-- dump date 20140619_145521 -- class Genbank::misc_feature -- table misc_feature_note -- id note 856793000001 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 856793000002 substrate binding site [chemical binding]; other site 856793000003 active site 856793000004 ferrochelatase; Reviewed; Region: hemH; PRK00035 856793000005 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 856793000006 C-terminal domain interface [polypeptide binding]; other site 856793000007 active site 856793000008 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 856793000009 active site 856793000010 N-terminal domain interface [polypeptide binding]; other site 856793000011 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 856793000012 transcription termination factor Rho; Provisional; Region: rho; PRK09376 856793000013 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 856793000014 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 856793000015 RNA binding site [nucleotide binding]; other site 856793000016 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 856793000017 multimer interface [polypeptide binding]; other site 856793000018 Walker A motif; other site 856793000019 ATP binding site [chemical binding]; other site 856793000020 Walker B motif; other site 856793000021 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 856793000022 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 856793000023 Zn binding sites [ion binding]; other site 856793000024 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 856793000025 Dienelactone hydrolase family; Region: DLH; pfam01738 856793000026 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 856793000027 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 856793000028 trmE is a tRNA modification GTPase; Region: trmE; cd04164 856793000029 G1 box; other site 856793000030 GTP/Mg2+ binding site [chemical binding]; other site 856793000031 Switch I region; other site 856793000032 G2 box; other site 856793000033 Switch II region; other site 856793000034 G3 box; other site 856793000035 G4 box; other site 856793000036 G5 box; other site 856793000037 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 856793000038 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 856793000039 Mechanosensitive ion channel; Region: MS_channel; pfam00924 856793000040 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 856793000041 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 856793000042 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 856793000043 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 856793000044 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 856793000045 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 856793000046 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 856793000047 P-loop; other site 856793000048 Magnesium ion binding site [ion binding]; other site 856793000049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 856793000050 Magnesium ion binding site [ion binding]; other site 856793000051 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 856793000052 ParB-like nuclease domain; Region: ParB; smart00470 856793000053 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 856793000054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 856793000055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 856793000056 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 856793000057 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 856793000058 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 856793000059 Zn binding site [ion binding]; other site 856793000060 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 856793000061 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 856793000062 HIGH motif; other site 856793000063 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 856793000064 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793000065 active site 856793000066 KMSKS motif; other site 856793000067 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 856793000068 tRNA binding surface [nucleotide binding]; other site 856793000069 Lipopolysaccharide-assembly; Region: LptE; cl01125 856793000070 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 856793000071 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 856793000072 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 856793000073 Gram-negative porin; Region: Porin_4; pfam13609 856793000074 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 856793000075 Gram-negative porin; Region: Porin_4; pfam13609 856793000076 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 856793000077 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 856793000078 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 856793000079 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 856793000080 catalytic residue [active] 856793000081 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793000082 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 856793000083 DNA binding site [nucleotide binding] 856793000084 Smr domain; Region: Smr; pfam01713 856793000085 Peptidase family M23; Region: Peptidase_M23; pfam01551 856793000086 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 856793000087 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 856793000088 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 856793000089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 856793000090 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 856793000091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793000092 Coenzyme A binding pocket [chemical binding]; other site 856793000093 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 856793000094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793000095 Coenzyme A binding pocket [chemical binding]; other site 856793000096 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 856793000097 nucleotide binding site/active site [active] 856793000098 HIT family signature motif; other site 856793000099 catalytic residue [active] 856793000100 MASE1; Region: MASE1; pfam05231 856793000101 CHASE domain; Region: CHASE; pfam03924 856793000102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793000103 dimer interface [polypeptide binding]; other site 856793000104 phosphorylation site [posttranslational modification] 856793000105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793000106 ATP binding site [chemical binding]; other site 856793000107 Mg2+ binding site [ion binding]; other site 856793000108 G-X-G motif; other site 856793000109 Response regulator receiver domain; Region: Response_reg; pfam00072 856793000110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000111 active site 856793000112 phosphorylation site [posttranslational modification] 856793000113 intermolecular recognition site; other site 856793000114 dimerization interface [polypeptide binding]; other site 856793000115 Hpt domain; Region: Hpt; pfam01627 856793000116 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 856793000117 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 856793000118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793000119 Walker A motif; other site 856793000120 ATP binding site [chemical binding]; other site 856793000121 Walker B motif; other site 856793000122 arginine finger; other site 856793000123 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 856793000124 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 856793000125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 856793000126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793000127 metal binding site [ion binding]; metal-binding site 856793000128 active site 856793000129 I-site; other site 856793000130 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000131 FOG: WD40 repeat [General function prediction only]; Region: COG2319 856793000132 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000133 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000134 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000135 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000136 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000137 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 856793000138 Part of AAA domain; Region: AAA_19; pfam13245 856793000139 Family description; Region: UvrD_C_2; pfam13538 856793000140 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 856793000141 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 856793000142 putative NAD(P) binding site [chemical binding]; other site 856793000143 active site 856793000144 SurA N-terminal domain; Region: SurA_N; pfam09312 856793000145 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 856793000146 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 856793000147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793000148 S-adenosylmethionine binding site [chemical binding]; other site 856793000149 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 856793000150 cytidylate kinase, putative; Region: cyt_kin_arch; TIGR02173 856793000151 CMP-binding site; other site 856793000152 The sites determining sugar specificity; other site 856793000153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793000154 NAD(P) binding site [chemical binding]; other site 856793000155 active site 856793000156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 856793000157 dimerization interface [polypeptide binding]; other site 856793000158 putative DNA binding site [nucleotide binding]; other site 856793000159 putative Zn2+ binding site [ion binding]; other site 856793000160 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 856793000161 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 856793000162 putative active site [active] 856793000163 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 856793000164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793000165 putative ADP-binding pocket [chemical binding]; other site 856793000166 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 856793000167 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 856793000168 TAP-like protein; Region: Abhydrolase_4; pfam08386 856793000169 Domain of unknown function (DUF305); Region: DUF305; pfam03713 856793000170 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 856793000171 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 856793000172 substrate binding pocket [chemical binding]; other site 856793000173 membrane-bound complex binding site; other site 856793000174 hinge residues; other site 856793000175 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793000176 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793000177 catalytic residue [active] 856793000178 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 856793000179 active site clefts [active] 856793000180 zinc binding site [ion binding]; other site 856793000181 dimer interface [polypeptide binding]; other site 856793000182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 856793000183 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 856793000184 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149 856793000185 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 856793000186 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 856793000187 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 856793000188 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 856793000189 trimer interface [polypeptide binding]; other site 856793000190 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 856793000191 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 856793000192 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 856793000193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793000194 S-adenosylmethionine binding site [chemical binding]; other site 856793000195 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 856793000196 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 856793000197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793000198 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 856793000199 Walker A motif; other site 856793000200 ATP binding site [chemical binding]; other site 856793000201 Walker B motif; other site 856793000202 arginine finger; other site 856793000203 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 856793000204 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 856793000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793000206 motif II; other site 856793000207 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 856793000208 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793000209 catalytic residue [active] 856793000210 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 856793000211 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 856793000212 ligand binding site [chemical binding]; other site 856793000213 NAD binding site [chemical binding]; other site 856793000214 dimerization interface [polypeptide binding]; other site 856793000215 catalytic site [active] 856793000216 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 856793000217 putative L-serine binding site [chemical binding]; other site 856793000218 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000220 active site 856793000221 phosphorylation site [posttranslational modification] 856793000222 intermolecular recognition site; other site 856793000223 dimerization interface [polypeptide binding]; other site 856793000224 TspO/MBR family; Region: TspO_MBR; pfam03073 856793000225 succinic semialdehyde dehydrogenase; Region: PLN02278 856793000226 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 856793000227 tetramerization interface [polypeptide binding]; other site 856793000228 NAD(P) binding site [chemical binding]; other site 856793000229 catalytic residues [active] 856793000230 Uncharacterized conserved protein [Function unknown]; Region: COG3791 856793000231 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 856793000232 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 856793000233 metal ion-dependent adhesion site (MIDAS); other site 856793000234 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 856793000235 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 856793000236 metal ion-dependent adhesion site (MIDAS); other site 856793000237 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 856793000238 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 856793000239 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 856793000240 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 856793000241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793000242 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 856793000243 Walker A/P-loop; other site 856793000244 ATP binding site [chemical binding]; other site 856793000245 Q-loop/lid; other site 856793000246 ABC transporter signature motif; other site 856793000247 Walker B; other site 856793000248 D-loop; other site 856793000249 H-loop/switch region; other site 856793000250 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 856793000251 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793000252 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 856793000253 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 856793000254 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 856793000255 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 856793000256 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 856793000257 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 856793000258 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 856793000259 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 856793000260 active site 856793000261 dimer interface [polypeptide binding]; other site 856793000262 motif 1; other site 856793000263 motif 2; other site 856793000264 motif 3; other site 856793000265 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 856793000266 anticodon binding site; other site 856793000267 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 856793000268 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 856793000269 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 856793000270 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 856793000271 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 856793000272 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793000273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793000274 Walker A/P-loop; other site 856793000275 ATP binding site [chemical binding]; other site 856793000276 Q-loop/lid; other site 856793000277 ABC transporter signature motif; other site 856793000278 Walker B; other site 856793000279 D-loop; other site 856793000280 H-loop/switch region; other site 856793000281 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 856793000282 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 856793000283 catalytic residues [active] 856793000284 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 856793000285 Family description; Region: UvrD_C_2; pfam13538 856793000286 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 856793000287 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 856793000288 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 856793000289 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 856793000290 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 856793000291 Substrate binding site; other site 856793000292 metal-binding site 856793000293 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 856793000294 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 856793000295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 856793000296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 856793000297 Predicted acetyltransferase [General function prediction only]; Region: COG2388 856793000298 PAS fold; Region: PAS_7; pfam12860 856793000299 PAS domain; Region: PAS; smart00091 856793000300 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 856793000301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793000302 dimer interface [polypeptide binding]; other site 856793000303 phosphorylation site [posttranslational modification] 856793000304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793000305 ATP binding site [chemical binding]; other site 856793000306 Mg2+ binding site [ion binding]; other site 856793000307 G-X-G motif; other site 856793000308 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000309 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000310 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 856793000311 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 856793000312 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 856793000313 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000314 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000315 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000316 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 856793000317 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 856793000318 homotetramer interface [polypeptide binding]; other site 856793000319 ligand binding site [chemical binding]; other site 856793000320 catalytic site [active] 856793000321 NAD binding site [chemical binding]; other site 856793000322 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 856793000323 shikimate kinase; Reviewed; Region: aroK; PRK00131 856793000324 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 856793000325 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 856793000326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793000327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 856793000328 dimerization interface [polypeptide binding]; other site 856793000329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793000330 dimer interface [polypeptide binding]; other site 856793000331 phosphorylation site [posttranslational modification] 856793000332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793000333 ATP binding site [chemical binding]; other site 856793000334 Mg2+ binding site [ion binding]; other site 856793000335 G-X-G motif; other site 856793000336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793000337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000338 active site 856793000339 phosphorylation site [posttranslational modification] 856793000340 intermolecular recognition site; other site 856793000341 dimerization interface [polypeptide binding]; other site 856793000342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793000343 DNA binding site [nucleotide binding] 856793000344 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 856793000345 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 856793000346 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 856793000347 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 856793000348 putative active site [active] 856793000349 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 856793000350 active site 856793000351 dimer interface [polypeptide binding]; other site 856793000352 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 856793000353 IHF dimer interface [polypeptide binding]; other site 856793000354 IHF - DNA interface [nucleotide binding]; other site 856793000355 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 856793000356 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 856793000357 RNA binding site [nucleotide binding]; other site 856793000358 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 856793000359 RNA binding site [nucleotide binding]; other site 856793000360 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 856793000361 RNA binding site [nucleotide binding]; other site 856793000362 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 856793000363 RNA binding site [nucleotide binding]; other site 856793000364 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 856793000365 RNA binding site [nucleotide binding]; other site 856793000366 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 856793000367 RNA binding site [nucleotide binding]; other site 856793000368 cytidylate kinase; Provisional; Region: cmk; PRK00023 856793000369 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 856793000370 CMP-binding site; other site 856793000371 The sites determining sugar specificity; other site 856793000372 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000373 PQQ-like domain; Region: PQQ_2; pfam13360 856793000374 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000375 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000376 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000377 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000378 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000379 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000380 PQQ-like domain; Region: PQQ_2; pfam13360 856793000381 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000382 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000383 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000384 PQQ-like domain; Region: PQQ_2; pfam13360 856793000385 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000386 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000387 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000388 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000389 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000390 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000391 PQQ-like domain; Region: PQQ_2; pfam13360 856793000392 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000393 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000394 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000395 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000396 FG-GAP repeat; Region: FG-GAP_2; pfam14312 856793000397 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 856793000398 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 856793000399 hinge; other site 856793000400 active site 856793000401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 856793000402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793000403 metal binding site [ion binding]; metal-binding site 856793000404 active site 856793000405 I-site; other site 856793000406 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793000407 dihydroorotase; Validated; Region: PRK09060 856793000408 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 856793000409 active site 856793000410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000411 Response regulator receiver domain; Region: Response_reg; pfam00072 856793000412 active site 856793000413 phosphorylation site [posttranslational modification] 856793000414 intermolecular recognition site; other site 856793000415 dimerization interface [polypeptide binding]; other site 856793000416 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 856793000417 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 856793000418 active site 856793000419 HIGH motif; other site 856793000420 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 856793000421 KMSKS motif; other site 856793000422 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 856793000423 tRNA binding surface [nucleotide binding]; other site 856793000424 anticodon binding site; other site 856793000425 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 856793000426 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 856793000427 Walker A/P-loop; other site 856793000428 ATP binding site [chemical binding]; other site 856793000429 Q-loop/lid; other site 856793000430 ABC transporter signature motif; other site 856793000431 Walker B; other site 856793000432 D-loop; other site 856793000433 H-loop/switch region; other site 856793000434 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 856793000435 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 856793000436 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 856793000437 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 856793000438 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 856793000439 30S subunit binding site; other site 856793000440 Response regulator receiver domain; Region: Response_reg; pfam00072 856793000441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000442 active site 856793000443 phosphorylation site [posttranslational modification] 856793000444 intermolecular recognition site; other site 856793000445 dimerization interface [polypeptide binding]; other site 856793000446 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 856793000447 catalytic site [active] 856793000448 putative active site [active] 856793000449 putative substrate binding site [chemical binding]; other site 856793000450 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 856793000451 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 856793000452 putative active site [active] 856793000453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 856793000454 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 856793000455 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 856793000456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 856793000457 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 856793000458 OstA-like protein; Region: OstA; cl00844 856793000459 OstA-like protein; Region: OstA; cl00844 856793000460 Zinc-finger domain; Region: zf-CHCC; cl01821 856793000461 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 856793000462 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 856793000463 putative dimer interface [polypeptide binding]; other site 856793000464 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 856793000465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 856793000466 active site 856793000467 phosphorylation site [posttranslational modification] 856793000468 recombination protein RecR; Reviewed; Region: recR; PRK00076 856793000469 RecR protein; Region: RecR; pfam02132 856793000470 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 856793000471 putative active site [active] 856793000472 putative metal-binding site [ion binding]; other site 856793000473 tetramer interface [polypeptide binding]; other site 856793000474 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 856793000475 FAD binding pocket [chemical binding]; other site 856793000476 conserved FAD binding motif [chemical binding]; other site 856793000477 phosphate binding motif [ion binding]; other site 856793000478 beta-alpha-beta structure motif; other site 856793000479 NAD binding pocket [chemical binding]; other site 856793000480 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 856793000481 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 856793000482 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 856793000483 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 856793000484 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 856793000485 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 856793000486 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 856793000487 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 856793000488 Cytochrome c2 [Energy production and conversion]; Region: COG3474 856793000489 DNA polymerase III subunit chi; Validated; Region: PRK05728 856793000490 multifunctional aminopeptidase A; Provisional; Region: PRK00913 856793000491 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 856793000492 interface (dimer of trimers) [polypeptide binding]; other site 856793000493 Substrate-binding/catalytic site; other site 856793000494 Zn-binding sites [ion binding]; other site 856793000495 elongation factor P; Validated; Region: PRK00529 856793000496 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 856793000497 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 856793000498 RNA binding site [nucleotide binding]; other site 856793000499 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 856793000500 RNA binding site [nucleotide binding]; other site 856793000501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 856793000502 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 856793000503 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 856793000504 Sel1-like repeats; Region: SEL1; smart00671 856793000505 multifunctional aminopeptidase A; Provisional; Region: PRK00913 856793000506 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 856793000507 interface (dimer of trimers) [polypeptide binding]; other site 856793000508 Substrate-binding/catalytic site; other site 856793000509 Zn-binding sites [ion binding]; other site 856793000510 Predicted permeases [General function prediction only]; Region: COG0795 856793000511 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 856793000512 Predicted permeases [General function prediction only]; Region: COG0795 856793000513 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 856793000514 VacJ like lipoprotein; Region: VacJ; cl01073 856793000515 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 856793000516 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 856793000517 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 856793000518 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 856793000519 RIP metalloprotease RseP; Region: TIGR00054 856793000520 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 856793000521 active site 856793000522 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 856793000523 protein binding site [polypeptide binding]; other site 856793000524 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 856793000525 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793000526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793000527 ABC transporter; Region: ABC_tran_2; pfam12848 856793000528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793000529 HipA N-terminal domain; Region: couple_hipA; TIGR03071 856793000530 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 856793000531 HipA-like N-terminal domain; Region: HipA_N; pfam07805 856793000532 HipA-like C-terminal domain; Region: HipA_C; pfam07804 856793000533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793000534 non-specific DNA binding site [nucleotide binding]; other site 856793000535 salt bridge; other site 856793000536 sequence-specific DNA binding site [nucleotide binding]; other site 856793000537 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 856793000538 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 856793000539 putative metal binding site [ion binding]; other site 856793000540 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 856793000541 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 856793000542 putative metal binding site [ion binding]; other site 856793000543 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 856793000544 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 856793000545 generic binding surface II; other site 856793000546 generic binding surface I; other site 856793000547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 856793000548 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 856793000549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793000550 homodimer interface [polypeptide binding]; other site 856793000551 catalytic residue [active] 856793000552 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 856793000553 Proline dehydrogenase; Region: Pro_dh; pfam01619 856793000554 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 856793000555 Glutamate binding site [chemical binding]; other site 856793000556 NAD binding site [chemical binding]; other site 856793000557 catalytic residues [active] 856793000558 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 856793000559 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 856793000560 ligand binding site [chemical binding]; other site 856793000561 flexible hinge region; other site 856793000562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793000563 Uncharacterized conserved protein [Function unknown]; Region: COG1633 856793000564 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 856793000565 diiron binding motif [ion binding]; other site 856793000566 Uncharacterized conserved protein [Function unknown]; Region: COG1633 856793000567 CCC1-related protein family; Region: CCC1_like_1; cd02437 856793000568 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 856793000569 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 856793000570 von Willebrand factor type A domain; Region: VWA_2; pfam13519 856793000571 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 856793000572 nucleoside/Zn binding site; other site 856793000573 dimer interface [polypeptide binding]; other site 856793000574 catalytic motif [active] 856793000575 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 856793000576 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 856793000577 RNA binding surface [nucleotide binding]; other site 856793000578 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 856793000579 active site 856793000580 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 856793000581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793000582 motif II; other site 856793000583 Bacitracin resistance protein BacA; Region: BacA; pfam02673 856793000584 Uncharacterized conserved protein [Function unknown]; Region: COG2353 856793000585 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 856793000586 YceI-like domain; Region: YceI; pfam04264 856793000587 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 856793000588 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 856793000589 active site 856793000590 catalytic residues [active] 856793000591 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 856793000592 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 856793000593 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 856793000594 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 856793000595 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 856793000596 N-terminal domain interface [polypeptide binding]; other site 856793000597 dimer interface [polypeptide binding]; other site 856793000598 substrate binding pocket (H-site) [chemical binding]; other site 856793000599 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 856793000600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 856793000601 putative NAD(P) binding site [chemical binding]; other site 856793000602 PAS domain S-box; Region: sensory_box; TIGR00229 856793000603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793000604 putative active site [active] 856793000605 heme pocket [chemical binding]; other site 856793000606 PAS fold; Region: PAS_3; pfam08447 856793000607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793000608 putative active site [active] 856793000609 heme pocket [chemical binding]; other site 856793000610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793000611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793000612 dimer interface [polypeptide binding]; other site 856793000613 phosphorylation site [posttranslational modification] 856793000614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793000615 ATP binding site [chemical binding]; other site 856793000616 Mg2+ binding site [ion binding]; other site 856793000617 G-X-G motif; other site 856793000618 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 856793000619 putative catalytic residue [active] 856793000620 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 856793000621 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 856793000622 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 856793000623 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 856793000624 DsbD alpha interface [polypeptide binding]; other site 856793000625 catalytic residues [active] 856793000626 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 856793000627 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 856793000628 acyl-activating enzyme (AAE) consensus motif; other site 856793000629 putative AMP binding site [chemical binding]; other site 856793000630 putative active site [active] 856793000631 putative CoA binding site [chemical binding]; other site 856793000632 aspartate aminotransferase; Provisional; Region: PRK06108 856793000633 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 856793000634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793000635 homodimer interface [polypeptide binding]; other site 856793000636 catalytic residue [active] 856793000637 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 856793000638 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 856793000639 Peptidase family M23; Region: Peptidase_M23; pfam01551 856793000640 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 856793000641 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 856793000642 putative ligand binding site [chemical binding]; other site 856793000643 NAD binding site [chemical binding]; other site 856793000644 dimerization interface [polypeptide binding]; other site 856793000645 catalytic site [active] 856793000646 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 856793000647 Protein of unknown function (DUF983); Region: DUF983; cl02211 856793000648 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 856793000649 Subunit III/VIIa interface [polypeptide binding]; other site 856793000650 Phospholipid binding site [chemical binding]; other site 856793000651 Subunit I/III interface [polypeptide binding]; other site 856793000652 Subunit III/VIb interface [polypeptide binding]; other site 856793000653 Subunit III/VIa interface; other site 856793000654 Subunit III/Vb interface [polypeptide binding]; other site 856793000655 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 856793000656 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 856793000657 UbiA prenyltransferase family; Region: UbiA; pfam01040 856793000658 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 856793000659 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 856793000660 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 856793000661 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 856793000662 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 856793000663 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 856793000664 protease TldD; Provisional; Region: tldD; PRK10735 856793000665 peptidase PmbA; Provisional; Region: PRK11040 856793000666 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 856793000667 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 856793000668 protein binding site [polypeptide binding]; other site 856793000669 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 856793000670 Catalytic dyad [active] 856793000671 C-terminal peptidase (prc); Region: prc; TIGR00225 856793000672 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 856793000673 protein binding site [polypeptide binding]; other site 856793000674 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 856793000675 Catalytic dyad [active] 856793000676 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 856793000677 C-terminal peptidase (prc); Region: prc; TIGR00225 856793000678 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 856793000679 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 856793000680 Catalytic dyad [active] 856793000681 C-terminal peptidase (prc); Region: prc; TIGR00225 856793000682 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 856793000683 protein binding site [polypeptide binding]; other site 856793000684 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 856793000685 Catalytic dyad [active] 856793000686 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 856793000687 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 856793000688 Subunit I/III interface [polypeptide binding]; other site 856793000689 D-pathway; other site 856793000690 Subunit I/VIIc interface [polypeptide binding]; other site 856793000691 Subunit I/IV interface [polypeptide binding]; other site 856793000692 Subunit I/II interface [polypeptide binding]; other site 856793000693 Low-spin heme (heme a) binding site [chemical binding]; other site 856793000694 Subunit I/VIIa interface [polypeptide binding]; other site 856793000695 Subunit I/VIa interface [polypeptide binding]; other site 856793000696 Dimer interface; other site 856793000697 Putative water exit pathway; other site 856793000698 Binuclear center (heme a3/CuB) [ion binding]; other site 856793000699 K-pathway; other site 856793000700 Subunit I/Vb interface [polypeptide binding]; other site 856793000701 Putative proton exit pathway; other site 856793000702 Subunit I/VIb interface; other site 856793000703 Subunit I/VIc interface [polypeptide binding]; other site 856793000704 Electron transfer pathway; other site 856793000705 Subunit I/VIIIb interface [polypeptide binding]; other site 856793000706 Subunit I/VIIb interface [polypeptide binding]; other site 856793000707 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 856793000708 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 856793000709 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 856793000710 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 856793000711 active site 856793000712 catalytic residues [active] 856793000713 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 856793000714 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 856793000715 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 856793000716 RNA methyltransferase, RsmE family; Region: TIGR00046 856793000717 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 856793000718 UbiA prenyltransferase family; Region: UbiA; pfam01040 856793000719 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 856793000720 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 856793000721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793000722 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 856793000723 NAD(P) binding site [chemical binding]; other site 856793000724 active site 856793000725 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 856793000726 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 856793000727 dimer interface [polypeptide binding]; other site 856793000728 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 856793000729 active site 856793000730 Fe binding site [ion binding]; other site 856793000731 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 856793000732 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 856793000733 maleylacetoacetate isomerase; Region: maiA; TIGR01262 856793000734 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 856793000735 C-terminal domain interface [polypeptide binding]; other site 856793000736 GSH binding site (G-site) [chemical binding]; other site 856793000737 putative dimer interface [polypeptide binding]; other site 856793000738 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 856793000739 dimer interface [polypeptide binding]; other site 856793000740 N-terminal domain interface [polypeptide binding]; other site 856793000741 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 856793000742 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 856793000743 cofactor binding site; other site 856793000744 metal binding site [ion binding]; metal-binding site 856793000745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 856793000746 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 856793000747 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 856793000748 DNA-binding site [nucleotide binding]; DNA binding site 856793000749 RNA-binding motif; other site 856793000750 DEAD-like helicases superfamily; Region: DEXDc; smart00487 856793000751 Z1 domain; Region: Z1; pfam10593 856793000752 Methyltransferase domain; Region: Methyltransf_26; pfam13659 856793000753 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 856793000754 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 856793000755 D5 N terminal like; Region: D5_N; pfam08706 856793000756 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 856793000757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793000758 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 856793000759 active site 856793000760 Int/Topo IB signature motif; other site 856793000761 DNA binding site [nucleotide binding] 856793000762 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 856793000763 nucleophilic elbow; other site 856793000764 catalytic triad; other site 856793000765 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 856793000766 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 856793000767 Autoinducer binding domain; Region: Autoind_bind; pfam03472 856793000768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 856793000769 DNA binding residues [nucleotide binding] 