-- dump date 20140619_145741 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1173027000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1173027000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1173027000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027000004 Walker A motif; other site 1173027000005 ATP binding site [chemical binding]; other site 1173027000006 Walker B motif; other site 1173027000007 arginine finger; other site 1173027000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1173027000009 DnaA box-binding interface [nucleotide binding]; other site 1173027000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173027000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173027000012 putative DNA binding surface [nucleotide binding]; other site 1173027000013 dimer interface [polypeptide binding]; other site 1173027000014 beta-clamp/clamp loader binding surface; other site 1173027000015 beta-clamp/translesion DNA polymerase binding surface; other site 1173027000016 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027000017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000018 active site 1173027000019 phosphorylation site [posttranslational modification] 1173027000020 intermolecular recognition site; other site 1173027000021 dimerization interface [polypeptide binding]; other site 1173027000022 Predicted transcriptional regulator [Transcription]; Region: COG3682 1173027000023 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173027000024 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173027000025 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173027000026 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027000027 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1173027000028 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1173027000029 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1173027000030 putative active site; other site 1173027000031 catalytic residue [active] 1173027000032 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027000033 HSP70 interaction site [polypeptide binding]; other site 1173027000034 aspartate aminotransferase; Provisional; Region: PRK05764 1173027000035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027000036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027000037 homodimer interface [polypeptide binding]; other site 1173027000038 catalytic residue [active] 1173027000039 Amino acid permease; Region: AA_permease; pfam00324 1173027000040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027000041 Ligand Binding Site [chemical binding]; other site 1173027000042 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027000043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000046 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027000047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027000049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027000050 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027000051 active site 1173027000052 Int/Topo IB signature motif; other site 1173027000053 DNA binding site [nucleotide binding] 1173027000054 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173027000055 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173027000056 Di-iron ligands [ion binding]; other site 1173027000057 Yqey-like protein; Region: YqeY; pfam09424 1173027000058 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1173027000059 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173027000060 Acylphosphatase; Region: Acylphosphatase; cl00551 1173027000061 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1173027000062 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173027000063 EamA-like transporter family; Region: EamA; pfam00892 1173027000064 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1173027000065 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1173027000066 hinge; other site 1173027000067 active site 1173027000068 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1173027000069 MPN+ (JAMM) motif; other site 1173027000070 Zinc-binding site [ion binding]; other site 1173027000071 hypothetical protein; Validated; Region: PRK07411 1173027000072 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1173027000073 ATP binding site [chemical binding]; other site 1173027000074 substrate interface [chemical binding]; other site 1173027000075 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027000076 active site residue [active] 1173027000077 MFS/sugar transport protein; Region: MFS_2; pfam13347 1173027000078 hypothetical protein; Provisional; Region: PRK07394 1173027000079 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173027000080 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173027000081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173027000082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027000083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173027000084 dimerization interface [polypeptide binding]; other site 1173027000085 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1173027000086 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1173027000087 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1173027000088 catalytic site [active] 1173027000089 G-X2-G-X-G-K; other site 1173027000090 hypothetical protein; Provisional; Region: PRK04323 1173027000091 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1173027000092 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1173027000093 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173027000094 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027000095 Walker A/P-loop; other site 1173027000096 ATP binding site [chemical binding]; other site 1173027000097 Q-loop/lid; other site 1173027000098 ABC transporter signature motif; other site 1173027000099 Walker B; other site 1173027000100 D-loop; other site 1173027000101 H-loop/switch region; other site 1173027000102 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173027000103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027000104 dimer interface [polypeptide binding]; other site 1173027000105 conserved gate region; other site 1173027000106 putative PBP binding loops; other site 1173027000107 ABC-ATPase subunit interface; other site 1173027000108 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173027000109 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173027000110 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1173027000111 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 1173027000112 hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100 1173027000113 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1173027000114 agmatinase; Region: agmatinase; TIGR01230 1173027000115 Agmatinase-like family; Region: Agmatinase-like; cd09990 1173027000116 active site 1173027000117 oligomer interface [polypeptide binding]; other site 1173027000118 Mn binding site [ion binding]; other site 1173027000119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027000120 TPR motif; other site 1173027000121 binding surface 1173027000122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173027000123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173027000124 Walker A/P-loop; other site 1173027000125 ATP binding site [chemical binding]; other site 1173027000126 Q-loop/lid; other site 1173027000127 ABC transporter signature motif; other site 1173027000128 Walker B; other site 1173027000129 D-loop; other site 1173027000130 H-loop/switch region; other site 1173027000131 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1173027000132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000133 S-adenosylmethionine binding site [chemical binding]; other site 1173027000134 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173027000135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027000136 active site 1173027000137 catalytic tetrad [active] 1173027000138 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1173027000139 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027000140 active site 1173027000141 dimer interface [polypeptide binding]; other site 1173027000142 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027000143 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173027000144 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1173027000145 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1173027000146 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173027000147 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1173027000148 RNA binding site [nucleotide binding]; other site 1173027000149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000151 S-adenosylmethionine binding site [chemical binding]; other site 1173027000152 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1173027000153 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1173027000154 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1173027000155 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1173027000156 putative active site [active] 1173027000157 putative substrate binding site [chemical binding]; other site 1173027000158 putative cosubstrate binding site; other site 1173027000159 catalytic site [active] 1173027000160 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1173027000161 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173027000162 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1173027000163 Mg++ binding site [ion binding]; other site 1173027000164 putative catalytic motif [active] 1173027000165 substrate binding site [chemical binding]; other site 1173027000166 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 1173027000167 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173027000168 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173027000169 putative active site [active] 1173027000170 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173027000171 putative active site [active] 1173027000172 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1173027000173 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1173027000174 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 1173027000175 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1173027000176 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173027000177 Rubredoxin; Region: Rubredoxin; pfam00301 1173027000178 iron binding site [ion binding]; other site 1173027000179 Ycf48-like protein; Provisional; Region: PRK13684 1173027000180 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 1173027000181 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 1173027000182 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1173027000183 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 1173027000184 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 1173027000185 PsbJ; Region: PsbJ; pfam01788 1173027000186 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1173027000187 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173027000188 dimer interface [polypeptide binding]; other site 1173027000189 motif 1; other site 1173027000190 active site 1173027000191 motif 2; other site 1173027000192 motif 3; other site 1173027000193 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1173027000194 anticodon binding site; other site 1173027000195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173027000196 MORN repeat; Region: MORN; cl14787 1173027000197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173027000198 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173027000199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027000200 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027000201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027000202 DNA binding residues [nucleotide binding] 1173027000203 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 1173027000204 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173027000205 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173027000206 active site 1173027000207 substrate binding site [chemical binding]; other site 1173027000208 metal binding site [ion binding]; metal-binding site 1173027000209 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1173027000210 active site 1173027000211 dimerization interface [polypeptide binding]; other site 1173027000212 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1173027000213 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1173027000214 Double zinc ribbon; Region: DZR; pfam12773 1173027000215 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1173027000216 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1173027000217 active site 1173027000218 catalytic site [active] 1173027000219 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027000220 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027000221 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027000222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000223 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1173027000224 putative ADP-binding pocket [chemical binding]; other site 1173027000225 Bacterial sugar transferase; Region: Bac_transf; cl00939 1173027000226 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027000227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027000228 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173027000229 Walker A/P-loop; other site 1173027000230 ATP binding site [chemical binding]; other site 1173027000231 Q-loop/lid; other site 1173027000232 ABC transporter signature motif; other site 1173027000233 Walker B; other site 1173027000234 D-loop; other site 1173027000235 H-loop/switch region; other site 1173027000236 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027000237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027000238 active site 1173027000239 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027000240 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027000241 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027000242 active site 1173027000243 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027000244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027000245 active site 1173027000246 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000247 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027000248 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027000249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027000250 active site 1173027000251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027000252 O-Antigen ligase; Region: Wzy_C; pfam04932 1173027000253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000254 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027000255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000256 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027000257 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1173027000258 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1173027000259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027000260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000262 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027000263 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027000264 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027000265 putative active site [active] 1173027000266 Caspase domain; Region: Peptidase_C14; pfam00656 1173027000267 GUN4-like; Region: GUN4; pfam05419 1173027000268 Domain of unknown function DUF59; Region: DUF59; pfam01883 1173027000269 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1173027000270 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1173027000271 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1173027000272 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 1173027000273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027000274 Probable transposase; Region: OrfB_IS605; pfam01385 1173027000275 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027000276 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173027000277 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173027000278 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173027000279 Ligand Binding Site [chemical binding]; other site 1173027000280 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027000281 Ligand Binding Site [chemical binding]; other site 1173027000282 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 1173027000283 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173027000284 active site 1173027000285 HIGH motif; other site 1173027000286 nucleotide binding site [chemical binding]; other site 1173027000287 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173027000288 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173027000289 active site 1173027000290 KMSKS motif; other site 1173027000291 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1173027000292 tRNA binding surface [nucleotide binding]; other site 1173027000293 anticodon binding site; other site 1173027000294 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1173027000295 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173027000296 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1173027000297 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173027000298 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1173027000299 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 1173027000300 Predicted membrane protein [Function unknown]; Region: COG3431 1173027000301 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1173027000302 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1173027000303 [4Fe-4S] binding site [ion binding]; other site 1173027000304 molybdopterin cofactor binding site; other site 1173027000305 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1173027000306 molybdopterin cofactor binding site; other site 1173027000307 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1173027000308 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027000309 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027000310 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1173027000311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027000312 putative substrate translocation pore; other site 1173027000313 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027000314 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173027000315 Walker A/P-loop; other site 1173027000316 ATP binding site [chemical binding]; other site 1173027000317 Q-loop/lid; other site 1173027000318 ABC transporter signature motif; other site 1173027000319 Walker B; other site 1173027000320 D-loop; other site 1173027000321 H-loop/switch region; other site 1173027000322 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027000323 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173027000324 Walker A/P-loop; other site 1173027000325 ATP binding site [chemical binding]; other site 1173027000326 Q-loop/lid; other site 1173027000327 ABC transporter signature motif; other site 1173027000328 Walker B; other site 1173027000329 D-loop; other site 1173027000330 H-loop/switch region; other site 1173027000331 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027000332 NMT1-like family; Region: NMT1_2; pfam13379 1173027000333 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173027000334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027000335 dimer interface [polypeptide binding]; other site 1173027000336 conserved gate region; other site 1173027000337 putative PBP binding loops; other site 1173027000338 ABC-ATPase subunit interface; other site 1173027000339 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027000340 NMT1-like family; Region: NMT1_2; pfam13379 1173027000341 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1173027000342 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027000343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027000344 HEAT repeats; Region: HEAT_2; pfam13646 1173027000345 HEAT repeats; Region: HEAT_2; pfam13646 1173027000346 HEAT repeats; Region: HEAT_2; pfam13646 1173027000347 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173027000348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027000349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027000350 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173027000351 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1173027000352 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173027000353 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173027000354 active site 1173027000355 putative phosphoketolase; Provisional; Region: PRK05261 1173027000356 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173027000357 TPP-binding site; other site 1173027000358 XFP C-terminal domain; Region: XFP_C; pfam09363 1173027000359 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1173027000360 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027000361 putative C-terminal domain interface [polypeptide binding]; other site 1173027000362 putative GSH binding site [chemical binding]; other site 1173027000363 putative dimer interface [polypeptide binding]; other site 1173027000364 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1173027000365 putative N-terminal domain interface [polypeptide binding]; other site 1173027000366 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1173027000367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027000368 putative substrate translocation pore; other site 1173027000369 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1173027000370 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173027000371 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173027000372 DNA binding residues [nucleotide binding] 1173027000373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1173027000374 DinB superfamily; Region: DinB_2; pfam12867 1173027000375 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027000376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000377 S-adenosylmethionine binding site [chemical binding]; other site 1173027000378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027000379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027000380 active site 1173027000381 catalytic tetrad [active] 1173027000382 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173027000383 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173027000384 Catalytic site [active] 1173027000385 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1173027000386 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173027000387 inhibitor-cofactor binding pocket; inhibition site 1173027000388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027000389 catalytic residue [active] 1173027000390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027000391 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027000392 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173027000393 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173027000394 trimer interface [polypeptide binding]; other site 1173027000395 active site 1173027000396 substrate binding site [chemical binding]; other site 1173027000397 CoA binding site [chemical binding]; other site 1173027000398 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000400 S-adenosylmethionine binding site [chemical binding]; other site 1173027000401 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173027000402 YwiC-like protein; Region: YwiC; pfam14256 1173027000403 HEPN domain; Region: HEPN; cl00824 1173027000404 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027000405 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027000406 active site 1173027000407 Isochorismatase family; Region: Isochorismatase; pfam00857 1173027000408 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173027000409 catalytic triad [active] 1173027000410 conserved cis-peptide bond; other site 1173027000411 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173027000412 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000413 GAF domain; Region: GAF; pfam01590 1173027000414 PAS domain; Region: PAS; smart00091 1173027000415 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027000416 putative active site [active] 1173027000417 heme pocket [chemical binding]; other site 1173027000418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000419 dimer interface [polypeptide binding]; other site 1173027000420 phosphorylation site [posttranslational modification] 1173027000421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000422 ATP binding site [chemical binding]; other site 1173027000423 Mg2+ binding site [ion binding]; other site 1173027000424 G-X-G motif; other site 1173027000425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027000426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027000427 ligand binding site [chemical binding]; other site 1173027000428 flexible hinge region; other site 1173027000429 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000430 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027000431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000432 putative active site [active] 1173027000433 heme pocket [chemical binding]; other site 1173027000434 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027000435 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027000436 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027000437 ligand binding site [chemical binding]; other site 1173027000438 flexible hinge region; other site 1173027000439 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027000440 CHASE2 domain; Region: CHASE2; pfam05226 1173027000441 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027000442 cyclase homology domain; Region: CHD; cd07302 1173027000443 nucleotidyl binding site; other site 1173027000444 metal binding site [ion binding]; metal-binding site 1173027000445 dimer interface [polypeptide binding]; other site 1173027000446 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027000447 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1173027000448 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1173027000449 substrate binding site [chemical binding]; other site 1173027000450 active site 1173027000451 catalytic residues [active] 1173027000452 heterodimer interface [polypeptide binding]; other site 1173027000453 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 1173027000454 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027000455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000456 S-adenosylmethionine binding site [chemical binding]; other site 1173027000457 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027000458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027000459 active site 1173027000460 ATP binding site [chemical binding]; other site 1173027000461 substrate binding site [chemical binding]; other site 1173027000462 activation loop (A-loop); other site 1173027000463 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1173027000464 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027000465 structural tetrad; other site 1173027000466 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027000467 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027000468 structural tetrad; other site 1173027000469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000470 PAS fold; Region: PAS_3; pfam08447 1173027000471 putative active site [active] 1173027000472 heme pocket [chemical binding]; other site 1173027000473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173027000474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000475 dimer interface [polypeptide binding]; other site 1173027000476 phosphorylation site [posttranslational modification] 1173027000477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000478 ATP binding site [chemical binding]; other site 1173027000479 Mg2+ binding site [ion binding]; other site 1173027000480 G-X-G motif; other site 1173027000481 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027000482 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027000483 active site 1173027000484 ATP binding site [chemical binding]; other site 1173027000485 substrate binding site [chemical binding]; other site 1173027000486 activation loop (A-loop); other site 1173027000487 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173027000488 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1173027000489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027000490 active site 1173027000491 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173027000492 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173027000493 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173027000494 Transporter associated domain; Region: CorC_HlyC; smart01091 1173027000495 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027000496 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027000497 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027000498 active site 1173027000499 ATP binding site [chemical binding]; other site 1173027000500 substrate binding site [chemical binding]; other site 1173027000501 activation loop (A-loop); other site 1173027000502 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1173027000503 Ligand Binding Site [chemical binding]; other site 1173027000504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173027000505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173027000506 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173027000507 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1173027000508 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1173027000509 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173027000510 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027000511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173027000512 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1173027000513 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173027000514 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173027000515 Walker A/P-loop; other site 1173027000516 ATP binding site [chemical binding]; other site 1173027000517 Q-loop/lid; other site 1173027000518 ABC transporter signature motif; other site 1173027000519 Walker B; other site 1173027000520 D-loop; other site 1173027000521 H-loop/switch region; other site 1173027000522 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173027000523 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173027000524 Walker A/P-loop; other site 1173027000525 ATP binding site [chemical binding]; other site 1173027000526 Q-loop/lid; other site 1173027000527 ABC transporter signature motif; other site 1173027000528 Walker B; other site 1173027000529 D-loop; other site 1173027000530 H-loop/switch region; other site 1173027000531 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173027000532 TM-ABC transporter signature motif; other site 1173027000533 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027000534 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173027000535 TM-ABC transporter signature motif; other site 1173027000536 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173027000537 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1173027000538 dimerization interface [polypeptide binding]; other site 1173027000539 ligand binding site [chemical binding]; other site 1173027000540 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027000541 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173027000542 putative ADP-binding pocket [chemical binding]; other site 1173027000543 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027000544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027000545 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1173027000546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027000547 non-specific DNA binding site [nucleotide binding]; other site 1173027000548 salt bridge; other site 1173027000549 sequence-specific DNA binding site [nucleotide binding]; other site 1173027000550 LabA_like proteins; Region: LabA_like; cd06167 1173027000551 putative metal binding site [ion binding]; other site 1173027000552 alanine racemase; Reviewed; Region: alr; PRK00053 1173027000553 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1173027000554 active site 1173027000555 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173027000556 dimer interface [polypeptide binding]; other site 1173027000557 substrate binding site [chemical binding]; other site 1173027000558 catalytic residues [active] 1173027000559 adhesin; Provisional; Region: PRK09752 1173027000560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1173027000561 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1173027000562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027000563 cyclic 3',5'-adenosine monophosphate phosphodiesterase; Provisional; Region: PRK11148 1173027000564 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1173027000565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027000566 Coenzyme A binding pocket [chemical binding]; other site 1173027000567 Tic22-like family; Region: Tic22; pfam04278 1173027000568 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1173027000569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027000570 S-adenosylmethionine binding site [chemical binding]; other site 1173027000571 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1173027000572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027000573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000574 dimer interface [polypeptide binding]; other site 1173027000575 phosphorylation site [posttranslational modification] 1173027000576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027000577 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173027000578 Coenzyme A binding pocket [chemical binding]; other site 1173027000579 Predicted membrane protein [Function unknown]; Region: COG4270 1173027000580 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1173027000581 dimer interface [polypeptide binding]; other site 1173027000582 active site 1173027000583 Schiff base residues; other site 1173027000584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027000585 dimerization interface [polypeptide binding]; other site 1173027000586 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027000587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000588 putative active site [active] 1173027000589 heme pocket [chemical binding]; other site 1173027000590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000591 dimer interface [polypeptide binding]; other site 1173027000592 phosphorylation site [posttranslational modification] 1173027000593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000594 ATP binding site [chemical binding]; other site 1173027000595 Mg2+ binding site [ion binding]; other site 1173027000596 G-X-G motif; other site 1173027000597 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000599 active site 1173027000600 phosphorylation site [posttranslational modification] 1173027000601 intermolecular recognition site; other site 1173027000602 dimerization interface [polypeptide binding]; other site 1173027000603 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027000604 cyclase homology domain; Region: CHD; cd07302 1173027000605 nucleotidyl binding site; other site 1173027000606 metal binding site [ion binding]; metal-binding site 1173027000607 dimer interface [polypeptide binding]; other site 1173027000608 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1173027000609 ribosomal protein L21; Region: rpl21; CHL00075 1173027000610 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1173027000611 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173027000612 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173027000613 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173027000614 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1173027000615 active site 1173027000616 catalytic residues [active] 1173027000617 TIGR03943 family protein; Region: TIGR03943 1173027000618 Predicted permeases [General function prediction only]; Region: COG0701 1173027000619 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173027000620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027000621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000622 ATP binding site [chemical binding]; other site 1173027000623 Mg2+ binding site [ion binding]; other site 1173027000624 G-X-G motif; other site 1173027000625 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1173027000626 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027000627 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027000628 catalytic residues [active] 1173027000629 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1173027000630 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1173027000631 active site 1173027000632 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1173027000633 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1173027000634 tetrameric interface [polypeptide binding]; other site 1173027000635 NAD binding site [chemical binding]; other site 1173027000636 catalytic residues [active] 1173027000637 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027000638 G1 box; other site 1173027000639 GTP/Mg2+ binding site [chemical binding]; other site 1173027000640 G3 box; other site 1173027000641 Switch II region; other site 1173027000642 G4 box; other site 1173027000643 G5 box; other site 1173027000644 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173027000645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027000646 non-specific DNA binding site [nucleotide binding]; other site 1173027000647 salt bridge; other site 1173027000648 sequence-specific DNA binding site [nucleotide binding]; other site 1173027000649 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173027000650 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1173027000651 Cl- selectivity filter; other site 1173027000652 Cl- binding residues [ion binding]; other site 1173027000653 pore gating glutamate residue; other site 1173027000654 dimer interface [polypeptide binding]; other site 1173027000655 DNA gyrase subunit A; Validated; Region: PRK05560 1173027000656 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173027000657 CAP-like domain; other site 1173027000658 active site 1173027000659 primary dimer interface [polypeptide binding]; other site 1173027000660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027000666 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173027000667 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173027000668 putative active site [active] 1173027000669 catalytic triad [active] 1173027000670 putative dimer interface [polypeptide binding]; other site 1173027000671 Tic20-like protein; Region: Tic20; pfam09685 1173027000672 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173027000673 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1173027000674 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027000675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027000676 non-specific DNA binding site [nucleotide binding]; other site 1173027000677 salt bridge; other site 1173027000678 sequence-specific DNA binding site [nucleotide binding]; other site 1173027000679 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1173027000680 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 1173027000681 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1173027000682 MoaE homodimer interface [polypeptide binding]; other site 1173027000683 MoaD interaction [polypeptide binding]; other site 1173027000684 active site residues [active] 1173027000685 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000686 GAF domain; Region: GAF; pfam01590 1173027000687 PAS domain S-box; Region: sensory_box; TIGR00229 1173027000688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000689 putative active site [active] 1173027000690 heme pocket [chemical binding]; other site 1173027000691 PAS fold; Region: PAS_4; pfam08448 1173027000692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000693 putative active site [active] 1173027000694 heme pocket [chemical binding]; other site 1173027000695 PAS domain S-box; Region: sensory_box; TIGR00229 1173027000696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000697 putative active site [active] 1173027000698 heme pocket [chemical binding]; other site 1173027000699 PAS domain S-box; Region: sensory_box; TIGR00229 1173027000700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000701 putative active site [active] 1173027000702 heme pocket [chemical binding]; other site 1173027000703 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000704 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027000705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000706 dimer interface [polypeptide binding]; other site 1173027000707 phosphorylation site [posttranslational modification] 1173027000708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000709 ATP binding site [chemical binding]; other site 1173027000710 Mg2+ binding site [ion binding]; other site 1173027000711 G-X-G motif; other site 1173027000712 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000714 active site 1173027000715 phosphorylation site [posttranslational modification] 1173027000716 intermolecular recognition site; other site 1173027000717 dimerization interface [polypeptide binding]; other site 1173027000718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027000719 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000721 dimer interface [polypeptide binding]; other site 1173027000722 phosphorylation site [posttranslational modification] 1173027000723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000724 ATP binding site [chemical binding]; other site 1173027000725 Mg2+ binding site [ion binding]; other site 1173027000726 G-X-G motif; other site 1173027000727 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000729 active site 1173027000730 phosphorylation site [posttranslational modification] 1173027000731 intermolecular recognition site; other site 1173027000732 dimerization interface [polypeptide binding]; other site 1173027000733 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000735 active site 1173027000736 phosphorylation site [posttranslational modification] 1173027000737 intermolecular recognition site; other site 1173027000738 dimerization interface [polypeptide binding]; other site 1173027000739 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027000740 putative binding surface; other site 1173027000741 active site 1173027000742 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000744 active site 1173027000745 phosphorylation site [posttranslational modification] 1173027000746 intermolecular recognition site; other site 1173027000747 dimerization interface [polypeptide binding]; other site 1173027000748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000749 PAS fold; Region: PAS_3; pfam08447 1173027000750 putative active site [active] 1173027000751 heme pocket [chemical binding]; other site 1173027000752 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000753 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027000754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000755 dimer interface [polypeptide binding]; other site 1173027000756 phosphorylation site [posttranslational modification] 1173027000757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000758 ATP binding site [chemical binding]; other site 1173027000759 Mg2+ binding site [ion binding]; other site 1173027000760 G-X-G motif; other site 1173027000761 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027000762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000763 active site 1173027000764 phosphorylation site [posttranslational modification] 1173027000765 intermolecular recognition site; other site 1173027000766 dimerization interface [polypeptide binding]; other site 1173027000767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000768 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173027000769 putative active site [active] 1173027000770 heme pocket [chemical binding]; other site 1173027000771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000772 dimer interface [polypeptide binding]; other site 1173027000773 phosphorylation site [posttranslational modification] 1173027000774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000775 ATP binding site [chemical binding]; other site 1173027000776 Mg2+ binding site [ion binding]; other site 1173027000777 G-X-G motif; other site 1173027000778 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000780 active site 1173027000781 phosphorylation site [posttranslational modification] 1173027000782 intermolecular recognition site; other site 1173027000783 dimerization interface [polypeptide binding]; other site 1173027000784 Family description; Region: UvrD_C_2; pfam13538 1173027000785 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027000786 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027000787 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027000788 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173027000789 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173027000790 G1 box; other site 1173027000791 GTP/Mg2+ binding site [chemical binding]; other site 1173027000792 Switch I region; other site 1173027000793 G2 box; other site 1173027000794 Switch II region; other site 1173027000795 G3 box; other site 1173027000796 G4 box; other site 1173027000797 G5 box; other site 1173027000798 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173027000799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027000800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027000801 dimer interface [polypeptide binding]; other site 1173027000802 phosphorylation site [posttranslational modification] 1173027000803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027000804 ATP binding site [chemical binding]; other site 1173027000805 Mg2+ binding site [ion binding]; other site 1173027000806 G-X-G motif; other site 1173027000807 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000809 active site 1173027000810 phosphorylation site [posttranslational modification] 1173027000811 intermolecular recognition site; other site 1173027000812 dimerization interface [polypeptide binding]; other site 1173027000813 KaiA domain; Region: KaiA; pfam07688 1173027000814 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027000815 tetramer interface [polypeptide binding]; other site 1173027000816 dimer interface [polypeptide binding]; other site 1173027000817 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 1173027000818 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 1173027000819 Walker A motif; other site 1173027000820 ATP binding site [chemical binding]; other site 1173027000821 Walker B motif; other site 1173027000822 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027000823 ATP binding site [chemical binding]; other site 1173027000824 Walker B motif; other site 1173027000825 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173027000826 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1173027000827 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1173027000828 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1173027000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027000830 Walker A motif; other site 1173027000831 ATP binding site [chemical binding]; other site 1173027000832 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1173027000833 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1173027000834 Walker A/P-loop; other site 1173027000835 ATP binding site [chemical binding]; other site 1173027000836 Q-loop/lid; other site 1173027000837 ABC transporter signature motif; other site 1173027000838 Walker B; other site 1173027000839 D-loop; other site 1173027000840 H-loop/switch region; other site 1173027000841 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1173027000842 mce related protein; Region: MCE; pfam02470 1173027000843 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 1173027000844 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173027000845 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1173027000846 MOSC domain; Region: MOSC; pfam03473 1173027000847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027000848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027000849 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1173027000850 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027000851 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000852 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000853 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000854 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000855 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173027000856 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 1173027000857 Rab subfamily motif 1 (RabSF1); other site 1173027000858 G1 box; other site 1173027000859 GTP/Mg2+ binding site [chemical binding]; other site 1173027000860 Rab subfamily motif 2 (RabSF2); other site 1173027000861 Switch I region; other site 1173027000862 G2 box; other site 1173027000863 effector interaction site; other site 1173027000864 GDI interaction site; other site 1173027000865 Rab family motif 1 (RabF1); other site 1173027000866 GEF interaction site [polypeptide binding]; other site 1173027000867 Rab family motif 2 (RabF2); other site 1173027000868 G3 box; other site 1173027000869 Switch II region; other site 1173027000870 Rab family motif 3 (RabF3); other site 1173027000871 Rab family motif 4 (RabF4); other site 1173027000872 Rab family motif 5 (RabF5); other site 1173027000873 Rab subfamily motif 3 (RabSF3); other site 1173027000874 G4 box; other site 1173027000875 G5 box; other site 1173027000876 PAS domain S-box; Region: sensory_box; TIGR00229 1173027000877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027000878 putative active site [active] 1173027000879 heme pocket [chemical binding]; other site 1173027000880 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027000881 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027000882 phosphopeptide binding site; other site 1173027000883 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027000884 putative active site [active] 1173027000885 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173027000886 proline aminopeptidase P II; Provisional; Region: PRK10879 1173027000887 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173027000888 active site 1173027000889 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027000890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000892 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027000893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000894 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000898 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027000899 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000900 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000901 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000902 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027000903 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000904 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027000905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027000906 active site 1173027000907 phosphorylation site [posttranslational modification] 1173027000908 intermolecular recognition site; other site 1173027000909 dimerization interface [polypeptide binding]; other site 1173027000910 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 1173027000911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000912 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027000913 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027000914 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173027000915 metal binding site 2 [ion binding]; metal-binding site 1173027000916 putative DNA binding helix; other site 1173027000917 metal binding site 1 [ion binding]; metal-binding site 1173027000918 dimer interface [polypeptide binding]; other site 1173027000919 structural Zn2+ binding site [ion binding]; other site 1173027000920 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1173027000921 AAA domain; Region: AAA_17; cl17253 1173027000922 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173027000923 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027000924 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027000925 structural tetrad; other site 1173027000926 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1173027000927 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173027000928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173027000929 Divalent cation transporter; Region: MgtE; pfam01769 1173027000930 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1173027000931 putative NAD(P) binding site [chemical binding]; other site 1173027000932 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173027000933 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1173027000934 catalytic residues [active] 1173027000935 dimer interface [polypeptide binding]; other site 1173027000936 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173027000937 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173027000938 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 1173027000939 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027000940 putative active site [active] 1173027000941 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 1173027000942 conserved hypothetical protein; Region: TIGR02231 1173027000943 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1173027000944 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173027000945 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1173027000946 FAD binding site [chemical binding]; other site 1173027000947 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1173027000948 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1173027000949 active site 1173027000950 HIGH motif; other site 1173027000951 dimer interface [polypeptide binding]; other site 1173027000952 KMSKS motif; other site 1173027000953 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 1173027000954 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1173027000955 MPT binding site; other site 1173027000956 trimer interface [polypeptide binding]; other site 1173027000957 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 1173027000958 active site 1173027000959 catalytic triad [active] 1173027000960 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1173027000961 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173027000962 C-terminal peptidase (prc); Region: prc; TIGR00225 1173027000963 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173027000964 protein binding site [polypeptide binding]; other site 1173027000965 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173027000966 Catalytic dyad [active] 1173027000967 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027000968 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027000969 putative active site [active] 1173027000970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027000971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027000972 ligand binding site [chemical binding]; other site 1173027000973 flexible hinge region; other site 1173027000974 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1173027000975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027000976 Walker A motif; other site 1173027000977 ATP binding site [chemical binding]; other site 1173027000978 Walker B motif; other site 1173027000979 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1173027000980 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173027000981 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173027000982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027000983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027000984 active site 1173027000985 ATP binding site [chemical binding]; other site 1173027000986 substrate binding site [chemical binding]; other site 1173027000987 activation loop (A-loop); other site 1173027000988 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027000989 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027000990 phosphopeptide binding site; other site 1173027000991 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027000992 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027000993 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027000994 cyclase homology domain; Region: CHD; cd07302 1173027000995 nucleotidyl binding site; other site 1173027000996 metal binding site [ion binding]; metal-binding site 1173027000997 dimer interface [polypeptide binding]; other site 1173027000998 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173027000999 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1173027001000 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173027001001 DHH family; Region: DHH; pfam01368 1173027001002 DHHA1 domain; Region: DHHA1; pfam02272 1173027001003 Thioredoxin; Region: Thioredoxin_4; pfam13462 1173027001004 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1173027001005 HAMP domain; Region: HAMP; pfam00672 1173027001006 dimerization interface [polypeptide binding]; other site 1173027001007 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027001008 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027001009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027001010 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027001011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027001012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027001013 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027001014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027001015 dimer interface [polypeptide binding]; other site 1173027001016 putative CheW interface [polypeptide binding]; other site 1173027001017 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027001018 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1173027001019 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027001020 choline dehydrogenase; Validated; Region: PRK02106 1173027001021 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1173027001022 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1173027001023 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1173027001024 Putative esterase; Region: Esterase; pfam00756 1173027001025 HAS barrel domain; Region: HAS-barrel; pfam09378 1173027001026 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173027001027 AAA-like domain; Region: AAA_10; pfam12846 1173027001028 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027001029 putative active site [active] 1173027001030 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027001031 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001035 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001037 RNA polymerase sigma factor; Validated; Region: PRK05949 1173027001038 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173027001039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027001040 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027001041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027001042 DNA binding residues [nucleotide binding] 1173027001043 ribonuclease E; Reviewed; Region: rne; PRK10811 1173027001044 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1173027001045 transketolase; Region: PLN02790 1173027001046 TPP-binding site [chemical binding]; other site 1173027001047 dimer interface [polypeptide binding]; other site 1173027001048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173027001049 PYR/PP interface [polypeptide binding]; other site 1173027001050 dimer interface [polypeptide binding]; other site 1173027001051 TPP binding site [chemical binding]; other site 1173027001052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173027001053 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1173027001054 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173027001055 dimer interface [polypeptide binding]; other site 1173027001056 active site 1173027001057 acyl carrier protein; Provisional; Region: acpP; PRK00982 1173027001058 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1173027001059 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1173027001060 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1173027001061 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1173027001062 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 1173027001063 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027001064 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027001065 phosphopeptide binding site; other site 1173027001066 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027001067 cyclase homology domain; Region: CHD; cd07302 1173027001068 nucleotidyl binding site; other site 1173027001069 metal binding site [ion binding]; metal-binding site 1173027001070 dimer interface [polypeptide binding]; other site 1173027001071 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 1173027001072 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173027001073 30S subunit binding site; other site 1173027001074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027001075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027001077 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173027001078 putative substrate translocation pore; other site 1173027001079 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1173027001080 Recombination protein O N terminal; Region: RecO_N; pfam11967 1173027001081 Recombination protein O C terminal; Region: RecO_C; pfam02565 1173027001082 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1173027001083 intersubunit interface [polypeptide binding]; other site 1173027001084 active site 1173027001085 catalytic residue [active] 1173027001086 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1173027001087 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1173027001088 metal binding site [ion binding]; metal-binding site 1173027001089 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173027001090 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173027001091 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173027001092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173027001093 ABC-ATPase subunit interface; other site 1173027001094 dimer interface [polypeptide binding]; other site 1173027001095 putative PBP binding regions; other site 1173027001096 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1173027001097 active site 1173027001098 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1173027001099 phosphoglyceromutase; Provisional; Region: PRK05434 1173027001100 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 1173027001101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027001102 FeS/SAM binding site; other site 1173027001103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027001104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027001105 DNA binding residues [nucleotide binding] 1173027001106 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 1173027001107 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027001108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027001109 DNA binding residues [nucleotide binding] 1173027001110 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173027001111 protein I interface; other site 1173027001112 D2 interface; other site 1173027001113 protein T interface; other site 1173027001114 chlorophyll binding site; other site 1173027001115 beta carotene binding site; other site 1173027001116 pheophytin binding site; other site 1173027001117 manganese-stabilizing polypeptide interface; other site 1173027001118 CP43 interface; other site 1173027001119 protein L interface; other site 1173027001120 oxygen evolving complex binding site; other site 1173027001121 bromide binding site; other site 1173027001122 quinone binding site; other site 1173027001123 Fe binding site [ion binding]; other site 1173027001124 core light harvesting interface; other site 1173027001125 cytochrome b559 alpha subunit interface; other site 1173027001126 cytochrome c-550 interface; other site 1173027001127 protein J interface; other site 1173027001128 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1173027001129 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1173027001130 Tetramer interface [polypeptide binding]; other site 1173027001131 active site 1173027001132 FMN-binding site [chemical binding]; other site 1173027001133 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173027001134 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1173027001135 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1173027001136 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1173027001137 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1173027001138 trimerization site [polypeptide binding]; other site 1173027001139 active site 1173027001140 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1173027001141 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173027001142 Ligand binding site; other site 1173027001143 metal-binding site 1173027001144 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1173027001145 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1173027001146 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1173027001147 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1173027001148 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173027001149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173027001150 Walker A/P-loop; other site 1173027001151 ATP binding site [chemical binding]; other site 1173027001152 Q-loop/lid; other site 1173027001153 ABC transporter signature motif; other site 1173027001154 Walker B; other site 1173027001155 D-loop; other site 1173027001156 H-loop/switch region; other site 1173027001157 DevC protein; Region: devC; TIGR01185 1173027001158 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027001159 FtsX-like permease family; Region: FtsX; pfam02687 1173027001160 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173027001161 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173027001162 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027001163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027001164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027001165 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 1173027001166 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1173027001167 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1173027001168 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1173027001169 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1173027001170 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1173027001171 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1173027001172 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1173027001173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027001174 catalytic loop [active] 1173027001175 iron binding site [ion binding]; other site 1173027001176 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1173027001177 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1173027001178 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1173027001179 Walker A/P-loop; other site 1173027001180 ATP binding site [chemical binding]; other site 1173027001181 Q-loop/lid; other site 1173027001182 ABC transporter signature motif; other site 1173027001183 Walker B; other site 1173027001184 D-loop; other site 1173027001185 H-loop/switch region; other site 1173027001186 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1173027001187 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1173027001188 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173027001189 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173027001190 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1173027001191 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027001192 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173027001193 C-terminal domain interface [polypeptide binding]; other site 1173027001194 GSH binding site (G-site) [chemical binding]; other site 1173027001195 dimer interface [polypeptide binding]; other site 1173027001196 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173027001197 N-terminal domain interface [polypeptide binding]; other site 1173027001198 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027001199 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173027001200 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173027001201 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173027001202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027001203 Walker A motif; other site 1173027001204 ATP binding site [chemical binding]; other site 1173027001205 Walker B motif; other site 1173027001206 arginine finger; other site 1173027001207 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173027001208 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027001209 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001210 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001211 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001212 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173027001213 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027001214 putative metal binding site; other site 1173027001215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001216 TPR motif; other site 1173027001217 binding surface 1173027001218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001219 TPR repeat; Region: TPR_11; pfam13414 1173027001220 binding surface 1173027001221 TPR motif; other site 1173027001222 TPR repeat; Region: TPR_11; pfam13414 1173027001223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001224 binding surface 1173027001225 TPR motif; other site 1173027001226 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 1173027001227 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 1173027001228 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173027001229 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1173027001230 active site 1173027001231 catalytic triad [active] 1173027001232 oxyanion hole [active] 1173027001233 AAA ATPase domain; Region: AAA_16; pfam13191 1173027001234 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027001235 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1173027001236 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1173027001237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027001238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027001239 DNA binding residues [nucleotide binding] 1173027001240 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173027001241 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027001242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001243 dimerization interface [polypeptide binding]; other site 1173027001244 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027001245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001246 dimerization interface [polypeptide binding]; other site 