002224	MarR family; Region: MarR_2; cl17246
754476002225	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
754476002226	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
754476002227	ThiF family; Region: ThiF; pfam00899
754476002228	ATP binding site [chemical binding]; other site
754476002229	substrate interface [chemical binding]; other site
754476002230	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
754476002231	active site
754476002232	catalytic residues [active]
754476002233	DNA binding site [nucleotide binding]
754476002234	Int/Topo IB signature motif; other site
754476002235	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
754476002236	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
754476002237	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
754476002238	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
754476002239	active site
754476002240	DNA binding site [nucleotide binding]
754476002241	Int/Topo IB signature motif; other site
754476002242	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
754476002243	DEAD-like helicases superfamily; Region: DEXDc; smart00487
754476002244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476002245	ATP binding site [chemical binding]; other site
754476002246	putative Mg++ binding site [ion binding]; other site
754476002247	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
754476002248	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
754476002249	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
754476002250	AAA domain; Region: AAA_21; pfam13304
754476002251	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476002252	ABC transporter signature motif; other site
754476002253	Walker B; other site
754476002254	D-loop; other site
754476002255	H-loop/switch region; other site
754476002256	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
754476002257	Methyltransferase domain; Region: Methyltransf_26; pfam13659
754476002258	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
754476002259	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
754476002260	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
754476002261	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
754476002262	HerA helicase [Replication, recombination, and repair]; Region: COG0433
754476002263	Domain of unknown function DUF87; Region: DUF87; pfam01935
754476002264	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
754476002265	homodimer interface [polypeptide binding]; other site
754476002266	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
754476002267	active site pocket [active]
754476002268	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
754476002269	G1 box; other site
754476002270	GTP/Mg2+ binding site [chemical binding]; other site
754476002271	Switch I region; other site
754476002272	G2 box; other site
754476002273	G3 box; other site
754476002274	Switch II region; other site
754476002275	G4 box; other site
754476002276	G5 box; other site
754476002277	Cytochrome c553 [Energy production and conversion]; Region: COG2863
754476002278	Cytochrome c; Region: Cytochrom_C; cl11414
754476002279	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
754476002280	ResB-like family; Region: ResB; pfam05140
754476002281	ResB-like family; Region: ResB; pfam05140
754476002282	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
754476002283	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
754476002284	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
754476002285	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
754476002286	catalytic residues [active]
754476002287	hinge region; other site
754476002288	alpha helical domain; other site
754476002289	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
754476002290	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476002291	substrate binding pocket [chemical binding]; other site
754476002292	membrane-bound complex binding site; other site
754476002293	hinge residues; other site
754476002294	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476002295	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476002296	catalytic residue [active]
754476002297	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
754476002298	nucleoside/Zn binding site; other site
754476002299	dimer interface [polypeptide binding]; other site
754476002300	catalytic motif [active]
754476002301	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
754476002302	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
754476002303	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
754476002304	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
754476002305	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
754476002306	putative acyl-acceptor binding pocket; other site
754476002307	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
754476002308	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
754476002309	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
754476002310	23S rRNA interface [nucleotide binding]; other site
754476002311	L3 interface [polypeptide binding]; other site
754476002312	Bacitracin resistance protein BacA; Region: BacA; pfam02673
754476002313	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
754476002314	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
754476002315	FAD binding domain; Region: FAD_binding_4; pfam01565
754476002316	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
754476002317	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
754476002318	Cysteine-rich domain; Region: CCG; pfam02754
754476002319	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
754476002320	HopJ type III effector protein; Region: HopJ; pfam08888
754476002321	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
754476002322	putative FMN binding site [chemical binding]; other site
754476002323	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
754476002324	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
754476002325	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
754476002326	GTP/Mg2+ binding site [chemical binding]; other site
754476002327	G4 box; other site
754476002328	G5 box; other site
754476002329	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
754476002330	G1 box; other site
754476002331	G1 box; other site
754476002332	GTP/Mg2+ binding site [chemical binding]; other site
754476002333	Switch I region; other site
754476002334	G2 box; other site
754476002335	G2 box; other site
754476002336	Switch I region; other site
754476002337	G3 box; other site
754476002338	G3 box; other site
754476002339	Switch II region; other site
754476002340	Switch II region; other site
754476002341	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
754476002342	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
754476002343	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
754476002344	active site
754476002345	NTP binding site [chemical binding]; other site
754476002346	metal binding triad [ion binding]; metal-binding site
754476002347	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
754476002348	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
754476002349	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
754476002350	SdiA-regulated; Region: SdiA-regulated; cd09971
754476002351	SdiA-regulated; Region: SdiA-regulated; pfam06977
754476002352	putative active site [active]
754476002353	Acylphosphatase; Region: Acylphosphatase; pfam00708
754476002354	HD domain; Region: HD_4; pfam13328
754476002355	GMP synthase; Reviewed; Region: guaA; PRK00074
754476002356	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
754476002357	AMP/PPi binding site [chemical binding]; other site
754476002358	candidate oxyanion hole; other site
754476002359	catalytic triad [active]
754476002360	potential glutamine specificity residues [chemical binding]; other site
754476002361	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
754476002362	ATP Binding subdomain [chemical binding]; other site
754476002363	Ligand Binding sites [chemical binding]; other site
754476002364	Dimerization subdomain; other site
754476002365	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
754476002366	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
754476002367	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
754476002368	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
754476002369	active site
754476002370	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
754476002371	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
754476002372	generic binding surface II; other site
754476002373	generic binding surface I; other site
754476002374	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
754476002375	Peptidase family M23; Region: Peptidase_M23; pfam01551
754476002376	NMT1/THI5 like; Region: NMT1; pfam09084
754476002377	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
754476002378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476002379	putative active site [active]
754476002380	heme pocket [chemical binding]; other site
754476002381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476002382	dimer interface [polypeptide binding]; other site
754476002383	phosphorylation site [posttranslational modification]
754476002384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002385	ATP binding site [chemical binding]; other site
754476002386	Mg2+ binding site [ion binding]; other site
754476002387	G-X-G motif; other site
754476002388	Response regulator receiver domain; Region: Response_reg; pfam00072
754476002389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002390	active site
754476002391	phosphorylation site [posttranslational modification]
754476002392	intermolecular recognition site; other site
754476002393	dimerization interface [polypeptide binding]; other site
754476002394	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
754476002395	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
754476002396	Walker A/P-loop; other site
754476002397	ATP binding site [chemical binding]; other site
754476002398	Q-loop/lid; other site
754476002399	ABC transporter signature motif; other site
754476002400	Walker B; other site
754476002401	D-loop; other site
754476002402	H-loop/switch region; other site
754476002403	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
754476002404	OstA-like protein; Region: OstA; pfam03968
754476002405	Bacterial SH3 domain; Region: SH3_3; pfam08239
754476002406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
754476002407	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
754476002408	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
754476002409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476002410	active site
754476002411	motif I; other site
754476002412	motif II; other site
754476002413	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
754476002414	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
754476002415	putative active site [active]
754476002416	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
754476002417	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
754476002418	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476002419	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476002420	VacJ like lipoprotein; Region: VacJ; cl01073
754476002421	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476002422	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
754476002423	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
754476002424	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
754476002425	putative active site [active]
754476002426	putative metal binding site [ion binding]; other site
754476002427	oligopeptidase A; Provisional; Region: PRK10911
754476002428	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
754476002429	active site
754476002430	Zn binding site [ion binding]; other site
754476002431	hypothetical protein; Provisional; Region: PRK11019
754476002432	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
754476002433	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
754476002434	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
754476002435	MAPEG family; Region: MAPEG; cl09190
754476002436	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
754476002437	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
754476002438	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
754476002439	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
754476002440	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
754476002441	catalytic loop [active]
754476002442	iron binding site [ion binding]; other site
754476002443	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
754476002444	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
754476002445	[4Fe-4S] binding site [ion binding]; other site
754476002446	molybdopterin cofactor binding site; other site
754476002447	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
754476002448	molybdopterin cofactor binding site; other site
754476002449	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
754476002450	putative dimer interface [polypeptide binding]; other site
754476002451	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
754476002452	SLBB domain; Region: SLBB; pfam10531
754476002453	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
754476002454	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
754476002455	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
754476002456	putative dimer interface [polypeptide binding]; other site
754476002457	[2Fe-2S] cluster binding site [ion binding]; other site
754476002458	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
754476002459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476002460	PBP superfamily domain; Region: PBP_like; pfam12727
754476002461	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
754476002462	MoaE homodimer interface [polypeptide binding]; other site
754476002463	MoaD interaction [polypeptide binding]; other site
754476002464	active site residues [active]
754476002465	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
754476002466	MoaE interaction surface [polypeptide binding]; other site
754476002467	MoeB interaction surface [polypeptide binding]; other site
754476002468	thiocarboxylated glycine; other site
754476002469	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
754476002470	trimer interface [polypeptide binding]; other site
754476002471	dimer interface [polypeptide binding]; other site
754476002472	putative active site [active]
754476002473	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
754476002474	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
754476002475	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
754476002476	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
754476002477	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
754476002478	PBP superfamily domain; Region: PBP_like_2; pfam12849
754476002479	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
754476002480	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
754476002481	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476002482	Walker A/P-loop; other site
754476002483	ATP binding site [chemical binding]; other site
754476002484	Q-loop/lid; other site
754476002485	ABC transporter signature motif; other site
754476002486	Walker B; other site
754476002487	D-loop; other site
754476002488	H-loop/switch region; other site
754476002489	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
754476002490	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
754476002491	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
754476002492	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
754476002493	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476002494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002495	active site
754476002496	phosphorylation site [posttranslational modification]
754476002497	intermolecular recognition site; other site
754476002498	dimerization interface [polypeptide binding]; other site
754476002499	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
754476002500	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
754476002501	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
754476002502	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
754476002503	FlgN protein; Region: FlgN; pfam05130
754476002504	ferrochelatase; Reviewed; Region: hemH; PRK00035
754476002505	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
754476002506	C-terminal domain interface [polypeptide binding]; other site
754476002507	active site
754476002508	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
754476002509	active site
754476002510	N-terminal domain interface [polypeptide binding]; other site
754476002511	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
754476002512	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
754476002513	putative NAD(P) binding site [chemical binding]; other site
754476002514	putative active site [active]
754476002515	Protein of unknown function (DUF523); Region: DUF523; pfam04463
754476002516	Uncharacterized conserved protein [Function unknown]; Region: COG3272
754476002517	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
754476002518	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
754476002519	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
754476002520	active site
754476002521	Zn binding site [ion binding]; other site
754476002522	enoyl-CoA hydratase; Validated; Region: PRK08788
754476002523	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
754476002524	substrate binding site [chemical binding]; other site
754476002525	oxyanion hole (OAH) forming residues; other site
754476002526	trimer interface [polypeptide binding]; other site
754476002527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476002528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476002529	dimer interface [polypeptide binding]; other site
754476002530	phosphorylation site [posttranslational modification]
754476002531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002532	ATP binding site [chemical binding]; other site
754476002533	Mg2+ binding site [ion binding]; other site
754476002534	G-X-G motif; other site
754476002535	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476002536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002537	active site
754476002538	phosphorylation site [posttranslational modification]
754476002539	intermolecular recognition site; other site
754476002540	dimerization interface [polypeptide binding]; other site
754476002541	Hpt domain; Region: Hpt; pfam01627
754476002542	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
754476002543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002544	active site
754476002545	phosphorylation site [posttranslational modification]
754476002546	intermolecular recognition site; other site
754476002547	dimerization interface [polypeptide binding]; other site
754476002548	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476002549	Zn2+ binding site [ion binding]; other site
754476002550	Mg2+ binding site [ion binding]; other site
754476002551	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
754476002552	putative active site [active]
754476002553	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
754476002554	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
754476002555	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
754476002556	putative di-iron ligands [ion binding]; other site
754476002557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
754476002558	putative DNA binding site [nucleotide binding]; other site
754476002559	dimerization interface [polypeptide binding]; other site
754476002560	putative Zn2+ binding site [ion binding]; other site
754476002561	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
754476002562	Catalytic domain of Protein Kinases; Region: PKc; cd00180
754476002563	active site
754476002564	substrate binding site [chemical binding]; other site
754476002565	activation loop (A-loop); other site
754476002566	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
754476002567	Protein phosphatase 2C; Region: PP2C; pfam00481
754476002568	active site
754476002569	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
754476002570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476002571	Walker A motif; other site
754476002572	ATP binding site [chemical binding]; other site
754476002573	Walker B motif; other site
754476002574	arginine finger; other site
754476002575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
754476002576	Integrase core domain; Region: rve; pfam00665
754476002577	Competence protein CoiA-like family; Region: CoiA; cl11541
754476002578	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
754476002579	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
754476002580	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
754476002581	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
754476002582	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476002583	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
754476002584	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
754476002585	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
754476002586	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
754476002587	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476002588	N-terminal plug; other site
754476002589	ligand-binding site [chemical binding]; other site
754476002590	Protein of unknown function (DUF502); Region: DUF502; pfam04367
754476002591	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
754476002592	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
754476002593	CPxP  motif; other site
754476002594	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
754476002595	Peptidase family M48; Region: Peptidase_M48; cl12018
754476002596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476002597	binding surface
754476002598	TPR motif; other site
754476002599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476002600	binding surface
754476002601	TPR motif; other site
754476002602	Predicted secreted protein [Function unknown]; Region: COG5501
754476002603	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
754476002604	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
754476002605	HAMP domain; Region: HAMP; pfam00672
754476002606	dimerization interface [polypeptide binding]; other site
754476002607	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476002608	PAS domain; Region: PAS_9; pfam13426
754476002609	putative active site [active]
754476002610	heme pocket [chemical binding]; other site
754476002611	Histidine kinase; Region: HisKA_3; pfam07730
754476002612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002613	ATP binding site [chemical binding]; other site
754476002614	Mg2+ binding site [ion binding]; other site
754476002615	G-X-G motif; other site
754476002616	response regulator; Provisional; Region: PRK09483
754476002617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002618	active site
754476002619	phosphorylation site [posttranslational modification]
754476002620	intermolecular recognition site; other site
754476002621	dimerization interface [polypeptide binding]; other site
754476002622	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476002623	DNA binding residues [nucleotide binding]
754476002624	dimerization interface [polypeptide binding]; other site
754476002625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476002626	Histidine kinase; Region: HisKA_3; pfam07730
754476002627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002628	ATP binding site [chemical binding]; other site
754476002629	Mg2+ binding site [ion binding]; other site
754476002630	G-X-G motif; other site
754476002631	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476002632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002633	active site
754476002634	phosphorylation site [posttranslational modification]
754476002635	intermolecular recognition site; other site
754476002636	dimerization interface [polypeptide binding]; other site
754476002637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476002638	DNA binding residues [nucleotide binding]
754476002639	dimerization interface [polypeptide binding]; other site
754476002640	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476002641	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
754476002642	Trp docking motif [polypeptide binding]; other site
754476002643	dimer interface [polypeptide binding]; other site
754476002644	active site
754476002645	small subunit binding site [polypeptide binding]; other site
754476002646	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
754476002647	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
754476002648	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
754476002649	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
754476002650	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
754476002651	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476002652	FeS/SAM binding site; other site
754476002653	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
754476002654	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
754476002655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476002656	Walker A/P-loop; other site
754476002657	ATP binding site [chemical binding]; other site
754476002658	Q-loop/lid; other site
754476002659	ABC transporter signature motif; other site
754476002660	Walker B; other site
754476002661	D-loop; other site
754476002662	H-loop/switch region; other site
754476002663	ABC-2 type transporter; Region: ABC2_membrane; cl17235
754476002664	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476002665	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
754476002666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002667	S-adenosylmethionine binding site [chemical binding]; other site
754476002668	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
754476002669	active site residue [active]
754476002670	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
754476002671	Isochorismatase family; Region: Isochorismatase; pfam00857
754476002672	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
754476002673	catalytic triad [active]
754476002674	dimer interface [polypeptide binding]; other site
754476002675	conserved cis-peptide bond; other site
754476002676	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
754476002677	B12 binding domain; Region: B12-binding; pfam02310
754476002678	B12 binding site [chemical binding]; other site
754476002679	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
754476002680	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
754476002681	exonuclease I; Provisional; Region: sbcB; PRK11779
754476002682	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
754476002683	active site
754476002684	catalytic site [active]
754476002685	substrate binding site [chemical binding]; other site
754476002686	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
754476002687	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
754476002688	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
754476002689	inhibitor-cofactor binding pocket; inhibition site
754476002690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476002691	catalytic residue [active]
754476002692	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476002693	dimerization interface [polypeptide binding]; other site
754476002694	Histidine kinase; Region: HisKA_3; pfam07730
754476002695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002696	ATP binding site [chemical binding]; other site
754476002697	Mg2+ binding site [ion binding]; other site
754476002698	G-X-G motif; other site
754476002699	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476002700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476002701	active site
754476002702	phosphorylation site [posttranslational modification]
754476002703	intermolecular recognition site; other site
754476002704	dimerization interface [polypeptide binding]; other site
754476002705	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476002706	dimerization interface [polypeptide binding]; other site
754476002707	DNA binding residues [nucleotide binding]
754476002708	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
754476002709	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
754476002710	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
754476002711	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476002712	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
754476002713	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
754476002714	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476002715	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476002716	binding surface
754476002717	TPR motif; other site
754476002718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476002719	binding surface
754476002720	TPR motif; other site
754476002721	intersubunit interface [polypeptide binding]; other site
754476002722	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
754476002723	active site
754476002724	Zn2+ binding site [ion binding]; other site
754476002725	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
754476002726	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
754476002727	Methyltransferase domain; Region: Methyltransf_31; pfam13847
754476002728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002729	S-adenosylmethionine binding site [chemical binding]; other site
754476002730	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
754476002731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476002732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476002733	homodimer interface [polypeptide binding]; other site
754476002734	catalytic residue [active]
754476002735	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
754476002736	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
754476002737	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
754476002738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476002739	Mg2+ binding site [ion binding]; other site
754476002740	G-X-G motif; other site
754476002741	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
754476002742	anchoring element; other site
754476002743	dimer interface [polypeptide binding]; other site
754476002744	ATP binding site [chemical binding]; other site
754476002745	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
754476002746	active site
754476002747	metal binding site [ion binding]; metal-binding site
754476002748	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
754476002749	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
754476002750	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
754476002751	CAP-like domain; other site
754476002752	active site
754476002753	primary dimer interface [polypeptide binding]; other site
754476002754	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
754476002755	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
754476002756	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
754476002757	4Fe-4S binding domain; Region: Fer4; pfam00037
754476002758	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
754476002759	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
754476002760	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
754476002761	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
754476002762	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
754476002763	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
754476002764	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
754476002765	[4Fe-4S] binding site [ion binding]; other site
754476002766	molybdopterin cofactor binding site; other site
754476002767	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
754476002768	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
754476002769	molybdopterin cofactor binding site; other site
754476002770	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
754476002771	4Fe-4S binding domain; Region: Fer4; cl02805
754476002772	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
754476002773	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
754476002774	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
754476002775	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
754476002776	putative dimer interface [polypeptide binding]; other site
754476002777	[2Fe-2S] cluster binding site [ion binding]; other site
754476002778	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
754476002779	SLBB domain; Region: SLBB; pfam10531
754476002780	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
754476002781	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
754476002782	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
754476002783	catalytic loop [active]
754476002784	iron binding site [ion binding]; other site
754476002785	4Fe-4S binding domain; Region: Fer4; pfam00037
754476002786	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
754476002787	[4Fe-4S] binding site [ion binding]; other site
754476002788	molybdopterin cofactor binding site; other site
754476002789	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
754476002790	molybdopterin cofactor binding site; other site
754476002791	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
754476002792	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
754476002793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002794	S-adenosylmethionine binding site [chemical binding]; other site
754476002795	Predicted membrane protein [Function unknown]; Region: COG1238
754476002796	Peptidase family M23; Region: Peptidase_M23; pfam01551
754476002797	peptide chain release factor 2; Validated; Region: prfB; PRK00578
754476002798	This domain is found in peptide chain release factors; Region: PCRF; smart00937
754476002799	RF-1 domain; Region: RF-1; pfam00472
754476002800	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
754476002801	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
754476002802	dimer interface [polypeptide binding]; other site
754476002803	putative anticodon binding site; other site
754476002804	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
754476002805	motif 1; other site
754476002806	active site
754476002807	motif 2; other site
754476002808	motif 3; other site
754476002809	integron integrase; Region: integrase_gron; TIGR02249
754476002810	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
754476002811	Int/Topo IB signature motif; other site
754476002812	Uncharacterized conserved protein [Function unknown]; Region: COG3586
754476002813	Restriction endonuclease; Region: Mrr_cat; pfam04471
754476002814	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
754476002815	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
754476002816	catalytic residues [active]
754476002817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476002818	non-specific DNA binding site [nucleotide binding]; other site
754476002819	salt bridge; other site
754476002820	sequence-specific DNA binding site [nucleotide binding]; other site
754476002821	DNA ligase; Provisional; Region: PRK09125
754476002822	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
754476002823	DNA binding site [nucleotide binding]
754476002824	active site
754476002825	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
754476002826	DNA binding site [nucleotide binding]
754476002827	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
754476002828	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
754476002829	catalytic residues [active]
754476002830	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
754476002831	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
754476002832	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476002833	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
754476002834	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476002835	catalytic residue [active]
754476002836	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476002837	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
754476002838	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476002839	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476002840	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476002841	N-terminal plug; other site
754476002842	ligand-binding site [chemical binding]; other site
754476002843	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476002844	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
754476002845	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476002846	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476002847	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476002848	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476002849	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
754476002850	K+ potassium transporter; Region: K_trans; cl15781
754476002851	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476002852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002853	S-adenosylmethionine binding site [chemical binding]; other site
754476002854	Predicted transcriptional regulator [Transcription]; Region: COG3905
754476002855	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
754476002856	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
754476002857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002858	S-adenosylmethionine binding site [chemical binding]; other site
754476002859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476002860	Major Facilitator Superfamily; Region: MFS_1; pfam07690
754476002861	putative substrate translocation pore; other site
754476002862	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
754476002863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002864	S-adenosylmethionine binding site [chemical binding]; other site
754476002865	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
754476002866	ATP binding site [chemical binding]; other site
754476002867	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
754476002868	putative catalytic site [active]
754476002869	putative metal binding site [ion binding]; other site
754476002870	putative phosphate binding site [ion binding]; other site
754476002871	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
754476002872	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
754476002873	ligand binding site [chemical binding]; other site
754476002874	flexible hinge region; other site
754476002875	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
754476002876	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
754476002877	metal binding triad; other site
754476002878	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
754476002879	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
754476002880	active site
754476002881	catalytic site [active]
754476002882	substrate binding site [chemical binding]; other site
754476002883	BCCT family transporter; Region: BCCT; pfam02028
754476002884	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
754476002885	Ligand Binding Site [chemical binding]; other site
754476002886	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
754476002887	active site lid residues [active]
754476002888	substrate binding pocket [chemical binding]; other site
754476002889	catalytic residues [active]
754476002890	substrate-Mg2+ binding site; other site
754476002891	aspartate-rich region 1; other site
754476002892	aspartate-rich region 2; other site
754476002893	RmuC family; Region: RmuC; pfam02646
754476002894	phosphoglycolate phosphatase; Provisional; Region: PRK13222
754476002895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476002896	motif II; other site
754476002897	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
754476002898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476002899	S-adenosylmethionine binding site [chemical binding]; other site
754476002900	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
754476002901	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
754476002902	active site
754476002903	putative substrate binding pocket [chemical binding]; other site
754476002904	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
754476002905	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
754476002906	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
754476002907	C factor cell-cell signaling protein; Provisional; Region: PRK09009
754476002908	NADP binding site [chemical binding]; other site
754476002909	homodimer interface [polypeptide binding]; other site
754476002910	active site
754476002911	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
754476002912	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
754476002913	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476002914	N-terminal plug; other site
754476002915	ligand-binding site [chemical binding]; other site
754476002916	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
754476002917	putative hydrophobic ligand binding site [chemical binding]; other site
754476002918	protein interface [polypeptide binding]; other site
754476002919	gate; other site
754476002920	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
754476002921	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476002922	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
754476002923	substrate binding site [chemical binding]; other site
754476002924	dimerization interface [polypeptide binding]; other site
754476002925	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
754476002926	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
754476002927	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
754476002928	Active Sites [active]
754476002929	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
754476002930	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
754476002931	Active Sites [active]
754476002932	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
754476002933	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
754476002934	CysD dimerization site [polypeptide binding]; other site
754476002935	G1 box; other site
754476002936	putative GEF interaction site [polypeptide binding]; other site
754476002937	GTP/Mg2+ binding site [chemical binding]; other site
754476002938	Switch I region; other site
754476002939	G2 box; other site
754476002940	G3 box; other site
754476002941	Switch II region; other site
754476002942	G4 box; other site
754476002943	G5 box; other site
754476002944	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
754476002945	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
754476002946	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476002947	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
754476002948	putative active site [active]
754476002949	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
754476002950	FAD binding domain; Region: FAD_binding_4; pfam01565
754476002951	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
754476002952	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
754476002953	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
754476002954	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
754476002955	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
754476002956	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
754476002957	active site
754476002958	metal binding site [ion binding]; metal-binding site
754476002959	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
754476002960	homopentamer interface [polypeptide binding]; other site
754476002961	active site
754476002962	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
754476002963	putative RNA binding site [nucleotide binding]; other site
754476002964	thiamine monophosphate kinase; Provisional; Region: PRK05731
754476002965	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
754476002966	ATP binding site [chemical binding]; other site
754476002967	dimerization interface [polypeptide binding]; other site
754476002968	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
754476002969	tetramer interfaces [polypeptide binding]; other site
754476002970	binuclear metal-binding site [ion binding]; other site
754476002971	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
754476002972	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
754476002973	substrate binding site [chemical binding]; other site
754476002974	ATP binding site [chemical binding]; other site
754476002975	ribonuclease D; Region: rnd; TIGR01388
754476002976	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
754476002977	catalytic site [active]
754476002978	putative active site [active]
754476002979	putative substrate binding site [chemical binding]; other site
754476002980	HRDC domain; Region: HRDC; pfam00570
754476002981	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
754476002982	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
754476002983	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
754476002984	MPT binding site; other site
754476002985	trimer interface [polypeptide binding]; other site
754476002986	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
754476002987	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476002988	ligand binding site [chemical binding]; other site
754476002989	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
754476002990	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
754476002991	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
754476002992	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
754476002993	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
754476002994	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
754476002995	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
754476002996	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
754476002997	replicative DNA helicase; Region: DnaB; TIGR00665
754476002998	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
754476002999	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
754476003000	Walker A motif; other site
754476003001	ATP binding site [chemical binding]; other site
754476003002	Walker B motif; other site
754476003003	DNA binding loops [nucleotide binding]
754476003004	alanine racemase; Reviewed; Region: alr; PRK00053
754476003005	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
754476003006	active site
754476003007	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
754476003008	substrate binding site [chemical binding]; other site
754476003009	catalytic residues [active]
754476003010	dimer interface [polypeptide binding]; other site
754476003011	DNA repair protein RadA; Provisional; Region: PRK11823
754476003012	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
754476003013	Walker A motif/ATP binding site; other site
754476003014	ATP binding site [chemical binding]; other site
754476003015	Walker B motif; other site
754476003016	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
754476003017	PilZ domain; Region: PilZ; pfam07238
754476003018	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
754476003019	BON domain; Region: BON; pfam04972
754476003020	BON domain; Region: BON; pfam04972
754476003021	hypothetical protein; Reviewed; Region: PRK12497
754476003022	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
754476003023	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
754476003024	putative ligand binding site [chemical binding]; other site
754476003025	Predicted methyltransferases [General function prediction only]; Region: COG0313
754476003026	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
754476003027	putative SAM binding site [chemical binding]; other site
754476003028	putative homodimer interface [polypeptide binding]; other site
754476003029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476003030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476003031	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
754476003032	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
754476003033	Protein export membrane protein; Region: SecD_SecF; cl14618
754476003034	Cytochrome C' Region: Cytochrom_C_2; cl01610
754476003035	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476003036	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476003037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
754476003038	Transposase; Region: DDE_Tnp_ISL3; pfam01610
754476003039	cell division protein MraZ; Reviewed; Region: PRK00326
754476003040	MraZ protein; Region: MraZ; pfam02381
754476003041	MraZ protein; Region: MraZ; pfam02381
754476003042	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
754476003043	MraW methylase family; Region: Methyltransf_5; pfam01795
754476003044	Cell division protein FtsL; Region: FtsL; pfam04999
754476003045	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
754476003046	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
754476003047	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
754476003048	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
754476003049	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
754476003050	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
754476003051	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
754476003052	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
754476003053	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
754476003054	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
754476003055	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
754476003056	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
754476003057	Mg++ binding site [ion binding]; other site
754476003058	putative catalytic motif [active]
754476003059	putative substrate binding site [chemical binding]; other site
754476003060	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
754476003061	TrkA-N domain; Region: TrkA_N; pfam02254
754476003062	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
754476003063	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
754476003064	cell division protein FtsW; Region: ftsW; TIGR02614
754476003065	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
754476003066	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
754476003067	active site
754476003068	homodimer interface [polypeptide binding]; other site
754476003069	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
754476003070	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
754476003071	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
754476003072	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
754476003073	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
754476003074	FAD binding domain; Region: FAD_binding_4; pfam01565
754476003075	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
754476003076	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
754476003077	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
754476003078	ATP-grasp domain; Region: ATP-grasp_4; cl17255
754476003079	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
754476003080	Cell division protein FtsQ; Region: FtsQ; pfam03799
754476003081	cell division protein FtsA; Region: ftsA; TIGR01174
754476003082	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
754476003083	nucleotide binding site [chemical binding]; other site
754476003084	Cell division protein FtsA; Region: FtsA; pfam14450
754476003085	cell division protein FtsZ; Validated; Region: PRK09330
754476003086	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
754476003087	nucleotide binding site [chemical binding]; other site
754476003088	SulA interaction site; other site
754476003089	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
754476003090	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
754476003091	Protein of unknown function (DUF721); Region: DUF721; pfam05258
754476003092	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