856793000770 dimerization interface [polypeptide binding]; other site 856793000771 Autoinducer binding domain; Region: Autoind_bind; pfam03472 856793000772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 856793000773 DNA binding residues [nucleotide binding] 856793000774 dimerization interface [polypeptide binding]; other site 856793000775 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 856793000776 Isochorismatase family; Region: Isochorismatase; pfam00857 856793000777 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 856793000778 catalytic triad [active] 856793000779 dimer interface [polypeptide binding]; other site 856793000780 conserved cis-peptide bond; other site 856793000781 Pirin-related protein [General function prediction only]; Region: COG1741 856793000782 Pirin; Region: Pirin; pfam02678 856793000783 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 856793000784 Predicted transcriptional regulators [Transcription]; Region: COG1733 856793000785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 856793000786 dimerization interface [polypeptide binding]; other site 856793000787 putative DNA binding site [nucleotide binding]; other site 856793000788 putative Zn2+ binding site [ion binding]; other site 856793000789 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 856793000790 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 856793000791 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 856793000792 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 856793000793 NADH(P)-binding; Region: NAD_binding_10; pfam13460 856793000794 NAD binding site [chemical binding]; other site 856793000795 substrate binding site [chemical binding]; other site 856793000796 putative active site [active] 856793000797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793000798 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 856793000799 NAD(P) binding site [chemical binding]; other site 856793000800 active site 856793000801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 856793000802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 856793000803 Pirin-related protein [General function prediction only]; Region: COG1741 856793000804 Pirin; Region: Pirin; pfam02678 856793000805 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 856793000806 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 856793000807 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 856793000808 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 856793000809 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 856793000810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793000811 active site 856793000812 hypothetical protein; Validated; Region: PRK07198 856793000813 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 856793000814 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 856793000815 dimerization interface [polypeptide binding]; other site 856793000816 active site 856793000817 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 856793000818 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 856793000819 tetrameric interface [polypeptide binding]; other site 856793000820 NAD binding site [chemical binding]; other site 856793000821 catalytic residues [active] 856793000822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793000823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793000824 active site 856793000825 phosphorylation site [posttranslational modification] 856793000826 intermolecular recognition site; other site 856793000827 dimerization interface [polypeptide binding]; other site 856793000828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793000829 DNA binding site [nucleotide binding] 856793000830 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 856793000831 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 856793000832 NAD binding site [chemical binding]; other site 856793000833 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 856793000834 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 856793000835 putative trimer interface [polypeptide binding]; other site 856793000836 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 856793000837 putative CoA binding site [chemical binding]; other site 856793000838 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 856793000839 putative trimer interface [polypeptide binding]; other site 856793000840 putative active site [active] 856793000841 putative substrate binding site [chemical binding]; other site 856793000842 putative CoA binding site [chemical binding]; other site 856793000843 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 856793000844 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 856793000845 inhibitor-cofactor binding pocket; inhibition site 856793000846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793000847 catalytic residue [active] 856793000848 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 856793000849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793000850 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 856793000851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793000852 Walker A motif; other site 856793000853 ATP binding site [chemical binding]; other site 856793000854 Walker B motif; other site 856793000855 arginine finger; other site 856793000856 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 856793000857 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 856793000858 hypothetical protein; Validated; Region: PRK00153 856793000859 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 856793000860 putative catalytic site [active] 856793000861 putative phosphate binding site [ion binding]; other site 856793000862 active site 856793000863 metal binding site A [ion binding]; metal-binding site 856793000864 DNA binding site [nucleotide binding] 856793000865 putative AP binding site [nucleotide binding]; other site 856793000866 putative metal binding site B [ion binding]; other site 856793000867 Ceramidase; Region: Ceramidase; pfam05875 856793000868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 856793000869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 856793000870 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 856793000871 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 856793000872 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 856793000873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793000874 FeS/SAM binding site; other site 856793000875 Herpesvirus BLRF2 protein; Region: Herpes_BLRF2; cl17417 856793000876 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 856793000877 Ca2+ binding site [ion binding]; other site 856793000878 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 856793000879 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 856793000880 G1 box; other site 856793000881 putative GEF interaction site [polypeptide binding]; other site 856793000882 GTP/Mg2+ binding site [chemical binding]; other site 856793000883 Switch I region; other site 856793000884 G2 box; other site 856793000885 G3 box; other site 856793000886 Switch II region; other site 856793000887 G4 box; other site 856793000888 G5 box; other site 856793000889 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 856793000890 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 856793000891 Chorismate mutase type II; Region: CM_2; smart00830 856793000892 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 856793000893 nudix motif; other site 856793000894 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 856793000895 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 856793000896 substrate binding site [chemical binding]; other site 856793000897 hexamer interface [polypeptide binding]; other site 856793000898 metal binding site [ion binding]; metal-binding site 856793000899 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 856793000900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 856793000901 active site 856793000902 metal binding site [ion binding]; metal-binding site 856793000903 DNA repair protein RadA; Provisional; Region: PRK11823 856793000904 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 856793000905 Walker A motif/ATP binding site; other site 856793000906 ATP binding site [chemical binding]; other site 856793000907 Walker B motif; other site 856793000908 Colicin V production protein; Region: Colicin_V; pfam02674 856793000909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793000910 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 856793000911 NAD(P) binding site [chemical binding]; other site 856793000912 active site 856793000913 GTP-binding protein Der; Reviewed; Region: PRK00093 856793000914 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 856793000915 G1 box; other site 856793000916 GTP/Mg2+ binding site [chemical binding]; other site 856793000917 Switch I region; other site 856793000918 G2 box; other site 856793000919 Switch II region; other site 856793000920 G3 box; other site 856793000921 G4 box; other site 856793000922 G5 box; other site 856793000923 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 856793000924 G1 box; other site 856793000925 GTP/Mg2+ binding site [chemical binding]; other site 856793000926 Switch I region; other site 856793000927 G2 box; other site 856793000928 G3 box; other site 856793000929 Switch II region; other site 856793000930 G4 box; other site 856793000931 G5 box; other site 856793000932 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 856793000933 Trp docking motif [polypeptide binding]; other site 856793000934 active site 856793000935 PQQ-like domain; Region: PQQ_2; pfam13360 856793000936 PQQ-like domain; Region: PQQ_2; pfam13360 856793000937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 856793000938 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 856793000939 isocitrate dehydrogenase; Validated; Region: PRK08299 856793000940 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 856793000941 AMIN domain; Region: AMIN; pfam11741 856793000942 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 856793000943 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 856793000944 active site 856793000945 metal binding site [ion binding]; metal-binding site 856793000946 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 856793000947 RNA binding site [nucleotide binding]; other site 856793000948 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 856793000949 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 856793000950 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 856793000951 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 856793000952 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 856793000953 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 856793000954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 856793000955 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 856793000956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 856793000957 catalytic loop [active] 856793000958 iron binding site [ion binding]; other site 856793000959 Usg-like family; Region: Usg; cl11567 856793000960 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 856793000961 oligomerisation interface [polypeptide binding]; other site 856793000962 mobile loop; other site 856793000963 roof hairpin; other site 856793000964 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 856793000965 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 856793000966 ring oligomerisation interface [polypeptide binding]; other site 856793000967 ATP/Mg binding site [chemical binding]; other site 856793000968 stacking interactions; other site 856793000969 hinge regions; other site 856793000970 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 856793000971 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 856793000972 DNA binding site [nucleotide binding] 856793000973 catalytic residue [active] 856793000974 H2TH interface [polypeptide binding]; other site 856793000975 putative catalytic residues [active] 856793000976 turnover-facilitating residue; other site 856793000977 intercalation triad [nucleotide binding]; other site 856793000978 8OG recognition residue [nucleotide binding]; other site 856793000979 putative reading head residues; other site 856793000980 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 856793000981 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 856793000982 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 856793000983 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 856793000984 DnaA N-terminal domain; Region: DnaA_N; pfam11638 856793000985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793000986 Walker A motif; other site 856793000987 ATP binding site [chemical binding]; other site 856793000988 Walker B motif; other site 856793000989 arginine finger; other site 856793000990 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 856793000991 DnaA box-binding interface [nucleotide binding]; other site 856793000992 DNA polymerase III subunit beta; Validated; Region: PRK05643 856793000993 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 856793000994 putative DNA binding surface [nucleotide binding]; other site 856793000995 dimer interface [polypeptide binding]; other site 856793000996 beta-clamp/clamp loader binding surface; other site 856793000997 beta-clamp/translesion DNA polymerase binding surface; other site 856793000998 recombination protein F; Reviewed; Region: recF; PRK00064 856793000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793001000 Walker A/P-loop; other site 856793001001 ATP binding site [chemical binding]; other site 856793001002 Q-loop/lid; other site 856793001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793001004 ABC transporter signature motif; other site 856793001005 Walker B; other site 856793001006 D-loop; other site 856793001007 H-loop/switch region; other site 856793001008 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 856793001009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793001010 Mg2+ binding site [ion binding]; other site 856793001011 G-X-G motif; other site 856793001012 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 856793001013 anchoring element; other site 856793001014 dimer interface [polypeptide binding]; other site 856793001015 ATP binding site [chemical binding]; other site 856793001016 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 856793001017 active site 856793001018 putative metal-binding site [ion binding]; other site 856793001019 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 856793001020 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 856793001021 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 856793001022 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793001023 active site 856793001024 HIGH motif; other site 856793001025 nucleotide binding site [chemical binding]; other site 856793001026 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 856793001027 KMSK motif region; other site 856793001028 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 856793001029 tRNA binding surface [nucleotide binding]; other site 856793001030 anticodon binding site; other site 856793001031 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 856793001032 AAA-like domain; Region: AAA_10; pfam12846 856793001033 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 856793001034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 856793001035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 856793001036 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 856793001037 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 856793001038 SlyX; Region: SlyX; pfam04102 856793001039 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 856793001040 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 856793001041 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 856793001042 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 856793001043 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 856793001044 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 856793001045 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 856793001046 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 856793001047 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 856793001048 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 856793001049 protein binding site [polypeptide binding]; other site 856793001050 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 856793001051 protein binding site [polypeptide binding]; other site 856793001052 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 856793001053 HflC protein; Region: hflC; TIGR01932 856793001054 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 856793001055 HflK protein; Region: hflK; TIGR01933 856793001056 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 856793001057 Domain of unknown function DUF59; Region: DUF59; pfam01883 856793001058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 856793001059 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 856793001060 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 856793001061 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 856793001062 folate binding site [chemical binding]; other site 856793001063 NADP+ binding site [chemical binding]; other site 856793001064 thymidylate synthase; Reviewed; Region: thyA; PRK01827 856793001065 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 856793001066 dimerization interface [polypeptide binding]; other site 856793001067 active site 856793001068 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 856793001069 Ferritin-like domain; Region: Ferritin; pfam00210 856793001070 dimerization interface [polypeptide binding]; other site 856793001071 DPS ferroxidase diiron center [ion binding]; other site 856793001072 ion pore; other site 856793001073 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 856793001074 O-Antigen ligase; Region: Wzy_C; pfam04932 856793001075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 856793001076 TPR motif; other site 856793001077 binding surface 856793001078 Stringent starvation protein B; Region: SspB; cl01120 856793001079 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 856793001080 macrolide transporter subunit MacA; Provisional; Region: PRK11578 856793001081 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 856793001082 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793001083 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 856793001084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 856793001085 Walker A/P-loop; other site 856793001086 ATP binding site [chemical binding]; other site 856793001087 Q-loop/lid; other site 856793001088 ABC transporter signature motif; other site 856793001089 Walker B; other site 856793001090 D-loop; other site 856793001091 H-loop/switch region; other site 856793001092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 856793001093 FtsX-like permease family; Region: FtsX; pfam02687 856793001094 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 856793001095 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 856793001096 ABC1 family; Region: ABC1; pfam03109 856793001097 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 856793001098 COQ9; Region: COQ9; pfam08511 856793001099 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 856793001100 N-formylglutamate amidohydrolase; Region: FGase; cl01522 856793001101 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 856793001102 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 856793001103 O-Antigen ligase; Region: Wzy_C; pfam04932 856793001104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793001105 TPR motif; other site 856793001106 binding surface 856793001107 acetyl-CoA synthetase; Provisional; Region: PRK00174 856793001108 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 856793001109 active site 856793001110 CoA binding site [chemical binding]; other site 856793001111 acyl-activating enzyme (AAE) consensus motif; other site 856793001112 AMP binding site [chemical binding]; other site 856793001113 acetate binding site [chemical binding]; other site 856793001114 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 856793001115 EamA-like transporter family; Region: EamA; pfam00892 856793001116 EamA-like transporter family; Region: EamA; pfam00892 856793001117 EVE domain; Region: EVE; pfam01878 856793001118 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 856793001119 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 856793001120 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 856793001121 UGMP family protein; Validated; Region: PRK09604 856793001122 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 856793001123 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 856793001124 domain interfaces; other site 856793001125 active site 856793001126 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 856793001127 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 856793001128 active site 856793001129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 856793001130 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 856793001131 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 856793001132 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 856793001133 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 856793001134 inhibitor-cofactor binding pocket; inhibition site 856793001135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793001136 catalytic residue [active] 856793001137 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 856793001138 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 856793001139 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 856793001140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 856793001141 putative metal binding site; other site 856793001142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 856793001143 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 856793001144 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 856793001145 SLBB domain; Region: SLBB; pfam10531 856793001146 SLBB domain; Region: SLBB; pfam10531 856793001147 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 856793001148 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 856793001149 Protein of unknown function, DUF486; Region: DUF486; cl01236 856793001150 PAS domain; Region: PAS_9; pfam13426 856793001151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793001152 PAS domain; Region: PAS_9; pfam13426 856793001153 putative active site [active] 856793001154 heme pocket [chemical binding]; other site 856793001155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793001156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793001157 dimer interface [polypeptide binding]; other site 856793001158 putative CheW interface [polypeptide binding]; other site 856793001159 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 856793001160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001161 active site 856793001162 phosphorylation site [posttranslational modification] 856793001163 intermolecular recognition site; other site 856793001164 dimerization interface [polypeptide binding]; other site 856793001165 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 856793001166 putative binding surface; other site 856793001167 active site 856793001168 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 856793001169 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 856793001170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793001171 ATP binding site [chemical binding]; other site 856793001172 Mg2+ binding site [ion binding]; other site 856793001173 G-X-G motif; other site 856793001174 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 856793001175 Response regulator receiver domain; Region: Response_reg; pfam00072 856793001176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001177 active site 856793001178 phosphorylation site [posttranslational modification] 856793001179 intermolecular recognition site; other site 856793001180 dimerization interface [polypeptide binding]; other site 856793001181 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 856793001182 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 856793001183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001184 active site 856793001185 phosphorylation site [posttranslational modification] 856793001186 intermolecular recognition site; other site 856793001187 dimerization interface [polypeptide binding]; other site 856793001188 CheB methylesterase; Region: CheB_methylest; pfam01339 856793001189 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 856793001190 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 856793001191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793001192 S-adenosylmethionine binding site [chemical binding]; other site 856793001193 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 856793001194 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 856793001195 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 856793001196 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 856793001197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793001198 NAD(P) binding site [chemical binding]; other site 856793001199 active site 856793001200 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 856793001201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793001202 putative ADP-binding pocket [chemical binding]; other site 856793001203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 856793001204 putative substrate translocation pore; other site 856793001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 856793001206 Tetratricopeptide repeat; Region: TPR_16; pfam13432 856793001207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793001208 TPR motif; other site 856793001209 binding surface 856793001210 TPR repeat; Region: TPR_11; pfam13414 856793001211 TPR repeat; Region: TPR_11; pfam13414 856793001212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793001213 binding surface 856793001214 TPR motif; other site 856793001215 TPR repeat; Region: TPR_11; pfam13414 856793001216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793001217 binding surface 856793001218 TPR motif; other site 856793001219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 856793001220 TPR repeat; Region: TPR_11; pfam13414 856793001221 binding surface 856793001222 TPR motif; other site 856793001223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793001224 binding surface 856793001225 Tetratricopeptide repeat; Region: TPR_16; pfam13432 856793001226 TPR motif; other site 856793001227 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 856793001228 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 856793001229 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 856793001230 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 856793001231 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 856793001232 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001234 active site 856793001235 phosphorylation site [posttranslational modification] 856793001236 intermolecular recognition site; other site 856793001237 dimerization interface [polypeptide binding]; other site 856793001238 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 856793001239 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 856793001240 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 856793001241 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 856793001242 NADP-binding site; other site 856793001243 homotetramer interface [polypeptide binding]; other site 856793001244 substrate binding site [chemical binding]; other site 856793001245 homodimer interface [polypeptide binding]; other site 856793001246 active site 856793001247 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 856793001248 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 856793001249 NADP binding site [chemical binding]; other site 856793001250 active site 856793001251 putative substrate binding site [chemical binding]; other site 856793001252 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 856793001253 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 856793001254 Substrate binding site; other site 856793001255 Arginase family; Region: Arginase; cd09989 856793001256 active site 856793001257 Mn binding site [ion binding]; other site 856793001258 oligomer interface [polypeptide binding]; other site 856793001259 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 856793001260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793001261 non-specific DNA binding site [nucleotide binding]; other site 856793001262 salt bridge; other site 856793001263 sequence-specific DNA binding site [nucleotide binding]; other site 856793001264 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 856793001265 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 856793001266 active site 856793001267 Zn binding site [ion binding]; other site 856793001268 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 856793001269 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 856793001270 active site 856793001271 Zn binding site [ion binding]; other site 856793001272 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 856793001273 Uncharacterized conserved protein [Function unknown]; Region: COG4121 856793001274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 856793001275 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 856793001276 Mg++ binding site [ion binding]; other site 856793001277 putative catalytic motif [active] 856793001278 substrate binding site [chemical binding]; other site 856793001279 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 856793001280 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 856793001281 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 856793001282 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 856793001283 active site residue [active] 856793001284 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 856793001285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 856793001286 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 856793001287 dimerization interface [polypeptide binding]; other site 856793001288 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 856793001289 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 856793001290 dimer interface [polypeptide binding]; other site 856793001291 decamer (pentamer of dimers) interface [polypeptide binding]; other site 856793001292 catalytic triad [active] 856793001293 peroxidatic and resolving cysteines [active] 856793001294 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 856793001295 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 856793001296 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 856793001297 Mechanosensitive ion channel; Region: MS_channel; pfam00924 856793001298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 856793001299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 856793001300 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 856793001301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 856793001302 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 856793001303 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 856793001304 putative ligand binding site [chemical binding]; other site 856793001305 Predicted methyltransferases [General function prediction only]; Region: COG0313 856793001306 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 856793001307 putative SAM binding site [chemical binding]; other site 856793001308 putative homodimer interface [polypeptide binding]; other site 856793001309 hypothetical protein; Reviewed; Region: PRK12497 856793001310 BON domain; Region: BON; pfam04972 856793001311 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 856793001312 BON domain; Region: BON; pfam04972 856793001313 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 856793001314 Tetratricopeptide repeat; Region: TPR_9; pfam13371 856793001315 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 856793001316 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793001317 ligand binding site [chemical binding]; other site 856793001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 856793001319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 856793001320 binding surface 856793001321 TPR motif; other site 856793001322 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 856793001323 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 856793001324 Ligand Binding Site [chemical binding]; other site 856793001325 FtsH Extracellular; Region: FtsH_ext; pfam06480 856793001326 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 856793001327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793001328 Walker A motif; other site 856793001329 ATP binding site [chemical binding]; other site 856793001330 Walker B motif; other site 856793001331 arginine finger; other site 856793001332 Peptidase family M41; Region: Peptidase_M41; pfam01434 856793001333 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 856793001334 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 856793001335 active site 856793001336 substrate binding site [chemical binding]; other site 856793001337 metal binding site [ion binding]; metal-binding site 856793001338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 856793001339 active site 856793001340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 856793001341 catalytic tetrad [active] 856793001342 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 856793001343 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 856793001344 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 856793001345 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 856793001346 GDP-binding site [chemical binding]; other site 856793001347 ACT binding site; other site 856793001348 IMP binding site; other site 856793001349 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 856793001350 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 856793001351 active site 856793001352 ATP binding site [chemical binding]; other site 856793001353 substrate binding site [chemical binding]; other site 856793001354 activation loop (A-loop); other site 856793001355 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 856793001356 TadE-like protein; Region: TadE; pfam07811 856793001357 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 856793001358 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 856793001359 von Willebrand factor type A domain; Region: VWA_2; pfam13519 856793001360 metal ion-dependent adhesion site (MIDAS); other site 856793001361 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 856793001362 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 856793001363 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 856793001364 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 856793001365 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 856793001366 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 856793001367 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 856793001368 Type IV pili component [Cell motility and secretion]; Region: COG5461 856793001369 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 856793001370 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 856793001371 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 856793001372 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 856793001373 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 856793001374 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 856793001375 ATP binding site [chemical binding]; other site 856793001376 Walker A motif; other site 856793001377 hexamer interface [polypeptide binding]; other site 856793001378 Walker B motif; other site 856793001379 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 856793001380 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 856793001381 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 856793001382 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 856793001383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 856793001384 binding surface 856793001385 TPR motif; other site 856793001386 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 856793001387 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 856793001388 tape measure domain; Region: tape_meas_nterm; TIGR02675 856793001389 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 856793001390 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 856793001391 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 856793001392 Terminase-like family; Region: Terminase_6; pfam03237 856793001393 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 856793001394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793001395 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 856793001396 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 856793001397 DNA methylase; Region: N6_N4_Mtase; pfam01555 856793001398 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 856793001399 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 856793001400 Uncharacterized conserved protein [Function unknown]; Region: COG3743 856793001401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 856793001402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793001403 salt bridge; other site 856793001404 non-specific DNA binding site [nucleotide binding]; other site 856793001405 sequence-specific DNA binding site [nucleotide binding]; other site 856793001406 Haemagglutinin-neuraminidase; Region: HN; pfam00423 856793001407 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 856793001408 SAP domain; Region: SAP; pfam02037 856793001409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 856793001410 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 856793001411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793001412 AAA domain; Region: AAA_23; pfam13476 856793001413 Walker A/P-loop; other site 856793001414 ATP binding site [chemical binding]; other site 856793001415 Helix-turn-helix domain; Region: HTH_17; cl17695 856793001416 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793001417 active site 856793001418 DNA binding site [nucleotide binding] 856793001419 Int/Topo IB signature motif; other site 856793001420 Response regulator receiver domain; Region: Response_reg; pfam00072 856793001421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001422 active site 856793001423 phosphorylation site [posttranslational modification] 856793001424 intermolecular recognition site; other site 856793001425 dimerization interface [polypeptide binding]; other site 856793001426 glucokinase; Provisional; Region: glk; PRK00292 856793001427 glucokinase, proteobacterial type; Region: glk; TIGR00749 856793001428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793001429 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 856793001430 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 856793001431 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 856793001432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 856793001433 RNA binding surface [nucleotide binding]; other site 856793001434 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 856793001435 active site 856793001436 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 856793001437 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 856793001438 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 856793001439 NAD binding site [chemical binding]; other site 856793001440 Phe binding site; other site 856793001441 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 856793001442 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 856793001443 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 856793001444 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 856793001445 N- and C-terminal domain interface [polypeptide binding]; other site 856793001446 active site 856793001447 MgATP binding site [chemical binding]; other site 856793001448 catalytic site [active] 856793001449 metal binding site [ion binding]; metal-binding site 856793001450 glycerol binding site [chemical binding]; other site 856793001451 homotetramer interface [polypeptide binding]; other site 856793001452 homodimer interface [polypeptide binding]; other site 856793001453 FBP binding site [chemical binding]; other site 856793001454 protein IIAGlc interface [polypeptide binding]; other site 856793001455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 856793001456 RNA binding site [nucleotide binding]; other site 856793001457 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 856793001458 Maf-like protein; Region: Maf; pfam02545 856793001459 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 856793001460 active site 856793001461 dimer interface [polypeptide binding]; other site 856793001462 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 856793001463 rRNA binding site [nucleotide binding]; other site 856793001464 predicted 30S ribosome binding site; other site 856793001465 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 856793001466 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 856793001467 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 856793001468 hinge; other site 856793001469 active site 856793001470 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 856793001471 trimer interface [polypeptide binding]; other site 856793001472 active site 856793001473 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 856793001474 arsenical-resistance protein; Region: acr3; TIGR00832 856793001475 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 856793001476 Low molecular weight phosphatase family; Region: LMWPc; cd00115 856793001477 active site 856793001478 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 856793001479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 856793001480 putative metal binding site [ion binding]; other site 856793001481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 856793001482 dimerization interface [polypeptide binding]; other site 856793001483 putative DNA binding site [nucleotide binding]; other site 856793001484 putative Zn2+ binding site [ion binding]; other site 856793001485 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 856793001486 potassium/proton antiporter; Reviewed; Region: PRK05326 856793001487 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 856793001488 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 856793001489 putative catalytic site [active] 856793001490 putative phosphate binding site [ion binding]; other site 856793001491 active site 856793001492 metal binding site A [ion binding]; metal-binding site 856793001493 DNA binding site [nucleotide binding] 856793001494 putative AP binding site [nucleotide binding]; other site 856793001495 putative metal binding site B [ion binding]; other site 856793001496 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 856793001497 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 856793001498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 856793001499 Zn2+ binding site [ion binding]; other site 856793001500 Mg2+ binding site [ion binding]; other site 856793001501 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 856793001502 Sporulation related domain; Region: SPOR; pfam05036 856793001503 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 856793001504 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 856793001505 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 856793001506 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 856793001507 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 856793001508 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 856793001509 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 856793001510 Predicted ATPase [General function prediction only]; Region: COG1485 856793001511 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 856793001512 malate dehydrogenase; Reviewed; Region: PRK06223 856793001513 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 856793001514 NAD(P) binding site [chemical binding]; other site 856793001515 dimer interface [polypeptide binding]; other site 856793001516 tetramer (dimer of dimers) interface [polypeptide binding]; other site 856793001517 substrate binding site [chemical binding]; other site 856793001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793001519 sequence-specific DNA binding site [nucleotide binding]; other site 856793001520 salt bridge; other site 856793001521 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 856793001522 catalytic residue [active] 856793001523 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 856793001524 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 856793001525 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 856793001526 CoA-ligase; Region: Ligase_CoA; pfam00549 856793001527 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 856793001528 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 856793001529 CoA binding domain; Region: CoA_binding; smart00881 856793001530 CoA-ligase; Region: Ligase_CoA; pfam00549 856793001531 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 856793001532 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 856793001533 TPP-binding site [chemical binding]; other site 856793001534 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 856793001535 PYR/PP interface [polypeptide binding]; other site 856793001536 dimer interface [polypeptide binding]; other site 856793001537 TPP binding site [chemical binding]; other site 856793001538 multidrug efflux system protein; Provisional; Region: PRK11431 856793001539 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 856793001540 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 856793001541 E3 interaction surface; other site 856793001542 lipoyl attachment site [posttranslational modification]; other site 856793001543 e3 binding domain; Region: E3_binding; pfam02817 856793001544 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 856793001545 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 856793001546 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 856793001547 active site 856793001548 Zn binding site [ion binding]; other site 856793001549 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 856793001550 catalytic site [active] 856793001551 putative active site [active] 856793001552 putative substrate binding site [chemical binding]; other site 856793001553 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 856793001554 putative active site; other