1173027001247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001248 dimerization interface [polypeptide binding]; other site 1173027001249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001250 dimerization interface [polypeptide binding]; other site 1173027001251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001252 dimerization interface [polypeptide binding]; other site 1173027001253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001254 dimerization interface [polypeptide binding]; other site 1173027001255 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027001256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001257 dimerization interface [polypeptide binding]; other site 1173027001258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001259 dimerization interface [polypeptide binding]; other site 1173027001260 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027001261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001262 dimerization interface [polypeptide binding]; other site 1173027001263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001264 dimerization interface [polypeptide binding]; other site 1173027001265 HAMP domain; Region: HAMP; pfam00672 1173027001266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027001267 dimerization interface [polypeptide binding]; other site 1173027001268 GAF domain; Region: GAF_2; pfam13185 1173027001269 GAF domain; Region: GAF; pfam01590 1173027001270 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1173027001271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027001272 ATP binding site [chemical binding]; other site 1173027001273 Mg2+ binding site [ion binding]; other site 1173027001274 G-X-G motif; other site 1173027001275 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027001276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001277 active site 1173027001278 phosphorylation site [posttranslational modification] 1173027001279 intermolecular recognition site; other site 1173027001280 dimerization interface [polypeptide binding]; other site 1173027001281 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027001282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001283 active site 1173027001284 phosphorylation site [posttranslational modification] 1173027001285 intermolecular recognition site; other site 1173027001286 dimerization interface [polypeptide binding]; other site 1173027001287 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027001288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001289 active site 1173027001290 phosphorylation site [posttranslational modification] 1173027001291 intermolecular recognition site; other site 1173027001292 dimerization interface [polypeptide binding]; other site 1173027001293 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173027001294 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173027001295 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173027001296 CheB methylesterase; Region: CheB_methylest; pfam01339 1173027001297 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027001298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001299 active site 1173027001300 phosphorylation site [posttranslational modification] 1173027001301 intermolecular recognition site; other site 1173027001302 dimerization interface [polypeptide binding]; other site 1173027001303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027001304 PAS fold; Region: PAS; pfam00989 1173027001305 putative active site [active] 1173027001306 heme pocket [chemical binding]; other site 1173027001307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027001308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027001309 dimer interface [polypeptide binding]; other site 1173027001310 phosphorylation site [posttranslational modification] 1173027001311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027001312 ATP binding site [chemical binding]; other site 1173027001313 Mg2+ binding site [ion binding]; other site 1173027001314 G-X-G motif; other site 1173027001315 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027001316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001317 active site 1173027001318 phosphorylation site [posttranslational modification] 1173027001319 intermolecular recognition site; other site 1173027001320 dimerization interface [polypeptide binding]; other site 1173027001321 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173027001322 active site 1173027001323 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173027001324 DHH family; Region: DHH; pfam01368 1173027001325 DHHA1 domain; Region: DHHA1; pfam02272 1173027001326 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 1173027001327 Flagellin N-methylase; Region: FliB; pfam03692 1173027001328 Predicted membrane protein [Function unknown]; Region: COG2119 1173027001329 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173027001330 Predicted membrane protein [Function unknown]; Region: COG2119 1173027001331 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173027001332 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173027001333 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173027001334 Walker A motif; other site 1173027001335 ATP binding site [chemical binding]; other site 1173027001336 Walker B motif; other site 1173027001337 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027001338 phosphopeptide binding site; other site 1173027001339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 1173027001340 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027001341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001342 AAA ATPase domain; Region: AAA_16; pfam13191 1173027001343 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027001344 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001345 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001346 structural tetrad; other site 1173027001347 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001348 structural tetrad; other site 1173027001349 WD40 repeats; Region: WD40; smart00320 1173027001350 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1173027001351 Caspase domain; Region: Peptidase_C14; pfam00656 1173027001352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001353 binding surface 1173027001354 TPR motif; other site 1173027001355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001358 binding surface 1173027001359 TPR motif; other site 1173027001360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001363 binding surface 1173027001364 TPR motif; other site 1173027001365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001367 binding surface 1173027001368 TPR motif; other site 1173027001369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001372 binding surface 1173027001373 TPR motif; other site 1173027001374 CHAT domain; Region: CHAT; pfam12770 1173027001375 AAA ATPase domain; Region: AAA_16; pfam13191 1173027001376 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027001377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001378 structural tetrad; other site 1173027001379 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001380 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001381 structural tetrad; other site 1173027001382 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1173027001383 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027001384 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027001385 P-loop; other site 1173027001386 Magnesium ion binding site [ion binding]; other site 1173027001387 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027001388 Magnesium ion binding site [ion binding]; other site 1173027001389 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 1173027001390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027001391 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027001392 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 1173027001393 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1173027001394 active site 1173027001395 ATP-binding site [chemical binding]; other site 1173027001396 pantoate-binding site; other site 1173027001397 HXXH motif; other site 1173027001398 AAA domain; Region: AAA_17; pfam13207 1173027001399 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1173027001400 CMP-binding site; other site 1173027001401 The sites determining sugar specificity; other site 1173027001402 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173027001403 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173027001404 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1173027001405 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1173027001406 dimerization interface [polypeptide binding]; other site 1173027001407 putative ATP binding site [chemical binding]; other site 1173027001408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173027001409 MarR family; Region: MarR_2; cl17246 1173027001410 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1173027001411 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027001412 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173027001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027001414 putative substrate translocation pore; other site 1173027001415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027001416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027001417 putative substrate translocation pore; other site 1173027001418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027001419 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027001420 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173027001421 MarR family; Region: MarR_2; cl17246 1173027001422 Putative transcription activator [Transcription]; Region: TenA; COG0819 1173027001423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1173027001424 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1173027001425 PRC-barrel domain; Region: PRC; pfam05239 1173027001426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173027001427 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1173027001428 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1173027001429 active site 1173027001430 intersubunit interface [polypeptide binding]; other site 1173027001431 catalytic residue [active] 1173027001432 RRXRR protein; Region: RRXRR; pfam14239 1173027001433 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1173027001434 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1173027001435 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027001436 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173027001437 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173027001438 Ligand binding site; other site 1173027001439 Putative Catalytic site; other site 1173027001440 DXD motif; other site 1173027001441 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1173027001442 amidase catalytic site [active] 1173027001443 Zn binding residues [ion binding]; other site 1173027001444 substrate binding site [chemical binding]; other site 1173027001445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001446 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001447 Conserved TM helix; Region: TM_helix; pfam05552 1173027001448 Conserved TM helix; Region: TM_helix; pfam05552 1173027001449 Conserved TM helix; Region: TM_helix; pfam05552 1173027001450 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1173027001451 hydrophobic ligand binding site; other site 1173027001452 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1173027001453 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1173027001454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027001455 binding surface 1173027001456 TPR motif; other site 1173027001457 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027001458 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027001459 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001460 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001461 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001462 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 1173027001463 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 1173027001464 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 1173027001465 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173027001466 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173027001467 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027001468 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1173027001469 substrate binding site; other site 1173027001470 dimer interface; other site 1173027001471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027001472 S-adenosylmethionine binding site [chemical binding]; other site 1173027001473 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1173027001474 Active_site [active] 1173027001475 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1173027001476 Group XII secretory phospholipase A2 precursor (PLA2G12); Region: PLA2G12; pfam06951 1173027001477 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1173027001478 active site 1173027001479 nucleophile elbow; other site 1173027001480 AAA ATPase domain; Region: AAA_16; pfam13191 1173027001481 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001482 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001483 structural tetrad; other site 1173027001484 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001485 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001486 structural tetrad; other site 1173027001487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027001488 phosphopeptide binding site; other site 1173027001489 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027001490 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027001491 phosphopeptide binding site; other site 1173027001492 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173027001493 HEAT repeats; Region: HEAT_2; pfam13646 1173027001494 protein binding surface [polypeptide binding]; other site 1173027001495 Dynamin family; Region: Dynamin_N; pfam00350 1173027001496 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173027001497 G1 box; other site 1173027001498 GTP/Mg2+ binding site [chemical binding]; other site 1173027001499 Switch I region; other site 1173027001500 G2 box; other site 1173027001501 Switch II region; other site 1173027001502 G3 box; other site 1173027001503 G4 box; other site 1173027001504 G5 box; other site 1173027001505 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173027001506 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 1173027001507 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 1173027001508 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1173027001509 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027001510 catalytic residues [active] 1173027001511 NHL repeat; Region: NHL; pfam01436 1173027001512 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027001513 tetramer interface [polypeptide binding]; other site 1173027001514 dimer interface [polypeptide binding]; other site 1173027001515 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173027001516 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173027001517 Walker A motif; other site 1173027001518 ATP binding site [chemical binding]; other site 1173027001519 Walker B motif; other site 1173027001520 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1173027001521 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173027001522 active site 1173027001523 homodimer interface [polypeptide binding]; other site 1173027001524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001525 binding surface 1173027001526 TPR motif; other site 1173027001527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001530 binding surface 1173027001531 TPR motif; other site 1173027001532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001534 binding surface 1173027001535 TPR motif; other site 1173027001536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001538 binding surface 1173027001539 TPR motif; other site 1173027001540 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001543 binding surface 1173027001544 TPR motif; other site 1173027001545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001548 binding surface 1173027001549 TPR motif; other site 1173027001550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001551 CHAT domain; Region: CHAT; pfam12770 1173027001552 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 1173027001553 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027001554 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 1173027001555 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173027001556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027001557 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1173027001558 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027001559 catalytic residues [active] 1173027001560 Predicted membrane protein [Function unknown]; Region: COG4094 1173027001561 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1173027001562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027001563 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1173027001564 putative dimerization interface [polypeptide binding]; other site 1173027001565 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027001566 active site 1173027001567 ATP binding site [chemical binding]; other site 1173027001568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027001569 substrate binding site [chemical binding]; other site 1173027001570 activation loop (A-loop); other site 1173027001571 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173027001572 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 1173027001573 putative ligand binding site [chemical binding]; other site 1173027001574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173027001575 dimerization interface [polypeptide binding]; other site 1173027001576 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027001577 putative active site [active] 1173027001578 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027001579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027001580 active site 1173027001581 KGK domain; Region: KGK; pfam08872 1173027001582 KGK domain; Region: KGK; pfam08872 1173027001583 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1173027001584 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027001585 G1 box; other site 1173027001586 GTP/Mg2+ binding site [chemical binding]; other site 1173027001587 G2 box; other site 1173027001588 Switch I region; other site 1173027001589 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027001590 G3 box; other site 1173027001591 Switch II region; other site 1173027001592 G4 box; other site 1173027001593 amino acid transporter; Region: 2A0306; TIGR00909 1173027001594 ParG; Region: ParG; pfam09274 1173027001595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027001596 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1173027001597 FeS/SAM binding site; other site 1173027001598 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1173027001599 Zn binding site [ion binding]; other site 1173027001600 toxin interface [polypeptide binding]; other site 1173027001601 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027001602 ABC1 family; Region: ABC1; pfam03109 1173027001603 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173027001604 active site 1173027001605 ATP binding site [chemical binding]; other site 1173027001606 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1173027001607 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1173027001608 Substrate binding site; other site 1173027001609 Cupin domain; Region: Cupin_2; cl17218 1173027001610 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173027001611 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173027001612 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027001613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001614 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001615 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 1173027001616 active site 1173027001617 catalytic triad [active] 1173027001618 oxyanion hole [active] 1173027001619 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 1173027001620 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 1173027001621 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027001622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027001623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027001624 Pirin-related protein [General function prediction only]; Region: COG1741 1173027001625 Pirin; Region: Pirin; pfam02678 1173027001626 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173027001627 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173027001628 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173027001629 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173027001630 active site 1173027001631 putative substrate binding region [chemical binding]; other site 1173027001632 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027001633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1173027001634 2TM domain; Region: 2TM; pfam13239 1173027001635 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1173027001636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001638 binding surface 1173027001639 TPR motif; other site 1173027001640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001643 binding surface 1173027001644 TPR motif; other site 1173027001645 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027001646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173027001647 active site 1173027001648 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1173027001649 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1173027001650 dimer interface [polypeptide binding]; other site 1173027001651 putative anticodon binding site; other site 1173027001652 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1173027001653 motif 1; other site 1173027001654 active site 1173027001655 motif 2; other site 1173027001656 motif 3; other site 1173027001657 KTSC domain; Region: KTSC; pfam13619 1173027001658 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1173027001659 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001660 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173027001661 trimer interface [polypeptide binding]; other site 1173027001662 active site 1173027001663 substrate binding site [chemical binding]; other site 1173027001664 CoA binding site [chemical binding]; other site 1173027001665 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1173027001666 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027001667 Chain length determinant protein; Region: Wzz; pfam02706 1173027001668 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173027001669 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027001670 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027001671 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027001672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027001673 active site 1173027001674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027001675 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027001676 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173027001677 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1173027001678 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027001679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027001680 active site 1173027001681 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173027001682 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173027001683 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1173027001684 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027001685 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1173027001686 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173027001687 catalytic triad [active] 1173027001688 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173027001689 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173027001690 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173027001691 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173027001692 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 1173027001693 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 1173027001694 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027001695 putative ADP-binding pocket [chemical binding]; other site 1173027001696 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1173027001697 homotrimer interaction site [polypeptide binding]; other site 1173027001698 zinc binding site [ion binding]; other site 1173027001699 CDP-binding sites; other site 1173027001700 PAS domain S-box; Region: sensory_box; TIGR00229 1173027001701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027001702 putative active site [active] 1173027001703 heme pocket [chemical binding]; other site 1173027001704 PAS domain S-box; Region: sensory_box; TIGR00229 1173027001705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027001706 putative active site [active] 1173027001707 heme pocket [chemical binding]; other site 1173027001708 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027001709 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027001710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027001711 dimer interface [polypeptide binding]; other site 1173027001712 phosphorylation site [posttranslational modification] 1173027001713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027001714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027001715 ATP binding site [chemical binding]; other site 1173027001716 G-X-G motif; other site 1173027001717 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1173027001718 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173027001719 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173027001720 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173027001721 catalytic motif [active] 1173027001722 Catalytic residue [active] 1173027001723 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1173027001724 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1173027001725 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1173027001726 catalytic site [active] 1173027001727 subunit interface [polypeptide binding]; other site 1173027001728 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173027001729 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173027001730 anti sigma factor interaction site; other site 1173027001731 regulatory phosphorylation site [posttranslational modification]; other site 1173027001732 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173027001733 dimerization interface [polypeptide binding]; other site 1173027001734 active site 1173027001735 metal binding site [ion binding]; metal-binding site 1173027001736 Rubella capsid protein; Region: Rubella_Capsid; pfam05750 1173027001737 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1173027001738 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1173027001739 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173027001740 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173027001741 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027001742 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173027001743 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1173027001744 GIY-YIG motif/motif A; other site 1173027001745 active site 1173027001746 catalytic site [active] 1173027001747 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173027001748 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173027001749 von Willebrand factor type D domain; Region: VWD; cl02516 1173027001750 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173027001751 AAA ATPase domain; Region: AAA_16; pfam13191 1173027001752 NACHT domain; Region: NACHT; pfam05729 1173027001753 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027001754 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001755 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027001756 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001757 structural tetrad; other site 1173027001758 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027001759 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027001760 structural tetrad; other site 1173027001761 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173027001762 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1173027001763 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 1173027001764 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1173027001765 active site 1173027001766 PHP Thumb interface [polypeptide binding]; other site 1173027001767 metal binding site [ion binding]; metal-binding site 1173027001768 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173027001769 protein-splicing catalytic site; other site 1173027001770 thioester formation/cholesterol transfer; other site 1173027001771 TM2 domain; Region: TM2; cl00984 1173027001772 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027001773 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173027001774 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1173027001775 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027001776 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1173027001777 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1173027001778 PemK-like protein; Region: PemK; pfam02452 1173027001779 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173027001780 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1173027001781 active site 1173027001782 NTP binding site [chemical binding]; other site 1173027001783 nucleic acid binding site [nucleotide binding]; other site 1173027001784 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1173027001785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027001786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027001787 salt bridge; other site 1173027001788 non-specific DNA binding site [nucleotide binding]; other site 1173027001789 sequence-specific DNA binding site [nucleotide binding]; other site 1173027001790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027001791 salt bridge; other site 1173027001792 non-specific DNA binding site [nucleotide binding]; other site 1173027001793 sequence-specific DNA binding site [nucleotide binding]; other site 1173027001794 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027001795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027001796 non-specific DNA binding site [nucleotide binding]; other site 1173027001797 salt bridge; other site 1173027001798 sequence-specific DNA binding site [nucleotide binding]; other site 1173027001799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173027001800 sequence-specific DNA binding site [nucleotide binding]; other site 1173027001801 salt bridge; other site 1173027001802 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173027001803 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173027001804 B12 binding site [chemical binding]; other site 1173027001805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027001806 FeS/SAM binding site; other site 1173027001807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 1173027001808 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1173027001809 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173027001810 anti sigma factor interaction site; other site 1173027001811 regulatory phosphorylation site [posttranslational modification]; other site 1173027001812 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027001813 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027001814 ligand binding site [chemical binding]; other site 1173027001815 flexible hinge region; other site 1173027001816 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1173027001817 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027001818 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173027001819 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1173027001820 putative NAD(P) binding site [chemical binding]; other site 1173027001821 PAS domain S-box; Region: sensory_box; TIGR00229 1173027001822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027001823 putative active site [active] 1173027001824 heme pocket [chemical binding]; other site 1173027001825 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173027001826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027001827 putative active site [active] 1173027001828 heme pocket [chemical binding]; other site 1173027001829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027001830 dimer interface [polypeptide binding]; other site 1173027001831 phosphorylation site [posttranslational modification] 1173027001832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027001833 ATP binding site [chemical binding]; other site 1173027001834 Mg2+ binding site [ion binding]; other site 1173027001835 G-X-G motif; other site 1173027001836 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 1173027001837 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1173027001838 putative valine binding site [chemical binding]; other site 1173027001839 dimer interface [polypeptide binding]; other site 1173027001840 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1173027001841 outer membrane lipoprotein; Provisional; Region: PRK11023 1173027001842 BON domain; Region: BON; pfam04972 1173027001843 S-layer homology domain; Region: SLH; pfam00395 1173027001844 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027001845 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027001846 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173027001847 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1173027001848 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173027001849 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173027001850 TLC ATP/ADP transporter; Region: TLC; cl03940 1173027001851 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027001852 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027001853 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027001854 ligand binding site [chemical binding]; other site 1173027001855 flexible hinge region; other site 1173027001856 GAF domain; Region: GAF; pfam01590 1173027001857 GAF domain; Region: GAF_2; pfam13185 1173027001858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027001859 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 1173027001860 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1173027001861 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1173027001862 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027001863 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027001864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027001865 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027001866 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027001867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027001868 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1173027001869 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173027001870 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173027001871 Walker A/P-loop; other site 1173027001872 ATP binding site [chemical binding]; other site 1173027001873 Q-loop/lid; other site 1173027001874 ABC transporter signature motif; other site 1173027001875 Walker B; other site 1173027001876 D-loop; other site 1173027001877 H-loop/switch region; other site 1173027001878 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1173027001879 Family description; Region: UvrD_C_2; pfam13538 1173027001880 TPR repeat; Region: TPR_11; pfam13414 1173027001881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001882 binding surface 1173027001883 TPR motif; other site 1173027001884 TPR repeat; Region: TPR_11; pfam13414 1173027001885 TPR repeat; Region: TPR_11; pfam13414 1173027001886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001887 binding surface 1173027001888 TPR motif; other site 1173027001889 TPR repeat; Region: TPR_11; pfam13414 1173027001890 TPR repeat; Region: TPR_11; pfam13414 1173027001891 Repair protein; Region: Repair_PSII; pfam04536 1173027001892 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1173027001893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027001894 catalytic residue [active] 1173027001895 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1173027001896 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173027001897 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1173027001898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1173027001899 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173027001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027001901 S-adenosylmethionine binding site [chemical binding]; other site 1173027001902 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027001903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027001904 active site 1173027001905 phosphorylation site [posttranslational modification] 1173027001906 intermolecular recognition site; other site 1173027001907 dimerization interface [polypeptide binding]; other site 1173027001908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027001909 GAF domain; Region: GAF_3; pfam13492 1173027001910 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 1173027001911 ATP adenylyltransferase; Region: ATP_transf; pfam09830 1173027001912 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173027001913 metal binding site [ion binding]; metal-binding site 1173027001914 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027001915 Dynamin family; Region: Dynamin_N; pfam00350 1173027001916 G1 box; other site 1173027001917 GTP/Mg2+ binding site [chemical binding]; other site 1173027001918 G2 box; other site 1173027001919 Switch I region; other site 1173027001920 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173027001921 G3 box; other site 1173027001922 Switch II region; other site 1173027001923 GTP/Mg2+ binding site [chemical binding]; other site 1173027001924 G4 box; other site 1173027001925 G5 box; other site 1173027001926 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173027001927 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1173027001928 ThiS interaction site; other site 1173027001929 putative active site [active] 1173027001930 tetramer interface [polypeptide binding]; other site 1173027001931 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173027001932 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173027001933 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173027001934 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173027001935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027001936 FeS/SAM binding site; other site 1173027001937 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173027001938 HD domain; Region: HD_5; pfam13487 1173027001939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001940 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027001941 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027001942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001944 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027001945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001946 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027001947 CAAX protease self-immunity; Region: Abi; pfam02517 1173027001948 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1173027001949 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173027001950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173027001951 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173027001952 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173027001953 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173027001954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173027001955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027001956 Coenzyme A binding pocket [chemical binding]; other site 1173027001957 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173027001958 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173027001959 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173027001960 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1173027001961 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173027001962 active site 1173027001963 putative substrate binding region [chemical binding]; other site 1173027001964 TPR repeat; Region: TPR_11; pfam13414 1173027001965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001966 binding surface 1173027001967 TPR motif; other site 1173027001968 TPR repeat; Region: TPR_11; pfam13414 1173027001969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027001970 TPR repeat; Region: TPR_11; pfam13414 1173027001971 binding surface 1173027001972 TPR motif; other site 1173027001973 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027001974 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027001975 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1173027001976 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1173027001977 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1173027001978 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1173027001979 HIGH motif; other site 1173027001980 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173027001981 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173027001982 active site 1173027001983 KMSKS motif; other site 1173027001984 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1173027001985 tRNA binding surface [nucleotide binding]; other site 1173027001986 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173027001987 putative active site pocket [active] 1173027001988 dimerization interface [polypeptide binding]; other site 1173027001989 putative catalytic residue [active] 1173027001990 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173027001991 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1173027001992 homodimer interface [polypeptide binding]; other site 1173027001993 substrate-cofactor binding pocket; other site 1173027001994 catalytic residue [active] 1173027001995 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1173027001996 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1173027001997 active site 1173027001998 dimer interface [polypeptide binding]; other site 1173027001999 metal binding site [ion binding]; metal-binding site 1173027002000 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1173027002001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002002 Walker A/P-loop; other site 1173027002003 ATP binding site [chemical binding]; other site 1173027002004 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002005 putative active site [active] 1173027002006 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002007 putative active site [active] 1173027002008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027002009 non-specific DNA binding site [nucleotide binding]; other site 1173027002010 salt bridge; other site 1173027002011 sequence-specific DNA binding site [nucleotide binding]; other site 1173027002012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027002013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027002014 active site 1173027002015 ATP binding site [chemical binding]; other site 1173027002016 substrate binding site [chemical binding]; other site 1173027002017 activation loop (A-loop); other site 1173027002018 TPR repeat; Region: TPR_11; pfam13414 1173027002019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002020 binding surface 1173027002021 TPR motif; other site 1173027002022 TPR repeat; Region: TPR_11; pfam13414 1173027002023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002024 binding surface 1173027002025 TPR motif; other site 1173027002026 TPR repeat; Region: TPR_11; pfam13414 1173027002027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173027002028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173027002029 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027002030 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027002031 active site 1173027002032 ATP binding site [chemical binding]; other site 1173027002033 substrate binding site [chemical binding]; other site 1173027002034 activation loop (A-loop); other site 1173027002035 TPR repeat; Region: TPR_11; pfam13414 1173027002036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002037 TPR motif; other site 1173027002038 binding surface 1173027002039 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027002040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002041 binding surface 1173027002042 TPR motif; other site 1173027002043 TPR repeat; Region: TPR_11; pfam13414 1173027002044 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173027002045 amidohydrolase; Region: amidohydrolases; TIGR01891 1173027002046 metal binding site [ion binding]; metal-binding site 1173027002047 dimer interface [polypeptide binding]; other site 1173027002048 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1173027002049 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027002050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027002051 S-adenosylmethionine binding site [chemical binding]; other site 1173027002052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027002053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002054 Walker A/P-loop; other site 1173027002055 ATP binding site [chemical binding]; other site 1173027002056 Q-loop/lid; other site 1173027002057 ABC transporter signature motif; other site 1173027002058 Walker B; other site 1173027002059 D-loop; other site 1173027002060 H-loop/switch region; other site 1173027002061 Inward rectifier potassium channel; Region: IRK; pfam01007 1173027002062 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1173027002063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002064 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002065 active site 1173027002066 phosphorylation site [posttranslational modification] 1173027002067 intermolecular recognition site; other site 1173027002068 dimerization interface [polypeptide binding]; other site 1173027002069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027002070 dimer interface [polypeptide binding]; other site 1173027002071 phosphorylation site [posttranslational modification] 1173027002072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002073 ATP binding site [chemical binding]; other site 1173027002074 Mg2+ binding site [ion binding]; other site 1173027002075 G-X-G motif; other site 1173027002076 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002078 active site 1173027002079 phosphorylation site [posttranslational modification] 1173027002080 intermolecular recognition site; other site 1173027002081 dimerization interface [polypeptide binding]; other site 1173027002082 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027002083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002084 putative active site [active] 1173027002085 heme pocket [chemical binding]; other site 1173027002086 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027002087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002088 putative active site [active] 1173027002089 heme pocket [chemical binding]; other site 1173027002090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002091 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027002092 putative active site [active] 1173027002093 heme pocket [chemical binding]; other site 1173027002094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002095 putative active site [active] 1173027002096 heme pocket [chemical binding]; other site 1173027002097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002098 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027002100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002101 dimer interface [polypeptide binding]; other site 1173027002102 phosphorylation site [posttranslational modification] 1173027002103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002104 ATP binding site [chemical binding]; other site 1173027002105 Mg2+ binding site [ion binding]; other site 1173027002106 G-X-G motif; other site 1173027002107 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027002108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002109 active site 1173027002110 phosphorylation site [posttranslational modification] 1173027002111 intermolecular recognition site; other site 1173027002112 dimerization interface [polypeptide binding]; other site 1173027002113 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173027002114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027002115 Walker A motif; other site 1173027002116 ATP binding site [chemical binding]; other site 1173027002117 Walker B motif; other site 1173027002118 arginine finger; other site 1173027002119 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173027002120 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173027002121 homodimer interface [polypeptide binding]; other site 1173027002122 substrate-cofactor binding pocket; other site 1173027002123 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1173027002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027002125 catalytic residue [active] 1173027002126 CHASE domain; Region: CHASE; cl01369 1173027002127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002128 dimer interface [polypeptide binding]; other site 1173027002129 phosphorylation site [posttranslational modification] 1173027002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002131 ATP binding site [chemical binding]; other site 1173027002132 Mg2+ binding site [ion binding]; other site 1173027002133 G-X-G motif; other site 1173027002134 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002136 active site 1173027002137 phosphorylation site [posttranslational modification] 1173027002138 intermolecular recognition site; other site 1173027002139 dimerization interface [polypeptide binding]; other site 1173027002140 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027002141 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 1173027002143 Uncharacterized conserved protein [Function unknown]; Region: COG5439 1173027002144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002145 PAS domain; Region: PAS_9; pfam13426 1173027002146 putative active site [active] 1173027002147 heme pocket [chemical binding]; other site 1173027002148 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027002149 cyclase homology domain; Region: CHD; cd07302 1173027002150 nucleotidyl binding site; other site 1173027002151 metal binding site [ion binding]; metal-binding site 1173027002152 dimer interface [polypeptide binding]; other site 1173027002153 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1173027002154 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1173027002155 23S rRNA binding site [nucleotide binding]; other site 1173027002156 L21 binding site [polypeptide binding]; other site 1173027002157 L13 binding site [polypeptide binding]; other site 1173027002158 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173027002159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173027002160 substrate binding pocket [chemical binding]; other site 1173027002161 membrane-bound complex binding site; other site 1173027002162 hinge residues; other site 1173027002163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002164 binding surface 1173027002165 TPR repeat; Region: TPR_11; pfam13414 1173027002166 TPR motif; other site 1173027002167 TPR repeat; Region: TPR_11; pfam13414 1173027002168 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1173027002169 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1173027002170 purine monophosphate binding site [chemical binding]; other site 1173027002171 dimer interface [polypeptide binding]; other site 1173027002172 putative catalytic residues [active] 1173027002173 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1173027002174 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1173027002175 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 1173027002176 Photosystem I reaction centre subunit III; Region: PSI_PsaF; pfam02507 1173027002177 UGMP family protein; Validated; Region: PRK09604 1173027002178 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1173027002179 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1173027002180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027002181 GAF domain; Region: GAF; pfam01590 1173027002182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027002183 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173027002184 NAD(P) binding site [chemical binding]; other site 1173027002185 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1173027002186 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173027002187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027002188 active site 1173027002189 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173027002190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027002191 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027002192 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027002193 DNA binding residues [nucleotide binding] 1173027002194 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1173027002195 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 1173027002196 metal-binding heat shock protein; Provisional; Region: PRK00016 1173027002197 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1173027002198 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1173027002199 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1173027002200 glutamine binding [chemical binding]; other site 1173027002201 catalytic triad [active] 1173027002202 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173027002203 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173027002204 GAF domain; Region: GAF_2; pfam13185 1173027002205 GAF domain; Region: GAF_3; pfam13492 1173027002206 Heme NO binding associated; Region: HNOBA; pfam07701 1173027002207 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027002208 cyclase homology domain; Region: CHD; cd07302 1173027002209 nucleotidyl binding site; other site 1173027002210 metal binding site [ion binding]; metal-binding site 1173027002211 dimer interface [polypeptide binding]; other site 1173027002212 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1173027002213 proline aminopeptidase P II; Provisional; Region: PRK10879 1173027002214 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173027002215 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173027002216 active site 1173027002217 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1173027002218 CsbD-like; Region: CsbD; cl17424 1173027002219 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173027002220 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002221 putative active site [active] 1173027002222 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002223 putative active site [active] 1173027002224 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1173027002225 catalytic triad [active] 1173027002226 conserved cis-peptide bond; other site 1173027002227 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1173027002228 Putative esterase; Region: Esterase; pfam00756 1173027002229 hypothetical protein; Validated; Region: PRK07413 1173027002230 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1173027002231 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173027002232 Walker A motif; other site 1173027002233 homodimer interface [polypeptide binding]; other site 1173027002234 ATP binding site [chemical binding]; other site 1173027002235 hydroxycobalamin binding site [chemical binding]; other site 1173027002236 Walker B motif; other site 1173027002237 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1173027002238 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1173027002239 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1173027002240 Ligand Binding Site [chemical binding]; other site 1173027002241 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173027002242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027002243 Walker A/P-loop; other site 1173027002244 ATP binding site [chemical binding]; other site 1173027002245 Q-loop/lid; other site 1173027002246 ABC transporter signature motif; other site 1173027002247 Walker B; other site 1173027002248 D-loop; other site 1173027002249 H-loop/switch region; other site 1173027002250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173027002251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027002252 Walker A/P-loop; other site 1173027002253 ATP binding site [chemical binding]; other site 1173027002254 Q-loop/lid; other site 1173027002255 ABC transporter signature motif; other site 1173027002256 Walker B; other site 1173027002257 D-loop; other site 1173027002258 H-loop/switch region; other site 1173027002259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173027002260 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173027002261 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027002262 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027002263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027002264 Walker A motif; other site 1173027002265 ATP binding site [chemical binding]; other site 1173027002266 Walker B motif; other site 1173027002267 arginine finger; other site 1173027002268 UvrB/uvrC motif; Region: UVR; pfam02151 1173027002269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027002270 Walker A motif; other site 1173027002271 ATP binding site [chemical binding]; other site 1173027002272 Walker B motif; other site 1173027002273 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173027002274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002275 binding surface 1173027002276 TPR motif; other site 1173027002277 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027002278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002279 binding surface 1173027002280 TPR motif; other site 1173027002281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002282 binding surface 1173027002283 TPR motif; other site 1173027002284 AAA ATPase domain; Region: AAA_16; pfam13191 1173027002285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002286 TPR motif; other site 1173027002287 TPR repeat; Region: TPR_11; pfam13414 1173027002288 binding surface 1173027002289 TPR repeat; Region: TPR_11; pfam13414 1173027002290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002291 TPR motif; other site 1173027002292 binding surface 1173027002293 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027002294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002295 binding surface 1173027002296 TPR motif; other site 1173027002297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002298 binding surface 1173027002299 TPR motif; other site 1173027002300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002301 binding surface 1173027002302 TPR motif; other site 1173027002303 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1173027002304 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1173027002305 motif 1; other site 1173027002306 active site 1173027002307 motif 2; other site 1173027002308 motif 3; other site 1173027002309 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173027002310 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1173027002311 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1173027002312 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173027002313 putative active site [active] 1173027002314 putative NTP binding site [chemical binding]; other site 1173027002315 putative nucleic acid binding site [nucleotide binding]; other site 1173027002316 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173027002317 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027002318 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027002319 active site 1173027002320 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1173027002321 metal-binding site [ion binding] 1173027002322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027002323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027002324 metal binding site [ion binding]; metal-binding site 1173027002325 active site 1173027002326 I-site; other site 1173027002327 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173027002328 Predicted permeases [General function prediction only]; Region: COG0679 1173027002329 XisI protein; Region: XisI; pfam08869 1173027002330 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1173027002331 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027002332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027002333 active site 1173027002334 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173027002335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027002336 putative substrate translocation pore; other site 1173027002337 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173027002338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027002339 putative ADP-binding pocket [chemical binding]; other site 1173027002340 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173027002341 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173027002342 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1173027002343 S-layer homology domain; Region: SLH; pfam00395 1173027002344 S-layer homology domain; Region: SLH; pfam00395 1173027002345 HEAT repeats; Region: HEAT_2; pfam13646 1173027002346 HEAT repeats; Region: HEAT_2; pfam13646 1173027002347 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027002348 CpeS-like protein; Region: CpeS; pfam09367 1173027002349 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027002350 metal binding site [ion binding]; metal-binding site 1173027002351 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173027002352 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027002353 PGAP1-like protein; Region: PGAP1; pfam07819 1173027002354 ChaB; Region: ChaB; pfam06150 1173027002355 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1173027002356 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1173027002357 ligand binding site [chemical binding]; other site 1173027002358 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1173027002359 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1173027002360 putative active site [active] 1173027002361 substrate binding site [chemical binding]; other site 1173027002362 putative cosubstrate binding site; other site 1173027002363 catalytic site [active] 1173027002364 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1173027002365 substrate binding site [chemical binding]; other site 1173027002366 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027002367 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002368 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002369 photosystem I subunit VII; Region: psaC; CHL00065 1173027002370 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027002371 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1173027002372 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1173027002373 glutaminase active site [active] 1173027002374 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1173027002375 dimer interface [polypeptide binding]; other site 1173027002376 active site 1173027002377 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1173027002378 dimer interface [polypeptide binding]; other site 1173027002379 active site 1173027002380 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173027002381 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1173027002382 Integrase core domain; Region: rve; pfam00665 1173027002383 AAA domain; Region: AAA_22; pfam13401 1173027002384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173027002385 Walker A motif; other site 1173027002386 ATP binding site [chemical binding]; other site 1173027002387 Walker B motif; other site 1173027002388 TniQ; Region: TniQ; pfam06527 1173027002389 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173027002390 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1173027002391 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1173027002392 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1173027002393 Protein of unknown function DUF45; Region: DUF45; pfam01863 1173027002394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027002395 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027002396 active site 1173027002397 ATP binding site [chemical binding]; other site 1173027002398 substrate binding site [chemical binding]; other site 1173027002399 activation loop (A-loop); other site 1173027002400 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027002401 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027002402 phosphopeptide binding site; other site 1173027002403 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027002404 phosphopeptide binding site; other site 1173027002405 CHAT domain; Region: CHAT; pfam12770 1173027002406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027002407 non-specific DNA binding site [nucleotide binding]; other site 1173027002408 salt bridge; other site 1173027002409 sequence-specific DNA binding site [nucleotide binding]; other site 1173027002410 TniQ; Region: TniQ; pfam06527 1173027002411 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1173027002412 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1173027002413 Caspase domain; Region: Peptidase_C14; pfam00656 1173027002414 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027002415 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027002416 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1173027002417 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173027002418 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173027002419 nucleotide binding site [chemical binding]; other site 1173027002420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173027002421 nucleotide binding site [chemical binding]; other site 1173027002422 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027002423 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002424 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002426 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002428 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002429 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027002431 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173027002432 active site 1173027002433 metal binding site [ion binding]; metal-binding site 1173027002434 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1173027002435 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1173027002436 active site 1173027002437 substrate-binding site [chemical binding]; other site 1173027002438 metal-binding site [ion binding] 1173027002439 ATP binding site [chemical binding]; other site 1173027002440 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027002441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027002442 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1173027002443 MutS domain III; Region: MutS_III; pfam05192 1173027002444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002445 Walker A/P-loop; other site 1173027002446 ATP binding site [chemical binding]; other site 1173027002447 Q-loop/lid; other site 1173027002448 ABC transporter signature motif; other site 1173027002449 Walker B; other site 1173027002450 D-loop; other site 1173027002451 H-loop/switch region; other site 1173027002452 Smr domain; Region: Smr; pfam01713 1173027002453 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173027002454 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173027002455 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173027002456 yiaA/B two helix domain; Region: YiaAB; cl01759 1173027002457 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1173027002458 Ycf35; Provisional; Region: ycf35; CHL00193 1173027002459 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1173027002460 homoserine dehydrogenase; Provisional; Region: PRK06270 1173027002461 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1173027002462 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173027002463 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173027002464 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173027002465 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173027002466 Walker A motif; other site 1173027002467 ATP binding site [chemical binding]; other site 1173027002468 Walker B motif; other site 1173027002469 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173027002470 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173027002471 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173027002472 Walker A motif; other site 1173027002473 ATP binding site [chemical binding]; other site 1173027002474 Walker B motif; other site 1173027002475 GrpE; Region: GrpE; pfam01025 1173027002476 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173027002477 dimer interface [polypeptide binding]; other site 1173027002478 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173027002479 molecular chaperone DnaK; Provisional; Region: PRK13411 1173027002480 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173027002481 nucleotide binding site [chemical binding]; other site 1173027002482 NEF interaction site [polypeptide binding]; other site 1173027002483 SBD interface [polypeptide binding]; other site 1173027002484 chaperone protein DnaJ; Provisional; Region: PRK14293 1173027002485 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027002486 HSP70 interaction site [polypeptide binding]; other site 1173027002487 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1173027002488 substrate binding site [polypeptide binding]; other site 1173027002489 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1173027002490 Zn binding sites [ion binding]; other site 1173027002491 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173027002492 dimer interface [polypeptide binding]; other site 1173027002493 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1173027002494 CPxP motif; other site 1173027002495 GTPase RsgA; Reviewed; Region: PRK12289 1173027002496 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173027002497 RNA binding site [nucleotide binding]; other site 1173027002498 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1173027002499 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1173027002500 GTP/Mg2+ binding site [chemical binding]; other site 1173027002501 G4 box; other site 1173027002502 G5 box; other site 1173027002503 G1 box; other site 1173027002504 Switch I region; other site 1173027002505 G2 box; other site 1173027002506 G3 box; other site 1173027002507 Switch II region; other site 1173027002508 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1173027002509 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002511 active site 1173027002512 phosphorylation site [posttranslational modification] 1173027002513 intermolecular recognition site; other site 1173027002514 dimerization interface [polypeptide