754476003093	Peptidase family M23; Region: Peptidase_M23; pfam01551
754476003094	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
754476003095	DEAD/DEAH box helicase; Region: DEAD; pfam00270
754476003096	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
754476003097	SEC-C motif; Region: SEC-C; pfam02810
754476003098	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
754476003099	heterotetramer interface [polypeptide binding]; other site
754476003100	active site pocket [active]
754476003101	cleavage site
754476003102	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
754476003103	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
754476003104	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
754476003105	active site
754476003106	catalytic residues [active]
754476003107	metal binding site [ion binding]; metal-binding site
754476003108	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
754476003109	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
754476003110	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
754476003111	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
754476003112	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
754476003113	ATP binding site [chemical binding]; other site
754476003114	Mg++ binding site [ion binding]; other site
754476003115	motif III; other site
754476003116	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476003117	nucleotide binding region [chemical binding]; other site
754476003118	ATP-binding site [chemical binding]; other site
754476003119	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
754476003120	putative RNA binding site [nucleotide binding]; other site
754476003121	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
754476003122	Dodecin; Region: Dodecin; pfam07311
754476003123	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
754476003124	putative amphipathic alpha helix; other site
754476003125	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
754476003126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476003127	Walker A/P-loop; other site
754476003128	ATP binding site [chemical binding]; other site
754476003129	Q-loop/lid; other site
754476003130	ABC transporter signature motif; other site
754476003131	Walker B; other site
754476003132	D-loop; other site
754476003133	H-loop/switch region; other site
754476003134	ABC transporter; Region: ABC_tran_2; pfam12848
754476003135	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476003136	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
754476003137	GIY-YIG motif/motif A; other site
754476003138	putative active site [active]
754476003139	putative metal binding site [ion binding]; other site
754476003140	methionine sulfoxide reductase B; Provisional; Region: PRK00222
754476003141	SelR domain; Region: SelR; pfam01641
754476003142	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476003143	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
754476003144	substrate binding pocket [chemical binding]; other site
754476003145	membrane-bound complex binding site; other site
754476003146	hinge residues; other site
754476003147	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
754476003148	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476003149	substrate binding pocket [chemical binding]; other site
754476003150	membrane-bound complex binding site; other site
754476003151	hinge residues; other site
754476003152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476003153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476003154	dimer interface [polypeptide binding]; other site
754476003155	phosphorylation site [posttranslational modification]
754476003156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476003157	ATP binding site [chemical binding]; other site
754476003158	Mg2+ binding site [ion binding]; other site
754476003159	G-X-G motif; other site
754476003160	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476003161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476003162	active site
754476003163	phosphorylation site [posttranslational modification]
754476003164	intermolecular recognition site; other site
754476003165	dimerization interface [polypeptide binding]; other site
754476003166	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
754476003167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476003168	active site
754476003169	phosphorylation site [posttranslational modification]
754476003170	intermolecular recognition site; other site
754476003171	dimerization interface [polypeptide binding]; other site
754476003172	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476003173	Zn2+ binding site [ion binding]; other site
754476003174	Mg2+ binding site [ion binding]; other site
754476003175	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
754476003176	ligand binding site [chemical binding]; other site
754476003177	active site
754476003178	UGI interface [polypeptide binding]; other site
754476003179	catalytic site [active]
754476003180	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
754476003181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476003182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476003183	ABC transporter; Region: ABC_tran_2; pfam12848
754476003184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476003185	ABC transporter ATPase component; Reviewed; Region: PRK11147
754476003186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476003187	Walker A/P-loop; other site
754476003188	ATP binding site [chemical binding]; other site
754476003189	Q-loop/lid; other site
754476003190	ABC transporter signature motif; other site
754476003191	Walker B; other site
754476003192	D-loop; other site
754476003193	H-loop/switch region; other site
754476003194	ABC transporter; Region: ABC_tran_2; pfam12848
754476003195	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476003196	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
754476003197	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
754476003198	DNA-binding site [nucleotide binding]; DNA binding site
754476003199	RNA-binding motif; other site
754476003200	oxidative damage protection protein; Provisional; Region: PRK05408
754476003201	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
754476003202	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
754476003203	minor groove reading motif; other site
754476003204	helix-hairpin-helix signature motif; other site
754476003205	substrate binding pocket [chemical binding]; other site
754476003206	active site
754476003207	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
754476003208	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
754476003209	DNA binding and oxoG recognition site [nucleotide binding]
754476003210	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
754476003211	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
754476003212	Domain of unknown function DUF21; Region: DUF21; pfam01595
754476003213	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
754476003214	Transporter associated domain; Region: CorC_HlyC; smart01091
754476003215	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
754476003216	signal recognition particle protein; Provisional; Region: PRK10867
754476003217	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
754476003218	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
754476003219	P loop; other site
754476003220	GTP binding site [chemical binding]; other site
754476003221	Signal peptide binding domain; Region: SRP_SPB; pfam02978
754476003222	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
754476003223	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
754476003224	RimM N-terminal domain; Region: RimM; pfam01782
754476003225	PRC-barrel domain; Region: PRC; pfam05239
754476003226	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
754476003227	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
754476003228	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
754476003229	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
754476003230	active site
754476003231	Int/Topo IB signature motif; other site
754476003232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
754476003233	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
754476003234	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
754476003235	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
754476003236	dimerization domain [polypeptide binding]; other site
754476003237	dimer interface [polypeptide binding]; other site
754476003238	catalytic residues [active]
754476003239	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
754476003240	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
754476003241	putative active site [active]
754476003242	putative metal binding site [ion binding]; other site
754476003243	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
754476003244	substrate binding site [chemical binding]; other site
754476003245	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
754476003246	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
754476003247	active site
754476003248	HIGH motif; other site
754476003249	nucleotide binding site [chemical binding]; other site
754476003250	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
754476003251	KMSKS motif; other site
754476003252	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
754476003253	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
754476003254	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
754476003255	active site
754476003256	HIGH motif; other site
754476003257	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
754476003258	KMSKS motif; other site
754476003259	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
754476003260	tRNA binding surface [nucleotide binding]; other site
754476003261	anticodon binding site; other site
754476003262	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
754476003263	propionate/acetate kinase; Provisional; Region: PRK12379
754476003264	putative phosphoketolase; Provisional; Region: PRK05261
754476003265	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
754476003266	TPP-binding site; other site
754476003267	XFP C-terminal domain; Region: XFP_C; pfam09363
754476003268	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
754476003269	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
754476003270	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
754476003271	homodimer interface [polypeptide binding]; other site
754476003272	NADP binding site [chemical binding]; other site
754476003273	substrate binding site [chemical binding]; other site
754476003274	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476003275	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
754476003276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476003277	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476003278	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
754476003279	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
754476003280	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
754476003281	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
754476003282	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
754476003283	NAD binding site [chemical binding]; other site
754476003284	substrate binding site [chemical binding]; other site
754476003285	homodimer interface [polypeptide binding]; other site
754476003286	active site
754476003287	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
754476003288	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
754476003289	substrate binding site; other site
754476003290	tetramer interface; other site
754476003291	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
754476003292	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
754476003293	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
754476003294	NADP binding site [chemical binding]; other site
754476003295	active site
754476003296	putative substrate binding site [chemical binding]; other site
754476003297	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
754476003298	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
754476003299	NAD(P) binding site [chemical binding]; other site
754476003300	homodimer interface [polypeptide binding]; other site
754476003301	substrate binding site [chemical binding]; other site
754476003302	active site
754476003303	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
754476003304	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
754476003305	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
754476003306	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
754476003307	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
754476003308	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
754476003309	glutaminase active site [active]
754476003310	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
754476003311	dimer interface [polypeptide binding]; other site
754476003312	active site
754476003313	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
754476003314	dimer interface [polypeptide binding]; other site
754476003315	active site
754476003316	EPS-associated transcriptional regulator, MarR family; Region: MarR_EPS; TIGR04176
754476003317	putative DNA binding site [nucleotide binding]; other site
754476003318	putative Zn2+ binding site [ion binding]; other site
754476003319	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
754476003320	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
754476003321	inhibitor-cofactor binding pocket; inhibition site
754476003322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476003323	catalytic residue [active]
754476003324	WbqC-like protein family; Region: WbqC; pfam08889
754476003325	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
754476003326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476003327	NAD(P) binding site [chemical binding]; other site
754476003328	active site
754476003329	Spc19; Region: DASH_Spc19; pfam08287
754476003330	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
754476003331	colanic acid exporter; Provisional; Region: PRK10459
754476003332	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
754476003333	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
754476003334	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
754476003335	active site
754476003336	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
754476003337	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
754476003338	active site
754476003339	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
754476003340	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
754476003341	Probable Catalytic site; other site
754476003342	metal-binding site
754476003343	phosphomannomutase CpsG; Provisional; Region: PRK15414
754476003344	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
754476003345	active site
754476003346	substrate binding site [chemical binding]; other site
754476003347	metal binding site [ion binding]; metal-binding site
754476003348	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
754476003349	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
754476003350	putative NAD(P) binding site [chemical binding]; other site
754476003351	active site
754476003352	putative substrate binding site [chemical binding]; other site
754476003353	Bacterial sugar transferase; Region: Bac_transf; pfam02397
754476003354	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
754476003355	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
754476003356	Cupin domain; Region: Cupin_2; cl17218
754476003357	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
754476003358	active site
754476003359	metal binding site [ion binding]; metal-binding site
754476003360	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
754476003361	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
754476003362	Ligand binding site; other site
754476003363	oligomer interface; other site
754476003364	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
754476003365	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
754476003366	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476003367	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
754476003368	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
754476003369	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
754476003370	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
754476003371	NADP-binding site; other site
754476003372	homotetramer interface [polypeptide binding]; other site
754476003373	substrate binding site [chemical binding]; other site
754476003374	homodimer interface [polypeptide binding]; other site
754476003375	active site
754476003376	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
754476003377	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
754476003378	NADP-binding site; other site
754476003379	homotetramer interface [polypeptide binding]; other site
754476003380	substrate binding site [chemical binding]; other site
754476003381	homodimer interface [polypeptide binding]; other site
754476003382	active site
754476003383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476003384	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
754476003385	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
754476003386	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476003387	putative ADP-binding pocket [chemical binding]; other site
754476003388	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
754476003389	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
754476003390	Walker A/P-loop; other site
754476003391	ATP binding site [chemical binding]; other site
754476003392	Q-loop/lid; other site
754476003393	ABC transporter signature motif; other site
754476003394	Walker B; other site
754476003395	D-loop; other site
754476003396	H-loop/switch region; other site
754476003397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476003398	TPR motif; other site
754476003399	TPR repeat; Region: TPR_11; pfam13414
754476003400	binding surface
754476003401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476003402	binding surface
754476003403	TPR motif; other site
754476003404	Tetratricopeptide repeat; Region: TPR_16; pfam13432
754476003405	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
754476003406	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
754476003407	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
754476003408	ligand-binding site [chemical binding]; other site
754476003409	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
754476003410	Helix-hairpin-helix motif; Region: HHH; pfam00633
754476003411	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
754476003412	LAGLIDADG endonuclease; Region: LAGLIDADG_1; pfam00961
754476003413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
754476003414	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
754476003415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
754476003416	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
754476003417	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
754476003418	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
754476003419	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
754476003420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
754476003421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
754476003422	Transposase; Region: HTH_Tnp_1; pfam01527
754476003423	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
754476003424	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
754476003425	metal binding triad; other site
754476003426	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
754476003427	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476003428	Zn2+ binding site [ion binding]; other site
754476003429	Mg2+ binding site [ion binding]; other site
754476003430	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
754476003431	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
754476003432	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
754476003433	active site
754476003434	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
754476003435	rRNA interaction site [nucleotide binding]; other site
754476003436	S8 interaction site; other site
754476003437	putative laminin-1 binding site; other site
754476003438	elongation factor Ts; Provisional; Region: tsf; PRK09377
754476003439	UBA/TS-N domain; Region: UBA; pfam00627
754476003440	Elongation factor TS; Region: EF_TS; pfam00889
754476003441	Elongation factor TS; Region: EF_TS; pfam00889
754476003442	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
754476003443	putative nucleotide binding site [chemical binding]; other site
754476003444	uridine monophosphate binding site [chemical binding]; other site
754476003445	homohexameric interface [polypeptide binding]; other site
754476003446	ribosome recycling factor; Reviewed; Region: frr; PRK00083
754476003447	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
754476003448	hinge region; other site
754476003449	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
754476003450	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
754476003451	catalytic residue [active]
754476003452	putative FPP diphosphate  binding site; other site
754476003453	putative FPP binding hydrophobic cleft; other site
754476003454	dimer interface [polypeptide binding]; other site
754476003455	putative IPP diphosphate binding site; other site
754476003456	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
754476003457	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
754476003458	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
754476003459	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
754476003460	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
754476003461	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
754476003462	zinc metallopeptidase RseP; Provisional; Region: PRK10779
754476003463	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
754476003464	active site
754476003465	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
754476003466	protein binding site [polypeptide binding]; other site
754476003467	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
754476003468	protein binding site [polypeptide binding]; other site
754476003469	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
754476003470	putative substrate binding region [chemical binding]; other site
754476003471	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
754476003472	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476003473	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476003474	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476003475	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476003476	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476003477	Surface antigen; Region: Bac_surface_Ag; pfam01103
754476003478	periplasmic chaperone; Provisional; Region: PRK10780
754476003479	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
754476003480	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
754476003481	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
754476003482	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
754476003483	trimer interface [polypeptide binding]; other site
754476003484	active site
754476003485	UDP-GlcNAc binding site [chemical binding]; other site
754476003486	lipid binding site [chemical binding]; lipid-binding site
754476003487	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
754476003488	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
754476003489	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
754476003490	active site
754476003491	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
754476003492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
754476003493	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
754476003494	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
754476003495	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
754476003496	Trp docking motif [polypeptide binding]; other site
754476003497	GTP-binding protein Der; Reviewed; Region: PRK00093
754476003498	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
754476003499	G1 box; other site
754476003500	GTP/Mg2+ binding site [chemical binding]; other site
754476003501	Switch I region; other site
754476003502	G2 box; other site
754476003503	Switch II region; other site
754476003504	G3 box; other site
754476003505	G4 box; other site
754476003506	G5 box; other site
754476003507	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
754476003508	G1 box; other site
754476003509	GTP/Mg2+ binding site [chemical binding]; other site
754476003510	Switch I region; other site
754476003511	G2 box; other site
754476003512	G3 box; other site
754476003513	Switch II region; other site
754476003514	G4 box; other site
754476003515	G5 box; other site
754476003516	putative glutathione S-transferase; Provisional; Region: PRK10357
754476003517	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
754476003518	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
754476003519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476003520	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
754476003521	Walker A/P-loop; other site
754476003522	ATP binding site [chemical binding]; other site
754476003523	Q-loop/lid; other site
754476003524	ABC transporter signature motif; other site
754476003525	Walker B; other site
754476003526	D-loop; other site
754476003527	H-loop/switch region; other site
754476003528	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
754476003529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476003530	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476003531	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476003532	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476003533	DNA binding residues [nucleotide binding]
754476003534	dimerization interface [polypeptide binding]; other site
754476003535	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
754476003536	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
754476003537	active site 1 [active]
754476003538	dimer interface [polypeptide binding]; other site
754476003539	active site 2 [active]
754476003540	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
754476003541	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
754476003542	dimer interface [polypeptide binding]; other site
754476003543	active site
754476003544	acyl-CoA esterase; Provisional; Region: PRK10673
754476003545	PGAP1-like protein; Region: PGAP1; pfam07819
754476003546	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
754476003547	homodimer interface [polypeptide binding]; other site
754476003548	chemical substrate binding site [chemical binding]; other site
754476003549	oligomer interface [polypeptide binding]; other site
754476003550	metal binding site [ion binding]; metal-binding site
754476003551	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
754476003552	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
754476003553	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
754476003554	putative active site [active]
754476003555	putative substrate binding site [chemical binding]; other site
754476003556	putative cosubstrate binding site; other site
754476003557	catalytic site [active]
754476003558	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
754476003559	malonic semialdehyde reductase; Provisional; Region: PRK10538
754476003560	putative NAD(P) binding site [chemical binding]; other site
754476003561	homodimer interface [polypeptide binding]; other site
754476003562	homotetramer interface [polypeptide binding]; other site
754476003563	active site
754476003564	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
754476003565	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476003566	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
754476003567	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
754476003568	metal binding site [ion binding]; metal-binding site
754476003569	dimer interface [polypeptide binding]; other site
754476003570	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
754476003571	ArsC family; Region: ArsC; pfam03960
754476003572	putative catalytic residues [active]
754476003573	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
754476003574	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
754476003575	active site
754476003576	substrate binding site [chemical binding]; other site
754476003577	trimer interface [polypeptide binding]; other site
754476003578	CoA binding site [chemical binding]; other site
754476003579	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
754476003580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476003581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476003582	homodimer interface [polypeptide binding]; other site
754476003583	catalytic residue [active]
754476003584	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
754476003585	EamA-like transporter family; Region: EamA; pfam00892
754476003586	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
754476003587	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
754476003588	dimer interface [polypeptide binding]; other site
754476003589	putative metal binding site [ion binding]; other site
754476003590	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
754476003591	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
754476003592	Ligand Binding Site [chemical binding]; other site
754476003593	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
754476003594	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
754476003595	dimer interface [polypeptide binding]; other site
754476003596	putative functional site; other site
754476003597	putative MPT binding site; other site
754476003598	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional; Region: PRK14489
754476003599	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
754476003600	GTP binding site; other site
754476003601	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
754476003602	Walker A motif; other site
754476003603	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
754476003604	catalytic motif [active]
754476003605	Catalytic residue [active]
754476003606	putative GTP cyclohydrolase; Provisional; Region: PRK13674
754476003607	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
754476003608	active site
754476003609	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
754476003610	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
754476003611	TPP-binding site; other site
754476003612	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
754476003613	PYR/PP interface [polypeptide binding]; other site
754476003614	dimer interface [polypeptide binding]; other site
754476003615	TPP binding site [chemical binding]; other site
754476003616	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
754476003617	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
754476003618	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
754476003619	substrate binding pocket [chemical binding]; other site
754476003620	chain length determination region; other site
754476003621	substrate-Mg2+ binding site; other site
754476003622	catalytic residues [active]
754476003623	aspartate-rich region 1; other site
754476003624	active site lid residues [active]
754476003625	aspartate-rich region 2; other site
754476003626	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
754476003627	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
754476003628	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
754476003629	active site
754476003630	Riboflavin kinase; Region: Flavokinase; smart00904
754476003631	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
754476003632	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
754476003633	NlpE N-terminal domain; Region: NlpE; pfam04170
754476003634	META domain; Region: META; pfam03724
754476003635	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
754476003636	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
754476003637	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
754476003638	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
754476003639	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
754476003640	Domain of unknown function (DUF202); Region: DUF202; pfam02656
754476003641	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
754476003642	ferredoxin-NADP reductase; Provisional; Region: PRK10926
754476003643	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
754476003644	FAD binding pocket [chemical binding]; other site
754476003645	FAD binding motif [chemical binding]; other site
754476003646	phosphate binding motif [ion binding]; other site
754476003647	beta-alpha-beta structure motif; other site
754476003648	NAD binding pocket [chemical binding]; other site
754476003649	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
754476003650	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
754476003651	metal binding site [ion binding]; metal-binding site
754476003652	dimer interface [polypeptide binding]; other site
754476003653	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
754476003654	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
754476003655	inhibitor-cofactor binding pocket; inhibition site
754476003656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476003657	catalytic residue [active]
754476003658	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
754476003659	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
754476003660	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
754476003661	active site
754476003662	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
754476003663	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
754476003664	NAD(P) binding site [chemical binding]; other site
754476003665	catalytic residues [active]
754476003666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
754476003667	Protein of unknown function (DUF330); Region: DUF330; pfam03886
754476003668	paraquat-inducible protein B; Provisional; Region: PRK10807
754476003669	mce related protein; Region: MCE; pfam02470
754476003670	mce related protein; Region: MCE; pfam02470
754476003671	mce related protein; Region: MCE; pfam02470
754476003672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
754476003673	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
754476003674	Paraquat-inducible protein A; Region: PqiA; pfam04403
754476003675	Paraquat-inducible protein A; Region: PqiA; pfam04403
754476003676	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
754476003677	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
754476003678	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
754476003679	PhnA protein; Region: PhnA; pfam03831
754476003680	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476003681	dimerization interface [polypeptide binding]; other site
754476003682	putative DNA binding site [nucleotide binding]; other site
754476003683	putative Zn2+ binding site [ion binding]; other site
754476003684	Predicted permease; Region: DUF318; pfam03773
754476003685	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
754476003686	dimer interface [polypeptide binding]; other site
754476003687	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
754476003688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
754476003689	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
754476003690	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
754476003691	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
754476003692	dimer interface [polypeptide binding]; other site
754476003693	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
754476003694	SnoaL-like domain; Region: SnoaL_3; pfam13474
754476003695	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
754476003696	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476003697	dimerization interface [polypeptide binding]; other site
754476003698	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476003699	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476003700	metal binding site [ion binding]; metal-binding site
754476003701	active site
754476003702	I-site; other site
754476003703	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476003704	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
754476003705	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476003706	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
754476003707	NADH(P)-binding; Region: NAD_binding_10; pfam13460
754476003708	NAD(P) binding site [chemical binding]; other site
754476003709	putative active site [active]
754476003710	Major Facilitator Superfamily; Region: MFS_1; pfam07690
754476003711	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
754476003712	catalytic core [active]
754476003713	putative mechanosensitive channel protein; Provisional; Region: PRK11465
754476003714	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476003715	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
754476003716	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
754476003717	ATP binding site [chemical binding]; other site
754476003718	Mg++ binding site [ion binding]; other site
754476003719	motif III; other site
754476003720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476003721	nucleotide binding region [chemical binding]; other site
754476003722	ATP-binding site [chemical binding]; other site
754476003723	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
754476003724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476003725	PAS fold; Region: PAS_3; pfam08447
754476003726	putative active site [active]
754476003727	heme pocket [chemical binding]; other site
754476003728	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476003729	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476003730	metal binding site [ion binding]; metal-binding site
754476003731	active site
754476003732	I-site; other site
754476003733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
754476003734	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
754476003735	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
754476003736	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476003737	dimerization interface [polypeptide binding]; other site
754476003738	putative DNA binding site [nucleotide binding]; other site
754476003739	putative Zn2+ binding site [ion binding]; other site
754476003740	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
754476003741	putative deacylase active site [active]
754476003742	Predicted membrane protein [Function unknown]; Region: COG2119
754476003743	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
754476003744	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
754476003745	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
754476003746	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
754476003747	putative ATP binding site [chemical binding]; other site
754476003748	putative substrate interface [chemical binding]; other site
754476003749	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
754476003750	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
754476003751	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
754476003752	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
754476003753	Protein of unknown function DUF58; Region: DUF58; pfam01882
754476003754	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476003755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476003756	Walker A motif; other site
754476003757	ATP binding site [chemical binding]; other site
754476003758	Walker B motif; other site
754476003759	arginine finger; other site
754476003760	Uncharacterized conserved protein [Function unknown]; Region: COG3461
754476003761	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
754476003762	active site
754476003763	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
754476003764	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
754476003765	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
754476003766	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
754476003767	active site residue [active]
754476003768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
754476003769	Peptidase M15; Region: Peptidase_M15_3; cl01194
754476003770	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
754476003771	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
754476003772	ABC-ATPase subunit  interface; other site
754476003773	dimer interface [polypeptide binding]; other site
754476003774	putative PBP binding regions; other site
754476003775	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
754476003776	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
754476003777	Walker A/P-loop; other site
754476003778	ATP binding site [chemical binding]; other site
754476003779	Q-loop/lid; other site
754476003780	ABC transporter signature motif; other site
754476003781	Walker B; other site
754476003782	D-loop; other site
754476003783	H-loop/switch region; other site
754476003784	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
754476003785	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
754476003786	intersubunit interface [polypeptide binding]; other site
754476003787	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476003788	active site
754476003789	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
754476003790	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
754476003791	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
754476003792	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
754476003793	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
754476003794	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
754476003795	catalytic core [active]
754476003796	Uncharacterized conserved protein [Function unknown]; Region: COG2850
754476003797	Cupin-like domain; Region: Cupin_8; pfam13621
754476003798	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
754476003799	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
754476003800	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
754476003801	rRNA binding site [nucleotide binding]; other site
754476003802	predicted 30S ribosome binding site; other site
754476003803	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
754476003804	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
754476003805	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
754476003806	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
754476003807	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
754476003808	recombination protein RecR; Reviewed; Region: recR; PRK00076
754476003809	RecR protein; Region: RecR; pfam02132
754476003810	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
754476003811	putative active site [active]
754476003812	putative metal-binding site [ion binding]; other site
754476003813	tetramer interface [polypeptide binding]; other site
754476003814	hypothetical protein; Validated; Region: PRK00153
754476003815	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
754476003816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476003817	Walker A motif; other site
754476003818	ATP binding site [chemical binding]; other site
754476003819	Walker B motif; other site
754476003820	arginine finger; other site
754476003821	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
754476003822	pantothenate kinase; Reviewed; Region: PRK13328
754476003823	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
754476003824	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
754476003825	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
754476003826	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
754476003827	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
754476003828	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
754476003829	ArsC family; Region: ArsC; pfam03960
754476003830	catalytic residues [active]
754476003831	tetratricopeptide repeat protein; Provisional; Region: PRK11788
754476003832	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476003833	binding surface
754476003834	TPR motif; other site
754476003835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476003836	binding surface
754476003837	TPR motif; other site
754476003838	Ferredoxin [Energy production and conversion]; Region: COG1146
754476003839	4Fe-4S binding domain; Region: Fer4; cl02805
754476003840	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
754476003841	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
754476003842	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476003843	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476003844	DNA binding residues [nucleotide binding]
754476003845	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
754476003846	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
754476003847	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
754476003848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476003849	Walker A/P-loop; other site
754476003850	ATP binding site [chemical binding]; other site
754476003851	Q-loop/lid; other site
754476003852	ABC transporter signature motif; other site
754476003853	Walker B; other site
754476003854	D-loop; other site
754476003855	H-loop/switch region; other site
754476003856	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
754476003857	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
754476003858	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
754476003859	P loop; other site
754476003860	GTP binding site [chemical binding]; other site
754476003861	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
754476003862	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
754476003863	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
754476003864	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
754476003865	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
754476003866	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
754476003867	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
754476003868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476003869	S-adenosylmethionine binding site [chemical binding]; other site
754476003870	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
754476003871	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
754476003872	active site
754476003873	(T/H)XGH motif; other site
754476003874	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
754476003875	H-NS histone family; Region: Histone_HNS; pfam00816
754476003876	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
754476003877	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
754476003878	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
754476003879	HIGH motif; other site
754476003880	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
754476003881	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
754476003882	active site
754476003883	KMSKS motif; other site
754476003884	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
754476003885	tRNA binding surface [nucleotide binding]; other site
754476003886	Lipopolysaccharide-assembly; Region: LptE; cl01125
754476003887	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
754476003888	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
754476003889	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
754476003890	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
754476003891	putative catalytic cysteine [active]
754476003892	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
754476003893	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
754476003894	active site
754476003895	(T/H)XGH motif; other site
754476003896	Uncharacterized conserved protein [Function unknown]; Region: COG1434
754476003897	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
754476003898	putative active site [active]
754476003899	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
754476003900	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
754476003901	Maf-like protein; Region: Maf; pfam02545
754476003902	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
754476003903	active site
754476003904	dimer interface [polypeptide binding]; other site
754476003905	ribonuclease G; Provisional; Region: PRK11712
754476003906	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
754476003907	homodimer interface [polypeptide binding]; other site
754476003908	oligonucleotide binding site [chemical binding]; other site
754476003909	TIGR02099 family protein; Region: TIGR02099
754476003910	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
754476003911	protease TldD; Provisional; Region: tldD; PRK10735
754476003912	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
754476003913	CPxP  motif; other site
754476003914	glutamine synthetase; Provisional; Region: glnA; PRK09469
754476003915	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
754476003916	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
754476003917	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
754476003918	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
754476003919	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476003920	dimer interface [polypeptide binding]; other site
754476003921	phosphorylation site [posttranslational modification]
754476003922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476003923	ATP binding site [chemical binding]; other site
754476003924	Mg2+ binding site [ion binding]; other site
754476003925	G-X-G motif; other site
754476003926	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
754476003927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476003928	active site
754476003929	phosphorylation site [posttranslational modification]
754476003930	intermolecular recognition site; other site
754476003931	dimerization interface [polypeptide binding]; other site
754476003932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476003933	Walker A motif; other site
754476003934	ATP binding site [chemical binding]; other site
754476003935	Walker B motif; other site
754476003936	arginine finger; other site
754476003937	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476003938	ribosome maturation protein RimP; Reviewed; Region: PRK00092
754476003939	Sm and related proteins; Region: Sm_like; cl00259
754476003940	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
754476003941	putative RNA binding site [nucleotide binding]; other site
754476003942	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
754476003943	NusA N-terminal domain; Region: NusA_N; pfam08529
754476003944	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
754476003945	RNA binding site [nucleotide binding]; other site
754476003946	homodimer interface [polypeptide binding]; other site
754476003947	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
754476003948	G-X-X-G motif; other site
754476003949	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
754476003950	G-X-X-G motif; other site
754476003951	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
754476003952	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
754476003953	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
754476003954	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
754476003955	translation initiation factor IF-2; Region: IF-2; TIGR00487
754476003956	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
754476003957	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
754476003958	G1 box; other site
754476003959	putative GEF interaction site [polypeptide binding]; other site
754476003960	GTP/Mg2+ binding site [chemical binding]; other site
754476003961	Switch I region; other site
754476003962	G2 box; other site
754476003963	G3 box; other site
754476003964	Switch II region; other site
754476003965	G4 box; other site
754476003966	G5 box; other site
754476003967	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