site 856793001555 signature motif; other site 856793001556 putative triphosphate binding site [ion binding]; other site 856793001557 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 856793001558 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 856793001559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 856793001560 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 856793001561 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 856793001562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793001563 active site 856793001564 DNA binding site [nucleotide binding] 856793001565 Int/Topo IB signature motif; other site 856793001566 Protein of unknown function, DUF484; Region: DUF484; cl17449 856793001567 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 856793001568 active site 856793001569 intersubunit interactions; other site 856793001570 catalytic residue [active] 856793001571 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 856793001572 putative active site [active] 856793001573 primosomal protein N' Region: priA; TIGR00595 856793001574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793001575 ATP binding site [chemical binding]; other site 856793001576 putative Mg++ binding site [ion binding]; other site 856793001577 TraX protein; Region: TraX; cl05434 856793001578 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 856793001579 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 856793001580 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 856793001581 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 856793001582 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 856793001583 beta subunit interaction interface [polypeptide binding]; other site 856793001584 Walker A motif; other site 856793001585 ATP binding site [chemical binding]; other site 856793001586 Walker B motif; other site 856793001587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 856793001588 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 856793001589 core domain interface [polypeptide binding]; other site 856793001590 delta subunit interface [polypeptide binding]; other site 856793001591 epsilon subunit interface [polypeptide binding]; other site 856793001592 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 856793001593 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 856793001594 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 856793001595 alpha subunit interaction interface [polypeptide binding]; other site 856793001596 Walker A motif; other site 856793001597 ATP binding site [chemical binding]; other site 856793001598 Walker B motif; other site 856793001599 inhibitor binding site; inhibition site 856793001600 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 856793001601 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 856793001602 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 856793001603 gamma subunit interface [polypeptide binding]; other site 856793001604 epsilon subunit interface [polypeptide binding]; other site 856793001605 LBP interface [polypeptide binding]; other site 856793001606 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 856793001607 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 856793001608 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 856793001609 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 856793001610 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 856793001611 dimer interface [polypeptide binding]; other site 856793001612 putative anticodon binding site; other site 856793001613 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 856793001614 motif 1; other site 856793001615 active site 856793001616 motif 2; other site 856793001617 motif 3; other site 856793001618 YcfA-like protein; Region: YcfA; pfam07927 856793001619 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 856793001620 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 856793001621 putative FMN binding site [chemical binding]; other site 856793001622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001624 active site 856793001625 phosphorylation site [posttranslational modification] 856793001626 intermolecular recognition site; other site 856793001627 dimerization interface [polypeptide binding]; other site 856793001628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793001629 DNA binding site [nucleotide binding] 856793001630 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 856793001631 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 856793001632 excinuclease ABC subunit B; Provisional; Region: PRK05298 856793001633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793001634 ATP binding site [chemical binding]; other site 856793001635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793001636 nucleotide binding region [chemical binding]; other site 856793001637 ATP-binding site [chemical binding]; other site 856793001638 Ultra-violet resistance protein B; Region: UvrB; pfam12344 856793001639 UvrB/uvrC motif; Region: UVR; pfam02151 856793001640 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 856793001641 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 856793001642 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 856793001643 putative active site [active] 856793001644 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 856793001645 GTP-binding protein LepA; Provisional; Region: PRK05433 856793001646 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 856793001647 G1 box; other site 856793001648 putative GEF interaction site [polypeptide binding]; other site 856793001649 GTP/Mg2+ binding site [chemical binding]; other site 856793001650 Switch I region; other site 856793001651 G2 box; other site 856793001652 G3 box; other site 856793001653 Switch II region; other site 856793001654 G4 box; other site 856793001655 G5 box; other site 856793001656 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 856793001657 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 856793001658 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 856793001659 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 856793001660 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 856793001661 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 856793001662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793001663 S-adenosylmethionine binding site [chemical binding]; other site 856793001664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001665 Response regulator receiver domain; Region: Response_reg; pfam00072 856793001666 active site 856793001667 phosphorylation site [posttranslational modification] 856793001668 intermolecular recognition site; other site 856793001669 dimerization interface [polypeptide binding]; other site 856793001670 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 856793001671 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 856793001672 active site 856793001673 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 856793001674 substrate binding site [chemical binding]; other site 856793001675 metal binding site [ion binding]; metal-binding site 856793001676 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 856793001677 active site 856793001678 tetramer interface; other site 856793001679 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 856793001680 HSP70 interaction site [polypeptide binding]; other site 856793001681 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 856793001682 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 856793001683 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 856793001684 active site 856793001685 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 856793001686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 856793001687 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 856793001688 nucleophilic elbow; other site 856793001689 catalytic triad; other site 856793001690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 856793001691 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 856793001692 Walker A/P-loop; other site 856793001693 ATP binding site [chemical binding]; other site 856793001694 Q-loop/lid; other site 856793001695 ABC transporter signature motif; other site 856793001696 Walker B; other site 856793001697 D-loop; other site 856793001698 H-loop/switch region; other site 856793001699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 856793001700 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 856793001701 Walker A/P-loop; other site 856793001702 ATP binding site [chemical binding]; other site 856793001703 Q-loop/lid; other site 856793001704 ABC transporter signature motif; other site 856793001705 Walker B; other site 856793001706 D-loop; other site 856793001707 H-loop/switch region; other site 856793001708 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 856793001709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 856793001710 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 856793001711 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 856793001712 metal binding site [ion binding]; metal-binding site 856793001713 putative dimer interface [polypeptide binding]; other site 856793001714 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 856793001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 856793001716 dimer interface [polypeptide binding]; other site 856793001717 conserved gate region; other site 856793001718 putative PBP binding loops; other site 856793001719 ABC-ATPase subunit interface; other site 856793001720 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 856793001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 856793001722 dimer interface [polypeptide binding]; other site 856793001723 conserved gate region; other site 856793001724 ABC-ATPase subunit interface; other site 856793001725 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 856793001726 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 856793001727 Zn binding site [ion binding]; other site 856793001728 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 856793001729 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793001730 catalytic core [active] 856793001731 O-Antigen ligase; Region: Wzy_C; pfam04932 856793001732 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 856793001733 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 856793001734 active site 856793001735 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 856793001736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 856793001737 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793001738 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 856793001739 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 856793001740 quinone interaction residues [chemical binding]; other site 856793001741 active site 856793001742 catalytic residues [active] 856793001743 FMN binding site [chemical binding]; other site 856793001744 substrate binding site [chemical binding]; other site 856793001745 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 856793001746 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 856793001747 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 856793001748 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 856793001749 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 856793001750 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 856793001751 putative catalytic site [active] 856793001752 putative metal binding site [ion binding]; other site 856793001753 putative phosphate binding site [ion binding]; other site 856793001754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793001755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001756 active site 856793001757 phosphorylation site [posttranslational modification] 856793001758 intermolecular recognition site; other site 856793001759 dimerization interface [polypeptide binding]; other site 856793001760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793001761 DNA binding site [nucleotide binding] 856793001762 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 856793001763 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 856793001764 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 856793001765 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 856793001766 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 856793001767 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 856793001768 Walker A motif/ATP binding site; other site 856793001769 Walker B motif; other site 856793001770 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 856793001771 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 856793001772 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 856793001773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 856793001774 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 856793001775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 856793001776 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 856793001777 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 856793001778 FHIPEP family; Region: FHIPEP; pfam00771 856793001779 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 856793001780 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793001781 ligand binding site [chemical binding]; other site 856793001782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001783 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 856793001784 active site 856793001785 phosphorylation site [posttranslational modification] 856793001786 intermolecular recognition site; other site 856793001787 dimerization interface [polypeptide binding]; other site 856793001788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793001789 Walker A motif; other site 856793001790 ATP binding site [chemical binding]; other site 856793001791 Walker B motif; other site 856793001792 arginine finger; other site 856793001793 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 856793001794 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 856793001795 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 856793001796 flagellar motor switch protein; Reviewed; Region: PRK08916 856793001797 flagellar assembly protein H; Validated; Region: fliH; PRK06032 856793001798 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 856793001799 FliG C-terminal domain; Region: FliG_C; pfam01706 856793001800 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 856793001801 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 856793001802 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 856793001803 FlaG protein; Region: FlaG; cl00591 856793001804 Flagellar protein FlaF; Region: FlaF; cl11454 856793001805 Flagellar protein FlbT; Region: FlbT; pfam07378 856793001806 flagellin; Reviewed; Region: PRK12688 856793001807 flagellin; Reviewed; Region: PRK12688 856793001808 pyruvate phosphate dikinase; Provisional; Region: PRK09279 856793001809 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 856793001810 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 856793001811 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 856793001812 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 856793001813 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 856793001814 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 856793001815 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 856793001816 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 856793001817 putative active site [active] 856793001818 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 856793001819 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 856793001820 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 856793001821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 856793001822 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 856793001823 substrate binding site [chemical binding]; other site 856793001824 ATP binding site [chemical binding]; other site 856793001825 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 856793001826 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 856793001827 substrate-cofactor binding pocket; other site 856793001828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793001829 catalytic residue [active] 856793001830 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 856793001831 substrate binding site [chemical binding]; other site 856793001832 dimer interface [polypeptide binding]; other site 856793001833 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 856793001834 ATP binding site [chemical binding]; other site 856793001835 Response regulator receiver domain; Region: Response_reg; pfam00072 856793001836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793001837 active site 856793001838 phosphorylation site [posttranslational modification] 856793001839 intermolecular recognition site; other site 856793001840 dimerization interface [polypeptide binding]; other site 856793001841 thiamine pyrophosphate protein; Validated; Region: PRK08199 856793001842 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 856793001843 PYR/PP interface [polypeptide binding]; other site 856793001844 dimer interface [polypeptide binding]; other site 856793001845 TPP binding site [chemical binding]; other site 856793001846 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 856793001847 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 856793001848 TPP-binding site [chemical binding]; other site 856793001849 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 856793001850 aromatic arch; other site 856793001851 DCoH dimer interaction site [polypeptide binding]; other site 856793001852 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 856793001853 DCoH tetramer interaction site [polypeptide binding]; other site 856793001854 substrate binding site [chemical binding]; other site 856793001855 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 856793001856 heat shock protein 90; Provisional; Region: PRK05218 856793001857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793001858 ATP binding site [chemical binding]; other site 856793001859 Mg2+ binding site [ion binding]; other site 856793001860 G-X-G motif; other site 856793001861 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 856793001862 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 856793001863 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 856793001864 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 856793001865 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 856793001866 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 856793001867 NAD binding site [chemical binding]; other site 856793001868 homotetramer interface [polypeptide binding]; other site 856793001869 homodimer interface [polypeptide binding]; other site 856793001870 substrate binding site [chemical binding]; other site 856793001871 active site 856793001872 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 856793001873 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 856793001874 Tetramer interface [polypeptide binding]; other site 856793001875 active site 856793001876 FMN-binding site [chemical binding]; other site 856793001877 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 856793001878 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 856793001879 tandem repeat interface [polypeptide binding]; other site 856793001880 oligomer interface [polypeptide binding]; other site 856793001881 active site residues [active] 856793001882 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 856793001883 tandem repeat interface [polypeptide binding]; other site 856793001884 oligomer interface [polypeptide binding]; other site 856793001885 active site residues [active] 856793001886 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 856793001887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793001888 motif II; other site 856793001889 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 856793001890 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 856793001891 TPP-binding site; other site 856793001892 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 856793001893 PYR/PP interface [polypeptide binding]; other site 856793001894 dimer interface [polypeptide binding]; other site 856793001895 TPP binding site [chemical binding]; other site 856793001896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 856793001897 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 856793001898 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 856793001899 substrate binding pocket [chemical binding]; other site 856793001900 chain length determination region; other site 856793001901 substrate-Mg2+ binding site; other site 856793001902 catalytic residues [active] 856793001903 aspartate-rich region 1; other site 856793001904 active site lid residues [active] 856793001905 aspartate-rich region 2; other site 856793001906 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 856793001907 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 856793001908 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 856793001909 putative active site [active] 856793001910 Zn binding site [ion binding]; other site 856793001911 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 856793001912 dimerization interface [polypeptide binding]; other site 856793001913 putative active cleft [active] 856793001914 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 856793001915 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 856793001916 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 856793001917 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 856793001918 putative active site [active] 856793001919 putative substrate binding site [chemical binding]; other site 856793001920 ATP binding site [chemical binding]; other site 856793001921 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 856793001922 RNA/DNA hybrid binding site [nucleotide binding]; other site 856793001923 active site 856793001924 Transglycosylase; Region: Transgly; pfam00912 856793001925 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 856793001926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 856793001927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 856793001928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 856793001929 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 856793001930 MgtE intracellular N domain; Region: MgtE_N; pfam03448 856793001931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 856793001932 Divalent cation transporter; Region: MgtE; pfam01769 856793001933 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 856793001934 Malic enzyme, N-terminal domain; Region: malic; pfam00390 856793001935 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 856793001936 putative NAD(P) binding site [chemical binding]; other site 856793001937 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 856793001938 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 856793001939 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 856793001940 seryl-tRNA synthetase; Provisional; Region: PRK05431 856793001941 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 856793001942 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 856793001943 dimer interface [polypeptide binding]; other site 856793001944 active site 856793001945 motif 1; other site 856793001946 motif 2; other site 856793001947 motif 3; other site 856793001948 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 856793001949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793001950 S-adenosylmethionine binding site [chemical binding]; other site 856793001951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 856793001952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 856793001953 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 856793001954 Peptidase family M23; Region: Peptidase_M23; pfam01551 856793001955 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 856793001956 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 856793001957 Preprotein translocase subunit; Region: YajC; pfam02699 856793001958 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 856793001959 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 856793001960 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 856793001961 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 856793001962 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 856793001963 Protein export membrane protein; Region: SecD_SecF; pfam02355 856793001964 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 856793001965 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 856793001966 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 856793001967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 856793001968 active site 856793001969 metal binding site [ion binding]; metal-binding site 856793001970 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 856793001971 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 856793001972 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 856793001973 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 856793001974 aspartate-rich region 1; other site 856793001975 FecR protein; Region: FecR; pfam04773 856793001976 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 856793001977 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 856793001978 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 856793001979 NHL repeat; Region: NHL; pfam01436 856793001980 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 856793001981 Glucose inhibited division protein A; Region: GIDA; pfam01134 856793001982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 856793001983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793001984 Coenzyme A binding pocket [chemical binding]; other site 856793001985 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 856793001986 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 856793001987 Y-family of DNA polymerases; Region: PolY; cd00424 856793001988 active site 856793001989 DNA binding site [nucleotide binding] 856793001990 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 856793001991 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 856793001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 856793001993 tellurium resistance terB-like protein; Region: terB_like; cd07177 856793001994 metal binding site [ion binding]; metal-binding site 856793001995 Type IV pili component [Cell motility and secretion]; Region: COG5461 856793001996 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 856793001997 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 856793001998 acyl-activating enzyme (AAE) consensus motif; other site 856793001999 putative AMP binding site [chemical binding]; other site 856793002000 putative active site [active] 856793002001 putative CoA binding site [chemical binding]; other site 856793002002 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 856793002003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002005 dimer interface [polypeptide binding]; other site 856793002006 phosphorylation site [posttranslational modification] 856793002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002008 ATP binding site [chemical binding]; other site 856793002009 Mg2+ binding site [ion binding]; other site 856793002010 G-X-G motif; other site 856793002011 Response regulator receiver domain; Region: Response_reg; pfam00072 856793002012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002013 active site 856793002014 phosphorylation site [posttranslational modification] 856793002015 intermolecular recognition site; other site 856793002016 dimerization interface [polypeptide binding]; other site 856793002017 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 856793002018 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 856793002019 dimer interface [polypeptide binding]; other site 856793002020 active site 856793002021 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 856793002022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 856793002023 active site 856793002024 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 856793002025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793002026 NAD(P) binding site [chemical binding]; other site 856793002027 active site 856793002028 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 856793002029 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 856793002030 tetramer interface [polypeptide binding]; other site 856793002031 active site 856793002032 Mg2+/Mn2+ binding site [ion binding]; other site 856793002033 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 856793002034 dimer interface [polypeptide binding]; other site 856793002035 Citrate synthase; Region: Citrate_synt; pfam00285 856793002036 active site 856793002037 citrylCoA binding site [chemical binding]; other site 856793002038 oxalacetate/citrate binding site [chemical binding]; other site 856793002039 coenzyme A binding site [chemical binding]; other site 856793002040 catalytic triad [active] 856793002041 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 856793002042 GIY-YIG motif/motif A; other site 856793002043 putative active site [active] 856793002044 putative metal binding site [ion binding]; other site 856793002045 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 856793002046 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 856793002047 2-methylcitrate dehydratase; Region: prpD; TIGR02330 856793002048 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 856793002049 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 856793002050 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 856793002051 active site 856793002052 catalytic site [active] 856793002053 CAAX protease self-immunity; Region: Abi; pfam02517 856793002054 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 856793002055 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 856793002056 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 856793002057 dimer interface [polypeptide binding]; other site 856793002058 active site 856793002059 CoA binding pocket [chemical binding]; other site 856793002060 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 856793002061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 856793002062 active site 856793002063 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 856793002064 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 856793002065 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 856793002066 enoyl-CoA hydratase; Provisional; Region: PRK05995 856793002067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 856793002068 substrate binding site [chemical binding]; other site 856793002069 oxyanion hole (OAH) forming residues; other site 856793002070 trimer interface [polypeptide binding]; other site 856793002071 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 856793002072 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 856793002073 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 856793002074 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 856793002075 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 856793002076 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 856793002077 carboxyltransferase (CT) interaction site; other site 856793002078 biotinylation site [posttranslational modification]; other site 856793002079 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 856793002080 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 856793002081 active site 856793002082 catalytic residues [active] 856793002083 metal binding site [ion binding]; metal-binding site 856793002084 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 856793002085 isovaleryl-CoA dehydrogenase; Region: PLN02519 856793002086 substrate binding site [chemical binding]; other site 856793002087 FAD binding site [chemical binding]; other site 856793002088 catalytic base [active] 856793002089 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 856793002090 ArsC family; Region: ArsC; pfam03960 856793002091 putative catalytic residues [active] 856793002092 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 856793002093 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 856793002094 dimer interface [polypeptide binding]; other site 856793002095 PYR/PP interface [polypeptide binding]; other site 856793002096 TPP binding site [chemical binding]; other site 856793002097 substrate binding site [chemical binding]; other site 856793002098 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 856793002099 TPP-binding site [chemical binding]; other site 856793002100 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 856793002101 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 856793002102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793002103 Walker A/P-loop; other site 856793002104 ATP binding site [chemical binding]; other site 856793002105 Q-loop/lid; other site 856793002106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793002107 ABC transporter signature motif; other site 856793002108 Walker B; other site 856793002109 D-loop; other site 856793002110 H-loop/switch region; other site 856793002111 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 856793002112 CoenzymeA binding site [chemical binding]; other site 856793002113 subunit interaction site [polypeptide binding]; other site 856793002114 PHB binding site; other site 856793002115 Methyltransferase domain; Region: Methyltransf_23; pfam13489 856793002116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002117 S-adenosylmethionine binding site [chemical binding]; other site 856793002118 ABC transporter ATPase component; Reviewed; Region: PRK11147 856793002119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793002120 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793002121 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 856793002122 IHF dimer interface [polypeptide binding]; other site 856793002123 IHF - DNA interface [nucleotide binding]; other site 856793002124 MASE1; Region: MASE1; pfam05231 856793002125 CHASE domain; Region: CHASE; pfam03924 856793002126 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 856793002127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793002128 putative active site [active] 856793002129 heme pocket [chemical binding]; other site 856793002130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002131 dimer interface [polypeptide binding]; other site 856793002132 phosphorylation site [posttranslational modification] 856793002133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002134 ATP binding site [chemical binding]; other site 856793002135 Mg2+ binding site [ion binding]; other site 856793002136 G-X-G motif; other site 856793002137 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793002138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002139 active site 856793002140 phosphorylation site [posttranslational modification] 856793002141 intermolecular recognition site; other site 856793002142 dimerization interface [polypeptide binding]; other site 856793002143 Response regulator receiver domain; Region: Response_reg; pfam00072 856793002144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002145 active site 856793002146 phosphorylation site [posttranslational modification] 856793002147 intermolecular recognition site; other site 856793002148 dimerization interface [polypeptide binding]; other site 856793002149 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 856793002150 putative binding surface; other site 856793002151 active site 856793002152 von Willebrand factor type A domain; Region: VWA_2; pfam13519 856793002153 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 856793002154 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 856793002155 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 856793002156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 856793002157 phosphate binding site [ion binding]; other site 856793002158 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 856793002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793002160 ATP binding site [chemical binding]; other site 856793002161 putative Mg++ binding site [ion binding]; other site 856793002162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793002163 nucleotide binding region [chemical binding]; other site 856793002164 ATP-binding site [chemical binding]; other site 856793002165 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 856793002166 HRDC domain; Region: HRDC; pfam00570 856793002167 Methyltransferase domain; Region: Methyltransf_31; pfam13847 856793002168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002169 S-adenosylmethionine binding site [chemical binding]; other site 856793002170 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 856793002171 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 856793002172 dimer interface [polypeptide binding]; other site 856793002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793002174 catalytic residue [active] 856793002175 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 856793002176 MutS domain I; Region: MutS_I; pfam01624 856793002177 MutS domain II; Region: MutS_II; pfam05188 856793002178 MutS domain III; Region: MutS_III; pfam05192 856793002179 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 856793002180 Walker A/P-loop; other site 856793002181 ATP binding site [chemical binding]; other site 856793002182 Q-loop/lid; other site 856793002183 ABC transporter signature motif; other site 856793002184 Walker B; other site 856793002185 D-loop; other site 856793002186 H-loop/switch region; other site 856793002187 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 856793002188 trimer interface [polypeptide binding]; other site 856793002189 active site 856793002190 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 856793002191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002192 S-adenosylmethionine binding site [chemical binding]; other site 856793002193 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 856793002194 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 856793002195 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 856793002196 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 856793002197 active site 856793002198 HIGH motif; other site 856793002199 dimer interface [polypeptide binding]; other site 856793002200 KMSKS motif; other site 856793002201 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 856793002202 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 856793002203 Universal stress protein family; Region: Usp; pfam00582 856793002204 Ligand Binding Site [chemical binding]; other site 856793002205 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 856793002206 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 856793002207 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 856793002208 putative active site [active] 856793002209 putative metal binding site [ion binding]; other site 856793002210 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 856793002211 putative FMN binding site [chemical binding]; other site 856793002212 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 856793002213 Glycoprotease family; Region: Peptidase_M22; pfam00814 856793002214 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 856793002215 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 856793002216 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 856793002217 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 856793002218 Membrane fusogenic activity; Region: BMFP; pfam04380 856793002219 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 856793002220 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 856793002221 NADP binding site [chemical binding]; other site 856793002222 homopentamer interface [polypeptide binding]; other site 856793002223 substrate binding site [chemical binding]; other site 856793002224 active site 856793002225 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 856793002226 Uncharacterized conserved protein [Function unknown]; Region: COG1565 856793002227 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 856793002228 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 856793002229 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 856793002230 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 856793002231 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793002232 active site 856793002233 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 856793002234 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 856793002235 5S rRNA interface [nucleotide binding]; other site 856793002236 CTC domain interface [polypeptide binding]; other site 856793002237 L16 interface [polypeptide binding]; other site 856793002238 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 856793002239 putative active site [active] 856793002240 catalytic residue [active] 856793002241 GTP-binding protein YchF; Reviewed; Region: PRK09601 856793002242 YchF GTPase; Region: YchF; cd01900 856793002243 G1 box; other site 856793002244 GTP/Mg2+ binding site [chemical binding]; other site 856793002245 Switch I region; other site 856793002246 G2 box; other site 856793002247 Switch II region; other site 856793002248 G3 box; other site 856793002249 G4 box; other site 856793002250 G5 box; other site 856793002251 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 856793002252 adenosine deaminase; Provisional; Region: PRK09358 856793002253 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 856793002254 active site 856793002255 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 856793002256 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 856793002257 homodimer interface [polypeptide binding]; other site 856793002258 substrate-cofactor binding pocket; other site 856793002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793002260 catalytic residue [active] 856793002261 osmolarity response regulator; Provisional; Region: ompR; PRK09468 856793002262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002263 active site 856793002264 phosphorylation site [posttranslational modification] 856793002265 intermolecular recognition site; other site 856793002266 dimerization interface [polypeptide binding]; other site 856793002267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793002268 DNA binding site [nucleotide binding] 856793002269 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 856793002270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 856793002271 dimerization interface [polypeptide binding]; other site 856793002272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002273 dimer interface [polypeptide binding]; other site 856793002274 phosphorylation site [posttranslational modification] 856793002275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002276 ATP binding site [chemical binding]; other site 856793002277 Mg2+ binding site [ion binding]; other site 856793002278 G-X-G motif; other site 856793002279 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 856793002280 dimer interface [polypeptide binding]; other site 856793002281 putative tRNA-binding site [nucleotide binding]; other site 856793002282 Phasin protein; Region: Phasin_2; pfam09361 856793002283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793002284 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 856793002285 putative active site [active] 856793002286 heme pocket [chemical binding]; other site 856793002287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793002288 putative active site [active] 856793002289 heme pocket [chemical binding]; other site 856793002290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793002291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002292 dimer interface [polypeptide binding]; other site 856793002293 phosphorylation site [posttranslational modification] 856793002294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002295 ATP binding site [chemical binding]; other site 856793002296 Mg2+ binding site [ion binding]; other site 856793002297 G-X-G motif; other site 856793002298 RecX family; Region: RecX; pfam02631 856793002299 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 856793002300 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 856793002301 dimerization interface [polypeptide binding]; other site 856793002302 domain crossover interface; other site 856793002303 redox-dependent activation switch; other site 856793002304 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 856793002305 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 856793002306 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 856793002307 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793002308 ligand binding site [chemical binding]; other site 856793002309 intracellular protease, PfpI family; Region: PfpI; TIGR01382 856793002310 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 856793002311 conserved cys residue [active] 856793002312 peptide chain release factor 2; Provisional; Region: PRK07342 856793002313 This domain is found in peptide chain release factors; Region: PCRF; smart00937 856793002314 RF-1 domain; Region: RF-1; pfam00472 856793002315 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 856793002316 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 856793002317 seryl-tRNA synthetase; Region: serS; TIGR00414 856793002318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793002319 metal binding site [ion binding]; metal-binding site 856793002320 active site 856793002321 I-site; other site 856793002322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793002323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 856793002324 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 856793002325 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 856793002326 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 856793002327 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 856793002328 putative acyltransferase; Provisional; Region: PRK05790 856793002329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 856793002330 dimer interface [polypeptide binding]; other site 856793002331 active site 856793002332 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 856793002333 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 856793002334 NAD(P) binding site [chemical binding]; other site 856793002335 homotetramer interface [polypeptide binding]; other site 856793002336 homodimer interface [polypeptide binding]; other site 856793002337 active site 856793002338 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 