binding]; other site 1173027002515 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173027002516 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1173027002517 active site 1173027002518 PUCC protein; Region: PUCC; pfam03209 1173027002519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027002520 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027002521 active site 1173027002522 catalytic tetrad [active] 1173027002523 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1173027002524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173027002525 substrate binding site [chemical binding]; other site 1173027002526 ATP binding site [chemical binding]; other site 1173027002527 Predicted methyltransferases [General function prediction only]; Region: COG0313 1173027002528 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1173027002529 putative SAM binding site [chemical binding]; other site 1173027002530 putative homodimer interface [polypeptide binding]; other site 1173027002531 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1173027002532 active site 1173027002533 dimerization interface [polypeptide binding]; other site 1173027002534 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1173027002535 Two component regulator propeller; Region: Reg_prop; pfam07494 1173027002536 Two component regulator propeller; Region: Reg_prop; pfam07494 1173027002537 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1173027002538 PAS fold; Region: PAS_4; pfam08448 1173027002539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002540 putative active site [active] 1173027002541 heme pocket [chemical binding]; other site 1173027002542 PAS domain S-box; Region: sensory_box; TIGR00229 1173027002543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173027002544 Histidine kinase; Region: HisKA_2; pfam07568 1173027002545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002546 ATP binding site [chemical binding]; other site 1173027002547 Mg2+ binding site [ion binding]; other site 1173027002548 G-X-G motif; other site 1173027002549 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173027002550 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173027002551 putative FMN binding site [chemical binding]; other site 1173027002552 NADPH bind site [chemical binding]; other site 1173027002553 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173027002554 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1173027002555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027002556 Coenzyme A binding pocket [chemical binding]; other site 1173027002557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173027002558 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173027002559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027002560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027002561 active site 1173027002562 ATP binding site [chemical binding]; other site 1173027002563 substrate binding site [chemical binding]; other site 1173027002564 activation loop (A-loop); other site 1173027002565 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027002566 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027002567 structural tetrad; other site 1173027002568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027002569 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173027002570 Probable transposase; Region: OrfB_IS605; pfam01385 1173027002571 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027002572 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173027002573 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173027002574 S-layer homology domain; Region: SLH; pfam00395 1173027002575 S-layer homology domain; Region: SLH; pfam00395 1173027002576 S-layer homology domain; Region: SLH; pfam00395 1173027002577 S-layer homology domain; Region: SLH; pfam00395 1173027002578 S-layer homology domain; Region: SLH; pfam00395 1173027002579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027002580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002581 Walker A/P-loop; other site 1173027002582 ATP binding site [chemical binding]; other site 1173027002583 Q-loop/lid; other site 1173027002584 ABC transporter signature motif; other site 1173027002585 Walker B; other site 1173027002586 D-loop; other site 1173027002587 H-loop/switch region; other site 1173027002588 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1173027002589 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1173027002590 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1173027002591 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1173027002592 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1173027002593 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1173027002594 RNase E interface [polypeptide binding]; other site 1173027002595 trimer interface [polypeptide binding]; other site 1173027002596 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1173027002597 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1173027002598 RNase E interface [polypeptide binding]; other site 1173027002599 trimer interface [polypeptide binding]; other site 1173027002600 active site 1173027002601 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1173027002602 putative nucleic acid binding region [nucleotide binding]; other site 1173027002603 G-X-X-G motif; other site 1173027002604 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1173027002605 RNA binding site [nucleotide binding]; other site 1173027002606 domain interface; other site 1173027002607 SNF2 Helicase protein; Region: DUF3670; pfam12419 1173027002608 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1173027002609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027002610 ATP binding site [chemical binding]; other site 1173027002611 putative Mg++ binding site [ion binding]; other site 1173027002612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027002613 nucleotide binding region [chemical binding]; other site 1173027002614 ATP-binding site [chemical binding]; other site 1173027002615 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1173027002616 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173027002617 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1173027002618 SWIM zinc finger; Region: SWIM; pfam04434 1173027002619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002621 TPR motif; other site 1173027002622 binding surface 1173027002623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027002624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027002625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002626 binding surface 1173027002627 TPR motif; other site 1173027002628 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173027002629 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1173027002630 putative active site [active] 1173027002631 Zn binding site [ion binding]; other site 1173027002632 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1173027002633 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1173027002634 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1173027002635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173027002636 Lysin motif; Region: LysM; smart00257 1173027002637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173027002638 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173027002639 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173027002640 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173027002641 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1173027002642 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173027002643 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173027002644 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1173027002645 dimer interface [polypeptide binding]; other site 1173027002646 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173027002647 catalytic triad [active] 1173027002648 peroxidatic and resolving cysteines [active] 1173027002649 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1173027002650 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1173027002651 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173027002652 active site 1173027002653 catalytic residues [active] 1173027002654 metal binding site [ion binding]; metal-binding site 1173027002655 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027002656 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027002657 phosphopeptide binding site; other site 1173027002658 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1173027002659 PAS fold; Region: PAS; pfam00989 1173027002660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002661 putative active site [active] 1173027002662 heme pocket [chemical binding]; other site 1173027002663 GAF domain; Region: GAF; pfam01590 1173027002664 GAF domain; Region: GAF_2; pfam13185 1173027002665 PAS domain S-box; Region: sensory_box; TIGR00229 1173027002666 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002667 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002668 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002669 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002671 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027002673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002674 dimer interface [polypeptide binding]; other site 1173027002675 phosphorylation site [posttranslational modification] 1173027002676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002677 ATP binding site [chemical binding]; other site 1173027002678 Mg2+ binding site [ion binding]; other site 1173027002679 G-X-G motif; other site 1173027002680 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027002681 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002682 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002683 TPR repeat; Region: TPR_11; pfam13414 1173027002684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002685 TPR motif; other site 1173027002686 binding surface 1173027002687 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1173027002688 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027002689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027002691 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1173027002692 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1173027002693 elongation factor G; Reviewed; Region: PRK12740 1173027002694 G1 box; other site 1173027002695 putative GEF interaction site [polypeptide binding]; other site 1173027002696 GTP/Mg2+ binding site [chemical binding]; other site 1173027002697 Switch I region; other site 1173027002698 G2 box; other site 1173027002699 G3 box; other site 1173027002700 Switch II region; other site 1173027002701 G4 box; other site 1173027002702 G5 box; other site 1173027002703 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173027002704 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173027002705 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173027002706 TPR repeat; Region: TPR_11; pfam13414 1173027002707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002708 binding surface 1173027002709 TPR motif; other site 1173027002710 TPR repeat; Region: TPR_11; pfam13414 1173027002711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002712 binding surface 1173027002713 TPR motif; other site 1173027002714 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027002715 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173027002716 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173027002717 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027002718 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027002719 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173027002720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027002721 active site 1173027002722 motif I; other site 1173027002723 phosphoglycolate phosphatase, TA0175-type; Region: Pglycolate_arch; TIGR01487 1173027002724 motif II; other site 1173027002725 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173027002726 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1173027002727 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1173027002728 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 1173027002729 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1173027002730 C-terminal peptidase (prc); Region: prc; TIGR00225 1173027002731 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173027002732 protein binding site [polypeptide binding]; other site 1173027002733 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173027002734 Catalytic dyad [active] 1173027002735 Protein of unknown function, DUF258; Region: DUF258; pfam03193 1173027002736 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027002737 structural tetrad; other site 1173027002738 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027002739 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027002740 structural tetrad; other site 1173027002741 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027002742 WD40 repeats; Region: WD40; smart00320 1173027002743 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1173027002744 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1173027002745 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1173027002746 cell division protein FtsZ; Validated; Region: PRK09330 1173027002747 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1173027002748 nucleotide binding site [chemical binding]; other site 1173027002749 SulA interaction site; other site 1173027002750 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1173027002751 dimer interface [polypeptide binding]; other site 1173027002752 substrate binding site [chemical binding]; other site 1173027002753 ATP binding site [chemical binding]; other site 1173027002754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1173027002755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027002756 dimerization interface [polypeptide binding]; other site 1173027002757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002758 putative active site [active] 1173027002759 heme pocket [chemical binding]; other site 1173027002760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002761 dimer interface [polypeptide binding]; other site 1173027002762 phosphorylation site [posttranslational modification] 1173027002763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002764 ATP binding site [chemical binding]; other site 1173027002765 Mg2+ binding site [ion binding]; other site 1173027002766 G-X-G motif; other site 1173027002767 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002769 active site 1173027002770 phosphorylation site [posttranslational modification] 1173027002771 intermolecular recognition site; other site 1173027002772 dimerization interface [polypeptide binding]; other site 1173027002773 TPR repeat; Region: TPR_11; pfam13414 1173027002774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027002775 binding surface 1173027002776 TPR motif; other site 1173027002777 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173027002778 4Fe-4S binding domain; Region: Fer4; pfam00037 1173027002779 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1173027002780 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 1173027002781 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027002782 catalytic residues [active] 1173027002783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002784 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027002786 non-specific DNA binding site [nucleotide binding]; other site 1173027002787 salt bridge; other site 1173027002788 sequence-specific DNA binding site [nucleotide binding]; other site 1173027002789 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173027002790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002791 Walker A/P-loop; other site 1173027002792 ATP binding site [chemical binding]; other site 1173027002793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027002794 ABC transporter signature motif; other site 1173027002795 Walker B; other site 1173027002796 D-loop; other site 1173027002797 H-loop/switch region; other site 1173027002798 hypothetical protein; Provisional; Region: PRK06850 1173027002799 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173027002800 Active Sites [active] 1173027002801 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1173027002802 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027002803 active site 1173027002804 DNA-sulfur modification-associated; Region: DndB; cl17621 1173027002805 DGQHR domain; Region: DGQHR; TIGR03187 1173027002806 DGQHR domain; Region: DGQHR; TIGR03187 1173027002807 DNA-sulfur modification-associated; Region: DndB; cl17621 1173027002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027002809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027002810 putative substrate translocation pore; other site 1173027002811 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002813 active site 1173027002814 phosphorylation site [posttranslational modification] 1173027002815 intermolecular recognition site; other site 1173027002816 dimerization interface [polypeptide binding]; other site 1173027002817 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1173027002818 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1173027002819 putative NADP binding site [chemical binding]; other site 1173027002820 putative substrate binding site [chemical binding]; other site 1173027002821 active site 1173027002822 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002823 putative active site [active] 1173027002824 AntA/AntB antirepressor; Region: AntA; cl01430 1173027002825 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173027002826 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1173027002827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002828 PAS domain; Region: PAS_9; pfam13426 1173027002829 putative active site [active] 1173027002830 heme pocket [chemical binding]; other site 1173027002831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002833 dimer interface [polypeptide binding]; other site 1173027002834 phosphorylation site [posttranslational modification] 1173027002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002836 ATP binding site [chemical binding]; other site 1173027002837 Mg2+ binding site [ion binding]; other site 1173027002838 G-X-G motif; other site 1173027002839 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173027002840 Subunit I/III interface [polypeptide binding]; other site 1173027002841 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173027002842 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1173027002843 D-pathway; other site 1173027002844 Subunit I/VIIc interface [polypeptide binding]; other site 1173027002845 Subunit I/IV interface [polypeptide binding]; other site 1173027002846 Subunit I/II interface [polypeptide binding]; other site 1173027002847 Low-spin heme (heme a) binding site [chemical binding]; other site 1173027002848 Subunit I/III interface [polypeptide binding]; other site 1173027002849 Subunit I/VIIa interface [polypeptide binding]; other site 1173027002850 Subunit I/VIa interface [polypeptide binding]; other site 1173027002851 Dimer interface; other site 1173027002852 Putative water exit pathway; other site 1173027002853 Binuclear center (heme a3/CuB) [ion binding]; other site 1173027002854 K-pathway; other site 1173027002855 Subunit I/Vb interface [polypeptide binding]; other site 1173027002856 Putative proton exit pathway; other site 1173027002857 Subunit I/VIb interface; other site 1173027002858 Subunit I/VIc interface [polypeptide binding]; other site 1173027002859 Electron transfer pathway; other site 1173027002860 Subunit I/VIIIb interface [polypeptide binding]; other site 1173027002861 Subunit I/VIIb interface [polypeptide binding]; other site 1173027002862 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1173027002863 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173027002864 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173027002865 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1173027002866 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1173027002867 4Fe-4S binding domain; Region: Fer4; pfam00037 1173027002868 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1173027002869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027002870 non-specific DNA binding site [nucleotide binding]; other site 1173027002871 salt bridge; other site 1173027002872 sequence-specific DNA binding site [nucleotide binding]; other site 1173027002873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1173027002874 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027002875 excinuclease ABC subunit B; Provisional; Region: PRK05298 1173027002876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027002877 ATP binding site [chemical binding]; other site 1173027002878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027002879 nucleotide binding region [chemical binding]; other site 1173027002880 ATP-binding site [chemical binding]; other site 1173027002881 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1173027002882 UvrB/uvrC motif; Region: UVR; pfam02151 1173027002883 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027002884 putative active site [active] 1173027002885 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027002886 G1 box; other site 1173027002887 GTP/Mg2+ binding site [chemical binding]; other site 1173027002888 G2 box; other site 1173027002889 PRC-barrel domain; Region: PRC; pfam05239 1173027002890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173027002891 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173027002892 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1173027002893 active site 1173027002894 Zn binding site [ion binding]; other site 1173027002895 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 1173027002896 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173027002897 active site 1173027002898 dimer interface [polypeptide binding]; other site 1173027002899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027002900 active site 1173027002901 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1173027002902 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1173027002903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027002904 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027002905 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173027002906 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173027002907 DNA binding residues [nucleotide binding] 1173027002908 dimer interface [polypeptide binding]; other site 1173027002909 metal binding site [ion binding]; metal-binding site 1173027002910 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173027002911 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1173027002912 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1173027002913 hexamer interface [polypeptide binding]; other site 1173027002914 ligand binding site [chemical binding]; other site 1173027002915 putative active site [active] 1173027002916 NAD(P) binding site [chemical binding]; other site 1173027002917 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027002918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027002919 active site 1173027002920 phosphorylation site [posttranslational modification] 1173027002921 intermolecular recognition site; other site 1173027002922 dimerization interface [polypeptide binding]; other site 1173027002923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027002924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027002925 metal binding site [ion binding]; metal-binding site 1173027002926 active site 1173027002927 I-site; other site 1173027002928 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173027002929 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173027002930 PAS domain S-box; Region: sensory_box; TIGR00229 1173027002931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002932 putative active site [active] 1173027002933 heme pocket [chemical binding]; other site 1173027002934 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027002935 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027002936 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027002937 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027002938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002939 putative active site [active] 1173027002940 heme pocket [chemical binding]; other site 1173027002941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027002942 putative active site [active] 1173027002943 heme pocket [chemical binding]; other site 1173027002944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027002945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027002946 dimer interface [polypeptide binding]; other site 1173027002947 phosphorylation site [posttranslational modification] 1173027002948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027002949 ATP binding site [chemical binding]; other site 1173027002950 Mg2+ binding site [ion binding]; other site 1173027002951 G-X-G motif; other site 1173027002952 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027002953 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173027002954 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173027002955 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1173027002956 DNA adenine methylase (dam); Region: dam; TIGR00571 1173027002957 Protein of unknown function (DUF751); Region: DUF751; pfam05421 1173027002958 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1173027002959 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173027002960 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173027002961 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1173027002962 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1173027002963 Ferritin-like domain; Region: Ferritin; pfam00210 1173027002964 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173027002965 dinuclear metal binding motif [ion binding]; other site 1173027002966 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173027002967 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173027002968 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173027002969 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173027002970 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1173027002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027002972 S-adenosylmethionine binding site [chemical binding]; other site 1173027002973 VanW like protein; Region: VanW; pfam04294 1173027002974 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173027002975 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173027002976 Walker A/P-loop; other site 1173027002977 ATP binding site [chemical binding]; other site 1173027002978 Q-loop/lid; other site 1173027002979 ABC transporter signature motif; other site 1173027002980 Walker B; other site 1173027002981 D-loop; other site 1173027002982 H-loop/switch region; other site 1173027002983 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1173027002984 cobalt transport protein CbiM; Validated; Region: PRK06265 1173027002985 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1173027002986 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173027002987 phosphodiesterase; Provisional; Region: PRK12704 1173027002988 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1173027002989 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1173027002990 YcaO-like family; Region: YcaO; pfam02624 1173027002991 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1173027002992 Amidohydrolase; Region: Amidohydro_2; pfam04909 1173027002993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027002994 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027002995 active site 1173027002996 ATP binding site [chemical binding]; other site 1173027002997 substrate binding site [chemical binding]; other site 1173027002998 activation loop (A-loop); other site 1173027002999 AAA ATPase domain; Region: AAA_16; pfam13191 1173027003000 Predicted ATPase [General function prediction only]; Region: COG3899 1173027003001 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027003002 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027003003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003004 dimer interface [polypeptide binding]; other site 1173027003005 phosphorylation site [posttranslational modification] 1173027003006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003007 ATP binding site [chemical binding]; other site 1173027003008 Mg2+ binding site [ion binding]; other site 1173027003009 G-X-G motif; other site 1173027003010 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003012 active site 1173027003013 phosphorylation site [posttranslational modification] 1173027003014 intermolecular recognition site; other site 1173027003015 dimerization interface [polypeptide binding]; other site 1173027003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003017 active site 1173027003018 phosphorylation site [posttranslational modification] 1173027003019 intermolecular recognition site; other site 1173027003020 dimerization interface [polypeptide binding]; other site 1173027003021 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027003022 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027003023 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003025 active site 1173027003026 phosphorylation site [posttranslational modification] 1173027003027 intermolecular recognition site; other site 1173027003028 dimerization interface [polypeptide binding]; other site 1173027003029 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027003030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003031 putative active site [active] 1173027003032 heme pocket [chemical binding]; other site 1173027003033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003034 dimer interface [polypeptide binding]; other site 1173027003035 phosphorylation site [posttranslational modification] 1173027003036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003037 ATP binding site [chemical binding]; other site 1173027003038 Mg2+ binding site [ion binding]; other site 1173027003039 G-X-G motif; other site 1173027003040 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003042 active site 1173027003043 phosphorylation site [posttranslational modification] 1173027003044 intermolecular recognition site; other site 1173027003045 dimerization interface [polypeptide binding]; other site 1173027003046 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027003047 cyclase homology domain; Region: CHD; cd07302 1173027003048 nucleotidyl binding site; other site 1173027003049 metal binding site [ion binding]; metal-binding site 1173027003050 dimer interface [polypeptide binding]; other site 1173027003051 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173027003052 metal binding site 2 [ion binding]; metal-binding site 1173027003053 putative DNA binding helix; other site 1173027003054 metal binding site 1 [ion binding]; metal-binding site 1173027003055 dimer interface [polypeptide binding]; other site 1173027003056 structural Zn2+ binding site [ion binding]; other site 1173027003057 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1173027003058 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173027003059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027003060 Walker A motif; other site 1173027003061 ATP binding site [chemical binding]; other site 1173027003062 Walker B motif; other site 1173027003063 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1173027003064 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173027003065 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173027003066 homodimer interface [polypeptide binding]; other site 1173027003067 active site 1173027003068 TDP-binding site; other site 1173027003069 acceptor substrate-binding pocket; other site 1173027003070 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1173027003071 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1173027003072 PBP superfamily domain; Region: PBP_like_2; cl17296 1173027003073 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173027003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027003075 dimer interface [polypeptide binding]; other site 1173027003076 conserved gate region; other site 1173027003077 putative PBP binding loops; other site 1173027003078 ABC-ATPase subunit interface; other site 1173027003079 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1173027003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027003081 dimer interface [polypeptide binding]; other site 1173027003082 conserved gate region; other site 1173027003083 putative PBP binding loops; other site 1173027003084 ABC-ATPase subunit interface; other site 1173027003085 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 1173027003086 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173027003087 Walker A/P-loop; other site 1173027003088 ATP binding site [chemical binding]; other site 1173027003089 Q-loop/lid; other site 1173027003090 ABC transporter signature motif; other site 1173027003091 Walker B; other site 1173027003092 D-loop; other site 1173027003093 H-loop/switch region; other site 1173027003094 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027003095 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173027003096 putative ADP-binding pocket [chemical binding]; other site 1173027003097 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 1173027003098 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027003099 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173027003100 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173027003101 trimer interface [polypeptide binding]; other site 1173027003102 active site 1173027003103 substrate binding site [chemical binding]; other site 1173027003104 CoA binding site [chemical binding]; other site 1173027003105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003106 TPR repeat; Region: TPR_11; pfam13414 1173027003107 binding surface 1173027003108 TPR motif; other site 1173027003109 TPR repeat; Region: TPR_11; pfam13414 1173027003110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003111 binding surface 1173027003112 TPR motif; other site 1173027003113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003114 binding surface 1173027003115 TPR motif; other site 1173027003116 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027003117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003118 binding surface 1173027003119 TPR motif; other site 1173027003120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003121 binding surface 1173027003122 TPR motif; other site 1173027003123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003124 binding surface 1173027003125 TPR repeat; Region: TPR_11; pfam13414 1173027003126 TPR motif; other site 1173027003127 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 1173027003128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027003129 active site 1173027003130 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027003131 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027003132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027003133 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1173027003134 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027003135 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027003136 MarR family; Region: MarR_2; cl17246 1173027003137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027003138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003139 binding surface 1173027003140 TPR motif; other site 1173027003141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027003142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027003143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027003144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003145 binding surface 1173027003146 TPR motif; other site 1173027003147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027003148 CHAT domain; Region: CHAT; pfam12770 1173027003149 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173027003150 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173027003151 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1173027003152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027003153 Walker A/P-loop; other site 1173027003154 ATP binding site [chemical binding]; other site 1173027003155 Q-loop/lid; other site 1173027003156 ABC transporter signature motif; other site 1173027003157 Walker B; other site 1173027003158 D-loop; other site 1173027003159 H-loop/switch region; other site 1173027003160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173027003161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027003162 Coenzyme A binding pocket [chemical binding]; other site 1173027003163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027003164 non-specific DNA binding site [nucleotide binding]; other site 1173027003165 salt bridge; other site 1173027003166 sequence-specific DNA binding site [nucleotide binding]; other site 1173027003167 Predicted membrane protein [Function unknown]; Region: COG2259 1173027003168 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173027003169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027003170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027003171 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1173027003172 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173027003173 TIGR04255 family protein; Region: sporadTIGR04255 1173027003174 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1173027003175 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173027003176 active site 1173027003177 Ca binding site [ion binding]; other site 1173027003178 catalytic site [active] 1173027003179 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 1173027003180 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1173027003181 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1173027003182 generic binding surface I; other site 1173027003183 generic binding surface II; other site 1173027003184 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027003185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027003186 active site 1173027003187 ATP binding site [chemical binding]; other site 1173027003188 substrate binding site [chemical binding]; other site 1173027003189 activation loop (A-loop); other site 1173027003190 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 1173027003191 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 1173027003192 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1173027003193 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1173027003194 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173027003195 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1173027003196 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173027003197 proposed catalytic triad [active] 1173027003198 active site nucleophile [active] 1173027003199 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1173027003200 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027003201 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027003202 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173027003203 S-layer homology domain; Region: SLH; pfam00395 1173027003204 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027003205 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1173027003206 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1173027003207 Peptidase M15; Region: Peptidase_M15_3; cl01194 1173027003208 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173027003209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027003210 active site 1173027003211 motif I; other site 1173027003212 motif II; other site 1173027003213 S-layer homology domain; Region: SLH; pfam00395 1173027003214 S-layer homology domain; Region: SLH; pfam00395 1173027003215 KWG Leptospira; Region: KWG; pfam07656 1173027003216 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027003217 KWG Leptospira; Region: KWG; pfam07656 1173027003218 aspartate kinase; Provisional; Region: PRK07431 1173027003219 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1173027003220 putative nucleotide binding site [chemical binding]; other site 1173027003221 putative catalytic residues [active] 1173027003222 putative Mg ion binding site [ion binding]; other site 1173027003223 putative aspartate binding site [chemical binding]; other site 1173027003224 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173027003225 putative allosteric regulatory site; other site 1173027003226 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173027003227 putative allosteric regulatory residue; other site 1173027003228 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173027003229 putative allosteric regulatory site; other site 1173027003230 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173027003231 putative allosteric regulatory residue; other site 1173027003232 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173027003233 putative catalytic site [active] 1173027003234 putative metal binding site [ion binding]; other site 1173027003235 putative phosphate binding site [ion binding]; other site 1173027003236 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173027003237 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173027003238 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173027003239 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1173027003240 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003242 active site 1173027003243 phosphorylation site [posttranslational modification] 1173027003244 intermolecular recognition site; other site 1173027003245 dimerization interface [polypeptide binding]; other site 1173027003246 PAS domain S-box; Region: sensory_box; TIGR00229 1173027003247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003248 putative active site [active] 1173027003249 heme pocket [chemical binding]; other site 1173027003250 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027003251 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027003252 PAS domain S-box; Region: sensory_box; TIGR00229 1173027003253 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027003254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003255 putative active site [active] 1173027003256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003257 dimer interface [polypeptide binding]; other site 1173027003258 phosphorylation site [posttranslational modification] 1173027003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003260 ATP binding site [chemical binding]; other site 1173027003261 G-X-G motif; other site 1173027003262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027003263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003264 active site 1173027003265 phosphorylation site [posttranslational modification] 1173027003266 intermolecular recognition site; other site 1173027003267 dimerization interface [polypeptide binding]; other site 1173027003268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027003269 DNA binding site [nucleotide binding] 1173027003270 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027003271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003272 active site 1173027003273 phosphorylation site [posttranslational modification] 1173027003274 intermolecular recognition site; other site 1173027003275 dimerization interface [polypeptide binding]; other site 1173027003276 hypothetical protein; Validated; Region: PRK00029 1173027003277 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1173027003278 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 1173027003279 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 1173027003280 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003282 active site 1173027003283 phosphorylation site [posttranslational modification] 1173027003284 intermolecular recognition site; other site 1173027003285 dimerization interface [polypeptide binding]; other site 1173027003286 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173027003287 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 1173027003288 active site 1173027003289 catalytic triad [active] 1173027003290 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1173027003291 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173027003292 active site 1173027003293 homodimer interface [polypeptide binding]; other site 1173027003294 catalytic site [active] 1173027003295 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173027003296 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173027003297 Fasciclin domain; Region: Fasciclin; pfam02469 1173027003298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027003299 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173027003300 Walker A/P-loop; other site 1173027003301 ATP binding site [chemical binding]; other site 1173027003302 Q-loop/lid; other site 1173027003303 ABC transporter signature motif; other site 1173027003304 Walker B; other site 1173027003305 D-loop; other site 1173027003306 H-loop/switch region; other site 1173027003307 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1173027003308 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1173027003309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1173027003310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1173027003311 catalytic residue [active] 1173027003312 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027003313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003314 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027003315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003317 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1173027003318 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1173027003319 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1173027003320 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1173027003321 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1173027003322 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173027003323 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173027003324 G1 box; other site 1173027003325 GTP/Mg2+ binding site [chemical binding]; other site 1173027003326 Switch I region; other site 1173027003327 G2 box; other site 1173027003328 Switch II region; other site 1173027003329 G3 box; other site 1173027003330 G4 box; other site 1173027003331 G5 box; other site 1173027003332 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173027003333 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1173027003334 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027003335 putative binding surface; other site 1173027003336 active site 1173027003337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027003338 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1173027003339 active site 1173027003340 photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049 1173027003341 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 1173027003342 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173027003343 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173027003344 active site 1173027003345 putative substrate binding region [chemical binding]; other site 1173027003346 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1173027003347 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1173027003348 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1173027003349 Cache domain; Region: Cache_1; pfam02743 1173027003350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027003351 dimerization interface [polypeptide binding]; other site 1173027003352 PAS fold; Region: PAS_3; pfam08447 1173027003353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003354 heme pocket [chemical binding]; other site 1173027003355 putative active site [active] 1173027003356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003357 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027003358 putative active site [active] 1173027003359 heme pocket [chemical binding]; other site 1173027003360 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027003361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003362 putative active site [active] 1173027003363 heme pocket [chemical binding]; other site 1173027003364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003365 PAS fold; Region: PAS_3; pfam08447 1173027003366 putative active site [active] 1173027003367 heme pocket [chemical binding]; other site 1173027003368 PAS domain S-box; Region: sensory_box; TIGR00229 1173027003369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003370 putative active site [active] 1173027003371 heme pocket [chemical binding]; other site 1173027003372 PAS domain S-box; Region: sensory_box; TIGR00229 1173027003373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003374 putative active site [active] 1173027003375 heme pocket [chemical binding]; other site 1173027003376 PAS domain S-box; Region: sensory_box; TIGR00229 1173027003377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003378 putative active site [active] 1173027003379 heme pocket [chemical binding]; other site 1173027003380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027003381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003382 dimer interface [polypeptide binding]; other site 1173027003383 phosphorylation site [posttranslational modification] 1173027003384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003385 ATP binding site [chemical binding]; other site 1173027003386 Mg2+ binding site [ion binding]; other site 1173027003387 G-X-G motif; other site 1173027003388 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027003389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003390 active site 1173027003391 phosphorylation site [posttranslational modification] 1173027003392 intermolecular recognition site; other site 1173027003393 dimerization interface [polypeptide binding]; other site 1173027003394 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173027003395 dinuclear metal binding motif [ion binding]; other site 1173027003396 glutamine synthetase, type I; Region: GlnA; TIGR00653 1173027003397 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1173027003398 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173027003399 allophycocyanin beta 18 subunit; Region: apcF; CHL00089 1173027003400 Protein kinase domain; Region: Pkinase; pfam00069 1173027003401 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027003402 active site 1173027003403 ATP binding site [chemical binding]; other site 1173027003404 substrate binding site [chemical binding]; other site 1173027003405 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027003406 substrate binding site [chemical binding]; other site 1173027003407 activation loop (A-loop); other site 1173027003408 activation loop (A-loop); other site 1173027003409 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1173027003410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027003411 AAA domain; Region: AAA_21; pfam13304 1173027003412 Walker A/P-loop; other site 1173027003413 ATP binding site [chemical binding]; other site 1173027003414 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027003415 putative active site [active] 1173027003416 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173027003417 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173027003418 Transmembrane secretion effector; Region: MFS_3; pfam05977 1173027003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027003420 putative substrate translocation pore; other site 1173027003421 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1173027003422 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1173027003423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173027003424 substrate binding pocket [chemical binding]; other site 1173027003425 membrane-bound complex binding site; other site 1173027003426 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1173027003427 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1173027003428 dimer interface [polypeptide binding]; other site 1173027003429 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1173027003430 active site 1173027003431 Fe binding site [ion binding]; other site 1173027003432 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003434 active site 1173027003435 phosphorylation site [posttranslational modification] 1173027003436 intermolecular recognition site; other site 1173027003437 dimerization interface [polypeptide binding]; other site 1173027003438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003439 PAS domain; Region: PAS_9; pfam13426 1173027003440 putative active site [active] 1173027003441 heme pocket [chemical binding]; other site 1173027003442 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027003443 cyclase homology domain; Region: CHD; cd07302 1173027003444 nucleotidyl binding site; other site 1173027003445 metal binding site [ion binding]; metal-binding site 1173027003446 dimer interface [polypeptide binding]; other site 1173027003447 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1173027003448 trimer interface [polypeptide binding]; other site 1173027003449 dimer interface [polypeptide binding]; other site 1173027003450 putative active site [active] 1173027003451 2TM domain; Region: 2TM; pfam13239 1173027003452 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 1173027003453 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1173027003454 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173027003455 PAS fold; Region: PAS; pfam00989 1173027003456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003457 putative active site [active] 1173027003458 heme pocket [chemical binding]; other site 1173027003459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003460 putative active site [active] 1173027003461 PAS fold; Region: PAS_3; pfam08447 1173027003462 heme pocket [chemical binding]; other site 1173027003463 PAS fold; Region: PAS_3; pfam08447 1173027003464 PAS fold; Region: PAS_4; pfam08448 1173027003465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003466 putative active site [active] 1173027003467 heme pocket [chemical binding]; other site 1173027003468 PAS fold; Region: PAS_3; pfam08447 1173027003469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003470 putative active site [active] 1173027003471 heme pocket [chemical binding]; other site 1173027003472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027003473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003474 dimer interface [polypeptide binding]; other site 1173027003475 phosphorylation site [posttranslational modification] 1173027003476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003477 ATP binding site [chemical binding]; other site 1173027003478 Mg2+ binding site [ion binding]; other site 1173027003479 G-X-G motif; other site 1173027003480 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1173027003481 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 1173027003482 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173027003483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027003484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027003485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027003486 Walker A/P-loop; other site 1173027003487 ATP binding site [chemical binding]; other site 1173027003488 Q-loop/lid; other site 1173027003489 ABC transporter signature motif; other site 1173027003490 Walker B; other site 1173027003491 D-loop; other site 1173027003492 H-loop/switch region; other site 1173027003493 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173027003494 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1173027003495 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027003496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027003497 phosphopeptide binding site; other site 1173027003498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027003500 S-adenosylmethionine binding site [chemical binding]; other site 1173027003501 primosome assembly protein PriA; Validated; Region: PRK05580 1173027003502 MarR family; Region: MarR_2; pfam12802 1173027003503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027003504 ATP binding site [chemical binding]; other site 1173027003505 putative Mg++ binding site [ion binding]; other site 1173027003506 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1173027003507 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1173027003508 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173027003509 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027003510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027003511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027003512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027003513 DNA binding residues [nucleotide binding] 1173027003514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027003515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027003516 Coenzyme A binding pocket [chemical binding]; other site 1173027003517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027003518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027003519 Coenzyme A binding pocket [chemical binding]; other site 1173027003520 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1173027003521 putative active site [active] 1173027003522 homotetrameric interface [polypeptide binding]; other site 1173027003523 metal binding site [ion binding]; metal-binding site 1173027003524 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1173027003525 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173027003526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003527 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027003528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003530 Membrane protein of unknown function; Region: DUF360; pfam04020 1173027003531 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1173027003532 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1173027003533 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1173027003534 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1173027003535 active site 1173027003536 SAM binding site [chemical binding]; other site 1173027003537 homodimer interface [polypeptide binding]; other site 1173027003538 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027003539 putative active site [active] 1173027003540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027003541 non-specific DNA binding site [nucleotide binding]; other site 1173027003542 salt bridge; other site 1173027003543 sequence-specific DNA binding site [nucleotide binding]; other site 1173027003544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027003545 non-specific DNA binding site [nucleotide binding]; other site 1173027003546 salt bridge; other site 1173027003547 sequence-specific DNA binding site [nucleotide binding]; other site 1173027003548 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027003549 putative active site [active] 1173027003550 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173027003551 PLD-like domain; Region: PLDc_2; pfam13091 1173027003552 putative active site [active] 1173027003553 catalytic site [active] 1173027003554 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1173027003555 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173027003556 active site 1173027003557 interdomain interaction site; other site 1173027003558 putative metal-binding site [ion binding]; other site 1173027003559 nucleotide binding site [chemical binding]; other site 1173027003560 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173027003561 domain I; other site 1173027003562 phosphate binding site [ion binding]; other site 1173027003563 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173027003564 domain II; other site 1173027003565 domain III; other site 1173027003566 nucleotide binding site [chemical binding]; other site 1173027003567 DNA binding groove [nucleotide binding] 1173027003568 catalytic site [active] 1173027003569 domain IV; other site 1173027003570 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173027003571 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173027003572 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173027003573 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173027003574 Protein kinase domain; Region: Pkinase; pfam00069 1173027003575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027003576 active site 1173027003577 ATP binding site [chemical binding]; other site 1173027003578 substrate binding site [chemical binding]; other site 1173027003579 activation loop (A-loop); other site 1173027003580 activation loop (A-loop); other site 1173027003581 AAA ATPase domain; Region: AAA_16; pfam13191 1173027003582 Predicted ATPase [General function prediction only]; Region: COG3899 1173027003583 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027003584 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027003585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027003586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003587 dimer interface [polypeptide binding]; other site 1173027003588 phosphorylation site [posttranslational modification] 1173027003589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003590 ATP binding site [chemical binding]; other site 1173027003591 Mg2+ binding site [ion binding]; other site 1173027003592 G-X-G motif; other site 1173027003593 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003595 active site 1173027003596 phosphorylation site [posttranslational modification] 1173027003597 intermolecular recognition site; other site 1173027003598 dimerization interface [polypeptide binding]; other site 1173027003599 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003601 active site 1173027003602 phosphorylation site [posttranslational modification] 1173027003603 intermolecular recognition site; other site 1173027003604 dimerization interface [polypeptide binding]; other site 1173027003605 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027003606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003607 putative active site [active] 1173027003608 heme pocket [chemical binding]; other site 1173027003609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003610 histidine kinase; Provisional; Region: PRK13557 1173027003611 putative active site [active] 1173027003612 heme pocket [chemical binding]; other site 1173027003613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003614 dimer interface [polypeptide binding]; other site 1173027003615 phosphorylation site [posttranslational modification] 1173027003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003617 ATP binding site [chemical binding]; other site 1173027003618 Mg2+ binding site [ion binding]; other site 1173027003619 G-X-G motif; other site 1173027003620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003621 active site 1173027003622 phosphorylation site [posttranslational modification] 1173027003623 intermolecular recognition site; other site 1173027003624 dimerization interface [polypeptide binding]; other site 1173027003625 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 1173027003626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027003627 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1173027003628 putative active site [active] 1173027003629 catalytic site [active] 1173027003630 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1173027003631 putative active site [active] 1173027003632 catalytic site [active] 1173027003633 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173027003634 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027003635 putative active site [active] 1173027003636 putative metal binding site [ion binding]; other site 1173027003637 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027003638 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027003639 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027003640 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173027003641 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027003642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027003643 Rhomboid family; Region: Rhomboid; pfam01694 1173027003644 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1173027003645 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027003646 putative active site [active] 1173027003647 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 1173027003648 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 1173027003649 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 1173027003650 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173027003651 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173027003652 active site 1173027003653 catalytic residues [active] 1173027003654 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1173027003655 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1173027003656 substrate binding site [chemical binding]; other site 1173027003657 hexamer interface [polypeptide binding]; other site 1173027003658 metal binding site [ion binding]; metal-binding site 1173027003659 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1173027003660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027003661 S-adenosylmethionine binding site [chemical binding]; other site 1173027003662 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027003663 GAF domain; Region: GAF_2; pfam13185 1173027003664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173027003665 PAS fold; Region: PAS_3; pfam08447 1173027003666 putative active site [active] 1173027003667 heme pocket [chemical binding]; other site 1173027003668 RNA ligase; Region: RNA_ligase; pfam09414 1173027003669 TPR repeat; Region: TPR_11; pfam13414 1173027003670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027003671 binding surface 1173027003672 TPR motif; other site 1173027003673 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027003674 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 1173027003675 serpin-like protein; Provisional; Region: PHA02660 1173027003676 reactive center loop; other site 1173027003677 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1173027003678 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1173027003679 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1173027003680 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1173027003681 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173027003682 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173027003683 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1173027003684 Lumazine binding domain; Region: Lum_binding; pfam00677 1173027003685 Lumazine binding domain; Region: Lum_binding; pfam00677 1173027003686 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1173027003687 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173027003688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027003689 active site 1173027003690 catalytic tetrad [active] 1173027003691 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1173027003692 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1173027003693 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1173027003694 ligand binding site [chemical binding]; other site 1173027003695 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 1173027003696 Rab subfamily motif 1 (RabSF1); other site 1173027003697 G1 box; other site 1173027003698 GTP/Mg2+ binding site [chemical binding]; other site 1173027003699 Rab subfamily motif 2 (RabSF2); other site 1173027003700 Switch I region; other site 1173027003701 G2 box; other site 1173027003702 effector interaction site; other site 1173027003703 GDI interaction site; other site 1173027003704 Rab family motif 1 (RabF1); other site 1173027003705 GEF interaction site [polypeptide binding]; other site 1173027003706 Rab family motif 2 (RabF2); other site 1173027003707 G3 box; other site 1173027003708 Switch II region; other site 1173027003709 Rab family motif 3 (RabF3); other site 1173027003710 Rab family motif 4 (RabF4); other site 1173027003711 Rab family motif 5 (RabF5); other site 1173027003712 Rab subfamily motif 3 (RabSF3); other site 1173027003713 G4 box; other site 1173027003714 G5 box; other site 1173027003715 Rab subfamily motif 4 (RabSF4); other site 1173027003716 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027003717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027003718 putative active site [active] 1173027003719 heme pocket [chemical binding]; other site 1173027003720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027003721 dimer interface [polypeptide binding]; other site 1173027003722 phosphorylation site [posttranslational modification] 1173027003723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003724 ATP binding site [chemical binding]; other site 1173027003725 Mg2+ binding site [ion binding]; other site 1173027003726 G-X-G motif; other site 1173027003727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027003728 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027003729 NAD(P) binding site [chemical binding]; other site 1173027003730 active site 1173027003731 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1173027003732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003733 ATP binding site [chemical binding]; other site 1173027003734 Mg2+ binding site [ion binding]; other site 1173027003735 G-X-G motif; other site 1173027003736 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1173027003737 ATP binding site [chemical binding]; other site 1173027003738 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1173027003739 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173027003740 AMIN domain; Region: AMIN; pfam11741 1173027003741 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027003742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027003743 active site 1173027003744 metal binding site [ion binding]; metal-binding site 1173027003745 Domain of unknown function (DUF389); Region: DUF389; cl00781 1173027003746 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173027003747 putative catalytic site [active] 1173027003748 putative metal binding site [ion binding]; other site 1173027003749 putative phosphate binding site [ion binding]; other site 1173027003750 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173027003751 Ion transport protein; Region: Ion_trans; pfam00520 1173027003752 Ion channel; Region: Ion_trans_2; pfam07885 1173027003753 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027003754 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173027003755 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173027003756 homodimer interface [polypeptide binding]; other site 1173027003757 Walker A motif; other site 1173027003758 ATP binding site [chemical binding]; other site 1173027003759 hydroxycobalamin binding site [chemical binding]; other site 1173027003760 Walker B motif; other site 1173027003761 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1173027003762 