754476003968	Translation-initiation factor 2; Region: IF-2; pfam11987
754476003969	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
754476003970	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
754476003971	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
754476003972	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
754476003973	RNA binding site [nucleotide binding]; other site
754476003974	active site
754476003975	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
754476003976	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
754476003977	16S/18S rRNA binding site [nucleotide binding]; other site
754476003978	S13e-L30e interaction site [polypeptide binding]; other site
754476003979	25S rRNA binding site [nucleotide binding]; other site
754476003980	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
754476003981	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
754476003982	RNase E interface [polypeptide binding]; other site
754476003983	trimer interface [polypeptide binding]; other site
754476003984	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
754476003985	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
754476003986	RNase E interface [polypeptide binding]; other site
754476003987	trimer interface [polypeptide binding]; other site
754476003988	active site
754476003989	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
754476003990	putative nucleic acid binding region [nucleotide binding]; other site
754476003991	G-X-X-G motif; other site
754476003992	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
754476003993	RNA binding site [nucleotide binding]; other site
754476003994	domain interface; other site
754476003995	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
754476003996	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
754476003997	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
754476003998	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476003999	dimer interface [polypeptide binding]; other site
754476004000	conserved gate region; other site
754476004001	putative PBP binding loops; other site
754476004002	ABC-ATPase subunit interface; other site
754476004003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476004004	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
754476004005	Walker A/P-loop; other site
754476004006	ATP binding site [chemical binding]; other site
754476004007	Q-loop/lid; other site
754476004008	ABC transporter signature motif; other site
754476004009	Walker B; other site
754476004010	D-loop; other site
754476004011	H-loop/switch region; other site
754476004012	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
754476004013	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
754476004014	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
754476004015	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
754476004016	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476004017	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
754476004018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476004019	Walker A motif; other site
754476004020	ATP binding site [chemical binding]; other site
754476004021	Walker B motif; other site
754476004022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476004023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476004024	dimer interface [polypeptide binding]; other site
754476004025	phosphorylation site [posttranslational modification]
754476004026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476004027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004028	active site
754476004029	phosphorylation site [posttranslational modification]
754476004030	intermolecular recognition site; other site
754476004031	dimerization interface [polypeptide binding]; other site
754476004032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476004033	DNA binding site [nucleotide binding]
754476004034	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
754476004035	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476004036	Outer membrane efflux protein; Region: OEP; pfam02321
754476004037	Outer membrane efflux protein; Region: OEP; pfam02321
754476004038	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
754476004039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476004040	putative substrate translocation pore; other site
754476004041	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
754476004042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476004043	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
754476004044	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
754476004045	Sulfate transporter family; Region: Sulfate_transp; pfam00916
754476004046	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
754476004047	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
754476004048	Ligand Binding Site [chemical binding]; other site
754476004049	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
754476004050	Ligand Binding Site [chemical binding]; other site
754476004051	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
754476004052	PAS fold; Region: PAS_2; pfam08446
754476004053	GAF domain; Region: GAF; pfam01590
754476004054	Phytochrome region; Region: PHY; pfam00360
754476004055	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476004056	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476004057	metal binding site [ion binding]; metal-binding site
754476004058	active site
754476004059	I-site; other site
754476004060	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
754476004061	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
754476004062	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
754476004063	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
754476004064	G1 box; other site
754476004065	putative GEF interaction site [polypeptide binding]; other site
754476004066	GTP/Mg2+ binding site [chemical binding]; other site
754476004067	Switch I region; other site
754476004068	G2 box; other site
754476004069	G3 box; other site
754476004070	Switch II region; other site
754476004071	G4 box; other site
754476004072	G5 box; other site
754476004073	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
754476004074	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
754476004075	FOG: CBS domain [General function prediction only]; Region: COG0517
754476004076	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
754476004077	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
754476004078	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
754476004079	active site
754476004080	HIGH motif; other site
754476004081	nucleotide binding site [chemical binding]; other site
754476004082	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
754476004083	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
754476004084	active site
754476004085	KMSKS motif; other site
754476004086	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
754476004087	tRNA binding surface [nucleotide binding]; other site
754476004088	anticodon binding site; other site
754476004089	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
754476004090	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
754476004091	lipoprotein signal peptidase; Provisional; Region: PRK14787
754476004092	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
754476004093	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476004094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004095	homodimer interface [polypeptide binding]; other site
754476004096	catalytic residue [active]
754476004097	prephenate dehydrogenase; Validated; Region: PRK08507
754476004098	Prephenate dehydrogenase; Region: PDH; pfam02153
754476004099	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
754476004100	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
754476004101	hinge; other site
754476004102	active site
754476004103	cytidylate kinase; Provisional; Region: cmk; PRK00023
754476004104	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
754476004105	CMP-binding site; other site
754476004106	The sites determining sugar specificity; other site
754476004107	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
754476004108	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
754476004109	RNA binding site [nucleotide binding]; other site
754476004110	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
754476004111	RNA binding site [nucleotide binding]; other site
754476004112	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
754476004113	RNA binding site [nucleotide binding]; other site
754476004114	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
754476004115	RNA binding site [nucleotide binding]; other site
754476004116	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
754476004117	RNA binding site [nucleotide binding]; other site
754476004118	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
754476004119	RNA binding site [nucleotide binding]; other site
754476004120	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
754476004121	IHF dimer interface [polypeptide binding]; other site
754476004122	IHF - DNA interface [nucleotide binding]; other site
754476004123	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
754476004124	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
754476004125	Low-spin heme binding site [chemical binding]; other site
754476004126	Putative water exit pathway; other site
754476004127	Binuclear center (active site) [active]
754476004128	K-pathway; other site
754476004129	Putative proton exit pathway; other site
754476004130	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
754476004131	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
754476004132	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
754476004133	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
754476004134	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
754476004135	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
754476004136	FixH; Region: FixH; pfam05751
754476004137	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
754476004138	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
754476004139	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
754476004140	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
754476004141	putative ligand binding site [chemical binding]; other site
754476004142	HAMP domain; Region: HAMP; pfam00672
754476004143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476004144	PAS domain; Region: PAS_9; pfam13426
754476004145	putative active site [active]
754476004146	heme pocket [chemical binding]; other site
754476004147	PAS domain; Region: PAS_9; pfam13426
754476004148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476004149	putative active site [active]
754476004150	heme pocket [chemical binding]; other site
754476004151	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476004152	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476004153	metal binding site [ion binding]; metal-binding site
754476004154	active site
754476004155	I-site; other site
754476004156	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476004157	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
754476004158	putative active site [active]
754476004159	dimerization interface [polypeptide binding]; other site
754476004160	putative tRNAtyr binding site [nucleotide binding]; other site
754476004161	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
754476004162	PGAP1-like protein; Region: PGAP1; pfam07819
754476004163	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
754476004164	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
754476004165	CoA-ligase; Region: Ligase_CoA; pfam00549
754476004166	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
754476004167	CoA binding domain; Region: CoA_binding; smart00881
754476004168	CoA-ligase; Region: Ligase_CoA; pfam00549
754476004169	NAD synthetase; Provisional; Region: PRK13981
754476004170	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
754476004171	multimer interface [polypeptide binding]; other site
754476004172	active site
754476004173	catalytic triad [active]
754476004174	protein interface 1 [polypeptide binding]; other site
754476004175	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
754476004176	homodimer interface [polypeptide binding]; other site
754476004177	NAD binding pocket [chemical binding]; other site
754476004178	ATP binding pocket [chemical binding]; other site
754476004179	Mg binding site [ion binding]; other site
754476004180	active-site loop [active]
754476004181	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
754476004182	Nitrogen regulatory protein P-II; Region: P-II; smart00938
754476004183	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
754476004184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
754476004185	binding surface
754476004186	TPR motif; other site
754476004187	L,D-transpeptidase; Provisional; Region: PRK10260
754476004188	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
754476004189	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
754476004190	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
754476004191	active site
754476004192	dimerization interface [polypeptide binding]; other site
754476004193	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
754476004194	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
754476004195	G1 box; other site
754476004196	putative GEF interaction site [polypeptide binding]; other site
754476004197	GTP/Mg2+ binding site [chemical binding]; other site
754476004198	Switch I region; other site
754476004199	G2 box; other site
754476004200	G3 box; other site
754476004201	Switch II region; other site
754476004202	G4 box; other site
754476004203	G5 box; other site
754476004204	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
754476004205	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
754476004206	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
754476004207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476004208	dimer interface [polypeptide binding]; other site
754476004209	phosphorylation site [posttranslational modification]
754476004210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004211	ATP binding site [chemical binding]; other site
754476004212	Mg2+ binding site [ion binding]; other site
754476004213	G-X-G motif; other site
754476004214	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476004215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004216	active site
754476004217	phosphorylation site [posttranslational modification]
754476004218	intermolecular recognition site; other site
754476004219	dimerization interface [polypeptide binding]; other site
754476004220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476004221	Walker A motif; other site
754476004222	ATP binding site [chemical binding]; other site
754476004223	Walker B motif; other site
754476004224	arginine finger; other site
754476004225	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476004226	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
754476004227	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
754476004228	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
754476004229	L-aspartate oxidase; Provisional; Region: PRK09077
754476004230	L-aspartate oxidase; Provisional; Region: PRK06175
754476004231	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
754476004232	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
754476004233	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476004234	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476004235	DNA binding residues [nucleotide binding]
754476004236	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
754476004237	anti-sigma E factor; Provisional; Region: rseB; PRK09455
754476004238	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
754476004239	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
754476004240	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
754476004241	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
754476004242	protein binding site [polypeptide binding]; other site
754476004243	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
754476004244	protein binding site [polypeptide binding]; other site
754476004245	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476004246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004247	active site
754476004248	phosphorylation site [posttranslational modification]
754476004249	intermolecular recognition site; other site
754476004250	dimerization interface [polypeptide binding]; other site
754476004251	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476004252	DNA binding site [nucleotide binding]
754476004253	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476004254	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476004255	dimerization interface [polypeptide binding]; other site
754476004256	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476004257	dimer interface [polypeptide binding]; other site
754476004258	phosphorylation site [posttranslational modification]
754476004259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004260	ATP binding site [chemical binding]; other site
754476004261	Mg2+ binding site [ion binding]; other site
754476004262	G-X-G motif; other site
754476004263	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
754476004264	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476004265	N-terminal plug; other site
754476004266	ligand-binding site [chemical binding]; other site
754476004267	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
754476004268	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
754476004269	GTP-binding protein LepA; Provisional; Region: PRK05433
754476004270	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
754476004271	G1 box; other site
754476004272	putative GEF interaction site [polypeptide binding]; other site
754476004273	GTP/Mg2+ binding site [chemical binding]; other site
754476004274	Switch I region; other site
754476004275	G2 box; other site
754476004276	G3 box; other site
754476004277	Switch II region; other site
754476004278	G4 box; other site
754476004279	G5 box; other site
754476004280	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
754476004281	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
754476004282	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
754476004283	signal peptidase I; Provisional; Region: PRK10861
754476004284	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
754476004285	Catalytic site [active]
754476004286	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
754476004287	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
754476004288	ribonuclease III; Reviewed; Region: rnc; PRK00102
754476004289	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
754476004290	dimerization interface [polypeptide binding]; other site
754476004291	active site
754476004292	metal binding site [ion binding]; metal-binding site
754476004293	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
754476004294	dsRNA binding site [nucleotide binding]; other site
754476004295	GTPase Era; Reviewed; Region: era; PRK00089
754476004296	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
754476004297	G1 box; other site
754476004298	GTP/Mg2+ binding site [chemical binding]; other site
754476004299	Switch I region; other site
754476004300	G2 box; other site
754476004301	Switch II region; other site
754476004302	G3 box; other site
754476004303	G4 box; other site
754476004304	G5 box; other site
754476004305	KH domain; Region: KH_2; pfam07650
754476004306	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
754476004307	Recombination protein O N terminal; Region: RecO_N; pfam11967
754476004308	Recombination protein O C terminal; Region: RecO_C; pfam02565
754476004309	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
754476004310	active site
754476004311	hydrophilic channel; other site
754476004312	dimerization interface [polypeptide binding]; other site
754476004313	catalytic residues [active]
754476004314	active site lid [active]
754476004315	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
754476004316	cysteine synthase B; Region: cysM; TIGR01138
754476004317	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
754476004318	dimer interface [polypeptide binding]; other site
754476004319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004320	catalytic residue [active]
754476004321	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
754476004322	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
754476004323	TRAM domain; Region: TRAM; pfam01938
754476004324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476004325	S-adenosylmethionine binding site [chemical binding]; other site
754476004326	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
754476004327	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
754476004328	phosphoenolpyruvate synthase; Validated; Region: PRK06464
754476004329	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
754476004330	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
754476004331	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
754476004332	PEP synthetase regulatory protein; Provisional; Region: PRK05339
754476004333	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
754476004334	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
754476004335	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
754476004336	active site
754476004337	tetramer interface; other site
754476004338	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
754476004339	PQQ-like domain; Region: PQQ_2; pfam13360
754476004340	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
754476004341	active site
754476004342	Trp docking motif [polypeptide binding]; other site
754476004343	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
754476004344	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
754476004345	active site
754476004346	tetramer interface; other site
754476004347	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
754476004348	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
754476004349	NAD binding site [chemical binding]; other site
754476004350	homodimer interface [polypeptide binding]; other site
754476004351	active site
754476004352	substrate binding site [chemical binding]; other site
754476004353	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
754476004354	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
754476004355	Substrate binding site; other site
754476004356	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
754476004357	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
754476004358	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
754476004359	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
754476004360	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
754476004361	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
754476004362	Chain length determinant protein; Region: Wzz; cl15801
754476004363	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
754476004364	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
754476004365	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
754476004366	AAA domain; Region: AAA_22; pfam13401
754476004367	AAA ATPase domain; Region: AAA_16; pfam13191
754476004368	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
754476004369	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
754476004370	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
754476004371	active site
754476004372	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
754476004373	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
754476004374	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
754476004375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004376	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
754476004377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476004378	NAD(P) binding site [chemical binding]; other site
754476004379	active site
754476004380	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
754476004381	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004382	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
754476004383	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
754476004384	Probable Catalytic site; other site
754476004385	metal-binding site
754476004386	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
754476004387	sulfotransferase; Region: PLN02164
754476004388	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
754476004389	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
754476004390	trimer interface [polypeptide binding]; other site
754476004391	active site
754476004392	substrate binding site [chemical binding]; other site
754476004393	CoA binding site [chemical binding]; other site
754476004394	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
754476004395	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
754476004396	active site
754476004397	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
754476004398	hypothetical protein; Validated; Region: PRK08238
754476004399	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
754476004400	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
754476004401	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
754476004402	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
754476004403	active site
754476004404	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
754476004405	putative ADP-binding pocket [chemical binding]; other site
754476004406	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004407	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
754476004408	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
754476004409	active site
754476004410	dimer interface [polypeptide binding]; other site
754476004411	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
754476004412	Ligand Binding Site [chemical binding]; other site
754476004413	Molecular Tunnel; other site
754476004414	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
754476004415	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
754476004416	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
754476004417	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
754476004418	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
754476004419	Chain length determinant protein; Region: Wzz; cl15801
754476004420	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
754476004421	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
754476004422	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
754476004423	O-Antigen ligase; Region: Wzy_C; pfam04932
754476004424	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
754476004425	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
754476004426	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
754476004427	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004428	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
754476004429	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
754476004430	putative trimer interface [polypeptide binding]; other site
754476004431	putative CoA binding site [chemical binding]; other site
754476004432	serine O-acetyltransferase; Region: cysE; TIGR01172
754476004433	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
754476004434	trimer interface [polypeptide binding]; other site
754476004435	active site
754476004436	substrate binding site [chemical binding]; other site
754476004437	CoA binding site [chemical binding]; other site
754476004438	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
754476004439	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
754476004440	Probable Catalytic site; other site
754476004441	metal-binding site
754476004442	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004443	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
754476004444	Methyltransferase domain; Region: Methyltransf_31; pfam13847
754476004445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476004446	S-adenosylmethionine binding site [chemical binding]; other site
754476004447	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
754476004448	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
754476004449	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
754476004450	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476004451	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
754476004452	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
754476004453	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
754476004454	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
754476004455	anti sigma factor interaction site; other site
754476004456	regulatory phosphorylation site [posttranslational modification]; other site
754476004457	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
754476004458	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
754476004459	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
754476004460	TPR repeat; Region: TPR_11; pfam13414
754476004461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004462	TPR motif; other site
754476004463	TPR repeat; Region: TPR_11; pfam13414
754476004464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004465	binding surface
754476004466	TPR motif; other site
754476004467	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
754476004468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004469	TPR motif; other site
754476004470	binding surface
754476004471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004472	TPR motif; other site
754476004473	binding surface
754476004474	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
754476004475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004476	TPR motif; other site
754476004477	binding surface
754476004478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004479	binding surface
754476004480	TPR motif; other site
754476004481	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
754476004482	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476004483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476004484	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
754476004485	putative dimerization interface [polypeptide binding]; other site
754476004486	pyruvate carboxylase subunit A; Validated; Region: PRK07178
754476004487	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
754476004488	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
754476004489	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
754476004490	pyruvate carboxylase subunit B; Validated; Region: PRK09282
754476004491	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
754476004492	active site
754476004493	catalytic residues [active]
754476004494	metal binding site [ion binding]; metal-binding site
754476004495	homodimer binding site [polypeptide binding]; other site
754476004496	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
754476004497	carboxyltransferase (CT) interaction site; other site
754476004498	biotinylation site [posttranslational modification]; other site
754476004499	Acyltransferase family; Region: Acyl_transf_3; pfam01757
754476004500	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
754476004501	cystathionine beta-lyase; Provisional; Region: PRK07671
754476004502	homodimer interface [polypeptide binding]; other site
754476004503	substrate-cofactor binding pocket; other site
754476004504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004505	catalytic residue [active]
754476004506	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14263
754476004507	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
754476004508	Walker A/P-loop; other site
754476004509	ATP binding site [chemical binding]; other site
754476004510	Q-loop/lid; other site
754476004511	ABC transporter signature motif; other site
754476004512	Walker B; other site
754476004513	D-loop; other site
754476004514	H-loop/switch region; other site
754476004515	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
754476004516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476004517	dimer interface [polypeptide binding]; other site
754476004518	conserved gate region; other site
754476004519	putative PBP binding loops; other site
754476004520	ABC-ATPase subunit interface; other site
754476004521	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
754476004522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476004523	dimer interface [polypeptide binding]; other site
754476004524	conserved gate region; other site
754476004525	putative PBP binding loops; other site
754476004526	ABC-ATPase subunit interface; other site
754476004527	PBP superfamily domain; Region: PBP_like_2; cl17296
754476004528	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476004529	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
754476004530	Trp docking motif [polypeptide binding]; other site
754476004531	dimer interface [polypeptide binding]; other site
754476004532	active site
754476004533	small subunit binding site [polypeptide binding]; other site
754476004534	aspartate aminotransferase; Provisional; Region: PRK05764
754476004535	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476004536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004537	homodimer interface [polypeptide binding]; other site
754476004538	catalytic residue [active]
754476004539	excinuclease ABC subunit B; Provisional; Region: PRK05298
754476004540	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476004541	ATP binding site [chemical binding]; other site
754476004542	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476004543	nucleotide binding region [chemical binding]; other site
754476004544	ATP-binding site [chemical binding]; other site
754476004545	Ultra-violet resistance protein B; Region: UvrB; pfam12344
754476004546	UvrB/uvrC motif; Region: UVR; pfam02151
754476004547	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
754476004548	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
754476004549	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
754476004550	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
754476004551	active site
754476004552	dimer interface [polypeptide binding]; other site
754476004553	motif 1; other site
754476004554	motif 2; other site
754476004555	motif 3; other site
754476004556	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
754476004557	anticodon binding site; other site
754476004558	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
754476004559	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
754476004560	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
754476004561	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
754476004562	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
754476004563	23S rRNA binding site [nucleotide binding]; other site
754476004564	L21 binding site [polypeptide binding]; other site
754476004565	L13 binding site [polypeptide binding]; other site
754476004566	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
754476004567	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
754476004568	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
754476004569	dimer interface [polypeptide binding]; other site
754476004570	motif 1; other site
754476004571	active site
754476004572	motif 2; other site
754476004573	motif 3; other site
754476004574	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
754476004575	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
754476004576	putative tRNA-binding site [nucleotide binding]; other site
754476004577	B3/4 domain; Region: B3_4; pfam03483
754476004578	tRNA synthetase B5 domain; Region: B5; smart00874
754476004579	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
754476004580	dimer interface [polypeptide binding]; other site
754476004581	motif 1; other site
754476004582	motif 3; other site
754476004583	motif 2; other site
754476004584	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
754476004585	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
754476004586	IHF dimer interface [polypeptide binding]; other site
754476004587	IHF - DNA interface [nucleotide binding]; other site
754476004588	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
754476004589	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
754476004590	DNA binding residues [nucleotide binding]
754476004591	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
754476004592	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
754476004593	active site
754476004594	catalytic tetrad [active]
754476004595	Response regulator receiver domain; Region: Response_reg; pfam00072
754476004596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004597	active site
754476004598	phosphorylation site [posttranslational modification]
754476004599	intermolecular recognition site; other site
754476004600	dimerization interface [polypeptide binding]; other site
754476004601	PAS fold; Region: PAS_3; pfam08447
754476004602	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
754476004603	heme pocket [chemical binding]; other site
754476004604	putative active site [active]
754476004605	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476004606	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476004607	metal binding site [ion binding]; metal-binding site
754476004608	active site
754476004609	I-site; other site
754476004610	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476004611	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
754476004612	MarR family; Region: MarR; pfam01047
754476004613	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476004614	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
754476004615	Coenzyme A binding pocket [chemical binding]; other site
754476004616	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
754476004617	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
754476004618	inhibitor-cofactor binding pocket; inhibition site
754476004619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004620	catalytic residue [active]
754476004621	Ectoine synthase; Region: Ectoine_synth; pfam06339
754476004622	aspartate kinase; Validated; Region: PRK09181
754476004623	AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248
754476004624	putative catalytic residues [active]
754476004625	putative nucleotide binding site [chemical binding]; other site
754476004626	putative aspartate binding site [chemical binding]; other site
754476004627	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910
754476004628	allosteric regulatory residue; other site
754476004629	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915
754476004630	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
754476004631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004632	TPR motif; other site
754476004633	TPR repeat; Region: TPR_11; pfam13414
754476004634	binding surface
754476004635	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476004636	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476004637	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476004638	Fatty acid desaturase; Region: FA_desaturase; pfam00487
754476004639	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
754476004640	Di-iron ligands [ion binding]; other site
754476004641	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
754476004642	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
754476004643	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
754476004644	hydroxyglutarate oxidase; Provisional; Region: PRK11728
754476004645	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
754476004646	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
754476004647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476004648	S-adenosylmethionine binding site [chemical binding]; other site
754476004649	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
754476004650	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
754476004651	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
754476004652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476004653	S-adenosylmethionine binding site [chemical binding]; other site
754476004654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476004655	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
754476004656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476004657	dimer interface [polypeptide binding]; other site
754476004658	phosphorylation site [posttranslational modification]
754476004659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004660	ATP binding site [chemical binding]; other site
754476004661	Mg2+ binding site [ion binding]; other site
754476004662	G-X-G motif; other site
754476004663	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476004664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004665	active site
754476004666	phosphorylation site [posttranslational modification]
754476004667	intermolecular recognition site; other site
754476004668	dimerization interface [polypeptide binding]; other site
754476004669	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476004670	DNA binding site [nucleotide binding]
754476004671	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
754476004672	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
754476004673	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
754476004674	heme binding site [chemical binding]; other site
754476004675	ferroxidase pore; other site
754476004676	ferroxidase diiron center [ion binding]; other site
754476004677	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
754476004678	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
754476004679	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
754476004680	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
754476004681	serine O-acetyltransferase; Region: cysE; TIGR01172
754476004682	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
754476004683	trimer interface [polypeptide binding]; other site
754476004684	active site
754476004685	substrate binding site [chemical binding]; other site
754476004686	CoA binding site [chemical binding]; other site
754476004687	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
754476004688	Rrf2 family protein; Region: rrf2_super; TIGR00738
754476004689	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
754476004690	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
754476004691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
754476004692	catalytic residue [active]
754476004693	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
754476004694	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
754476004695	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
754476004696	inhibitor-cofactor binding pocket; inhibition site
754476004697	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476004698	catalytic residue [active]
754476004699	peroxiredoxin; Region: AhpC; TIGR03137
754476004700	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
754476004701	dimer interface [polypeptide binding]; other site
754476004702	decamer (pentamer of dimers) interface [polypeptide binding]; other site
754476004703	catalytic triad [active]
754476004704	peroxidatic and resolving cysteines [active]
754476004705	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
754476004706	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
754476004707	catalytic residue [active]
754476004708	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
754476004709	catalytic residues [active]
754476004710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
754476004711	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476004712	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476004713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004714	active site
754476004715	phosphorylation site [posttranslational modification]
754476004716	intermolecular recognition site; other site
754476004717	dimerization interface [polypeptide binding]; other site
754476004718	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476004719	DNA binding residues [nucleotide binding]
754476004720	dimerization interface [polypeptide binding]; other site
754476004721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
754476004722	Histidine kinase; Region: HisKA_3; pfam07730
754476004723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004724	ATP binding site [chemical binding]; other site
754476004725	Mg2+ binding site [ion binding]; other site
754476004726	G-X-G motif; other site
754476004727	MoxR-like ATPases [General function prediction only]; Region: COG0714
754476004728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
754476004729	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
754476004730	metal ion-dependent adhesion site (MIDAS); other site
754476004731	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
754476004732	TPP-binding site [chemical binding]; other site
754476004733	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
754476004734	von Willebrand factor type A domain; Region: VWA_2; pfam13519
754476004735	metal ion-dependent adhesion site (MIDAS); other site
754476004736	Bacteriophage holin; Region: Phage_holin_1; cl02344
754476004737	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
754476004738	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
754476004739	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
754476004740	beta-hexosaminidase; Provisional; Region: PRK05337
754476004741	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
754476004742	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
754476004743	putative active site [active]
754476004744	putative PHP Thumb interface [polypeptide binding]; other site
754476004745	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
754476004746	generic binding surface I; other site
754476004747	generic binding surface II; other site
754476004748	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
754476004749	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
754476004750	Walker A motif; other site
754476004751	ATP binding site [chemical binding]; other site
754476004752	Walker B motif; other site
754476004753	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
754476004754	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
754476004755	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
754476004756	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
754476004757	Ligand Binding Site [chemical binding]; other site
754476004758	TilS substrate binding domain; Region: TilS; pfam09179
754476004759	TilS substrate C-terminal domain; Region: TilS_C; smart00977
754476004760	CTP synthetase; Validated; Region: pyrG; PRK05380
754476004761	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
754476004762	Catalytic site [active]
754476004763	active site
754476004764	UTP binding site [chemical binding]; other site
754476004765	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
754476004766	active site
754476004767	putative oxyanion hole; other site
754476004768	catalytic triad [active]
754476004769	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
754476004770	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
754476004771	enolase; Provisional; Region: eno; PRK00077
754476004772	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
754476004773	dimer interface [polypeptide binding]; other site
754476004774	metal binding site [ion binding]; metal-binding site
754476004775	substrate binding pocket [chemical binding]; other site
754476004776	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
754476004777	Septum formation initiator; Region: DivIC; cl17659
754476004778	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
754476004779	substrate binding site; other site
754476004780	dimer interface; other site
754476004781	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
754476004782	homotrimer interaction site [polypeptide binding]; other site
754476004783	zinc binding site [ion binding]; other site
754476004784	CDP-binding sites; other site
754476004785	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
754476004786	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
754476004787	Permutation of conserved domain; other site
754476004788	active site
754476004789	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cd01291
754476004790	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
754476004791	siroheme synthase; Provisional; Region: cysG; PRK10637
754476004792	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
754476004793	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
754476004794	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
754476004795	active site
754476004796	SAM binding site [chemical binding]; other site
754476004797	homodimer interface [polypeptide binding]; other site
754476004798	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476004799	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476004800	N-terminal plug; other site
754476004801	ligand-binding site [chemical binding]; other site
754476004802	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
754476004803	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
754476004804	dimerization interface [polypeptide binding]; other site
754476004805	active site
754476004806	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
754476004807	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
754476004808	amidase catalytic site [active]
754476004809	Zn binding residues [ion binding]; other site
754476004810	substrate binding site [chemical binding]; other site
754476004811	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
754476004812	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
754476004813	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
754476004814	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
754476004815	Transcriptional regulator; Region: Rrf2; pfam02082
754476004816	Transcriptional regulator; Region: Rrf2; cl17282
754476004817	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
754476004818	putative ABC transporter; Region: ycf24; CHL00085
754476004819	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
754476004820	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
754476004821	Walker A/P-loop; other site
754476004822	ATP binding site [chemical binding]; other site
754476004823	Q-loop/lid; other site
754476004824	ABC transporter signature motif; other site
754476004825	Walker B; other site
754476004826	D-loop; other site
754476004827	H-loop/switch region; other site
754476004828	FeS assembly protein SufD; Region: sufD; TIGR01981
754476004829	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
754476004830	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
754476004831	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
754476004832	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
754476004833	catalytic residue [active]
754476004834	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
754476004835	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
754476004836	trimerization site [polypeptide binding]; other site
754476004837	active site
754476004838	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
754476004839	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
754476004840	O-Antigen ligase; Region: Wzy_C; pfam04932
754476004841	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
754476004842	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
754476004843	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
754476004844	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
754476004845	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
754476004846	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
754476004847	Walker A motif; other site
754476004848	ATP binding site [chemical binding]; other site