856793002339 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 856793002340 ligand binding site [chemical binding]; other site 856793002341 flexible hinge region; other site 856793002342 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 856793002343 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 856793002344 fumarate hydratase; Reviewed; Region: fumC; PRK00485 856793002345 Class II fumarases; Region: Fumarase_classII; cd01362 856793002346 active site 856793002347 tetramer interface [polypeptide binding]; other site 856793002348 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 856793002349 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 856793002350 active site 856793002351 ADP/pyrophosphate binding site [chemical binding]; other site 856793002352 dimerization interface [polypeptide binding]; other site 856793002353 allosteric effector site; other site 856793002354 fructose-1,6-bisphosphate binding site; other site 856793002355 Bacterial PH domain; Region: DUF304; cl01348 856793002356 murein L,D-transpeptidase; Provisional; Region: PRK10594 856793002357 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793002358 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 856793002359 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 856793002360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 856793002361 Peptidase M15; Region: Peptidase_M15_3; cl01194 856793002362 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 856793002363 Recombination protein O N terminal; Region: RecO_N; pfam11967 856793002364 Recombination protein O C terminal; Region: RecO_C; pfam02565 856793002365 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 856793002366 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 856793002367 CAP-like domain; other site 856793002368 active site 856793002369 primary dimer interface [polypeptide binding]; other site 856793002370 flagellar motor protein MotB; Validated; Region: motB; PRK09041 856793002371 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 856793002372 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793002373 ligand binding site [chemical binding]; other site 856793002374 flagellar motor protein MotA; Validated; Region: PRK09110 856793002375 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 856793002376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 856793002377 putative active site [active] 856793002378 heme pocket [chemical binding]; other site 856793002379 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793002380 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 856793002381 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 856793002382 substrate binding site [chemical binding]; other site 856793002383 oxyanion hole (OAH) forming residues; other site 856793002384 trimer interface [polypeptide binding]; other site 856793002385 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 856793002386 Transcriptional regulators [Transcription]; Region: MarR; COG1846 856793002387 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 856793002388 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 856793002389 DNA methylase; Region: N6_N4_Mtase; pfam01555 856793002390 SseB protein; Region: SseB; cl06279 856793002391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 856793002392 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 856793002393 FAD binding site [chemical binding]; other site 856793002394 substrate binding pocket [chemical binding]; other site 856793002395 catalytic base [active] 856793002396 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 856793002397 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 856793002398 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 856793002399 dimer interface [polypeptide binding]; other site 856793002400 active site 856793002401 glycine-pyridoxal phosphate binding site [chemical binding]; other site 856793002402 folate binding site [chemical binding]; other site 856793002403 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 856793002404 ATP cone domain; Region: ATP-cone; pfam03477 856793002405 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 856793002406 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 856793002407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793002408 NAD(P) binding site [chemical binding]; other site 856793002409 active site 856793002410 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 856793002411 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 856793002412 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 856793002413 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 856793002414 TRAM domain; Region: TRAM; pfam01938 856793002415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002416 S-adenosylmethionine binding site [chemical binding]; other site 856793002417 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 856793002418 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 856793002419 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 856793002420 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 856793002421 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 856793002422 putative phosphate acyltransferase; Provisional; Region: PRK05331 856793002423 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 856793002424 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 856793002425 dimer interface [polypeptide binding]; other site 856793002426 active site 856793002427 CoA binding pocket [chemical binding]; other site 856793002428 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 856793002429 IHF dimer interface [polypeptide binding]; other site 856793002430 IHF - DNA interface [nucleotide binding]; other site 856793002431 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 856793002432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 856793002433 DNA binding residues [nucleotide binding] 856793002434 Predicted dehydrogenase [General function prediction only]; Region: COG0579 856793002435 hydroxyglutarate oxidase; Provisional; Region: PRK11728 856793002436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 856793002437 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 856793002438 transcriptional activator RfaH; Region: RfaH; TIGR01955 856793002439 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 856793002440 heterodimer interface [polypeptide binding]; other site 856793002441 homodimer interface [polypeptide binding]; other site 856793002442 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 856793002443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793002444 NAD(P) binding site [chemical binding]; other site 856793002445 active site 856793002446 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 856793002447 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 856793002448 inhibitor-cofactor binding pocket; inhibition site 856793002449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793002450 catalytic residue [active] 856793002451 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 856793002452 active site 856793002453 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 856793002454 dimer interface [polypeptide binding]; other site 856793002455 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 856793002456 Ligand Binding Site [chemical binding]; other site 856793002457 Molecular Tunnel; other site 856793002458 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 856793002459 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 856793002460 active site 856793002461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002462 S-adenosylmethionine binding site [chemical binding]; other site 856793002463 hypothetical protein; Provisional; Region: PRK05849 856793002464 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 856793002465 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 856793002466 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 856793002467 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 856793002468 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 856793002469 active site 856793002470 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 856793002471 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 856793002472 active site 856793002473 metal-binding site 856793002474 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 856793002475 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 856793002476 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 856793002477 active site 856793002478 substrate binding site [chemical binding]; other site 856793002479 cosubstrate binding site; other site 856793002480 catalytic site [active] 856793002481 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 856793002482 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 856793002483 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 856793002484 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 856793002485 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 856793002486 extended (e) SDRs; Region: SDR_e; cd08946 856793002487 NAD(P) binding site [chemical binding]; other site 856793002488 active site 856793002489 substrate binding site [chemical binding]; other site 856793002490 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793002491 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 856793002492 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 856793002493 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 856793002494 active site 856793002495 dimer interface [polypeptide binding]; other site 856793002496 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 856793002497 Ligand Binding Site [chemical binding]; other site 856793002498 Molecular Tunnel; other site 856793002499 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 856793002500 active site 856793002501 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 856793002502 homodimer interface [polypeptide binding]; other site 856793002503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 856793002504 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 856793002505 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 856793002506 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 856793002507 homodimer interface [polypeptide binding]; other site 856793002508 substrate-cofactor binding pocket; other site 856793002509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793002510 catalytic residue [active] 856793002511 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 856793002512 23S rRNA interface [nucleotide binding]; other site 856793002513 L3 interface [polypeptide binding]; other site 856793002514 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 856793002515 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 856793002516 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 856793002517 trimer interface [polypeptide binding]; other site 856793002518 putative metal binding site [ion binding]; other site 856793002519 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 856793002520 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 856793002521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 856793002522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793002523 metal binding site [ion binding]; metal-binding site 856793002524 active site 856793002525 I-site; other site 856793002526 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 856793002527 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793002528 ligand binding site [chemical binding]; other site 856793002529 homoserine dehydrogenase; Provisional; Region: PRK06349 856793002530 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 856793002531 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 856793002532 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 856793002533 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 856793002534 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 856793002535 putative active site [active] 856793002536 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 856793002537 DHH family; Region: DHH; pfam01368 856793002538 DHHA1 domain; Region: DHHA1; pfam02272 856793002539 putative cation:proton antiport protein; Provisional; Region: PRK10669 856793002540 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 856793002541 TrkA-N domain; Region: TrkA_N; pfam02254 856793002542 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 856793002543 Uncharacterized conserved protein [Function unknown]; Region: COG2128 856793002544 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793002545 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 856793002546 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 856793002547 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 856793002548 GatB domain; Region: GatB_Yqey; smart00845 856793002549 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 856793002550 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 856793002551 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 856793002552 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 856793002553 Protein of unknown function DUF45; Region: DUF45; pfam01863 856793002554 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 856793002555 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 856793002556 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 856793002557 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 856793002558 substrate binding site [chemical binding]; other site 856793002559 ATP binding site [chemical binding]; other site 856793002560 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 856793002561 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 856793002562 CobD/Cbib protein; Region: CobD_Cbib; cl00561 856793002563 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 856793002564 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 856793002565 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 856793002566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793002567 metal binding site [ion binding]; metal-binding site 856793002568 active site 856793002569 I-site; other site 856793002570 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 856793002571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793002572 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 856793002573 putative active site [active] 856793002574 heme pocket [chemical binding]; other site 856793002575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002576 dimer interface [polypeptide binding]; other site 856793002577 phosphorylation site [posttranslational modification] 856793002578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002579 ATP binding site [chemical binding]; other site 856793002580 Mg2+ binding site [ion binding]; other site 856793002581 G-X-G motif; other site 856793002582 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 856793002583 metal binding site 2 [ion binding]; metal-binding site 856793002584 putative DNA binding helix; other site 856793002585 metal binding site 1 [ion binding]; metal-binding site 856793002586 dimer interface [polypeptide binding]; other site 856793002587 structural Zn2+ binding site [ion binding]; other site 856793002588 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 856793002589 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 856793002590 dimer interface [polypeptide binding]; other site 856793002591 substrate binding site [chemical binding]; other site 856793002592 metal binding sites [ion binding]; metal-binding site 856793002593 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 856793002594 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 856793002595 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 856793002596 G1 box; other site 856793002597 putative GEF interaction site [polypeptide binding]; other site 856793002598 GTP/Mg2+ binding site [chemical binding]; other site 856793002599 Switch I region; other site 856793002600 G2 box; other site 856793002601 G3 box; other site 856793002602 Switch II region; other site 856793002603 G4 box; other site 856793002604 G5 box; other site 856793002605 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 856793002606 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 856793002607 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 856793002608 Transcriptional regulator; Region: Rrf2; pfam02082 856793002609 Transcriptional regulator; Region: Rrf2; cl17282 856793002610 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 856793002611 putative ABC transporter; Region: ycf24; CHL00085 856793002612 FeS assembly ATPase SufC; Region: sufC; TIGR01978 856793002613 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 856793002614 Walker A/P-loop; other site 856793002615 ATP binding site [chemical binding]; other site 856793002616 Q-loop/lid; other site 856793002617 ABC transporter signature motif; other site 856793002618 Walker B; other site 856793002619 D-loop; other site 856793002620 H-loop/switch region; other site 856793002621 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 856793002622 GIY-YIG motif/motif A; other site 856793002623 putative active site [active] 856793002624 putative metal binding site [ion binding]; other site 856793002625 FeS assembly protein SufD; Region: sufD; TIGR01981 856793002626 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 856793002627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 856793002628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 856793002629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793002630 catalytic residue [active] 856793002631 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 856793002632 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 856793002633 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 856793002634 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 856793002635 FMN binding site [chemical binding]; other site 856793002636 active site 856793002637 catalytic residues [active] 856793002638 substrate binding site [chemical binding]; other site 856793002639 Bacterial SH3 domain; Region: SH3_4; pfam06347 856793002640 Bacterial SH3 domain; Region: SH3_4; pfam06347 856793002641 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 856793002642 active site 1 [active] 856793002643 dimer interface [polypeptide binding]; other site 856793002644 active site 2 [active] 856793002645 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 856793002646 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 856793002647 dimer interface [polypeptide binding]; other site 856793002648 active site 856793002649 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 856793002650 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 856793002651 NAD binding site [chemical binding]; other site 856793002652 homotetramer interface [polypeptide binding]; other site 856793002653 homodimer interface [polypeptide binding]; other site 856793002654 substrate binding site [chemical binding]; other site 856793002655 active site 856793002656 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 856793002657 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 856793002658 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 856793002659 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 856793002660 putative active site [active] 856793002661 catalytic site [active] 856793002662 putative metal binding site [ion binding]; other site 856793002663 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 856793002664 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 856793002665 RNase E interface [polypeptide binding]; other site 856793002666 trimer interface [polypeptide binding]; other site 856793002667 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 856793002668 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 856793002669 RNase E interface [polypeptide binding]; other site 856793002670 trimer interface [polypeptide binding]; other site 856793002671 active site 856793002672 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 856793002673 putative nucleic acid binding region [nucleotide binding]; other site 856793002674 G-X-X-G motif; other site 856793002675 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 856793002676 RNA binding site [nucleotide binding]; other site 856793002677 domain interface; other site 856793002678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793002679 catalytic core [active] 856793002680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 856793002681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 856793002682 active site 856793002683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 856793002684 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 856793002685 16S/18S rRNA binding site [nucleotide binding]; other site 856793002686 S13e-L30e interaction site [polypeptide binding]; other site 856793002687 25S rRNA binding site [nucleotide binding]; other site 856793002688 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 856793002689 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 856793002690 RNA binding site [nucleotide binding]; other site 856793002691 active site 856793002692 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 856793002693 translation initiation factor IF-2; Region: IF-2; TIGR00487 856793002694 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 856793002695 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 856793002696 G1 box; other site 856793002697 putative GEF interaction site [polypeptide binding]; other site 856793002698 GTP/Mg2+ binding site [chemical binding]; other site 856793002699 Switch I region; other site 856793002700 G2 box; other site 856793002701 G3 box; other site 856793002702 Switch II region; other site 856793002703 G4 box; other site 856793002704 G5 box; other site 856793002705 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 856793002706 Translation-initiation factor 2; Region: IF-2; pfam11987 856793002707 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 856793002708 Protein of unknown function (DUF448); Region: DUF448; pfam04296 856793002709 putative RNA binding cleft [nucleotide binding]; other site 856793002710 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 856793002711 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 856793002712 NusA N-terminal domain; Region: NusA_N; pfam08529 856793002713 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 856793002714 RNA binding site [nucleotide binding]; other site 856793002715 homodimer interface [polypeptide binding]; other site 856793002716 NusA-like KH domain; Region: KH_5; pfam13184 856793002717 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 856793002718 G-X-X-G motif; other site 856793002719 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 856793002720 ribosome maturation protein RimP; Reviewed; Region: PRK00092 856793002721 Sm and related proteins; Region: Sm_like; cl00259 856793002722 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 856793002723 putative oligomer interface [polypeptide binding]; other site 856793002724 putative RNA binding site [nucleotide binding]; other site 856793002725 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 856793002726 S-adenosylmethionine synthetase; Validated; Region: PRK05250 856793002727 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 856793002728 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 856793002729 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 856793002730 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 856793002731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793002732 non-specific DNA binding site [nucleotide binding]; other site 856793002733 salt bridge; other site 856793002734 sequence-specific DNA binding site [nucleotide binding]; other site 856793002735 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 856793002736 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 856793002737 putative active site [active] 856793002738 catalytic triad [active] 856793002739 putative dimer interface [polypeptide binding]; other site 856793002740 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 856793002741 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 856793002742 Transporter associated domain; Region: CorC_HlyC; pfam03471 856793002743 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 856793002744 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 856793002745 PhoH-like protein; Region: PhoH; pfam02562 856793002746 PhoH-like protein; Region: PhoH; pfam02562 856793002747 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 856793002748 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 856793002749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793002750 FeS/SAM binding site; other site 856793002751 TRAM domain; Region: TRAM; pfam01938 856793002752 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793002753 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 856793002754 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 856793002755 CobD/Cbib protein; Region: CobD_Cbib; cl00561 856793002756 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 856793002757 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 856793002758 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 856793002759 active site 856793002760 trimer interface [polypeptide binding]; other site 856793002761 allosteric site; other site 856793002762 active site lid [active] 856793002763 hexamer (dimer of trimers) interface [polypeptide binding]; other site 856793002764 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 856793002765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793002766 active site 856793002767 motif I; other site 856793002768 motif II; other site 856793002769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793002770 hypothetical protein; Provisional; Region: PRK10279 856793002771 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 856793002772 active site 856793002773 nucleophile elbow; other site 856793002774 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 856793002775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793002776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793002777 Walker A/P-loop; other site 856793002778 ATP binding site [chemical binding]; other site 856793002779 Q-loop/lid; other site 856793002780 ABC transporter signature motif; other site 856793002781 Walker B; other site 856793002782 D-loop; other site 856793002783 H-loop/switch region; other site 856793002784 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 856793002785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 856793002786 FOG: CBS domain [General function prediction only]; Region: COG0517 856793002787 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 856793002788 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 856793002789 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 856793002790 transmembrane helices; other site 856793002791 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 856793002792 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 856793002793 catalytic site [active] 856793002794 metal binding site [ion binding]; metal-binding site 856793002795 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 856793002796 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 856793002797 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 856793002798 active site residue [active] 856793002799 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 856793002800 active site residue [active] 856793002801 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 856793002802 cyclase homology domain; Region: CHD; cd07302 856793002803 nucleotidyl binding site; other site 856793002804 metal binding site [ion binding]; metal-binding site 856793002805 dimer interface [polypeptide binding]; other site 856793002806 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 856793002807 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 856793002808 Chromate transporter; Region: Chromate_transp; pfam02417 856793002809 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 856793002810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793002811 FeS/SAM binding site; other site 856793002812 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 856793002813 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 856793002814 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 856793002815 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 856793002816 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 856793002817 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793002818 active site 856793002819 HIGH motif; other site 856793002820 nucleotide binding site [chemical binding]; other site 856793002821 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 856793002822 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 856793002823 active site 856793002824 KMSKS motif; other site 856793002825 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 856793002826 tRNA binding surface [nucleotide binding]; other site 856793002827 anticodon binding site; other site 856793002828 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 856793002829 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 856793002830 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 856793002831 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 856793002832 active site 856793002833 intersubunit interface [polypeptide binding]; other site 856793002834 zinc binding site [ion binding]; other site 856793002835 Na+ binding site [ion binding]; other site 856793002836 MarR family; Region: MarR; pfam01047 856793002837 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 856793002838 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 856793002839 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 856793002840 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 856793002841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793002842 S-adenosylmethionine binding site [chemical binding]; other site 856793002843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 856793002844 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 856793002845 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 856793002846 TPP-binding site [chemical binding]; other site 856793002847 dimer interface [polypeptide binding]; other site 856793002848 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 856793002849 PYR/PP interface [polypeptide binding]; other site 856793002850 dimer interface [polypeptide binding]; other site 856793002851 TPP binding site [chemical binding]; other site 856793002852 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 856793002853 Cell division protein ZapA; Region: ZapA; pfam05164 856793002854 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 856793002855 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 856793002856 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 856793002857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 856793002858 putative active site [active] 856793002859 metal binding site [ion binding]; metal-binding site 856793002860 homodimer binding site [polypeptide binding]; other site 856793002861 Response regulator receiver domain; Region: Response_reg; pfam00072 856793002862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002863 active site 856793002864 phosphorylation site [posttranslational modification] 856793002865 intermolecular recognition site; other site 856793002866 dimerization interface [polypeptide binding]; other site 856793002867 hypothetical protein; Validated; Region: PRK00110 856793002868 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 856793002869 active site 856793002870 putative DNA-binding cleft [nucleotide binding]; other site 856793002871 dimer interface [polypeptide binding]; other site 856793002872 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 856793002873 RuvA N terminal domain; Region: RuvA_N; pfam01330 856793002874 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 856793002875 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 856793002876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793002877 Walker A motif; other site 856793002878 ATP binding site [chemical binding]; other site 856793002879 Walker B motif; other site 856793002880 arginine finger; other site 856793002881 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 856793002882 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 856793002883 active site 856793002884 TolQ protein; Region: tolQ; TIGR02796 856793002885 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 856793002886 TolR protein; Region: tolR; TIGR02801 856793002887 translocation protein TolB; Provisional; Region: tolB; PRK05137 856793002888 TolB amino-terminal domain; Region: TolB_N; pfam04052 856793002889 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 856793002890 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 856793002891 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 856793002892 putative active site [active] 856793002893 Ap4A binding site [chemical binding]; other site 856793002894 nudix motif; other site 856793002895 putative metal binding site [ion binding]; other site 856793002896 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 856793002897 NodB motif; other site 856793002898 putative active site [active] 856793002899 putative catalytic site [active] 856793002900 Zn binding site [ion binding]; other site 856793002901 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 856793002902 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 856793002903 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 856793002904 protein binding site [polypeptide binding]; other site 856793002905 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 856793002906 Catalytic dyad [active] 856793002907 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 856793002908 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 856793002909 Peptidase family M23; Region: Peptidase_M23; pfam01551 856793002910 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 856793002911 Oligomerisation domain; Region: Oligomerisation; pfam02410 856793002912 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 856793002913 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 856793002914 active site 856793002915 (T/H)XGH motif; other site 856793002916 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 856793002917 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 856793002918 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 856793002919 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 856793002920 ATP synthase subunit C; Region: ATP-synt_C; cl00466 856793002921 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 856793002922 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 856793002923 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 856793002924 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 856793002925 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 856793002926 Walker A/P-loop; other site 856793002927 ATP binding site [chemical binding]; other site 856793002928 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 856793002929 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 856793002930 ABC transporter signature motif; other site 856793002931 Walker B; other site 856793002932 D-loop; other site 856793002933 H-loop/switch region; other site 856793002934 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 856793002935 Thioredoxin; Region: Thioredoxin_4; pfam13462 856793002936 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 856793002937 ligand binding site [chemical binding]; other site 856793002938 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 856793002939 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 856793002940 active site 856793002941 dimerization interface [polypeptide binding]; other site 856793002942 Protein of unknown function (DUF721); Region: DUF721; pfam05258 856793002943 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 856793002944 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 856793002945 minor groove reading motif; other site 856793002946 helix-hairpin-helix signature motif; other site 856793002947 substrate binding pocket [chemical binding]; other site 856793002948 active site 856793002949 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 856793002950 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 856793002951 DNA binding and oxoG recognition site [nucleotide binding] 856793002952 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 856793002953 DNA methylase; Region: N6_N4_Mtase; pfam01555 856793002954 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 856793002955 RNA/DNA hybrid binding site [nucleotide binding]; other site 856793002956 active site 856793002957 aminopeptidase N; Provisional; Region: pepN; PRK14015 856793002958 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 856793002959 active site 856793002960 Zn binding site [ion binding]; other site 856793002961 GTPase CgtA; Reviewed; Region: obgE; PRK12299 856793002962 GTP1/OBG; Region: GTP1_OBG; pfam01018 856793002963 Obg GTPase; Region: Obg; cd01898 856793002964 G1 box; other site 856793002965 GTP/Mg2+ binding site [chemical binding]; other site 856793002966 Switch I region; other site 856793002967 G2 box; other site 856793002968 G3 box; other site 856793002969 Switch II region; other site 856793002970 G4 box; other site 856793002971 G5 box; other site 856793002972 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 856793002973 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 856793002974 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 856793002975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793002976 dimer interface [polypeptide binding]; other site 856793002977 phosphorylation site [posttranslational modification] 856793002978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793002979 ATP binding site [chemical binding]; other site 856793002980 Mg2+ binding site [ion binding]; other site 856793002981 G-X-G motif; other site 856793002982 Response regulator receiver domain; Region: Response_reg; pfam00072 856793002983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793002984 active site 856793002985 phosphorylation site [posttranslational modification] 856793002986 intermolecular recognition site; other site 856793002987 dimerization interface [polypeptide binding]; other site 856793002988 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 856793002989 Mechanosensitive ion channel; Region: MS_channel; pfam00924 856793002990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 856793002991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793002993 Walker A/P-loop; other site 856793002994 ATP binding site [chemical binding]; other site 856793002995 Q-loop/lid; other site 856793002996 ABC transporter signature motif; other site 856793002997 Walker B; other site 856793002998 D-loop; other site 856793002999 H-loop/switch region; other site 856793003000 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 856793003001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793003002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793003003 Walker A/P-loop; other site 856793003004 ATP binding site [chemical binding]; other site 856793003005 Q-loop/lid; other site 856793003006 ABC transporter signature motif; other site 856793003007 Walker B; other site 856793003008 D-loop; other site 856793003009 H-loop/switch region; other site 856793003010 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 856793003011 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 856793003012 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793003013 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793003014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793003015 active site 856793003016 phosphorylation site [posttranslational modification] 856793003017 intermolecular recognition site; other site 856793003018 dimerization interface [polypeptide binding]; other site 856793003019 Thioredoxin; Region: Thioredoxin_4; cl17273 856793003020 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 856793003021 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793003022 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 856793003023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 856793003024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 856793003025 active site 856793003026 catalytic tetrad [active] 856793003027 putative transporter; Provisional; Region: PRK11660 856793003028 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 856793003029 Sulfate transporter family; Region: Sulfate_transp; pfam00916 856793003030 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 856793003031 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 856793003032 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 856793003033 active site 856793003034 FMN binding site [chemical binding]; other site 856793003035 substrate binding site [chemical binding]; other site 856793003036 homotetramer interface [polypeptide binding]; other site 856793003037 catalytic residue [active] 856793003038 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 856793003039 metal binding site 2 [ion binding]; metal-binding site 856793003040 putative DNA binding helix; other site 856793003041 metal binding site 1 [ion binding]; metal-binding site 856793003042 dimer interface [polypeptide binding]; other site 856793003043 structural Zn2+ binding site [ion binding]; other site 856793003044 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 856793003045 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 856793003046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793003047 catalytic residue [active] 856793003048 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 856793003049 active site residue [active] 856793003050 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 856793003051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 856793003052 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 856793003053 catalytic residue [active] 856793003054 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 856793003055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 856793003056 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 856793003057 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 856793003058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793003059 catalytic residue [active] 856793003060 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 856793003061 Domain of unknown function DUF20; Region: UPF0118; pfam01594 856793003062 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 856793003063 Peptidase family M48; Region: Peptidase_M48; cl12018 856793003064 arginine:agmatin antiporter; Provisional; Region: PRK10644 856793003065 FOG: CBS domain [General function prediction only]; Region: COG0517 856793003066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 856793003067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793003068 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 856793003069 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 856793003070 active site 856793003071 metal binding site [ion binding]; metal-binding site 856793003072 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 856793003073 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 856793003074 Uncharacterized conserved protein [Function unknown]; Region: COG1479 856793003075 Protein of unknown function DUF262; Region: DUF262; pfam03235 856793003076 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 856793003077 HsdM N-terminal domain; Region: HsdM_N; pfam12161 856793003078 Methyltransferase domain; Region: Methyltransf_26; pfam13659 856793003079 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 856793003080 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 856793003081 Abortive infection C-terminus; Region: Abi_C; pfam14355 856793003082 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 856793003083 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 856793003084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793003085 ATP binding site [chemical binding]; other site 856793003086 putative Mg++ binding site [ion binding]; other site 856793003087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793003088 ATP binding site [chemical binding]; other site 856793003089 Mg2+ binding site [ion binding]; other site 856793003090 G-X-G motif; other site 856793003091 MobA/MobL family; Region: MobA_MobL; pfam03389 856793003092 Translocation protein Sec62; Region: Sec62; cl02170 856793003093 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 856793003094 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 856793003095 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 856793003096 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 856793003097 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 856793003098 Multicopper oxidase; Region: Cu-oxidase; pfam00394 856793003099 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 856793003100 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 856793003101 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 856793003102 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 856793003103 Uncharacterized conserved protein [Function unknown]; Region: COG3350 856793003104 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 856793003105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 856793003106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793003107 motif II; other site 856793003108 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793003109 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 856793003110 active site 856793003111 catalytic residues [active] 856793003112 DNA binding site [nucleotide binding] 856793003113 Int/Topo IB signature motif; other site 856793003114 Uncharacterized conserved protein [Function unknown]; Region: COG1434 856793003115 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 856793003116 putative active site [active] 856793003117 Transglycosylase SLT domain; Region: SLT_2; pfam13406 856793003118 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793003119 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793003120 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 856793003121 rare lipoprotein A; Region: rlpA; TIGR00413 856793003122 Sporulation related domain; Region: SPOR; pfam05036 856793003123 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 