putative ADP-ribose binding site [chemical binding]; other site 1173027003763 putative active site [active] 1173027003764 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173027003765 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173027003766 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1173027003767 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1173027003768 nucleotide binding pocket [chemical binding]; other site 1173027003769 K-X-D-G motif; other site 1173027003770 catalytic site [active] 1173027003771 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1173027003772 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1173027003773 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1173027003774 Dimer interface [polypeptide binding]; other site 1173027003775 BRCT sequence motif; other site 1173027003776 Caspase domain; Region: Peptidase_C14; pfam00656 1173027003777 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027003778 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173027003779 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173027003780 active site residue [active] 1173027003781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027003782 active site residue [active] 1173027003783 tellurite resistance protein terB; Region: terB; cd07176 1173027003784 putative metal binding site [ion binding]; other site 1173027003785 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173027003786 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173027003787 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003789 active site 1173027003790 phosphorylation site [posttranslational modification] 1173027003791 intermolecular recognition site; other site 1173027003792 dimerization interface [polypeptide binding]; other site 1173027003793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003794 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027003795 active site 1173027003796 phosphorylation site [posttranslational modification] 1173027003797 intermolecular recognition site; other site 1173027003798 dimerization interface [polypeptide binding]; other site 1173027003799 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173027003800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027003801 dimerization interface [polypeptide binding]; other site 1173027003802 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027003803 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027003804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173027003805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027003806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027003807 dimer interface [polypeptide binding]; other site 1173027003808 putative CheW interface [polypeptide binding]; other site 1173027003809 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027003810 putative binding surface; other site 1173027003811 active site 1173027003812 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027003813 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027003815 ATP binding site [chemical binding]; other site 1173027003816 Mg2+ binding site [ion binding]; other site 1173027003817 G-X-G motif; other site 1173027003818 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027003819 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027003820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027003821 active site 1173027003822 phosphorylation site [posttranslational modification] 1173027003823 intermolecular recognition site; other site 1173027003824 dimerization interface [polypeptide binding]; other site 1173027003825 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1173027003826 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173027003827 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1173027003828 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1173027003829 putative active site [active] 1173027003830 putative dimer interface [polypeptide binding]; other site 1173027003831 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173027003832 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003833 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027003834 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027003835 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027003836 putative active site [active] 1173027003837 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1173027003838 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173027003839 MG2 domain; Region: A2M_N; pfam01835 1173027003840 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1173027003841 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1173027003842 surface patch; other site 1173027003843 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1173027003844 SelR domain; Region: SelR; pfam01641 1173027003845 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1173027003846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027003847 dimer interface [polypeptide binding]; other site 1173027003848 conserved gate region; other site 1173027003849 putative PBP binding loops; other site 1173027003850 ABC-ATPase subunit interface; other site 1173027003851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027003852 Walker A/P-loop; other site 1173027003853 ATP binding site [chemical binding]; other site 1173027003854 ABC transporter; Region: ABC_tran; pfam00005 1173027003855 Q-loop/lid; other site 1173027003856 ABC transporter signature motif; other site 1173027003857 Walker B; other site 1173027003858 D-loop; other site 1173027003859 H-loop/switch region; other site 1173027003860 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1173027003861 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173027003862 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1173027003863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027003864 S-adenosylmethionine binding site [chemical binding]; other site 1173027003865 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1173027003866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027003867 G1 box; other site 1173027003868 GTP/Mg2+ binding site [chemical binding]; other site 1173027003869 G2 box; other site 1173027003870 Switch I region; other site 1173027003871 G3 box; other site 1173027003872 Switch II region; other site 1173027003873 G4 box; other site 1173027003874 G5 box; other site 1173027003875 FeoA domain; Region: FeoA; pfam04023 1173027003876 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027003877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027003878 catalytic loop [active] 1173027003879 iron binding site [ion binding]; other site 1173027003880 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173027003881 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1173027003882 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1173027003883 ATP binding site [chemical binding]; other site 1173027003884 substrate interface [chemical binding]; other site 1173027003885 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 1173027003886 Rop-like; Region: Rop-like; pfam05082 1173027003887 Protein of unknown function, DUF269; Region: DUF269; pfam03270 1173027003888 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1173027003889 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1173027003890 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1173027003891 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1173027003892 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1173027003893 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173027003894 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1173027003895 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1173027003896 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1173027003897 MoFe protein beta/alpha subunit interactions; other site 1173027003898 Beta subunit P cluster binding residues; other site 1173027003899 MoFe protein beta subunit/Fe protein contacts; other site 1173027003900 MoFe protein dimer/ dimer interactions; other site 1173027003901 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1173027003902 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1173027003903 MoFe protein alpha/beta subunit interactions; other site 1173027003904 Alpha subunit P cluster binding residues; other site 1173027003905 FeMoco binding residues [chemical binding]; other site 1173027003906 MoFe protein alpha subunit/Fe protein contacts; other site 1173027003907 MoFe protein dimer/ dimer interactions; other site 1173027003908 nitrogenase reductase; Reviewed; Region: PRK13236 1173027003909 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1173027003910 Nucleotide-binding sites [chemical binding]; other site 1173027003911 Walker A motif; other site 1173027003912 Switch I region of nucleotide binding site; other site 1173027003913 Fe4S4 binding sites [ion binding]; other site 1173027003914 Switch II region of nucleotide binding site; other site 1173027003915 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1173027003916 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1173027003917 trimerization site [polypeptide binding]; other site 1173027003918 active site 1173027003919 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173027003920 NifU-like domain; Region: NifU; pfam01106 1173027003921 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173027003922 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173027003923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027003924 catalytic residue [active] 1173027003925 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1173027003926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027003927 FeS/SAM binding site; other site 1173027003928 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1173027003929 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173027003930 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1173027003931 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173027003932 trimer interface [polypeptide binding]; other site 1173027003933 active site 1173027003934 substrate binding site [chemical binding]; other site 1173027003935 CoA binding site [chemical binding]; other site 1173027003936 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173027003937 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173027003938 dimerization interface [polypeptide binding]; other site 1173027003939 DPS ferroxidase diiron center [ion binding]; other site 1173027003940 ion pore; other site 1173027003941 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173027003942 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1173027003943 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1173027003944 active site 1173027003945 catalytic residues [active] 1173027003946 metal binding site [ion binding]; metal-binding site 1173027003947 NifZ domain; Region: NifZ; pfam04319 1173027003948 NifT/FixU protein; Region: NifT; pfam06988 1173027003949 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027003950 dimer interface [polypeptide binding]; other site 1173027003951 [2Fe-2S] cluster binding site [ion binding]; other site 1173027003952 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027003953 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003954 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003956 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027003957 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003959 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027003960 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1173027003961 Predicted permease [General function prediction only]; Region: COG3329 1173027003962 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173027003963 FAD binding domain; Region: FAD_binding_4; pfam01565 1173027003964 cytosine deaminase-like protein; Validated; Region: PRK07583 1173027003965 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1173027003966 active site 1173027003967 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173027003968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027003969 dimer interface [polypeptide binding]; other site 1173027003970 conserved gate region; other site 1173027003971 putative PBP binding loops; other site 1173027003972 ABC-ATPase subunit interface; other site 1173027003973 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027003974 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027003975 active site 1173027003976 ATP binding site [chemical binding]; other site 1173027003977 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027003978 substrate binding site [chemical binding]; other site 1173027003979 activation loop (A-loop); other site 1173027003980 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173027003981 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1173027003982 active site 1173027003983 trimer interface [polypeptide binding]; other site 1173027003984 allosteric site; other site 1173027003985 active site lid [active] 1173027003986 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1173027003987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027003988 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1173027003989 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027003990 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027003991 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027003992 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027003993 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027003994 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027003995 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 1173027003996 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173027003997 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173027003998 active site 1173027003999 catalytic site [active] 1173027004000 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1173027004001 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 1173027004002 starch-binding site 2 [chemical binding]; other site 1173027004003 starch-binding site 1 [chemical binding]; other site 1173027004004 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173027004005 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027004006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004007 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004009 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173027004010 NADPH bind site [chemical binding]; other site 1173027004011 putative FMN binding site [chemical binding]; other site 1173027004012 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173027004013 putative FMN binding site [chemical binding]; other site 1173027004014 NADPH bind site [chemical binding]; other site 1173027004015 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004017 active site 1173027004018 phosphorylation site [posttranslational modification] 1173027004019 intermolecular recognition site; other site 1173027004020 dimerization interface [polypeptide binding]; other site 1173027004021 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1173027004022 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 1173027004023 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1173027004024 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1173027004025 putative active site [active] 1173027004026 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173027004027 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173027004028 active site 1173027004029 putative substrate binding region [chemical binding]; other site 1173027004030 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1173027004031 Pyruvate formate lyase 1; Region: PFL1; cd01678 1173027004032 coenzyme A binding site [chemical binding]; other site 1173027004033 active site 1173027004034 catalytic residues [active] 1173027004035 glycine loop; other site 1173027004036 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1173027004037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027004038 FeS/SAM binding site; other site 1173027004039 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1173027004040 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1173027004041 putative catalytic cysteine [active] 1173027004042 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1173027004043 putative active site [active] 1173027004044 metal binding site [ion binding]; metal-binding site 1173027004045 V4R domain; Region: V4R; cl15268 1173027004046 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1173027004047 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1173027004048 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1173027004049 transmembrane helices; other site 1173027004050 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173027004051 metal binding site 2 [ion binding]; metal-binding site 1173027004052 putative DNA binding helix; other site 1173027004053 metal binding site 1 [ion binding]; metal-binding site 1173027004054 dimer interface [polypeptide binding]; other site 1173027004055 structural Zn2+ binding site [ion binding]; other site 1173027004056 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1173027004057 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1173027004058 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1173027004059 putative active site [active] 1173027004060 catalytic triad [active] 1173027004061 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004062 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027004063 structural tetrad; other site 1173027004064 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173027004065 Dynamin family; Region: Dynamin_N; pfam00350 1173027004066 G1 box; other site 1173027004067 GTP/Mg2+ binding site [chemical binding]; other site 1173027004068 G2 box; other site 1173027004069 Switch I region; other site 1173027004070 G3 box; other site 1173027004071 Switch II region; other site 1173027004072 G4 box; other site 1173027004073 G5 box; other site 1173027004074 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173027004075 Dynamin family; Region: Dynamin_N; pfam00350 1173027004076 G1 box; other site 1173027004077 GTP/Mg2+ binding site [chemical binding]; other site 1173027004078 G2 box; other site 1173027004079 Switch I region; other site 1173027004080 G3 box; other site 1173027004081 Switch II region; other site 1173027004082 G4 box; other site 1173027004083 G5 box; other site 1173027004084 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027004085 Dynamin family; Region: Dynamin_N; pfam00350 1173027004086 G1 box; other site 1173027004087 GTP/Mg2+ binding site [chemical binding]; other site 1173027004088 G2 box; other site 1173027004089 Switch I region; other site 1173027004090 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173027004091 G3 box; other site 1173027004092 Switch II region; other site 1173027004093 GTP/Mg2+ binding site [chemical binding]; other site 1173027004094 G4 box; other site 1173027004095 G5 box; other site 1173027004096 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027004097 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027004098 phosphopeptide binding site; other site 1173027004099 Double zinc ribbon; Region: DZR; pfam12773 1173027004100 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173027004101 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027004102 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027004103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027004104 phosphopeptide binding site; other site 1173027004105 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173027004106 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1173027004107 putative active site [active] 1173027004108 Chaperone for protein-folding within the ER, fungal; Region: Rot1; pfam10681 1173027004109 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1173027004110 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 1173027004111 putative RNA binding site [nucleotide binding]; other site 1173027004112 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1173027004113 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1173027004114 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173027004115 P loop; other site 1173027004116 GTP binding site [chemical binding]; other site 1173027004117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027004118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004119 active site 1173027004120 phosphorylation site [posttranslational modification] 1173027004121 intermolecular recognition site; other site 1173027004122 dimerization interface [polypeptide binding]; other site 1173027004123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027004124 DNA binding residues [nucleotide binding] 1173027004125 dimerization interface [polypeptide binding]; other site 1173027004126 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004127 putative active site [active] 1173027004128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004129 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1173027004130 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173027004131 hydrophobic ligand binding site; other site 1173027004132 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1173027004133 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1173027004134 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1173027004135 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1173027004136 RuvA N terminal domain; Region: RuvA_N; pfam01330 1173027004137 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1173027004138 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 1173027004139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027004140 active site 1173027004141 motif I; other site 1173027004142 motif II; other site 1173027004143 TIR domain; Region: TIR_2; pfam13676 1173027004144 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004145 structural tetrad; other site 1173027004146 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027004147 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004148 structural tetrad; other site 1173027004149 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 1173027004150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027004151 TPR motif; other site 1173027004152 binding surface 1173027004153 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1173027004154 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173027004155 C-terminal peptidase (prc); Region: prc; TIGR00225 1173027004156 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173027004157 protein binding site [polypeptide binding]; other site 1173027004158 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1173027004159 Domain interface; other site 1173027004160 Peptide binding site; other site 1173027004161 Active site tetrad [active] 1173027004162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004164 active site 1173027004165 ATP binding site [chemical binding]; other site 1173027004166 substrate binding site [chemical binding]; other site 1173027004167 activation loop (A-loop); other site 1173027004168 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 1173027004169 GIY-YIG motif/motif A; other site 1173027004170 S-layer homology domain; Region: SLH; pfam00395 1173027004171 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027004172 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027004173 S-layer homology domain; Region: SLH; pfam00395 1173027004174 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027004175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027004176 dimerization interface [polypeptide binding]; other site 1173027004177 putative DNA binding site [nucleotide binding]; other site 1173027004178 putative Zn2+ binding site [ion binding]; other site 1173027004179 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1173027004180 Repair protein; Region: Repair_PSII; pfam04536 1173027004181 precorrin-8X methylmutase; Validated; Region: PRK05953 1173027004182 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173027004183 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 1173027004184 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173027004185 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1173027004186 glycogen binding site [chemical binding]; other site 1173027004187 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1173027004188 active site 1173027004189 catalytic site [active] 1173027004190 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173027004191 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004192 putative active site [active] 1173027004193 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173027004194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027004195 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1173027004196 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1173027004197 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1173027004198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027004199 Mg2+ binding site [ion binding]; other site 1173027004200 G-X-G motif; other site 1173027004201 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1173027004202 anchoring element; other site 1173027004203 dimer interface [polypeptide binding]; other site 1173027004204 ATP binding site [chemical binding]; other site 1173027004205 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1173027004206 active site 1173027004207 putative metal-binding site [ion binding]; other site 1173027004208 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1173027004209 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1173027004210 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1173027004211 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 1173027004212 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173027004213 heme binding pocket [chemical binding]; other site 1173027004214 heme ligand [chemical binding]; other site 1173027004215 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173027004216 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173027004217 core dimer interface [polypeptide binding]; other site 1173027004218 peripheral dimer interface [polypeptide binding]; other site 1173027004219 L10 interface [polypeptide binding]; other site 1173027004220 L11 interface [polypeptide binding]; other site 1173027004221 putative EF-Tu interaction site [polypeptide binding]; other site 1173027004222 putative EF-G interaction site [polypeptide binding]; other site 1173027004223 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1173027004224 23S rRNA interface [nucleotide binding]; other site 1173027004225 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1173027004226 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1173027004227 mRNA/rRNA interface [nucleotide binding]; other site 1173027004228 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1173027004229 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1173027004230 23S rRNA interface [nucleotide binding]; other site 1173027004231 L7/L12 interface [polypeptide binding]; other site 1173027004232 putative thiostrepton binding site; other site 1173027004233 L25 interface [polypeptide binding]; other site 1173027004234 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1173027004235 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1173027004236 putative homodimer interface [polypeptide binding]; other site 1173027004237 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1173027004238 heterodimer interface [polypeptide binding]; other site 1173027004239 homodimer interface [polypeptide binding]; other site 1173027004240 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1173027004241 ribosomal protein L19; Region: rpl19; CHL00084 1173027004242 S-layer homology domain; Region: SLH; pfam00395 1173027004243 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027004244 S-layer homology domain; Region: SLH; pfam00395 1173027004245 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027004246 S-layer homology domain; Region: SLH; pfam00395 1173027004247 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027004248 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1173027004249 PhoU domain; Region: PhoU; pfam01895 1173027004250 PhoU domain; Region: PhoU; pfam01895 1173027004251 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027004252 PAS domain; Region: PAS; smart00091 1173027004253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027004254 dimer interface [polypeptide binding]; other site 1173027004255 phosphorylation site [posttranslational modification] 1173027004256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027004257 ATP binding site [chemical binding]; other site 1173027004258 Mg2+ binding site [ion binding]; other site 1173027004259 G-X-G motif; other site 1173027004260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004262 active site 1173027004263 phosphorylation site [posttranslational modification] 1173027004264 intermolecular recognition site; other site 1173027004265 dimerization interface [polypeptide binding]; other site 1173027004266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027004267 DNA binding site [nucleotide binding] 1173027004268 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1173027004269 DNA repair protein RadA; Provisional; Region: PRK11823 1173027004270 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1173027004271 Walker A motif/ATP binding site; other site 1173027004272 ATP binding site [chemical binding]; other site 1173027004273 Walker B motif; other site 1173027004274 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173027004275 Ycf27; Reviewed; Region: orf27; CHL00148 1173027004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004277 active site 1173027004278 phosphorylation site [posttranslational modification] 1173027004279 intermolecular recognition site; other site 1173027004280 dimerization interface [polypeptide binding]; other site 1173027004281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027004282 DNA binding site [nucleotide binding] 1173027004283 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 1173027004284 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173027004285 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1173027004286 putative di-iron ligands [ion binding]; other site 1173027004287 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1173027004288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027004289 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004290 putative active site [active] 1173027004291 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173027004292 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173027004293 active site 1173027004294 dimer interface [polypeptide binding]; other site 1173027004295 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173027004296 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173027004297 active site 1173027004298 FMN binding site [chemical binding]; other site 1173027004299 substrate binding site [chemical binding]; other site 1173027004300 3Fe-4S cluster binding site [ion binding]; other site 1173027004301 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173027004302 domain interface; other site 1173027004303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027004304 non-specific DNA binding site [nucleotide binding]; other site 1173027004305 salt bridge; other site 1173027004306 sequence-specific DNA binding site [nucleotide binding]; other site 1173027004307 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1173027004308 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1173027004309 protease 4; Provisional; Region: PRK10949 1173027004310 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1173027004311 tandem repeat interface [polypeptide binding]; other site 1173027004312 oligomer interface [polypeptide binding]; other site 1173027004313 active site residues [active] 1173027004314 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173027004315 tandem repeat interface [polypeptide binding]; other site 1173027004316 oligomer interface [polypeptide binding]; other site 1173027004317 active site residues [active] 1173027004318 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1173027004319 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1173027004320 homotetramer interface [polypeptide binding]; other site 1173027004321 FMN binding site [chemical binding]; other site 1173027004322 homodimer contacts [polypeptide binding]; other site 1173027004323 putative active site [active] 1173027004324 putative substrate binding site [chemical binding]; other site 1173027004325 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1173027004326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027004327 active site 1173027004328 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027004329 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027004330 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027004331 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027004332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027004333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027004334 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1173027004335 Predicted transcriptional regulator [Transcription]; Region: COG1959 1173027004336 Transcriptional regulator; Region: Rrf2; cl17282 1173027004337 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173027004338 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173027004339 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173027004340 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173027004341 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173027004342 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027004343 TrkA-N domain; Region: TrkA_N; pfam02254 1173027004344 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1173027004345 active site 1173027004346 SAM binding site [chemical binding]; other site 1173027004347 homodimer interface [polypeptide binding]; other site 1173027004348 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1173027004349 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1173027004350 trimer interface [polypeptide binding]; other site 1173027004351 putative Zn binding site [ion binding]; other site 1173027004352 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 1173027004353 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004355 active site 1173027004356 phosphorylation site [posttranslational modification] 1173027004357 intermolecular recognition site; other site 1173027004358 dimerization interface [polypeptide binding]; other site 1173027004359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027004360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027004361 dimerization interface [polypeptide binding]; other site 1173027004362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027004363 dimer interface [polypeptide binding]; other site 1173027004364 phosphorylation site [posttranslational modification] 1173027004365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027004366 ATP binding site [chemical binding]; other site 1173027004367 Mg2+ binding site [ion binding]; other site 1173027004368 G-X-G motif; other site 1173027004369 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173027004370 Fasciclin domain; Region: Fasciclin; pfam02469 1173027004371 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173027004372 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1173027004373 active site 1173027004374 catalytic site [active] 1173027004375 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1173027004376 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173027004377 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173027004378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004380 active site 1173027004381 substrate binding site [chemical binding]; other site 1173027004382 ATP binding site [chemical binding]; other site 1173027004383 activation loop (A-loop); other site 1173027004384 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027004385 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004386 structural tetrad; other site 1173027004387 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173027004388 protein I interface; other site 1173027004389 D2 interface; other site 1173027004390 protein T interface; other site 1173027004391 chlorophyll binding site; other site 1173027004392 beta carotene binding site; other site 1173027004393 pheophytin binding site; other site 1173027004394 manganese-stabilizing polypeptide interface; other site 1173027004395 CP43 interface; other site 1173027004396 protein L interface; other site 1173027004397 oxygen evolving complex binding site; other site 1173027004398 bromide binding site; other site 1173027004399 quinone binding site; other site 1173027004400 Fe binding site [ion binding]; other site 1173027004401 core light harvesting interface; other site 1173027004402 cytochrome b559 alpha subunit interface; other site 1173027004403 cytochrome c-550 interface; other site 1173027004404 protein J interface; other site 1173027004405 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1173027004406 nucleotide binding site/active site [active] 1173027004407 HIT family signature motif; other site 1173027004408 catalytic residue [active] 1173027004409 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1173027004410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173027004411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027004412 Walker A motif; other site 1173027004413 ATP binding site [chemical binding]; other site 1173027004414 Walker B motif; other site 1173027004415 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1173027004416 adenylosuccinate lyase; Provisional; Region: PRK07380 1173027004417 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1173027004418 tetramer interface [polypeptide binding]; other site 1173027004419 active site 1173027004420 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1173027004421 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173027004422 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173027004423 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027004424 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173027004425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004426 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1173027004427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004428 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004429 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004430 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027004431 HSP70 interaction site [polypeptide binding]; other site 1173027004432 recombination protein RecR; Reviewed; Region: recR; PRK00076 1173027004433 RecR protein; Region: RecR; pfam02132 1173027004434 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1173027004435 putative active site [active] 1173027004436 putative metal-binding site [ion binding]; other site 1173027004437 tetramer interface [polypeptide binding]; other site 1173027004438 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004440 active site 1173027004441 phosphorylation site [posttranslational modification] 1173027004442 intermolecular recognition site; other site 1173027004443 dimerization interface [polypeptide binding]; other site 1173027004444 lipoyl synthase; Provisional; Region: PRK12928 1173027004445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027004446 FeS/SAM binding site; other site 1173027004447 PsaX family; Region: PsaX; pfam08078 1173027004448 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173027004449 putative hydrophobic ligand binding site [chemical binding]; other site 1173027004450 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 1173027004451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027004452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027004453 non-specific DNA binding site [nucleotide binding]; other site 1173027004454 salt bridge; other site 1173027004455 sequence-specific DNA binding site [nucleotide binding]; other site 1173027004456 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173027004457 putative active site [active] 1173027004458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027004461 binding surface 1173027004462 TPR motif; other site 1173027004463 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027004465 binding surface 1173027004466 TPR motif; other site 1173027004467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004468 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027004471 binding surface 1173027004472 TPR motif; other site 1173027004473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027004475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027004476 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173027004477 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1173027004478 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1173027004479 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1173027004480 NAD binding site [chemical binding]; other site 1173027004481 dimer interface [polypeptide binding]; other site 1173027004482 substrate binding site [chemical binding]; other site 1173027004483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027004484 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027004485 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027004486 Calx-beta domain; Region: Calx-beta; cl02522 1173027004487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027004488 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1173027004489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1173027004490 Right handed beta helix region; Region: Beta_helix; pfam13229 1173027004491 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1173027004492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1173027004493 ligand binding site [chemical binding]; other site 1173027004494 Domain of unknown function DUF11; Region: DUF11; cl17728 1173027004495 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1173027004496 pseudouridine synthase; Region: TIGR00093 1173027004497 active site 1173027004498 Double zinc ribbon; Region: DZR; pfam12773 1173027004499 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173027004500 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027004501 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 1173027004502 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173027004503 active site 1173027004504 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027004505 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027004506 phosphopeptide binding site; other site 1173027004507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004508 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004509 active site 1173027004510 ATP binding site [chemical binding]; other site 1173027004511 substrate binding site [chemical binding]; other site 1173027004512 activation loop (A-loop); other site 1173027004513 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173027004514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027004515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027004516 NAD(P) binding site [chemical binding]; other site 1173027004517 active site 1173027004518 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1173027004519 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1173027004520 active site 1173027004521 catalytic residues [active] 1173027004522 metal binding site [ion binding]; metal-binding site 1173027004523 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1173027004524 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027004525 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027004526 catalytic loop [active] 1173027004527 iron binding site [ion binding]; other site 1173027004528 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004529 putative active site [active] 1173027004530 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173027004531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027004532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027004533 catalytic residue [active] 1173027004534 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173027004535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027004536 Walker A/P-loop; other site 1173027004537 ATP binding site [chemical binding]; other site 1173027004538 Q-loop/lid; other site 1173027004539 ABC transporter signature motif; other site 1173027004540 Walker B; other site 1173027004541 D-loop; other site 1173027004542 H-loop/switch region; other site 1173027004543 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027004544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004545 active site 1173027004546 phosphorylation site [posttranslational modification] 1173027004547 intermolecular recognition site; other site 1173027004548 dimerization interface [polypeptide binding]; other site 1173027004549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027004550 DNA binding site [nucleotide binding] 1173027004551 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1173027004552 putative GSH binding site [chemical binding]; other site 1173027004553 catalytic residues [active] 1173027004554 BolA-like protein; Region: BolA; pfam01722 1173027004555 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173027004556 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 1173027004557 active site 1173027004558 catalytic triad [active] 1173027004559 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1173027004560 Predicted membrane protein [Function unknown]; Region: COG3463 1173027004561 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1173027004562 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1173027004563 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027004564 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027004565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027004566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027004567 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1173027004568 active site 1173027004569 metal binding site [ion binding]; metal-binding site 1173027004570 Phosphate acyltransferases; Region: PlsC; smart00563 1173027004571 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1173027004572 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173027004573 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173027004574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173027004575 Transporter associated domain; Region: CorC_HlyC; smart01091 1173027004576 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1173027004577 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1173027004578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027004579 ATP binding site [chemical binding]; other site 1173027004580 putative Mg++ binding site [ion binding]; other site 1173027004581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027004582 nucleotide binding region [chemical binding]; other site 1173027004583 ATP-binding site [chemical binding]; other site 1173027004584 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1173027004585 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173027004586 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027004587 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027004589 Walker A motif; other site 1173027004590 ATP binding site [chemical binding]; other site 1173027004591 Walker B motif; other site 1173027004592 arginine finger; other site 1173027004593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027004594 Walker A motif; other site 1173027004595 ATP binding site [chemical binding]; other site 1173027004596 Walker B motif; other site 1173027004597 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173027004598 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004599 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004602 RNA methyltransferase, RsmE family; Region: TIGR00046 1173027004603 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1173027004604 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1173027004605 Haemolytic domain; Region: Haemolytic; pfam01809 1173027004606 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027004607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027004608 DNA binding residues [nucleotide binding] 1173027004609 dimerization interface [polypeptide binding]; other site 1173027004610 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173027004611 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1173027004612 putative substrate binding site [chemical binding]; other site 1173027004613 putative ATP binding site [chemical binding]; other site 1173027004614 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1173027004615 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1173027004616 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173027004617 FMN binding site [chemical binding]; other site 1173027004618 active site 1173027004619 catalytic residues [active] 1173027004620 substrate binding site [chemical binding]; other site 1173027004621 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1173027004622 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1173027004623 putative active site cavity [active] 1173027004624 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1173027004625 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173027004626 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173027004627 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027004628 conserved hypothetical protein; Region: TIGR02231 1173027004629 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1173027004630 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1173027004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004632 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004633 active site 1173027004634 phosphorylation site [posttranslational modification] 1173027004635 intermolecular recognition site; other site 1173027004636 dimerization interface [polypeptide binding]; other site 1173027004637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027004638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027004639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027004640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027004641 dimer interface [polypeptide binding]; other site 1173027004642 phosphorylation site [posttranslational modification] 1173027004643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027004644 ATP binding site [chemical binding]; other site 1173027004645 Mg2+ binding site [ion binding]; other site 1173027004646 G-X-G motif; other site 1173027004647 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004649 active site 1173027004650 phosphorylation site [posttranslational modification] 1173027004651 intermolecular recognition site; other site 1173027004652 dimerization interface [polypeptide binding]; other site 1173027004653 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1173027004654 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027004655 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027004656 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027004657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027004658 catalytic loop [active] 1173027004659 iron binding site [ion binding]; other site 1173027004660 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004661 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004663 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004664 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004665 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004666 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027004667 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027004668 Lipase (class 2); Region: Lipase_2; pfam01674 1173027004669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027004670 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027004671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027004672 TPR motif; other site 1173027004673 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1173027004674 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1173027004675 active site 1173027004676 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173027004677 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173027004678 active site 1173027004679 (T/H)XGH motif; other site 1173027004680 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173027004681 nudix motif; other site 1173027004682 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1173027004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1173027004684 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173027004685 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173027004686 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027004687 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 1173027004688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027004689 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1173027004690 Putative restriction endonuclease; Region: Uma2; pfam05685 1173027004691 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173027004692 Fasciclin domain; Region: Fasciclin; pfam02469 1173027004693 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1173027004694 Caspase domain; Region: Peptidase_C14; pfam00656 1173027004695 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1173027004696 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004697 putative active site [active] 1173027004698 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1173027004699 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1173027004700 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1173027004701 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027004702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027004703 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1173027004704 FtsX-like permease family; Region: FtsX; pfam02687 1173027004705 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173027004706 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 1173027004707 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173027004708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173027004709 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173027004710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173027004711 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004712 structural tetrad; other site 1173027004713 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027004714 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004715 structural tetrad; other site 1173027004716 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004717 structural tetrad; other site 1173027004718 XisI protein; Region: XisI; pfam08869 1173027004719 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173027004720 active site 1173027004721 SAM binding site [chemical binding]; other site 1173027004722 homodimer interface [polypeptide binding]; other site 1173027004723 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1173027004724 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1173027004725 active site 1173027004726 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027004727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027004728 PAS domain S-box; Region: sensory_box; TIGR00229 1173027004729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027004730 putative active site [active] 1173027004731 heme pocket [chemical binding]; other site 1173027004732 PAS fold; Region: PAS_4; pfam08448 1173027004733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027004734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027004735 metal binding site [ion binding]; metal-binding site 1173027004736 active site 1173027004737 I-site; other site 1173027004738 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173027004739 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027004740 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027004741 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1173027004742 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1173027004743 NAD(P) binding site [chemical binding]; other site 1173027004744 catalytic residues [active] 1173027004745 dephospho-CoA kinase; Region: TIGR00152 1173027004746 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1173027004747 CoA-binding site [chemical binding]; other site 1173027004748 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004749 putative active site [active] 1173027004750 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173027004751 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027004752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027004753 catalytic residue [active] 1173027004754 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027004755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027004756 active site 1173027004757 phosphorylation site [posttranslational modification] 1173027004758 intermolecular recognition site; other site 1173027004759 dimerization interface [polypeptide binding]; other site 1173027004760 major vault protein; Provisional; Region: PTZ00491 1173027004761 Major Vault Protein repeat; Region: Vault; pfam01505 1173027004762 Major Vault Protein repeat; Region: Vault; pfam01505 1173027004763 Major Vault Protein repeat; Region: Vault; pfam01505 1173027004764 Major Vault Protein repeat; Region: Vault; pfam01505 1173027004765 Shoulder domain; Region: MVP_shoulder; pfam11978 1173027004766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027004767 dimerization interface [polypeptide binding]; other site 1173027004768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027004769 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027004770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027004771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027004772 dimer interface [polypeptide binding]; other site 1173027004773 putative CheW interface [polypeptide binding]; other site 1173027004774 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173027004775 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173027004776 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173027004777 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1173027004778 Part of AAA domain; Region: AAA_19; pfam13245 1173027004779 Family description; Region: UvrD_C_2; pfam13538 1173027004780 AAA ATPase domain; Region: AAA_16; pfam13191 1173027004781 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004782 putative active site [active] 1173027004783 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173027004784 heme binding pocket [chemical binding]; other site 1173027004785 heme ligand [chemical binding]; other site 1173027004786 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173027004787 diiron binding motif [ion binding]; other site 1173027004788 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027004789 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173027004790 Hexamer interface [polypeptide binding]; other site 1173027004791 Hexagonal pore residue; other site 1173027004792 heat shock protein HtpX; Provisional; Region: PRK03982 1173027004793 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 1173027004794 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027004795 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173027004796 active site 1173027004797 DNA binding site [nucleotide binding] 1173027004798 Int/Topo IB signature motif; other site 1173027004799 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027004800 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173027004801 putative acyl-acceptor binding pocket; other site 1173027004802 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027004803 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027004804 active site 1173027004805 metal binding site [ion binding]; metal-binding site 1173027004806 putative acyl transferase; Provisional; Region: PRK10502 1173027004807 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1173027004808 putative trimer interface [polypeptide binding]; other site 1173027004809 putative active site [active] 1173027004810 putative substrate binding site [chemical binding]; other site 1173027004811 putative CoA binding site [chemical binding]; other site 1173027004812 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027004813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027004814 PAS domain; Region: PAS_9; pfam13426 1173027004815 putative active site [active] 1173027004816 heme pocket [chemical binding]; other site 1173027004817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027004818 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027004819 non-specific DNA interactions [nucleotide binding]; other site 1173027004820 DNA binding site [nucleotide binding] 1173027004821 sequence specific DNA binding site [nucleotide binding]; other site 1173027004822 putative cAMP binding site [chemical binding]; other site 1173027004823 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1173027004824 hypothetical protein; Reviewed; Region: PRK09588 1173027004825 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027004826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027004827 S-adenosylmethionine binding site [chemical binding]; other site 1173027004828 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173027004829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027004830 motif II; other site 1173027004831 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1173027004832 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1173027004833 catalytic motif [active] 1173027004834 Zn binding site [ion binding]; other site 1173027004835 RibD C-terminal domain; Region: RibD_C; cl17279 1173027004836 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027004837 putative active site [active] 1173027004838 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027004839 active site 1173027004840 NTP binding site [chemical binding]; other site 1173027004841 metal binding triad [ion binding]; metal-binding site 1173027004842 antibiotic binding site [chemical binding]; other site 1173027004843 Protein of unknown function DUF86; Region: DUF86; cl01031 1173027004844 Caspase domain; Region: Peptidase_C14; pfam00656 1173027004845 GUN4-like; Region: GUN4; pfam05419 1173027004846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004848 active site 1173027004849 ATP binding site [chemical binding]; other site 1173027004850 substrate binding site [chemical binding]; other site 1173027004851 activation loop (A-loop); other site 1173027004852 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027004853 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027004854 structural tetrad; other site 1173027004855 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173027004856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027004857 motif II; other site 1173027004858 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1173027004859 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1173027004860 rod shape-determining protein MreC; Provisional; Region: PRK13922 1173027004861 rod shape-determining protein MreC; Region: MreC; pfam04085 1173027004862 rod shape-determining protein MreB; Provisional; Region: PRK13927 1173027004863 MreB and similar proteins; Region: MreB_like; cd10225 1173027004864 nucleotide binding site [chemical binding]; other site 1173027004865 Mg binding site [ion binding]; other site 1173027004866 putative protofilament interaction site [polypeptide binding]; other site 1173027004867 RodZ interaction site [polypeptide binding]; other site 1173027004868 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173027004869 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173027004870 ssDNA binding site [nucleotide binding]; other site 1173027004871 dimer interface [polypeptide binding]; other site 1173027004872 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027004873 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1173027004874 EVE domain; Region: EVE; pfam01878 1173027004875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173027004876 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173027004877 AMIN domain; Region: AMIN; pfam11741 1173027004878 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027004879 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027004880 active site 1173027004881 metal binding site [ion binding]; metal-binding site 1173027004882 glutamate racemase; Provisional; Region: PRK00865 1173027004883 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173027004884 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173027004885 substrate binding pocket [chemical binding]; other site 1173027004886 chain length determination region; other site 1173027004887 substrate-Mg2+ binding site; other site 1173027004888 catalytic residues [active] 1173027004889 aspartate-rich region 1; other site 1173027004890 active site lid residues [active] 1173027004891 aspartate-rich region 2; other site 1173027004892 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1173027004893 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173027004894 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1173027004895 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173027004896 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173027004897 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173027004898 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027004899 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027004900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027004901 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027004902 putative active site [active] 1173027004903 heme pocket [chemical binding]; other site 1173027004904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027004905 putative active site [active] 1173027004906 heme pocket [chemical binding]; other site 1173027004907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027004908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027004909 metal binding site [ion binding]; metal-binding site 1173027004910 active site 1173027004911 I-site; other site 1173027004912 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173027004913 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173027004914 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173027004915 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1173027004916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027004917 FeS/SAM binding site; other site 1173027004918 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1173027004919 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1173027004920 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1173027004921 molybdopterin cofactor binding site; other site 1173027004922 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1173027004923 putative molybdopterin cofactor binding site; other site 1173027004924 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1173027004925 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173027004926 Walker A/P-loop; other site 1173027004927 ATP binding site [chemical binding]; other site 1173027004928 Q-loop/lid; other site 1173027004929 ABC transporter signature motif; other site 1173027004930 Walker B; other site 1173027004931 D-loop; other site 1173027004932 H-loop/switch region; other site 1173027004933 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1173027004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027004935 dimer interface [polypeptide binding]; other site 1173027004936 conserved gate region; other site 1173027004937 putative PBP binding loops; other site 1173027004938 ABC-ATPase subunit interface; other site 1173027004939 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173027004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027004941 dimer interface [polypeptide binding]; other site 1173027004942 conserved gate region; other site 1173027004943 putative PBP binding loops; other site 1173027004944 ABC-ATPase subunit interface; other site 1173027004945 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1173027004946 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173027004947 XisH protein; Region: XisH; pfam08814 1173027004948 XisI protein; Region: XisI; pfam08869 1173027004949 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173027004950 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173027004951 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173027004952 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1173027004953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173027004954 N-terminal plug; other site 1173027004955 ligand-binding site [chemical binding]; other site 1173027004956 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1173027004957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173027004958 MORN repeat; Region: MORN; cl14787 1173027004959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1173027004960 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 1173027004961 MORN repeat; Region: MORN; cl14787 1173027004962 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173027004963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173027004964 ABC-ATPase subunit interface; other site 1173027004965 dimer interface [polypeptide binding]; other site 1173027004966 putative PBP binding regions; other site 1173027004967 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173027004968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173027004969 ABC-ATPase subunit interface; other site 1173027004970 dimer interface [polypeptide binding]; other site 1173027004971 putative PBP binding regions; other site 1173027004972 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173027004973 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173027004974 Walker A/P-loop; other site 1173027004975 ATP binding site [chemical binding]; other site 1173027004976 Q-loop/lid; other site 1173027004977 ABC transporter signature motif; other site 1173027004978 Walker B; other site 1173027004979 D-loop; other site 1173027004980 H-loop/switch region; other site 1173027004981 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 1173027004982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027004983 dimerization interface [polypeptide binding]; other site 1173027004984 putative DNA binding site [nucleotide binding]; other site 1173027004985 putative Zn2+ binding site [ion binding]; other site 1173027004986 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027004987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027004988 S-adenosylmethionine binding site [chemical binding]; other site 1173027004989 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1173027004990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004992 active site 1173027004993 ATP binding site [chemical binding]; other