754476004849	Walker B motif; other site
754476004850	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
754476004851	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476004852	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476004853	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
754476004854	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
754476004855	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
754476004856	Protein of unknown function (DUF3438); Region: DUF3438; cl13372
754476004857	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476004858	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476004859	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
754476004860	Histidine kinase; Region: HisKA_3; pfam07730
754476004861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004862	ATP binding site [chemical binding]; other site
754476004863	Mg2+ binding site [ion binding]; other site
754476004864	G-X-G motif; other site
754476004865	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476004866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004867	active site
754476004868	phosphorylation site [posttranslational modification]
754476004869	intermolecular recognition site; other site
754476004870	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476004871	DNA binding residues [nucleotide binding]
754476004872	dimerization interface [polypeptide binding]; other site
754476004873	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
754476004874	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
754476004875	putative dimer interface [polypeptide binding]; other site
754476004876	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
754476004877	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
754476004878	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
754476004879	active site
754476004880	HIGH motif; other site
754476004881	KMSKS motif; other site
754476004882	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
754476004883	tRNA binding surface [nucleotide binding]; other site
754476004884	anticodon binding site; other site
754476004885	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
754476004886	dimer interface [polypeptide binding]; other site
754476004887	putative tRNA-binding site [nucleotide binding]; other site
754476004888	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
754476004889	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
754476004890	putative Iron-sulfur protein interface [polypeptide binding]; other site
754476004891	proximal heme binding site [chemical binding]; other site
754476004892	distal heme binding site [chemical binding]; other site
754476004893	putative dimer interface [polypeptide binding]; other site
754476004894	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
754476004895	L-aspartate oxidase; Provisional; Region: PRK06175
754476004896	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
754476004897	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
754476004898	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
754476004899	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
754476004900	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
754476004901	Domain of unknown function (DUF389); Region: DUF389; pfam04087
754476004902	Predicted methyltransferase [General function prediction only]; Region: COG4798
754476004903	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476004904	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
754476004905	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
754476004906	putative ADP-binding pocket [chemical binding]; other site
754476004907	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
754476004908	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
754476004909	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
754476004910	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
754476004911	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
754476004912	putative substrate binding site [chemical binding]; other site
754476004913	putative ATP binding site [chemical binding]; other site
754476004914	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
754476004915	trehalose synthase; Region: treS_nterm; TIGR02456
754476004916	active site
754476004917	catalytic site [active]
754476004918	Protein of unknown function, DUF393; Region: DUF393; pfam04134
754476004919	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
754476004920	DNA photolyase; Region: DNA_photolyase; pfam00875
754476004921	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
754476004922	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
754476004923	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476004924	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476004925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476004926	PAS fold; Region: PAS_3; pfam08447
754476004927	putative active site [active]
754476004928	heme pocket [chemical binding]; other site
754476004929	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476004930	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476004931	metal binding site [ion binding]; metal-binding site
754476004932	active site
754476004933	I-site; other site
754476004934	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
754476004935	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
754476004936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476004937	FeS/SAM binding site; other site
754476004938	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
754476004939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476004940	active site
754476004941	motif I; other site
754476004942	motif II; other site
754476004943	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476004944	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
754476004945	putative ligand binding pocket/active site [active]
754476004946	putative metal binding site [ion binding]; other site
754476004947	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
754476004948	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476004949	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476004950	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
754476004951	putative effector binding pocket; other site
754476004952	dimerization interface [polypeptide binding]; other site
754476004953	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
754476004954	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
754476004955	Pirin-related protein [General function prediction only]; Region: COG1741
754476004956	Pirin; Region: Pirin; pfam02678
754476004957	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
754476004958	periplasmic protein; Provisional; Region: PRK10568
754476004959	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
754476004960	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
754476004961	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
754476004962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476004963	active site
754476004964	phosphorylation site [posttranslational modification]
754476004965	intermolecular recognition site; other site
754476004966	dimerization interface [polypeptide binding]; other site
754476004967	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476004968	DNA binding site [nucleotide binding]
754476004969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476004970	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476004971	dimer interface [polypeptide binding]; other site
754476004972	phosphorylation site [posttranslational modification]
754476004973	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476004974	ATP binding site [chemical binding]; other site
754476004975	Mg2+ binding site [ion binding]; other site
754476004976	G-X-G motif; other site
754476004977	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
754476004978	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
754476004979	hexamer interface [polypeptide binding]; other site
754476004980	ligand binding site [chemical binding]; other site
754476004981	putative active site [active]
754476004982	NAD(P) binding site [chemical binding]; other site
754476004983	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
754476004984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004985	binding surface
754476004986	TPR repeat; Region: TPR_11; pfam13414
754476004987	TPR motif; other site
754476004988	Tetratricopeptide repeat; Region: TPR_12; pfam13424
754476004989	Tetratricopeptide repeat; Region: TPR_17; pfam13431
754476004990	TPR repeat; Region: TPR_11; pfam13414
754476004991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476004992	binding surface
754476004993	TPR motif; other site
754476004994	Tetratricopeptide repeat; Region: TPR_16; pfam13432
754476004995	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
754476004996	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
754476004997	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
754476004998	catalytic triad [active]
754476004999	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
754476005000	dihydrodipicolinate synthase; Region: dapA; TIGR00674
754476005001	dimer interface [polypeptide binding]; other site
754476005002	active site
754476005003	catalytic residue [active]
754476005004	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
754476005005	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
754476005006	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
754476005007	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
754476005008	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
754476005009	ATP binding site [chemical binding]; other site
754476005010	active site
754476005011	substrate binding site [chemical binding]; other site
754476005012	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
754476005013	O-Antigen ligase; Region: Wzy_C; pfam04932
754476005014	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
754476005015	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
754476005016	Pilin (bacterial filament); Region: Pilin; pfam00114
754476005017	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
754476005018	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
754476005019	RimK-like ATP-grasp domain; Region: RimK; pfam08443
754476005020	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
754476005021	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
754476005022	putative active site [active]
754476005023	Zn binding site [ion binding]; other site
754476005024	arginine decarboxylase; Provisional; Region: PRK05354
754476005025	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
754476005026	dimer interface [polypeptide binding]; other site
754476005027	active site
754476005028	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
754476005029	catalytic residues [active]
754476005030	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
754476005031	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
754476005032	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
754476005033	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
754476005034	dimer interface [polypeptide binding]; other site
754476005035	active site
754476005036	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
754476005037	catalytic residues [active]
754476005038	substrate binding site [chemical binding]; other site
754476005039	agmatinase; Region: agmatinase; TIGR01230
754476005040	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
754476005041	putative active site [active]
754476005042	Mn binding site [ion binding]; other site
754476005043	conserved hypothetical protein, steroid delta-isomerase-related; Region: TIGR02096
754476005044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476005045	Coenzyme A binding pocket [chemical binding]; other site
754476005046	Predicted amidohydrolase [General function prediction only]; Region: COG0388
754476005047	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
754476005048	putative active site [active]
754476005049	catalytic triad [active]
754476005050	putative dimer interface [polypeptide binding]; other site
754476005051	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
754476005052	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
754476005053	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
754476005054	trimer interface [polypeptide binding]; other site
754476005055	active site
754476005056	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
754476005057	structural tetrad; other site
754476005058	FOG: WD40 repeat [General function prediction only]; Region: COG2319
754476005059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
754476005060	aminopeptidase N; Provisional; Region: pepN; PRK14015
754476005061	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
754476005062	active site
754476005063	Zn binding site [ion binding]; other site
754476005064	HIT domain; Region: HIT; pfam01230
754476005065	nucleotide binding site/active site [active]
754476005066	HIT family signature motif; other site
754476005067	catalytic residue [active]
754476005068	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
754476005069	RDD family; Region: RDD; pfam06271
754476005070	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
754476005071	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
754476005072	dimerization interface [polypeptide binding]; other site
754476005073	ATP binding site [chemical binding]; other site
754476005074	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
754476005075	dimerization interface [polypeptide binding]; other site
754476005076	ATP binding site [chemical binding]; other site
754476005077	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
754476005078	putative active site [active]
754476005079	catalytic triad [active]
754476005080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005082	metal binding site [ion binding]; metal-binding site
754476005083	active site
754476005084	I-site; other site
754476005085	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005086	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005087	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
754476005088	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476005089	dimerization interface [polypeptide binding]; other site
754476005090	PAS domain S-box; Region: sensory_box; TIGR00229
754476005091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476005092	putative active site [active]
754476005093	heme pocket [chemical binding]; other site
754476005094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005096	metal binding site [ion binding]; metal-binding site
754476005097	active site
754476005098	I-site; other site
754476005099	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476005100	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
754476005101	MASE1; Region: MASE1; cl17823
754476005102	MASE1; Region: MASE1; cl17823
754476005103	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005105	metal binding site [ion binding]; metal-binding site
754476005106	active site
754476005107	I-site; other site
754476005108	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
754476005109	Cache domain; Region: Cache_1; pfam02743
754476005110	PAS domain S-box; Region: sensory_box; TIGR00229
754476005111	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005112	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005113	metal binding site [ion binding]; metal-binding site
754476005114	active site
754476005115	I-site; other site
754476005116	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
754476005117	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
754476005118	Low-spin heme binding site [chemical binding]; other site
754476005119	Putative water exit pathway; other site
754476005120	Binuclear center (active site) [active]
754476005121	Putative proton exit pathway; other site
754476005122	FOG: CBS domain [General function prediction only]; Region: COG0517
754476005123	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
754476005124	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
754476005125	dinuclear metal binding motif [ion binding]; other site
754476005126	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
754476005127	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
754476005128	Ion channel; Region: Ion_trans_2; pfam07885
754476005129	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
754476005130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476005131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476005132	DNA binding residues [nucleotide binding]
754476005133	fec operon regulator FecR; Reviewed; Region: PRK09774
754476005134	FecR protein; Region: FecR; pfam04773
754476005135	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476005136	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476005137	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
754476005138	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476005139	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476005140	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
754476005141	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
754476005142	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
754476005143	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
754476005144	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
754476005145	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476005146	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
754476005147	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
754476005148	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
754476005149	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
754476005150	Walker A motif; other site
754476005151	ATP binding site [chemical binding]; other site
754476005152	Walker B motif; other site
754476005153	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
754476005154	Secretin and TonB N terminus short domain; Region: STN; smart00965
754476005155	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
754476005156	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
754476005157	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
754476005158	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
754476005159	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
754476005160	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
754476005161	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
754476005162	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476005163	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
754476005164	Walker A/P-loop; other site
754476005165	ATP binding site [chemical binding]; other site
754476005166	Q-loop/lid; other site
754476005167	ABC transporter signature motif; other site
754476005168	Walker B; other site
754476005169	D-loop; other site
754476005170	H-loop/switch region; other site
754476005171	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
754476005172	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476005173	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
754476005174	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476005175	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476005176	TolR protein; Region: tolR; TIGR02801
754476005177	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476005178	Protein of unknown function, DUF488; Region: DUF488; cl01246
754476005179	carbon storage regulator; Provisional; Region: PRK01712
754476005180	aspartate kinase; Reviewed; Region: PRK06635
754476005181	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
754476005182	putative nucleotide binding site [chemical binding]; other site
754476005183	putative catalytic residues [active]
754476005184	putative Mg ion binding site [ion binding]; other site
754476005185	putative aspartate binding site [chemical binding]; other site
754476005186	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
754476005187	putative allosteric regulatory site; other site
754476005188	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
754476005189	putative allosteric regulatory residue; other site
754476005190	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
754476005191	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
754476005192	motif 1; other site
754476005193	active site
754476005194	motif 2; other site
754476005195	motif 3; other site
754476005196	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
754476005197	DHHA1 domain; Region: DHHA1; pfam02272
754476005198	recombination regulator RecX; Reviewed; Region: recX; PRK00117
754476005199	recombinase A; Provisional; Region: recA; PRK09354
754476005200	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
754476005201	hexamer interface [polypeptide binding]; other site
754476005202	Walker A motif; other site
754476005203	ATP binding site [chemical binding]; other site
754476005204	Walker B motif; other site
754476005205	Competence-damaged protein; Region: CinA; pfam02464
754476005206	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
754476005207	MutS domain I; Region: MutS_I; pfam01624
754476005208	MutS domain II; Region: MutS_II; pfam05188
754476005209	MutS domain III; Region: MutS_III; pfam05192
754476005210	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
754476005211	Walker A/P-loop; other site
754476005212	ATP binding site [chemical binding]; other site
754476005213	Q-loop/lid; other site
754476005214	ABC transporter signature motif; other site
754476005215	Walker B; other site
754476005216	D-loop; other site
754476005217	H-loop/switch region; other site
754476005218	YcgL domain; Region: YcgL; pfam05166
754476005219	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
754476005220	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
754476005221	active site
754476005222	metal binding site [ion binding]; metal-binding site
754476005223	OsmC-like protein; Region: OsmC; cl00767
754476005224	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
754476005225	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
754476005226	ligand binding site [chemical binding]; other site
754476005227	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
754476005228	putative switch regulator; other site
754476005229	non-specific DNA interactions [nucleotide binding]; other site
754476005230	DNA binding site [nucleotide binding]
754476005231	sequence specific DNA binding site [nucleotide binding]; other site
754476005232	putative cAMP binding site [chemical binding]; other site
754476005233	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
754476005234	active site
754476005235	ribulose/triose binding site [chemical binding]; other site
754476005236	phosphate binding site [ion binding]; other site
754476005237	substrate (anthranilate) binding pocket [chemical binding]; other site
754476005238	product (indole) binding pocket [chemical binding]; other site
754476005239	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
754476005240	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
754476005241	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
754476005242	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
754476005243	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
754476005244	glutamine binding [chemical binding]; other site
754476005245	catalytic triad [active]
754476005246	anthranilate synthase component I; Provisional; Region: PRK13565
754476005247	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
754476005248	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
754476005249	phosphoglycolate phosphatase; Provisional; Region: PRK13222
754476005250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476005251	motif II; other site
754476005252	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
754476005253	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
754476005254	substrate binding site [chemical binding]; other site
754476005255	hexamer interface [polypeptide binding]; other site
754476005256	metal binding site [ion binding]; metal-binding site
754476005257	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
754476005258	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
754476005259	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
754476005260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
754476005261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
754476005262	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
754476005263	hypothetical protein; Provisional; Region: PRK01254
754476005264	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
754476005265	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
754476005266	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
754476005267	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
754476005268	hypothetical protein; Provisional; Region: PRK03757
754476005269	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
754476005270	Glycoprotease family; Region: Peptidase_M22; pfam00814
754476005271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005272	S-adenosylmethionine binding site [chemical binding]; other site
754476005273	Methyltransferase domain; Region: Methyltransf_31; pfam13847
754476005274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005275	S-adenosylmethionine binding site [chemical binding]; other site
754476005276	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
754476005277	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476005278	Coenzyme A binding pocket [chemical binding]; other site
754476005279	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
754476005280	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
754476005281	transmembrane helices; other site
754476005282	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
754476005283	TrkA-C domain; Region: TrkA_C; pfam02080
754476005284	TrkA-C domain; Region: TrkA_C; pfam02080
754476005285	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
754476005286	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
754476005287	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
754476005288	Ion transport protein; Region: Ion_trans; pfam00520
754476005289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476005290	PAS domain; Region: PAS_9; pfam13426
754476005291	putative active site [active]
754476005292	heme pocket [chemical binding]; other site
754476005293	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005294	metal binding site [ion binding]; metal-binding site
754476005295	active site
754476005296	I-site; other site
754476005297	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476005298	MerC mercury resistance protein; Region: MerC; pfam03203
754476005299	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
754476005300	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
754476005301	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
754476005302	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
754476005303	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
754476005304	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
754476005305	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
754476005306	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
754476005307	metal binding site 2 [ion binding]; metal-binding site
754476005308	putative DNA binding helix; other site
754476005309	metal binding site 1 [ion binding]; metal-binding site
754476005310	dimer interface [polypeptide binding]; other site
754476005311	structural Zn2+ binding site [ion binding]; other site
754476005312	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
754476005313	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476005314	Walker A/P-loop; other site
754476005315	ATP binding site [chemical binding]; other site
754476005316	Q-loop/lid; other site
754476005317	ABC transporter signature motif; other site
754476005318	Walker B; other site
754476005319	D-loop; other site
754476005320	H-loop/switch region; other site
754476005321	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476005322	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
754476005323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476005324	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476005325	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476005326	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
754476005327	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
754476005328	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
754476005329	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
754476005330	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
754476005331	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
754476005332	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
754476005333	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
754476005334	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
754476005335	active site
754476005336	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
754476005337	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
754476005338	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
754476005339	Walker A/P-loop; other site
754476005340	ATP binding site [chemical binding]; other site
754476005341	Q-loop/lid; other site
754476005342	ABC transporter signature motif; other site
754476005343	Walker B; other site
754476005344	D-loop; other site
754476005345	H-loop/switch region; other site
754476005346	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
754476005347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005349	metal binding site [ion binding]; metal-binding site
754476005350	active site
754476005351	I-site; other site
754476005352	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
754476005353	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
754476005354	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
754476005355	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
754476005356	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476005357	N-terminal plug; other site
754476005358	ligand-binding site [chemical binding]; other site
754476005359	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
754476005360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476005361	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476005362	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476005363	short chain dehydrogenase; Validated; Region: PRK08264
754476005364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476005365	NAD(P) binding site [chemical binding]; other site
754476005366	active site
754476005367	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
754476005368	DNA-binding site [nucleotide binding]; DNA binding site
754476005369	RNA-binding motif; other site
754476005370	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
754476005371	GAF domain; Region: GAF; pfam01590
754476005372	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005373	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005374	metal binding site [ion binding]; metal-binding site
754476005375	active site
754476005376	I-site; other site
754476005377	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
754476005378	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
754476005379	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476005380	dimerization interface [polypeptide binding]; other site
754476005381	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476005382	dimer interface [polypeptide binding]; other site
754476005383	putative CheW interface [polypeptide binding]; other site
754476005384	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476005385	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476005386	Helix-turn-helix domain; Region: HTH_28; pfam13518
754476005387	Winged helix-turn helix; Region: HTH_29; pfam13551
754476005388	Predicted flavoprotein [General function prediction only]; Region: COG0431
754476005389	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
754476005390	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
754476005391	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
754476005392	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476005393	N-terminal plug; other site
754476005394	ligand-binding site [chemical binding]; other site
754476005395	malate dehydrogenase; Provisional; Region: PRK13529
754476005396	Malic enzyme, N-terminal domain; Region: malic; pfam00390
754476005397	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
754476005398	NAD(P) binding site [chemical binding]; other site
754476005399	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
754476005400	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
754476005401	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476005402	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476005403	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476005404	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
754476005405	Walker A/P-loop; other site
754476005406	ATP binding site [chemical binding]; other site
754476005407	Q-loop/lid; other site
754476005408	ABC transporter signature motif; other site
754476005409	Walker B; other site
754476005410	D-loop; other site
754476005411	H-loop/switch region; other site
754476005412	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476005413	Walker A/P-loop; other site
754476005414	ATP binding site [chemical binding]; other site
754476005415	Q-loop/lid; other site
754476005416	ABC transporter signature motif; other site
754476005417	Walker B; other site
754476005418	D-loop; other site
754476005419	H-loop/switch region; other site
754476005420	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476005421	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
754476005422	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476005423	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
754476005424	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
754476005425	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
754476005426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476005427	motif II; other site
754476005428	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
754476005429	active site
754476005430	catalytic triad [active]
754476005431	oxyanion hole [active]
754476005432	switch loop; other site
754476005433	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
754476005434	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
754476005435	Walker A/P-loop; other site
754476005436	ATP binding site [chemical binding]; other site
754476005437	Q-loop/lid; other site
754476005438	ABC transporter signature motif; other site
754476005439	Walker B; other site
754476005440	D-loop; other site
754476005441	H-loop/switch region; other site
754476005442	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
754476005443	FtsX-like permease family; Region: FtsX; pfam02687
754476005444	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
754476005445	Transglycosylase; Region: Transgly; cl17702
754476005446	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
754476005447	fumarate hydratase; Reviewed; Region: fumC; PRK00485
754476005448	Class II fumarases; Region: Fumarase_classII; cd01362
754476005449	active site
754476005450	tetramer interface [polypeptide binding]; other site
754476005451	Uncharacterized conserved protein [Function unknown]; Region: COG3339
754476005452	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476005453	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
754476005454	putative active site [active]
754476005455	heme pocket [chemical binding]; other site
754476005456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476005457	putative active site [active]
754476005458	heme pocket [chemical binding]; other site
754476005459	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476005460	dimer interface [polypeptide binding]; other site
754476005461	putative CheW interface [polypeptide binding]; other site
754476005462	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
754476005463	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476005464	substrate binding pocket [chemical binding]; other site
754476005465	membrane-bound complex binding site; other site
754476005466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
754476005467	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476005468	dimerization interface [polypeptide binding]; other site
754476005469	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476005470	putative active site [active]
754476005471	heme pocket [chemical binding]; other site
754476005472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476005473	dimer interface [polypeptide binding]; other site
754476005474	phosphorylation site [posttranslational modification]
754476005475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005476	ATP binding site [chemical binding]; other site
754476005477	G-X-G motif; other site
754476005478	Response regulator receiver domain; Region: Response_reg; pfam00072
754476005479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005480	active site
754476005481	phosphorylation site [posttranslational modification]
754476005482	intermolecular recognition site; other site
754476005483	dimerization interface [polypeptide binding]; other site
754476005484	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
754476005485	Predicted metalloprotease [General function prediction only]; Region: COG2321
754476005486	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
754476005487	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
754476005488	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
754476005489	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
754476005490	Predicted membrane protein [Function unknown]; Region: COG3671
754476005491	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476005492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005493	active site
754476005494	phosphorylation site [posttranslational modification]
754476005495	intermolecular recognition site; other site
754476005496	dimerization interface [polypeptide binding]; other site
754476005497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476005498	DNA binding site [nucleotide binding]
754476005499	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476005500	dimer interface [polypeptide binding]; other site
754476005501	phosphorylation site [posttranslational modification]
754476005502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005503	ATP binding site [chemical binding]; other site
754476005504	Mg2+ binding site [ion binding]; other site
754476005505	G-X-G motif; other site
754476005506	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
754476005507	TrkA-N domain; Region: TrkA_N; pfam02254
754476005508	TrkA-C domain; Region: TrkA_C; pfam02080
754476005509	TrkA-N domain; Region: TrkA_N; pfam02254
754476005510	TrkA-C domain; Region: TrkA_C; pfam02080
754476005511	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
754476005512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476005513	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
754476005514	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
754476005515	heat shock protein 70; Region: dnaK; CHL00094
754476005516	PEGA domain; Region: PEGA; pfam08308
754476005517	PEGA domain; Region: PEGA; pfam08308
754476005518	PEGA domain; Region: PEGA; pfam08308
754476005519	Uncharacterized conserved protein [Function unknown]; Region: COG1262
754476005520	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
754476005521	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476005522	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
754476005523	metal ion-dependent adhesion site (MIDAS); other site
754476005524	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
754476005525	CHASE2 domain; Region: CHASE2; cl01732
754476005526	CHASE2 domain; Region: CHASE2; cl01732
754476005527	Peptidase family M48; Region: Peptidase_M48; cl12018
754476005528	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
754476005529	Nuclease-related domain; Region: NERD; pfam08378
754476005530	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
754476005531	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
754476005532	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
754476005533	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476005534	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476005535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005536	active site
754476005537	phosphorylation site [posttranslational modification]
754476005538	intermolecular recognition site; other site
754476005539	dimerization interface [polypeptide binding]; other site
754476005540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
754476005541	DNA binding residues [nucleotide binding]
754476005542	dimerization interface [polypeptide binding]; other site
754476005543	Histidine kinase; Region: HisKA_3; pfam07730
754476005544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005545	ATP binding site [chemical binding]; other site
754476005546	Mg2+ binding site [ion binding]; other site
754476005547	G-X-G motif; other site
754476005548	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
754476005549	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
754476005550	inhibitor site; inhibition site
754476005551	active site
754476005552	dimer interface [polypeptide binding]; other site
754476005553	catalytic residue [active]
754476005554	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
754476005555	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476005556	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
754476005557	dimerization interface [polypeptide binding]; other site
754476005558	NnrS protein; Region: NnrS; pfam05940
754476005559	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
754476005560	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
754476005561	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476005562	putative DNA binding site [nucleotide binding]; other site
754476005563	putative Zn2+ binding site [ion binding]; other site
754476005564	Transcriptional regulator PadR-like family; Region: PadR; cl17335
754476005565	TniQ; Region: TniQ; pfam06527
754476005566	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
754476005567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476005568	Walker A motif; other site
754476005569	ATP binding site [chemical binding]; other site
754476005570	Walker B motif; other site
754476005571	arginine finger; other site
754476005572	Integrase core domain; Region: rve; pfam00665
754476005573	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
754476005574	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
754476005575	sensor kinase CusS; Provisional; Region: PRK09835
754476005576	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476005577	dimerization interface [polypeptide binding]; other site
754476005578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476005579	dimer interface [polypeptide binding]; other site
754476005580	phosphorylation site [posttranslational modification]
754476005581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005582	ATP binding site [chemical binding]; other site
754476005583	Mg2+ binding site [ion binding]; other site
754476005584	G-X-G motif; other site
754476005585	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
754476005586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005587	active site
754476005588	phosphorylation site [posttranslational modification]
754476005589	intermolecular recognition site; other site
754476005590	dimerization interface [polypeptide binding]; other site
754476005591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476005592	DNA binding site [nucleotide binding]
754476005593	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
754476005594	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
754476005595	Multicopper oxidase; Region: Cu-oxidase; pfam00394
754476005596	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
754476005597	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
754476005598	amino acid transporter; Region: 2A0306; TIGR00909
754476005599	EamA-like transporter family; Region: EamA; pfam00892
754476005600	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
754476005601	EamA-like transporter family; Region: EamA; pfam00892
754476005602	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
754476005603	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
754476005604	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
754476005605	metal-binding site [ion binding]
754476005606	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
754476005607	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
754476005608	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
754476005609	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
754476005610	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
754476005611	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
754476005612	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
754476005613	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
754476005614	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
754476005615	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
754476005616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476005617	ATP binding site [chemical binding]; other site
754476005618	Walker B motif; other site
754476005619	arginine finger; other site
754476005620	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
754476005621	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
754476005622	putative active site [active]
754476005623	putative metal binding site [ion binding]; other site
754476005624	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
754476005625	ATP binding site [chemical binding]; other site
754476005626	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
754476005627	active site
754476005628	NTP binding site [chemical binding]; other site
754476005629	metal binding triad [ion binding]; metal-binding site
754476005630	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
754476005631	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
754476005632	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
754476005633	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476005634	ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252
754476005635	Walker A/P-loop; other site
754476005636	ATP binding site [chemical binding]; other site
754476005637	Q-loop/lid; other site
754476005638	ABC transporter signature motif; other site
754476005639	Walker B; other site
754476005640	D-loop; other site
754476005641	H-loop/switch region; other site
754476005642	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
754476005643	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476005644	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476005645	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
754476005646	nucleophilic elbow; other site
754476005647	catalytic triad; other site
754476005648	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
754476005649	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
754476005650	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
754476005651	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
754476005652	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
754476005653	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
754476005654	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
754476005655	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
754476005656	Cadherin repeat-like domain; Region: CA_like; cl15786
754476005657	Ca2+ binding site [ion binding]; other site
754476005658	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
754476005659	Cadherin repeat-like domain; Region: CA_like; cl15786
754476005660	Ca2+ binding site [ion binding]; other site
754476005661	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
754476005662	Cadherin repeat-like domain; Region: CA_like; cl15786
754476005663	Ca2+ binding site [ion binding]; other site
754476005664	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
754476005665	Cadherin repeat-like domain; Region: CA_like; cl15786
754476005666	Ca2+ binding site [ion binding]; other site
754476005667	AAA domain; Region: AAA_21; pfam13304
754476005668	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
754476005669	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
754476005670	TPR repeat; Region: TPR_11; pfam13414
754476005671	binding surface
754476005672	TPR motif; other site
754476005673	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
754476005674	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
754476005675	AAA domain; Region: AAA_22; pfam13401
754476005676	Bacterial TniB protein; Region: TniB; pfam05621
754476005677	Integrase core domain; Region: rve; pfam00665
754476005678	Integrase core domain; Region: rve_3; cl15866
754476005679	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
754476005680	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
754476005681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476005682	sequence-specific DNA binding site [nucleotide binding]; other site
754476005683	salt bridge; other site
754476005684	DNA methylase; Region: N6_N4_Mtase; cl17433
754476005685	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476005686	AAA domain; Region: AAA_23; pfam13476
754476005687	Walker A/P-loop; other site
754476005688	ATP binding site [chemical binding]; other site
754476005689	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
754476005690	Integrase core domain; Region: rve; pfam00665
754476005691	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
754476005692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476005693	Walker A motif; other site
754476005694	ATP binding site [chemical binding]; other site
754476005695	Walker B motif; other site
754476005696	arginine finger; other site
754476005697	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
754476005698	dimer interface [polypeptide binding]; other site
754476005699	putative radical transfer pathway; other site
754476005700	diiron center [ion binding]; other site
754476005701	tyrosyl radical; other site
754476005702	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
754476005703	ATP cone domain; Region: ATP-cone; pfam03477
754476005704	ATP cone domain; Region: ATP-cone; pfam03477
754476005705	Class I ribonucleotide reductase; Region: RNR_I; cd01679
754476005706	active site
754476005707	dimer interface [polypeptide binding]; other site
754476005708	catalytic residues [active]
754476005709	effector binding site; other site
754476005710	R2 peptide binding site; other site
754476005711	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
754476005712	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
754476005713	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
754476005714	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
754476005715	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476005716	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476005717	Walker A/P-loop; other site
754476005718	ATP binding site [chemical binding]; other site
754476005719	Q-loop/lid; other site
754476005720	ABC transporter signature motif; other site
754476005721	Walker B; other site
754476005722	D-loop; other site
754476005723	H-loop/switch region; other site
754476005724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476005725	Walker A/P-loop; other site
754476005726	ATP binding site [chemical binding]; other site
754476005727	ABC transporter; Region: ABC_tran; pfam00005
754476005728	Q-loop/lid; other site
754476005729	ABC transporter signature motif; other site
754476005730	Walker B; other site