856793003124 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 856793003125 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 856793003126 thymidylate kinase; Validated; Region: tmk; PRK00698 856793003127 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 856793003128 TMP-binding site; other site 856793003129 ATP-binding site [chemical binding]; other site 856793003130 DNA polymerase III subunit delta'; Validated; Region: PRK07471 856793003131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003132 Walker A motif; other site 856793003133 ATP binding site [chemical binding]; other site 856793003134 Walker B motif; other site 856793003135 arginine finger; other site 856793003136 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 856793003137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 856793003138 active site 856793003139 HIGH motif; other site 856793003140 KMSKS motif; other site 856793003141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 856793003142 tRNA binding surface [nucleotide binding]; other site 856793003143 anticodon binding site; other site 856793003144 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 856793003145 active site 856793003146 putative hydrolase; Provisional; Region: PRK02113 856793003147 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 856793003148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793003149 PAS domain; Region: PAS_9; pfam13426 856793003150 putative active site [active] 856793003151 heme pocket [chemical binding]; other site 856793003152 PAS domain; Region: PAS_9; pfam13426 856793003153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793003154 putative active site [active] 856793003155 heme pocket [chemical binding]; other site 856793003156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793003157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793003158 dimer interface [polypeptide binding]; other site 856793003159 putative CheW interface [polypeptide binding]; other site 856793003160 EAL domain; Region: EAL; pfam00563 856793003161 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 856793003162 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 856793003163 homodimer interface [polypeptide binding]; other site 856793003164 metal binding site [ion binding]; metal-binding site 856793003165 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 856793003166 homodimer interface [polypeptide binding]; other site 856793003167 active site 856793003168 putative chemical substrate binding site [chemical binding]; other site 856793003169 metal binding site [ion binding]; metal-binding site 856793003170 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 856793003171 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 856793003172 active site 856793003173 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 856793003174 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 856793003175 HflX GTPase family; Region: HflX; cd01878 856793003176 G1 box; other site 856793003177 GTP/Mg2+ binding site [chemical binding]; other site 856793003178 Switch I region; other site 856793003179 G2 box; other site 856793003180 G3 box; other site 856793003181 Switch II region; other site 856793003182 G4 box; other site 856793003183 G5 box; other site 856793003184 bacterial Hfq-like; Region: Hfq; cd01716 856793003185 hexamer interface [polypeptide binding]; other site 856793003186 Sm1 motif; other site 856793003187 RNA binding site [nucleotide binding]; other site 856793003188 Sm2 motif; other site 856793003189 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 856793003190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793003191 active site 856793003192 motif I; other site 856793003193 motif II; other site 856793003194 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 856793003195 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 856793003196 homodimer interface [polypeptide binding]; other site 856793003197 substrate-cofactor binding pocket; other site 856793003198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793003199 catalytic residue [active] 856793003200 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 856793003201 TrkA-N domain; Region: TrkA_N; pfam02254 856793003202 TrkA-C domain; Region: TrkA_C; pfam02080 856793003203 TrkA-N domain; Region: TrkA_N; pfam02254 856793003204 TrkA-C domain; Region: TrkA_C; pfam02080 856793003205 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 856793003206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793003207 active site 856793003208 phosphorylation site [posttranslational modification] 856793003209 intermolecular recognition site; other site 856793003210 dimerization interface [polypeptide binding]; other site 856793003211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003212 Walker A motif; other site 856793003213 ATP binding site [chemical binding]; other site 856793003214 Walker B motif; other site 856793003215 arginine finger; other site 856793003216 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 856793003217 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 856793003218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 856793003219 dimerization interface [polypeptide binding]; other site 856793003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793003221 putative active site [active] 856793003222 heme pocket [chemical binding]; other site 856793003223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793003224 dimer interface [polypeptide binding]; other site 856793003225 phosphorylation site [posttranslational modification] 856793003226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793003227 ATP binding site [chemical binding]; other site 856793003228 Mg2+ binding site [ion binding]; other site 856793003229 G-X-G motif; other site 856793003230 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 856793003231 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 856793003232 substrate binding site; other site 856793003233 dimer interface; other site 856793003234 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 856793003235 homotrimer interaction site [polypeptide binding]; other site 856793003236 zinc binding site [ion binding]; other site 856793003237 CDP-binding sites; other site 856793003238 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 856793003239 tetramer interfaces [polypeptide binding]; other site 856793003240 binuclear metal-binding site [ion binding]; other site 856793003241 Competence-damaged protein; Region: CinA; pfam02464 856793003242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 856793003243 active site 856793003244 lipoyl synthase; Provisional; Region: PRK05481 856793003245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793003246 FeS/SAM binding site; other site 856793003247 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793003248 catalytic core [active] 856793003249 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 856793003250 catalytic triad [active] 856793003251 conserved cis-peptide bond; other site 856793003252 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 856793003253 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 856793003254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 856793003255 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 856793003256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 856793003257 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 856793003258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 856793003259 dimerization interface [polypeptide binding]; other site 856793003260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793003261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793003262 dimer interface [polypeptide binding]; other site 856793003263 putative CheW interface [polypeptide binding]; other site 856793003264 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 856793003265 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 856793003266 active site 856793003267 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 856793003268 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 856793003269 active site 856793003270 Methyltransferase domain; Region: Methyltransf_32; pfam13679 856793003271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 856793003272 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 856793003273 active site 856793003274 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 856793003275 active site 856793003276 e3 binding domain; Region: E3_binding; pfam02817 856793003277 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 856793003278 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 856793003279 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 856793003280 E3 interaction surface; other site 856793003281 lipoyl attachment site [posttranslational modification]; other site 856793003282 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 856793003283 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 856793003284 E3 interaction surface; other site 856793003285 lipoyl attachment site [posttranslational modification]; other site 856793003286 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 856793003287 alpha subunit interface [polypeptide binding]; other site 856793003288 TPP binding site [chemical binding]; other site 856793003289 heterodimer interface [polypeptide binding]; other site 856793003290 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 856793003291 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 856793003292 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 856793003293 tetramer interface [polypeptide binding]; other site 856793003294 TPP-binding site [chemical binding]; other site 856793003295 heterodimer interface [polypeptide binding]; other site 856793003296 phosphorylation loop region [posttranslational modification] 856793003297 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 856793003298 Septum formation initiator; Region: DivIC; pfam04977 856793003299 Protein of unknown function, DUF606; Region: DUF606; pfam04657 856793003300 enolase; Provisional; Region: eno; PRK00077 856793003301 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 856793003302 dimer interface [polypeptide binding]; other site 856793003303 metal binding site [ion binding]; metal-binding site 856793003304 substrate binding pocket [chemical binding]; other site 856793003305 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 856793003306 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 856793003307 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 856793003308 CTP synthetase; Validated; Region: pyrG; PRK05380 856793003309 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 856793003310 Catalytic site [active] 856793003311 active site 856793003312 UTP binding site [chemical binding]; other site 856793003313 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 856793003314 active site 856793003315 putative oxyanion hole; other site 856793003316 catalytic triad [active] 856793003317 Preprotein translocase SecG subunit; Region: SecG; pfam03840 856793003318 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 856793003319 triosephosphate isomerase; Provisional; Region: PRK14565 856793003320 substrate binding site [chemical binding]; other site 856793003321 dimer interface [polypeptide binding]; other site 856793003322 catalytic triad [active] 856793003323 SurA N-terminal domain; Region: SurA_N_3; cl07813 856793003324 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 856793003325 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 856793003326 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 856793003327 putative active site [active] 856793003328 NodB motif; other site 856793003329 LexA repressor; Validated; Region: PRK00215 856793003330 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 856793003331 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 856793003332 Catalytic site [active] 856793003333 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 856793003334 Competence protein; Region: Competence; pfam03772 856793003335 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 856793003336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793003337 active site 856793003338 HIGH motif; other site 856793003339 nucleotide binding site [chemical binding]; other site 856793003340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 856793003341 active site 856793003342 KMSKS motif; other site 856793003343 Peptidase family M48; Region: Peptidase_M48; cl12018 856793003344 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 856793003345 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 856793003346 dimer interface [polypeptide binding]; other site 856793003347 active site 856793003348 citrylCoA binding site [chemical binding]; other site 856793003349 NADH binding [chemical binding]; other site 856793003350 cationic pore residues; other site 856793003351 oxalacetate/citrate binding site [chemical binding]; other site 856793003352 coenzyme A binding site [chemical binding]; other site 856793003353 catalytic triad [active] 856793003354 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 856793003355 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 856793003356 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 856793003357 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 856793003358 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 856793003359 active site 856793003360 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 856793003361 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 856793003362 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 856793003363 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 856793003364 trimer interface [polypeptide binding]; other site 856793003365 active site 856793003366 UDP-GlcNAc binding site [chemical binding]; other site 856793003367 lipid binding site [chemical binding]; lipid-binding site 856793003368 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 856793003369 periplasmic chaperone; Provisional; Region: PRK10780 856793003370 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 856793003371 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 856793003372 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 856793003373 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 856793003374 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 856793003375 Surface antigen; Region: Bac_surface_Ag; pfam01103 856793003376 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 856793003377 RIP metalloprotease RseP; Region: TIGR00054 856793003378 active site 856793003379 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 856793003380 protein binding site [polypeptide binding]; other site 856793003381 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 856793003382 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 856793003383 putative substrate binding region [chemical binding]; other site 856793003384 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 856793003385 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 856793003386 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 856793003387 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 856793003388 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 856793003389 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 856793003390 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 856793003391 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 856793003392 catalytic residue [active] 856793003393 putative FPP diphosphate binding site; other site 856793003394 putative FPP binding hydrophobic cleft; other site 856793003395 dimer interface [polypeptide binding]; other site 856793003396 putative IPP diphosphate binding site; other site 856793003397 ribosome recycling factor; Reviewed; Region: frr; PRK00083 856793003398 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 856793003399 hinge region; other site 856793003400 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 856793003401 putative nucleotide binding site [chemical binding]; other site 856793003402 uridine monophosphate binding site [chemical binding]; other site 856793003403 homohexameric interface [polypeptide binding]; other site 856793003404 elongation factor Ts; Provisional; Region: tsf; PRK09377 856793003405 UBA/TS-N domain; Region: UBA; pfam00627 856793003406 Elongation factor TS; Region: EF_TS; pfam00889 856793003407 Elongation factor TS; Region: EF_TS; pfam00889 856793003408 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 856793003409 rRNA interaction site [nucleotide binding]; other site 856793003410 S8 interaction site; other site 856793003411 putative laminin-1 binding site; other site 856793003412 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 856793003413 ligand binding site [chemical binding]; other site 856793003414 active site 856793003415 UGI interface [polypeptide binding]; other site 856793003416 catalytic site [active] 856793003417 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 856793003418 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 856793003419 putative active site [active] 856793003420 putative PHP Thumb interface [polypeptide binding]; other site 856793003421 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 856793003422 generic binding surface I; other site 856793003423 generic binding surface II; other site 856793003424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 856793003425 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 856793003426 Walker A/P-loop; other site 856793003427 ATP binding site [chemical binding]; other site 856793003428 Q-loop/lid; other site 856793003429 ABC transporter signature motif; other site 856793003430 Walker B; other site 856793003431 D-loop; other site 856793003432 H-loop/switch region; other site 856793003433 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 856793003434 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 856793003435 FtsX-like permease family; Region: FtsX; pfam02687 856793003436 prolyl-tRNA synthetase; Provisional; Region: PRK08661 856793003437 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 856793003438 dimer interface [polypeptide binding]; other site 856793003439 motif 1; other site 856793003440 active site 856793003441 motif 2; other site 856793003442 motif 3; other site 856793003443 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 856793003444 anticodon binding site; other site 856793003445 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 856793003446 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 856793003447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 856793003448 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 856793003449 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 856793003450 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 856793003451 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 856793003452 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 856793003453 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 856793003454 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 856793003455 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 856793003456 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 856793003457 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 856793003458 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 856793003459 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 856793003460 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 856793003461 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 856793003462 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 856793003463 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 856793003464 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 856793003465 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 856793003466 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 856793003467 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 856793003468 active site 856793003469 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 856793003470 4Fe-4S binding domain; Region: Fer4; cl02805 856793003471 4Fe-4S binding domain; Region: Fer4; pfam00037 856793003472 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 856793003473 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 856793003474 NADH dehydrogenase subunit G; Validated; Region: PRK09130 856793003475 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 856793003476 catalytic loop [active] 856793003477 iron binding site [ion binding]; other site 856793003478 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 856793003479 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 856793003480 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 856793003481 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 856793003482 SLBB domain; Region: SLBB; pfam10531 856793003483 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 856793003484 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 856793003485 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 856793003486 putative dimer interface [polypeptide binding]; other site 856793003487 [2Fe-2S] cluster binding site [ion binding]; other site 856793003488 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 856793003489 NADH dehydrogenase subunit D; Validated; Region: PRK06075 856793003490 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 856793003491 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 856793003492 NADH dehydrogenase subunit B; Validated; Region: PRK06411 856793003493 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 856793003494 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 856793003495 Right handed beta helix region; Region: Beta_helix; pfam13229 856793003496 Right handed beta helix region; Region: Beta_helix; pfam13229 856793003497 Right handed beta helix region; Region: Beta_helix; pfam13229 856793003498 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 856793003499 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 856793003500 hexamer interface [polypeptide binding]; other site 856793003501 ligand binding site [chemical binding]; other site 856793003502 putative active site [active] 856793003503 NAD(P) binding site [chemical binding]; other site 856793003504 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 856793003505 IHF dimer interface [polypeptide binding]; other site 856793003506 IHF - DNA interface [nucleotide binding]; other site 856793003507 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 856793003508 Found in ATP-dependent protease La (LON); Region: LON; smart00464 856793003509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003510 Walker A motif; other site 856793003511 ATP binding site [chemical binding]; other site 856793003512 Walker B motif; other site 856793003513 arginine finger; other site 856793003514 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 856793003515 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 856793003516 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 856793003517 oligomer interface [polypeptide binding]; other site 856793003518 active site residues [active] 856793003519 trigger factor; Provisional; Region: tig; PRK01490 856793003520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 856793003521 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 856793003522 Uncharacterized conserved protein [Function unknown]; Region: COG0062 856793003523 putative carbohydrate kinase; Provisional; Region: PRK10565 856793003524 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 856793003525 putative substrate binding site [chemical binding]; other site 856793003526 putative ATP binding site [chemical binding]; other site 856793003527 glutamine synthetase; Provisional; Region: glnA; PRK09469 856793003528 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 856793003529 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 856793003530 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 856793003531 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 856793003532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793003533 Mg2+ binding site [ion binding]; other site 856793003534 G-X-G motif; other site 856793003535 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 856793003536 anchoring element; other site 856793003537 dimer interface [polypeptide binding]; other site 856793003538 ATP binding site [chemical binding]; other site 856793003539 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 856793003540 active site 856793003541 putative metal-binding site [ion binding]; other site 856793003542 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 856793003543 Dicarboxylate transport; Region: DctA-YdbH; cl14674 856793003544 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 856793003545 OstA-like protein; Region: OstA; cl00844 856793003546 Organic solvent tolerance protein; Region: OstA_C; pfam04453 856793003547 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 856793003548 DEAD-like helicases superfamily; Region: DEXDc; smart00487 856793003549 ATP binding site [chemical binding]; other site 856793003550 Mg++ binding site [ion binding]; other site 856793003551 motif III; other site 856793003552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793003553 nucleotide binding region [chemical binding]; other site 856793003554 ATP-binding site [chemical binding]; other site 856793003555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793003556 S-adenosylmethionine binding site [chemical binding]; other site 856793003557 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 856793003558 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 856793003559 substrate-cofactor binding pocket; other site 856793003560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793003561 catalytic residue [active] 856793003562 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 856793003563 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 856793003564 NAD(P) binding site [chemical binding]; other site 856793003565 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 856793003566 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 856793003567 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 856793003568 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 856793003569 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 856793003570 Na binding site [ion binding]; other site 856793003571 putative glycosylation site [posttranslational modification]; other site 856793003572 putative glycosylation site [posttranslational modification]; other site 856793003573 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 856793003574 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 856793003575 tetramer interface [polypeptide binding]; other site 856793003576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793003577 catalytic residue [active] 856793003578 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 856793003579 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 856793003580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793003581 catalytic residue [active] 856793003582 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 856793003583 GIY-YIG motif/motif A; other site 856793003584 putative active site [active] 856793003585 putative metal binding site [ion binding]; other site 856793003586 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 856793003587 lipoyl attachment site [posttranslational modification]; other site 856793003588 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 856793003589 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 856793003590 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 856793003591 Predicted flavoprotein [General function prediction only]; Region: COG0431 856793003592 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 856793003593 DNA-binding site [nucleotide binding]; DNA binding site 856793003594 RNA-binding motif; other site 856793003595 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 856793003596 DEAD-like helicases superfamily; Region: DEXDc; smart00487 856793003597 ATP binding site [chemical binding]; other site 856793003598 Mg++ binding site [ion binding]; other site 856793003599 motif III; other site 856793003600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793003601 nucleotide binding region [chemical binding]; other site 856793003602 ATP-binding site [chemical binding]; other site 856793003603 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 856793003604 NlpC/P60 family; Region: NLPC_P60; cl17555 856793003605 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 856793003606 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 856793003607 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 856793003608 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 856793003609 putrescine transporter; Provisional; Region: potE; PRK10655 856793003610 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 856793003611 Clp amino terminal domain; Region: Clp_N; pfam02861 856793003612 Clp amino terminal domain; Region: Clp_N; pfam02861 856793003613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003614 Walker A motif; other site 856793003615 ATP binding site [chemical binding]; other site 856793003616 Walker B motif; other site 856793003617 arginine finger; other site 856793003618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003619 Walker A motif; other site 856793003620 ATP binding site [chemical binding]; other site 856793003621 Walker B motif; other site 856793003622 arginine finger; other site 856793003623 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 856793003624 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 856793003625 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 856793003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793003627 peptide chain release factor 1; Validated; Region: prfA; PRK00591 856793003628 This domain is found in peptide chain release factors; Region: PCRF; smart00937 856793003629 RF-1 domain; Region: RF-1; pfam00472 856793003630 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 856793003631 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 856793003632 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 856793003633 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 856793003634 HSP70 interaction site [polypeptide binding]; other site 856793003635 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 856793003636 Helix-turn-helix domain; Region: HTH_25; pfam13413 856793003637 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 856793003638 aspartate kinase; Reviewed; Region: PRK06635 856793003639 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 856793003640 putative nucleotide binding site [chemical binding]; other site 856793003641 putative catalytic residues [active] 856793003642 putative Mg ion binding site [ion binding]; other site 856793003643 putative aspartate binding site [chemical binding]; other site 856793003644 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 856793003645 putative allosteric regulatory site; other site 856793003646 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 856793003647 putative allosteric regulatory residue; other site 856793003648 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 856793003649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793003650 S-adenosylmethionine binding site [chemical binding]; other site 856793003651 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 856793003652 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 856793003653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793003654 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 856793003655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793003656 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 856793003657 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793003658 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793003659 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793003660 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 856793003661 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 856793003662 catalytic residues [active] 856793003663 diaminopimelate decarboxylase; Region: lysA; TIGR01048 856793003664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 856793003665 active site 856793003666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 856793003667 substrate binding site [chemical binding]; other site 856793003668 catalytic residues [active] 856793003669 dimer interface [polypeptide binding]; other site 856793003670 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 856793003671 Disulphide isomerase; Region: Disulph_isomer; cl05813 856793003672 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 856793003673 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 856793003674 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 856793003675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 856793003676 Walker A/P-loop; other site 856793003677 ATP binding site [chemical binding]; other site 856793003678 Q-loop/lid; other site 856793003679 ABC transporter signature motif; other site 856793003680 Walker B; other site 856793003681 D-loop; other site 856793003682 H-loop/switch region; other site 856793003683 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 856793003684 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 856793003685 putative active site [active] 856793003686 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 856793003687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 856793003688 putative acyl-acceptor binding pocket; other site 856793003689 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 856793003690 Chorismate mutase type II; Region: CM_2; smart00830 856793003691 Methyltransferase domain; Region: Methyltransf_23; pfam13489 856793003692 Methyltransferase domain; Region: Methyltransf_11; pfam08241 856793003693 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 856793003694 active site 856793003695 8-oxo-dGMP binding site [chemical binding]; other site 856793003696 nudix motif; other site 856793003697 metal binding site [ion binding]; metal-binding site 856793003698 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 856793003699 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 856793003700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 856793003701 ATP binding site [chemical binding]; other site 856793003702 putative Mg++ binding site [ion binding]; other site 856793003703 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 856793003704 SEC-C motif; Region: SEC-C; pfam02810 856793003705 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 856793003706 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 856793003707 Domain of unknown function DUF21; Region: DUF21; pfam01595 856793003708 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 856793003709 Transporter associated domain; Region: CorC_HlyC; smart01091 856793003710 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 856793003711 active site 856793003712 dimer interface [polypeptide binding]; other site 856793003713 metal binding site [ion binding]; metal-binding site 856793003714 shikimate kinase; Provisional; Region: PRK13946 856793003715 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 856793003716 ADP binding site [chemical binding]; other site 856793003717 magnesium binding site [ion binding]; other site 856793003718 putative shikimate binding site; other site 856793003719 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 856793003720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793003721 active site 856793003722 DNA binding site [nucleotide binding] 856793003723 Int/Topo IB signature motif; other site 856793003724 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 856793003725 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 856793003726 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 856793003727 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 856793003728 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 856793003729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 856793003730 HSP70 interaction site [polypeptide binding]; other site 856793003731 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 856793003732 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 856793003733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 856793003734 Walker A motif; other site 856793003735 ATP binding site [chemical binding]; other site 856793003736 Walker B motif; other site 856793003737 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 856793003738 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 856793003739 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 856793003740 metal ion-dependent adhesion site (MIDAS); other site 856793003741 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 856793003742 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 856793003743 dimer interface [polypeptide binding]; other site 856793003744 motif 1; other site 856793003745 active site 856793003746 motif 2; other site 856793003747 motif 3; other site 856793003748 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 856793003749 anticodon binding site; other site 856793003750 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 856793003751 intersubunit interface [polypeptide binding]; other site 856793003752 active site 856793003753 catalytic residue [active] 856793003754 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 856793003755 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 856793003756 NAD(P) binding site [chemical binding]; other site 856793003757 catalytic residues [active] 856793003758 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 856793003759 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 856793003760 NAD(P) binding site [chemical binding]; other site 856793003761 Zeta toxin; Region: Zeta_toxin; pfam06414 856793003762 Fe-S metabolism associated domain; Region: SufE; cl00951 856793003763 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 856793003764 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 856793003765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793003766 Walker A motif; other site 856793003767 ATP binding site [chemical binding]; other site 856793003768 Walker B motif; other site 856793003769 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 856793003770 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 856793003771 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 856793003772 DNA photolyase; Region: DNA_photolyase; pfam00875 856793003773 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 856793003774 dimer interface [polypeptide binding]; other site 856793003775 catalytic triad [active] 856793003776 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 856793003777 EamA-like transporter family; Region: EamA; pfam00892 856793003778 EamA-like transporter family; Region: EamA; cl17759 856793003779 Ferredoxin [Energy production and conversion]; Region: COG1146 856793003780 4Fe-4S binding domain; Region: Fer4; pfam00037 856793003781 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 856793003782 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 856793003783 putative protein phosphatase; Region: PHA02239 856793003784 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 856793003785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 856793003786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 856793003787 DNA binding residues [nucleotide binding] 856793003788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 856793003789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793003790 Coenzyme A binding pocket [chemical binding]; other site 856793003791 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 856793003792 Peptidase family M48; Region: Peptidase_M48; pfam01435 856793003793 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 856793003794 Staphylococcal nuclease homologues; Region: SNc; smart00318 856793003795 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 856793003796 Catalytic site; other site 856793003797 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 856793003798 Phosphoglycerate kinase; Region: PGK; pfam00162 856793003799 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 856793003800 substrate binding site [chemical binding]; other site 856793003801 hinge regions; other site 856793003802 ADP binding site [chemical binding]; other site 856793003803 catalytic site [active] 856793003804 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 856793003805 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 856793003806 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 856793003807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 856793003808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793003809 catalytic residue [active] 856793003810 AMP nucleosidase; Provisional; Region: PRK08292 856793003811 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 856793003812 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 856793003813 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 856793003814 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 856793003815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 856793003816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793003817 catalytic core [active] 856793003818 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 856793003819 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 856793003820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793003821 FeS/SAM binding site; other site 856793003822 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 856793003823 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 856793003824 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 856793003825 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793003826 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 856793003827 signal recognition particle protein; Provisional; Region: PRK10867 856793003828 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 856793003829 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 856793003830 P loop; other site 856793003831 GTP binding site [chemical binding]; other site 856793003832 Signal peptide binding domain; Region: SRP_SPB; pfam02978 856793003833 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 856793003834 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 856793003835 RimM N-terminal domain; Region: RimM; pfam01782 856793003836 PRC-barrel domain; Region: PRC; pfam05239 856793003837 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 856793003838 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 856793003839 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 856793003840 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 856793003841 substrate binding site [chemical binding]; other site 856793003842 ligand binding site [chemical binding]; other site 856793003843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 856793003844 Zn2+ binding site [ion binding]; other site 856793003845 Mg2+ binding site [ion binding]; other site 856793003846 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 856793003847 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 856793003848 substrate binding site [chemical binding]; other site 856793003849 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 856793003850 tartrate dehydrogenase; Region: TTC; TIGR02089 856793003851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 856793003852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 856793003853 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 856793003854 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 856793003855 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 856793003856 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 856793003857 Walker A motif; other site 856793003858 ATP binding site [chemical binding]; other site 856793003859 Walker B motif; other site 856793003860 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 856793003861 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 856793003862 Walker A motif; other site 856793003863 ATP binding site [chemical binding]; other site 856793003864 Walker B motif; other site 856793003865 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 856793003866 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 856793003867 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 856793003868 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 856793003869 TPR repeat; Region: TPR_11; pfam13414 856793003870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793003871 binding surface 856793003872 TPR motif; other site 856793003873 Tetratricopeptide repeat; Region: TPR_12; pfam13424 856793003874 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 856793003875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 856793003876 Walker A/P-loop; other site 856793003877 ATP binding site [chemical binding]; other site 856793003878 Q-loop/lid; other site 856793003879 ABC transporter signature motif; other site 856793003880 Walker B; other site 856793003881 D-loop; other site 856793003882 H-loop/switch region; other site 856793003883 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 856793003884 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 856793003885 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 856793003886 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 856793003887 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 856793003888 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 856793003889 Walker A motif; other site 856793003890 ATP binding site [chemical binding]; other site 856793003891 Walker B motif; other site 856793003892 Predicted esterase [General function prediction only]; Region: COG0400 856793003893 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 856793003894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 856793003895 Zn binding site [ion binding]; other site 856793003896 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 856793003897 Zn binding site [ion binding]; other site 856793003898 Transmembrane secretion effector; Region: MFS_3; pfam05977 856793003899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 856793003900 putative substrate translocation pore; other site 856793003901 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 856793003902 