site 1173027004994 substrate binding site [chemical binding]; other site 1173027004995 activation loop (A-loop); other site 1173027004996 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027004997 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027004998 active site 1173027004999 ATP binding site [chemical binding]; other site 1173027005000 substrate binding site [chemical binding]; other site 1173027005001 activation loop (A-loop); other site 1173027005002 CHASE3 domain; Region: CHASE3; pfam05227 1173027005003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005005 dimer interface [polypeptide binding]; other site 1173027005006 phosphorylation site [posttranslational modification] 1173027005007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005008 ATP binding site [chemical binding]; other site 1173027005009 G-X-G motif; other site 1173027005010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027005011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005012 active site 1173027005013 phosphorylation site [posttranslational modification] 1173027005014 intermolecular recognition site; other site 1173027005015 dimerization interface [polypeptide binding]; other site 1173027005016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027005017 DNA binding site [nucleotide binding] 1173027005018 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173027005019 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027005020 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173027005021 iron-sulfur cluster [ion binding]; other site 1173027005022 [2Fe-2S] cluster binding site [ion binding]; other site 1173027005023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027005024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027005025 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1173027005026 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173027005027 active site 1173027005028 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1173027005029 arsenical-resistance protein; Region: acr3; TIGR00832 1173027005030 PBP superfamily domain; Region: PBP_like_2; cl17296 1173027005031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027005032 dimerization interface [polypeptide binding]; other site 1173027005033 putative DNA binding site [nucleotide binding]; other site 1173027005034 putative Zn2+ binding site [ion binding]; other site 1173027005035 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027005036 dimer interface [polypeptide binding]; other site 1173027005037 [2Fe-2S] cluster binding site [ion binding]; other site 1173027005038 Peptidase family M48; Region: Peptidase_M48; cl12018 1173027005039 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027005040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005041 active site 1173027005042 phosphorylation site [posttranslational modification] 1173027005043 intermolecular recognition site; other site 1173027005044 dimerization interface [polypeptide binding]; other site 1173027005045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005047 dimer interface [polypeptide binding]; other site 1173027005048 phosphorylation site [posttranslational modification] 1173027005049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005050 ATP binding site [chemical binding]; other site 1173027005051 Mg2+ binding site [ion binding]; other site 1173027005052 G-X-G motif; other site 1173027005053 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027005054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005055 active site 1173027005056 phosphorylation site [posttranslational modification] 1173027005057 intermolecular recognition site; other site 1173027005058 dimerization interface [polypeptide binding]; other site 1173027005059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027005060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005061 active site 1173027005062 phosphorylation site [posttranslational modification] 1173027005063 intermolecular recognition site; other site 1173027005064 dimerization interface [polypeptide binding]; other site 1173027005065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027005066 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1173027005067 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027005068 HSP70 interaction site [polypeptide binding]; other site 1173027005069 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027005070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005072 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027005074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027005075 ligand binding site [chemical binding]; other site 1173027005076 flexible hinge region; other site 1173027005077 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1173027005078 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1173027005079 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1173027005080 protein binding site [polypeptide binding]; other site 1173027005081 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1173027005082 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173027005083 Probable Catalytic site; other site 1173027005084 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1173027005085 quinolinate synthetase; Provisional; Region: PRK09375 1173027005086 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 1173027005087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027005088 putative active site [active] 1173027005089 putative metal binding site [ion binding]; other site 1173027005090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027005091 non-specific DNA binding site [nucleotide binding]; other site 1173027005092 salt bridge; other site 1173027005093 sequence-specific DNA binding site [nucleotide binding]; other site 1173027005094 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173027005095 putative active site [active] 1173027005096 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1173027005097 carotene isomerase; Region: carot_isom; TIGR02730 1173027005098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027005099 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1173027005100 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 1173027005101 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1173027005102 Uncharacterized conserved protein [Function unknown]; Region: COG4021 1173027005103 Thg1 C terminal domain; Region: Thg1C; pfam14413 1173027005104 AAA domain; Region: AAA_33; pfam13671 1173027005105 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1173027005106 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1173027005107 thiamine phosphate binding site [chemical binding]; other site 1173027005108 active site 1173027005109 pyrophosphate binding site [ion binding]; other site 1173027005110 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1173027005111 thiS-thiF/thiG interaction site; other site 1173027005112 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 1173027005113 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173027005115 putative active site [active] 1173027005116 heme pocket [chemical binding]; other site 1173027005117 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005118 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005120 putative active site [active] 1173027005121 heme pocket [chemical binding]; other site 1173027005122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005123 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005124 putative active site [active] 1173027005125 heme pocket [chemical binding]; other site 1173027005126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005127 putative active site [active] 1173027005128 heme pocket [chemical binding]; other site 1173027005129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005131 dimer interface [polypeptide binding]; other site 1173027005132 phosphorylation site [posttranslational modification] 1173027005133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005134 ATP binding site [chemical binding]; other site 1173027005135 Mg2+ binding site [ion binding]; other site 1173027005136 G-X-G motif; other site 1173027005137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027005138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005139 active site 1173027005140 phosphorylation site [posttranslational modification] 1173027005141 intermolecular recognition site; other site 1173027005142 dimerization interface [polypeptide binding]; other site 1173027005143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027005144 DNA binding site [nucleotide binding] 1173027005145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027005147 dimerization interface [polypeptide binding]; other site 1173027005148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005149 dimer interface [polypeptide binding]; other site 1173027005150 phosphorylation site [posttranslational modification] 1173027005151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005152 ATP binding site [chemical binding]; other site 1173027005153 Mg2+ binding site [ion binding]; other site 1173027005154 G-X-G motif; other site 1173027005155 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1173027005156 active site 1173027005157 SAM binding site [chemical binding]; other site 1173027005158 homodimer interface [polypeptide binding]; other site 1173027005159 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027005160 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027005161 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1173027005162 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 1173027005163 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027005164 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027005165 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027005166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005167 active site 1173027005168 ATP binding site [chemical binding]; other site 1173027005169 substrate binding site [chemical binding]; other site 1173027005170 activation loop (A-loop); other site 1173027005171 AAA ATPase domain; Region: AAA_16; pfam13191 1173027005172 Predicted ATPase [General function prediction only]; Region: COG3899 1173027005173 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005174 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005175 PAS fold; Region: PAS_4; pfam08448 1173027005176 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173027005177 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005179 putative active site [active] 1173027005180 heme pocket [chemical binding]; other site 1173027005181 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005183 putative active site [active] 1173027005184 heme pocket [chemical binding]; other site 1173027005185 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027005186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005187 putative active site [active] 1173027005188 heme pocket [chemical binding]; other site 1173027005189 Histidine kinase; Region: HisKA_3; pfam07730 1173027005190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005191 ATP binding site [chemical binding]; other site 1173027005192 Mg2+ binding site [ion binding]; other site 1173027005193 G-X-G motif; other site 1173027005194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027005195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005196 active site 1173027005197 phosphorylation site [posttranslational modification] 1173027005198 intermolecular recognition site; other site 1173027005199 dimerization interface [polypeptide binding]; other site 1173027005200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027005201 dimerization interface [polypeptide binding]; other site 1173027005202 DNA binding residues [nucleotide binding] 1173027005203 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173027005204 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1173027005205 Thioredoxin; Region: Thioredoxin_4; cl17273 1173027005206 CAAX protease self-immunity; Region: Abi; pfam02517 1173027005207 CAAX protease self-immunity; Region: Abi; pfam02517 1173027005208 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1173027005209 Thioesterase domain; Region: Thioesterase; pfam00975 1173027005210 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1173027005211 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1173027005212 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027005213 Cytochrome P450; Region: p450; cl12078 1173027005214 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1173027005215 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027005216 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173027005217 acyl-activating enzyme (AAE) consensus motif; other site 1173027005218 AMP binding site [chemical binding]; other site 1173027005219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005220 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173027005221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173027005222 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1173027005223 active site 1173027005224 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173027005225 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173027005226 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173027005227 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173027005228 putative NADP binding site [chemical binding]; other site 1173027005229 active site 1173027005230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005231 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027005232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027005233 catalytic residue [active] 1173027005234 Condensation domain; Region: Condensation; pfam00668 1173027005235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027005236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027005237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173027005238 acyl-activating enzyme (AAE) consensus motif; other site 1173027005239 AMP binding site [chemical binding]; other site 1173027005240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005241 Condensation domain; Region: Condensation; pfam00668 1173027005242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027005243 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1173027005244 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1173027005245 acyl-activating enzyme (AAE) consensus motif; other site 1173027005246 AMP binding site [chemical binding]; other site 1173027005247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005248 Condensation domain; Region: Condensation; pfam00668 1173027005249 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027005250 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027005251 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173027005252 acyl-activating enzyme (AAE) consensus motif; other site 1173027005253 AMP binding site [chemical binding]; other site 1173027005254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005255 Condensation domain; Region: Condensation; pfam00668 1173027005256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027005257 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173027005258 FkbH-like domain; Region: FkbH; TIGR01686 1173027005259 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 1173027005260 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173027005261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173027005262 active site 1173027005263 acyl carrier protein; Provisional; Region: PRK07081 1173027005264 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1173027005265 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1173027005266 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1173027005267 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173027005268 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1173027005269 active site 1173027005270 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173027005271 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173027005272 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173027005273 putative NADP binding site [chemical binding]; other site 1173027005274 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173027005275 active site 1173027005276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005277 Condensation domain; Region: Condensation; pfam00668 1173027005278 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027005279 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1173027005280 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1173027005281 acyl-activating enzyme (AAE) consensus motif; other site 1173027005282 AMP binding site [chemical binding]; other site 1173027005283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027005284 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1173027005285 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1173027005286 active site 1173027005287 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173027005288 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1173027005289 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1173027005290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173027005291 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1173027005292 acyl-activating enzyme (AAE) consensus motif; other site 1173027005293 AMP binding site [chemical binding]; other site 1173027005294 active site 1173027005295 CoA binding site [chemical binding]; other site 1173027005296 salicylate synthase; Region: salicyl_syn; TIGR03494 1173027005297 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173027005298 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1173027005299 AMIN domain; Region: AMIN; pfam11741 1173027005300 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173027005301 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173027005302 N-terminal plug; other site 1173027005303 ligand-binding site [chemical binding]; other site 1173027005304 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173027005305 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173027005306 siderophore binding site; other site 1173027005307 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1173027005308 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173027005309 DNA binding residues [nucleotide binding] 1173027005310 dimer interface [polypeptide binding]; other site 1173027005311 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 1173027005312 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1173027005313 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1173027005314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027005315 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173027005316 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173027005317 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1173027005318 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1173027005319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027005320 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1173027005321 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027005322 active site 1173027005323 catalytic residues [active] 1173027005324 DNA binding site [nucleotide binding] 1173027005325 Int/Topo IB signature motif; other site 1173027005326 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005327 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005329 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027005330 putative active site [active] 1173027005331 heme pocket [chemical binding]; other site 1173027005332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005333 putative active site [active] 1173027005334 heme pocket [chemical binding]; other site 1173027005335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005336 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005337 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005338 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005339 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005342 dimer interface [polypeptide binding]; other site 1173027005343 phosphorylation site [posttranslational modification] 1173027005344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005345 ATP binding site [chemical binding]; other site 1173027005346 Mg2+ binding site [ion binding]; other site 1173027005347 G-X-G motif; other site 1173027005348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005349 PAS domain; Region: PAS_9; pfam13426 1173027005350 putative active site [active] 1173027005351 heme pocket [chemical binding]; other site 1173027005352 PAS domain S-box; Region: sensory_box; TIGR00229 1173027005353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005354 putative active site [active] 1173027005355 heme pocket [chemical binding]; other site 1173027005356 PAS fold; Region: PAS_4; pfam08448 1173027005357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005358 putative active site [active] 1173027005359 heme pocket [chemical binding]; other site 1173027005360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005362 ATP binding site [chemical binding]; other site 1173027005363 Mg2+ binding site [ion binding]; other site 1173027005364 G-X-G motif; other site 1173027005365 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173027005366 classical (c) SDRs; Region: SDR_c; cd05233 1173027005367 NAD(P) binding site [chemical binding]; other site 1173027005368 active site 1173027005369 putative pectinesterase; Region: PLN02432; cl01911 1173027005370 Right handed beta helix region; Region: Beta_helix; pfam13229 1173027005371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173027005372 AAA ATPase domain; Region: AAA_16; pfam13191 1173027005373 Walker A motif; other site 1173027005374 ATP binding site [chemical binding]; other site 1173027005375 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173027005376 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027005377 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173027005378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027005379 ATP binding site [chemical binding]; other site 1173027005380 putative Mg++ binding site [ion binding]; other site 1173027005381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027005382 nucleotide binding region [chemical binding]; other site 1173027005383 ATP-binding site [chemical binding]; other site 1173027005384 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1173027005385 HRDC domain; Region: HRDC; pfam00570 1173027005386 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1173027005387 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027005388 cofactor binding site; other site 1173027005389 DNA binding site [nucleotide binding] 1173027005390 substrate interaction site [chemical binding]; other site 1173027005391 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027005392 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1173027005393 GIY-YIG motif/motif A; other site 1173027005394 active site 1173027005395 catalytic site [active] 1173027005396 metal binding site [ion binding]; metal-binding site 1173027005397 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027005398 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027005399 putative active site [active] 1173027005400 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027005401 WD40 repeats; Region: WD40; smart00320 1173027005402 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027005403 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027005404 structural tetrad; other site 1173027005405 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027005406 structural tetrad; other site 1173027005407 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027005408 WD40 repeats; Region: WD40; smart00320 1173027005409 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173027005410 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027005411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027005412 active site 1173027005413 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1173027005414 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027005415 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173027005416 Walker A/P-loop; other site 1173027005417 ATP binding site [chemical binding]; other site 1173027005418 Q-loop/lid; other site 1173027005419 ABC transporter signature motif; other site 1173027005420 Walker B; other site 1173027005421 D-loop; other site 1173027005422 H-loop/switch region; other site 1173027005423 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1173027005424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005425 PAS domain; Region: PAS_9; pfam13426 1173027005426 putative active site [active] 1173027005427 heme pocket [chemical binding]; other site 1173027005428 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005429 GAF domain; Region: GAF; cl17456 1173027005430 PAS domain S-box; Region: sensory_box; TIGR00229 1173027005431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005432 putative active site [active] 1173027005433 heme pocket [chemical binding]; other site 1173027005434 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027005435 cyclase homology domain; Region: CHD; cd07302 1173027005436 nucleotidyl binding site; other site 1173027005437 metal binding site [ion binding]; metal-binding site 1173027005438 dimer interface [polypeptide binding]; other site 1173027005439 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173027005440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027005441 NAD(P) binding site [chemical binding]; other site 1173027005442 active site 1173027005443 Peptidase M15; Region: Peptidase_M15_3; cl01194 1173027005444 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1173027005445 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1173027005446 catalytic residues [active] 1173027005447 Helix-turn-helix domain; Region: HTH_25; pfam13413 1173027005448 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1173027005449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027005450 active site 1173027005451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027005452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005453 active site 1173027005454 ATP binding site [chemical binding]; other site 1173027005455 substrate binding site [chemical binding]; other site 1173027005456 activation loop (A-loop); other site 1173027005457 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1173027005458 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1173027005459 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173027005460 metal ion-dependent adhesion site (MIDAS); other site 1173027005461 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1173027005462 CAAX protease self-immunity; Region: Abi; pfam02517 1173027005463 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1173027005464 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173027005465 metal binding site [ion binding]; metal-binding site 1173027005466 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1173027005467 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027005468 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173027005469 metal binding site [ion binding]; metal-binding site 1173027005470 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173027005471 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1173027005472 GTP1/OBG; Region: GTP1_OBG; pfam01018 1173027005473 Obg GTPase; Region: Obg; cd01898 1173027005474 G1 box; other site 1173027005475 GTP/Mg2+ binding site [chemical binding]; other site 1173027005476 Switch I region; other site 1173027005477 G2 box; other site 1173027005478 G3 box; other site 1173027005479 Switch II region; other site 1173027005480 G4 box; other site 1173027005481 G5 box; other site 1173027005482 EamA-like transporter family; Region: EamA; pfam00892 1173027005483 EamA-like transporter family; Region: EamA; pfam00892 1173027005484 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173027005485 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173027005486 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1173027005487 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1173027005488 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1173027005489 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 1173027005490 active site 1173027005491 dimer interface [polypeptide binding]; other site 1173027005492 catalytic nucleophile [active] 1173027005493 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027005494 putative active site [active] 1173027005495 Predicted esterase [General function prediction only]; Region: COG0400 1173027005496 putative hydrolase; Provisional; Region: PRK11460 1173027005497 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173027005498 Walker A/P-loop; other site 1173027005499 ATP binding site [chemical binding]; other site 1173027005500 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173027005501 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1173027005502 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173027005503 ABC transporter signature motif; other site 1173027005504 Walker B; other site 1173027005505 D-loop; other site 1173027005506 H-loop/switch region; other site 1173027005507 PRC-barrel domain; Region: PRC; pfam05239 1173027005508 putative anti-sigmaE protein; Provisional; Region: PRK13920 1173027005509 RNA polymerase sigma factor; Provisional; Region: PRK12519 1173027005510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027005511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027005512 DNA binding residues [nucleotide binding] 1173027005513 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173027005514 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173027005515 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173027005516 Moco binding site; other site 1173027005517 metal coordination site [ion binding]; other site 1173027005518 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1173027005519 MltA specific insert domain; Region: MltA; pfam03562 1173027005520 3D domain; Region: 3D; pfam06725 1173027005521 AAA ATPase domain; Region: AAA_16; pfam13191 1173027005522 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173027005523 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027005524 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027005525 structural tetrad; other site 1173027005526 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027005527 structural tetrad; other site 1173027005528 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027005529 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027005530 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1173027005531 Class I aldolases; Region: Aldolase_Class_I; cl17187 1173027005532 catalytic residue [active] 1173027005533 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173027005534 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173027005535 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173027005536 putative dimer interface [polypeptide binding]; other site 1173027005537 N-terminal domain interface [polypeptide binding]; other site 1173027005538 putative substrate binding pocket (H-site) [chemical binding]; other site 1173027005539 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173027005540 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173027005541 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027005542 Cytochrome P450; Region: p450; pfam00067 1173027005543 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1173027005544 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173027005545 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173027005546 inhibitor-cofactor binding pocket; inhibition site 1173027005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027005548 catalytic residue [active] 1173027005549 Protein of unknown function (DUF561); Region: DUF561; pfam04481 1173027005550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027005551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005552 active site 1173027005553 ATP binding site [chemical binding]; other site 1173027005554 substrate binding site [chemical binding]; other site 1173027005555 activation loop (A-loop); other site 1173027005556 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 1173027005557 ligand binding surface [chemical binding]; other site 1173027005558 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173027005559 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173027005560 putative di-iron ligands [ion binding]; other site 1173027005561 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173027005562 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 1173027005563 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1173027005564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027005565 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027005566 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005567 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027005568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005571 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027005576 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173027005577 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1173027005578 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1173027005579 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173027005580 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027005581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173027005582 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1173027005583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005585 dimer interface [polypeptide binding]; other site 1173027005586 phosphorylation site [posttranslational modification] 1173027005587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005588 ATP binding site [chemical binding]; other site 1173027005589 Mg2+ binding site [ion binding]; other site 1173027005590 G-X-G motif; other site 1173027005591 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1173027005592 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027005593 Chain length determinant protein; Region: Wzz; pfam02706 1173027005594 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1173027005595 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027005596 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1173027005597 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173027005598 O-Antigen ligase; Region: Wzy_C; pfam04932 1173027005599 Trm112p-like protein; Region: Trm112p; cl01066 1173027005600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027005601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027005602 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173027005603 putative ADP-binding pocket [chemical binding]; other site 1173027005604 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027005605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027005606 active site 1173027005607 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173027005608 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1173027005609 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1173027005610 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173027005611 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1173027005612 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1173027005613 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1173027005614 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1173027005615 trimer interface [polypeptide binding]; other site 1173027005616 active site 1173027005617 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1173027005618 catalytic site [active] 1173027005619 TPR repeat; Region: TPR_11; pfam13414 1173027005620 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1173027005621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005623 binding surface 1173027005624 TPR motif; other site 1173027005625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005628 binding surface 1173027005629 TPR motif; other site 1173027005630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005633 binding surface 1173027005634 TPR motif; other site 1173027005635 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005637 binding surface 1173027005638 TPR motif; other site 1173027005639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005642 binding surface 1173027005643 TPR motif; other site 1173027005644 CHAT domain; Region: CHAT; pfam12770 1173027005645 CHAT domain; Region: CHAT; pfam12770 1173027005646 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027005647 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027005648 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 1173027005649 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027005650 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027005651 putative active site [active] 1173027005652 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 1173027005653 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027005654 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027005655 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027005656 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173027005657 putative acyl-acceptor binding pocket; other site 1173027005658 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1173027005659 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173027005660 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173027005661 active site 1173027005662 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027005663 ABC1 family; Region: ABC1; pfam03109 1173027005664 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173027005665 active site 1173027005666 ATP binding site [chemical binding]; other site 1173027005667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027005668 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005669 active site 1173027005670 ATP binding site [chemical binding]; other site 1173027005671 substrate binding site [chemical binding]; other site 1173027005672 activation loop (A-loop); other site 1173027005673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005674 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173027005675 DHH family; Region: DHH; pfam01368 1173027005676 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027005677 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1173027005678 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173027005679 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173027005680 active site 1173027005681 NTP binding site [chemical binding]; other site 1173027005682 metal binding triad [ion binding]; metal-binding site 1173027005683 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173027005684 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173027005685 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 1173027005686 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1173027005687 homopentamer interface [polypeptide binding]; other site 1173027005688 active site 1173027005689 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173027005690 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173027005691 putative catalytic cysteine [active] 1173027005692 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173027005693 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173027005694 Di-iron ligands [ion binding]; other site 1173027005695 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1173027005696 Aluminium resistance protein; Region: Alum_res; pfam06838 1173027005697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027005698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005699 active site 1173027005700 phosphorylation site [posttranslational modification] 1173027005701 intermolecular recognition site; other site 1173027005702 dimerization interface [polypeptide binding]; other site 1173027005703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027005704 DNA binding site [nucleotide binding] 1173027005705 PAS fold; Region: PAS_4; pfam08448 1173027005706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173027005707 putative active site [active] 1173027005708 heme pocket [chemical binding]; other site 1173027005709 PAS domain S-box; Region: sensory_box; TIGR00229 1173027005710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005711 putative active site [active] 1173027005712 heme pocket [chemical binding]; other site 1173027005713 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173027005714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005715 putative active site [active] 1173027005716 heme pocket [chemical binding]; other site 1173027005717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005718 dimer interface [polypeptide binding]; other site 1173027005719 phosphorylation site [posttranslational modification] 1173027005720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005721 ATP binding site [chemical binding]; other site 1173027005722 Mg2+ binding site [ion binding]; other site 1173027005723 G-X-G motif; other site 1173027005724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027005725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005726 active site 1173027005727 ATP binding site [chemical binding]; other site 1173027005728 substrate binding site [chemical binding]; other site 1173027005729 activation loop (A-loop); other site 1173027005730 TPR repeat; Region: TPR_11; pfam13414 1173027005731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005732 binding surface 1173027005733 TPR motif; other site 1173027005734 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027005735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005736 binding surface 1173027005737 TPR motif; other site 1173027005738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005739 binding surface 1173027005740 TPR motif; other site 1173027005741 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173027005742 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027005743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173027005744 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027005745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1173027005746 conserved hypothetical protein; Region: TIGR03492 1173027005747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027005748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027005749 active site 1173027005750 ATP binding site [chemical binding]; other site 1173027005751 substrate binding site [chemical binding]; other site 1173027005752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027005753 substrate binding site [chemical binding]; other site 1173027005754 activation loop (A-loop); other site 1173027005755 activation loop (A-loop); other site 1173027005756 AAA ATPase domain; Region: AAA_16; pfam13191 1173027005757 Predicted ATPase [General function prediction only]; Region: COG3899 1173027005758 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005759 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005762 ATP binding site [chemical binding]; other site 1173027005763 Mg2+ binding site [ion binding]; other site 1173027005764 G-X-G motif; other site 1173027005765 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005767 active site 1173027005768 phosphorylation site [posttranslational modification] 1173027005769 intermolecular recognition site; other site 1173027005770 dimerization interface [polypeptide binding]; other site 1173027005771 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1173027005772 cyclase homology domain; Region: CHD; cd07302 1173027005773 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027005774 nucleotidyl binding site; other site 1173027005775 metal binding site [ion binding]; metal-binding site 1173027005776 dimer interface [polypeptide binding]; other site 1173027005777 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027005778 G1 box; other site 1173027005779 GTP/Mg2+ binding site [chemical binding]; other site 1173027005780 G2 box; other site 1173027005781 Switch I region; other site 1173027005782 G3 box; other site 1173027005783 Switch II region; other site 1173027005784 G4 box; other site 1173027005785 G5 box; other site 1173027005786 CheW-like domain; Region: CheW; pfam01584 1173027005787 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027005788 putative binding surface; other site 1173027005789 active site 1173027005790 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027005791 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027005792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005793 ATP binding site [chemical binding]; other site 1173027005794 Mg2+ binding site [ion binding]; other site 1173027005795 G-X-G motif; other site 1173027005796 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027005797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027005798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005799 active site 1173027005800 phosphorylation site [posttranslational modification] 1173027005801 intermolecular recognition site; other site 1173027005802 dimerization interface [polypeptide binding]; other site 1173027005803 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005804 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005808 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005812 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005815 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027005818 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027005819 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027005820 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; cl10712 1173027005821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027005822 dimer interface [polypeptide binding]; other site 1173027005823 putative CheW interface [polypeptide binding]; other site 1173027005824 CheW-like domain; Region: CheW; pfam01584 1173027005825 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005827 active site 1173027005828 phosphorylation site [posttranslational modification] 1173027005829 intermolecular recognition site; other site 1173027005830 dimerization interface [polypeptide binding]; other site 1173027005831 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027005832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027005833 active site 1173027005834 phosphorylation site [posttranslational modification] 1173027005835 intermolecular recognition site; other site 1173027005836 dimerization interface [polypeptide binding]; other site 1173027005837 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1173027005838 UreF; Region: UreF; pfam01730 1173027005839 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1173027005840 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1173027005841 dimer interface [polypeptide binding]; other site 1173027005842 catalytic residues [active] 1173027005843 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173027005844 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173027005845 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173027005846 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173027005847 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1173027005848 precorrin-8X methylmutase; Provisional; Region: PRK05954 1173027005849 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173027005850 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1173027005851 active site 1173027005852 putative homodimer interface [polypeptide binding]; other site 1173027005853 SAM binding site [chemical binding]; other site 1173027005854 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173027005855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027005856 S-adenosylmethionine binding site [chemical binding]; other site 1173027005857 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1173027005858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173027005859 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173027005860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1173027005861 Predicted integral membrane protein [Function unknown]; Region: COG0762 1173027005862 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 1173027005863 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173027005864 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1173027005865 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173027005866 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1173027005867 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 1173027005868 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173027005869 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027005870 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173027005871 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173027005872 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 1173027005873 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027005874 catalytic loop [active] 1173027005875 iron binding site [ion binding]; other site 1173027005876 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027005877 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173027005878 CAAX protease self-immunity; Region: Abi; pfam02517 1173027005879 CHAT domain; Region: CHAT; cl17868 1173027005880 TPR repeat; Region: TPR_11; pfam13414 1173027005881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005882 binding surface 1173027005883 TPR motif; other site 1173027005884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005886 binding surface 1173027005887 TPR motif; other site 1173027005888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005891 binding surface 1173027005892 TPR motif; other site 1173027005893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005894 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173027005895 Cache domain; Region: Cache_1; pfam02743 1173027005896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027005897 dimerization interface [polypeptide binding]; other site 1173027005898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027005899 PAS fold; Region: PAS_3; pfam08447 1173027005900 putative active site [active] 1173027005901 heme pocket [chemical binding]; other site 1173027005902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027005903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027005904 dimer interface [polypeptide binding]; other site 1173027005905 phosphorylation site [posttranslational modification] 1173027005906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027005907 ATP binding site [chemical binding]; other site 1173027005908 Mg2+ binding site [ion binding]; other site 1173027005909 G-X-G motif; other site 1173027005910 acetyl-CoA synthetase; Provisional; Region: PRK00174 1173027005911 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1173027005912 active site 1173027005913 CoA binding site [chemical binding]; other site 1173027005914 acyl-activating enzyme (AAE) consensus motif; other site 1173027005915 AMP binding site [chemical binding]; other site 1173027005916 acetate binding site [chemical binding]; other site 1173027005917 Putative restriction endonuclease; Region: Uma2; pfam05685 1173027005918 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027005919 putative active site [active] 1173027005920 magnesium chelatase subunit H; Provisional; Region: PRK12493 1173027005921 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027005922 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027005923 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173027005924 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 1173027005925 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 1173027005926 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173027005927 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173027005928 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027005929 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027005930 active site 1173027005931 metal binding site [ion binding]; metal-binding site 1173027005932 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027005933 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027005934 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027005935 cell division protein; Validated; Region: ftsH; CHL00176 1173027005936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027005937 Walker A motif; other site 1173027005938 ATP binding site [chemical binding]; other site 1173027005939 Walker B motif; other site 1173027005940 arginine finger; other site 1173027005941 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173027005942 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173027005943 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173027005944 CHAT domain; Region: CHAT; pfam12770 1173027005945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027005946 Walker A motif; other site 1173027005947 ATP binding site [chemical binding]; other site 1173027005948 Walker B motif; other site 1173027005949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005951 binding surface 1173027005952 TPR motif; other site 1173027005953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005955 TPR motif; other site 1173027005956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005957 binding surface 1173027005958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005959 TPR motif; other site 1173027005960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005961 binding surface 1173027005962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027005964 binding surface 1173027005965 TPR motif; other site 1173027005966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005967 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027005968 RTX C-terminal domain; Region: RTX_C; pfam08339 1173027005969 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1173027005970 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173027005971 C-terminal domain interface [polypeptide binding]; other site 1173027005972 active site 1173027005973 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173027005974 active site 1173027005975 N-terminal domain interface [polypeptide binding]; other site 1173027005976 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173027005977 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173027005978 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1173027005979 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); Region: ERGIC_N; pfam13850 1173027005980 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173027005981 active site 1173027005982 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 1173027005983 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027005984 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027005985 putative active site [active] 1173027005986 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027005987 FtsX-like permease family; Region: FtsX; pfam02687 1173027005988 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027005989 Cytochrome P450; Region: p450; pfam00067 1173027005990 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173027005991 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173027005992 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173027005993 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027005994 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1173027005995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027005996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027005997 putative substrate translocation pore; other site 1173027005998 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027005999 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173027006000 [2Fe-2S] cluster binding site [ion binding]; other site 1173027006001 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173027006002 hydrophobic ligand binding site; other site 1173027006003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027006004 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1173027006005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027006006 catalytic residue [active] 1173027006007 photosystem II protein K; Region: psbK; CHL00047 1173027006008 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027006009 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173027006010 putative C-terminal domain interface [polypeptide binding]; other site 1173027006011 putative GSH binding site (G-site) [chemical binding]; other site 1173027006012 putative dimer interface [polypeptide binding]; other site 1173027006013 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173027006014 N-terminal domain interface [polypeptide binding]; other site 1173027006015 dimer interface [polypeptide binding]; other site 1173027006016 substrate binding pocket (H-site) [chemical binding]; other site 1173027006017 TPR repeat; Region: TPR_11; pfam13414 1173027006018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006019 binding surface 1173027006020 TPR motif; other site 1173027006021 TPR repeat; Region: TPR_11; pfam13414 1173027006022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027006023 binding surface 1173027006024 TPR motif; other site 1173027006025 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 1173027006026 Integral membrane protein TerC family; Region: TerC; cl10468 1173027006027 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1173027006028 active site 1173027006029 multimer interface [polypeptide binding]; other site 1173027006030 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1173027006031 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1173027006032 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1173027006033 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1173027006034 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1173027006035 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1173027006036 NAD(P) binding site [chemical binding]; other site 1173027006037 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027006038 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1173027006039 lipoyl attachment site [posttranslational modification]; other site 1173027006040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027006041 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027006042 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027006043 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1173027006044 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1173027006045 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1173027006046 Isochorismatase family; Region: Isochorismatase; pfam00857 1173027006047 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173027006048 catalytic triad [active] 1173027006049 conserved cis-peptide bond; other site 1173027006050 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173027006051 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173027006052 catalytic triad [active] 1173027006053 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173027006054 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173027006055 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027006056 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173027006057 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173027006058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006059 TPR motif; other site 1173027006060 binding surface 1173027006061 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027006062 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027006063 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027006064 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173027006065 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173027006066 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173027006067 NodB motif; other site 1173027006068 active site 1173027006069 catalytic site [active] 1173027006070 metal binding site [ion binding]; metal-binding site 1173027006071 S-layer homology domain; Region: SLH; pfam00395 1173027006072 S-layer homology domain; Region: SLH; pfam00395 1173027006073 S-layer homology domain; Region: SLH; pfam00395 1173027006074 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173027006075 Cation efflux family; Region: Cation_efflux; cl00316 1173027006076 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173027006077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027006078 active site 1173027006079 motif I; other site 1173027006080 motif II; other site 1173027006081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027006082 DALR anticodon binding domain; Region: DALR_1; smart00836 1173027006083 anticodon binding site; other site 1173027006084 tRNA binding surface [nucleotide binding]; other site 1173027006085 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027006086 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027006087 putative switch regulator; other site 1173027006088 non-specific DNA interactions [nucleotide binding]; other site 1173027006089 DNA binding site [nucleotide binding] 1173027006090 sequence specific DNA binding site [nucleotide binding]; other site 1173027006091 putative cAMP binding site [chemical binding]; other site 1173027006092 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173027006093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027006094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006095 active site 1173027006096 phosphorylation site [posttranslational modification] 1173027006097 intermolecular recognition site; other site 1173027006098 dimerization interface [polypeptide binding]; other site 1173027006099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027006100 DNA binding site [nucleotide binding] 1173027006101 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027006102 putative binding surface; other site 1173027006103 active site 1173027006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006105 active site 1173027006106 phosphorylation site [posttranslational modification] 1173027006107 intermolecular recognition site; other site 1173027006108 dimerization interface [polypeptide binding]; other site 1173027006109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006110 active site 1173027006111 phosphorylation site [posttranslational modification] 1173027006112 intermolecular recognition site; other site 1173027006113 dimerization interface [polypeptide binding]; other site 1173027006114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006115 PAS domain; Region: PAS_9; pfam13426 1173027006116 putative active site [active] 1173027006117 heme pocket [chemical binding]; other site 1173027006118 PAS fold; Region: PAS_4; pfam08448 1173027006119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006120 putative active site [active] 1173027006121 heme pocket [chemical binding]; other site 1173027006122 PAS fold; Region: PAS_3; pfam08447 1173027006123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006124 PAS fold; Region: PAS_3; pfam08447 1173027006125 putative active site [active] 1173027006126 heme pocket [chemical binding]; other site 1173027006127 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006129 putative active site [active] 1173027006130 heme pocket [chemical binding]; other site 1173027006131 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027006132 GAF domain; Region: GAF; pfam01590 1173027006133 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173027006134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006135 putative active site [active] 1173027006136 heme pocket [chemical binding]; other site 1173027006137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006138 dimer interface [polypeptide binding]; other site 1173027006139 phosphorylation site [posttranslational modification] 1173027006140 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1173027006141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006142 ATP binding site [chemical binding]; other site 1173027006143 G-X-G motif; other site 1173027006144 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006146 active site 1173027006147 phosphorylation site [posttranslational modification] 1173027006148 intermolecular recognition site; other site 1173027006149 dimerization interface [polypeptide binding]; other site 1173027006150 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173027006151 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173027006152 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027006153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027006154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027006155 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027006156 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027006157 active site 1173027006158 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027006159 active site 1173027006160 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173027006161 Predicted transcriptional regulator [Transcription]; Region: COG3905 1173027006162 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1173027006163 putative active site [active] 1173027006164 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1173027006165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1173027006166 RibD C-terminal domain; Region: RibD_C; cl17279 1173027006167 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173027006168 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027006169 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173027006170 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027006171 Cupin domain; Region: Cupin_2; cl17218 1173027006172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027006173 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027006174 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173027006175 RibD C-terminal domain; Region: RibD_C; cl17279 1173027006176 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1173027006177 active site clefts [active] 1173027006178 zinc binding site [ion binding]; other site 1173027006179 dimer interface [polypeptide binding]; other site 1173027006180 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1173027006181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173027006182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027006183 Coenzyme A binding pocket [chemical binding]; other site 1173027006184 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1173027006185 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173027006186 active site 1173027006187 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1173027006188 catalytic triad [active] 1173027006189 hypothetical protein; Validated; Region: PRK00153 1173027006190 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1173027006191 FAD binding domain; Region: FAD_binding_4; pfam01565 1173027006192 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1173027006193 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1173027006194 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173027006195 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027006196 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173027006197 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173027006198 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173027006199 active site 1173027006200 (T/H)XGH motif; other site 1173027006201 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 1173027006202 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173027006203 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173027006204 thiamine monophosphate kinase; Provisional; Region: PRK05731 1173027006205 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1173027006206 ATP binding site [chemical binding]; other site 1173027006207 dimerization interface [polypeptide binding]; other site 1173027006208 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 1173027006209 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173027006210 active site 1173027006211 elongation factor P; Validated; Region: PRK00529 1173027006212 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1173027006213 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1173027006214 RNA binding site [nucleotide binding]; other site 1173027006215 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1173027006216 RNA binding site [nucleotide binding]; other site 1173027006217 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 1173027006218 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173027006219 carboxyltransferase (CT) interaction site; other site 1173027006220 biotinylation site [posttranslational modification]; other site 1173027006221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027006222 dimerization interface [polypeptide binding]; other site 1173027006223 putative DNA binding site [nucleotide binding]; other site 1173027006224 putative Zn2+ binding site [ion binding]; other site 1173027006225 Sporulation and spore germination; Region: Germane; pfam10646 1173027006226 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173027006227 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173027006228 putative catalytic site [active] 1173027006229 putative metal binding site [ion binding]; other site 1173027006230 putative phosphate binding site [ion binding]; other site 1173027006231 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1173027006232 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1173027006233 dimer interface [polypeptide binding]; other site 1173027006234 motif 1; other site 1173027006235 active site 1173027006236 motif 2; other site 1173027006237 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1173027006238 putative deacylase active site [active] 1173027006239 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173027006240 active site 1173027006241 motif 3; other site 1173027006242 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1173027006243 anticodon binding site; other site 1173027006244 TIR domain; Region: TIR_2; pfam13676 1173027006245 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1173027006246 aromatic arch; other site 1173027006247 DCoH dimer interaction site [polypeptide binding]; other site 1173027006248 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1173027006249 DCoH tetramer interaction site [polypeptide binding]; other site 1173027006250 substrate binding site [chemical binding]; other site 1173027006251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027006252 non-specific DNA binding site [nucleotide binding]; other site 1173027006253 salt bridge; other site 1173027006254 sequence-specific DNA binding site [nucleotide binding]; other site 1173027006255 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1173027006256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027006257 putative DNA binding site [nucleotide binding]; other site 1173027006258 putative Zn2+ binding site [ion binding]; other site 1173027006259 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173027006260 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1173027006261 