754476005731	D-loop; other site
754476005732	H-loop/switch region; other site
754476005733	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
754476005734	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
754476005735	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
754476005736	haemagglutination activity domain; Region: Haemagg_act; pfam05860
754476005737	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
754476005738	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
754476005739	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
754476005740	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476005741	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476005742	Tetratricopeptide repeat; Region: TPR_12; pfam13424
754476005743	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
754476005744	putative active site [active]
754476005745	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
754476005746	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
754476005747	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
754476005748	DNA binding residues [nucleotide binding]
754476005749	putative dimer interface [polypeptide binding]; other site
754476005750	putative metal binding residues [ion binding]; other site
754476005751	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
754476005752	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
754476005753	Uncharacterized conserved protein [Function unknown]; Region: COG0397
754476005754	hypothetical protein; Validated; Region: PRK00029
754476005755	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
754476005756	YccA-like proteins; Region: YccA_like; cd10433
754476005757	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
754476005758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476005759	FeS/SAM binding site; other site
754476005760	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
754476005761	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
754476005762	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
754476005763	homodimer interface [polypeptide binding]; other site
754476005764	active site
754476005765	putative chemical substrate binding site [chemical binding]; other site
754476005766	metal binding site [ion binding]; metal-binding site
754476005767	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476005768	RNA binding surface [nucleotide binding]; other site
754476005769	acetyl-CoA synthetase; Provisional; Region: PRK00174
754476005770	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
754476005771	active site
754476005772	CoA binding site [chemical binding]; other site
754476005773	acyl-activating enzyme (AAE) consensus motif; other site
754476005774	AMP binding site [chemical binding]; other site
754476005775	acetate binding site [chemical binding]; other site
754476005776	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
754476005777	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
754476005778	NAD(P) binding site [chemical binding]; other site
754476005779	catalytic residues [active]
754476005780	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
754476005781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476005782	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
754476005783	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
754476005784	Surface antigen; Region: Bac_surface_Ag; pfam01103
754476005785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
754476005786	Family of unknown function (DUF490); Region: DUF490; pfam04357
754476005787	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
754476005788	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
754476005789	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476005790	motif II; other site
754476005791	hypothetical protein; Provisional; Region: PRK08960
754476005792	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476005793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476005794	homodimer interface [polypeptide binding]; other site
754476005795	catalytic residue [active]
754476005796	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
754476005797	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
754476005798	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476005799	N-terminal plug; other site
754476005800	ligand-binding site [chemical binding]; other site
754476005801	putative sulfate transport protein CysZ; Validated; Region: PRK04949
754476005802	D-xylulose kinase; Region: XylB; TIGR01312
754476005803	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
754476005804	nucleotide binding site [chemical binding]; other site
754476005805	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
754476005806	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
754476005807	FtsZ protein binding site [polypeptide binding]; other site
754476005808	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
754476005809	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
754476005810	nucleotide binding pocket [chemical binding]; other site
754476005811	K-X-D-G motif; other site
754476005812	catalytic site [active]
754476005813	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
754476005814	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
754476005815	Dimer interface [polypeptide binding]; other site
754476005816	BRCT sequence motif; other site
754476005817	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
754476005818	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
754476005819	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
754476005820	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
754476005821	Protein of unknown function (DUF615); Region: DUF615; cl01147
754476005822	HAMP domain; Region: HAMP; pfam00672
754476005823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005824	ATP binding site [chemical binding]; other site
754476005825	Mg2+ binding site [ion binding]; other site
754476005826	G-X-G motif; other site
754476005827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476005828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005829	active site
754476005830	phosphorylation site [posttranslational modification]
754476005831	intermolecular recognition site; other site
754476005832	dimerization interface [polypeptide binding]; other site
754476005833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476005834	DNA binding site [nucleotide binding]
754476005835	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
754476005836	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
754476005837	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
754476005838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476005839	ATP binding site [chemical binding]; other site
754476005840	putative Mg++ binding site [ion binding]; other site
754476005841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476005842	nucleotide binding region [chemical binding]; other site
754476005843	ATP-binding site [chemical binding]; other site
754476005844	Helicase associated domain (HA2); Region: HA2; pfam04408
754476005845	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
754476005846	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
754476005847	Protein of unknown function, DUF481; Region: DUF481; pfam04338
754476005848	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
754476005849	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476005850	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
754476005851	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476005852	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
754476005853	putative FMN binding site [chemical binding]; other site
754476005854	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
754476005855	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
754476005856	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
754476005857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
754476005858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005859	S-adenosylmethionine binding site [chemical binding]; other site
754476005860	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
754476005861	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476005862	P-loop; other site
754476005863	Magnesium ion binding site [ion binding]; other site
754476005864	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476005865	Magnesium ion binding site [ion binding]; other site
754476005866	polyphosphate kinase; Provisional; Region: PRK05443
754476005867	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
754476005868	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
754476005869	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
754476005870	putative domain interface [polypeptide binding]; other site
754476005871	putative active site [active]
754476005872	catalytic site [active]
754476005873	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
754476005874	putative domain interface [polypeptide binding]; other site
754476005875	putative active site [active]
754476005876	catalytic site [active]
754476005877	hypothetical protein; Provisional; Region: PRK05170
754476005878	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
754476005879	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
754476005880	active site
754476005881	metal binding site [ion binding]; metal-binding site
754476005882	Protein of unknown function (DUF445); Region: DUF445; pfam04286
754476005883	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476005884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005885	Uncharacterized conserved protein [Function unknown]; Region: COG1739
754476005886	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
754476005887	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
754476005888	ATP-dependent helicase HepA; Validated; Region: PRK04914
754476005889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476005890	ATP binding site [chemical binding]; other site
754476005891	putative Mg++ binding site [ion binding]; other site
754476005892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476005893	nucleotide binding region [chemical binding]; other site
754476005894	ATP-binding site [chemical binding]; other site
754476005895	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
754476005896	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476005897	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476005898	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
754476005899	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
754476005900	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
754476005901	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476005902	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476005903	metal binding site [ion binding]; metal-binding site
754476005904	active site
754476005905	I-site; other site
754476005906	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476005907	Predicted permeases [General function prediction only]; Region: COG0679
754476005908	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
754476005909	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
754476005910	putative MPT binding site; other site
754476005911	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
754476005912	apolar tunnel; other site
754476005913	heme binding site [chemical binding]; other site
754476005914	dimerization interface [polypeptide binding]; other site
754476005915	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
754476005916	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
754476005917	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
754476005918	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
754476005919	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
754476005920	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
754476005921	aromatic arch; other site
754476005922	DCoH dimer interaction site [polypeptide binding]; other site
754476005923	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
754476005924	DCoH tetramer interaction site [polypeptide binding]; other site
754476005925	substrate binding site [chemical binding]; other site
754476005926	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
754476005927	active site
754476005928	catalytic residues [active]
754476005929	DNA binding site [nucleotide binding]
754476005930	Int/Topo IB signature motif; other site
754476005931	AAA domain; Region: AAA_22; pfam13401
754476005932	Integrase core domain; Region: rve; pfam00665
754476005933	Integrase core domain; Region: rve_3; cl15866
754476005934	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
754476005935	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
754476005936	Methyltransferase domain; Region: Methyltransf_31; pfam13847
754476005937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005938	S-adenosylmethionine binding site [chemical binding]; other site
754476005939	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
754476005940	Sulfatase; Region: Sulfatase; pfam00884
754476005941	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
754476005942	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
754476005943	active site
754476005944	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476005945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476005946	active site
754476005947	phosphorylation site [posttranslational modification]
754476005948	intermolecular recognition site; other site
754476005949	dimerization interface [polypeptide binding]; other site
754476005950	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476005951	DNA binding site [nucleotide binding]
754476005952	sensor protein QseC; Provisional; Region: PRK10337
754476005953	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476005954	dimer interface [polypeptide binding]; other site
754476005955	phosphorylation site [posttranslational modification]
754476005956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476005957	ATP binding site [chemical binding]; other site
754476005958	Mg2+ binding site [ion binding]; other site
754476005959	G-X-G motif; other site
754476005960	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
754476005961	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
754476005962	Sulfatase; Region: Sulfatase; pfam00884
754476005963	Integrase core domain; Region: rve_3; cl15866
754476005964	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
754476005965	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
754476005966	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
754476005967	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
754476005968	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476005969	ATP binding site [chemical binding]; other site
754476005970	putative Mg++ binding site [ion binding]; other site
754476005971	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
754476005972	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
754476005973	HsdM N-terminal domain; Region: HsdM_N; pfam12161
754476005974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476005975	S-adenosylmethionine binding site [chemical binding]; other site
754476005976	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
754476005977	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
754476005978	putative [4Fe-4S] binding site [ion binding]; other site
754476005979	putative molybdopterin cofactor binding site [chemical binding]; other site
754476005980	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
754476005981	putative molybdopterin cofactor binding site; other site
754476005982	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
754476005983	4Fe-4S binding domain; Region: Fer4; pfam00037
754476005984	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
754476005985	ferredoxin-NADP+ reductase; Region: PLN02852
754476005986	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
754476005987	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476005988	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
754476005989	Trp docking motif [polypeptide binding]; other site
754476005990	dimer interface [polypeptide binding]; other site
754476005991	active site
754476005992	small subunit binding site [polypeptide binding]; other site
754476005993	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
754476005994	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
754476005995	heme-binding site [chemical binding]; other site
754476005996	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
754476005997	FAD binding pocket [chemical binding]; other site
754476005998	FAD binding motif [chemical binding]; other site
754476005999	phosphate binding motif [ion binding]; other site
754476006000	beta-alpha-beta structure motif; other site
754476006001	NAD binding pocket [chemical binding]; other site
754476006002	Heme binding  pocket [chemical binding]; other site
754476006003	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
754476006004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476006005	dimer interface [polypeptide binding]; other site
754476006006	phosphorylation site [posttranslational modification]
754476006007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476006008	ATP binding site [chemical binding]; other site
754476006009	Mg2+ binding site [ion binding]; other site
754476006010	G-X-G motif; other site
754476006011	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476006012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476006013	active site
754476006014	phosphorylation site [posttranslational modification]
754476006015	intermolecular recognition site; other site
754476006016	dimerization interface [polypeptide binding]; other site
754476006017	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476006018	DNA binding site [nucleotide binding]
754476006019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476006020	TPR motif; other site
754476006021	binding surface
754476006022	short chain dehydrogenase; Provisional; Region: PRK09072
754476006023	classical (c) SDRs; Region: SDR_c; cd05233
754476006024	NAD(P) binding site [chemical binding]; other site
754476006025	active site
754476006026	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
754476006027	heme binding pocket [chemical binding]; other site
754476006028	heme ligand [chemical binding]; other site
754476006029	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
754476006030	AMP-binding enzyme; Region: AMP-binding; pfam00501
754476006031	acyl-activating enzyme (AAE) consensus motif; other site
754476006032	AMP binding site [chemical binding]; other site
754476006033	active site
754476006034	CoA binding site [chemical binding]; other site
754476006035	Thermostable hemolysin; Region: T_hemolysin; pfam12261
754476006036	putative transporter; Provisional; Region: PRK11660
754476006037	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
754476006038	Sulfate transporter family; Region: Sulfate_transp; pfam00916
754476006039	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
754476006040	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
754476006041	Sulfatase; Region: Sulfatase; pfam00884
754476006042	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
754476006043	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
754476006044	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
754476006045	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
754476006046	putative dimer interface [polypeptide binding]; other site
754476006047	N-terminal domain interface [polypeptide binding]; other site
754476006048	putative substrate binding pocket (H-site) [chemical binding]; other site
754476006049	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
754476006050	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
754476006051	Protein export membrane protein; Region: SecD_SecF; pfam02355
754476006052	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
754476006053	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476006054	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
754476006055	Peptidase family M48; Region: Peptidase_M48; cl12018
754476006056	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
754476006057	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
754476006058	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476006059	Walker A/P-loop; other site
754476006060	ATP binding site [chemical binding]; other site
754476006061	Q-loop/lid; other site
754476006062	ABC transporter signature motif; other site
754476006063	Walker B; other site
754476006064	D-loop; other site
754476006065	H-loop/switch region; other site
754476006066	ABC transporter; Region: ABC_tran_2; pfam12848
754476006067	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
754476006068	Transposase; Region: DEDD_Tnp_IS110; pfam01548
754476006069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
754476006070	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
754476006071	sulfite reductase subunit beta; Provisional; Region: PRK13504
754476006072	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
754476006073	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
754476006074	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
754476006075	Flavodoxin; Region: Flavodoxin_1; pfam00258
754476006076	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
754476006077	FAD binding pocket [chemical binding]; other site
754476006078	FAD binding motif [chemical binding]; other site
754476006079	catalytic residues [active]
754476006080	NAD binding pocket [chemical binding]; other site
754476006081	phosphate binding motif [ion binding]; other site
754476006082	beta-alpha-beta structure motif; other site
754476006083	Response regulator receiver domain; Region: Response_reg; pfam00072
754476006084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476006085	active site
754476006086	phosphorylation site [posttranslational modification]
754476006087	intermolecular recognition site; other site
754476006088	dimerization interface [polypeptide binding]; other site
754476006089	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476006090	GAF domain; Region: GAF; pfam01590
754476006091	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476006092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476006093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006094	metal binding site [ion binding]; metal-binding site
754476006095	active site
754476006096	I-site; other site
754476006097	PAS fold; Region: PAS_3; pfam08447
754476006098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006099	PAS fold; Region: PAS_3; pfam08447
754476006100	putative active site [active]
754476006101	heme pocket [chemical binding]; other site
754476006102	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476006103	GAF domain; Region: GAF; pfam01590
754476006104	PAS domain S-box; Region: sensory_box; TIGR00229
754476006105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006106	putative active site [active]
754476006107	heme pocket [chemical binding]; other site
754476006108	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
754476006109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006110	putative active site [active]
754476006111	heme pocket [chemical binding]; other site
754476006112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006113	putative active site [active]
754476006114	heme pocket [chemical binding]; other site
754476006115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476006116	dimer interface [polypeptide binding]; other site
754476006117	phosphorylation site [posttranslational modification]
754476006118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476006119	ATP binding site [chemical binding]; other site
754476006120	Mg2+ binding site [ion binding]; other site
754476006121	G-X-G motif; other site
754476006122	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476006123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476006124	active site
754476006125	phosphorylation site [posttranslational modification]
754476006126	intermolecular recognition site; other site
754476006127	dimerization interface [polypeptide binding]; other site
754476006128	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476006129	dimerization interface [polypeptide binding]; other site
754476006130	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476006131	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476006132	dimer interface [polypeptide binding]; other site
754476006133	putative CheW interface [polypeptide binding]; other site
754476006134	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
754476006135	active site
754476006136	catalytic triad [active]
754476006137	oxyanion hole [active]
754476006138	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
754476006139	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
754476006140	active site
754476006141	PilZ domain; Region: PilZ; cl01260
754476006142	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
754476006143	DNA polymerase III subunit delta'; Validated; Region: PRK08485
754476006144	thymidylate kinase; Validated; Region: tmk; PRK00698
754476006145	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
754476006146	TMP-binding site; other site
754476006147	ATP-binding site [chemical binding]; other site
754476006148	YceG-like family; Region: YceG; pfam02618
754476006149	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
754476006150	dimerization interface [polypeptide binding]; other site
754476006151	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
754476006152	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
754476006153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006154	catalytic residue [active]
754476006155	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
754476006156	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
754476006157	dimer interface [polypeptide binding]; other site
754476006158	active site
754476006159	acyl carrier protein; Provisional; Region: acpP; PRK00982
754476006160	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
754476006161	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
754476006162	NAD(P) binding site [chemical binding]; other site
754476006163	homotetramer interface [polypeptide binding]; other site
754476006164	homodimer interface [polypeptide binding]; other site
754476006165	active site
754476006166	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
754476006167	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
754476006168	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
754476006169	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
754476006170	dimer interface [polypeptide binding]; other site
754476006171	active site
754476006172	CoA binding pocket [chemical binding]; other site
754476006173	putative phosphate acyltransferase; Provisional; Region: PRK05331
754476006174	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
754476006175	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
754476006176	amidophosphoribosyltransferase; Provisional; Region: PRK09246
754476006177	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
754476006178	active site
754476006179	tetramer interface [polypeptide binding]; other site
754476006180	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476006181	active site
754476006182	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
754476006183	Colicin V production protein; Region: Colicin_V; cl00567
754476006184	Sporulation related domain; Region: SPOR; pfam05036
754476006185	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
754476006186	Found in ATP-dependent protease La (LON); Region: LON; smart00464
754476006187	Found in ATP-dependent protease La (LON); Region: LON; smart00464
754476006188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476006189	Walker A motif; other site
754476006190	ATP binding site [chemical binding]; other site
754476006191	Walker B motif; other site
754476006192	arginine finger; other site
754476006193	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
754476006194	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
754476006195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476006196	Walker A motif; other site
754476006197	ATP binding site [chemical binding]; other site
754476006198	Walker B motif; other site
754476006199	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
754476006200	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
754476006201	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
754476006202	oligomer interface [polypeptide binding]; other site
754476006203	active site residues [active]
754476006204	trigger factor; Provisional; Region: tig; PRK01490
754476006205	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
754476006206	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
754476006207	HDOD domain; Region: HDOD; pfam08668
754476006208	GAF domain; Region: GAF; pfam01590
754476006209	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
754476006210	Cation efflux family; Region: Cation_efflux; cl00316
754476006211	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
754476006212	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
754476006213	phosphoglucomutase; Region: PLN02307
754476006214	substrate binding site [chemical binding]; other site
754476006215	dimer interface [polypeptide binding]; other site
754476006216	active site
754476006217	metal binding site [ion binding]; metal-binding site
754476006218	Maf-like protein; Region: Maf; pfam02545
754476006219	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
754476006220	active site
754476006221	dimer interface [polypeptide binding]; other site
754476006222	Phosphotransferase enzyme family; Region: APH; pfam01636
754476006223	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
754476006224	substrate binding site [chemical binding]; other site
754476006225	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
754476006226	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
754476006227	Substrate binding site; other site
754476006228	metal-binding site
754476006229	ornithine carbamoyltransferase; Provisional; Region: PRK00779
754476006230	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
754476006231	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
754476006232	acetylornithine aminotransferase; Provisional; Region: PRK02627
754476006233	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
754476006234	inhibitor-cofactor binding pocket; inhibition site
754476006235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006236	catalytic residue [active]
754476006237	superoxide dismutase; Provisional; Region: PRK10543
754476006238	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
754476006239	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
754476006240	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
754476006241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476006242	Coenzyme A binding pocket [chemical binding]; other site
754476006243	2-isopropylmalate synthase; Validated; Region: PRK00915
754476006244	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
754476006245	active site
754476006246	catalytic residues [active]
754476006247	metal binding site [ion binding]; metal-binding site
754476006248	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
754476006249	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
754476006250	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
754476006251	ketol-acid reductoisomerase; Provisional; Region: PRK05479
754476006252	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
754476006253	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
754476006254	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
754476006255	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
754476006256	putative valine binding site [chemical binding]; other site
754476006257	dimer interface [polypeptide binding]; other site
754476006258	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
754476006259	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
754476006260	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
754476006261	PYR/PP interface [polypeptide binding]; other site
754476006262	dimer interface [polypeptide binding]; other site
754476006263	TPP binding site [chemical binding]; other site
754476006264	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
754476006265	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
754476006266	TPP-binding site [chemical binding]; other site
754476006267	dimer interface [polypeptide binding]; other site
754476006268	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
754476006269	active site
754476006270	dimer interface [polypeptide binding]; other site
754476006271	substrate binding pocket [chemical binding]; other site
754476006272	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
754476006273	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
754476006274	potential catalytic triad [active]
754476006275	conserved cys residue [active]
754476006276	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
754476006277	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
754476006278	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
754476006279	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
754476006280	DEAD_2; Region: DEAD_2; pfam06733
754476006281	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
754476006282	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
754476006283	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
754476006284	putative ligand binding site [chemical binding]; other site
754476006285	putative NAD binding site [chemical binding]; other site
754476006286	catalytic site [active]
754476006287	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
754476006288	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
754476006289	putative substrate binding site [chemical binding]; other site
754476006290	putative ATP binding site [chemical binding]; other site
754476006291	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
754476006292	DHH family; Region: DHH; pfam01368
754476006293	DHHA1 domain; Region: DHHA1; pfam02272
754476006294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
754476006295	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
754476006296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476006297	Walker A motif; other site
754476006298	ATP binding site [chemical binding]; other site
754476006299	Walker B motif; other site
754476006300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
754476006301	arginine finger; other site
754476006302	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
754476006303	Domain of unknown function DUF20; Region: UPF0118; pfam01594
754476006304	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
754476006305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3249
754476006306	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
754476006307	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
754476006308	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
754476006309	dimerization interface [polypeptide binding]; other site
754476006310	putative ATP binding site [chemical binding]; other site
754476006311	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
754476006312	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
754476006313	active site
754476006314	substrate binding site [chemical binding]; other site
754476006315	cosubstrate binding site; other site
754476006316	catalytic site [active]
754476006317	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
754476006318	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
754476006319	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
754476006320	dimer interface [polypeptide binding]; other site
754476006321	ADP-ribose binding site [chemical binding]; other site
754476006322	active site
754476006323	nudix motif; other site
754476006324	metal binding site [ion binding]; metal-binding site
754476006325	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
754476006326	active site
754476006327	phosphate binding residues; other site
754476006328	catalytic residues [active]
754476006329	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
754476006330	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
754476006331	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
754476006332	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
754476006333	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
754476006334	pseudouridine synthase; Region: TIGR00093
754476006335	active site
754476006336	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
754476006337	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
754476006338	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
754476006339	putative lysogenization regulator; Reviewed; Region: PRK00218
754476006340	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476006341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476006342	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
754476006343	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
754476006344	substrate binding site [chemical binding]; other site
754476006345	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
754476006346	substrate binding site [chemical binding]; other site
754476006347	ligand binding site [chemical binding]; other site
754476006348	adenylosuccinate lyase; Provisional; Region: PRK09285
754476006349	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
754476006350	tetramer interface [polypeptide binding]; other site
754476006351	active site
754476006352	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
754476006353	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
754476006354	dimer interface [polypeptide binding]; other site
754476006355	FMN binding site [chemical binding]; other site
754476006356	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476006357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006358	metal binding site [ion binding]; metal-binding site
754476006359	active site
754476006360	I-site; other site
754476006361	argininosuccinate synthase; Provisional; Region: PRK13820
754476006362	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
754476006363	ANP binding site [chemical binding]; other site
754476006364	Substrate Binding Site II [chemical binding]; other site
754476006365	Substrate Binding Site I [chemical binding]; other site
754476006366	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
754476006367	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
754476006368	E3 interaction surface; other site
754476006369	lipoyl attachment site [posttranslational modification]; other site
754476006370	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
754476006371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
754476006372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476006373	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
754476006374	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
754476006375	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
754476006376	E3 interaction surface; other site
754476006377	lipoyl attachment site [posttranslational modification]; other site
754476006378	e3 binding domain; Region: E3_binding; pfam02817
754476006379	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
754476006380	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
754476006381	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
754476006382	dimer interface [polypeptide binding]; other site
754476006383	TPP-binding site [chemical binding]; other site
754476006384	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
754476006385	TMAO/DMSO reductase; Reviewed; Region: PRK05363
754476006386	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
754476006387	Moco binding site; other site
754476006388	metal coordination site [ion binding]; other site
754476006389	DoxX; Region: DoxX; pfam07681
754476006390	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
754476006391	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
754476006392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476006393	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476006394	DNA binding residues [nucleotide binding]
754476006395	Putative zinc-finger; Region: zf-HC2; pfam13490
754476006396	Protein of unknown function (DUF1244); Region: DUF1244; cl01385
754476006397	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
754476006398	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
754476006399	Walker A/P-loop; other site
754476006400	ATP binding site [chemical binding]; other site
754476006401	Q-loop/lid; other site
754476006402	ABC transporter signature motif; other site
754476006403	Walker B; other site
754476006404	D-loop; other site
754476006405	H-loop/switch region; other site
754476006406	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
754476006407	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
754476006408	Walker A/P-loop; other site
754476006409	ATP binding site [chemical binding]; other site
754476006410	Q-loop/lid; other site
754476006411	ABC transporter signature motif; other site
754476006412	Walker B; other site
754476006413	D-loop; other site
754476006414	H-loop/switch region; other site
754476006415	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
754476006416	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
754476006417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476006418	dimer interface [polypeptide binding]; other site
754476006419	conserved gate region; other site
754476006420	putative PBP binding loops; other site
754476006421	ABC-ATPase subunit interface; other site
754476006422	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
754476006423	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
754476006424	Chorismate mutase type II; Region: CM_2; cl00693
754476006425	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
754476006426	Prephenate dehydratase; Region: PDT; pfam00800
754476006427	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
754476006428	putative L-Phe binding site [chemical binding]; other site
754476006429	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
754476006430	homodimer interface [polypeptide binding]; other site
754476006431	substrate-cofactor binding pocket; other site
754476006432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006433	catalytic residue [active]
754476006434	DNA gyrase subunit A; Validated; Region: PRK05560
754476006435	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
754476006436	CAP-like domain; other site
754476006437	active site
754476006438	primary dimer interface [polypeptide binding]; other site
754476006439	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
754476006440	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
754476006441	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
754476006442	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
754476006443	Protein of unknown function (DUF330); Region: DUF330; cl01135
754476006444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476006445	active site
754476006446	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
754476006447	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476006448	ligand binding site [chemical binding]; other site
754476006449	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
754476006450	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
754476006451	substrate binding site [chemical binding]; other site
754476006452	dimer interface [polypeptide binding]; other site
754476006453	ATP binding site [chemical binding]; other site
754476006454	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
754476006455	thiamine phosphate binding site [chemical binding]; other site
754476006456	active site
754476006457	pyrophosphate binding site [ion binding]; other site
754476006458	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
754476006459	ThiS interaction site; other site
754476006460	putative active site [active]
754476006461	tetramer interface [polypeptide binding]; other site
754476006462	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
754476006463	thiS-thiF/thiG interaction site; other site
754476006464	hydroxyglutarate oxidase; Provisional; Region: PRK11728
754476006465	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
754476006466	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
754476006467	ThiC-associated domain; Region: ThiC-associated; pfam13667
754476006468	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
754476006469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
754476006470	Smr domain; Region: Smr; pfam01713
754476006471	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
754476006472	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
754476006473	heme-binding site [chemical binding]; other site
754476006474	GAF domain; Region: GAF_2; pfam13185
754476006475	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006476	PAS domain; Region: PAS_9; pfam13426
754476006477	putative active site [active]
754476006478	heme pocket [chemical binding]; other site
754476006479	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476006480	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006481	metal binding site [ion binding]; metal-binding site
754476006482	active site
754476006483	I-site; other site
754476006484	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476006485	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006486	PAS domain; Region: PAS_9; pfam13426
754476006487	putative active site [active]
754476006488	heme pocket [chemical binding]; other site
754476006489	GAF domain; Region: GAF_3; pfam13492
754476006490	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476006491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476006492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006493	metal binding site [ion binding]; metal-binding site
754476006494	active site
754476006495	I-site; other site
754476006496	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476006497	GAF domain; Region: GAF; cl17456
754476006498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006499	putative active site [active]
754476006500	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
754476006501	heme pocket [chemical binding]; other site
754476006502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006503	putative active site [active]
754476006504	heme pocket [chemical binding]; other site
754476006505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476006506	putative active site [active]
754476006507	heme pocket [chemical binding]; other site
754476006508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006509	metal binding site [ion binding]; metal-binding site
754476006510	active site
754476006511	I-site; other site
754476006512	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476006513	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
754476006514	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
754476006515	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
754476006516	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
754476006517	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
754476006518	Putative serine esterase (DUF676); Region: DUF676; pfam05057
754476006519	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
754476006520	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
754476006521	catalytic residues [active]
754476006522	dimer interface [polypeptide binding]; other site
754476006523	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
754476006524	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
754476006525	Walker A/P-loop; other site
754476006526	ATP binding site [chemical binding]; other site
754476006527	Q-loop/lid; other site
754476006528	ABC transporter signature motif; other site
754476006529	Walker B; other site
754476006530	D-loop; other site
754476006531	H-loop/switch region; other site
754476006532	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
754476006533	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
754476006534	Walker A/P-loop; other site
754476006535	ATP binding site [chemical binding]; other site
754476006536	Q-loop/lid; other site
754476006537	ABC transporter signature motif; other site
754476006538	Walker B; other site
754476006539	D-loop; other site
754476006540	H-loop/switch region; other site
754476006541	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
754476006542	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
754476006543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476006544	dimer interface [polypeptide binding]; other site
754476006545	conserved gate region; other site
754476006546	putative PBP binding loops; other site
754476006547	ABC-ATPase subunit interface; other site
754476006548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
754476006549	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
754476006550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476006551	dimer interface [polypeptide binding]; other site
754476006552	conserved gate region; other site
754476006553	putative PBP binding loops; other site
754476006554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
754476006555	ABC-ATPase subunit interface; other site
754476006556	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
754476006557	peptide binding site [polypeptide binding]; other site
754476006558	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
754476006559	hypothetical protein; Provisional; Region: PRK10279
754476006560	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
754476006561	active site
754476006562	nucleophile elbow; other site
754476006563	conserved hypothetical protein; Region: MG423; TIGR00649
754476006564	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
754476006565	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
754476006566	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
754476006567	oxaloacetate decarboxylase; Provisional; Region: PRK14040
754476006568	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
754476006569	active site
754476006570	catalytic residues [active]
754476006571	metal binding site [ion binding]; metal-binding site
754476006572	homodimer binding site [polypeptide binding]; other site
754476006573	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
754476006574	carboxyltransferase (CT) interaction site; other site
754476006575	biotinylation site [posttranslational modification]; other site
754476006576	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
754476006577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476006578	RNA binding surface [nucleotide binding]; other site
754476006579	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476006580	putative DNA binding site [nucleotide binding]; other site
754476006581	putative Zn2+ binding site [ion binding]; other site
754476006582	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
754476006583	Low molecular weight phosphatase family; Region: LMWPc; cd00115
754476006584	active site
754476006585	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
754476006586	arsenical-resistance protein; Region: acr3; TIGR00832
754476006587	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
754476006588	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
754476006589	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
754476006590	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
754476006591	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
754476006592	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
754476006593	DNA binding site [nucleotide binding]
754476006594	active site
754476006595	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