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 856793003903 active site 856793003904 Isochorismatase family; Region: Isochorismatase; pfam00857 856793003905 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 856793003906 catalytic triad [active] 856793003907 dimer interface [polypeptide binding]; other site 856793003908 conserved cis-peptide bond; other site 856793003909 Pirin-related protein [General function prediction only]; Region: COG1741 856793003910 Pirin; Region: Pirin; pfam02678 856793003911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 856793003912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 856793003913 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 856793003914 putative effector binding pocket; other site 856793003915 dimerization interface [polypeptide binding]; other site 856793003916 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 856793003917 Ligand binding site [chemical binding]; other site 856793003918 Electron transfer flavoprotein domain; Region: ETF; pfam01012 856793003919 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 856793003920 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 856793003921 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 856793003922 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 856793003923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 856793003924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 856793003925 putative acyl-acceptor binding pocket; other site 856793003926 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 856793003927 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 856793003928 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 856793003929 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 856793003930 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 856793003931 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 856793003932 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 856793003933 putative acyl-acceptor binding pocket; other site 856793003934 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 856793003935 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 856793003936 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 856793003937 active site 856793003938 NAD synthetase; Provisional; Region: PRK13981 856793003939 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 856793003940 multimer interface [polypeptide binding]; other site 856793003941 active site 856793003942 catalytic triad [active] 856793003943 protein interface 1 [polypeptide binding]; other site 856793003944 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 856793003945 homodimer interface [polypeptide binding]; other site 856793003946 NAD binding pocket [chemical binding]; other site 856793003947 ATP binding pocket [chemical binding]; other site 856793003948 Mg binding site [ion binding]; other site 856793003949 active-site loop [active] 856793003950 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 856793003951 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 856793003952 HIGH motif; other site 856793003953 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 856793003954 active site 856793003955 KMSKS motif; other site 856793003956 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 856793003957 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 856793003958 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 856793003959 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 856793003960 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 856793003961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 856793003962 RNA binding surface [nucleotide binding]; other site 856793003963 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 856793003964 Autotransporter beta-domain; Region: Autotransporter; pfam03797 856793003965 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 856793003966 RNB domain; Region: RNB; pfam00773 856793003967 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 856793003968 active site 856793003969 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 856793003970 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 856793003971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 856793003972 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 856793003973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 856793003974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 856793003975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 856793003976 DNA binding residues [nucleotide binding] 856793003977 DNA primase; Validated; Region: dnaG; PRK05667 856793003978 CHC2 zinc finger; Region: zf-CHC2; pfam01807 856793003979 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 856793003980 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 856793003981 active site 856793003982 metal binding site [ion binding]; metal-binding site 856793003983 interdomain interaction site; other site 856793003984 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 856793003985 Yqey-like protein; Region: YqeY; pfam09424 856793003986 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 856793003987 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 856793003988 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 856793003989 catalytic site [active] 856793003990 subunit interface [polypeptide binding]; other site 856793003991 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 856793003992 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 856793003993 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 856793003994 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 856793003995 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 856793003996 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 856793003997 ATP-grasp domain; Region: ATP-grasp_4; cl17255 856793003998 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 856793003999 IMP binding site; other site 856793004000 dimer interface [polypeptide binding]; other site 856793004001 interdomain contacts; other site 856793004002 partial ornithine binding site; other site 856793004003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793004004 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 856793004005 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 856793004006 Walker A/P-loop; other site 856793004007 ATP binding site [chemical binding]; other site 856793004008 Q-loop/lid; other site 856793004009 ABC transporter signature motif; other site 856793004010 Walker B; other site 856793004011 D-loop; other site 856793004012 H-loop/switch region; other site 856793004013 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 856793004014 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 856793004015 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 856793004016 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 856793004017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 856793004018 dimerization interface [polypeptide binding]; other site 856793004019 putative DNA binding site [nucleotide binding]; other site 856793004020 putative Zn2+ binding site [ion binding]; other site 856793004021 AsnC family; Region: AsnC_trans_reg; pfam01037 856793004022 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 856793004023 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 856793004024 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 856793004025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 856793004026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 856793004027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 856793004028 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 856793004029 putative effector binding pocket; other site 856793004030 dimerization interface [polypeptide binding]; other site 856793004031 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 856793004032 active site 856793004033 nucleophile elbow; other site 856793004034 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 856793004035 active site 856793004036 nucleophile elbow; other site 856793004037 aspartate aminotransferase; Provisional; Region: PRK05764 856793004038 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 856793004039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793004040 homodimer interface [polypeptide binding]; other site 856793004041 catalytic residue [active] 856793004042 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 856793004043 Prephenate dehydratase; Region: PDT; pfam00800 856793004044 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 856793004045 putative L-Phe binding site [chemical binding]; other site 856793004046 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 856793004047 Phosphotransferase enzyme family; Region: APH; pfam01636 856793004048 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 856793004049 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 856793004050 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 856793004051 NAD(P) binding pocket [chemical binding]; other site 856793004052 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 856793004053 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 856793004054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793004055 ATP binding site [chemical binding]; other site 856793004056 putative Mg++ binding site [ion binding]; other site 856793004057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793004058 nucleotide binding region [chemical binding]; other site 856793004059 ATP-binding site [chemical binding]; other site 856793004060 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 856793004061 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 856793004062 Predicted amidohydrolase [General function prediction only]; Region: COG0388 856793004063 active site 856793004064 catalytic triad [active] 856793004065 dimer interface [polypeptide binding]; other site 856793004066 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 856793004067 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 856793004068 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 856793004069 generic binding surface II; other site 856793004070 ssDNA binding site; other site 856793004071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793004072 ATP binding site [chemical binding]; other site 856793004073 putative Mg++ binding site [ion binding]; other site 856793004074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793004075 nucleotide binding region [chemical binding]; other site 856793004076 ATP-binding site [chemical binding]; other site 856793004077 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 856793004078 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 856793004079 serine O-acetyltransferase; Region: cysE; TIGR01172 856793004080 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 856793004081 trimer interface [polypeptide binding]; other site 856793004082 active site 856793004083 substrate binding site [chemical binding]; other site 856793004084 CoA binding site [chemical binding]; other site 856793004085 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 856793004086 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 856793004087 dimer interface [polypeptide binding]; other site 856793004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793004089 catalytic residue [active] 856793004090 Uncharacterized conserved protein [Function unknown]; Region: COG2928 856793004091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793004092 non-specific DNA binding site [nucleotide binding]; other site 856793004093 salt bridge; other site 856793004094 sequence-specific DNA binding site [nucleotide binding]; other site 856793004095 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 856793004096 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 856793004097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793004098 non-specific DNA binding site [nucleotide binding]; other site 856793004099 salt bridge; other site 856793004100 sequence-specific DNA binding site [nucleotide binding]; other site 856793004101 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 856793004102 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 856793004103 active site 856793004104 (T/H)XGH motif; other site 856793004105 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 856793004106 nudix motif; other site 856793004107 DNA gyrase subunit A; Validated; Region: PRK05560 856793004108 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 856793004109 CAP-like domain; other site 856793004110 active site 856793004111 primary dimer interface [polypeptide binding]; other site 856793004112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 856793004113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 856793004114 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 856793004115 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 856793004116 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 856793004117 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 856793004118 nucleotide binding site/active site [active] 856793004119 HIT family signature motif; other site 856793004120 catalytic residue [active] 856793004121 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 856793004122 nucleotide binding site/active site [active] 856793004123 HIT family signature motif; other site 856793004124 catalytic residue [active] 856793004125 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 856793004126 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 856793004127 Methyltransferase domain; Region: Methyltransf_23; pfam13489 856793004128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793004129 S-adenosylmethionine binding site [chemical binding]; other site 856793004130 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 856793004131 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 856793004132 dimer interface [polypeptide binding]; other site 856793004133 ssDNA binding site [nucleotide binding]; other site 856793004134 tetramer (dimer of dimers) interface [polypeptide binding]; other site 856793004135 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 856793004136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793004137 Walker A motif; other site 856793004138 ATP binding site [chemical binding]; other site 856793004139 Walker B motif; other site 856793004140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 856793004141 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 856793004142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793004143 Walker A motif; other site 856793004144 ATP binding site [chemical binding]; other site 856793004145 Walker B motif; other site 856793004146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793004147 Walker A motif; other site 856793004148 ATP binding site [chemical binding]; other site 856793004149 Walker B motif; other site 856793004150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 856793004151 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 856793004152 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 856793004153 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 856793004154 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 856793004155 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 856793004156 HSP70 interaction site [polypeptide binding]; other site 856793004157 Transcriptional regulator; Region: Rrf2; cl17282 856793004158 Rrf2 family protein; Region: rrf2_super; TIGR00738 856793004159 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 856793004160 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 856793004161 heme-binding site [chemical binding]; other site 856793004162 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 856793004163 FAD binding pocket [chemical binding]; other site 856793004164 FAD binding motif [chemical binding]; other site 856793004165 phosphate binding motif [ion binding]; other site 856793004166 beta-alpha-beta structure motif; other site 856793004167 NAD binding pocket [chemical binding]; other site 856793004168 Heme binding pocket [chemical binding]; other site 856793004169 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 856793004170 calcium mediated ligand binding site; other site 856793004171 intermolecular salt bridges; other site 856793004172 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 856793004173 Uncharacterized conserved protein [Function unknown]; Region: COG5276 856793004174 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 856793004175 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 856793004176 trimer interface [polypeptide binding]; other site 856793004177 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 856793004178 trimer interface [polypeptide binding]; other site 856793004179 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 856793004180 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 856793004181 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 856793004182 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 856793004183 active site 856793004184 putative hydrolase; Provisional; Region: PRK11460 856793004185 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 856793004186 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 856793004187 active site 856793004188 HIGH motif; other site 856793004189 nucleotide binding site [chemical binding]; other site 856793004190 active site 856793004191 KMSKS motif; other site 856793004192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793004193 non-specific DNA binding site [nucleotide binding]; other site 856793004194 salt bridge; other site 856793004195 sequence-specific DNA binding site [nucleotide binding]; other site 856793004196 nitrilase; Region: PLN02798 856793004197 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 856793004198 putative active site [active] 856793004199 catalytic triad [active] 856793004200 dimer interface [polypeptide binding]; other site 856793004201 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 856793004202 GSH binding site [chemical binding]; other site 856793004203 catalytic residues [active] 856793004204 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 856793004205 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 856793004206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793004207 active site 856793004208 Methyltransferase domain; Region: Methyltransf_23; pfam13489 856793004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793004210 S-adenosylmethionine binding site [chemical binding]; other site 856793004211 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 856793004212 Methyltransferase domain; Region: Methyltransf_11; pfam08241 856793004213 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 856793004214 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 856793004215 active site 856793004216 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 856793004217 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 856793004218 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 856793004219 NAD(P) binding site [chemical binding]; other site 856793004220 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 856793004221 Protein of unknown function (DUF465); Region: DUF465; cl01070 856793004222 aldehyde dehydrogenase family 7 member; Region: PLN02315 856793004223 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 856793004224 tetrameric interface [polypeptide binding]; other site 856793004225 NAD binding site [chemical binding]; other site 856793004226 catalytic residues [active] 856793004227 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 856793004228 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 856793004229 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 856793004230 PhoU domain; Region: PhoU; pfam01895 856793004231 PhoU domain; Region: PhoU; pfam01895 856793004232 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 856793004233 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 856793004234 cytochrome b; Provisional; Region: CYTB; MTH00145 856793004235 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 856793004236 Qi binding site; other site 856793004237 intrachain domain interface; other site 856793004238 interchain domain interface [polypeptide binding]; other site 856793004239 heme bH binding site [chemical binding]; other site 856793004240 heme bL binding site [chemical binding]; other site 856793004241 Qo binding site; other site 856793004242 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 856793004243 interchain domain interface [polypeptide binding]; other site 856793004244 intrachain domain interface; other site 856793004245 Qi binding site; other site 856793004246 Qo binding site; other site 856793004247 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 856793004248 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 856793004249 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 856793004250 [2Fe-2S] cluster binding site [ion binding]; other site 856793004251 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 856793004252 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 856793004253 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 856793004254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 856793004255 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 856793004256 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 856793004257 active site 856793004258 NTP binding site [chemical binding]; other site 856793004259 metal binding triad [ion binding]; metal-binding site 856793004260 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 856793004261 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 856793004262 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 856793004263 MoxR-like ATPases [General function prediction only]; Region: COG0714 856793004264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793004265 Walker A motif; other site 856793004266 ATP binding site [chemical binding]; other site 856793004267 Walker B motif; other site 856793004268 arginine finger; other site 856793004269 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 856793004270 Protein of unknown function DUF58; Region: DUF58; pfam01882 856793004271 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 856793004272 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 856793004273 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 856793004274 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 856793004275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 856793004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004277 active site 856793004278 phosphorylation site [posttranslational modification] 856793004279 intermolecular recognition site; other site 856793004280 dimerization interface [polypeptide binding]; other site 856793004281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 856793004282 DNA binding residues [nucleotide binding] 856793004283 dimerization interface [polypeptide binding]; other site 856793004284 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793004285 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 856793004286 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793004287 catalytic residue [active] 856793004288 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 856793004289 dihydrodipicolinate synthase; Region: dapA; TIGR00674 856793004290 dimer interface [polypeptide binding]; other site 856793004291 active site 856793004292 catalytic residue [active] 856793004293 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 856793004294 SmpB-tmRNA interface; other site 856793004295 recombinase A; Provisional; Region: recA; PRK09354 856793004296 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 856793004297 hexamer interface [polypeptide binding]; other site 856793004298 Walker A motif; other site 856793004299 ATP binding site [chemical binding]; other site 856793004300 Walker B motif; other site 856793004301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 856793004302 Peptidase M15; Region: Peptidase_M15_3; cl01194 856793004303 PAS domain; Region: PAS_9; pfam13426 856793004304 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 856793004305 PAS domain; Region: PAS; smart00091 856793004306 putative active site [active] 856793004307 heme pocket [chemical binding]; other site 856793004308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793004309 dimer interface [polypeptide binding]; other site 856793004310 phosphorylation site [posttranslational modification] 856793004311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793004312 ATP binding site [chemical binding]; other site 856793004313 Mg2+ binding site [ion binding]; other site 856793004314 G-X-G motif; other site 856793004315 Response regulator receiver domain; Region: Response_reg; pfam00072 856793004316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004317 active site 856793004318 phosphorylation site [posttranslational modification] 856793004319 intermolecular recognition site; other site 856793004320 dimerization interface [polypeptide binding]; other site 856793004321 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 856793004322 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 856793004323 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 856793004324 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 856793004325 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 856793004326 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 856793004327 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 856793004328 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 856793004329 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 856793004330 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 856793004331 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 856793004332 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 856793004333 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 856793004334 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 856793004335 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 856793004336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 856793004337 putative metal binding site [ion binding]; other site 856793004338 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 856793004339 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 856793004340 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 856793004341 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 856793004342 ligand binding site [chemical binding]; other site 856793004343 flagellar motor protein MotD; Reviewed; Region: PRK09038 856793004344 Uncharacterized conserved protein [Function unknown]; Region: COG3334 856793004345 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 856793004346 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 856793004347 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 856793004348 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 856793004349 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 856793004350 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 856793004351 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 856793004352 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 856793004353 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 856793004354 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 856793004355 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 856793004356 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 856793004357 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 856793004358 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 856793004359 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 856793004360 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 856793004361 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 856793004362 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 856793004363 Rod binding protein; Region: Rod-binding; cl01626 856793004364 FlgN protein; Region: FlgN; pfam05130 856793004365 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 856793004366 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 856793004367 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 856793004368 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 856793004369 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 856793004370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 856793004371 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 856793004372 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 856793004373 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 856793004374 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 856793004375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793004376 Coenzyme A binding pocket [chemical binding]; other site 856793004377 glycyl-tRNA synthetase; Provisional; Region: PRK04173 856793004378 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 856793004379 motif 1; other site 856793004380 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 856793004381 active site 856793004382 motif 2; other site 856793004383 motif 3; other site 856793004384 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 856793004385 anticodon binding site; other site 856793004386 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 856793004387 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 856793004388 tandem repeat interface [polypeptide binding]; other site 856793004389 oligomer interface [polypeptide binding]; other site 856793004390 active site residues [active] 856793004391 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 856793004392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793004393 S-adenosylmethionine binding site [chemical binding]; other site 856793004394 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 856793004395 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 856793004396 substrate binding pocket [chemical binding]; other site 856793004397 chain length determination region; other site 856793004398 substrate-Mg2+ binding site; other site 856793004399 catalytic residues [active] 856793004400 aspartate-rich region 1; other site 856793004401 active site lid residues [active] 856793004402 aspartate-rich region 2; other site 856793004403 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 856793004404 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 856793004405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 856793004406 ligand binding site [chemical binding]; other site 856793004407 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 856793004408 putative homodimer interface [polypeptide binding]; other site 856793004409 putative homotetramer interface [polypeptide binding]; other site 856793004410 putative allosteric switch controlling residues; other site 856793004411 putative metal binding site [ion binding]; other site 856793004412 putative homodimer-homodimer interface [polypeptide binding]; other site 856793004413 Predicted permease; Region: DUF318; cl17795 856793004414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 856793004415 ATP binding site [chemical binding]; other site 856793004416 putative Mg++ binding site [ion binding]; other site 856793004417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 856793004418 nucleotide binding region [chemical binding]; other site 856793004419 ATP-binding site [chemical binding]; other site 856793004420 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 856793004421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793004422 FeS/SAM binding site; other site 856793004423 HemN C-terminal domain; Region: HemN_C; pfam06969 856793004424 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 856793004425 active site 856793004426 dimerization interface [polypeptide binding]; other site 856793004427 ribonuclease PH; Reviewed; Region: rph; PRK00173 856793004428 Ribonuclease PH; Region: RNase_PH_bact; cd11362 856793004429 hexamer interface [polypeptide binding]; other site 856793004430 active site 856793004431 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 856793004432 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 856793004433 heat shock protein GrpE; Provisional; Region: PRK14141 856793004434 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 856793004435 dimer interface [polypeptide binding]; other site 856793004436 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 856793004437 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 856793004438 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 856793004439 nucleotide binding site [chemical binding]; other site 856793004440 NEF interaction site [polypeptide binding]; other site 856793004441 SBD interface [polypeptide binding]; other site 856793004442 chaperone protein DnaJ; Provisional; Region: PRK10767 856793004443 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 856793004444 HSP70 interaction site [polypeptide binding]; other site 856793004445 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 856793004446 substrate binding site [polypeptide binding]; other site 856793004447 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 856793004448 Zn binding sites [ion binding]; other site 856793004449 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 856793004450 dimer interface [polypeptide binding]; other site 856793004451 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 856793004452 dihydrodipicolinate reductase; Provisional; Region: PRK00048 856793004453 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 856793004454 Helix-turn-helix domain; Region: HTH_18; pfam12833 856793004455 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 856793004456 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 856793004457 DNA binding site [nucleotide binding] 856793004458 active site 856793004459 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 856793004460 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 856793004461 minor groove reading motif; other site 856793004462 helix-hairpin-helix signature motif; other site 856793004463 substrate binding pocket [chemical binding]; other site 856793004464 active site 856793004465 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 856793004466 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 856793004467 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 856793004468 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 856793004469 GIY-YIG motif/motif A; other site 856793004470 active site 856793004471 catalytic site [active] 856793004472 putative DNA binding site [nucleotide binding]; other site 856793004473 metal binding site [ion binding]; metal-binding site 856793004474 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 856793004475 Sel1 repeat; Region: Sel1; cl02723 856793004476 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793004477 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 856793004478 Flagellar FliJ protein; Region: FliJ; pfam02050 856793004479 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 856793004480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793004481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793004482 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 856793004483 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 856793004484 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 856793004485 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 856793004486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793004487 non-specific DNA binding site [nucleotide binding]; other site 856793004488 salt bridge; other site 856793004489 sequence-specific DNA binding site [nucleotide binding]; other site 856793004490 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 856793004491 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 856793004492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793004493 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 856793004494 active site 856793004495 catalytic residues [active] 856793004496 DNA binding site [nucleotide binding] 856793004497 Int/Topo IB signature motif; other site 856793004498 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 856793004499 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 856793004500 putative MPT binding site; other site 856793004501 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 856793004502 active site 856793004503 hypothetical protein; Reviewed; Region: PRK00024 856793004504 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 856793004505 MPN+ (JAMM) motif; other site 856793004506 Zinc-binding site [ion binding]; other site 856793004507 adenylosuccinate lyase; Provisional; Region: PRK07492 856793004508 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 856793004509 tetramer interface [polypeptide binding]; other site 856793004510 active site 856793004511 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 856793004512 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 856793004513 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 856793004514 active site 856793004515 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 856793004516 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 856793004517 active site 856793004518 catalytic site [active] 856793004519 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 856793004520 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 856793004521 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 856793004522 NAD binding site [chemical binding]; other site 856793004523 Phe binding site; other site 856793004524 Nicotianamine synthase protein; Region: NAS; cl17658 856793004525 2-isopropylmalate synthase; Region: PLN02321 856793004526 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 856793004527 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 856793004528 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 856793004529 dimerization interface [polypeptide binding]; other site 856793004530 active site 856793004531 aconitate hydratase; Validated; Region: PRK09277 856793004532 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 856793004533 substrate binding site [chemical binding]; other site 856793004534 ligand binding site [chemical binding]; other site 856793004535 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 856793004536 substrate binding site [chemical binding]; other site 856793004537 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 856793004538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793004539 Walker A/P-loop; other site 856793004540 ATP binding site [chemical binding]; other site 856793004541 Q-loop/lid; other site 856793004542 ABC transporter signature motif; other site 856793004543 Walker B; other site 856793004544 D-loop; other site 856793004545 H-loop/switch region; other site 856793004546 heme exporter protein CcmB; Region: ccmB; TIGR01190 856793004547 heme exporter protein CcmC; Region: ccmC; TIGR01191 856793004548 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 856793004549 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 856793004550 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 856793004551 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 856793004552 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 856793004553 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 856793004554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793004555 TPR motif; other site 856793004556 TPR repeat; Region: TPR_11; pfam13414 856793004557 binding surface 856793004558 YGGT family; Region: YGGT; cl00508 856793004559 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 856793004560 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 856793004561 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 856793004562 homodimer interface [polypeptide binding]; other site 856793004563 NADP binding site [chemical binding]; other site 856793004564 substrate binding site [chemical binding]; other site 856793004565 isocitrate dehydrogenase; Validated; Region: PRK09222 856793004566 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 856793004567 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 856793004568 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 856793004569 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 856793004570 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 856793004571 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 856793004572 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 856793004573 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 856793004574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 856793004575 Terminase-like family; Region: Terminase_6; pfam03237 856793004576 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 856793004577 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 856793004578 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 856793004579 hypothetical protein; Region: PHA00661 856793004580 hypothetical protein; Region: PHA00661 856793004581 hypothetical protein; Region: PHA00662 856793004582 hypothetical protein; Provisional; Region: PRK11281 856793004583 PilZ domain; Region: PilZ; pfam07238 856793004584 hypothetical protein; Region: PHA00670 856793004585 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 856793004586 Predicted transcriptional regulator [Transcription]; Region: COG2932 856793004587 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 856793004588 Bacterial PH domain; Region: DUF304; pfam03703 856793004589 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 856793004590 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 856793004591 substrate binding site [chemical binding]; other site 856793004592 ATP binding site [chemical binding]; other site 856793004593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793004594 active site 856793004595 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 856793004596 ATP-NAD kinase; Region: NAD_kinase; pfam01513 856793004597 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 856793004598 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 856793004599 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 856793004600 ATP binding site [chemical binding]; other site 856793004601 active site 856793004602 substrate binding site [chemical binding]; other site 856793004603 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 856793004604 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 856793004605 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 856793004606 putative GSH binding site [chemical binding]; other site 856793004607 catalytic residues [active] 856793004608 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 856793004609 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 856793004610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 856793004611 Transporter associated domain; Region: CorC_HlyC; smart01091 856793004612 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 856793004613 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 856793004614 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 856793004615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 856793004616 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 856793004617 rod shape-determining protein MreC; Provisional; Region: PRK13922 856793004618 rod shape-determining protein MreC; Region: MreC; pfam04085 856793004619 rod shape-determining protein MreB; Provisional; Region: PRK13927 856793004620 MreB and similar proteins; Region: MreB_like; cd10225 856793004621 nucleotide binding site [chemical binding]; other site 856793004622 Mg binding site [ion binding]; other site 856793004623 putative protofilament interaction site [polypeptide binding]; other site 856793004624 RodZ interaction site [polypeptide binding]; other site 856793004625 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 856793004626 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 856793004627 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 856793004628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 856793004629 ligand binding site [chemical binding]; other site 856793004630 flexible hinge region; other site 856793004631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 856793004632 FecR protein; Region: FecR; pfam04773 856793004633 FG-GAP repeat; Region: FG-GAP; cl15299 856793004634 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 856793004635 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 856793004636 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793004637 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 856793004638 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 856793004639 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 856793004640 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 856793004641 Walker A/P-loop; other site 856793004642 ATP binding site [chemical binding]; other site 856793004643 Q-loop/lid; other site 856793004644 ABC transporter signature motif; other site 856793004645 Walker B; other site 856793004646 D-loop; other site 856793004647 H-loop/switch region; other site 856793004648 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 856793004649 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 856793004650 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 856793004651 ligand binding site [chemical binding]; other site 856793004652 homodimer interface [polypeptide binding]; other site 856793004653 NAD(P) binding site [chemical binding]; other site 856793004654 trimer interface B [polypeptide binding]; other site 856793004655 trimer interface A [polypeptide binding]; other site 856793004656 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 856793004657 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 856793004658 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 856793004659 phosphatidylserine decarboxylase; Region: PLN02964 856793004660 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 856793004661 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 856793004662 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 856793004663 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 856793004664 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 856793004665 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 856793004666 nucleotide binding pocket [chemical binding]; other site 856793004667 K-X-D-G motif; other site 856793004668 catalytic site [active] 856793004669 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 856793004670 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 856793004671 