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1173027006262 Na binding site [ion binding]; other site 1173027006263 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 1173027006264 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027006265 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1173027006266 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1173027006267 Chromate transporter; Region: Chromate_transp; pfam02417 1173027006268 MgtC family; Region: MgtC; pfam02308 1173027006269 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1173027006270 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1173027006271 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1173027006272 dimer interface [polypeptide binding]; other site 1173027006273 tetramer interface [polypeptide binding]; other site 1173027006274 PYR/PP interface [polypeptide binding]; other site 1173027006275 TPP binding site [chemical binding]; other site 1173027006276 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1173027006277 TPP-binding site; other site 1173027006278 Condensation domain; Region: Condensation; pfam00668 1173027006279 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027006280 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027006281 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173027006282 acyl-activating enzyme (AAE) consensus motif; other site 1173027006283 AMP binding site [chemical binding]; other site 1173027006284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027006285 bile acid transporter; Region: bass; TIGR00841 1173027006286 Sodium Bile acid symporter family; Region: SBF; cl17470 1173027006287 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173027006288 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027006289 active site 1173027006290 NTP binding site [chemical binding]; other site 1173027006291 metal binding triad [ion binding]; metal-binding site 1173027006292 antibiotic binding site [chemical binding]; other site 1173027006293 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1173027006294 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1173027006295 Condensation domain; Region: Condensation; pfam00668 1173027006296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027006297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027006298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173027006299 acyl-activating enzyme (AAE) consensus motif; other site 1173027006300 AMP binding site [chemical binding]; other site 1173027006301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027006302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027006303 S-adenosylmethionine binding site [chemical binding]; other site 1173027006304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173027006305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027006306 Cache domain; Region: Cache_1; pfam02743 1173027006307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027006308 dimerization interface [polypeptide binding]; other site 1173027006309 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027006310 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027006311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 1173027006312 Uncharacterized conserved protein [Function unknown]; Region: COG5439 1173027006313 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027006314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006315 putative active site [active] 1173027006316 heme pocket [chemical binding]; other site 1173027006317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006318 putative active site [active] 1173027006319 heme pocket [chemical binding]; other site 1173027006320 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1173027006321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027006322 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173027006323 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 1173027006324 Class II histocompatibility antigen, beta domain; Region: MHC_II_beta; cl03042 1173027006325 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027006326 putative active site [active] 1173027006327 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1173027006328 putative addiction module antidote; Region: doc_partner; TIGR02609 1173027006329 Condensation domain; Region: Condensation; pfam00668 1173027006330 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027006331 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027006332 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173027006333 acyl-activating enzyme (AAE) consensus motif; other site 1173027006334 AMP binding site [chemical binding]; other site 1173027006335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027006336 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173027006337 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1173027006338 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1173027006339 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 1173027006340 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173027006341 O-succinylbenzoate synthase; Provisional; Region: PRK02714 1173027006342 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1173027006343 active site 1173027006344 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 1173027006345 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1173027006346 acyl-activating enzyme (AAE) consensus motif; other site 1173027006347 putative AMP binding site [chemical binding]; other site 1173027006348 putative active site [active] 1173027006349 putative CoA binding site [chemical binding]; other site 1173027006350 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1173027006351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027006352 dimerization interface [polypeptide binding]; other site 1173027006353 Heme NO binding associated; Region: HNOBA; pfam07701 1173027006354 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027006355 cyclase homology domain; Region: CHD; cd07302 1173027006356 nucleotidyl binding site; other site 1173027006357 metal binding site [ion binding]; metal-binding site 1173027006358 dimer interface [polypeptide binding]; other site 1173027006359 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173027006360 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173027006361 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173027006362 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006364 putative active site [active] 1173027006365 heme pocket [chemical binding]; other site 1173027006366 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006368 putative active site [active] 1173027006369 heme pocket [chemical binding]; other site 1173027006370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006371 PAS fold; Region: PAS_3; pfam08447 1173027006372 putative active site [active] 1173027006373 heme pocket [chemical binding]; other site 1173027006374 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006376 putative active site [active] 1173027006377 heme pocket [chemical binding]; other site 1173027006378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006379 dimer interface [polypeptide binding]; other site 1173027006380 phosphorylation site [posttranslational modification] 1173027006381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006382 ATP binding site [chemical binding]; other site 1173027006383 Mg2+ binding site [ion binding]; other site 1173027006384 G-X-G motif; other site 1173027006385 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006387 active site 1173027006388 phosphorylation site [posttranslational modification] 1173027006389 intermolecular recognition site; other site 1173027006390 dimerization interface [polypeptide binding]; other site 1173027006391 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006393 active site 1173027006394 phosphorylation site [posttranslational modification] 1173027006395 intermolecular recognition site; other site 1173027006396 dimerization interface [polypeptide binding]; other site 1173027006397 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027006398 putative binding surface; other site 1173027006399 active site 1173027006400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027006401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027006402 active site 1173027006403 catalytic tetrad [active] 1173027006404 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 1173027006405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006406 active site 1173027006407 phosphorylation site [posttranslational modification] 1173027006408 intermolecular recognition site; other site 1173027006409 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 1173027006410 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1173027006411 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1173027006412 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1173027006413 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173027006414 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173027006415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027006416 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1173027006417 NAD binding site [chemical binding]; other site 1173027006418 homotetramer interface [polypeptide binding]; other site 1173027006419 homodimer interface [polypeptide binding]; other site 1173027006420 active site 1173027006421 substrate binding site [chemical binding]; other site 1173027006422 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027006423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027006424 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027006425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027006426 active site 1173027006427 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027006428 active site 1173027006429 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 1173027006430 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173027006431 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1173027006432 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 1173027006433 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027006434 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1173027006435 ligand binding site [chemical binding]; other site 1173027006436 flexible hinge region; other site 1173027006437 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027006438 putative switch regulator; other site 1173027006439 non-specific DNA interactions [nucleotide binding]; other site 1173027006440 DNA binding site [nucleotide binding] 1173027006441 sequence specific DNA binding site [nucleotide binding]; other site 1173027006442 putative cAMP binding site [chemical binding]; other site 1173027006443 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 1173027006444 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1173027006445 NAD binding site [chemical binding]; other site 1173027006446 homotetramer interface [polypeptide binding]; other site 1173027006447 homodimer interface [polypeptide binding]; other site 1173027006448 substrate binding site [chemical binding]; other site 1173027006449 active site 1173027006450 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 1173027006451 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1173027006452 putative active site pocket [active] 1173027006453 4-fold oligomerization interface [polypeptide binding]; other site 1173027006454 metal binding residues [ion binding]; metal-binding site 1173027006455 3-fold/trimer interface [polypeptide binding]; other site 1173027006456 AAA ATPase domain; Region: AAA_16; pfam13191 1173027006457 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027006458 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027006459 structural tetrad; other site 1173027006460 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027006461 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027006462 structural tetrad; other site 1173027006463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027006464 Coenzyme A binding pocket [chemical binding]; other site 1173027006465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027006466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027006467 non-specific DNA binding site [nucleotide binding]; other site 1173027006468 salt bridge; other site 1173027006469 sequence-specific DNA binding site [nucleotide binding]; other site 1173027006470 Protein of unknown function DUF89; Region: DUF89; pfam01937 1173027006471 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173027006472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027006473 putative active site [active] 1173027006474 putative metal binding site [ion binding]; other site 1173027006475 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027006476 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027006477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027006478 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173027006479 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027006480 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027006481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027006482 Walker A motif; other site 1173027006483 ATP binding site [chemical binding]; other site 1173027006484 Walker B motif; other site 1173027006485 arginine finger; other site 1173027006486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027006487 Walker A motif; other site 1173027006488 ATP binding site [chemical binding]; other site 1173027006489 Walker B motif; other site 1173027006490 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173027006491 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1173027006492 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173027006493 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173027006494 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1173027006495 dihydropteroate synthase; Region: DHPS; TIGR01496 1173027006496 substrate binding pocket [chemical binding]; other site 1173027006497 dimer interface [polypeptide binding]; other site 1173027006498 inhibitor binding site; inhibition site 1173027006499 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1173027006500 triosephosphate isomerase; Provisional; Region: PRK14565 1173027006501 dimer interface [polypeptide binding]; other site 1173027006502 substrate binding site [chemical binding]; other site 1173027006503 catalytic triad [active] 1173027006504 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027006505 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027006506 structural tetrad; other site 1173027006507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027006508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027006509 non-specific DNA binding site [nucleotide binding]; other site 1173027006510 salt bridge; other site 1173027006511 sequence-specific DNA binding site [nucleotide binding]; other site 1173027006512 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173027006513 D-xylulose kinase; Region: XylB; TIGR01312 1173027006514 nucleotide binding site [chemical binding]; other site 1173027006515 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027006516 TrkA-N domain; Region: TrkA_N; pfam02254 1173027006517 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1173027006518 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1173027006519 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 1173027006520 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1173027006521 intersubunit interface [polypeptide binding]; other site 1173027006522 active site 1173027006523 Zn2+ binding site [ion binding]; other site 1173027006524 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173027006525 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027006526 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1173027006527 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1173027006528 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1173027006529 dimer interface [polypeptide binding]; other site 1173027006530 active site 1173027006531 catalytic residue [active] 1173027006532 metal binding site [ion binding]; metal-binding site 1173027006533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006534 PAS domain; Region: PAS_9; pfam13426 1173027006535 putative active site [active] 1173027006536 heme pocket [chemical binding]; other site 1173027006537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027006538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006539 dimer interface [polypeptide binding]; other site 1173027006540 phosphorylation site [posttranslational modification] 1173027006541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006542 ATP binding site [chemical binding]; other site 1173027006543 Mg2+ binding site [ion binding]; other site 1173027006544 G-X-G motif; other site 1173027006545 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027006546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006547 active site 1173027006548 phosphorylation site [posttranslational modification] 1173027006549 intermolecular recognition site; other site 1173027006550 dimerization interface [polypeptide binding]; other site 1173027006551 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006553 active site 1173027006554 phosphorylation site [posttranslational modification] 1173027006555 intermolecular recognition site; other site 1173027006556 dimerization interface [polypeptide binding]; other site 1173027006557 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027006558 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027006559 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006561 putative active site [active] 1173027006562 heme pocket [chemical binding]; other site 1173027006563 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027006564 cyclase homology domain; Region: CHD; cd07302 1173027006565 nucleotidyl binding site; other site 1173027006566 metal binding site [ion binding]; metal-binding site 1173027006567 dimer interface [polypeptide binding]; other site 1173027006568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027006569 non-specific DNA binding site [nucleotide binding]; other site 1173027006570 salt bridge; other site 1173027006571 sequence-specific DNA binding site [nucleotide binding]; other site 1173027006572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027006573 non-specific DNA binding site [nucleotide binding]; other site 1173027006574 salt bridge; other site 1173027006575 sequence-specific DNA binding site [nucleotide binding]; other site 1173027006576 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1173027006577 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027006578 HSP70 interaction site [polypeptide binding]; other site 1173027006579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006580 binding surface 1173027006581 TPR motif; other site 1173027006582 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027006583 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1173027006584 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027006585 putative active site [active] 1173027006586 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1173027006587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173027006588 Walker A motif; other site 1173027006589 ATP binding site [chemical binding]; other site 1173027006590 Walker B motif; other site 1173027006591 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1173027006592 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1173027006593 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1173027006594 Cupin domain; Region: Cupin_2; pfam07883 1173027006595 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1173027006596 active site 1173027006597 putative lithium-binding site [ion binding]; other site 1173027006598 substrate binding site [chemical binding]; other site 1173027006599 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027006600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027006601 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1173027006602 active site 1173027006603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 1173027006604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1173027006605 active site 1173027006606 substrate binding site [chemical binding]; other site 1173027006607 metal binding site [ion binding]; metal-binding site 1173027006608 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173027006609 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1173027006610 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027006611 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173027006612 TM-ABC transporter signature motif; other site 1173027006613 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027006614 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027006615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027006616 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027006617 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027006618 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027006619 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027006620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027006621 Phytochrome region; Region: PHY; pfam00360 1173027006622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006623 dimer interface [polypeptide binding]; other site 1173027006624 phosphorylation site [posttranslational modification] 1173027006625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006626 ATP binding site [chemical binding]; other site 1173027006627 Mg2+ binding site [ion binding]; other site 1173027006628 G-X-G motif; other site 1173027006629 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006631 active site 1173027006632 phosphorylation site [posttranslational modification] 1173027006633 intermolecular recognition site; other site 1173027006634 dimerization interface [polypeptide binding]; other site 1173027006635 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006637 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006638 active site 1173027006639 phosphorylation site [posttranslational modification] 1173027006640 intermolecular recognition site; other site 1173027006641 dimerization interface [polypeptide binding]; other site 1173027006642 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027006643 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173027006644 TM-ABC transporter signature motif; other site 1173027006645 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173027006646 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173027006647 Walker A/P-loop; other site 1173027006648 ATP binding site [chemical binding]; other site 1173027006649 Q-loop/lid; other site 1173027006650 ABC transporter signature motif; other site 1173027006651 Walker B; other site 1173027006652 D-loop; other site 1173027006653 H-loop/switch region; other site 1173027006654 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173027006655 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173027006656 Walker A/P-loop; other site 1173027006657 ATP binding site [chemical binding]; other site 1173027006658 Q-loop/lid; other site 1173027006659 ABC transporter signature motif; other site 1173027006660 Walker B; other site 1173027006661 D-loop; other site 1173027006662 H-loop/switch region; other site 1173027006663 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173027006664 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1173027006665 active site 1173027006666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027006667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027006668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027006669 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173027006670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027006671 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1173027006672 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027006673 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173027006674 protein binding site [polypeptide binding]; other site 1173027006675 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027006676 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027006677 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173027006678 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027006679 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027006680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027006681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006682 binding surface 1173027006683 TPR motif; other site 1173027006684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006685 binding surface 1173027006686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027006687 TPR motif; other site 1173027006688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027006689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027006690 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027006691 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027006692 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1173027006693 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1173027006694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006695 active site 1173027006696 phosphorylation site [posttranslational modification] 1173027006697 intermolecular recognition site; other site 1173027006698 dimerization interface [polypeptide binding]; other site 1173027006699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027006700 Zn2+ binding site [ion binding]; other site 1173027006701 Mg2+ binding site [ion binding]; other site 1173027006702 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1173027006703 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1173027006704 Substrate binding site; other site 1173027006705 Mg++ binding site; other site 1173027006706 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1173027006707 active site 1173027006708 substrate binding site [chemical binding]; other site 1173027006709 CoA binding site [chemical binding]; other site 1173027006710 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1173027006711 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173027006712 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173027006713 active site 1173027006714 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027006715 cyclase homology domain; Region: CHD; cd07302 1173027006716 nucleotidyl binding site; other site 1173027006717 metal binding site [ion binding]; metal-binding site 1173027006718 dimer interface [polypeptide binding]; other site 1173027006719 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027006720 ABC1 family; Region: ABC1; pfam03109 1173027006721 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173027006722 active site 1173027006723 ATP binding site [chemical binding]; other site 1173027006724 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1173027006725 G1 box; other site 1173027006726 GTP/Mg2+ binding site [chemical binding]; other site 1173027006727 G2 box; other site 1173027006728 Switch I region; other site 1173027006729 G3 box; other site 1173027006730 Switch II region; other site 1173027006731 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173027006732 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027006733 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027006734 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173027006735 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1173027006736 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1173027006737 active site 1173027006738 catalytic site [active] 1173027006739 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173027006740 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 1173027006741 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 1173027006742 YceG-like family; Region: YceG; pfam02618 1173027006743 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1173027006744 dimerization interface [polypeptide binding]; other site 1173027006745 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1173027006746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027006747 active site 1173027006748 motif I; other site 1173027006749 motif II; other site 1173027006750 gamma-glutamyl kinase; Provisional; Region: PRK05429 1173027006751 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1173027006752 nucleotide binding site [chemical binding]; other site 1173027006753 homotetrameric interface [polypeptide binding]; other site 1173027006754 putative phosphate binding site [ion binding]; other site 1173027006755 putative allosteric binding site; other site 1173027006756 PUA domain; Region: PUA; pfam01472 1173027006757 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027006758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006759 active site 1173027006760 phosphorylation site [posttranslational modification] 1173027006761 intermolecular recognition site; other site 1173027006762 dimerization interface [polypeptide binding]; other site 1173027006763 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006765 putative active site [active] 1173027006766 heme pocket [chemical binding]; other site 1173027006767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027006768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006769 dimer interface [polypeptide binding]; other site 1173027006770 phosphorylation site [posttranslational modification] 1173027006771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006772 ATP binding site [chemical binding]; other site 1173027006773 Mg2+ binding site [ion binding]; other site 1173027006774 G-X-G motif; other site 1173027006775 enolase; Provisional; Region: eno; PRK00077 1173027006776 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1173027006777 dimer interface [polypeptide binding]; other site 1173027006778 metal binding site [ion binding]; metal-binding site 1173027006779 substrate binding pocket [chemical binding]; other site 1173027006780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027006781 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1173027006782 dimer interface [polypeptide binding]; other site 1173027006783 active site 1173027006784 metal binding site [ion binding]; metal-binding site 1173027006785 glutathione binding site [chemical binding]; other site 1173027006786 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173027006787 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173027006788 short chain dehydrogenase; Provisional; Region: PRK08303 1173027006789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027006790 NAD(P) binding site [chemical binding]; other site 1173027006791 active site 1173027006792 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173027006793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027006794 NAD(P) binding site [chemical binding]; other site 1173027006795 active site 1173027006796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1173027006797 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 1173027006798 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173027006799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027006800 FeS/SAM binding site; other site 1173027006801 TRAM domain; Region: TRAM; pfam01938 1173027006802 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173027006803 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1173027006804 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027006805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027006806 catalytic loop [active] 1173027006807 iron binding site [ion binding]; other site 1173027006808 Staphylococcal nuclease homologues; Region: SNc; smart00318 1173027006809 Catalytic site; other site 1173027006810 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1173027006811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173027006812 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1173027006813 active site 1173027006814 dimerization interface [polypeptide binding]; other site 1173027006815 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027006816 HSP70 interaction site [polypeptide binding]; other site 1173027006817 TPR repeat; Region: TPR_11; pfam13414 1173027006818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027006819 binding surface 1173027006820 TPR motif; other site 1173027006821 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1173027006822 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173027006823 dimer interface [polypeptide binding]; other site 1173027006824 motif 1; other site 1173027006825 active site 1173027006826 motif 2; other site 1173027006827 motif 3; other site 1173027006828 Ferredoxin [Energy production and conversion]; Region: COG1146 1173027006829 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027006830 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027006831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027006832 active site 1173027006833 ATP binding site [chemical binding]; other site 1173027006834 substrate binding site [chemical binding]; other site 1173027006835 activation loop (A-loop); other site 1173027006836 GUN4-like; Region: GUN4; pfam05419 1173027006837 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1173027006838 dimer interface [polypeptide binding]; other site 1173027006839 motif 1; other site 1173027006840 active site 1173027006841 motif 2; other site 1173027006842 motif 3; other site 1173027006843 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173027006844 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1173027006845 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1173027006846 Competence protein; Region: Competence; pfam03772 1173027006847 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1173027006848 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027006849 GAF domain; Region: GAF; pfam01590 1173027006850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027006851 Zn2+ binding site [ion binding]; other site 1173027006852 Mg2+ binding site [ion binding]; other site 1173027006853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027006854 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 1173027006855 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1173027006856 putative active site [active] 1173027006857 catalytic residue [active] 1173027006858 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1173027006859 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173027006860 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027006861 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173027006862 Acylphosphatase; Region: Acylphosphatase; cl00551 1173027006863 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173027006864 Acylphosphatase; Region: Acylphosphatase; cl00551 1173027006865 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173027006866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027006867 G1 box; other site 1173027006868 GTP/Mg2+ binding site [chemical binding]; other site 1173027006869 G2 box; other site 1173027006870 Switch I region; other site 1173027006871 G3 box; other site 1173027006872 Switch II region; other site 1173027006873 G4 box; other site 1173027006874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006875 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027006876 putative active site [active] 1173027006877 heme pocket [chemical binding]; other site 1173027006878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006879 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027006880 putative active site [active] 1173027006881 heme pocket [chemical binding]; other site 1173027006882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006883 putative active site [active] 1173027006884 heme pocket [chemical binding]; other site 1173027006885 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006886 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027006887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006888 dimer interface [polypeptide binding]; other site 1173027006889 phosphorylation site [posttranslational modification] 1173027006890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006891 ATP binding site [chemical binding]; other site 1173027006892 Mg2+ binding site [ion binding]; other site 1173027006893 G-X-G motif; other site 1173027006894 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006896 active site 1173027006897 phosphorylation site [posttranslational modification] 1173027006898 intermolecular recognition site; other site 1173027006899 dimerization interface [polypeptide binding]; other site 1173027006900 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006902 putative active site [active] 1173027006903 heme pocket [chemical binding]; other site 1173027006904 PAS domain S-box; Region: sensory_box; TIGR00229 1173027006905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006906 putative active site [active] 1173027006907 heme pocket [chemical binding]; other site 1173027006908 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027006909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006910 active site 1173027006911 phosphorylation site [posttranslational modification] 1173027006912 intermolecular recognition site; other site 1173027006913 dimerization interface [polypeptide binding]; other site 1173027006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027006916 active site 1173027006917 phosphorylation site [posttranslational modification] 1173027006918 intermolecular recognition site; other site 1173027006919 dimerization interface [polypeptide binding]; other site 1173027006920 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006922 active site 1173027006923 phosphorylation site [posttranslational modification] 1173027006924 intermolecular recognition site; other site 1173027006925 dimerization interface [polypeptide binding]; other site 1173027006926 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027006927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027006928 putative active site [active] 1173027006929 heme pocket [chemical binding]; other site 1173027006930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027006931 dimer interface [polypeptide binding]; other site 1173027006932 phosphorylation site [posttranslational modification] 1173027006933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027006934 ATP binding site [chemical binding]; other site 1173027006935 Mg2+ binding site [ion binding]; other site 1173027006936 G-X-G motif; other site 1173027006937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027006938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006939 active site 1173027006940 phosphorylation site [posttranslational modification] 1173027006941 intermolecular recognition site; other site 1173027006942 dimerization interface [polypeptide binding]; other site 1173027006943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027006944 DNA binding site [nucleotide binding] 1173027006945 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027006946 putative binding surface; other site 1173027006947 active site 1173027006948 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006950 active site 1173027006951 phosphorylation site [posttranslational modification] 1173027006952 intermolecular recognition site; other site 1173027006953 dimerization interface [polypeptide binding]; other site 1173027006954 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027006955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027006956 active site 1173027006957 phosphorylation site [posttranslational modification] 1173027006958 intermolecular recognition site; other site 1173027006959 dimerization interface [polypeptide binding]; other site 1173027006960 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1173027006961 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1173027006962 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 1173027006963 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1173027006964 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173027006965 active site 1173027006966 catalytic triad [active] 1173027006967 oxyanion hole [active] 1173027006968 S-layer homology domain; Region: SLH; pfam00395 1173027006969 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173027006970 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173027006971 Catalytic site [active] 1173027006972 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173027006973 active site 1173027006974 dimer interface [polypeptide binding]; other site 1173027006975 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1173027006976 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1173027006977 active site 1173027006978 HIGH motif; other site 1173027006979 dimer interface [polypeptide binding]; other site 1173027006980 KMSKS motif; other site 1173027006981 Transglycosylase; Region: Transgly; pfam00912 1173027006982 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173027006983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173027006984 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 1173027006985 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1173027006986 Short C-terminal domain; Region: SHOCT; pfam09851 1173027006987 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1173027006988 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027006989 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027006990 active site 1173027006991 ATP binding site [chemical binding]; other site 1173027006992 substrate binding site [chemical binding]; other site 1173027006993 GUN4-like; Region: GUN4; pfam05419 1173027006994 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027006995 putative active site [active] 1173027006996 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1173027006997 oligomerization interface [polypeptide binding]; other site 1173027006998 active site 1173027006999 metal binding site [ion binding]; metal-binding site 1173027007000 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1173027007001 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1173027007002 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1173027007003 homodimer interface [polypeptide binding]; other site 1173027007004 active site 1173027007005 heterodimer interface [polypeptide binding]; other site 1173027007006 catalytic residue [active] 1173027007007 metal binding site [ion binding]; metal-binding site 1173027007008 RbcX protein; Region: RcbX; pfam02341 1173027007009 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1173027007010 multimerization interface [polypeptide binding]; other site 1173027007011 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173027007012 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1173027007013 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1173027007014 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 1173027007015 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173027007016 putative multimerization interface [polypeptide binding]; other site 1173027007017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027007018 non-specific DNA binding site [nucleotide binding]; other site 1173027007019 salt bridge; other site 1173027007020 sequence-specific DNA binding site [nucleotide binding]; other site 1173027007021 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1173027007022 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173027007023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027007024 Walker A motif; other site 1173027007025 ATP binding site [chemical binding]; other site 1173027007026 Walker B motif; other site 1173027007027 arginine finger; other site 1173027007028 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027007029 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027007030 putative active site [active] 1173027007031 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1173027007032 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1173027007033 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027007034 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007035 active site 1173027007036 ATP binding site [chemical binding]; other site 1173027007037 substrate binding site [chemical binding]; other site 1173027007038 activation loop (A-loop); other site 1173027007039 TPR repeat; Region: TPR_11; pfam13414 1173027007040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007041 binding surface 1173027007042 TPR motif; other site 1173027007043 TPR repeat; Region: TPR_11; pfam13414 1173027007044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007045 binding surface 1173027007046 TPR motif; other site 1173027007047 TPR repeat; Region: TPR_11; pfam13414 1173027007048 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027007049 HSP70 interaction site [polypeptide binding]; other site 1173027007050 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173027007051 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 1173027007052 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1173027007053 tetramer interface [polypeptide binding]; other site 1173027007054 TPP-binding site [chemical binding]; other site 1173027007055 heterodimer interface [polypeptide binding]; other site 1173027007056 phosphorylation loop region [posttranslational modification] 1173027007057 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 1173027007058 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 1173027007059 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1173027007060 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1173027007061 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007062 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027007063 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027007064 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007065 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173027007066 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007067 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007069 binding surface 1173027007070 TPR motif; other site 1173027007071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007073 binding surface 1173027007074 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007075 TPR motif; other site 1173027007076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007077 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007079 binding surface 1173027007080 TPR motif; other site 1173027007081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007083 CHAT domain; Region: CHAT; pfam12770 1173027007084 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027007085 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007092 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007093 arogenate dehydrogenase; Reviewed; Region: PRK07417 1173027007094 prephenate dehydrogenase; Validated; Region: PRK08507 1173027007095 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173027007096 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027007097 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173027007098 protein binding site [polypeptide binding]; other site 1173027007099 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1173027007100 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1173027007101 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 1173027007102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027007103 FeS/SAM binding site; other site 1173027007104 Arv1-like family; Region: Arv1; pfam04161 1173027007105 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1173027007106 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173027007107 nucleotide binding site [chemical binding]; other site 1173027007108 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173027007109 SBD interface [polypeptide binding]; other site 1173027007110 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027007111 TrkA-N domain; Region: TrkA_N; pfam02254 1173027007112 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1173027007113 TrkA-N domain; Region: TrkA_N; pfam02254 1173027007114 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1173027007115 homotrimer interaction site [polypeptide binding]; other site 1173027007116 putative active site [active] 1173027007117 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1173027007118 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173027007119 acyl-activating enzyme (AAE) consensus motif; other site 1173027007120 AMP binding site [chemical binding]; other site 1173027007121 active site 1173027007122 CoA binding site [chemical binding]; other site 1173027007123 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1173027007124 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1173027007125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027007126 Condensation domain; Region: Condensation; pfam00668 1173027007127 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173027007128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173027007129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027007130 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173027007131 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1173027007132 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1173027007133 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007134 putative active site [active] 1173027007135 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007136 putative active site [active] 1173027007137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027007138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027007139 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173027007140 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1173027007141 active site 1173027007142 catalytic site [active] 1173027007143 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1173027007144 AAA ATPase domain; Region: AAA_16; pfam13191 1173027007145 NACHT domain; Region: NACHT; pfam05729 1173027007146 NolX protein; Region: NolX; pfam05819 1173027007147 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173027007148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027007149 active site 1173027007150 motif I; other site 1173027007151 motif II; other site 1173027007152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027007153 motif II; other site 1173027007154 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173027007155 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1173027007156 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173027007157 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173027007158 dimerization interface [polypeptide binding]; other site 1173027007159 DPS ferroxidase diiron center [ion binding]; other site 1173027007160 ion pore; other site 1173027007161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027007162 sequence-specific DNA binding site [nucleotide binding]; other site 1173027007163 salt bridge; other site 1173027007164 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1173027007165 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173027007166 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173027007167 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173027007168 dimerization interface [polypeptide binding]; other site 1173027007169 DPS ferroxidase diiron center [ion binding]; other site 1173027007170 ion pore; other site 1173027007171 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1173027007172 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027007173 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173027007174 RNB domain; Region: RNB; pfam00773 1173027007175 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1173027007176 ribosomal protein L33; Region: rpl33; CHL00104 1173027007177 RDD family; Region: RDD; pfam06271 1173027007178 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1173027007179 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1173027007180 dimer interface [polypeptide binding]; other site 1173027007181 putative functional site; other site 1173027007182 putative MPT binding site; other site 1173027007183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027007184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007185 active site 1173027007186 ATP binding site [chemical binding]; other site 1173027007187 substrate binding site [chemical binding]; other site 1173027007188 activation loop (A-loop); other site 1173027007189 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027007190 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007191 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007192 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1173027007193 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1173027007194 putative tRNA-binding site [nucleotide binding]; other site 1173027007195 B3/4 domain; Region: B3_4; pfam03483 1173027007196 tRNA synthetase B5 domain; Region: B5; smart00874 1173027007197 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1173027007198 dimer interface [polypeptide binding]; other site 1173027007199 motif 1; other site 1173027007200 motif 3; other site 1173027007201 motif 2; other site 1173027007202 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1173027007203 YciI-like protein; Reviewed; Region: PRK12864 1173027007204 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027007205 CHASE2 domain; Region: CHASE2; pfam05226 1173027007206 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027007207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007208 active site 1173027007209 ATP binding site [chemical binding]; other site 1173027007210 substrate binding site [chemical binding]; other site 1173027007211 activation loop (A-loop); other site 1173027007212 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027007213 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027007214 active site 1173027007215 ATP binding site [chemical binding]; other site 1173027007216 TPR repeat; Region: TPR_11; pfam13414 1173027007217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007218 binding surface 1173027007219 TPR motif; other site 1173027007220 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027007221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007222 binding surface 1173027007223 TPR motif; other site 1173027007224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007225 binding surface 1173027007226 TPR motif; other site 1173027007227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007228 binding surface 1173027007229 TPR repeat; Region: TPR_11; pfam13414 1173027007230 TPR motif; other site 1173027007231 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027007232 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173027007233 active site 1173027007234 SAM binding site [chemical binding]; other site 1173027007235 homodimer interface [polypeptide binding]; other site 1173027007236 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173027007237 putative active site [active] 1173027007238 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173027007239 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173027007240 putative active site [active] 1173027007241 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173027007242 putative active site [active] 1173027007243 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1173027007244 Ferritin-like domain; Region: Ferritin; pfam00210 1173027007245 dimanganese center [ion binding]; other site 1173027007246 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027007247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007248 active site 1173027007249 ATP binding site [chemical binding]; other site 1173027007250 substrate binding site [chemical binding]; other site 1173027007251 activation loop (A-loop); other site 1173027007252 GUN4-like; Region: GUN4; pfam05419 1173027007253 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1173027007254 PAS domain S-box; Region: sensory_box; TIGR00229 1173027007255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007256 putative active site [active] 1173027007257 heme pocket [chemical binding]; other site 1173027007258 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007259 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007260 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007261 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007262 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007263 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027007265 dimer interface [polypeptide binding]; other site 1173027007266 phosphorylation site [posttranslational modification] 1173027007267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007268 ATP binding site [chemical binding]; other site 1173027007269 Mg2+ binding site [ion binding]; other site 1173027007270 G-X-G motif; other site 1173027007271 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1173027007272 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173027007273 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027007274 amidase; Provisional; Region: PRK09201 1173027007275 Amidase; Region: Amidase; cl11426 1173027007276 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027007277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007278 active site 1173027007279 phosphorylation site [posttranslational modification] 1173027007280 intermolecular recognition site; other site 1173027007281 dimerization interface [polypeptide binding]; other site 1173027007282 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1173027007283 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1173027007284 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027007285 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027007286 cofactor binding site; other site 1173027007287 DNA binding site [nucleotide binding] 1173027007288 substrate interaction site [chemical binding]; other site 1173027007289 hypothetical protein; Provisional; Region: PRK06208 1173027007290 intersubunit interface [polypeptide binding]; other site 1173027007291 active site 1173027007292 Zn2+ binding site [ion binding]; other site 1173027007293 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1173027007294 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173027007295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007296 PAS fold; Region: PAS_3; pfam08447 1173027007297 putative active site [active] 1173027007298 heme pocket [chemical binding]; other site 1173027007299 PAS domain S-box; Region: sensory_box; TIGR00229 1173027007300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007301 putative active site [active] 1173027007302 heme pocket [chemical binding]; other site 1173027007303 GAF domain; Region: GAF_3; pfam13492 1173027007304 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007305 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007308 dimer interface [polypeptide binding]; other site 1173027007309 phosphorylation site [posttranslational modification] 1173027007310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007311 ATP binding site [chemical binding]; other site 1173027007312 Mg2+ binding site [ion binding]; other site 1173027007313 G-X-G motif; other site 1173027007314 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027007315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007316 active site 1173027007317 phosphorylation site [posttranslational modification] 1173027007318 intermolecular recognition site; other site 1173027007319 dimerization interface [polypeptide binding]; other site 1173027007320 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027007321 putative binding surface; other site 1173027007322 active site 1173027007323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007324 active site 1173027007325 phosphorylation site [posttranslational modification] 1173027007326 intermolecular recognition site; other site 1173027007327 dimerization interface [polypeptide binding]; other site 1173027007328 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007329 GAF domain; Region: GAF; pfam01590 1173027007330 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173027007331 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1173027007332 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027007333 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173027007334 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027007335 Walker A/P-loop; other site 1173027007336 ATP binding site [chemical binding]; other site 1173027007337 Q-loop/lid; other site 1173027007338 ABC transporter signature motif; other site 1173027007339 Walker B; other site 1173027007340 D-loop; other site 1173027007341 H-loop/switch region; other site 1173027007342 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027007343 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 1173027007344 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173027007345 Predicted membrane protein [Function unknown]; Region: COG4244 1173027007346 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173027007347 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1173027007348 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173027007349 Hemerythrin-like domain; Region: Hr-like; cd12108 1173027007350 Rhomboid family; Region: Rhomboid; pfam01694 1173027007351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007352 PAS fold; Region: PAS_3; pfam08447 1173027007353 putative active site [active] 1173027007354 heme pocket [chemical binding]; other site 1173027007355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007356 PAS fold; Region: PAS_3; pfam08447 1173027007357 putative active site [active] 1173027007358 heme pocket [chemical binding]; other site 1173027007359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007360 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027007361 putative active site [active] 1173027007362 heme pocket [chemical binding]; other site 1173027007363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007364 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027007365 putative active site [active] 1173027007366 heme pocket [chemical binding]; other site 1173027007367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007368 putative active site [active] 1173027007369 heme pocket [chemical binding]; other site 1173027007370 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027007371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007372 putative active site [active] 1173027007373 heme pocket [chemical binding]; other site 1173027007374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007375 dimer interface [polypeptide binding]; other site 1173027007376 phosphorylation site [posttranslational modification] 1173027007377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007378 ATP binding site [chemical binding]; other site 1173027007379 Mg2+ binding site [ion binding]; other site 1173027007380 G-X-G motif; other site 1173027007381 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1173027007382 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1173027007383 Protein of unknown function DUF82; Region: DUF82; pfam01927 1173027007384 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173027007385 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1173027007386 CP12 domain; Region: CP12; pfam02672 1173027007387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1173027007388 FIST N domain; Region: FIST; pfam08495 1173027007389 FIST C domain; Region: FIST_C; pfam10442 1173027007390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027007391 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027007392 active site 1173027007393 metal binding site [ion binding]; metal-binding site 1173027007394 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1173027007395 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027007396 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007397 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007398 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 1173027007399 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173027007400 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173027007401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007402 active site 1173027007403 phosphorylation site [posttranslational modification] 1173027007404 intermolecular recognition site; other site 1173027007405 dimerization interface [polypeptide binding]; other site 1173027007406 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027007407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007408 putative active site [active] 1173027007409 heme pocket [chemical binding]; other site 1173027007410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007411 putative active site [active] 1173027007412 heme pocket [chemical binding]; other site 1173027007413 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007414 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007415 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007418 dimer interface [polypeptide binding]; other site 1173027007419 phosphorylation site [posttranslational modification] 1173027007420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007421 Mg2+ binding site [ion binding]; other site 1173027007422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007424 ATP binding site [chemical binding]; other site 1173027007425 G-X-G motif; other site 1173027007426 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027007427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007428 active site 1173027007429 phosphorylation site [posttranslational modification] 1173027007430 intermolecular recognition site; other site 1173027007431 dimerization interface [polypeptide binding]; other site 1173027007432 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173027007433 PAS domain S-box; Region: sensory_box; TIGR00229 1173027007434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007435 putative active site [active] 1173027007436 heme pocket [chemical binding]; other site 1173027007437 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007438 GAF domain; Region: GAF; pfam01590 1173027007439 PAS domain; Region: PAS; smart00091 1173027007440 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027007441 putative active site [active] 1173027007442 heme pocket [chemical binding]; other site 1173027007443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007444 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027007445 putative active site [active] 1173027007446 heme pocket [chemical binding]; other site 1173027007447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007448 putative active site [active] 1173027007449 heme pocket [chemical binding]; other site 1173027007450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007451 dimer interface [polypeptide binding]; other site 1173027007452 phosphorylation site [posttranslational modification] 1173027007453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007454 ATP binding site [chemical binding]; other site 1173027007455 Mg2+ binding site [ion binding]; other site 1173027007456 G-X-G motif; other site 1173027007457 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1173027007458 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173027007459 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173027007460 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173027007461 metal ion-dependent adhesion site (MIDAS); other site 1173027007462 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1173027007463 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1173027007464 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027007465 substrate binding site [chemical binding]; other site 1173027007466 activation loop (A-loop); other site 1173027007467 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027007468 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027007469 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173027007470 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173027007471 FecR protein; Region: FecR; pfam04773 1173027007472 HPP family; Region: HPP; pfam04982 1173027007473 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1173027007474 active site clefts [active] 1173027007475 zinc binding site [ion binding]; other site 1173027007476 dimer interface [polypeptide binding]; other site 1173027007477 FAD binding domain; Region: FAD_binding_4; pfam01565 1173027007478 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1173027007479 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1173027007480 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 1173027007481 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 1173027007482 TIGR02588 family protein; Region: TIGR02588 1173027007483 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173027007484 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173027007485 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 1173027007486 ResB-like family; Region: ResB; pfam05140 1173027007487 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1173027007488 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173027007489 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027007490 glyceraldehyde-3-phosphate dehydrogenase B; Region: PLN02237 1173027007491 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027007492 AAA ATPase domain; Region: AAA_16; pfam13191 1173027007493 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1173027007494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007495 binding surface 1173027007496 TPR motif; other site 1173027007497 TPR repeat; Region: TPR_11; pfam13414 1173027007498 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027007499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007500 binding surface 1173027007501 TPR motif; other site 1173027007502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007503 binding surface 1173027007504 TPR motif; other site 1173027007505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007506 binding surface 1173027007507 TPR motif; other site 1173027007508 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1173027007509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007510 putative active site [active] 1173027007511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007513 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007514 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007515 hypothetical protein; Validated; Region: PRK07198 1173027007516 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1173027007517 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1173027007518 dimerization interface [polypeptide binding]; other site 1173027007519 active site 1173027007520 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1173027007521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027007522 active site 1173027007523 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 1173027007524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173027007525 