754476006596	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
754476006597	FMN binding site [chemical binding]; other site
754476006598	active site
754476006599	substrate binding site [chemical binding]; other site
754476006600	catalytic residue [active]
754476006601	potassium/proton antiporter; Reviewed; Region: PRK05326
754476006602	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
754476006603	TrkA-C domain; Region: TrkA_C; pfam02080
754476006604	Transporter associated domain; Region: CorC_HlyC; smart01091
754476006605	MarC family integral membrane protein; Region: MarC; pfam01914
754476006606	Domain of unknown function (DUF305); Region: DUF305; cl17794
754476006607	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
754476006608	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
754476006609	active site
754476006610	DNA binding site [nucleotide binding]
754476006611	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
754476006612	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
754476006613	Catalytic site [active]
754476006614	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
754476006615	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
754476006616	30S subunit binding site; other site
754476006617	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
754476006618	active site
754476006619	NTP binding site [chemical binding]; other site
754476006620	metal binding triad [ion binding]; metal-binding site
754476006621	antibiotic binding site [chemical binding]; other site
754476006622	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
754476006623	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
754476006624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476006625	ATP binding site [chemical binding]; other site
754476006626	putative Mg++ binding site [ion binding]; other site
754476006627	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
754476006628	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
754476006629	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
754476006630	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
754476006631	HsdM N-terminal domain; Region: HsdM_N; pfam12161
754476006632	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
754476006633	Methyltransferase domain; Region: Methyltransf_26; pfam13659
754476006634	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
754476006635	Fic/DOC family; Region: Fic; pfam02661
754476006636	Fic/DOC family; Region: Fic; cl00960
754476006637	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
754476006638	Mrr N-terminal domain; Region: Mrr_N; pfam14338
754476006639	Restriction endonuclease; Region: Mrr_cat; pfam04471
754476006640	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
754476006641	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
754476006642	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476006643	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476006644	metal binding site [ion binding]; metal-binding site
754476006645	active site
754476006646	I-site; other site
754476006647	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
754476006648	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476006649	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476006650	Phytase; Region: Phytase; cl17685
754476006651	Phytase; Region: Phytase; cl17685
754476006652	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476006653	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476006654	TolR protein; Region: tolR; TIGR02801
754476006655	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476006656	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
754476006657	Domain of unknown function (DUF4146); Region: DUF4146; pfam13652
754476006658	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
754476006659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
754476006660	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
754476006661	methionine sulfoxide reductase B; Provisional; Region: PRK00222
754476006662	SelR domain; Region: SelR; pfam01641
754476006663	methionine sulfoxide reductase A; Provisional; Region: PRK14054
754476006664	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476006665	dimerization interface [polypeptide binding]; other site
754476006666	putative DNA binding site [nucleotide binding]; other site
754476006667	putative Zn2+ binding site [ion binding]; other site
754476006668	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
754476006669	active site
754476006670	NTP binding site [chemical binding]; other site
754476006671	metal binding triad [ion binding]; metal-binding site
754476006672	antibiotic binding site [chemical binding]; other site
754476006673	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
754476006674	Nuclease-related domain; Region: NERD; pfam08378
754476006675	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
754476006676	ATP binding site [chemical binding]; other site
754476006677	putative Mg++ binding site [ion binding]; other site
754476006678	Family description; Region: UvrD_C_2; pfam13538
754476006679	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
754476006680	SmpB-tmRNA interface; other site
754476006681	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
754476006682	Na2 binding site [ion binding]; other site
754476006683	putative substrate binding site 1 [chemical binding]; other site
754476006684	Na binding site 1 [ion binding]; other site
754476006685	putative substrate binding site 2 [chemical binding]; other site
754476006686	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
754476006687	putative coenzyme Q binding site [chemical binding]; other site
754476006688	hypothetical protein; Validated; Region: PRK01777
754476006689	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
754476006690	dinuclear metal binding motif [ion binding]; other site
754476006691	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
754476006692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476006693	dimer interface [polypeptide binding]; other site
754476006694	conserved gate region; other site
754476006695	putative PBP binding loops; other site
754476006696	ABC-ATPase subunit interface; other site
754476006697	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
754476006698	active site residue [active]
754476006699	hypothetical protein; Provisional; Region: PRK05409
754476006700	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
754476006701	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
754476006702	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
754476006703	active site
754476006704	intersubunit interface [polypeptide binding]; other site
754476006705	catalytic residue [active]
754476006706	phosphogluconate dehydratase; Validated; Region: PRK09054
754476006707	6-phosphogluconate dehydratase; Region: edd; TIGR01196
754476006708	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
754476006709	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
754476006710	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
754476006711	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
754476006712	acyl-activating enzyme (AAE) consensus motif; other site
754476006713	putative AMP binding site [chemical binding]; other site
754476006714	putative active site [active]
754476006715	putative CoA binding site [chemical binding]; other site
754476006716	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
754476006717	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
754476006718	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
754476006719	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
754476006720	substrate binding site [chemical binding]; other site
754476006721	active site
754476006722	catalytic residues [active]
754476006723	heterodimer interface [polypeptide binding]; other site
754476006724	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
754476006725	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
754476006726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006727	catalytic residue [active]
754476006728	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
754476006729	phosphate binding site [ion binding]; other site
754476006730	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
754476006731	active site
754476006732	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
754476006733	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
754476006734	dimerization interface 3.5A [polypeptide binding]; other site
754476006735	active site
754476006736	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476006737	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
754476006738	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
754476006739	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
754476006740	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
754476006741	tartrate dehydrogenase; Region: TTC; TIGR02089
754476006742	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
754476006743	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
754476006744	substrate binding site [chemical binding]; other site
754476006745	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
754476006746	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
754476006747	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476006748	ligand binding site [chemical binding]; other site
754476006749	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
754476006750	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476006751	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
754476006752	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
754476006753	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
754476006754	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
754476006755	NAD binding site [chemical binding]; other site
754476006756	homotetramer interface [polypeptide binding]; other site
754476006757	homodimer interface [polypeptide binding]; other site
754476006758	substrate binding site [chemical binding]; other site
754476006759	active site
754476006760	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
754476006761	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
754476006762	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476006763	non-specific DNA binding site [nucleotide binding]; other site
754476006764	salt bridge; other site
754476006765	sequence-specific DNA binding site [nucleotide binding]; other site
754476006766	HipA N-terminal domain; Region: Couple_hipA; cl11853
754476006767	HipA-like N-terminal domain; Region: HipA_N; pfam07805
754476006768	HipA-like C-terminal domain; Region: HipA_C; pfam07804
754476006769	periplasmic folding chaperone; Provisional; Region: PRK10788
754476006770	SurA N-terminal domain; Region: SurA_N_3; pfam13624
754476006771	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
754476006772	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
754476006773	IHF dimer interface [polypeptide binding]; other site
754476006774	IHF - DNA interface [nucleotide binding]; other site
754476006775	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
754476006776	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
754476006777	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
754476006778	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
754476006779	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
754476006780	SurA N-terminal domain; Region: SurA_N; pfam09312
754476006781	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
754476006782	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
754476006783	organic solvent tolerance protein; Provisional; Region: PRK04423
754476006784	OstA-like protein; Region: OstA; cl00844
754476006785	Organic solvent tolerance protein; Region: OstA_C; pfam04453
754476006786	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
754476006787	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
754476006788	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
754476006789	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
754476006790	multifunctional aminopeptidase A; Provisional; Region: PRK00913
754476006791	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
754476006792	interface (dimer of trimers) [polypeptide binding]; other site
754476006793	Substrate-binding/catalytic site; other site
754476006794	Zn-binding sites [ion binding]; other site
754476006795	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
754476006796	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
754476006797	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
754476006798	HIGH motif; other site
754476006799	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
754476006800	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
754476006801	active site
754476006802	KMSKS motif; other site
754476006803	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
754476006804	tRNA binding surface [nucleotide binding]; other site
754476006805	anticodon binding site; other site
754476006806	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
754476006807	hypothetical protein; Validated; Region: PRK00029
754476006808	Uncharacterized conserved protein [Function unknown]; Region: COG0397
754476006809	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
754476006810	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
754476006811	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
754476006812	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
754476006813	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
754476006814	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
754476006815	Predicted dehydrogenase [General function prediction only]; Region: COG0579
754476006816	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
754476006817	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
754476006818	metal ion-dependent adhesion site (MIDAS); other site
754476006819	TIGR03503 family protein; Region: TIGR03503
754476006820	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
754476006821	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
754476006822	homodimer interface [polypeptide binding]; other site
754476006823	substrate-cofactor binding pocket; other site
754476006824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006825	catalytic residue [active]
754476006826	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
754476006827	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
754476006828	N-terminal plug; other site
754476006829	ligand-binding site [chemical binding]; other site
754476006830	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
754476006831	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
754476006832	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
754476006833	catalytic triad [active]
754476006834	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
754476006835	putative FMN binding site [chemical binding]; other site
754476006836	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
754476006837	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
754476006838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476006839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476006840	homodimer interface [polypeptide binding]; other site
754476006841	catalytic residue [active]
754476006842	cobyric acid synthase; Provisional; Region: PRK00784
754476006843	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
754476006844	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
754476006845	catalytic triad [active]
754476006846	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
754476006847	homotrimer interface [polypeptide binding]; other site
754476006848	Walker A motif; other site
754476006849	GTP binding site [chemical binding]; other site
754476006850	Walker B motif; other site
754476006851	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
754476006852	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
754476006853	putative dimer interface [polypeptide binding]; other site
754476006854	active site pocket [active]
754476006855	putative cataytic base [active]
754476006856	cobalamin synthase; Reviewed; Region: cobS; PRK00235
754476006857	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
754476006858	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
754476006859	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
754476006860	homodimer interface [polypeptide binding]; other site
754476006861	Walker A motif; other site
754476006862	ATP binding site [chemical binding]; other site
754476006863	hydroxycobalamin binding site [chemical binding]; other site
754476006864	Walker B motif; other site
754476006865	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
754476006866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476006867	Walker A motif; other site
754476006868	ATP binding site [chemical binding]; other site
754476006869	Walker B motif; other site
754476006870	arginine finger; other site
754476006871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476006872	Walker A motif; other site
754476006873	ATP binding site [chemical binding]; other site
754476006874	Walker B motif; other site
754476006875	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
754476006876	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
754476006877	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
754476006878	putative GSH binding site [chemical binding]; other site
754476006879	catalytic residues [active]
754476006880	phosphoserine phosphatase SerB; Region: serB; TIGR00338
754476006881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476006882	motif II; other site
754476006883	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
754476006884	dimer interface [polypeptide binding]; other site
754476006885	substrate binding site [chemical binding]; other site
754476006886	metal binding sites [ion binding]; metal-binding site
754476006887	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
754476006888	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
754476006889	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
754476006890	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
754476006891	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
754476006892	active site
754476006893	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
754476006894	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
754476006895	prolyl-tRNA synthetase; Provisional; Region: PRK09194
754476006896	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
754476006897	dimer interface [polypeptide binding]; other site
754476006898	motif 1; other site
754476006899	active site
754476006900	motif 2; other site
754476006901	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
754476006902	putative deacylase active site [active]
754476006903	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
754476006904	active site
754476006905	motif 3; other site
754476006906	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
754476006907	anticodon binding site; other site
754476006908	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
754476006909	Fumarase C-terminus; Region: Fumerase_C; pfam05683
754476006910	Predicted integral membrane protein [Function unknown]; Region: COG5615
754476006911	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
754476006912	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476006913	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476006914	catalytic residue [active]
754476006915	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
754476006916	putative active site [active]
754476006917	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
754476006918	catalytic motif [active]
754476006919	Catalytic residue [active]
754476006920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
754476006921	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
754476006922	putative metal binding site [ion binding]; other site
754476006923	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
754476006924	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
754476006925	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
754476006926	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
754476006927	Soluble P-type ATPase [General function prediction only]; Region: COG4087
754476006928	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
754476006929	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
754476006930	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
754476006931	putative NAD(P) binding site [chemical binding]; other site
754476006932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
754476006933	SEC-C motif; Region: SEC-C; pfam02810
754476006934	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
754476006935	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
754476006936	putative acyl-acceptor binding pocket; other site
754476006937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
754476006938	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
754476006939	tetramerization interface [polypeptide binding]; other site
754476006940	active site
754476006941	Pantoate-beta-alanine ligase; Region: PanC; cd00560
754476006942	pantoate--beta-alanine ligase; Region: panC; TIGR00018
754476006943	active site
754476006944	ATP-binding site [chemical binding]; other site
754476006945	pantoate-binding site; other site
754476006946	HXXH motif; other site
754476006947	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
754476006948	oligomerization interface [polypeptide binding]; other site
754476006949	active site
754476006950	metal binding site [ion binding]; metal-binding site
754476006951	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
754476006952	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
754476006953	Substrate-binding site [chemical binding]; other site
754476006954	Substrate specificity [chemical binding]; other site
754476006955	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
754476006956	catalytic center binding site [active]
754476006957	ATP binding site [chemical binding]; other site
754476006958	poly(A) polymerase; Region: pcnB; TIGR01942
754476006959	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
754476006960	active site
754476006961	NTP binding site [chemical binding]; other site
754476006962	metal binding triad [ion binding]; metal-binding site
754476006963	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
754476006964	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
754476006965	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
754476006966	RNA/DNA hybrid binding site [nucleotide binding]; other site
754476006967	active site
754476006968	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
754476006969	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
754476006970	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
754476006971	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
754476006972	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
754476006973	dimerization interface [polypeptide binding]; other site
754476006974	active site
754476006975	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
754476006976	Lumazine binding domain; Region: Lum_binding; pfam00677
754476006977	Lumazine binding domain; Region: Lum_binding; pfam00677
754476006978	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
754476006979	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
754476006980	catalytic motif [active]
754476006981	Zn binding site [ion binding]; other site
754476006982	RibD C-terminal domain; Region: RibD_C; cl17279
754476006983	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
754476006984	ATP cone domain; Region: ATP-cone; pfam03477
754476006985	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
754476006986	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
754476006987	dimer interface [polypeptide binding]; other site
754476006988	active site
754476006989	glycine-pyridoxal phosphate binding site [chemical binding]; other site
754476006990	folate binding site [chemical binding]; other site
754476006991	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
754476006992	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
754476006993	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
754476006994	GDP-binding site [chemical binding]; other site
754476006995	ACT binding site; other site
754476006996	IMP binding site; other site
754476006997	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
754476006998	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
754476006999	dimer interface [polypeptide binding]; other site
754476007000	motif 1; other site
754476007001	active site
754476007002	motif 2; other site
754476007003	motif 3; other site
754476007004	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
754476007005	FtsH protease regulator HflC; Provisional; Region: PRK11029
754476007006	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
754476007007	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
754476007008	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
754476007009	HflK protein; Region: hflK; TIGR01933
754476007010	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
754476007011	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
754476007012	HflX GTPase family; Region: HflX; cd01878
754476007013	G1 box; other site
754476007014	GTP/Mg2+ binding site [chemical binding]; other site
754476007015	Switch I region; other site
754476007016	G2 box; other site
754476007017	G3 box; other site
754476007018	Switch II region; other site
754476007019	G4 box; other site
754476007020	G5 box; other site
754476007021	bacterial Hfq-like; Region: Hfq; cd01716
754476007022	hexamer interface [polypeptide binding]; other site
754476007023	Sm1 motif; other site
754476007024	RNA binding site [nucleotide binding]; other site
754476007025	Sm2 motif; other site
754476007026	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
754476007027	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
754476007028	transcription termination factor Rho; Provisional; Region: rho; PRK09376
754476007029	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
754476007030	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
754476007031	RNA binding site [nucleotide binding]; other site
754476007032	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
754476007033	multimer interface [polypeptide binding]; other site
754476007034	Walker A motif; other site
754476007035	ATP binding site [chemical binding]; other site
754476007036	Walker B motif; other site
754476007037	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
754476007038	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
754476007039	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
754476007040	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
754476007041	alphaNTD homodimer interface [polypeptide binding]; other site
754476007042	alphaNTD - beta interaction site [polypeptide binding]; other site
754476007043	alphaNTD - beta' interaction site [polypeptide binding]; other site
754476007044	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
754476007045	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
754476007046	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
754476007047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476007048	RNA binding surface [nucleotide binding]; other site
754476007049	30S ribosomal protein S11; Validated; Region: PRK05309
754476007050	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
754476007051	30S ribosomal protein S13; Region: bact_S13; TIGR03631
754476007052	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
754476007053	SecY translocase; Region: SecY; pfam00344
754476007054	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
754476007055	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
754476007056	23S rRNA binding site [nucleotide binding]; other site
754476007057	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
754476007058	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
754476007059	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
754476007060	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
754476007061	23S rRNA interface [nucleotide binding]; other site
754476007062	5S rRNA interface [nucleotide binding]; other site
754476007063	L27 interface [polypeptide binding]; other site
754476007064	L5 interface [polypeptide binding]; other site
754476007065	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
754476007066	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
754476007067	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
754476007068	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
754476007069	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
754476007070	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
754476007071	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
754476007072	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
754476007073	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
754476007074	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
754476007075	RNA binding site [nucleotide binding]; other site
754476007076	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
754476007077	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
754476007078	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
754476007079	23S rRNA interface [nucleotide binding]; other site
754476007080	putative translocon interaction site; other site
754476007081	signal recognition particle (SRP54) interaction site; other site
754476007082	L23 interface [polypeptide binding]; other site
754476007083	trigger factor interaction site; other site
754476007084	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
754476007085	23S rRNA interface [nucleotide binding]; other site
754476007086	5S rRNA interface [nucleotide binding]; other site
754476007087	putative antibiotic binding site [chemical binding]; other site
754476007088	L25 interface [polypeptide binding]; other site
754476007089	L27 interface [polypeptide binding]; other site
754476007090	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
754476007091	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
754476007092	G-X-X-G motif; other site
754476007093	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
754476007094	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
754476007095	putative translocon binding site; other site
754476007096	protein-rRNA interface [nucleotide binding]; other site
754476007097	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
754476007098	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
754476007099	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
754476007100	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
754476007101	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
754476007102	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
754476007103	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
754476007104	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
754476007105	elongation factor Tu; Reviewed; Region: PRK00049
754476007106	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
754476007107	G1 box; other site
754476007108	GEF interaction site [polypeptide binding]; other site
754476007109	GTP/Mg2+ binding site [chemical binding]; other site
754476007110	Switch I region; other site
754476007111	G2 box; other site
754476007112	G3 box; other site
754476007113	Switch II region; other site
754476007114	G4 box; other site
754476007115	G5 box; other site
754476007116	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
754476007117	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
754476007118	Antibiotic Binding Site [chemical binding]; other site
754476007119	elongation factor G; Reviewed; Region: PRK00007
754476007120	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
754476007121	G1 box; other site
754476007122	putative GEF interaction site [polypeptide binding]; other site
754476007123	GTP/Mg2+ binding site [chemical binding]; other site
754476007124	Switch I region; other site
754476007125	G2 box; other site
754476007126	G3 box; other site
754476007127	Switch II region; other site
754476007128	G4 box; other site
754476007129	G5 box; other site
754476007130	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
754476007131	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
754476007132	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
754476007133	30S ribosomal protein S7; Validated; Region: PRK05302
754476007134	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
754476007135	S17 interaction site [polypeptide binding]; other site
754476007136	S8 interaction site; other site
754476007137	16S rRNA interaction site [nucleotide binding]; other site
754476007138	streptomycin interaction site [chemical binding]; other site
754476007139	23S rRNA interaction site [nucleotide binding]; other site
754476007140	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
754476007141	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
754476007142	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
754476007143	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
754476007144	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
754476007145	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
754476007146	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
754476007147	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
754476007148	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
754476007149	DNA binding site [nucleotide binding]
754476007150	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
754476007151	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
754476007152	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
754476007153	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
754476007154	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
754476007155	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
754476007156	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
754476007157	RPB3 interaction site [polypeptide binding]; other site
754476007158	RPB1 interaction site [polypeptide binding]; other site
754476007159	RPB11 interaction site [polypeptide binding]; other site
754476007160	RPB10 interaction site [polypeptide binding]; other site
754476007161	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
754476007162	peripheral dimer interface [polypeptide binding]; other site
754476007163	core dimer interface [polypeptide binding]; other site
754476007164	L10 interface [polypeptide binding]; other site
754476007165	L11 interface [polypeptide binding]; other site
754476007166	putative EF-Tu interaction site [polypeptide binding]; other site
754476007167	putative EF-G interaction site [polypeptide binding]; other site
754476007168	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
754476007169	23S rRNA interface [nucleotide binding]; other site
754476007170	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
754476007171	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
754476007172	mRNA/rRNA interface [nucleotide binding]; other site
754476007173	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
754476007174	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
754476007175	23S rRNA interface [nucleotide binding]; other site
754476007176	L7/L12 interface [polypeptide binding]; other site
754476007177	putative thiostrepton binding site; other site
754476007178	L25 interface [polypeptide binding]; other site
754476007179	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
754476007180	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
754476007181	putative homodimer interface [polypeptide binding]; other site
754476007182	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
754476007183	heterodimer interface [polypeptide binding]; other site
754476007184	homodimer interface [polypeptide binding]; other site
754476007185	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
754476007186	elongation factor Tu; Reviewed; Region: PRK00049
754476007187	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
754476007188	G1 box; other site
754476007189	GEF interaction site [polypeptide binding]; other site
754476007190	GTP/Mg2+ binding site [chemical binding]; other site
754476007191	Switch I region; other site
754476007192	G2 box; other site
754476007193	G3 box; other site
754476007194	Switch II region; other site
754476007195	G4 box; other site
754476007196	G5 box; other site
754476007197	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
754476007198	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
754476007199	Antibiotic Binding Site [chemical binding]; other site
754476007200	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
754476007201	active site
754476007202	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
754476007203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476007204	Walker A motif; other site
754476007205	ATP binding site [chemical binding]; other site
754476007206	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
754476007207	Walker B motif; other site
754476007208	arginine finger; other site
754476007209	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
754476007210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
754476007211	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
754476007212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476007213	S-adenosylmethionine binding site [chemical binding]; other site
754476007214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
754476007215	SCP-2 sterol transfer family; Region: SCP2; pfam02036
754476007216	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
754476007217	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
754476007218	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
754476007219	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
754476007220	Potassium binding sites [ion binding]; other site
754476007221	Cesium cation binding sites [ion binding]; other site
754476007222	aromatic acid decarboxylase; Validated; Region: PRK05920
754476007223	Flavoprotein; Region: Flavoprotein; pfam02441
754476007224	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
754476007225	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
754476007226	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
754476007227	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
754476007228	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
754476007229	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476007230	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476007231	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476007232	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
754476007233	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
754476007234	Protein export membrane protein; Region: SecD_SecF; pfam02355
754476007235	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
754476007236	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
754476007237	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
754476007238	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
754476007239	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
754476007240	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
754476007241	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
754476007242	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
754476007243	active site
754476007244	dimer interface [polypeptide binding]; other site
754476007245	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476007246	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476007247	dimer interface [polypeptide binding]; other site
754476007248	putative CheW interface [polypeptide binding]; other site
754476007249	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
754476007250	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
754476007251	heme-binding site [chemical binding]; other site
754476007252	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
754476007253	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476007254	P-loop; other site
754476007255	Magnesium ion binding site [ion binding]; other site
754476007256	CheW-like domain; Region: CheW; pfam01584
754476007257	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
754476007258	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
754476007259	putative binding surface; other site
754476007260	active site
754476007261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476007262	ATP binding site [chemical binding]; other site
754476007263	Mg2+ binding site [ion binding]; other site
754476007264	G-X-G motif; other site
754476007265	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
754476007266	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476007267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007268	active site
754476007269	phosphorylation site [posttranslational modification]
754476007270	intermolecular recognition site; other site
754476007271	dimerization interface [polypeptide binding]; other site
754476007272	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
754476007273	Flagellar FliJ protein; Region: FliJ; pfam02050
754476007274	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
754476007275	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
754476007276	Walker A motif/ATP binding site; other site
754476007277	Walker B motif; other site
754476007278	flagellar assembly protein H; Validated; Region: fliH; PRK05687
754476007279	Flagellar assembly protein FliH; Region: FliH; pfam02108
754476007280	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
754476007281	FliG C-terminal domain; Region: FliG_C; pfam01706
754476007282	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
754476007283	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
754476007284	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
754476007285	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
754476007286	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476007287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007288	active site
754476007289	phosphorylation site [posttranslational modification]
754476007290	intermolecular recognition site; other site
754476007291	dimerization interface [polypeptide binding]; other site
754476007292	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476007293	Walker A motif; other site
754476007294	ATP binding site [chemical binding]; other site
754476007295	Walker B motif; other site
754476007296	arginine finger; other site
754476007297	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476007298	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476007299	dimer interface [polypeptide binding]; other site
754476007300	phosphorylation site [posttranslational modification]
754476007301	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476007302	ATP binding site [chemical binding]; other site
754476007303	G-X-G motif; other site
754476007304	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
754476007305	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
754476007306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476007307	Walker A motif; other site
754476007308	ATP binding site [chemical binding]; other site
754476007309	Walker B motif; other site
754476007310	arginine finger; other site
754476007311	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
754476007312	Flagellar protein FliT; Region: FliT; pfam05400
754476007313	flagellar protein FliS; Validated; Region: fliS; PRK05685
754476007314	flagellar capping protein; Reviewed; Region: fliD; PRK08032
754476007315	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
754476007316	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
754476007317	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
754476007318	FlaG protein; Region: FlaG; pfam03646
754476007319	flagellin; Provisional; Region: PRK12802
754476007320	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
754476007321	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
754476007322	flagellin; Provisional; Region: PRK12802
754476007323	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
754476007324	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
754476007325	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
754476007326	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
754476007327	active site
754476007328	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
754476007329	active site
754476007330	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
754476007331	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
754476007332	Probable Catalytic site; other site
754476007333	metal-binding site
754476007334	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
754476007335	Cephalosporin hydroxylase; Region: CmcI; pfam04989
754476007336	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
754476007337	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476007338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476007339	S-adenosylmethionine binding site [chemical binding]; other site
754476007340	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
754476007341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476007342	FeS/SAM binding site; other site
754476007343	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
754476007344	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
754476007345	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476007346	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
754476007347	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
754476007348	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476007349	FeS/SAM binding site; other site
754476007350	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
754476007351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476007352	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
754476007353	NAD(P) binding site [chemical binding]; other site
754476007354	active site
754476007355	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
754476007356	Methyltransferase domain; Region: Methyltransf_23; pfam13489
754476007357	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
754476007358	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
754476007359	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
754476007360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476007361	NAD(P) binding site [chemical binding]; other site
754476007362	active site
754476007363	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
754476007364	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
754476007365	substrate binding site; other site
754476007366	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
754476007367	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
754476007368	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
754476007369	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
754476007370	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
754476007371	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
754476007372	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
754476007373	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
754476007374	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
754476007375	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
754476007376	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
754476007377	Flagellar L-ring protein; Region: FlgH; pfam02107
754476007378	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
754476007379	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
754476007380	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
754476007381	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
754476007382	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
754476007383	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
754476007384	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
754476007385	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
754476007386	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
754476007387	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
754476007388	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
754476007389	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
754476007390	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
754476007391	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
754476007392	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
754476007393	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
754476007394	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
754476007395	Type II transport protein GspH; Region: GspH; pfam12019
754476007396	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
754476007397	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
754476007398	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
754476007399	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
754476007400	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
754476007401	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
754476007402	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
754476007403	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
754476007404	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
754476007405	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476007406	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476007407	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
754476007408	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
754476007409	division inhibitor protein; Provisional; Region: slmA; PRK09480
754476007410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476007411	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
754476007412	feedback inhibition sensing region; other site
754476007413	homohexameric interface [polypeptide binding]; other site
754476007414	carbamate kinase; Reviewed; Region: PRK12686
754476007415	nucleotide binding site [chemical binding]; other site
754476007416	N-acetyl-L-glutamate binding site [chemical binding]; other site
754476007417	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
754476007418	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
754476007419	active site
754476007420	substrate binding site [chemical binding]; other site
754476007421	metal binding site [ion binding]; metal-binding site
754476007422	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
754476007423	trimer interface [polypeptide binding]; other site
754476007424	active site
754476007425	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
754476007426	Flavoprotein; Region: Flavoprotein; pfam02441
754476007427	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
754476007428	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
754476007429	Uncharacterized conserved protein [Function unknown]; Region: COG0327
754476007430	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
754476007431	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
754476007432	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
754476007433	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
754476007434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476007435	short chain dehydrogenase; Provisional; Region: PRK05993
754476007436	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
754476007437	NADP binding site [chemical binding]; other site
754476007438	active site
754476007439	steroid binding site; other site
754476007440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
754476007441	Transposase; Region: HTH_Tnp_1; pfam01527
754476007442	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
754476007443	cyanate hydratase; Validated; Region: PRK02866
754476007444	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