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 856793004672 Dimer interface [polypeptide binding]; other site 856793004673 BRCT sequence motif; other site 856793004674 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 856793004675 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 856793004676 Walker A/P-loop; other site 856793004677 ATP binding site [chemical binding]; other site 856793004678 Q-loop/lid; other site 856793004679 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 856793004680 ABC transporter signature motif; other site 856793004681 Walker B; other site 856793004682 D-loop; other site 856793004683 H-loop/switch region; other site 856793004684 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 856793004685 Protein of unknown function (DUF2419); Region: DUF2419; pfam10343 856793004686 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 856793004687 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 856793004688 cell division protein FtsZ; Validated; Region: PRK09330 856793004689 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 856793004690 nucleotide binding site [chemical binding]; other site 856793004691 SulA interaction site; other site 856793004692 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 856793004693 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 856793004694 Cell division protein FtsA; Region: FtsA; smart00842 856793004695 Cell division protein FtsA; Region: FtsA; pfam14450 856793004696 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 856793004697 Cell division protein FtsQ; Region: FtsQ; pfam03799 856793004698 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 856793004699 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 856793004700 ATP-grasp domain; Region: ATP-grasp_4; cl17255 856793004701 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 856793004702 FAD binding domain; Region: FAD_binding_4; pfam01565 856793004703 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 856793004704 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 856793004705 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 856793004706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 856793004707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 856793004708 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 856793004709 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 856793004710 active site 856793004711 homodimer interface [polypeptide binding]; other site 856793004712 cell division protein FtsW; Region: ftsW; TIGR02614 856793004713 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 856793004714 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 856793004715 NAD binding site [chemical binding]; other site 856793004716 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 856793004717 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 856793004718 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 856793004719 Mg++ binding site [ion binding]; other site 856793004720 putative catalytic motif [active] 856793004721 putative substrate binding site [chemical binding]; other site 856793004722 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 856793004723 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 856793004724 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 856793004725 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 856793004726 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 856793004727 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 856793004728 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 856793004729 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 856793004730 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 856793004731 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 856793004732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 856793004733 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 856793004734 MraW methylase family; Region: Methyltransf_5; cl17771 856793004735 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 856793004736 MraZ protein; Region: MraZ; pfam02381 856793004737 cell division protein MraZ; Reviewed; Region: PRK00326 856793004738 MraZ protein; Region: MraZ; pfam02381 856793004739 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 856793004740 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 856793004741 amidase catalytic site [active] 856793004742 Zn binding residues [ion binding]; other site 856793004743 substrate binding site [chemical binding]; other site 856793004744 purine nucleoside phosphorylase; Provisional; Region: PRK08202 856793004745 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 856793004746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 856793004747 putative substrate translocation pore; other site 856793004748 methionine sulfoxide reductase A; Provisional; Region: PRK14054 856793004749 Uncharacterized conserved protein [Function unknown]; Region: COG1872 856793004750 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 856793004751 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 856793004752 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 856793004753 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 856793004754 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 856793004755 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 856793004756 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 856793004757 active site 1 [active] 856793004758 dimer interface [polypeptide binding]; other site 856793004759 hexamer interface [polypeptide binding]; other site 856793004760 active site 2 [active] 856793004761 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 856793004762 L-aspartate oxidase; Provisional; Region: PRK06175 856793004763 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 856793004764 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 856793004765 putative SdhC subunit interface [polypeptide binding]; other site 856793004766 putative proximal heme binding site [chemical binding]; other site 856793004767 putative Iron-sulfur protein interface [polypeptide binding]; other site 856793004768 putative proximal quinone binding site; other site 856793004769 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 856793004770 Iron-sulfur protein interface; other site 856793004771 proximal quinone binding site [chemical binding]; other site 856793004772 SdhD (CybS) interface [polypeptide binding]; other site 856793004773 proximal heme binding site [chemical binding]; other site 856793004774 methionine sulfoxide reductase B; Provisional; Region: PRK00222 856793004775 SelR domain; Region: SelR; pfam01641 856793004776 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 856793004777 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 856793004778 PAS domain S-box; Region: sensory_box; TIGR00229 856793004779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793004780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793004781 dimer interface [polypeptide binding]; other site 856793004782 phosphorylation site [posttranslational modification] 856793004783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793004784 ATP binding site [chemical binding]; other site 856793004785 Mg2+ binding site [ion binding]; other site 856793004786 G-X-G motif; other site 856793004787 Response regulator receiver domain; Region: Response_reg; pfam00072 856793004788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004789 active site 856793004790 phosphorylation site [posttranslational modification] 856793004791 intermolecular recognition site; other site 856793004792 dimerization interface [polypeptide binding]; other site 856793004793 Response regulator receiver domain; Region: Response_reg; pfam00072 856793004794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004795 active site 856793004796 phosphorylation site [posttranslational modification] 856793004797 intermolecular recognition site; other site 856793004798 dimerization interface [polypeptide binding]; other site 856793004799 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 856793004800 putative binding surface; other site 856793004801 active site 856793004802 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 856793004803 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 856793004804 Type II/IV secretion system protein; Region: T2SE; pfam00437 856793004805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 856793004806 Walker A motif; other site 856793004807 ATP binding site [chemical binding]; other site 856793004808 Walker B motif; other site 856793004809 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 856793004810 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 856793004811 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793004812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004813 active site 856793004814 phosphorylation site [posttranslational modification] 856793004815 intermolecular recognition site; other site 856793004816 dimerization interface [polypeptide binding]; other site 856793004817 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 856793004818 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 856793004819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 856793004820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 856793004821 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 856793004822 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 856793004823 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 856793004824 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 856793004825 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 856793004826 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 856793004827 DNA protecting protein DprA; Region: dprA; TIGR00732 856793004828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793004829 FeS/SAM binding site; other site 856793004830 DNA topoisomerase I; Validated; Region: PRK06599 856793004831 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 856793004832 active site 856793004833 interdomain interaction site; other site 856793004834 putative metal-binding site [ion binding]; other site 856793004835 nucleotide binding site [chemical binding]; other site 856793004836 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 856793004837 domain I; other site 856793004838 DNA binding groove [nucleotide binding] 856793004839 phosphate binding site [ion binding]; other site 856793004840 domain II; other site 856793004841 domain III; other site 856793004842 nucleotide binding site [chemical binding]; other site 856793004843 catalytic site [active] 856793004844 domain IV; other site 856793004845 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 856793004846 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 856793004847 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 856793004848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 856793004849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793004850 non-specific DNA binding site [nucleotide binding]; other site 856793004851 salt bridge; other site 856793004852 sequence-specific DNA binding site [nucleotide binding]; other site 856793004853 ribonuclease R; Region: RNase_R; TIGR02063 856793004854 RNB domain; Region: RNB; pfam00773 856793004855 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 856793004856 RNA binding site [nucleotide binding]; other site 856793004857 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 856793004858 RNB domain; Region: RNB; pfam00773 856793004859 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 856793004860 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 856793004861 response regulator PleD; Reviewed; Region: pleD; PRK09581 856793004862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004863 active site 856793004864 phosphorylation site [posttranslational modification] 856793004865 intermolecular recognition site; other site 856793004866 dimerization interface [polypeptide binding]; other site 856793004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004868 active site 856793004869 phosphorylation site [posttranslational modification] 856793004870 intermolecular recognition site; other site 856793004871 dimerization interface [polypeptide binding]; other site 856793004872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793004873 metal binding site [ion binding]; metal-binding site 856793004874 active site 856793004875 I-site; other site 856793004876 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 856793004877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004878 active site 856793004879 phosphorylation site [posttranslational modification] 856793004880 intermolecular recognition site; other site 856793004881 dimerization interface [polypeptide binding]; other site 856793004882 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 856793004883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 856793004884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 856793004885 metal binding site [ion binding]; metal-binding site 856793004886 active site 856793004887 I-site; other site 856793004888 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 856793004889 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 856793004890 putative dimer interface [polypeptide binding]; other site 856793004891 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 856793004892 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 856793004893 dimer interface [polypeptide binding]; other site 856793004894 anticodon binding site; other site 856793004895 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 856793004896 motif 1; other site 856793004897 dimer interface [polypeptide binding]; other site 856793004898 active site 856793004899 motif 2; other site 856793004900 GAD domain; Region: GAD; pfam02938 856793004901 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 856793004902 active site 856793004903 motif 3; other site 856793004904 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 856793004905 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 856793004906 catalytic site [active] 856793004907 putative active site [active] 856793004908 putative substrate binding site [chemical binding]; other site 856793004909 HRDC domain; Region: HRDC; pfam00570 856793004910 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 856793004911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793004912 motif II; other site 856793004913 fructokinase; Reviewed; Region: PRK09557 856793004914 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 856793004915 nucleotide binding site [chemical binding]; other site 856793004916 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793004917 catalytic core [active] 856793004918 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 856793004919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 856793004920 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 856793004921 Domain of unknown function DUF20; Region: UPF0118; pfam01594 856793004922 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 856793004923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793004924 dimer interface [polypeptide binding]; other site 856793004925 phosphorylation site [posttranslational modification] 856793004926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793004927 ATP binding site [chemical binding]; other site 856793004928 Mg2+ binding site [ion binding]; other site 856793004929 G-X-G motif; other site 856793004930 Response regulator receiver domain; Region: Response_reg; pfam00072 856793004931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793004932 active site 856793004933 phosphorylation site [posttranslational modification] 856793004934 intermolecular recognition site; other site 856793004935 dimerization interface [polypeptide binding]; other site 856793004936 Hpt domain; Region: Hpt; pfam01627 856793004937 putative binding surface; other site 856793004938 active site 856793004939 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 856793004940 active site 856793004941 multimer interface [polypeptide binding]; other site 856793004942 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 856793004943 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 856793004944 motif 1; other site 856793004945 active site 856793004946 motif 2; other site 856793004947 motif 3; other site 856793004948 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 856793004949 GCN5-like protein 1 (GCN5L1); Region: GCN5L1; pfam06320 856793004950 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 856793004951 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793004952 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793004953 catalytic residue [active] 856793004954 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 856793004955 Fe-S cluster binding site [ion binding]; other site 856793004956 active site 856793004957 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 856793004958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 856793004959 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 856793004960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793004961 binding surface 856793004962 TPR motif; other site 856793004963 TPR repeat; Region: TPR_11; pfam13414 856793004964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793004965 binding surface 856793004966 TPR motif; other site 856793004967 TPR repeat; Region: TPR_11; pfam13414 856793004968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793004969 binding surface 856793004970 TPR motif; other site 856793004971 TPR repeat; Region: TPR_11; pfam13414 856793004972 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 856793004973 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 856793004974 Sel1 repeat; Region: Sel1; pfam08238 856793004975 Sel1-like repeats; Region: SEL1; smart00671 856793004976 Sel1-like repeats; Region: SEL1; smart00671 856793004977 Sel1-like repeats; Region: SEL1; smart00671 856793004978 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 856793004979 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 856793004980 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 856793004981 catalytic residues [active] 856793004982 catalytic nucleophile [active] 856793004983 Presynaptic Site I dimer interface [polypeptide binding]; other site 856793004984 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 856793004985 Synaptic Flat tetramer interface [polypeptide binding]; other site 856793004986 Synaptic Site I dimer interface [polypeptide binding]; other site 856793004987 DNA binding site [nucleotide binding] 856793004988 Recombinase; Region: Recombinase; pfam07508 856793004989 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 856793004990 ParB-like nuclease domain; Region: ParBc; pfam02195 856793004991 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 856793004992 DNA methylase; Region: N6_N4_Mtase; pfam01555 856793004993 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 856793004994 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 856793004995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 856793004996 ATP binding site [chemical binding]; other site 856793004997 putative Mg++ binding site [ion binding]; other site 856793004998 helicase superfamily c-terminal domain; Region: HELICc; smart00490 856793004999 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 856793005000 E3 interaction surface; other site 856793005001 lipoyl attachment site [posttranslational modification]; other site 856793005002 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 856793005003 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 856793005004 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 856793005005 tetramer interface [polypeptide binding]; other site 856793005006 TPP-binding site [chemical binding]; other site 856793005007 heterodimer interface [polypeptide binding]; other site 856793005008 phosphorylation loop region [posttranslational modification] 856793005009 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 856793005010 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 856793005011 alpha subunit interface [polypeptide binding]; other site 856793005012 TPP binding site [chemical binding]; other site 856793005013 heterodimer interface [polypeptide binding]; other site 856793005014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 856793005015 Autoinducer synthetase; Region: Autoind_synth; cl17404 856793005016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793005017 sequence-specific DNA binding site [nucleotide binding]; other site 856793005018 salt bridge; other site 856793005019 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 856793005020 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 856793005021 Soluble P-type ATPase [General function prediction only]; Region: COG4087 856793005022 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 856793005023 S1 domain; Region: S1_2; pfam13509 856793005024 S1 domain; Region: S1_2; pfam13509 856793005025 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 856793005026 RNA binding site [nucleotide binding]; other site 856793005027 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 856793005028 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 856793005029 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 856793005030 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 856793005031 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 856793005032 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 856793005033 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 856793005034 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 856793005035 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 856793005036 AAA domain; Region: AAA_28; pfam13521 856793005037 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 856793005038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 856793005039 Beta-Casp domain; Region: Beta-Casp; smart01027 856793005040 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 856793005041 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 856793005042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 856793005043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 856793005044 catalytic residue [active] 856793005045 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793005046 active site 856793005047 CHAP domain; Region: CHAP; cl17642 856793005048 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 856793005049 oligomer interface [polypeptide binding]; other site 856793005050 von Willebrand factor type A domain; Region: VWA_2; pfam13519 856793005051 Protein of unknown function, DUF485; Region: DUF485; pfam04341 856793005052 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 856793005053 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 856793005054 Na binding site [ion binding]; other site 856793005055 Predicted flavoproteins [General function prediction only]; Region: COG2081 856793005056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 856793005057 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 856793005058 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 856793005059 Right handed beta helix region; Region: Beta_helix; pfam13229 856793005060 Right handed beta helix region; Region: Beta_helix; pfam13229 856793005061 Right handed beta helix region; Region: Beta_helix; pfam13229 856793005062 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 856793005063 Right handed beta helix region; Region: Beta_helix; pfam13229 856793005064 Right handed beta helix region; Region: Beta_helix; pfam13229 856793005065 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 856793005066 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 856793005067 Surface antigen; Region: Bac_surface_Ag; pfam01103 856793005068 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 856793005069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793005070 Walker A/P-loop; other site 856793005071 ATP binding site [chemical binding]; other site 856793005072 Q-loop/lid; other site 856793005073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793005074 ABC transporter signature motif; other site 856793005075 Walker B; other site 856793005076 D-loop; other site 856793005077 ABC transporter; Region: ABC_tran_2; pfam12848 856793005078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 856793005079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 856793005080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 856793005081 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 856793005082 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 856793005083 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793005084 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 856793005085 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 856793005086 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 856793005087 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 856793005088 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 856793005089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005090 active site 856793005091 phosphorylation site [posttranslational modification] 856793005092 intermolecular recognition site; other site 856793005093 dimerization interface [polypeptide binding]; other site 856793005094 CheB methylesterase; Region: CheB_methylest; pfam01339 856793005095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005096 Response regulator receiver domain; Region: Response_reg; pfam00072 856793005097 active site 856793005098 phosphorylation site [posttranslational modification] 856793005099 intermolecular recognition site; other site 856793005100 dimerization interface [polypeptide binding]; other site 856793005101 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 856793005102 putative CheA interaction surface; other site 856793005103 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 856793005104 putative binding surface; other site 856793005105 active site 856793005106 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 856793005107 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 856793005108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793005109 ATP binding site [chemical binding]; other site 856793005110 Mg2+ binding site [ion binding]; other site 856793005111 G-X-G motif; other site 856793005112 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 856793005113 CheW-like domain; Region: CheW; pfam01584 856793005114 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 856793005115 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 856793005116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005117 active site 856793005118 phosphorylation site [posttranslational modification] 856793005119 intermolecular recognition site; other site 856793005120 dimerization interface [polypeptide binding]; other site 856793005121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 856793005122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793005123 dimer interface [polypeptide binding]; other site 856793005124 putative CheW interface [polypeptide binding]; other site 856793005125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793005126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005127 active site 856793005128 phosphorylation site [posttranslational modification] 856793005129 intermolecular recognition site; other site 856793005130 dimerization interface [polypeptide binding]; other site 856793005131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793005132 DNA binding site [nucleotide binding] 856793005133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 856793005134 Family of unknown function (DUF490); Region: DUF490; pfam04357 856793005135 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 856793005136 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 856793005137 Surface antigen; Region: Bac_surface_Ag; pfam01103 856793005138 Transglycosylase; Region: Transgly; cl17702 856793005139 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 856793005140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 856793005141 universal stress protein UspE; Provisional; Region: PRK11175 856793005142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 856793005143 Ligand Binding Site [chemical binding]; other site 856793005144 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 856793005145 Ligand Binding Site [chemical binding]; other site 856793005146 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 856793005147 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 856793005148 metal binding site [ion binding]; metal-binding site 856793005149 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 856793005150 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 856793005151 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 856793005152 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 856793005153 ABC-ATPase subunit interface; other site 856793005154 dimer interface [polypeptide binding]; other site 856793005155 putative PBP binding regions; other site 856793005156 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 856793005157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 856793005158 ABC-ATPase subunit interface; other site 856793005159 dimer interface [polypeptide binding]; other site 856793005160 putative PBP binding regions; other site 856793005161 manganese transport regulator MntR; Provisional; Region: PRK11050 856793005162 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 856793005163 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 856793005164 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 856793005165 transmembrane helices; other site 856793005166 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 856793005167 TrkA-C domain; Region: TrkA_C; pfam02080 856793005168 TrkA-C domain; Region: TrkA_C; pfam02080 856793005169 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 856793005170 HemK family putative methylases; Region: hemK_fam; TIGR00536 856793005171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793005172 S-adenosylmethionine binding site [chemical binding]; other site 856793005173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 856793005174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793005175 non-specific DNA binding site [nucleotide binding]; other site 856793005176 salt bridge; other site 856793005177 sequence-specific DNA binding site [nucleotide binding]; other site 856793005178 Predicted transcriptional regulator [Transcription]; Region: COG2932 856793005179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793005180 non-specific DNA binding site [nucleotide binding]; other site 856793005181 salt bridge; other site 856793005182 sequence-specific DNA binding site [nucleotide binding]; other site 856793005183 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 856793005184 Catalytic site [active] 856793005185 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 856793005186 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 856793005187 active site 856793005188 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 856793005189 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 856793005190 G1 box; other site 856793005191 GTP/Mg2+ binding site [chemical binding]; other site 856793005192 G2 box; other site 856793005193 Switch I region; other site 856793005194 G3 box; other site 856793005195 Switch II region; other site 856793005196 G4 box; other site 856793005197 G5 box; other site 856793005198 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 856793005199 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 856793005200 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 856793005201 ligand-binding site [chemical binding]; other site 856793005202 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 856793005203 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 856793005204 Active Sites [active] 856793005205 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 856793005206 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 856793005207 active site 856793005208 SapC; Region: SapC; pfam07277 856793005209 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 856793005210 DNA binding residues [nucleotide binding] 856793005211 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 856793005212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 856793005213 active site 856793005214 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 856793005215 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793005216 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793005217 catalytic residue [active] 856793005218 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 856793005219 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 856793005220 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 856793005221 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 856793005222 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 856793005223 active site 856793005224 HIGH motif; other site 856793005225 dimer interface [polypeptide binding]; other site 856793005226 KMSKS motif; other site 856793005227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 856793005228 RNA binding surface [nucleotide binding]; other site 856793005229 Protein of unknown function; Region: DUF3971; pfam13116 856793005230 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 856793005231 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 856793005232 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 856793005233 catalytic triad [active] 856793005234 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 856793005235 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 856793005236 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 856793005237 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 856793005238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 856793005239 catalytic residue [active] 856793005240 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 856793005241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 856793005242 catalytic loop [active] 856793005243 iron binding site [ion binding]; other site 856793005244 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 856793005245 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 856793005246 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 856793005247 Ligand Binding Site [chemical binding]; other site 856793005248 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 856793005249 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 856793005250 potential catalytic triad [active] 856793005251 conserved cys residue [active] 856793005252 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 856793005253 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 856793005254 polymerase nucleotide-binding site; other site 856793005255 DNA-binding residues [nucleotide binding]; DNA binding site 856793005256 nucleotide binding site [chemical binding]; other site 856793005257 primase nucleotide-binding site [nucleotide binding]; other site 856793005258 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 856793005259 AAA domain; Region: AAA_25; pfam13481 856793005260 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 856793005261 ATP binding site [chemical binding]; other site 856793005262 Walker A motif; other site 856793005263 Walker B motif; other site 856793005264 integrase; Provisional; Region: PRK09692 856793005265 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 856793005266 active site 856793005267 Int/Topo IB signature motif; other site 856793005268 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 856793005269 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 856793005270 putative active site [active] 856793005271 putative NTP binding site [chemical binding]; other site 856793005272 putative nucleic acid binding site [nucleotide binding]; other site 856793005273 Protein of unknown function (DUF423); Region: DUF423; pfam04241 856793005274 Protein required for attachment to host cells; Region: Host_attach; pfam10116 856793005275 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 856793005276 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 856793005277 putative hydrolase; Provisional; Region: PRK11460 856793005278 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 856793005279 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 856793005280 active site 856793005281 Riboflavin kinase; Region: Flavokinase; smart00904 856793005282 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 856793005283 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793005284 active site 856793005285 HIGH motif; other site 856793005286 nucleotide binding site [chemical binding]; other site 856793005287 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 856793005288 active site 856793005289 KMSKS motif; other site 856793005290 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 856793005291 tRNA binding surface [nucleotide binding]; other site 856793005292 anticodon binding site; other site 856793005293 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 856793005294 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 856793005295 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 856793005296 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 856793005297 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 856793005298 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 856793005299 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 856793005300 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 856793005301 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 856793005302 active site 856793005303 dimer interface [polypeptide binding]; other site 856793005304 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 856793005305 dimer interface [polypeptide binding]; other site 856793005306 active site 856793005307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793005308 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 856793005309 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793005310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793005311 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793005312 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 856793005313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 856793005314 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 856793005315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793005316 ATP binding site [chemical binding]; other site 856793005317 Mg2+ binding site [ion binding]; other site 856793005318 G-X-G motif; other site 856793005319 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 856793005320 ATP binding site [chemical binding]; other site 856793005321 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 856793005322 ATP12 chaperone protein; Region: ATP12; cl02228 856793005323 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 856793005324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 856793005325 RNA binding surface [nucleotide binding]; other site 856793005326 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 856793005327 active site 856793005328 camphor resistance protein CrcB; Provisional; Region: PRK14195 856793005329 recombination factor protein RarA; Reviewed; Region: PRK13342 856793005330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793005331 Walker A motif; other site 856793005332 ATP binding site [chemical binding]; other site 856793005333 Walker B motif; other site 856793005334 arginine finger; other site 856793005335 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 856793005336 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 856793005337 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 856793005338 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 856793005339 protein binding site [polypeptide binding]; other site 856793005340 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 856793005341 protein binding site [polypeptide binding]; other site 856793005342 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 856793005343 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 856793005344 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 856793005345 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 856793005346 alphaNTD homodimer interface [polypeptide binding]; other site 856793005347 alphaNTD - beta interaction site [polypeptide binding]; other site 856793005348 alphaNTD - beta' interaction site [polypeptide binding]; other site 856793005349 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 856793005350 30S ribosomal protein S11; Validated; Region: PRK05309 856793005351 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 856793005352 30S ribosomal protein S13; Region: bact_S13; TIGR03631 856793005353 adenylate kinase; Reviewed; Region: adk; PRK00279 856793005354 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 856793005355 AMP-binding site [chemical binding]; other site 856793005356 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 856793005357 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 856793005358 SecY translocase; Region: SecY; pfam00344 856793005359 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 856793005360 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 856793005361 23S rRNA binding site [nucleotide binding]; other site 856793005362 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 856793005363 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 856793005364 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 856793005365 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 856793005366 5S rRNA interface [nucleotide binding]; other site 856793005367 23S rRNA interface [nucleotide binding]; other site 856793005368 L5 interface [polypeptide binding]; other site 856793005369 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 856793005370 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 856793005371 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 856793005372 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 856793005373 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 856793005374 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 856793005375 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 856793005376 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 856793005377 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 856793005378 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 856793005379 RNA binding site [nucleotide binding]; other site 856793005380 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 856793005381 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 856793005382 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 856793005383 putative translocon interaction site; other site 856793005384 23S rRNA interface [nucleotide binding]; other site 856793005385 signal recognition particle (SRP54) interaction site; other site 856793005386 L23 interface [polypeptide binding]; other site 856793005387 trigger factor interaction site; other site 856793005388 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 856793005389 23S rRNA interface [nucleotide binding]; other site 856793005390 5S rRNA interface [nucleotide binding]; other site 856793005391 putative antibiotic binding site [chemical binding]; other site 856793005392 L25 interface [polypeptide binding]; other site 856793005393 L27 interface [polypeptide binding]; other site 856793005394 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 856793005395 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 856793005396 G-X-X-G motif; other site 856793005397 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 856793005398 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 856793005399 protein-rRNA interface [nucleotide binding]; other site 856793005400 putative translocon binding site; other site 856793005401 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 856793005402 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 856793005403 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 856793005404 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 856793005405 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 856793005406 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 856793005407 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 856793005408 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 856793005409 elongation factor Tu; Reviewed; Region: PRK00049 856793005410 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 856793005411 G1 box; other site 856793005412 GEF interaction site [polypeptide binding]; other site 856793005413 GTP/Mg2+ binding site [chemical binding]; other site 856793005414 Switch I region; other site 856793005415 G2 box; other site 856793005416 G3 box; other site 856793005417 Switch II region; other site 856793005418 G4 box; other site 856793005419 G5 box; other site 856793005420 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 856793005421 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 856793005422 Antibiotic Binding Site [chemical binding]; other site 856793005423 elongation factor G; Reviewed; Region: PRK00007 856793005424 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 856793005425 G1 box; other site 856793005426 putative GEF interaction site [polypeptide binding]; other site 856793005427 GTP/Mg2+ binding site [chemical binding]; other site 856793005428 Switch I region; other site 856793005429 G2 box; other site 856793005430 G3 box; other site 856793005431 Switch II region; other site 856793005432 G4 box; other site 856793005433 G5 box; other site 856793005434 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 856793005435 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 856793005436 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 856793005437 30S ribosomal protein S7; Validated; Region: PRK05302 856793005438 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 856793005439 16S rRNA interaction site [nucleotide binding]; other site 856793005440 streptomycin interaction site [chemical binding]; other site 856793005441 23S rRNA interaction site [nucleotide binding]; other site 856793005442 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 856793005443 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 856793005444 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 856793005445 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 856793005446 