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1173027007526 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173027007527 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1173027007528 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1173027007529 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1173027007530 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1173027007531 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173027007532 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1173027007533 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1173027007534 conserved cys residue [active] 1173027007535 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 1173027007536 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1173027007537 dimerization interface [polypeptide binding]; other site 1173027007538 active site 1173027007539 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173027007540 Predicted membrane protein [Function unknown]; Region: COG1950 1173027007541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027007542 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173027007543 NAD(P) binding site [chemical binding]; other site 1173027007544 active site 1173027007545 short chain dehydrogenase; Provisional; Region: PRK06701 1173027007546 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1173027007547 NAD binding site [chemical binding]; other site 1173027007548 metal binding site [ion binding]; metal-binding site 1173027007549 active site 1173027007550 Transthyretin-like family; Region: DUF290; pfam01060 1173027007551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027007552 dimerization interface [polypeptide binding]; other site 1173027007553 putative DNA binding site [nucleotide binding]; other site 1173027007554 putative Zn2+ binding site [ion binding]; other site 1173027007555 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173027007556 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173027007557 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173027007558 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173027007559 interchain domain interface [polypeptide binding]; other site 1173027007560 heme bL binding site [chemical binding]; other site 1173027007561 intrachain domain interface; other site 1173027007562 Qo binding site; other site 1173027007563 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1173027007564 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1173027007565 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173027007566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007567 dimer interface [polypeptide binding]; other site 1173027007568 phosphorylation site [posttranslational modification] 1173027007569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007570 ATP binding site [chemical binding]; other site 1173027007571 Mg2+ binding site [ion binding]; other site 1173027007572 G-X-G motif; other site 1173027007573 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1173027007574 non-specific DNA binding site [nucleotide binding]; other site 1173027007575 salt bridge; other site 1173027007576 sequence-specific DNA binding site [nucleotide binding]; other site 1173027007577 multidrug efflux protein; Reviewed; Region: PRK01766 1173027007578 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173027007579 cation binding site [ion binding]; other site 1173027007580 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007581 putative active site [active] 1173027007582 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173027007583 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1173027007584 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173027007585 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173027007586 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1173027007587 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027007588 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007589 active site 1173027007590 ATP binding site [chemical binding]; other site 1173027007591 substrate binding site [chemical binding]; other site 1173027007592 activation loop (A-loop); other site 1173027007593 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1173027007594 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1173027007595 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007596 active site 1173027007597 ATP binding site [chemical binding]; other site 1173027007598 substrate binding site [chemical binding]; other site 1173027007599 activation loop (A-loop); other site 1173027007600 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173027007601 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1173027007602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027007603 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027007604 active site 1173027007605 metal binding site [ion binding]; metal-binding site 1173027007606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027007607 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 1173027007608 Walker A motif; other site 1173027007609 ATP binding site [chemical binding]; other site 1173027007610 Walker B motif; other site 1173027007611 arginine finger; other site 1173027007612 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1173027007613 metal ion-dependent adhesion site (MIDAS); other site 1173027007614 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1173027007615 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173027007616 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173027007617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027007618 dimer interface [polypeptide binding]; other site 1173027007619 conserved gate region; other site 1173027007620 putative PBP binding loops; other site 1173027007621 ABC-ATPase subunit interface; other site 1173027007622 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027007623 NMT1-like family; Region: NMT1_2; pfam13379 1173027007624 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027007625 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173027007626 Walker A/P-loop; other site 1173027007627 ATP binding site [chemical binding]; other site 1173027007628 Q-loop/lid; other site 1173027007629 ABC transporter signature motif; other site 1173027007630 Walker B; other site 1173027007631 D-loop; other site 1173027007632 H-loop/switch region; other site 1173027007633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173027007634 sequence-specific DNA binding site [nucleotide binding]; other site 1173027007635 salt bridge; other site 1173027007636 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007637 putative active site [active] 1173027007638 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 1173027007639 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1173027007640 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 1173027007641 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1173027007642 P-loop; other site 1173027007643 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007644 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027007645 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007646 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007647 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007648 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007649 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007651 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1173027007652 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1173027007653 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173027007654 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173027007655 putative trimer interface [polypeptide binding]; other site 1173027007656 putative CoA binding site [chemical binding]; other site 1173027007657 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027007658 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173027007659 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027007660 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173027007661 [2Fe-2S] cluster binding site [ion binding]; other site 1173027007662 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027007663 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027007664 catalytic loop [active] 1173027007665 iron binding site [ion binding]; other site 1173027007666 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1173027007667 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173027007668 dinuclear metal binding motif [ion binding]; other site 1173027007669 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027007670 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173027007671 [2Fe-2S] cluster binding site [ion binding]; other site 1173027007672 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1173027007673 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173027007674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027007675 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173027007676 DXD motif; other site 1173027007677 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1173027007678 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1173027007679 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1173027007680 active site 1173027007681 putative substrate binding pocket [chemical binding]; other site 1173027007682 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173027007683 Protein of unknown function (DUF962); Region: DUF962; cl01879 1173027007684 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027007685 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173027007686 [2Fe-2S] cluster binding site [ion binding]; other site 1173027007687 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 1173027007688 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007691 ATP binding site [chemical binding]; other site 1173027007692 Mg2+ binding site [ion binding]; other site 1173027007693 G-X-G motif; other site 1173027007694 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027007695 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173027007696 protein binding surface [polypeptide binding]; other site 1173027007697 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 1173027007698 protein binding surface [polypeptide binding]; other site 1173027007699 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007700 putative active site [active] 1173027007701 AAA ATPase domain; Region: AAA_16; pfam13191 1173027007702 AAA domain; Region: AAA_22; pfam13401 1173027007703 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007704 putative active site [active] 1173027007705 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1173027007706 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173027007707 RNA binding surface [nucleotide binding]; other site 1173027007708 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173027007709 active site 1173027007710 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027007711 CpeS-like protein; Region: CpeS; pfam09367 1173027007712 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027007713 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 1173027007714 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027007715 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027007716 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027007717 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027007718 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027007719 HEAT repeats; Region: HEAT_2; pfam13646 1173027007720 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027007721 HEAT repeats; Region: HEAT_2; pfam13646 1173027007722 HEAT repeats; Region: HEAT_2; pfam13646 1173027007723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007724 binding surface 1173027007725 TPR motif; other site 1173027007726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007727 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027007729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007730 GAF domain; Region: GAF; pfam01590 1173027007731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007733 dimer interface [polypeptide binding]; other site 1173027007734 phosphorylation site [posttranslational modification] 1173027007735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007736 ATP binding site [chemical binding]; other site 1173027007737 Mg2+ binding site [ion binding]; other site 1173027007738 G-X-G motif; other site 1173027007739 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027007740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007741 active site 1173027007742 phosphorylation site [posttranslational modification] 1173027007743 intermolecular recognition site; other site 1173027007744 dimerization interface [polypeptide binding]; other site 1173027007745 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007746 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027007747 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027007748 CHASE2 domain; Region: CHASE2; pfam05226 1173027007749 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027007750 cyclase homology domain; Region: CHD; cd07302 1173027007751 nucleotidyl binding site; other site 1173027007752 metal binding site [ion binding]; metal-binding site 1173027007753 dimer interface [polypeptide binding]; other site 1173027007754 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027007755 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1173027007756 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1173027007757 ATP binding site [chemical binding]; other site 1173027007758 Mg++ binding site [ion binding]; other site 1173027007759 motif III; other site 1173027007760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027007761 nucleotide binding region [chemical binding]; other site 1173027007762 ATP-binding site [chemical binding]; other site 1173027007763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027007764 non-specific DNA binding site [nucleotide binding]; other site 1173027007765 salt bridge; other site 1173027007766 sequence-specific DNA binding site [nucleotide binding]; other site 1173027007767 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1173027007768 active site 1173027007769 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173027007770 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1173027007771 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173027007772 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027007773 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027007774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007775 binding surface 1173027007776 TPR motif; other site 1173027007777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027007779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027007780 binding surface 1173027007781 TPR motif; other site 1173027007782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027007783 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173027007784 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 1173027007785 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173027007786 B12 binding site [chemical binding]; other site 1173027007787 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173027007788 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173027007789 SPRY domain; Region: SPRY; cl02614 1173027007790 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027007791 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027007792 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027007793 CHASE2 domain; Region: CHASE2; pfam05226 1173027007794 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027007795 cyclase homology domain; Region: CHD; cd07302 1173027007796 nucleotidyl binding site; other site 1173027007797 metal binding site [ion binding]; metal-binding site 1173027007798 dimer interface [polypeptide binding]; other site 1173027007799 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027007800 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740 1173027007801 WYL domain; Region: WYL; cl14852 1173027007802 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1173027007803 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 1173027007804 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1173027007805 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1173027007806 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027007807 putative active site [active] 1173027007808 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 1173027007809 CRISPR-associated protein; Region: TIGR03986 1173027007810 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1173027007811 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1173027007812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027007813 S-adenosylmethionine binding site [chemical binding]; other site 1173027007814 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1173027007815 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1173027007816 ligand binding site [chemical binding]; other site 1173027007817 NAD binding site [chemical binding]; other site 1173027007818 dimerization interface [polypeptide binding]; other site 1173027007819 catalytic site [active] 1173027007820 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1173027007821 putative L-serine binding site [chemical binding]; other site 1173027007822 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 1173027007823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173027007824 RNA binding surface [nucleotide binding]; other site 1173027007825 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027007826 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007827 active site 1173027007828 ATP binding site [chemical binding]; other site 1173027007829 substrate binding site [chemical binding]; other site 1173027007830 activation loop (A-loop); other site 1173027007831 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173027007832 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1173027007833 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007835 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027007836 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007838 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007840 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007841 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027007842 pyruvate kinase; Provisional; Region: PRK06354 1173027007843 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173027007844 domain interfaces; other site 1173027007845 active site 1173027007846 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1173027007847 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027007848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027007849 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1173027007850 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1173027007851 folate binding site [chemical binding]; other site 1173027007852 NADP+ binding site [chemical binding]; other site 1173027007853 Urea transporter; Region: UT; pfam03253 1173027007854 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173027007855 EF-hand domain pair; Region: EF_hand_5; pfam13499 1173027007856 Ca2+ binding site [ion binding]; other site 1173027007857 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173027007858 EF-hand domain pair; Region: EF_hand_5; pfam13499 1173027007859 Ca2+ binding site [ion binding]; other site 1173027007860 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1173027007861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027007862 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027007863 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027007864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027007865 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1173027007866 Walker A/P-loop; other site 1173027007867 ATP binding site [chemical binding]; other site 1173027007868 Q-loop/lid; other site 1173027007869 ABC transporter signature motif; other site 1173027007870 Walker B; other site 1173027007871 D-loop; other site 1173027007872 H-loop/switch region; other site 1173027007873 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1173027007874 short chain dehydrogenase; Provisional; Region: PRK06181 1173027007875 NADP binding site [chemical binding]; other site 1173027007876 homodimer interface [polypeptide binding]; other site 1173027007877 substrate binding site [chemical binding]; other site 1173027007878 active site 1173027007879 Peptidase family C69; Region: Peptidase_C69; cl17793 1173027007880 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173027007881 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1173027007882 NADP binding site [chemical binding]; other site 1173027007883 homodimer interface [polypeptide binding]; other site 1173027007884 active site 1173027007885 substrate binding site [chemical binding]; other site 1173027007886 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027007887 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1173027007888 XisH protein; Region: XisH; pfam08814 1173027007889 XisI protein; Region: XisI; pfam08869 1173027007890 XisH protein; Region: XisH; pfam08814 1173027007891 XisI protein; Region: XisI; pfam08869 1173027007892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027007893 NACHT domain; Region: NACHT; pfam05729 1173027007894 Walker A motif; other site 1173027007895 ATP binding site [chemical binding]; other site 1173027007896 Walker B motif; other site 1173027007897 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1173027007898 phytoene desaturase; Region: crtI_fam; TIGR02734 1173027007899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027007900 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 1173027007901 L-aspartate oxidase; Provisional; Region: PRK06175 1173027007902 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173027007903 topology modulation protein; Reviewed; Region: PRK08118 1173027007904 AAA domain; Region: AAA_17; pfam13207 1173027007905 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027007906 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173027007907 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027007908 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027007909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007910 active site 1173027007911 phosphorylation site [posttranslational modification] 1173027007912 intermolecular recognition site; other site 1173027007913 dimerization interface [polypeptide binding]; other site 1173027007914 PAS domain S-box; Region: sensory_box; TIGR00229 1173027007915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007916 putative active site [active] 1173027007917 heme pocket [chemical binding]; other site 1173027007918 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027007919 cyclase homology domain; Region: CHD; cd07302 1173027007920 nucleotidyl binding site; other site 1173027007921 metal binding site [ion binding]; metal-binding site 1173027007922 dimer interface [polypeptide binding]; other site 1173027007923 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027007924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007925 active site 1173027007926 phosphorylation site [posttranslational modification] 1173027007927 intermolecular recognition site; other site 1173027007928 dimerization interface [polypeptide binding]; other site 1173027007929 Protein kinase domain; Region: Pkinase; pfam00069 1173027007930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027007931 active site 1173027007932 ATP binding site [chemical binding]; other site 1173027007933 substrate binding site [chemical binding]; other site 1173027007934 activation loop (A-loop); other site 1173027007935 AAA ATPase domain; Region: AAA_16; pfam13191 1173027007936 Predicted ATPase [General function prediction only]; Region: COG3899 1173027007937 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027007938 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027007939 PAS domain S-box; Region: sensory_box; TIGR00229 1173027007940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027007941 putative active site [active] 1173027007942 heme pocket [chemical binding]; other site 1173027007943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007944 dimer interface [polypeptide binding]; other site 1173027007945 phosphorylation site [posttranslational modification] 1173027007946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007948 ATP binding site [chemical binding]; other site 1173027007949 Mg2+ binding site [ion binding]; other site 1173027007950 G-X-G motif; other site 1173027007951 Peptidase family M48; Region: Peptidase_M48; cl12018 1173027007952 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027007953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027007954 S-adenosylmethionine binding site [chemical binding]; other site 1173027007955 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 1173027007956 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027007957 Leucine rich repeat; Region: LRR_8; pfam13855 1173027007958 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 1173027007959 Leucine rich repeat; Region: LRR_8; pfam13855 1173027007960 Leucine rich repeat; Region: LRR_8; pfam13855 1173027007961 Leucine rich repeat; Region: LRR_8; pfam13855 1173027007962 Proline dehydrogenase; Region: Pro_dh; pfam01619 1173027007963 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1173027007964 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 1173027007965 Glutamate binding site [chemical binding]; other site 1173027007966 homodimer interface [polypeptide binding]; other site 1173027007967 NAD binding site [chemical binding]; other site 1173027007968 catalytic residues [active] 1173027007969 Family description; Region: VCBS; pfam13517 1173027007970 Family description; Region: VCBS; pfam13517 1173027007971 Family description; Region: VCBS; pfam13517 1173027007972 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1173027007973 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173027007974 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173027007975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027007976 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173027007977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027007978 motif II; other site 1173027007979 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173027007980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027007981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027007982 active site 1173027007983 phosphorylation site [posttranslational modification] 1173027007984 intermolecular recognition site; other site 1173027007985 dimerization interface [polypeptide binding]; other site 1173027007986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027007987 DNA binding site [nucleotide binding] 1173027007988 Cupin domain; Region: Cupin_2; cl17218 1173027007989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027007990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027007991 dimer interface [polypeptide binding]; other site 1173027007992 phosphorylation site [posttranslational modification] 1173027007993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027007994 ATP binding site [chemical binding]; other site 1173027007995 Mg2+ binding site [ion binding]; other site 1173027007996 G-X-G motif; other site 1173027007997 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173027007998 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027007999 putative catalytic residue [active] 1173027008000 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173027008001 metal coordination site [ion binding]; other site 1173027008002 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173027008003 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027008004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027008005 dimerization interface [polypeptide binding]; other site 1173027008006 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027008007 cyclase homology domain; Region: CHD; cd07302 1173027008008 nucleotidyl binding site; other site 1173027008009 metal binding site [ion binding]; metal-binding site 1173027008010 dimer interface [polypeptide binding]; other site 1173027008011 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027008012 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173027008013 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173027008014 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1173027008015 active site lid residues [active] 1173027008016 substrate binding pocket [chemical binding]; other site 1173027008017 catalytic residues [active] 1173027008018 substrate-Mg2+ binding site; other site 1173027008019 aspartate-rich region 1; other site 1173027008020 aspartate-rich region 2; other site 1173027008021 phytoene desaturase; Region: phytoene_desat; TIGR02731 1173027008022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027008023 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 1173027008024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008025 active site 1173027008026 phosphorylation site [posttranslational modification] 1173027008027 intermolecular recognition site; other site 1173027008028 dimerization interface [polypeptide binding]; other site 1173027008029 CheB methylesterase; Region: CheB_methylest; pfam01339 1173027008030 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027008031 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027008032 putative binding surface; other site 1173027008033 active site 1173027008034 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027008035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008036 ATP binding site [chemical binding]; other site 1173027008037 Mg2+ binding site [ion binding]; other site 1173027008038 G-X-G motif; other site 1173027008039 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027008040 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027008041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008042 active site 1173027008043 phosphorylation site [posttranslational modification] 1173027008044 intermolecular recognition site; other site 1173027008045 dimerization interface [polypeptide binding]; other site 1173027008046 CHASE3 domain; Region: CHASE3; pfam05227 1173027008047 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027008048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027008049 dimer interface [polypeptide binding]; other site 1173027008050 putative CheW interface [polypeptide binding]; other site 1173027008051 CheW-like domain; Region: CheW; pfam01584 1173027008052 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027008053 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008055 active site 1173027008056 phosphorylation site [posttranslational modification] 1173027008057 intermolecular recognition site; other site 1173027008058 dimerization interface [polypeptide binding]; other site 1173027008059 Tic20-like protein; Region: Tic20; pfam09685 1173027008060 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1173027008061 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1173027008062 G1 box; other site 1173027008063 putative GEF interaction site [polypeptide binding]; other site 1173027008064 GTP/Mg2+ binding site [chemical binding]; other site 1173027008065 Switch I region; other site 1173027008066 G2 box; other site 1173027008067 G3 box; other site 1173027008068 Switch II region; other site 1173027008069 G4 box; other site 1173027008070 G5 box; other site 1173027008071 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1173027008072 Peptidase family M48; Region: Peptidase_M48; cl12018 1173027008073 GUN4-like; Region: GUN4; pfam05419 1173027008074 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173027008075 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173027008076 putative catalytic cysteine [active] 1173027008077 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027008078 nudix motif; other site 1173027008079 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1173027008080 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1173027008081 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1173027008082 active site 1173027008083 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173027008084 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173027008085 dimer interface [polypeptide binding]; other site 1173027008086 ADP-ribose binding site [chemical binding]; other site 1173027008087 active site 1173027008088 nudix motif; other site 1173027008089 metal binding site [ion binding]; metal-binding site 1173027008090 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1173027008091 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173027008092 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173027008093 NAD(P) binding site [chemical binding]; other site 1173027008094 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027008095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008096 active site 1173027008097 phosphorylation site [posttranslational modification] 1173027008098 intermolecular recognition site; other site 1173027008099 dimerization interface [polypeptide binding]; other site 1173027008100 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008101 PAS domain; Region: PAS_8; pfam13188 1173027008102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008104 dimer interface [polypeptide binding]; other site 1173027008105 phosphorylation site [posttranslational modification] 1173027008106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008107 ATP binding site [chemical binding]; other site 1173027008108 Mg2+ binding site [ion binding]; other site 1173027008109 G-X-G motif; other site 1173027008110 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008112 active site 1173027008113 phosphorylation site [posttranslational modification] 1173027008114 intermolecular recognition site; other site 1173027008115 dimerization interface [polypeptide binding]; other site 1173027008116 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173027008117 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1173027008118 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1173027008119 active site 1173027008120 Zn binding site [ion binding]; other site 1173027008121 sucrose synthase; Region: sucr_synth; TIGR02470 1173027008122 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027008123 putative ADP-binding pocket [chemical binding]; other site 1173027008124 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1173027008125 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027008126 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027008127 Phosphate acyltransferases; Region: PlsC; smart00563 1173027008128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027008129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1173027008130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027008131 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1173027008132 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027008133 active site 1173027008134 metal binding site [ion binding]; metal-binding site 1173027008135 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1173027008136 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027008137 cyclase homology domain; Region: CHD; cd07302 1173027008138 nucleotidyl binding site; other site 1173027008139 metal binding site [ion binding]; metal-binding site 1173027008140 dimer interface [polypeptide binding]; other site 1173027008141 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 1173027008142 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173027008143 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1173027008144 alpha subunit interaction interface [polypeptide binding]; other site 1173027008145 Walker A motif; other site 1173027008146 ATP binding site [chemical binding]; other site 1173027008147 Walker B motif; other site 1173027008148 inhibitor binding site; inhibition site 1173027008149 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173027008150 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 1173027008151 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1173027008152 gamma subunit interface [polypeptide binding]; other site 1173027008153 epsilon subunit interface [polypeptide binding]; other site 1173027008154 LBP interface [polypeptide binding]; other site 1173027008155 hypothetical protein; Provisional; Region: PRK02724 1173027008156 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 1173027008157 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1173027008158 TPR repeat; Region: TPR_11; pfam13414 1173027008159 TPR repeat; Region: TPR_11; pfam13414 1173027008160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027008161 binding surface 1173027008162 TPR motif; other site 1173027008163 TPR repeat; Region: TPR_11; pfam13414 1173027008164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027008165 binding surface 1173027008166 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027008167 TPR motif; other site 1173027008168 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173027008169 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1173027008170 putative ligand binding site [chemical binding]; other site 1173027008171 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173027008172 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173027008173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027008174 TM-ABC transporter signature motif; other site 1173027008175 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173027008176 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173027008177 TM-ABC transporter signature motif; other site 1173027008178 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1173027008179 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173027008180 Walker A/P-loop; other site 1173027008181 ATP binding site [chemical binding]; other site 1173027008182 Q-loop/lid; other site 1173027008183 ABC transporter signature motif; other site 1173027008184 Walker B; other site 1173027008185 D-loop; other site 1173027008186 H-loop/switch region; other site 1173027008187 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1173027008188 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173027008189 Walker A/P-loop; other site 1173027008190 ATP binding site [chemical binding]; other site 1173027008191 Q-loop/lid; other site 1173027008192 ABC transporter signature motif; other site 1173027008193 Walker B; other site 1173027008194 D-loop; other site 1173027008195 H-loop/switch region; other site 1173027008196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027008198 dimerization interface [polypeptide binding]; other site 1173027008199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027008200 dimer interface [polypeptide binding]; other site 1173027008201 phosphorylation site [posttranslational modification] 1173027008202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008203 ATP binding site [chemical binding]; other site 1173027008204 Mg2+ binding site [ion binding]; other site 1173027008205 G-X-G motif; other site 1173027008206 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1173027008207 TrkA-N domain; Region: TrkA_N; pfam02254 1173027008208 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027008209 TrkA-N domain; Region: TrkA_N; pfam02254 1173027008210 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027008211 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008212 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008213 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1173027008214 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1173027008215 alpha-gamma subunit interface [polypeptide binding]; other site 1173027008216 beta-gamma subunit interface [polypeptide binding]; other site 1173027008217 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1173027008218 gamma-beta subunit interface [polypeptide binding]; other site 1173027008219 alpha-beta subunit interface [polypeptide binding]; other site 1173027008220 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 1173027008221 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027008222 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008223 putative active site [active] 1173027008224 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1173027008225 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1173027008226 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1173027008227 subunit interactions [polypeptide binding]; other site 1173027008228 active site 1173027008229 flap region; other site 1173027008230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173027008231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173027008232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027008233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027008234 dimer interface [polypeptide binding]; other site 1173027008235 conserved gate region; other site 1173027008236 putative PBP binding loops; other site 1173027008237 ABC-ATPase subunit interface; other site 1173027008238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027008239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027008240 dimer interface [polypeptide binding]; other site 1173027008241 conserved gate region; other site 1173027008242 putative PBP binding loops; other site 1173027008243 ABC-ATPase subunit interface; other site 1173027008244 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027008245 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173027008246 homoserine kinase; Provisional; Region: PRK01212 1173027008247 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173027008248 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173027008249 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173027008250 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 1173027008251 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 1173027008252 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1173027008253 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173027008254 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1173027008255 active site 1173027008256 dimer interface [polypeptide binding]; other site 1173027008257 motif 1; other site 1173027008258 motif 2; other site 1173027008259 motif 3; other site 1173027008260 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1173027008261 anticodon binding site; other site 1173027008262 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173027008263 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008265 putative active site [active] 1173027008266 heme pocket [chemical binding]; other site 1173027008267 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008268 PAS fold; Region: PAS_4; pfam08448 1173027008269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008270 putative active site [active] 1173027008271 heme pocket [chemical binding]; other site 1173027008272 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027008273 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173027008274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008275 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027008276 putative active site [active] 1173027008277 heme pocket [chemical binding]; other site 1173027008278 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027008279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008280 putative active site [active] 1173027008281 heme pocket [chemical binding]; other site 1173027008282 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008283 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008284 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008285 GAF domain; Region: GAF; pfam01590 1173027008286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008288 dimer interface [polypeptide binding]; other site 1173027008289 phosphorylation site [posttranslational modification] 1173027008290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008291 ATP binding site [chemical binding]; other site 1173027008292 Mg2+ binding site [ion binding]; other site 1173027008293 G-X-G motif; other site 1173027008294 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027008295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008296 active site 1173027008297 phosphorylation site [posttranslational modification] 1173027008298 intermolecular recognition site; other site 1173027008299 dimerization interface [polypeptide binding]; other site 1173027008300 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1173027008301 Right handed beta helix region; Region: Beta_helix; pfam13229 1173027008302 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008303 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027008304 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027008305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008307 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1173027008308 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1173027008309 putative active site [active] 1173027008310 catalytic site [active] 1173027008311 putative metal binding site [ion binding]; other site 1173027008312 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173027008313 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008315 putative active site [active] 1173027008316 heme pocket [chemical binding]; other site 1173027008317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008319 ATP binding site [chemical binding]; other site 1173027008320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008321 G-X-G motif; other site 1173027008322 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 1173027008323 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1173027008324 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1173027008325 putative active site [active] 1173027008326 adenylation catalytic residue [active] 1173027008327 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173027008328 oligomeric interface; other site 1173027008329 putative active site [active] 1173027008330 homodimer interface [polypeptide binding]; other site 1173027008331 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1173027008332 Leucine rich repeat; Region: LRR_8; pfam13855 1173027008333 Leucine rich repeat; Region: LRR_8; pfam13855 1173027008334 chaperone protein DnaJ; Provisional; Region: PRK14299 1173027008335 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027008336 HSP70 interaction site [polypeptide binding]; other site 1173027008337 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173027008338 substrate binding site [polypeptide binding]; other site 1173027008339 dimer interface [polypeptide binding]; other site 1173027008340 AAA domain; Region: AAA_33; pfam13671 1173027008341 AAA domain; Region: AAA_17; pfam13207 1173027008342 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1173027008343 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1173027008344 ligand binding site; other site 1173027008345 oligomer interface; other site 1173027008346 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1173027008347 dimer interface [polypeptide binding]; other site 1173027008348 N-terminal domain interface [polypeptide binding]; other site 1173027008349 sulfate 1 binding site; other site 1173027008350 polyphosphate kinase; Provisional; Region: PRK05443 1173027008351 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1173027008352 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1173027008353 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1173027008354 putative domain interface [polypeptide binding]; other site 1173027008355 putative active site [active] 1173027008356 catalytic site [active] 1173027008357 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1173027008358 putative domain interface [polypeptide binding]; other site 1173027008359 putative active site [active] 1173027008360 catalytic site [active] 1173027008361 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173027008362 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173027008363 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173027008364 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1173027008365 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1173027008366 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173027008367 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1173027008368 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1173027008369 HD domain; Region: HD; pfam01966 1173027008370 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027008371 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008372 structural tetrad; other site 1173027008373 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027008374 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008375 structural tetrad; other site 1173027008376 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027008377 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027008378 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027008379 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008380 structural tetrad; other site 1173027008381 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008382 structural tetrad; other site 1173027008383 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008384 structural tetrad; other site 1173027008385 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027008386 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008387 structural tetrad; other site 1173027008388 WD40 repeats; Region: WD40; smart00320 1173027008389 WD40 repeats; Region: WD40; smart00320 1173027008390 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027008391 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008392 putative active site [active] 1173027008393 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027008394 cyclase homology domain; Region: CHD; cd07302 1173027008395 nucleotidyl binding site; other site 1173027008396 metal binding site [ion binding]; metal-binding site 1173027008397 dimer interface [polypeptide binding]; other site 1173027008398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008399 PAS fold; Region: PAS_3; pfam08447 1173027008400 putative active site [active] 1173027008401 heme pocket [chemical binding]; other site 1173027008402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008403 PAS fold; Region: PAS_3; pfam08447 1173027008404 putative active site [active] 1173027008405 heme pocket [chemical binding]; other site 1173027008406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008407 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008409 dimer interface [polypeptide binding]; other site 1173027008410 phosphorylation site [posttranslational modification] 1173027008411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008412 ATP binding site [chemical binding]; other site 1173027008413 Mg2+ binding site [ion binding]; other site 1173027008414 G-X-G motif; other site 1173027008415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008416 PAS fold; Region: PAS_3; pfam08447 1173027008417 putative active site [active] 1173027008418 heme pocket [chemical binding]; other site 1173027008419 GAF domain; Region: GAF; cl17456 1173027008420 PAS fold; Region: PAS_4; pfam08448 1173027008421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008422 putative active site [active] 1173027008423 heme pocket [chemical binding]; other site 1173027008424 PAS fold; Region: PAS_4; pfam08448 1173027008425 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027008426 cyclase homology domain; Region: CHD; cd07302 1173027008427 nucleotidyl binding site; other site 1173027008428 metal binding site [ion binding]; metal-binding site 1173027008429 dimer interface [polypeptide binding]; other site 1173027008430 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1173027008431 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173027008432 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1173027008433 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173027008434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027008435 Walker A motif; other site 1173027008436 ATP binding site [chemical binding]; other site 1173027008437 Walker B motif; other site 1173027008438 arginine finger; other site 1173027008439 AAA ATPase domain; Region: AAA_16; pfam13191 1173027008440 NB-ARC domain; Region: NB-ARC; pfam00931 1173027008441 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027008442 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008443 structural tetrad; other site 1173027008444 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027008445 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008446 structural tetrad; other site 1173027008447 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027008448 structural tetrad; other site 1173027008449 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1173027008450 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008452 putative active site [active] 1173027008453 heme pocket [chemical binding]; other site 1173027008454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008455 PAS fold; Region: PAS_3; pfam08447 1173027008456 putative active site [active] 1173027008457 heme pocket [chemical binding]; other site 1173027008458 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008459 PAS domain; Region: PAS; smart00091 1173027008460 putative active site [active] 1173027008461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008462 PAS fold; Region: PAS_3; pfam08447 1173027008463 putative active site [active] 1173027008464 heme pocket [chemical binding]; other site 1173027008465 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008467 putative active site [active] 1173027008468 heme pocket [chemical binding]; other site 1173027008469 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008471 putative active site [active] 1173027008472 heme pocket [chemical binding]; other site 1173027008473 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008475 putative active site [active] 1173027008476 heme pocket [chemical binding]; other site 1173027008477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008478 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008480 dimer interface [polypeptide binding]; other site 1173027008481 phosphorylation site [posttranslational modification] 1173027008482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008483 ATP binding site [chemical binding]; other site 1173027008484 Mg2+ binding site [ion binding]; other site 1173027008485 G-X-G motif; other site 1173027008486 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008488 active site 1173027008489 phosphorylation site [posttranslational modification] 1173027008490 intermolecular recognition site; other site 1173027008491 dimerization interface [polypeptide binding]; other site 1173027008492 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008494 active site 1173027008495 phosphorylation site [posttranslational modification] 1173027008496 intermolecular recognition site; other site 1173027008497 dimerization interface [polypeptide binding]; other site 1173027008498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008499 dimer interface [polypeptide binding]; other site 1173027008500 phosphorylation site [posttranslational modification] 1173027008501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008502 ATP binding site [chemical binding]; other site 1173027008503 Mg2+ binding site [ion binding]; other site 1173027008504 G-X-G motif; other site 1173027008505 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173027008506 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173027008507 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1173027008508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008509 GAF domain; Region: GAF; pfam01590 1173027008510 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1173027008511 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1173027008512 quinone interaction residues [chemical binding]; other site 1173027008513 active site 1173027008514 catalytic residues [active] 1173027008515 FMN binding site [chemical binding]; other site 1173027008516 substrate binding site [chemical binding]; other site 1173027008517 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008519 active site 1173027008520 phosphorylation site [posttranslational modification] 1173027008521 intermolecular recognition site; other site 1173027008522 dimerization interface [polypeptide binding]; other site 1173027008523 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027008524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008525 active site 1173027008526 phosphorylation site [posttranslational modification] 1173027008527 intermolecular recognition site; other site 1173027008528 dimerization interface [polypeptide binding]; other site 1173027008529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027008530 DNA binding residues [nucleotide binding] 1173027008531 dimerization interface [polypeptide binding]; other site 1173027008532 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027008533 active site 1173027008534 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008535 putative active site [active] 1173027008536 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1173027008537 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1173027008538 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1173027008539 substrate binding pocket [chemical binding]; other site 1173027008540 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1173027008541 B12 binding site [chemical binding]; other site 1173027008542 cobalt ligand [ion binding]; other site 1173027008543 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1173027008544 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008545 putative active site [active] 1173027008546 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027008547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027008548 non-specific DNA binding site [nucleotide binding]; other site 1173027008549 salt bridge; other site 1173027008550 sequence-specific DNA binding site [nucleotide binding]; other site 1173027008551 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008552 putative active site [active] 1173027008553 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173027008554 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173027008555 metal binding site [ion binding]; metal-binding site 1173027008556 dimer interface [polypeptide binding]; other site 1173027008557 AAA domain; Region: AAA_26; pfam13500 1173027008558 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173027008559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027008560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027008561 active site 1173027008562 ATP binding site [chemical binding]; other site 1173027008563 substrate binding site [chemical binding]; other site 1173027008564 activation loop (A-loop); other site 1173027008565 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1173027008566 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1173027008567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027008568 active site 1173027008569 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1173027008570 Protein of unknown function (DUF98); Region: DUF98; pfam01947 1173027008571 amidophosphoribosyltransferase; Provisional; Region: PRK07349 1173027008572 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1173027008573 active site 1173027008574 tetramer interface [polypeptide binding]; other site 1173027008575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027008576 active site 1173027008577 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1173027008578 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1173027008579 dimerization interface [polypeptide binding]; other site 1173027008580 ATP binding site [chemical binding]; other site 1173027008581 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1173027008582 dimerization interface [polypeptide binding]; other site 1173027008583 ATP binding site [chemical binding]; other site 1173027008584 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1173027008585 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1173027008586 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027008587 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027008588 cofactor binding site; other site 1173027008589 DNA binding site [nucleotide binding] 1173027008590 substrate interaction site [chemical binding]; other site 1173027008591 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 1173027008592 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1173027008593 four helix bundle protein; Region: TIGR02436 1173027008594 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173027008595 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173027008596 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173027008597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027008598 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1173027008599 putative NAD(P) binding site [chemical binding]; other site 1173027008600 active site 1173027008601 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1173027008602 Beta-lactamase; Region: Beta-lactamase; pfam00144 1173027008603 PRC-barrel domain; Region: PRC; pfam05239 1173027008604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173027008605 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1173027008606 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173027008607 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173027008608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027008609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027008610 ligand binding site [chemical binding]; other site 1173027008611 flexible hinge region; other site 1173027008612 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027008613 putative switch regulator; other site 1173027008614 non-specific DNA interactions [nucleotide binding]; other site 1173027008615 DNA binding site [nucleotide binding] 1173027008616 sequence specific DNA binding site [nucleotide binding]; other site 1173027008617 putative cAMP binding site [chemical binding]; other site 1173027008618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027008619 Ligand Binding Site [chemical binding]; other site 1173027008620 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1173027008621 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1173027008622 putative dimer interface [polypeptide binding]; other site 1173027008623 active site pocket [active] 1173027008624 CpeS-like protein; Region: CpeS; pfam09367 1173027008625 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173027008626 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1173027008627 S-layer homology domain; Region: SLH; pfam00395 1173027008628 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027008629 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1173027008630 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1173027008631 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027008632 nudix motif; other site 1173027008633 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1173027008634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027008635 Walker A motif; other site 1173027008636 ATP binding site [chemical binding]; other site 1173027008637 Walker B motif; other site 1173027008638 arginine finger; other site 1173027008639 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1173027008640 Homeodomain-like domain; Region: HTH_23; pfam13384 1173027008641 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1173027008642 heme-binding site [chemical binding]; other site 1173027008643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008644 PAS domain; Region: PAS_9; pfam13426 1173027008645 putative active site [active] 1173027008646 heme pocket [chemical binding]; other site 1173027008647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008648 PAS domain; Region: PAS_9; pfam13426 1173027008649 putative active site [active] 1173027008650 heme pocket [chemical binding]; other site 1173027008651 PAS fold; Region: PAS_4; pfam08448 1173027008652 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008653 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008656 dimer interface [polypeptide binding]; other site 1173027008657 phosphorylation site [posttranslational modification] 1173027008658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008659 ATP binding site [chemical binding]; other site 1173027008660 Mg2+ binding site [ion binding]; other site 1173027008661 G-X-G motif; other site 1173027008662 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173027008663 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173027008664 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173027008665 Ligand binding site; other site 1173027008666 Putative Catalytic site; other site 1173027008667 DXD motif; other site 1173027008668 Predicted integral membrane protein [Function unknown]; Region: COG5542 1173027008669 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027008670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027008671 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1173027008672 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173027008673 NADP binding site [chemical binding]; other site 1173027008674 active site 1173027008675 putative substrate binding site [chemical binding]; other site 1173027008676 glycine dehydrogenase; Provisional; Region: PRK05367 1173027008677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173027008678 tetramer interface [polypeptide binding]; other site 1173027008679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027008680 catalytic residue [active] 1173027008681 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173027008682 tetramer interface [polypeptide binding]; other site 1173027008683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027008684 catalytic residue [active] 1173027008685 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1173027008686 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1173027008687 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1173027008688 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1173027008689 putative NAD(P) binding site [chemical binding]; other site 1173027008690 active site 1173027008691 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1173027008692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173027008693 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027008694 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173027008695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027008696 motif II; other site 1173027008697 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173027008698 EF-hand domain pair; Region: EF_hand_5; pfam13499 1173027008699 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1173027008700 Ca2+ binding site [ion binding]; other site 1173027008701 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027008702 Cytochrome P450; Region: p450; pfam00067 1173027008703 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1173027008704 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1173027008705 homodimer interface [polypeptide binding]; other site 1173027008706 metal binding site [ion binding]; metal-binding site 1173027008707 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1173027008708 homodimer interface [polypeptide binding]; other site 1173027008709 active site 1173027008710 putative chemical substrate binding site [chemical binding]; other site 1173027008711 metal binding site [ion binding]; metal-binding site 1173027008712 Biofilm formation and stress response factor; Region: BsmA; cl01794 1173027008713 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1173027008714 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173027008715 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027008716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027008717 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173027008718 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027008719 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027008720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027008721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008722 dimer interface [polypeptide binding]; other site 1173027008723 phosphorylation site [posttranslational modification] 1173027008724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008725 ATP binding site [chemical binding]; other site 1173027008726 Mg2+ binding site [ion binding]; other site 1173027008727 G-X-G motif; other site 1173027008728 PsaD; Region: PsaD; pfam02531 1173027008729 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1173027008730 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173027008731 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173027008732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027008733 non-specific DNA binding site [nucleotide binding]; other site 1173027008734 salt bridge; other site 1173027008735 sequence-specific DNA binding site [nucleotide binding]; other site 1173027008736 ADP-glucose phosphorylase; Region: PLN02643 1173027008737 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1173027008738 nucleotide binding site/active site [active] 1173027008739 HIT family signature motif; other site 1173027008740 catalytic residue [active] 1173027008741 HEAT repeats; Region: HEAT_2; pfam13646 1173027008742 HEAT repeats; Region: HEAT_2; pfam13646 1173027008743 HEAT repeats; Region: HEAT_2; pfam13646 1173027008744 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027008745 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027008746 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1173027008747 active site 1173027008748 catalytic triad [active] 1173027008749 oxyanion hole [active] 1173027008750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027008751 non-specific DNA binding site [nucleotide binding]; other site 1173027008752 salt bridge; other site 1173027008753 sequence-specific DNA binding site [nucleotide binding]; other site 1173027008754 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008755 PAS fold; Region: PAS_3; pfam08447 1173027008756 putative active site [active] 1173027008757 heme pocket [chemical binding]; other site 1173027008758 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008760 putative active site [active] 1173027008761 heme pocket [chemical binding]; other site 1173027008762 PAS fold; Region: PAS_4; pfam08448 1173027008763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008764 dimer interface [polypeptide binding]; other site 1173027008765 phosphorylation site [posttranslational modification] 1173027008766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008767 ATP binding site [chemical