754476007445	oligomer interface [polypeptide binding]; other site
754476007446	active site
754476007447	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
754476007448	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
754476007449	Clp amino terminal domain; Region: Clp_N; pfam02861
754476007450	Clp amino terminal domain; Region: Clp_N; pfam02861
754476007451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476007452	Walker A motif; other site
754476007453	ATP binding site [chemical binding]; other site
754476007454	Walker B motif; other site
754476007455	arginine finger; other site
754476007456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476007457	Walker A motif; other site
754476007458	ATP binding site [chemical binding]; other site
754476007459	Walker B motif; other site
754476007460	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
754476007461	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
754476007462	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
754476007463	putative acyl-acceptor binding pocket; other site
754476007464	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
754476007465	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
754476007466	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476007467	putative ADP-binding pocket [chemical binding]; other site
754476007468	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476007469	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
754476007470	putative ADP-binding pocket [chemical binding]; other site
754476007471	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
754476007472	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
754476007473	putative active site [active]
754476007474	O-Antigen ligase; Region: Wzy_C; pfam04932
754476007475	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
754476007476	putative acyl-acceptor binding pocket; other site
754476007477	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
754476007478	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
754476007479	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
754476007480	active site
754476007481	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
754476007482	intracellular septation protein A; Reviewed; Region: PRK00259
754476007483	YciI-like protein; Reviewed; Region: PRK11370
754476007484	BolA-like protein; Region: BolA; pfam01722
754476007485	PilZ domain; Region: PilZ; pfam07238
754476007486	peptidase PmbA; Provisional; Region: PRK11040
754476007487	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
754476007488	MPN+ (JAMM) motif; other site
754476007489	Zinc-binding site [ion binding]; other site
754476007490	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
754476007491	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
754476007492	ATP binding site [chemical binding]; other site
754476007493	substrate interface [chemical binding]; other site
754476007494	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
754476007495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476007496	S-adenosylmethionine binding site [chemical binding]; other site
754476007497	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476007498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007499	active site
754476007500	phosphorylation site [posttranslational modification]
754476007501	intermolecular recognition site; other site
754476007502	dimerization interface [polypeptide binding]; other site
754476007503	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
754476007504	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
754476007505	RNA methyltransferase, RsmE family; Region: TIGR00046
754476007506	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
754476007507	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
754476007508	active site
754476007509	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
754476007510	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
754476007511	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
754476007512	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
754476007513	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
754476007514	putative active site [active]
754476007515	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
754476007516	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476007517	putative ADP-binding pocket [chemical binding]; other site
754476007518	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
754476007519	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
754476007520	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
754476007521	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
754476007522	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
754476007523	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
754476007524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
754476007525	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
754476007526	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
754476007527	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
754476007528	dimer interface [polypeptide binding]; other site
754476007529	active site
754476007530	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
754476007531	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
754476007532	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
754476007533	active site
754476007534	catalytic tetrad [active]
754476007535	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
754476007536	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
754476007537	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
754476007538	CcdB protein; Region: CcdB; cl03380
754476007539	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
754476007540	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
754476007541	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
754476007542	putative ribose interaction site [chemical binding]; other site
754476007543	putative ADP binding site [chemical binding]; other site
754476007544	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
754476007545	active site
754476007546	nucleotide binding site [chemical binding]; other site
754476007547	HIGH motif; other site
754476007548	KMSKS motif; other site
754476007549	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
754476007550	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
754476007551	putative active site [active]
754476007552	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
754476007553	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
754476007554	putative active site [active]
754476007555	putative substrate binding site [chemical binding]; other site
754476007556	ATP binding site [chemical binding]; other site
754476007557	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
754476007558	DNA polymerase I; Provisional; Region: PRK05755
754476007559	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
754476007560	active site
754476007561	metal binding site 1 [ion binding]; metal-binding site
754476007562	putative 5' ssDNA interaction site; other site
754476007563	metal binding site 3; metal-binding site
754476007564	metal binding site 2 [ion binding]; metal-binding site
754476007565	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
754476007566	putative DNA binding site [nucleotide binding]; other site
754476007567	putative metal binding site [ion binding]; other site
754476007568	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
754476007569	active site
754476007570	catalytic site [active]
754476007571	substrate binding site [chemical binding]; other site
754476007572	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
754476007573	active site
754476007574	DNA binding site [nucleotide binding]
754476007575	catalytic site [active]
754476007576	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
754476007577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476007578	dimer interface [polypeptide binding]; other site
754476007579	putative CheW interface [polypeptide binding]; other site
754476007580	epoxyqueuosine reductase; Region: TIGR00276
754476007581	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
754476007582	putative carbohydrate kinase; Provisional; Region: PRK10565
754476007583	Uncharacterized conserved protein [Function unknown]; Region: COG0062
754476007584	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
754476007585	putative substrate binding site [chemical binding]; other site
754476007586	putative ATP binding site [chemical binding]; other site
754476007587	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
754476007588	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
754476007589	AMIN domain; Region: AMIN; pfam11741
754476007590	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
754476007591	active site
754476007592	metal binding site [ion binding]; metal-binding site
754476007593	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
754476007594	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
754476007595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476007596	Mg2+ binding site [ion binding]; other site
754476007597	G-X-G motif; other site
754476007598	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
754476007599	ATP binding site [chemical binding]; other site
754476007600	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
754476007601	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
754476007602	Protein export membrane protein; Region: SecD_SecF; cl14618
754476007603	Gram-negative porin; Region: Porin_4; pfam13609
754476007604	DAK2 domain; Region: Dak2; cl03685
754476007605	GxxExxY protein; Region: GxxExxY; TIGR04256
754476007606	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
754476007607	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
754476007608	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
754476007609	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476007610	active site
754476007611	motif I; other site
754476007612	motif II; other site
754476007613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476007614	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
754476007615	phosphate binding site [ion binding]; other site
754476007616	transaldolase-like protein; Provisional; Region: PTZ00411
754476007617	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
754476007618	active site
754476007619	dimer interface [polypeptide binding]; other site
754476007620	catalytic residue [active]
754476007621	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
754476007622	active site
754476007623	dimer interface [polypeptide binding]; other site
754476007624	magnesium binding site [ion binding]; other site
754476007625	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
754476007626	tetramer interface [polypeptide binding]; other site
754476007627	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
754476007628	active site
754476007629	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
754476007630	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
754476007631	substrate binding site [chemical binding]; other site
754476007632	ligand binding site [chemical binding]; other site
754476007633	HemK family putative methylases; Region: hemK_fam; TIGR00536
754476007634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476007635	S-adenosylmethionine binding site [chemical binding]; other site
754476007636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007637	active site
754476007638	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
754476007639	phosphorylation site [posttranslational modification]
754476007640	intermolecular recognition site; other site
754476007641	dimerization interface [polypeptide binding]; other site
754476007642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007643	active site
754476007644	phosphorylation site [posttranslational modification]
754476007645	intermolecular recognition site; other site
754476007646	dimerization interface [polypeptide binding]; other site
754476007647	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007648	metal binding site [ion binding]; metal-binding site
754476007649	active site
754476007650	I-site; other site
754476007651	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
754476007652	putative DNA-binding cleft [nucleotide binding]; other site
754476007653	putative DNA clevage site; other site
754476007654	molecular lever; other site
754476007655	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
754476007656	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476007657	Walker A/P-loop; other site
754476007658	ATP binding site [chemical binding]; other site
754476007659	Q-loop/lid; other site
754476007660	ABC transporter signature motif; other site
754476007661	Walker B; other site
754476007662	D-loop; other site
754476007663	H-loop/switch region; other site
754476007664	inner membrane transport permease; Provisional; Region: PRK15066
754476007665	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476007666	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
754476007667	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
754476007668	FMN binding site [chemical binding]; other site
754476007669	active site
754476007670	catalytic residues [active]
754476007671	substrate binding site [chemical binding]; other site
754476007672	Protein of unknown function DUF45; Region: DUF45; pfam01863
754476007673	S-adenosylmethionine synthetase; Validated; Region: PRK05250
754476007674	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
754476007675	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
754476007676	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
754476007677	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
754476007678	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
754476007679	homotetramer interface [polypeptide binding]; other site
754476007680	ligand binding site [chemical binding]; other site
754476007681	catalytic site [active]
754476007682	NAD binding site [chemical binding]; other site
754476007683	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
754476007684	FAD binding site [chemical binding]; other site
754476007685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476007686	dimer interface [polypeptide binding]; other site
754476007687	conserved gate region; other site
754476007688	putative PBP binding loops; other site
754476007689	ABC-ATPase subunit interface; other site
754476007690	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
754476007691	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476007692	Walker A/P-loop; other site
754476007693	ATP binding site [chemical binding]; other site
754476007694	Q-loop/lid; other site
754476007695	ABC transporter signature motif; other site
754476007696	Walker B; other site
754476007697	D-loop; other site
754476007698	H-loop/switch region; other site
754476007699	TOBE domain; Region: TOBE; pfam03459
754476007700	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
754476007701	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
754476007702	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
754476007703	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
754476007704	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
754476007705	30S subunit binding site; other site
754476007706	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
754476007707	active site
754476007708	phosphorylation site [posttranslational modification]
754476007709	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
754476007710	Hpr binding site; other site
754476007711	active site
754476007712	homohexamer subunit interaction site [polypeptide binding]; other site
754476007713	active pocket/dimerization site; other site
754476007714	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
754476007715	active site
754476007716	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
754476007717	dimerization domain swap beta strand [polypeptide binding]; other site
754476007718	regulatory protein interface [polypeptide binding]; other site
754476007719	active site
754476007720	regulatory phosphorylation site [posttranslational modification]; other site
754476007721	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
754476007722	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
754476007723	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
754476007724	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
754476007725	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476007726	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476007727	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
754476007728	MgtE intracellular N domain; Region: MgtE_N; smart00924
754476007729	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
754476007730	Divalent cation transporter; Region: MgtE; pfam01769
754476007731	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
754476007732	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
754476007733	Tetramer interface [polypeptide binding]; other site
754476007734	active site
754476007735	FMN-binding site [chemical binding]; other site
754476007736	phenyl proprionate permease family protein; Region: 2A0127; TIGR00902
754476007737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476007738	putative substrate translocation pore; other site
754476007739	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
754476007740	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
754476007741	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
754476007742	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
754476007743	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
754476007744	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
754476007745	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
754476007746	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
754476007747	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
754476007748	catalytic loop [active]
754476007749	iron binding site [ion binding]; other site
754476007750	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
754476007751	FAD binding pocket [chemical binding]; other site
754476007752	FAD binding motif [chemical binding]; other site
754476007753	phosphate binding motif [ion binding]; other site
754476007754	beta-alpha-beta structure motif; other site
754476007755	NAD binding pocket [chemical binding]; other site
754476007756	Protein of unknown function (DUF539); Region: DUF539; cl01129
754476007757	FOG: CBS domain [General function prediction only]; Region: COG0517
754476007758	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
754476007759	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
754476007760	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
754476007761	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
754476007762	dimer interface [polypeptide binding]; other site
754476007763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476007764	catalytic residue [active]
754476007765	PAS domain S-box; Region: sensory_box; TIGR00229
754476007766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007767	putative active site [active]
754476007768	heme pocket [chemical binding]; other site
754476007769	GAF domain; Region: GAF; cl17456
754476007770	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007771	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007772	metal binding site [ion binding]; metal-binding site
754476007773	active site
754476007774	I-site; other site
754476007775	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
754476007776	Cupin domain; Region: Cupin_2; cl17218
754476007777	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
754476007778	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
754476007779	active site
754476007780	HIGH motif; other site
754476007781	dimer interface [polypeptide binding]; other site
754476007782	KMSKS motif; other site
754476007783	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476007784	RNA binding surface [nucleotide binding]; other site
754476007785	putative peptidase; Provisional; Region: PRK11649
754476007786	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
754476007787	Peptidase family M23; Region: Peptidase_M23; pfam01551
754476007788	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
754476007789	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
754476007790	lipoyl attachment site [posttranslational modification]; other site
754476007791	4-alpha-glucanotransferase; Provisional; Region: PRK14508
754476007792	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
754476007793	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
754476007794	putative active site [active]
754476007795	catalytic site [active]
754476007796	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
754476007797	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
754476007798	ligand binding site; other site
754476007799	oligomer interface; other site
754476007800	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
754476007801	dimer interface [polypeptide binding]; other site
754476007802	N-terminal domain interface [polypeptide binding]; other site
754476007803	sulfate 1 binding site; other site
754476007804	glycogen branching enzyme; Provisional; Region: PRK05402
754476007805	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
754476007806	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
754476007807	active site
754476007808	catalytic site [active]
754476007809	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
754476007810	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
754476007811	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
754476007812	active site
754476007813	dimer interface [polypeptide binding]; other site
754476007814	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
754476007815	dimer interface [polypeptide binding]; other site
754476007816	active site
754476007817	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
754476007818	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
754476007819	dimer interface [polypeptide binding]; other site
754476007820	motif 1; other site
754476007821	active site
754476007822	motif 2; other site
754476007823	motif 3; other site
754476007824	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
754476007825	anticodon binding site; other site
754476007826	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
754476007827	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
754476007828	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
754476007829	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
754476007830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476007831	binding surface
754476007832	TPR motif; other site
754476007833	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
754476007834	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476007835	FeS/SAM binding site; other site
754476007836	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
754476007837	active site
754476007838	multimer interface [polypeptide binding]; other site
754476007839	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
754476007840	ATP-NAD kinase; Region: NAD_kinase; pfam01513
754476007841	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
754476007842	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
754476007843	Walker A/P-loop; other site
754476007844	ATP binding site [chemical binding]; other site
754476007845	Q-loop/lid; other site
754476007846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476007847	ABC transporter signature motif; other site
754476007848	Walker B; other site
754476007849	D-loop; other site
754476007850	H-loop/switch region; other site
754476007851	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
754476007852	metal binding site 2 [ion binding]; metal-binding site
754476007853	putative DNA binding helix; other site
754476007854	metal binding site 1 [ion binding]; metal-binding site
754476007855	dimer interface [polypeptide binding]; other site
754476007856	structural Zn2+ binding site [ion binding]; other site
754476007857	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
754476007858	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
754476007859	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
754476007860	active site clefts [active]
754476007861	zinc binding site [ion binding]; other site
754476007862	dimer interface [polypeptide binding]; other site
754476007863	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
754476007864	AAA domain; Region: AAA_32; pfam13654
754476007865	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
754476007866	PilZ domain; Region: PilZ; pfam07238
754476007867	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
754476007868	diiron binding motif [ion binding]; other site
754476007869	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007870	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007871	metal binding site [ion binding]; metal-binding site
754476007872	active site
754476007873	I-site; other site
754476007874	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
754476007875	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
754476007876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476007877	active site
754476007878	phosphorylation site [posttranslational modification]
754476007879	intermolecular recognition site; other site
754476007880	dimerization interface [polypeptide binding]; other site
754476007881	ribonuclease R; Region: RNase_R; TIGR02063
754476007882	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
754476007883	RNB domain; Region: RNB; pfam00773
754476007884	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
754476007885	RNA binding site [nucleotide binding]; other site
754476007886	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007887	PAS fold; Region: PAS_3; pfam08447
754476007888	putative active site [active]
754476007889	heme pocket [chemical binding]; other site
754476007890	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476007891	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476007892	dimer interface [polypeptide binding]; other site
754476007893	putative CheW interface [polypeptide binding]; other site
754476007894	glutamate dehydrogenase; Provisional; Region: PRK09414
754476007895	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
754476007896	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
754476007897	NAD(P) binding pocket [chemical binding]; other site
754476007898	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
754476007899	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
754476007900	Trp docking motif [polypeptide binding]; other site
754476007901	active site
754476007902	Isochorismatase family; Region: Isochorismatase; pfam00857
754476007903	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
754476007904	catalytic triad [active]
754476007905	conserved cis-peptide bond; other site
754476007906	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
754476007907	putative heme binding pocket [chemical binding]; other site
754476007908	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
754476007909	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
754476007910	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
754476007911	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
754476007912	putative NAD(P) binding site [chemical binding]; other site
754476007913	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
754476007914	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
754476007915	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
754476007916	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
754476007917	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
754476007918	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
754476007919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
754476007920	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
754476007921	WYL domain; Region: WYL; pfam13280
754476007922	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
754476007923	Protein phosphatase 2C; Region: PP2C; pfam00481
754476007924	active site
754476007925	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
754476007926	Catalytic domain of Protein Kinases; Region: PKc; cd00180
754476007927	active site
754476007928	substrate binding site [chemical binding]; other site
754476007929	ATP binding site [chemical binding]; other site
754476007930	activation loop (A-loop); other site
754476007931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476007932	putative substrate translocation pore; other site
754476007933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476007934	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476007935	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
754476007936	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
754476007937	[4Fe-4S] binding site [ion binding]; other site
754476007938	molybdopterin cofactor binding site; other site
754476007939	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
754476007940	molybdopterin cofactor binding site; other site
754476007941	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
754476007942	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
754476007943	[2Fe-2S] cluster binding site [ion binding]; other site
754476007944	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
754476007945	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
754476007946	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
754476007947	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
754476007948	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
754476007949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007951	metal binding site [ion binding]; metal-binding site
754476007952	active site
754476007953	I-site; other site
754476007954	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007955	PAS domain; Region: PAS_9; pfam13426
754476007956	putative active site [active]
754476007957	heme pocket [chemical binding]; other site
754476007958	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007959	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007960	metal binding site [ion binding]; metal-binding site
754476007961	active site
754476007962	I-site; other site
754476007963	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476007964	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
754476007965	MarR family; Region: MarR_2; cl17246
754476007966	PAS domain S-box; Region: sensory_box; TIGR00229
754476007967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007968	putative active site [active]
754476007969	heme pocket [chemical binding]; other site
754476007970	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007971	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007972	metal binding site [ion binding]; metal-binding site
754476007973	active site
754476007974	I-site; other site
754476007975	YcjX-like family, DUF463; Region: DUF463; cl01193
754476007976	hypothetical protein; Provisional; Region: PRK05415
754476007977	Domain of unknown function (DUF697); Region: DUF697; cl12064
754476007978	CHASE domain; Region: CHASE; pfam03924
754476007979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007980	putative active site [active]
754476007981	heme pocket [chemical binding]; other site
754476007982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007983	putative active site [active]
754476007984	PAS fold; Region: PAS_3; pfam08447
754476007985	heme pocket [chemical binding]; other site
754476007986	PAS domain S-box; Region: sensory_box; TIGR00229
754476007987	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476007988	putative active site [active]
754476007989	heme pocket [chemical binding]; other site
754476007990	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476007991	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476007992	metal binding site [ion binding]; metal-binding site
754476007993	active site
754476007994	I-site; other site
754476007995	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
754476007996	putative active site [active]
754476007997	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
754476007998	binding surface
754476007999	TPR motif; other site
754476008000	Tetratricopeptide repeat; Region: TPR_16; pfam13432
754476008001	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476008002	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
754476008003	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
754476008004	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476008005	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
754476008006	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
754476008007	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
754476008008	GIY-YIG motif/motif A; other site
754476008009	active site
754476008010	catalytic site [active]
754476008011	putative DNA binding site [nucleotide binding]; other site
754476008012	metal binding site [ion binding]; metal-binding site
754476008013	UvrB/uvrC motif; Region: UVR; pfam02151
754476008014	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
754476008015	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
754476008016	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
754476008017	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476008018	ATP binding site [chemical binding]; other site
754476008019	putative Mg++ binding site [ion binding]; other site
754476008020	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476008021	nucleotide binding region [chemical binding]; other site
754476008022	ATP-binding site [chemical binding]; other site
754476008023	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
754476008024	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
754476008025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476008026	S-adenosylmethionine binding site [chemical binding]; other site
754476008027	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
754476008028	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
754476008029	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
754476008030	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
754476008031	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
754476008032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
754476008033	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
754476008034	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
754476008035	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
754476008036	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
754476008037	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
754476008038	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
754476008039	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
754476008040	catalytic triad [active]
754476008041	dimer interface [polypeptide binding]; other site
754476008042	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
754476008043	tetramer (dimer of dimers) interface [polypeptide binding]; other site
754476008044	active site
754476008045	dimer interface [polypeptide binding]; other site
754476008046	Phosphotransferase enzyme family; Region: APH; pfam01636
754476008047	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
754476008048	active site
754476008049	ATP binding site [chemical binding]; other site
754476008050	Low molecular weight phosphatase family; Region: LMWPc; cd00115
754476008051	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
754476008052	active site
754476008053	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
754476008054	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
754476008055	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
754476008056	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
754476008057	electron transport complex protein RsxA; Provisional; Region: PRK05151
754476008058	ferredoxin; Provisional; Region: PRK08764
754476008059	Putative Fe-S cluster; Region: FeS; pfam04060
754476008060	4Fe-4S binding domain; Region: Fer4; pfam00037
754476008061	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
754476008062	SLBB domain; Region: SLBB; pfam10531
754476008063	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
754476008064	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
754476008065	FMN-binding domain; Region: FMN_bind; cl01081
754476008066	electron transport complex RsxE subunit; Provisional; Region: PRK12405
754476008067	endonuclease III; Provisional; Region: PRK10702
754476008068	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
754476008069	minor groove reading motif; other site
754476008070	helix-hairpin-helix signature motif; other site
754476008071	substrate binding pocket [chemical binding]; other site
754476008072	active site
754476008073	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
754476008074	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
754476008075	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
754476008076	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
754476008077	putative NAD(P) binding site [chemical binding]; other site
754476008078	dimer interface [polypeptide binding]; other site
754476008079	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
754476008080	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
754476008081	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476008082	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
754476008083	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
754476008084	monovalent cation:proton antiporter; Region: 2a6301s02; TIGR00943
754476008085	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
754476008086	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
754476008087	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476008088	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
754476008089	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
754476008090	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
754476008091	hypothetical protein; Validated; Region: PRK00124
754476008092	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
754476008093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476008094	Major Facilitator Superfamily; Region: MFS_1; pfam07690
754476008095	putative substrate translocation pore; other site
754476008096	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
754476008097	DNA-binding interface [nucleotide binding]; DNA binding site
754476008098	HTH-like domain; Region: HTH_21; pfam13276
754476008099	Integrase core domain; Region: rve; pfam00665
754476008100	Integrase core domain; Region: rve_3; pfam13683
754476008101	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
754476008102	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
754476008103	Predicted ATPase [General function prediction only]; Region: COG3911
754476008104	AAA domain; Region: AAA_28; pfam13521
754476008105	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
754476008106	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
754476008107	Transposase; Region: DEDD_Tnp_IS110; pfam01548
754476008108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
754476008109	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
754476008110	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
754476008111	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
754476008112	Beta-Casp domain; Region: Beta-Casp; smart01027
754476008113	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
754476008114	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
754476008115	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
754476008116	Part of AAA domain; Region: AAA_19; pfam13245
754476008117	Family description; Region: UvrD_C_2; pfam13538
754476008118	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
754476008119	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
754476008120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476008121	Walker A motif; other site
754476008122	ATP binding site [chemical binding]; other site
754476008123	Walker B motif; other site
754476008124	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
754476008125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476008126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476008127	LysR substrate binding domain; Region: LysR_substrate; pfam03466
754476008128	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
754476008129	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
754476008130	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476008131	dimer interface [polypeptide binding]; other site
754476008132	putative CheW interface [polypeptide binding]; other site
754476008133	Protein of unknown function, DUF481; Region: DUF481; cl01213
754476008134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
754476008135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
754476008136	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
754476008137	putative dimerization interface [polypeptide binding]; other site
754476008138	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
754476008139	Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157
754476008140	homodimer interface [polypeptide binding]; other site
754476008141	ligand binding site [chemical binding]; other site
754476008142	NAD binding site [chemical binding]; other site
754476008143	catalytic site [active]
754476008144	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
754476008145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476008146	dimer interface [polypeptide binding]; other site
754476008147	conserved gate region; other site
754476008148	putative PBP binding loops; other site
754476008149	ABC-ATPase subunit interface; other site
754476008150	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
754476008151	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
754476008152	Walker A/P-loop; other site
754476008153	ATP binding site [chemical binding]; other site
754476008154	Q-loop/lid; other site
754476008155	ABC transporter signature motif; other site
754476008156	Walker B; other site
754476008157	D-loop; other site
754476008158	H-loop/switch region; other site
754476008159	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
754476008160	Membrane fusogenic activity; Region: BMFP; pfam04380
754476008161	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
754476008162	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
754476008163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
754476008164	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
754476008165	AAA domain; Region: AAA_30; pfam13604
754476008166	Family description; Region: UvrD_C_2; pfam13538
754476008167	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
754476008168	Part of AAA domain; Region: AAA_19; pfam13245
754476008169	Family description; Region: UvrD_C_2; pfam13538
754476008170	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
754476008171	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
754476008172	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
754476008173	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
754476008174	Radical SAM superfamily; Region: Radical_SAM; pfam04055
754476008175	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476008176	FeS/SAM binding site; other site
754476008177	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
754476008178	HAMP domain; Region: HAMP; pfam00672
754476008179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476008180	dimer interface [polypeptide binding]; other site
754476008181	phosphorylation site [posttranslational modification]
754476008182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476008183	ATP binding site [chemical binding]; other site
754476008184	Mg2+ binding site [ion binding]; other site
754476008185	G-X-G motif; other site
754476008186	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476008187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476008188	active site
754476008189	phosphorylation site [posttranslational modification]
754476008190	intermolecular recognition site; other site
754476008191	dimerization interface [polypeptide binding]; other site
754476008192	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476008193	DNA binding site [nucleotide binding]
754476008194	Outer membrane efflux protein; Region: OEP; pfam02321
754476008195	Outer membrane efflux protein; Region: OEP; pfam02321
754476008196	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
754476008197	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476008198	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
754476008199	K+-transporting ATPase, c chain; Region: KdpC; cl00944
754476008200	Protein of unknown function (DUF3240); Region: DUF3240; pfam11582
754476008201	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
754476008202	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
754476008203	putative active site [active]
754476008204	putative metal binding site [ion binding]; other site
754476008205	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
754476008206	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
754476008207	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
754476008208	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
754476008209	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
754476008210	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
754476008211	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
754476008212	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
754476008213	putative active site [active]
754476008214	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
754476008215	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
754476008216	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
754476008217	phosphoribulokinase; Provisional; Region: PRK15453
754476008218	active site
754476008219	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
754476008220	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
754476008221	intersubunit interface [polypeptide binding]; other site
754476008222	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
754476008223	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
754476008224	putative active site [active]
754476008225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
754476008226	LabA_like proteins; Region: LabA_like/DUF88; cl10034
754476008227	putative metal binding site [ion binding]; other site
754476008228	Uncharacterized conserved protein [Function unknown]; Region: COG1432
754476008229	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
754476008230	putative metal binding site [ion binding]; other site
754476008231	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
754476008232	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
754476008233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
754476008234	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
754476008235	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
754476008236	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476008237	non-specific DNA binding site [nucleotide binding]; other site
754476008238	salt bridge; other site
754476008239	sequence-specific DNA binding site [nucleotide binding]; other site
754476008240	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
754476008241	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
754476008242	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
754476008243	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
754476008244	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
754476008245	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476008246	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
754476008247	PRC-barrel domain; Region: PRC; pfam05239
754476008248	Repair protein; Region: Repair_PSII; pfam04536
754476008249	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
754476008250	protein binding site [polypeptide binding]; other site
754476008251	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
754476008252	LemA family; Region: LemA; cl00742
754476008253	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
754476008254	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
754476008255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476008256	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
754476008257	Coenzyme A binding pocket [chemical binding]; other site
754476008258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476008259	Coenzyme A binding pocket [chemical binding]; other site
754476008260	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
754476008261	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
754476008262	active site
754476008263	catalytic tetrad [active]
754476008264	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
754476008265	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
754476008266	DNA methylase; Region: N6_N4_Mtase; pfam01555
754476008267	Fic family protein [Function unknown]; Region: COG3177
754476008268	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
754476008269	Fic/DOC family; Region: Fic; pfam02661
754476008270	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
754476008271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
754476008272	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
754476008273	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
754476008274	dimerization interface [polypeptide binding]; other site
754476008275	domain crossover interface; other site
754476008276	redox-dependent activation switch; other site
754476008277	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476008278	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476008279	Fic family protein [Function unknown]; Region: COG3177
754476008280	Fic/DOC family; Region: Fic; pfam02661
754476008281	heat shock protein 90; Provisional; Region: PRK05218
754476008282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476008283	ATP binding site [chemical binding]; other site
754476008284	Mg2+ binding site [ion binding]; other site
754476008285	G-X-G motif; other site
754476008286	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
754476008287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476008288	dimerization interface [polypeptide binding]; other site
754476008289	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476008290	dimer interface [polypeptide binding]; other site
754476008291	putative CheW interface [polypeptide binding]; other site
754476008292	PAS domain; Region: PAS_9; pfam13426
754476008293	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476008294	putative active site [active]
754476008295	heme pocket [chemical binding]; other site
754476008296	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476008297	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476008298	metal binding site [ion binding]; metal-binding site
754476008299	active site
754476008300	I-site; other site
754476008301	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476008302	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
754476008303	putative catalytic site [active]
754476008304	putative metal binding site [ion binding]; other site
754476008305	putative phosphate binding site [ion binding]; other site
754476008306	Domain of unknown function (DUF897); Region: DUF897; cl01312
754476008307	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
754476008308	Protein of unknown function (DUF421); Region: DUF421; pfam04239
754476008309	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
754476008310	DNA-binding site [nucleotide binding]; DNA binding site
754476008311	RNA-binding motif; other site
754476008312	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
754476008313	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