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 856793005447 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 856793005448 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 856793005449 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 856793005450 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 856793005451 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 856793005452 DNA binding site [nucleotide binding] 856793005453 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 856793005454 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 856793005455 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 856793005456 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 856793005457 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 856793005458 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 856793005459 RPB12 interaction site [polypeptide binding]; other site 856793005460 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 856793005461 RPB3 interaction site [polypeptide binding]; other site 856793005462 RPB1 interaction site [polypeptide binding]; other site 856793005463 RPB11 interaction site [polypeptide binding]; other site 856793005464 RPB10 interaction site [polypeptide binding]; other site 856793005465 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 856793005466 core dimer interface [polypeptide binding]; other site 856793005467 peripheral dimer interface [polypeptide binding]; other site 856793005468 L10 interface [polypeptide binding]; other site 856793005469 L11 interface [polypeptide binding]; other site 856793005470 putative EF-Tu interaction site [polypeptide binding]; other site 856793005471 putative EF-G interaction site [polypeptide binding]; other site 856793005472 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 856793005473 23S rRNA interface [nucleotide binding]; other site 856793005474 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 856793005475 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 856793005476 mRNA/rRNA interface [nucleotide binding]; other site 856793005477 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 856793005478 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 856793005479 L7/L12 interface [polypeptide binding]; other site 856793005480 23S rRNA interface [nucleotide binding]; other site 856793005481 L25 interface [polypeptide binding]; other site 856793005482 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 856793005483 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 856793005484 putative homodimer interface [polypeptide binding]; other site 856793005485 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 856793005486 heterodimer interface [polypeptide binding]; other site 856793005487 homodimer interface [polypeptide binding]; other site 856793005488 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 856793005489 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 856793005490 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 856793005491 FMN binding site [chemical binding]; other site 856793005492 active site 856793005493 catalytic residues [active] 856793005494 substrate binding site [chemical binding]; other site 856793005495 SpoVR family protein; Provisional; Region: PRK11767 856793005496 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 856793005497 hypothetical protein; Provisional; Region: PRK05325 856793005498 PrkA family serine protein kinase; Provisional; Region: PRK15455 856793005499 AAA ATPase domain; Region: AAA_16; pfam13191 856793005500 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 856793005501 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 856793005502 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 856793005503 Antibiotic Binding Site [chemical binding]; other site 856793005504 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 856793005505 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 856793005506 G1 box; other site 856793005507 GEF interaction site [polypeptide binding]; other site 856793005508 GTP/Mg2+ binding site [chemical binding]; other site 856793005509 Switch I region; other site 856793005510 G2 box; other site 856793005511 G3 box; other site 856793005512 Switch II region; other site 856793005513 G4 box; other site 856793005514 G5 box; other site 856793005515 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 856793005516 HAMP domain; Region: HAMP; pfam00672 856793005517 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793005518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793005519 dimer interface [polypeptide binding]; other site 856793005520 putative CheW interface [polypeptide binding]; other site 856793005521 SEC-C motif; Region: SEC-C; pfam02810 856793005522 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 856793005523 Domain of unknown function (DUF927); Region: DUF927; pfam06048 856793005524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 856793005525 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 856793005526 active site 856793005527 metal binding site [ion binding]; metal-binding site 856793005528 interdomain interaction site; other site 856793005529 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 856793005530 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 856793005531 active site 856793005532 Int/Topo IB signature motif; other site 856793005533 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 856793005534 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 856793005535 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 856793005536 NodB motif; other site 856793005537 active site 856793005538 metal binding site [ion binding]; metal-binding site 856793005539 Glucokinase; Region: Glucokinase; cl17310 856793005540 glucokinase, proteobacterial type; Region: glk; TIGR00749 856793005541 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 856793005542 Cation efflux family; Region: Cation_efflux; cl00316 856793005543 multidrug efflux protein; Reviewed; Region: PRK09579 856793005544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 856793005545 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 856793005546 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793005547 Response regulator receiver domain; Region: Response_reg; pfam00072 856793005548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005549 active site 856793005550 phosphorylation site [posttranslational modification] 856793005551 intermolecular recognition site; other site 856793005552 dimerization interface [polypeptide binding]; other site 856793005553 Response regulator receiver domain; Region: Response_reg; pfam00072 856793005554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005555 active site 856793005556 phosphorylation site [posttranslational modification] 856793005557 intermolecular recognition site; other site 856793005558 dimerization interface [polypeptide binding]; other site 856793005559 Response regulator receiver domain; Region: Response_reg; pfam00072 856793005560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005561 active site 856793005562 phosphorylation site [posttranslational modification] 856793005563 intermolecular recognition site; other site 856793005564 dimerization interface [polypeptide binding]; other site 856793005565 CHASE3 domain; Region: CHASE3; pfam05227 856793005566 PAS fold; Region: PAS_4; pfam08448 856793005567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793005568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 856793005569 dimer interface [polypeptide binding]; other site 856793005570 phosphorylation site [posttranslational modification] 856793005571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793005572 ATP binding site [chemical binding]; other site 856793005573 Mg2+ binding site [ion binding]; other site 856793005574 G-X-G motif; other site 856793005575 Response regulator receiver domain; Region: Response_reg; pfam00072 856793005576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005577 active site 856793005578 phosphorylation site [posttranslational modification] 856793005579 intermolecular recognition site; other site 856793005580 dimerization interface [polypeptide binding]; other site 856793005581 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 856793005582 active site residue [active] 856793005583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 856793005584 dimerization interface [polypeptide binding]; other site 856793005585 putative DNA binding site [nucleotide binding]; other site 856793005586 putative Zn2+ binding site [ion binding]; other site 856793005587 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 856793005588 Predicted periplasmic protein [General function prediction only]; Region: COG3895 856793005589 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 856793005590 META domain; Region: META; pfam03724 856793005591 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 856793005592 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 856793005593 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 856793005594 putative NAD(P) binding site [chemical binding]; other site 856793005595 putative substrate binding site [chemical binding]; other site 856793005596 catalytic Zn binding site [ion binding]; other site 856793005597 structural Zn binding site [ion binding]; other site 856793005598 dimer interface [polypeptide binding]; other site 856793005599 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 856793005600 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 856793005601 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 856793005602 PhnA protein; Region: PhnA; pfam03831 856793005603 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 856793005604 Domain of unknown function DUF21; Region: DUF21; pfam01595 856793005605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 856793005606 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 856793005607 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 856793005608 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 856793005609 heme binding site [chemical binding]; other site 856793005610 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 856793005611 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 856793005612 metal binding site 2 [ion binding]; metal-binding site 856793005613 putative DNA binding helix; other site 856793005614 metal binding site 1 [ion binding]; metal-binding site 856793005615 dimer interface [polypeptide binding]; other site 856793005616 structural Zn2+ binding site [ion binding]; other site 856793005617 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 856793005618 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 856793005619 short chain dehydrogenase; Provisional; Region: PRK07024 856793005620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793005621 NAD(P) binding site [chemical binding]; other site 856793005622 active site 856793005623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 856793005624 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 856793005625 substrate binding pocket [chemical binding]; other site 856793005626 S-formylglutathione hydrolase; Region: PLN02442 856793005627 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 856793005628 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 856793005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793005630 S-adenosylmethionine binding site [chemical binding]; other site 856793005631 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 856793005632 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 856793005633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 856793005634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 856793005635 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 856793005636 dimer interface [polypeptide binding]; other site 856793005637 phosphorylation site [posttranslational modification] 856793005638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 856793005639 ATP binding site [chemical binding]; other site 856793005640 Mg2+ binding site [ion binding]; other site 856793005641 G-X-G motif; other site 856793005642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 856793005643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793005644 active site 856793005645 phosphorylation site [posttranslational modification] 856793005646 intermolecular recognition site; other site 856793005647 dimerization interface [polypeptide binding]; other site 856793005648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 856793005649 DNA binding site [nucleotide binding] 856793005650 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 856793005651 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 856793005652 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 856793005653 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 856793005654 active site 856793005655 catalytic residues [active] 856793005656 DNA binding site [nucleotide binding] 856793005657 Int/Topo IB signature motif; other site 856793005658 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 856793005659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 856793005660 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 856793005661 Ca2+ binding site [ion binding]; other site 856793005662 EF-hand domain pair; Region: EF_hand_5; pfam13499 856793005663 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 856793005664 Ca2+ binding site [ion binding]; other site 856793005665 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 856793005666 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 856793005667 HlyD family secretion protein; Region: HlyD_3; pfam13437 856793005668 Outer membrane efflux protein; Region: OEP; pfam02321 856793005669 Outer membrane efflux protein; Region: OEP; pfam02321 856793005670 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 856793005671 MobA/MobL family; Region: MobA_MobL; pfam03389 856793005672 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 856793005673 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 856793005674 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 856793005675 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 856793005676 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 856793005677 C-terminal domain interface [polypeptide binding]; other site 856793005678 GSH binding site (G-site) [chemical binding]; other site 856793005679 dimer interface [polypeptide binding]; other site 856793005680 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 856793005681 N-terminal domain interface [polypeptide binding]; other site 856793005682 dimer interface [polypeptide binding]; other site 856793005683 substrate binding pocket (H-site) [chemical binding]; other site 856793005684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 856793005685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 856793005686 TraB family; Region: TraB; pfam01963 856793005687 DNA polymerase I; Provisional; Region: PRK05755 856793005688 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 856793005689 active site 856793005690 metal binding site 1 [ion binding]; metal-binding site 856793005691 putative 5' ssDNA interaction site; other site 856793005692 metal binding site 3; metal-binding site 856793005693 metal binding site 2 [ion binding]; metal-binding site 856793005694 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 856793005695 putative DNA binding site [nucleotide binding]; other site 856793005696 putative metal binding site [ion binding]; other site 856793005697 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 856793005698 active site 856793005699 catalytic site [active] 856793005700 substrate binding site [chemical binding]; other site 856793005701 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 856793005702 active site 856793005703 DNA binding site [nucleotide binding] 856793005704 catalytic site [active] 856793005705 Ion transport protein; Region: Ion_trans; pfam00520 856793005706 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 856793005707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 856793005708 active site 856793005709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 856793005710 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 856793005711 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 856793005712 23S rRNA binding site [nucleotide binding]; other site 856793005713 L21 binding site [polypeptide binding]; other site 856793005714 L13 binding site [polypeptide binding]; other site 856793005715 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 856793005716 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 856793005717 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 856793005718 dimer interface [polypeptide binding]; other site 856793005719 motif 1; other site 856793005720 active site 856793005721 motif 2; other site 856793005722 motif 3; other site 856793005723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 856793005724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793005725 Coenzyme A binding pocket [chemical binding]; other site 856793005726 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 856793005727 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 856793005728 putative tRNA-binding site [nucleotide binding]; other site 856793005729 B3/4 domain; Region: B3_4; pfam03483 856793005730 tRNA synthetase B5 domain; Region: B5; smart00874 856793005731 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 856793005732 dimer interface [polypeptide binding]; other site 856793005733 motif 1; other site 856793005734 motif 3; other site 856793005735 motif 2; other site 856793005736 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 856793005737 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 856793005738 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 856793005739 acyl-activating enzyme (AAE) consensus motif; other site 856793005740 putative AMP binding site [chemical binding]; other site 856793005741 putative active site [active] 856793005742 putative CoA binding site [chemical binding]; other site 856793005743 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 856793005744 DNA-binding site [nucleotide binding]; DNA binding site 856793005745 RNA-binding motif; other site 856793005746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 856793005747 DNA-binding site [nucleotide binding]; DNA binding site 856793005748 RNA-binding motif; other site 856793005749 GcrA cell cycle regulator; Region: GcrA; cl11564 856793005750 GTPase Era; Reviewed; Region: era; PRK00089 856793005751 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 856793005752 G1 box; other site 856793005753 GTP/Mg2+ binding site [chemical binding]; other site 856793005754 Switch I region; other site 856793005755 G2 box; other site 856793005756 Switch II region; other site 856793005757 G3 box; other site 856793005758 G4 box; other site 856793005759 G5 box; other site 856793005760 KH domain; Region: KH_2; pfam07650 856793005761 ribonuclease III; Reviewed; Region: rnc; PRK00102 856793005762 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 856793005763 dimerization interface [polypeptide binding]; other site 856793005764 active site 856793005765 metal binding site [ion binding]; metal-binding site 856793005766 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 856793005767 dsRNA binding site [nucleotide binding]; other site 856793005768 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 856793005769 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 856793005770 Catalytic site [active] 856793005771 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 856793005772 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 856793005773 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 856793005774 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 856793005775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 856793005776 Zn2+ binding site [ion binding]; other site 856793005777 Mg2+ binding site [ion binding]; other site 856793005778 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 856793005779 synthetase active site [active] 856793005780 NTP binding site [chemical binding]; other site 856793005781 metal binding site [ion binding]; metal-binding site 856793005782 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 856793005783 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 856793005784 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 856793005785 Uncharacterized conserved protein [Function unknown]; Region: COG1432 856793005786 LabA_like proteins; Region: LabA; cd10911 856793005787 putative metal binding site [ion binding]; other site 856793005788 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 856793005789 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 856793005790 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 856793005791 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 856793005792 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 856793005793 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 856793005794 carboxyltransferase (CT) interaction site; other site 856793005795 biotinylation site [posttranslational modification]; other site 856793005796 Dehydroquinase class II; Region: DHquinase_II; pfam01220 856793005797 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 856793005798 trimer interface [polypeptide binding]; other site 856793005799 active site 856793005800 dimer interface [polypeptide binding]; other site 856793005801 Protein of unknown function (DUF461); Region: DUF461; pfam04314 856793005802 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 856793005803 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 856793005804 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 856793005805 catalytic residues [active] 856793005806 Peptidase family M48; Region: Peptidase_M48; cl12018 856793005807 TPR repeat; Region: TPR_11; pfam13414 856793005808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 856793005809 TPR motif; other site 856793005810 binding surface 856793005811 TPR repeat; Region: TPR_11; pfam13414 856793005812 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 856793005813 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 856793005814 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 856793005815 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 856793005816 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 856793005817 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 856793005818 active site 856793005819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 856793005820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 856793005821 Coenzyme A binding pocket [chemical binding]; other site 856793005822 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 856793005823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 856793005824 S-adenosylmethionine binding site [chemical binding]; other site 856793005825 GMP synthase; Reviewed; Region: guaA; PRK00074 856793005826 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 856793005827 AMP/PPi binding site [chemical binding]; other site 856793005828 candidate oxyanion hole; other site 856793005829 catalytic triad [active] 856793005830 potential glutamine specificity residues [chemical binding]; other site 856793005831 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 856793005832 ATP Binding subdomain [chemical binding]; other site 856793005833 Ligand Binding sites [chemical binding]; other site 856793005834 Dimerization subdomain; other site 856793005835 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 856793005836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 856793005837 FeS/SAM binding site; other site 856793005838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 856793005839 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 856793005840 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 856793005841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 856793005842 catalytic residue [active] 856793005843 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 856793005844 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 856793005845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 856793005846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 856793005847 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 856793005848 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 856793005849 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 856793005850 Transglycosylase; Region: Transgly; pfam00912 856793005851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 856793005852 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 856793005853 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 856793005854 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 856793005855 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 856793005856 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 856793005857 Walker A/P-loop; other site 856793005858 ATP binding site [chemical binding]; other site 856793005859 Q-loop/lid; other site 856793005860 ABC transporter signature motif; other site 856793005861 Walker B; other site 856793005862 D-loop; other site 856793005863 H-loop/switch region; other site 856793005864 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 856793005865 Permease; Region: Permease; pfam02405 856793005866 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 856793005867 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 856793005868 active site 856793005869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 856793005870 dimer interface [polypeptide binding]; other site 856793005871 substrate binding site [chemical binding]; other site 856793005872 catalytic residues [active] 856793005873 replicative DNA helicase; Provisional; Region: PRK09165 856793005874 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 856793005875 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 856793005876 Walker A motif; other site 856793005877 ATP binding site [chemical binding]; other site 856793005878 Walker B motif; other site 856793005879 DNA binding loops [nucleotide binding] 856793005880 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 856793005881 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 856793005882 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 856793005883 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 856793005884 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 856793005885 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 856793005886 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 856793005887 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 856793005888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 856793005889 PAS fold; Region: PAS_3; pfam08447 856793005890 putative active site [active] 856793005891 heme pocket [chemical binding]; other site 856793005892 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 856793005893 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 856793005894 dimer interface [polypeptide binding]; other site 856793005895 putative CheW interface [polypeptide binding]; other site 856793005896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 856793005897 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 856793005898 NAD(P) binding site [chemical binding]; other site 856793005899 homotetramer interface [polypeptide binding]; other site 856793005900 homodimer interface [polypeptide binding]; other site 856793005901 active site 856793005902 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 856793005903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 856793005904 motif II; other site 856793005905 acyl carrier protein; Provisional; Region: acpP; PRK00982 856793005906 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 856793005907 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 856793005908 dimer interface [polypeptide binding]; other site 856793005909 active site 856793005910 YceG-like family; Region: YceG; pfam02618 856793005911 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 856793005912 dimerization interface [polypeptide binding]; other site 856793005913 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 856793005914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 856793005915 sequence-specific DNA binding site [nucleotide binding]; other site 856793005916 salt bridge; other site 856793005917 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 856793005918 putative deacylase active site [active] 856793005919 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 856793005920 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 856793005921 catalytic residues [active] 856793005922 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 856793005923 Uncharacterized conserved protein [Function unknown]; Region: COG2835 856793005924 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 856793005925 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 856793005926 active site 856793005927 catalytic residues [active] 856793005928 metal binding site [ion binding]; metal-binding site 856793005929 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 856793005930 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 856793005931 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 856793005932 mce related protein; Region: MCE; pfam02470 856793005933 NADH dehydrogenase; Validated; Region: PRK08183 856793005934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 856793005935 active site 856793005936 phosphorylation site [posttranslational modification] 856793005937 intermolecular recognition site; other site 856793005938 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 856793005939 nucleoside/Zn binding site; other site 856793005940 dimer interface [polypeptide binding]; other site 856793005941 catalytic motif [active] 856793005942 Clp protease; Region: CLP_protease; pfam00574 856793005943 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 856793005944 oligomer interface [polypeptide binding]; other site 856793005945 active site residues [active] 856793005946 GDYXXLXY protein; Region: GDYXXLXY; cl02066 856793005947 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 856793005948 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 856793005949 Clp amino terminal domain; Region: Clp_N; pfam02861 856793005950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793005951 Walker A motif; other site 856793005952 ATP binding site [chemical binding]; other site 856793005953 Walker B motif; other site 856793005954 arginine finger; other site 856793005955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793005956 Walker A motif; other site 856793005957 ATP binding site [chemical binding]; other site 856793005958 Walker B motif; other site 856793005959 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 856793005960 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 856793005961 Clp amino terminal domain; Region: Clp_N; pfam02861 856793005962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793005963 Walker A motif; other site 856793005964 ATP binding site [chemical binding]; other site 856793005965 Walker B motif; other site 856793005966 arginine finger; other site 856793005967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793005968 Walker A motif; other site 856793005969 ATP binding site [chemical binding]; other site 856793005970 Walker B motif; other site 856793005971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 856793005972 Uncharacterized conserved protein [Function unknown]; Region: COG2127 856793005973 Phasin protein; Region: Phasin_2; pfam09361 856793005974 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 856793005975 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 856793005976 short chain dehydrogenase; Provisional; Region: PRK08278 856793005977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 856793005978 NAD(P) binding site [chemical binding]; other site 856793005979 active site 856793005980 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 856793005981 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 856793005982 putative ribose interaction site [chemical binding]; other site 856793005983 putative ADP binding site [chemical binding]; other site 856793005984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 856793005985 active site 856793005986 nucleotide binding site [chemical binding]; other site 856793005987 HIGH motif; other site 856793005988 KMSKS motif; other site 856793005989 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 856793005990 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 856793005991 Class I ribonucleotide reductase; Region: RNR_I; cd01679 856793005992 active site 856793005993 dimer interface [polypeptide binding]; other site 856793005994 catalytic residues [active] 856793005995 effector binding site; other site 856793005996 R2 peptide binding site; other site 856793005997 Predicted kinase [General function prediction only]; Region: COG0645 856793005998 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 856793005999 active site 856793006000 pyruvate kinase; Provisional; Region: PRK06247 856793006001 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 856793006002 domain interfaces; other site 856793006003 active site 856793006004 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 856793006005 trimer interface [polypeptide binding]; other site 856793006006 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 856793006007 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 856793006008 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 856793006009 catalytic core [active] 856793006010 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 856793006011 dimer interface [polypeptide binding]; other site 856793006012 putative radical transfer pathway; other site 856793006013 diiron center [ion binding]; other site 856793006014 tyrosyl radical; other site 856793006015 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 856793006016 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 856793006017 DEAD-like helicases superfamily; Region: DEXDc; smart00487 856793006018 PhoH-like protein; Region: PhoH; pfam02562 856793006019 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 856793006020 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 856793006021 Cu(I) binding site [ion binding]; other site 856793006022 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 856793006023 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 856793006024 active site 856793006025 SCP-2 sterol transfer family; Region: SCP2; pfam02036 856793006026 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 856793006027 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 856793006028 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 856793006029 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 856793006030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 856793006031 active site 856793006032 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 856793006033 cytidine deaminase, homodimeric; Region: cyt_deam_dimer; TIGR01355 856793006034 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 856793006035 active site 856793006036 catalytic motif [active] 856793006037 Zn binding site [ion binding]; other site 856793006038 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 856793006039 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 856793006040 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 856793006041 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 856793006042 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 856793006043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 856793006044 substrate binding site [chemical binding]; other site 856793006045 oxyanion hole (OAH) forming residues; other site 856793006046 trimer interface [polypeptide binding]; other site 856793006047 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 856793006048 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 856793006049 dimer interface [polypeptide binding]; other site 856793006050 active site 856793006051 TIGR02300 family protein; Region: FYDLN_acid 856793006052 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 856793006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 856793006054 S-adenosylmethionine binding site [chemical binding]; other site 856793006055 conserved hypothetical protein; Region: MG423; TIGR00649 856793006056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 856793006057 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 856793006058 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 856793006059 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 856793006060 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 856793006061 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 856793006062 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 856793006063 glutaminase active site [active] 856793006064 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 856793006065 dimer interface [polypeptide binding]; other site 856793006066 active site 856793006067 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 856793006068 dimer interface [polypeptide binding]; other site 856793006069 active site 856793006070 60S acidic ribosomal protein P0; Provisional; Region: PTZ00135 856793006071 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 856793006072 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 856793006073 Substrate binding site; other site 856793006074 Mg++ binding site; other site 856793006075 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 856793006076 active site 856793006077 substrate binding site [chemical binding]; other site 856793006078 CoA binding site [chemical binding]; other site 856793006079 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 856793006080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 856793006081 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 856793006082 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 856793006083 trimer interface [polypeptide binding]; other site 856793006084 active site 856793006085 substrate binding site [chemical binding]; other site 856793006086 CoA binding site [chemical binding]; other site 856793006087 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 856793006088 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 856793006089 metal binding site [ion binding]; metal-binding site 856793006090 dimer interface [polypeptide binding]; other site 856793006091 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 856793006092 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 856793006093 dimerization interface 3.5A [polypeptide binding]; other site 856793006094 active site 856793006095 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 856793006096 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 856793006097 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 856793006098 putative active site [active] 856793006099 substrate binding site [chemical binding]; other site 856793006100 putative cosubstrate binding site; other site 856793006101 catalytic site [active] 856793006102 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 856793006103 substrate binding site [chemical binding]; other site 856793006104 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 856793006105 active site 856793006106 catalytic residues [active] 856793006107 metal binding site [ion binding]; metal-binding site 856793006108 RmuC family; Region: RmuC; pfam02646 856793006109 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 856793006110 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 856793006111 G1 box; other site 856793006112 GTP/Mg2+ binding site [chemical binding]; other site 856793006113 Switch I region; other site 856793006114 G2 box; other site 856793006115 G3 box; other site 856793006116 Switch II region; other site 856793006117 G4 box; other site 856793006118 G5 box; other site 856793006119 membrane protein insertase; Provisional; Region: PRK01318 856793006120 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 856793006121 Haemolytic domain; Region: Haemolytic; pfam01809 856793006122 Ribonuclease P; Region: Ribonuclease_P; pfam00825 856793006123 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 856793006124 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 856793006125 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 856793006126 Nitrogen regulatory protein P-II; Region: P-II; smart00938 856793006127 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 856793006128 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 856793006129 AAA-like domain; Region: AAA_10; pfam12846 856793006130 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 856793006131 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 856793006132 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 856793006133 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 856793006134 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 856793006135 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 856793006136 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 856793006137 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 856793006138 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 856793006139 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 856793006140 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 856793006141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 856793006142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 856793006143 Walker A motif; other site 856793006144 Walker A/P-loop; other site 856793006145 ATP binding site [chemical binding]; other site 856793006146 ATP binding site [chemical binding]; other site 856793006147 Walker B motif; other site 856793006148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 856793006149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 856793006150 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 856793006151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 856793006152 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 856793006153 Peptidase family M48; Region: Peptidase_M48; cl12018 856793006154 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 856793006155 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 856793006156 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 856793006157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 856793006158 active site 856793006159 phosphorylation site [posttranslational modification] 856793006160 intermolecular recognition site; other site 856793006161 dimerization interface [polypeptide binding]; other site 856793006162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793006163 Walker A motif; other site 856793006164 ATP binding site [chemical binding]; other site 856793006165 Walker B motif; other site 856793006166 arginine finger; other site 856793006167 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 856793006168 integrase; Provisional; Region: PRK09692 856793006169 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 856793006170 active site 856793006171 Int/Topo IB signature motif; other site 856793006172 Helix-turn-helix domain; Region: HTH_17; pfam12728 856793006173 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 856793006174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 856793006175 non-specific DNA binding site [nucleotide binding]; other site 856793006176 salt bridge; other site 856793006177 sequence-specific DNA binding site [nucleotide binding]; other site 856793006178 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 856793006179 ligand binding surface [chemical binding]; other site 856793006180 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 856793006181 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 856793006182 Entericidin EcnA/B family; Region: Entericidin; cl02322 856793006183 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 856793006184 O-Antigen ligase; Region: Wzy_C; pfam04932 856793006185 SseB protein; Region: SseB; cl06279 856793006186 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 856793006187 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 856793006188 MltA specific insert domain; Region: MltA; smart00925 856793006189 3D domain; Region: 3D; pfam06725 856793006190 Tim44-like domain; Region: Tim44; pfam04280 856793006191 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 856793006192 preprotein translocase subunit SecB; Validated; Region: PRK05751 856793006193 SecA binding site; other site 856793006194 Preprotein binding site; other site 856793006195 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 856793006196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793006197 Walker A motif; other site 856793006198 ATP binding site [chemical binding]; other site 856793006199 Walker B motif; other site 856793006200 arginine finger; other site 856793006201 Peptidase family M41; Region: Peptidase_M41; pfam01434 856793006202 FtsH Extracellular; Region: FtsH_ext; pfam06480 856793006203 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 856793006204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 856793006205 Walker A motif; other site 856793006206 ATP binding site [chemical binding]; other site 856793006207 Walker B motif; other site 856793006208 arginine finger; other site 856793006209 Peptidase family M41; Region: Peptidase_M41; pfam01434 856793006210 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 856793006211 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 856793006212 active site 856793006213 catalytic site [active] 856793006214 substrate binding site [chemical binding]; other site 856793006215 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 856793006216 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 856793006217 catalytic triad [active] 856793006218 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 856793006219 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 856793006220 CoA-binding site [chemical binding]; other site 856793006221 ATP-binding [chemical binding]; other site 856793006222 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 856793006223 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 856793006224 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 856793006225 shikimate binding site; other site 856793006226 NAD(P) binding site [chemical binding]; other site 856793006227 PEP synthetase regulatory protein; Provisional; Region: PRK05339