754476008314	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
754476008315	catalytic triad [active]
754476008316	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
754476008317	SnoaL-like domain; Region: SnoaL_3; pfam13474
754476008318	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
754476008319	putative active site pocket [active]
754476008320	dimerization interface [polypeptide binding]; other site
754476008321	putative catalytic residue [active]
754476008322	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
754476008323	active site
754476008324	HIGH motif; other site
754476008325	nucleotide binding site [chemical binding]; other site
754476008326	active site
754476008327	KMSKS motif; other site
754476008328	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
754476008329	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476008330	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476008331	metal binding site [ion binding]; metal-binding site
754476008332	active site
754476008333	I-site; other site
754476008334	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
754476008335	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
754476008336	metal-binding site [ion binding]
754476008337	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
754476008338	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476008339	motif II; other site
754476008340	Predicted amidohydrolase [General function prediction only]; Region: COG0388
754476008341	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
754476008342	putative active site [active]
754476008343	catalytic triad [active]
754476008344	putative dimer interface [polypeptide binding]; other site
754476008345	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
754476008346	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
754476008347	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
754476008348	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
754476008349	DNA-binding site [nucleotide binding]; DNA binding site
754476008350	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
754476008351	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476008352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476008353	homodimer interface [polypeptide binding]; other site
754476008354	catalytic residue [active]
754476008355	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
754476008356	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476008357	substrate binding pocket [chemical binding]; other site
754476008358	membrane-bound complex binding site; other site
754476008359	hinge residues; other site
754476008360	PAS fold; Region: PAS_4; pfam08448
754476008361	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476008362	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476008363	metal binding site [ion binding]; metal-binding site
754476008364	active site
754476008365	I-site; other site
754476008366	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476008367	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
754476008368	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
754476008369	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
754476008370	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
754476008371	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
754476008372	substrate binding pocket [chemical binding]; other site
754476008373	membrane-bound complex binding site; other site
754476008374	hinge residues; other site
754476008375	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476008376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476008377	metal binding site [ion binding]; metal-binding site
754476008378	active site
754476008379	I-site; other site
754476008380	hypothetical protein; Validated; Region: PRK02101
754476008381	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
754476008382	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
754476008383	DctM-like transporters; Region: DctM; pfam06808
754476008384	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
754476008385	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
754476008386	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
754476008387	motif 1; other site
754476008388	dimer interface [polypeptide binding]; other site
754476008389	active site
754476008390	motif 2; other site
754476008391	motif 3; other site
754476008392	elongation factor P; Validated; Region: PRK00529
754476008393	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
754476008394	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
754476008395	RNA binding site [nucleotide binding]; other site
754476008396	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
754476008397	RNA binding site [nucleotide binding]; other site
754476008398	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476008399	Radical SAM superfamily; Region: Radical_SAM; pfam04055
754476008400	FeS/SAM binding site; other site
754476008401	citrate synthase; Provisional; Region: PRK14036
754476008402	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
754476008403	oxalacetate binding site [chemical binding]; other site
754476008404	citrylCoA binding site [chemical binding]; other site
754476008405	coenzyme A binding site [chemical binding]; other site
754476008406	catalytic triad [active]
754476008407	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
754476008408	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
754476008409	lipoyl synthase; Provisional; Region: PRK05481
754476008410	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476008411	FeS/SAM binding site; other site
754476008412	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
754476008413	Protein of unknown function (DUF493); Region: DUF493; pfam04359
754476008414	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
754476008415	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
754476008416	homodimer interface [polypeptide binding]; other site
754476008417	substrate-cofactor binding pocket; other site
754476008418	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476008419	catalytic residue [active]
754476008420	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
754476008421	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
754476008422	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
754476008423	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
754476008424	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
754476008425	Sporulation related domain; Region: SPOR; pfam05036
754476008426	Transglycosylase SLT domain; Region: SLT_2; pfam13406
754476008427	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
754476008428	N-acetyl-D-glucosamine binding site [chemical binding]; other site
754476008429	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
754476008430	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
754476008431	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
754476008432	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
754476008433	rod shape-determining protein MreD; Region: MreD; cl01087
754476008434	rod shape-determining protein MreC; Provisional; Region: PRK13922
754476008435	rod shape-determining protein MreC; Region: MreC; pfam04085
754476008436	rod shape-determining protein MreB; Provisional; Region: PRK13927
754476008437	MreB and similar proteins; Region: MreB_like; cd10225
754476008438	nucleotide binding site [chemical binding]; other site
754476008439	Mg binding site [ion binding]; other site
754476008440	putative protofilament interaction site [polypeptide binding]; other site
754476008441	RodZ interaction site [polypeptide binding]; other site
754476008442	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
754476008443	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
754476008444	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
754476008445	acetolactate synthase; Reviewed; Region: PRK08322
754476008446	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
754476008447	PYR/PP interface [polypeptide binding]; other site
754476008448	dimer interface [polypeptide binding]; other site
754476008449	TPP binding site [chemical binding]; other site
754476008450	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
754476008451	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
754476008452	TPP-binding site [chemical binding]; other site
754476008453	dimer interface [polypeptide binding]; other site
754476008454	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
754476008455	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
754476008456	catalytic residues [active]
754476008457	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
754476008458	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
754476008459	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
754476008460	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
754476008461	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
754476008462	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
754476008463	Walker A/P-loop; other site
754476008464	ATP binding site [chemical binding]; other site
754476008465	Q-loop/lid; other site
754476008466	ABC transporter signature motif; other site
754476008467	Walker B; other site
754476008468	D-loop; other site
754476008469	H-loop/switch region; other site
754476008470	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
754476008471	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
754476008472	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
754476008473	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
754476008474	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
754476008475	DNA binding site [nucleotide binding]
754476008476	catalytic residue [active]
754476008477	H2TH interface [polypeptide binding]; other site
754476008478	putative catalytic residues [active]
754476008479	turnover-facilitating residue; other site
754476008480	intercalation triad [nucleotide binding]; other site
754476008481	8OG recognition residue [nucleotide binding]; other site
754476008482	putative reading head residues; other site
754476008483	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
754476008484	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
754476008485	Cytochrome c; Region: Cytochrom_C; cl11414
754476008486	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
754476008487	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476008488	RNA binding surface [nucleotide binding]; other site
754476008489	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
754476008490	active site
754476008491	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
754476008492	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
754476008493	Chromate transporter; Region: Chromate_transp; pfam02417
754476008494	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
754476008495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476008496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476008497	DNA binding residues [nucleotide binding]
754476008498	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
754476008499	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
754476008500	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476008501	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
754476008502	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
754476008503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
754476008504	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
754476008505	heme binding pocket [chemical binding]; other site
754476008506	heme ligand [chemical binding]; other site
754476008507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
754476008508	Tetratricopeptide repeat; Region: TPR_10; cl17452
754476008509	Tetratricopeptide repeat; Region: TPR_12; pfam13424
754476008510	TPR repeat; Region: TPR_11; pfam13414
754476008511	Protein of unknown function (DUF560); Region: DUF560; pfam04575
754476008512	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
754476008513	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
754476008514	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
754476008515	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
754476008516	FecR protein; Region: FecR; pfam04773
754476008517	elongation factor G; Reviewed; Region: PRK00007
754476008518	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
754476008519	G2 box; other site
754476008520	Switch I region; other site
754476008521	G3 box; other site
754476008522	Switch II region; other site
754476008523	GTP/Mg2+ binding site [chemical binding]; other site
754476008524	G4 box; other site
754476008525	G5 box; other site
754476008526	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
754476008527	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
754476008528	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
754476008529	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
754476008530	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
754476008531	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476008532	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
754476008533	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476008534	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
754476008535	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
754476008536	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
754476008537	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
754476008538	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
754476008539	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
754476008540	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
754476008541	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
754476008542	4Fe-4S binding domain; Region: Fer4; pfam00037
754476008543	4Fe-4S binding domain; Region: Fer4; pfam00037
754476008544	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
754476008545	NADH dehydrogenase subunit G; Validated; Region: PRK09129
754476008546	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
754476008547	catalytic loop [active]
754476008548	iron binding site [ion binding]; other site
754476008549	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
754476008550	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
754476008551	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
754476008552	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
754476008553	SLBB domain; Region: SLBB; pfam10531
754476008554	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
754476008555	NADH dehydrogenase subunit E; Validated; Region: PRK07539
754476008556	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
754476008557	putative dimer interface [polypeptide binding]; other site
754476008558	[2Fe-2S] cluster binding site [ion binding]; other site
754476008559	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
754476008560	NADH dehydrogenase subunit D; Validated; Region: PRK06075
754476008561	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
754476008562	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
754476008563	NADH dehydrogenase subunit B; Validated; Region: PRK06411
754476008564	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
754476008565	Predicted permeases [General function prediction only]; Region: RarD; COG2962
754476008566	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
754476008567	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
754476008568	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
754476008569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
754476008570	non-specific DNA binding site [nucleotide binding]; other site
754476008571	salt bridge; other site
754476008572	sequence-specific DNA binding site [nucleotide binding]; other site
754476008573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
754476008574	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
754476008575	putative active site [active]
754476008576	heme pocket [chemical binding]; other site
754476008577	Integrase core domain; Region: rve_3; pfam13683
754476008578	integrase; Provisional; Region: PRK09692
754476008579	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
754476008580	active site
754476008581	Int/Topo IB signature motif; other site
754476008582	Preprotein translocase SecG subunit; Region: SecG; cl09123
754476008583	triosephosphate isomerase; Provisional; Region: PRK14567
754476008584	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
754476008585	substrate binding site [chemical binding]; other site
754476008586	dimer interface [polypeptide binding]; other site
754476008587	catalytic triad [active]
754476008588	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
754476008589	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
754476008590	active site
754476008591	substrate binding site [chemical binding]; other site
754476008592	metal binding site [ion binding]; metal-binding site
754476008593	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
754476008594	dihydropteroate synthase; Region: DHPS; TIGR01496
754476008595	substrate binding pocket [chemical binding]; other site
754476008596	dimer interface [polypeptide binding]; other site
754476008597	inhibitor binding site; inhibition site
754476008598	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
754476008599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476008600	Walker A motif; other site
754476008601	ATP binding site [chemical binding]; other site
754476008602	Walker B motif; other site
754476008603	arginine finger; other site
754476008604	Peptidase family M41; Region: Peptidase_M41; pfam01434
754476008605	FtsJ-like methyltransferase; Region: FtsJ; cl17430
754476008606	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
754476008607	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
754476008608	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
754476008609	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
754476008610	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
754476008611	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
754476008612	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
754476008613	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
754476008614	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
754476008615	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
754476008616	ATP-grasp domain; Region: ATP-grasp_4; cl17255
754476008617	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
754476008618	IMP binding site; other site
754476008619	dimer interface [polypeptide binding]; other site
754476008620	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
754476008621	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
754476008622	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
754476008623	catalytic site [active]
754476008624	subunit interface [polypeptide binding]; other site
754476008625	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
754476008626	dimer interface [polypeptide binding]; other site
754476008627	allosteric magnesium binding site [ion binding]; other site
754476008628	active site
754476008629	aspartate-rich active site metal binding site; other site
754476008630	Schiff base residues; other site
754476008631	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
754476008632	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
754476008633	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
754476008634	shikimate binding site; other site
754476008635	NAD(P) binding site [chemical binding]; other site
754476008636	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
754476008637	dimer interface [polypeptide binding]; other site
754476008638	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
754476008639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476008640	active site
754476008641	phosphorylation site [posttranslational modification]
754476008642	intermolecular recognition site; other site
754476008643	dimerization interface [polypeptide binding]; other site
754476008644	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
754476008645	DNA binding site [nucleotide binding]
754476008646	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
754476008647	dimerization interface [polypeptide binding]; other site
754476008648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
754476008649	dimer interface [polypeptide binding]; other site
754476008650	phosphorylation site [posttranslational modification]
754476008651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476008652	ATP binding site [chemical binding]; other site
754476008653	Mg2+ binding site [ion binding]; other site
754476008654	G-X-G motif; other site
754476008655	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
754476008656	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
754476008657	E-class dimer interface [polypeptide binding]; other site
754476008658	P-class dimer interface [polypeptide binding]; other site
754476008659	active site
754476008660	Cu2+ binding site [ion binding]; other site
754476008661	Zn2+ binding site [ion binding]; other site
754476008662	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
754476008663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
754476008664	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
754476008665	HlyD family secretion protein; Region: HlyD_3; pfam13437
754476008666	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
754476008667	MarR family; Region: MarR_2; cl17246
754476008668	Cell division protein ZapA; Region: ZapA; pfam05164
754476008669	TIGR02449 family protein; Region: TIGR02449
754476008670	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
754476008671	proline aminopeptidase P II; Provisional; Region: PRK10879
754476008672	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
754476008673	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
754476008674	active site
754476008675	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
754476008676	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
754476008677	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
754476008678	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
754476008679	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
754476008680	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
754476008681	ATP binding site [chemical binding]; other site
754476008682	Mg++ binding site [ion binding]; other site
754476008683	motif III; other site
754476008684	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476008685	nucleotide binding region [chemical binding]; other site
754476008686	ATP-binding site [chemical binding]; other site
754476008687	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
754476008688	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
754476008689	catalytic residues [active]
754476008690	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
754476008691	Part of AAA domain; Region: AAA_19; pfam13245
754476008692	Family description; Region: UvrD_C_2; pfam13538
754476008693	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
754476008694	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
754476008695	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
754476008696	Predicted metal-binding protein [General function prediction only]; Region: COG3019
754476008697	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
754476008698	EamA-like transporter family; Region: EamA; cl17759
754476008699	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
754476008700	DEAD-like helicases superfamily; Region: DEXDc; smart00487
754476008701	ATP binding site [chemical binding]; other site
754476008702	putative Mg++ binding site [ion binding]; other site
754476008703	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
754476008704	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
754476008705	glycogen synthase; Provisional; Region: glgA; PRK00654
754476008706	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
754476008707	ADP-binding pocket [chemical binding]; other site
754476008708	homodimer interface [polypeptide binding]; other site
754476008709	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
754476008710	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
754476008711	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
754476008712	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
754476008713	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
754476008714	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
754476008715	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
754476008716	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
754476008717	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
754476008718	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
754476008719	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
754476008720	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
754476008721	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
754476008722	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
754476008723	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
754476008724	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
754476008725	FHIPEP family; Region: FHIPEP; pfam00771
754476008726	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
754476008727	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
754476008728	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
754476008729	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
754476008730	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
754476008731	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
754476008732	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
754476008733	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
754476008734	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
754476008735	DNA binding residues [nucleotide binding]
754476008736	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
754476008737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476008738	active site
754476008739	phosphorylation site [posttranslational modification]
754476008740	intermolecular recognition site; other site
754476008741	dimerization interface [polypeptide binding]; other site
754476008742	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
754476008743	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
754476008744	putative binding surface; other site
754476008745	active site
754476008746	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
754476008747	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
754476008748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
754476008749	ATP binding site [chemical binding]; other site
754476008750	Mg2+ binding site [ion binding]; other site
754476008751	G-X-G motif; other site
754476008752	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
754476008753	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
754476008754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
754476008755	active site
754476008756	phosphorylation site [posttranslational modification]
754476008757	intermolecular recognition site; other site
754476008758	dimerization interface [polypeptide binding]; other site
754476008759	CheB methylesterase; Region: CheB_methylest; pfam01339
754476008760	flagellar motor protein; Reviewed; Region: motC; PRK09109
754476008761	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
754476008762	flagellar motor protein MotD; Reviewed; Region: PRK09038
754476008763	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
754476008764	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
754476008765	ligand binding site [chemical binding]; other site
754476008766	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
754476008767	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476008768	P-loop; other site
754476008769	Magnesium ion binding site [ion binding]; other site
754476008770	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
754476008771	Magnesium ion binding site [ion binding]; other site
754476008772	CheW-like domain; Region: CheW; pfam01584
754476008773	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
754476008774	putative CheA interaction surface; other site
754476008775	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
754476008776	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
754476008777	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
754476008778	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
754476008779	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476008780	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
754476008781	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
754476008782	Glucokinase; Region: Glucokinase; pfam02685
754476008783	glucokinase, proteobacterial type; Region: glk; TIGR00749
754476008784	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
754476008785	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
754476008786	putative active site [active]
754476008787	Uncharacterized conserved protein [Function unknown]; Region: COG2968
754476008788	Protein of unknown function (DUF541); Region: SIMPL; cl01077
754476008789	threonine dehydratase; Reviewed; Region: PRK09224
754476008790	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
754476008791	tetramer interface [polypeptide binding]; other site
754476008792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476008793	catalytic residue [active]
754476008794	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
754476008795	putative Ile/Val binding site [chemical binding]; other site
754476008796	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
754476008797	putative Ile/Val binding site [chemical binding]; other site
754476008798	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
754476008799	tetramer (dimer of dimers) interface [polypeptide binding]; other site
754476008800	active site
754476008801	dimer interface [polypeptide binding]; other site
754476008802	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
754476008803	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
754476008804	FtsX-like permease family; Region: FtsX; pfam02687
754476008805	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
754476008806	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
754476008807	Walker A/P-loop; other site
754476008808	ATP binding site [chemical binding]; other site
754476008809	Q-loop/lid; other site
754476008810	ABC transporter signature motif; other site
754476008811	Walker B; other site
754476008812	D-loop; other site
754476008813	H-loop/switch region; other site
754476008814	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
754476008815	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
754476008816	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
754476008817	Competence protein; Region: Competence; pfam03772
754476008818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
754476008819	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
754476008820	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
754476008821	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
754476008822	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
754476008823	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
754476008824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476008825	Walker A/P-loop; other site
754476008826	ATP binding site [chemical binding]; other site
754476008827	Q-loop/lid; other site
754476008828	ABC transporter signature motif; other site
754476008829	Walker B; other site
754476008830	D-loop; other site
754476008831	H-loop/switch region; other site
754476008832	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
754476008833	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
754476008834	Uncharacterized conserved protein [Function unknown]; Region: COG2835
754476008835	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
754476008836	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
754476008837	Ligand binding site; other site
754476008838	oligomer interface; other site
754476008839	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
754476008840	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
754476008841	homodimer interface [polypeptide binding]; other site
754476008842	oligonucleotide binding site [chemical binding]; other site
754476008843	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
754476008844	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
754476008845	RNA binding surface [nucleotide binding]; other site
754476008846	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
754476008847	active site
754476008848	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
754476008849	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
754476008850	motif II; other site
754476008851	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
754476008852	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
754476008853	tandem repeat interface [polypeptide binding]; other site
754476008854	oligomer interface [polypeptide binding]; other site
754476008855	active site residues [active]
754476008856	HDOD domain; Region: HDOD; pfam08668
754476008857	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476008858	Zn2+ binding site [ion binding]; other site
754476008859	Mg2+ binding site [ion binding]; other site
754476008860	adenylate kinase; Reviewed; Region: adk; PRK00279
754476008861	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
754476008862	AMP-binding site [chemical binding]; other site
754476008863	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
754476008864	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
754476008865	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
754476008866	substrate binding site [chemical binding]; other site
754476008867	ATP binding site [chemical binding]; other site
754476008868	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
754476008869	iron-sulfur cluster [ion binding]; other site
754476008870	[2Fe-2S] cluster binding site [ion binding]; other site
754476008871	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
754476008872	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
754476008873	Helicase; Region: Helicase_RecD; pfam05127
754476008874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
754476008875	Coenzyme A binding pocket [chemical binding]; other site
754476008876	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
754476008877	SlyX; Region: SlyX; pfam04102
754476008878	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
754476008879	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
754476008880	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
754476008881	substrate binding pocket [chemical binding]; other site
754476008882	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
754476008883	B12 binding site [chemical binding]; other site
754476008884	cobalt ligand [ion binding]; other site
754476008885	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
754476008886	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
754476008887	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
754476008888	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
754476008889	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
754476008890	dimer interface [polypeptide binding]; other site
754476008891	active site residues [active]
754476008892	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
754476008893	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
754476008894	Cytochrome P450; Region: p450; cl12078
754476008895	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
754476008896	dinuclear metal binding motif [ion binding]; other site
754476008897	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
754476008898	dimerization interface [polypeptide binding]; other site
754476008899	FOG: CBS domain [General function prediction only]; Region: COG0517
754476008900	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
754476008901	short chain dehydrogenase; Provisional; Region: PRK06701
754476008902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476008903	NAD(P) binding site [chemical binding]; other site
754476008904	active site
754476008905	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
754476008906	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
754476008907	dimer interface [polypeptide binding]; other site
754476008908	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
754476008909	putative CheW interface [polypeptide binding]; other site
754476008910	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
754476008911	2-isopropylmalate synthase; Validated; Region: PRK03739
754476008912	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
754476008913	active site
754476008914	catalytic residues [active]
754476008915	metal binding site [ion binding]; metal-binding site
754476008916	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
754476008917	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
754476008918	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
754476008919	putative DNA binding site [nucleotide binding]; other site
754476008920	putative Zn2+ binding site [ion binding]; other site
754476008921	AsnC family; Region: AsnC_trans_reg; pfam01037
754476008922	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
754476008923	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
754476008924	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
754476008925	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
754476008926	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
754476008927	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
754476008928	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
754476008929	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
754476008930	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
754476008931	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
754476008932	Sodium Bile acid symporter family; Region: SBF; cl17470
754476008933	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
754476008934	Mechanosensitive ion channel; Region: MS_channel; pfam00924
754476008935	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
754476008936	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
754476008937	putative active site [active]
754476008938	PhoH-like protein; Region: PhoH; pfam02562
754476008939	PilZ domain; Region: PilZ; pfam07238
754476008940	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
754476008941	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
754476008942	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
754476008943	putative N-terminal domain interface [polypeptide binding]; other site
754476008944	putative dimer interface [polypeptide binding]; other site
754476008945	putative substrate binding pocket (H-site) [chemical binding]; other site
754476008946	AAA domain; Region: AAA_26; pfam13500
754476008947	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
754476008948	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
754476008949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
754476008950	S-adenosylmethionine binding site [chemical binding]; other site
754476008951	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
754476008952	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
754476008953	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
754476008954	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
754476008955	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
754476008956	catalytic residue [active]
754476008957	biotin synthase; Provisional; Region: PRK15108
754476008958	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476008959	FeS/SAM binding site; other site
754476008960	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
754476008961	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
754476008962	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
754476008963	active site
754476008964	Protein of unknown function, DUF484; Region: DUF484; cl17449
754476008965	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
754476008966	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
754476008967	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
754476008968	metal binding site [ion binding]; metal-binding site
754476008969	active site
754476008970	I-site; other site
754476008971	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
754476008972	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
754476008973	FOG: CBS domain [General function prediction only]; Region: COG0517
754476008974	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
754476008975	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
754476008976	Catalytic site; other site
754476008977	Staphylococcal nuclease homologue; Region: SNase; pfam00565
754476008978	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
754476008979	UbiA prenyltransferase family; Region: UbiA; pfam01040
754476008980	Chorismate lyase; Region: Chor_lyase; cl01230
754476008981	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
754476008982	Y-family of DNA polymerases; Region: PolY; cl12025
754476008983	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
754476008984	ssDNA binding site; other site
754476008985	generic binding surface II; other site
754476008986	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476008987	ATP binding site [chemical binding]; other site
754476008988	putative Mg++ binding site [ion binding]; other site
754476008989	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
754476008990	nucleotide binding region [chemical binding]; other site
754476008991	ATP-binding site [chemical binding]; other site
754476008992	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
754476008993	homotrimer interaction site [polypeptide binding]; other site
754476008994	putative active site [active]
754476008995	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
754476008996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476008997	Zn2+ binding site [ion binding]; other site
754476008998	Mg2+ binding site [ion binding]; other site
754476008999	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
754476009000	synthetase active site [active]
754476009001	NTP binding site [chemical binding]; other site
754476009002	metal binding site [ion binding]; metal-binding site
754476009003	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
754476009004	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
754476009005	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
754476009006	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
754476009007	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
754476009008	catalytic site [active]
754476009009	G-X2-G-X-G-K; other site
754476009010	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
754476009011	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
754476009012	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
754476009013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
754476009014	dimer interface [polypeptide binding]; other site
754476009015	conserved gate region; other site
754476009016	putative PBP binding loops; other site
754476009017	ABC-ATPase subunit interface; other site
754476009018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
754476009019	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
754476009020	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
754476009021	Walker A/P-loop; other site
754476009022	ATP binding site [chemical binding]; other site
754476009023	Q-loop/lid; other site
754476009024	ABC transporter signature motif; other site
754476009025	Walker B; other site
754476009026	D-loop; other site
754476009027	H-loop/switch region; other site
754476009028	TOBE domain; Region: TOBE_2; pfam08402
754476009029	regulatory protein CsrD; Provisional; Region: PRK11059
754476009030	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
754476009031	DEAD-like helicases superfamily; Region: DEXDc; smart00487
754476009032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
754476009033	ATP binding site [chemical binding]; other site
754476009034	putative Mg++ binding site [ion binding]; other site
754476009035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
754476009036	nucleotide binding region [chemical binding]; other site
754476009037	ATP-binding site [chemical binding]; other site
754476009038	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
754476009039	SEC-C motif; Region: SEC-C; pfam02810
754476009040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
754476009041	Walker A motif; other site
754476009042	ATP binding site [chemical binding]; other site
754476009043	Walker B motif; other site
754476009044	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
754476009045	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
754476009046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476009047	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476009048	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476009049	hypothetical protein; Provisional; Region: PRK11820
754476009050	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
754476009051	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
754476009052	ribonuclease PH; Reviewed; Region: rph; PRK00173
754476009053	Ribonuclease PH; Region: RNase_PH_bact; cd11362
754476009054	hexamer interface [polypeptide binding]; other site
754476009055	active site
754476009056	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
754476009057	active site
754476009058	dimerization interface [polypeptide binding]; other site
754476009059	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
754476009060	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
754476009061	FeS/SAM binding site; other site
754476009062	HemN C-terminal domain; Region: HemN_C; pfam06969
754476009063	threonine synthase; Reviewed; Region: PRK06721
754476009064	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
754476009065	homodimer interface [polypeptide binding]; other site
754476009066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476009067	catalytic residue [active]
754476009068	homoserine dehydrogenase; Provisional; Region: PRK06349
754476009069	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
754476009070	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
754476009071	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
754476009072	aminotransferase; Validated; Region: PRK08175
754476009073	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
754476009074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
754476009075	homodimer interface [polypeptide binding]; other site
754476009076	catalytic residue [active]
754476009077	HDOD domain; Region: HDOD; pfam08668
754476009078	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
754476009079	active site
754476009080	DNA binding site [nucleotide binding]
754476009081	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
754476009082	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
754476009083	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
754476009084	active site
754476009085	FMN binding site [chemical binding]; other site
754476009086	substrate binding site [chemical binding]; other site
754476009087	homotetramer interface [polypeptide binding]; other site
754476009088	catalytic residue [active]
754476009089	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
754476009090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
754476009091	NAD(P) binding site [chemical binding]; other site
754476009092	active site
754476009093	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
754476009094	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
754476009095	catalytic residues [active]
754476009096	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
754476009097	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
754476009098	dimerization domain [polypeptide binding]; other site
754476009099	dimer interface [polypeptide binding]; other site
754476009100	catalytic residues [active]
754476009101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
754476009102	putative substrate translocation pore; other site
754476009103	HI0933-like protein; Region: HI0933_like; pfam03486
754476009104	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
754476009105	active site
754476009106	ATP binding site [chemical binding]; other site
754476009107	substrate binding site [chemical binding]; other site
754476009108	activation loop (A-loop); other site
754476009109	Phospholipid methyltransferase; Region: PEMT; cl17370
754476009110	NlpC/P60 family; Region: NLPC_P60; pfam00877
754476009111	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
754476009112	Methyltransferase domain; Region: Methyltransf_18; pfam12847
754476009113	Erythromycin esterase; Region: Erythro_esteras; pfam05139
754476009114	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
754476009115	MAPEG family; Region: MAPEG; pfam01124
754476009116	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
754476009117	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
754476009118	trimer interface [polypeptide binding]; other site
754476009119	putative metal binding site [ion binding]; other site
754476009120	HDOD domain; Region: HDOD; pfam08668
754476009121	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
754476009122	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
754476009123	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
754476009124	Zn2+ binding site [ion binding]; other site
754476009125	Mg2+ binding site [ion binding]; other site
754476009126	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476009127	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476009128	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
754476009129	ABC-2 type transporter; Region: ABC2_membrane; cl17235
754476009130	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
754476009131	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
754476009132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
754476009133	Walker A/P-loop; other site
754476009134	ATP binding site [chemical binding]; other site
754476009135	Q-loop/lid; other site
754476009136	ABC transporter signature motif; other site
754476009137	Walker B; other site
754476009138	D-loop; other site
754476009139	H-loop/switch region; other site
754476009140	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476009141	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476009142	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
754476009143	amino acid transporter; Region: 2A0306; TIGR00909
754476009144	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
754476009145	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
754476009146	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
754476009147	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
754476009148	active site
754476009149	substrate binding site [chemical binding]; other site
754476009150	Phosphotransferase enzyme family; Region: APH; pfam01636
754476009151	ATP binding site [chemical binding]; other site
754476009152	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
754476009153	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
754476009154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476009155	HTH-like domain; Region: HTH_21; pfam13276
754476009156	Integrase core domain; Region: rve; pfam00665
754476009157	Transposase; Region: HTH_Tnp_1; cl17663
754476009158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
754476009159	putative protease; Provisional; Region: PRK15452
754476009160	Peptidase family U32; Region: Peptidase_U32; pfam01136
754476009161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
754476009162	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
754476009163	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340