binding]; other site 1173027008768 Mg2+ binding site [ion binding]; other site 1173027008769 G-X-G motif; other site 1173027008770 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027008771 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027008772 active site 1173027008773 metal binding site [ion binding]; metal-binding site 1173027008774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1173027008775 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173027008776 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173027008777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173027008778 Transporter associated domain; Region: CorC_HlyC; smart01091 1173027008779 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1173027008780 MutS domain I; Region: MutS_I; pfam01624 1173027008781 MutS domain II; Region: MutS_II; pfam05188 1173027008782 MutS domain III; Region: MutS_III; pfam05192 1173027008783 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1173027008784 Walker A/P-loop; other site 1173027008785 ATP binding site [chemical binding]; other site 1173027008786 Q-loop/lid; other site 1173027008787 ABC transporter signature motif; other site 1173027008788 Walker B; other site 1173027008789 D-loop; other site 1173027008790 H-loop/switch region; other site 1173027008791 FAD binding domain; Region: FAD_binding_3; pfam01494 1173027008792 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173027008793 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173027008794 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027008795 active site 1173027008796 NTP binding site [chemical binding]; other site 1173027008797 metal binding triad [ion binding]; metal-binding site 1173027008798 antibiotic binding site [chemical binding]; other site 1173027008799 Predicted GTPase [General function prediction only]; Region: COG3596 1173027008800 YfjP GTPase; Region: YfjP; cd11383 1173027008801 G1 box; other site 1173027008802 GTP/Mg2+ binding site [chemical binding]; other site 1173027008803 Switch I region; other site 1173027008804 G2 box; other site 1173027008805 Switch II region; other site 1173027008806 G3 box; other site 1173027008807 G4 box; other site 1173027008808 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027008809 TrkA-N domain; Region: TrkA_N; pfam02254 1173027008810 TrkA-C domain; Region: TrkA_C; pfam02080 1173027008811 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173027008812 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1173027008813 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 1173027008814 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008816 active site 1173027008817 phosphorylation site [posttranslational modification] 1173027008818 intermolecular recognition site; other site 1173027008819 dimerization interface [polypeptide binding]; other site 1173027008820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008821 PAS fold; Region: PAS_3; pfam08447 1173027008822 putative active site [active] 1173027008823 heme pocket [chemical binding]; other site 1173027008824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008825 dimer interface [polypeptide binding]; other site 1173027008826 phosphorylation site [posttranslational modification] 1173027008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008828 ATP binding site [chemical binding]; other site 1173027008829 Mg2+ binding site [ion binding]; other site 1173027008830 G-X-G motif; other site 1173027008831 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008833 active site 1173027008834 phosphorylation site [posttranslational modification] 1173027008835 intermolecular recognition site; other site 1173027008836 dimerization interface [polypeptide binding]; other site 1173027008837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008838 dimer interface [polypeptide binding]; other site 1173027008839 phosphorylation site [posttranslational modification] 1173027008840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008841 ATP binding site [chemical binding]; other site 1173027008842 Mg2+ binding site [ion binding]; other site 1173027008843 G-X-G motif; other site 1173027008844 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008846 active site 1173027008847 phosphorylation site [posttranslational modification] 1173027008848 intermolecular recognition site; other site 1173027008849 dimerization interface [polypeptide binding]; other site 1173027008850 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008852 active site 1173027008853 phosphorylation site [posttranslational modification] 1173027008854 intermolecular recognition site; other site 1173027008855 dimerization interface [polypeptide binding]; other site 1173027008856 PAS fold; Region: PAS_4; pfam08448 1173027008857 PAS fold; Region: PAS_4; pfam08448 1173027008858 PAS domain S-box; Region: sensory_box; TIGR00229 1173027008859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027008860 putative active site [active] 1173027008861 heme pocket [chemical binding]; other site 1173027008862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027008863 dimer interface [polypeptide binding]; other site 1173027008864 phosphorylation site [posttranslational modification] 1173027008865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008866 ATP binding site [chemical binding]; other site 1173027008867 Mg2+ binding site [ion binding]; other site 1173027008868 G-X-G motif; other site 1173027008869 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027008870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008871 active site 1173027008872 phosphorylation site [posttranslational modification] 1173027008873 intermolecular recognition site; other site 1173027008874 dimerization interface [polypeptide binding]; other site 1173027008875 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173027008876 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173027008877 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173027008878 putative dimer interface [polypeptide binding]; other site 1173027008879 N-terminal domain interface [polypeptide binding]; other site 1173027008880 putative substrate binding pocket (H-site) [chemical binding]; other site 1173027008881 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1173027008882 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 1173027008883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027008884 binding surface 1173027008885 TPR motif; other site 1173027008886 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173027008887 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173027008888 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1173027008889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027008890 Walker A motif; other site 1173027008891 ATP binding site [chemical binding]; other site 1173027008892 Walker B motif; other site 1173027008893 arginine finger; other site 1173027008894 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1173027008895 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1173027008896 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1173027008897 substrate binding site [chemical binding]; other site 1173027008898 glutamase interaction surface [polypeptide binding]; other site 1173027008899 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027008900 putative binding surface; other site 1173027008901 active site 1173027008902 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027008903 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027008904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008905 ATP binding site [chemical binding]; other site 1173027008906 Mg2+ binding site [ion binding]; other site 1173027008907 G-X-G motif; other site 1173027008908 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1173027008909 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008911 active site 1173027008912 phosphorylation site [posttranslational modification] 1173027008913 intermolecular recognition site; other site 1173027008914 dimerization interface [polypeptide binding]; other site 1173027008915 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1173027008916 Stage II sporulation protein; Region: SpoIID; pfam08486 1173027008917 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027008918 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027008919 catalytic loop [active] 1173027008920 iron binding site [ion binding]; other site 1173027008921 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173027008922 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1173027008923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027008924 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1173027008925 FeS/SAM binding site; other site 1173027008926 Amidohydrolase; Region: Amidohydro_2; pfam04909 1173027008927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027008928 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027008929 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173027008930 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1173027008931 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1173027008932 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1173027008933 tetramer interface [polypeptide binding]; other site 1173027008934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027008935 catalytic residue [active] 1173027008936 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027008937 putative active site [active] 1173027008938 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1173027008939 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1173027008940 TPP-binding site [chemical binding]; other site 1173027008941 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1173027008942 Cytochrome P450; Region: p450; cl12078 1173027008943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027008944 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027008945 Cytochrome P450; Region: p450; pfam00067 1173027008946 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173027008947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027008948 Mg2+ binding site [ion binding]; other site 1173027008949 G-X-G motif; other site 1173027008950 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027008951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027008952 active site 1173027008953 phosphorylation site [posttranslational modification] 1173027008954 intermolecular recognition site; other site 1173027008955 dimerization interface [polypeptide binding]; other site 1173027008956 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027008957 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027008958 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173027008959 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173027008960 anti sigma factor interaction site; other site 1173027008961 regulatory phosphorylation site [posttranslational modification]; other site 1173027008962 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173027008963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027008964 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1173027008965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027008966 NAD(P) binding site [chemical binding]; other site 1173027008967 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1173027008968 heme-binding site [chemical binding]; other site 1173027008969 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173027008970 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027008971 G1 box; other site 1173027008972 GTP/Mg2+ binding site [chemical binding]; other site 1173027008973 G2 box; other site 1173027008974 Switch I region; other site 1173027008975 G3 box; other site 1173027008976 Switch II region; other site 1173027008977 G4 box; other site 1173027008978 V4R domain; Region: V4R; cl15268 1173027008979 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173027008980 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027008981 G1 box; other site 1173027008982 GTP/Mg2+ binding site [chemical binding]; other site 1173027008983 G2 box; other site 1173027008984 Switch I region; other site 1173027008985 G3 box; other site 1173027008986 Switch II region; other site 1173027008987 G4 box; other site 1173027008988 AAA ATPase domain; Region: AAA_16; pfam13191 1173027008989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027008990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027008991 binding surface 1173027008992 TPR motif; other site 1173027008993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027008994 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1173027008995 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1173027008996 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1173027008997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173027008998 S-layer homology domain; Region: SLH; pfam00395 1173027008999 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027009000 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027009001 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1173027009002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027009003 active site 1173027009004 metal binding site [ion binding]; metal-binding site 1173027009005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027009006 S-adenosylmethionine binding site [chemical binding]; other site 1173027009007 Protein of unknown function (DUF433); Region: DUF433; cl01030 1173027009008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173027009009 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1173027009010 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027009011 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 1173027009012 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1173027009013 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1173027009014 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1173027009015 putative active site [active] 1173027009016 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1173027009017 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1173027009018 active site 1173027009019 zinc binding site [ion binding]; other site 1173027009020 S-layer homology domain; Region: SLH; pfam00395 1173027009021 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027009022 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173027009023 metal binding site 2 [ion binding]; metal-binding site 1173027009024 putative DNA binding helix; other site 1173027009025 metal binding site 1 [ion binding]; metal-binding site 1173027009026 dimer interface [polypeptide binding]; other site 1173027009027 structural Zn2+ binding site [ion binding]; other site 1173027009028 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1173027009029 dimer interface [polypeptide binding]; other site 1173027009030 active site 1173027009031 aspartate-rich active site metal binding site; other site 1173027009032 allosteric magnesium binding site [ion binding]; other site 1173027009033 Schiff base residues; other site 1173027009034 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1173027009035 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1173027009036 metal binding site [ion binding]; metal-binding site 1173027009037 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173027009038 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173027009039 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173027009040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173027009041 putative PBP binding regions; other site 1173027009042 ABC-ATPase subunit interface; other site 1173027009043 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173027009044 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173027009045 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027009046 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173027009047 homodecamer interface [polypeptide binding]; other site 1173027009048 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173027009049 active site 1173027009050 putative catalytic site residues [active] 1173027009051 zinc binding site [ion binding]; other site 1173027009052 GTP-CH-I/GFRP interaction surface; other site 1173027009053 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173027009054 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173027009055 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027009056 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1173027009057 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173027009058 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1173027009059 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173027009060 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173027009061 trimer interface [polypeptide binding]; other site 1173027009062 active site 1173027009063 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 1173027009064 putative multimerization interface [polypeptide binding]; other site 1173027009065 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1173027009066 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173027009067 active site 1173027009068 HIGH motif; other site 1173027009069 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173027009070 KMSKS motif; other site 1173027009071 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1173027009072 tRNA binding surface [nucleotide binding]; other site 1173027009073 anticodon binding site; other site 1173027009074 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027009075 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027009076 structural tetrad; other site 1173027009077 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 1173027009078 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027009079 G1 box; other site 1173027009080 GTP/Mg2+ binding site [chemical binding]; other site 1173027009081 G2 box; other site 1173027009082 Switch I region; other site 1173027009083 G3 box; other site 1173027009084 Switch II region; other site 1173027009085 G4 box; other site 1173027009086 G5 box; other site 1173027009087 Nucleoside recognition; Region: Gate; pfam07670 1173027009088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1173027009089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1173027009090 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173027009091 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1173027009092 active site 1173027009093 dimer interface [polypeptide binding]; other site 1173027009094 motif 1; other site 1173027009095 motif 2; other site 1173027009096 motif 3; other site 1173027009097 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1173027009098 anticodon binding site; other site 1173027009099 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1173027009100 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027009101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009103 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173027009104 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173027009105 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027009106 active site 1173027009107 NTP binding site [chemical binding]; other site 1173027009108 metal binding triad [ion binding]; metal-binding site 1173027009109 antibiotic binding site [chemical binding]; other site 1173027009110 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1173027009111 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1173027009112 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173027009113 Subunit I/III interface [polypeptide binding]; other site 1173027009114 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173027009115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027009116 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1173027009117 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1173027009118 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173027009119 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027009120 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173027009121 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173027009122 iron-sulfur cluster [ion binding]; other site 1173027009123 [2Fe-2S] cluster binding site [ion binding]; other site 1173027009124 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1173027009125 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1173027009126 putative dimer interface [polypeptide binding]; other site 1173027009127 [2Fe-2S] cluster binding site [ion binding]; other site 1173027009128 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027009129 dimer interface [polypeptide binding]; other site 1173027009130 [2Fe-2S] cluster binding site [ion binding]; other site 1173027009131 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1173027009132 SLBB domain; Region: SLBB; pfam10531 1173027009133 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1173027009134 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1173027009135 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027009136 catalytic loop [active] 1173027009137 iron binding site [ion binding]; other site 1173027009138 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1173027009139 4Fe-4S binding domain; Region: Fer4; pfam00037 1173027009140 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 1173027009141 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1173027009142 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1173027009143 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1173027009144 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 1173027009145 nickel binding site [ion binding]; other site 1173027009146 CP12 domain; Region: CP12; pfam02672 1173027009147 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1173027009148 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1173027009149 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 1173027009150 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1173027009151 Acylphosphatase; Region: Acylphosphatase; pfam00708 1173027009152 HypF finger; Region: zf-HYPF; pfam07503 1173027009153 HypF finger; Region: zf-HYPF; pfam07503 1173027009154 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1173027009155 HupF/HypC family; Region: HupF_HypC; pfam01455 1173027009156 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1173027009157 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1173027009158 dimer interface [polypeptide binding]; other site 1173027009159 PYR/PP interface [polypeptide binding]; other site 1173027009160 TPP binding site [chemical binding]; other site 1173027009161 substrate binding site [chemical binding]; other site 1173027009162 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1173027009163 Domain of unknown function; Region: EKR; pfam10371 1173027009164 4Fe-4S binding domain; Region: Fer4; pfam00037 1173027009165 4Fe-4S binding domain; Region: Fer4; pfam00037 1173027009166 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1173027009167 TPP-binding site [chemical binding]; other site 1173027009168 dimer interface [polypeptide binding]; other site 1173027009169 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1173027009170 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1173027009171 putative active site [active] 1173027009172 putative FMN binding site [chemical binding]; other site 1173027009173 putative substrate binding site [chemical binding]; other site 1173027009174 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1173027009175 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1173027009176 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1173027009177 dimerization interface [polypeptide binding]; other site 1173027009178 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1173027009179 ATP binding site [chemical binding]; other site 1173027009180 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1173027009181 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173027009182 active site 1173027009183 ADP/pyrophosphate binding site [chemical binding]; other site 1173027009184 dimerization interface [polypeptide binding]; other site 1173027009185 allosteric effector site; other site 1173027009186 fructose-1,6-bisphosphate binding site; other site 1173027009187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027009188 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1173027009189 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1173027009190 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1173027009191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173027009192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1173027009193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027009194 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1173027009195 dimer interface [polypeptide binding]; other site 1173027009196 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1173027009197 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173027009198 putative C-terminal domain interface [polypeptide binding]; other site 1173027009199 putative GSH binding site (G-site) [chemical binding]; other site 1173027009200 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027009201 putative dimer interface [polypeptide binding]; other site 1173027009202 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027009203 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1173027009204 putative dimer interface [polypeptide binding]; other site 1173027009205 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1173027009206 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173027009207 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027009208 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 1173027009209 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027009210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009211 active site 1173027009212 phosphorylation site [posttranslational modification] 1173027009213 intermolecular recognition site; other site 1173027009214 dimerization interface [polypeptide binding]; other site 1173027009215 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009217 active site 1173027009218 phosphorylation site [posttranslational modification] 1173027009219 intermolecular recognition site; other site 1173027009220 dimerization interface [polypeptide binding]; other site 1173027009221 PAS fold; Region: PAS_2; pfam08446 1173027009222 GAF domain; Region: GAF; pfam01590 1173027009223 Phytochrome region; Region: PHY; pfam00360 1173027009224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009225 PAS fold; Region: PAS_3; pfam08447 1173027009226 putative active site [active] 1173027009227 heme pocket [chemical binding]; other site 1173027009228 PAS domain; Region: PAS; smart00091 1173027009229 PAS domain; Region: PAS_9; pfam13426 1173027009230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009231 putative active site [active] 1173027009232 heme pocket [chemical binding]; other site 1173027009233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009234 PAS fold; Region: PAS_3; pfam08447 1173027009235 putative active site [active] 1173027009236 heme pocket [chemical binding]; other site 1173027009237 PAS domain; Region: PAS_9; pfam13426 1173027009238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009239 putative active site [active] 1173027009240 heme pocket [chemical binding]; other site 1173027009241 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027009242 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027009243 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027009244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009245 putative active site [active] 1173027009246 heme pocket [chemical binding]; other site 1173027009247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009248 dimer interface [polypeptide binding]; other site 1173027009249 phosphorylation site [posttranslational modification] 1173027009250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009251 ATP binding site [chemical binding]; other site 1173027009252 Mg2+ binding site [ion binding]; other site 1173027009253 G-X-G motif; other site 1173027009254 GAF domain; Region: GAF; pfam01590 1173027009255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009257 dimer interface [polypeptide binding]; other site 1173027009258 phosphorylation site [posttranslational modification] 1173027009259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009260 ATP binding site [chemical binding]; other site 1173027009261 Mg2+ binding site [ion binding]; other site 1173027009262 G-X-G motif; other site 1173027009263 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009265 active site 1173027009266 phosphorylation site [posttranslational modification] 1173027009267 intermolecular recognition site; other site 1173027009268 dimerization interface [polypeptide binding]; other site 1173027009269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027009270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009271 active site 1173027009272 phosphorylation site [posttranslational modification] 1173027009273 intermolecular recognition site; other site 1173027009274 dimerization interface [polypeptide binding]; other site 1173027009275 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027009276 DNA binding site [nucleotide binding] 1173027009277 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027009278 putative binding surface; other site 1173027009279 active site 1173027009280 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009282 active site 1173027009283 phosphorylation site [posttranslational modification] 1173027009284 intermolecular recognition site; other site 1173027009285 dimerization interface [polypeptide binding]; other site 1173027009286 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009288 active site 1173027009289 phosphorylation site [posttranslational modification] 1173027009290 intermolecular recognition site; other site 1173027009291 dimerization interface [polypeptide binding]; other site 1173027009292 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027009293 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027009294 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173027009295 Predicted transcriptional regulator [Transcription]; Region: COG3682 1173027009296 cytochrome c6; Provisional; Region: PRK13697 1173027009297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009298 TPR motif; other site 1173027009299 binding surface 1173027009300 TPR repeat; Region: TPR_11; pfam13414 1173027009301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009302 binding surface 1173027009303 TPR motif; other site 1173027009304 TPR repeat; Region: TPR_11; pfam13414 1173027009305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009306 binding surface 1173027009307 TPR motif; other site 1173027009308 TPR repeat; Region: TPR_11; pfam13414 1173027009309 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1173027009310 AMIN domain; Region: AMIN; pfam11741 1173027009311 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173027009312 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173027009313 N-terminal plug; other site 1173027009314 ligand-binding site [chemical binding]; other site 1173027009315 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1173027009316 muropeptide transporter; Validated; Region: ampG; cl17669 1173027009317 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1173027009318 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173027009319 XisH protein; Region: XisH; pfam08814 1173027009320 XisI protein; Region: XisI; pfam08869 1173027009321 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173027009322 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1173027009323 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1173027009324 THF binding site; other site 1173027009325 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1173027009326 substrate binding site [chemical binding]; other site 1173027009327 THF binding site; other site 1173027009328 zinc-binding site [ion binding]; other site 1173027009329 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027009330 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027009331 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1173027009332 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1173027009333 TPR repeat; Region: TPR_11; pfam13414 1173027009334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009335 TPR motif; other site 1173027009336 binding surface 1173027009337 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027009338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009339 binding surface 1173027009340 TPR motif; other site 1173027009341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009342 binding surface 1173027009343 TPR motif; other site 1173027009344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009345 binding surface 1173027009346 TPR motif; other site 1173027009347 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 1173027009348 dimer interface [polypeptide binding]; other site 1173027009349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027009350 ligand binding site [chemical binding]; other site 1173027009351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027009352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173027009353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173027009354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173027009355 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027009356 dimer interface [polypeptide binding]; other site 1173027009357 [2Fe-2S] cluster binding site [ion binding]; other site 1173027009358 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1173027009359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027009360 active site 1173027009361 metal binding site [ion binding]; metal-binding site 1173027009362 hexamer interface [polypeptide binding]; other site 1173027009363 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173027009364 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173027009365 P-loop, Walker A motif; other site 1173027009366 Base recognition motif; other site 1173027009367 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027009368 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027009369 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027009370 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027009371 structural tetrad; other site 1173027009372 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173027009373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173027009374 Walker A/P-loop; other site 1173027009375 ATP binding site [chemical binding]; other site 1173027009376 Q-loop/lid; other site 1173027009377 ABC transporter signature motif; other site 1173027009378 Walker B; other site 1173027009379 D-loop; other site 1173027009380 H-loop/switch region; other site 1173027009381 DevC protein; Region: devC; TIGR01185 1173027009382 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027009383 FtsX-like permease family; Region: FtsX; pfam02687 1173027009384 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173027009385 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027009386 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1173027009387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173027009388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173027009389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027009390 active site 1173027009391 ATP binding site [chemical binding]; other site 1173027009392 substrate binding site [chemical binding]; other site 1173027009393 Protein kinase domain; Region: Pkinase; pfam00069 1173027009394 activation loop (A-loop); other site 1173027009395 AAA ATPase domain; Region: AAA_16; pfam13191 1173027009396 Predicted ATPase [General function prediction only]; Region: COG3899 1173027009397 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027009398 GAF domain; Region: GAF; pfam01590 1173027009399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009401 ATP binding site [chemical binding]; other site 1173027009402 Mg2+ binding site [ion binding]; other site 1173027009403 G-X-G motif; other site 1173027009404 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1173027009405 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1173027009406 homodimer interface [polypeptide binding]; other site 1173027009407 substrate-cofactor binding pocket; other site 1173027009408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027009409 catalytic residue [active] 1173027009410 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173027009411 putative catalytic site [active] 1173027009412 putative metal binding site [ion binding]; other site 1173027009413 putative phosphate binding site [ion binding]; other site 1173027009414 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1173027009415 Lamin Tail Domain; Region: LTD; pfam00932 1173027009416 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1173027009417 AIR carboxylase; Region: AIRC; smart01001 1173027009418 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173027009419 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173027009420 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173027009421 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173027009422 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009423 putative active site [active] 1173027009424 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027009425 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173027009426 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1173027009427 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1173027009428 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1173027009429 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1173027009430 active site 1173027009431 catalytic site [active] 1173027009432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173027009433 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 1173027009434 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173027009435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173027009436 Walker A/P-loop; other site 1173027009437 ATP binding site [chemical binding]; other site 1173027009438 Q-loop/lid; other site 1173027009439 ABC transporter signature motif; other site 1173027009440 Walker B; other site 1173027009441 D-loop; other site 1173027009442 H-loop/switch region; other site 1173027009443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009445 active site 1173027009446 phosphorylation site [posttranslational modification] 1173027009447 intermolecular recognition site; other site 1173027009448 dimerization interface [polypeptide binding]; other site 1173027009449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027009450 DNA binding site [nucleotide binding] 1173027009451 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1173027009452 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173027009453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027009454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027009455 catalytic residue [active] 1173027009456 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173027009457 classical (c) SDRs; Region: SDR_c; cd05233 1173027009458 NAD(P) binding site [chemical binding]; other site 1173027009459 active site 1173027009460 Sporulation and spore germination; Region: Germane; pfam10646 1173027009461 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1173027009462 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173027009463 active site 1173027009464 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173027009465 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1173027009466 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173027009467 DNA binding residues [nucleotide binding] 1173027009468 putative dimer interface [polypeptide binding]; other site 1173027009469 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009470 putative active site [active] 1173027009471 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1173027009472 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009473 putative active site [active] 1173027009474 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1173027009475 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027009476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027009477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1173027009478 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1173027009479 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027009480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009482 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027009483 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1173027009484 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173027009485 E3 interaction surface; other site 1173027009486 lipoyl attachment site [posttranslational modification]; other site 1173027009487 e3 binding domain; Region: E3_binding; pfam02817 1173027009488 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1173027009489 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027009490 active site residue [active] 1173027009491 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027009492 active site residue [active] 1173027009493 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027009494 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027009495 putative active site [active] 1173027009496 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173027009497 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1173027009498 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1173027009499 acyl-activating enzyme (AAE) consensus motif; other site 1173027009500 putative AMP binding site [chemical binding]; other site 1173027009501 putative active site [active] 1173027009502 putative CoA binding site [chemical binding]; other site 1173027009503 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1173027009504 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1173027009505 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1173027009506 nudix motif; other site 1173027009507 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1173027009508 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 1173027009509 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1173027009510 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1173027009511 homodimer interface [polypeptide binding]; other site 1173027009512 NADP binding site [chemical binding]; other site 1173027009513 substrate binding site [chemical binding]; other site 1173027009514 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173027009515 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173027009516 substrate binding pocket [chemical binding]; other site 1173027009517 chain length determination region; other site 1173027009518 substrate-Mg2+ binding site; other site 1173027009519 catalytic residues [active] 1173027009520 aspartate-rich region 1; other site 1173027009521 active site lid residues [active] 1173027009522 aspartate-rich region 2; other site 1173027009523 Divergent PAP2 family; Region: DUF212; pfam02681 1173027009524 RRXRR protein; Region: RRXRR; pfam14239 1173027009525 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 1173027009526 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1173027009527 active site 1173027009528 hydrophilic channel; other site 1173027009529 dimerization interface [polypeptide binding]; other site 1173027009530 catalytic residues [active] 1173027009531 active site lid [active] 1173027009532 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1173027009533 generic binding surface I; other site 1173027009534 generic binding surface II; other site 1173027009535 GUN4-like; Region: GUN4; pfam05419 1173027009536 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027009537 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027009538 structural tetrad; other site 1173027009539 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 1173027009540 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027009541 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173027009542 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1173027009543 Cl- selectivity filter; other site 1173027009544 Cl- binding residues [ion binding]; other site 1173027009545 pore gating glutamate residue; other site 1173027009546 dimer interface [polypeptide binding]; other site 1173027009547 H+/Cl- coupling transport residue; other site 1173027009548 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027009549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1173027009550 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173027009551 Ligand Binding Site [chemical binding]; other site 1173027009552 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027009553 Ligand Binding Site [chemical binding]; other site 1173027009554 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027009555 catalytic residues [active] 1173027009556 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1173027009557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027009558 motif II; other site 1173027009559 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027009560 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173027009561 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009562 putative active site [active] 1173027009563 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1173027009564 5'-3' exonuclease; Region: 53EXOc; smart00475 1173027009565 active site 1173027009566 metal binding site 1 [ion binding]; metal-binding site 1173027009567 putative 5' ssDNA interaction site; other site 1173027009568 metal binding site 3; metal-binding site 1173027009569 metal binding site 2 [ion binding]; metal-binding site 1173027009570 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1173027009571 putative DNA binding site [nucleotide binding]; other site 1173027009572 putative metal binding site [ion binding]; other site 1173027009573 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1173027009574 catalytic site [active] 1173027009575 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1173027009576 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1173027009577 active site 1173027009578 substrate binding site [chemical binding]; other site 1173027009579 catalytic site [active] 1173027009580 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1173027009581 active site 1173027009582 DNA binding site [nucleotide binding] 1173027009583 catalytic site [active] 1173027009584 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173027009585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027009586 Ligand Binding Site [chemical binding]; other site 1173027009587 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027009588 Ligand Binding Site [chemical binding]; other site 1173027009589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027009590 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173027009591 active site 1173027009592 metal binding site [ion binding]; metal-binding site 1173027009593 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1173027009594 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1173027009595 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1173027009596 Ligand binding site; other site 1173027009597 Putative Catalytic site; other site 1173027009598 DXD motif; other site 1173027009599 TPR repeat; Region: TPR_11; pfam13414 1173027009600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009601 binding surface 1173027009602 TPR motif; other site 1173027009603 TPR repeat; Region: TPR_11; pfam13414 1173027009604 TPR repeat; Region: TPR_11; pfam13414 1173027009605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009606 binding surface 1173027009607 TPR motif; other site 1173027009608 TPR repeat; Region: TPR_11; pfam13414 1173027009609 TPR repeat; Region: TPR_11; pfam13414 1173027009610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009611 binding surface 1173027009612 TPR motif; other site 1173027009613 TPR repeat; Region: TPR_11; pfam13414 1173027009614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009615 binding surface 1173027009616 TPR motif; other site 1173027009617 TPR repeat; Region: TPR_11; pfam13414 1173027009618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009619 binding surface 1173027009620 TPR motif; other site 1173027009621 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1173027009622 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1173027009623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027009624 catalytic residue [active] 1173027009625 Probable transposase; Region: OrfB_IS605; pfam01385 1173027009626 Probable transposase; Region: OrfB_IS605; pfam01385 1173027009627 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1173027009628 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1173027009629 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1173027009630 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027009631 allophycocyanin beta subunit; Region: apcB; CHL00088 1173027009632 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027009633 phycobillisome linker protein; Region: apcE; CHL00091 1173027009634 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027009635 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027009636 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027009637 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027009638 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027009639 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027009640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027009641 S-adenosylmethionine binding site [chemical binding]; other site 1173027009642 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009643 putative active site [active] 1173027009644 Rapsyn N-terminal myristoylation and linker region; Region: Rapsyn_N; pfam10579 1173027009645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009646 binding surface 1173027009647 TPR motif; other site 1173027009648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009651 TPR motif; other site 1173027009652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009653 binding surface 1173027009654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009655 binding surface 1173027009656 TPR motif; other site 1173027009657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009659 binding surface 1173027009660 TPR motif; other site 1173027009661 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009662 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009664 binding surface 1173027009665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009666 TPR motif; other site 1173027009667 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009669 TPR motif; other site 1173027009670 binding surface 1173027009671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009674 binding surface 1173027009675 TPR motif; other site 1173027009676 CHAT domain; Region: CHAT; pfam12770 1173027009677 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1173027009678 core domain interface [polypeptide binding]; other site 1173027009679 delta subunit interface [polypeptide binding]; other site 1173027009680 epsilon subunit interface [polypeptide binding]; other site 1173027009681 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 1173027009682 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173027009683 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1173027009684 beta subunit interaction interface [polypeptide binding]; other site 1173027009685 Walker A motif; other site 1173027009686 ATP binding site [chemical binding]; other site 1173027009687 Walker B motif; other site 1173027009688 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173027009689 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1173027009690 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1173027009691 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173027009692 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1173027009693 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1173027009694 ATP synthase CF0 C subunit; Region: atpH; CHL00061 1173027009695 ATP synthase CF0 A subunit; Region: atpI; CHL00046 1173027009696 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1173027009697 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1173027009698 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027009699 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027009700 catalytic loop [active] 1173027009701 iron binding site [ion binding]; other site 1173027009702 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027009703 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1173027009704 CAAX protease self-immunity; Region: Abi; pfam02517 1173027009705 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1173027009706 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1173027009707 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1173027009708 active site 1173027009709 substrate binding site [chemical binding]; other site 1173027009710 cosubstrate binding site; other site 1173027009711 catalytic site [active] 1173027009712 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 1173027009713 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 1173027009714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027009715 dimer interface [polypeptide binding]; other site 1173027009716 conserved gate region; other site 1173027009717 putative PBP binding loops; other site 1173027009718 ABC-ATPase subunit interface; other site 1173027009719 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027009720 ABC1 family; Region: ABC1; cl17513 1173027009721 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1173027009722 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173027009723 P loop; other site 1173027009724 Nucleotide binding site [chemical binding]; other site 1173027009725 DTAP/Switch II; other site 1173027009726 Switch I; other site 1173027009727 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173027009728 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173027009729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027009730 dimerization interface [polypeptide binding]; other site 1173027009731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009732 dimer interface [polypeptide binding]; other site 1173027009733 phosphorylation site [posttranslational modification] 1173027009734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009735 ATP binding site [chemical binding]; other site 1173027009736 Mg2+ binding site [ion binding]; other site 1173027009737 G-X-G motif; other site 1173027009738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027009739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009740 active site 1173027009741 phosphorylation site [posttranslational modification] 1173027009742 intermolecular recognition site; other site 1173027009743 dimerization interface [polypeptide binding]; other site 1173027009744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027009745 DNA binding site [nucleotide binding] 1173027009746 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009747 putative active site [active] 1173027009748 YcfA-like protein; Region: YcfA; pfam07927 1173027009749 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1173027009750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027009751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009752 active site 1173027009753 phosphorylation site [posttranslational modification] 1173027009754 intermolecular recognition site; other site 1173027009755 dimerization interface [polypeptide binding]; other site 1173027009756 PAS domain; Region: PAS_9; pfam13426 1173027009757 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173027009758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009759 PAS domain; Region: PAS_9; pfam13426 1173027009760 putative active site [active] 1173027009761 heme pocket [chemical binding]; other site 1173027009762 PAS fold; Region: PAS_4; pfam08448 1173027009763 PAS domain S-box; Region: sensory_box; TIGR00229 1173027009764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009765 putative active site [active] 1173027009766 heme pocket [chemical binding]; other site 1173027009767 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027009768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009769 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027009770 putative active site [active] 1173027009771 heme pocket [chemical binding]; other site 1173027009772 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027009773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009774 putative active site [active] 1173027009775 heme pocket [chemical binding]; other site 1173027009776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009777 putative active site [active] 1173027009778 heme pocket [chemical binding]; other site 1173027009779 PAS domain S-box; Region: sensory_box; TIGR00229 1173027009780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009781 putative active site [active] 1173027009782 heme pocket [chemical binding]; other site 1173027009783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009785 dimer interface [polypeptide binding]; other site 1173027009786 phosphorylation site [posttranslational modification] 1173027009787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009788 ATP binding site [chemical binding]; other site 1173027009789 Mg2+ binding site [ion binding]; other site 1173027009790 G-X-G motif; other site 1173027009791 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009793 active site 1173027009794 phosphorylation site [posttranslational modification] 1173027009795 intermolecular recognition site; other site 1173027009796 dimerization interface [polypeptide binding]; other site 1173027009797 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027009798 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027009799 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027009800 putative active site [active] 1173027009801 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027009802 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027009803 PQQ-like domain; Region: PQQ_2; pfam13360 1173027009804 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173027009805 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173027009806 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1173027009807 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173027009808 FMN binding site [chemical binding]; other site 1173027009809 active site 1173027009810 catalytic residues [active] 1173027009811 substrate binding site [chemical binding]; other site 1173027009812 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173027009813 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027009814 C-terminal domain interface [polypeptide binding]; other site 1173027009815 GSH binding site (G-site) [chemical binding]; other site 1173027009816 dimer interface [polypeptide binding]; other site 1173027009817 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173027009818 N-terminal domain interface [polypeptide binding]; other site 1173027009819 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1173027009820 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1173027009821 catalytic residues [active] 1173027009822 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1173027009823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1173027009824 molybdopterin cofactor binding site; other site 1173027009825 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1173027009826 molybdopterin cofactor binding site; other site 1173027009827 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1173027009828 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1173027009829 Zn binding site [ion binding]; other site 1173027009830 Predicted coiled-coil protein (DUF2205); Region: DUF2205; pfam10224 1173027009831 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009833 active site 1173027009834 phosphorylation site [posttranslational modification] 1173027009835 intermolecular recognition site; other site 1173027009836 dimerization interface [polypeptide binding]; other site 1173027009837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009839 dimer interface [polypeptide binding]; other site 1173027009840 phosphorylation site [posttranslational modification] 1173027009841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009842 ATP binding site [chemical binding]; other site 1173027009843 Mg2+ binding site [ion binding]; other site 1173027009844 G-X-G motif; other site 1173027009845 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009847 active site 1173027009848 phosphorylation site [posttranslational modification] 1173027009849 intermolecular recognition site; other site 1173027009850 dimerization interface [polypeptide binding]; other site 1173027009851 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027009852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009853 active site 1173027009854 phosphorylation site [posttranslational modification] 1173027009855 intermolecular recognition site; other site 1173027009856 dimerization interface [polypeptide binding]; other site 1173027009857 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027009858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009859 active site 1173027009860 phosphorylation site [posttranslational modification] 1173027009861 intermolecular recognition site; other site 1173027009862 dimerization interface [polypeptide binding]; other site 1173027009863 PAS fold; Region: PAS_4; pfam08448 1173027009864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009865 putative active site [active] 1173027009866 heme pocket [chemical binding]; other site 1173027009867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009868 dimer interface [polypeptide binding]; other site 1173027009869 phosphorylation site [posttranslational modification] 1173027009870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009872 ATP binding site [chemical binding]; other site 1173027009873 Mg2+ binding site [ion binding]; other site 1173027009874 G-X-G motif; other site 1173027009875 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027009876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009877 binding surface 1173027009878 TPR motif; other site 1173027009879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009880 binding surface 1173027009881 TPR motif; other site 1173027009882 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1173027009883 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1173027009884 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1173027009885 active site 1173027009886 dimer interface [polypeptide binding]; other site 1173027009887 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1173027009888 dimer interface [polypeptide binding]; other site 1173027009889 active site 1173027009890 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027009891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027009892 active site 1173027009893 phosphorylation site [posttranslational modification] 1173027009894 intermolecular recognition site; other site 1173027009895 dimerization interface [polypeptide binding]; other site 1173027009896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027009897 DNA binding residues [nucleotide binding] 1173027009898 dimerization interface [polypeptide binding]; other site 1173027009899 MASE1; Region: MASE1; pfam05231 1173027009900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027009901 PAS fold; Region: PAS_3; pfam08447 1173027009902 putative active site [active] 1173027009903 heme pocket [chemical binding]; other site 1173027009904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027009905 GAF domain; Region: GAF; pfam01590 1173027009906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027009907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027009908 dimer interface [polypeptide binding]; other site 1173027009909 phosphorylation site [posttranslational modification] 1173027009910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027009911 ATP binding site [chemical binding]; other site 1173027009912 Mg2+ binding site [ion binding]; other site 1173027009913 G-X-G motif; other site 1173027009914 Cupin domain; Region: Cupin_2; cl17218 1173027009915 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027009916 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027009917 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027009918 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027009919 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027009920 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027009921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009923 TPR motif; other site 1173027009924 binding surface 1173027009925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027009926 TPR motif; other site 1173027009927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027009928 binding surface 1173027009929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027009930 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027009931 TIR domain; Region: TIR_2; pfam13676 1173027009932 TIR domain; Region: TIR_2; pfam13676 1173027009933 TIR domain; Region: TIR_2; pfam13676 1173027009934 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027009935 CHASE2 domain; Region: CHASE2; pfam05226 1173027009936 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027009937 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009938 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009940 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027009944 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1173027009945 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1173027009946 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173027009947 putative active site [active] 1173027009948 putative NTP binding site [chemical binding]; other site 1173027009949 putative nucleic acid binding site [nucleotide binding]; other site 1173027009950 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1173027009951 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027009952 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027009953 active site 1173027009954 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1173027009955 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1173027009956 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173027009957 putative NTP binding site [chemical binding]; other site 1173027009958 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 1173027009959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027009960 Probable transposase; Region: OrfB_IS605; pfam01385 1173027009961 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027009962 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1173027009963 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1173027009964 RNA binding site [nucleotide binding]; other site 1173027009965 active site 1173027009966 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1173027009967 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173027009968 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027009969 catalytic triad [active] 1173027009970 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173027009971 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173027009972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027009973 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1173027009974 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173027009975 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173027009976 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1173027009977 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1173027009978 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1173027009979 Catalytic site [active] 1173027009980 muropeptide transporter; Validated; Region: ampG; cl17669 1173027009981 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1173027009982 Na binding site [ion binding]; other site 1173027009983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027009984 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173027009985 Coenzyme A binding pocket [chemical binding]; other site 1173027009986 HEAT repeats; Region: HEAT_2; pfam13646 1173027009987 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027009988 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027009989 HEAT repeats; Region: HEAT_2; pfam13646 1173027009990 HEAT repeats; Region: HEAT_2; pfam13646 1173027009991 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1173027009992 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1173027009993 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027009994 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027009995 ligand binding site [chemical binding]; other site 1173027009996 flexible hinge region; other site 1173027009997 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1173027009998 cell division topological specificity factor MinE; Provisional; Region: PRK13988 1173027009999 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1173027010000 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1173027010001 Switch I; other site 1173027010002 Switch II; other site 1173027010003 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1173027010004 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1173027010005 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027010006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010007 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1173027010009 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 1173027010010 HEAT repeats; Region: HEAT_2; pfam13646 1173027010011 HEAT repeats; Region: HEAT_2; pfam13646 1173027010012 HEAT repeats; Region: HEAT_2; pfam13646 1173027010013 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1173027010014 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1173027010015 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027010016 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027010017 ligand binding site [chemical binding]; other site 1173027010018 flexible hinge region; other site 1173027010019 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027010020 putative switch regulator; other site 1173027010021 non-specific DNA interactions [nucleotide binding]; other site 1173027010022 DNA binding site [nucleotide binding] 1173027010023 sequence specific DNA binding site [nucleotide binding]; other site 1173027010024 putative cAMP binding site [chemical binding]; other site 1173027010025 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1173027010026 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1173027010027 AAA ATPase domain; Region: AAA_16; pfam13191 1173027010028 NB-ARC domain; Region: NB-ARC; pfam00931 1173027010029 WD40 repeats; Region: WD40; smart00320 1173027010030 WD40 repeats; Region: WD40; smart00320 1173027010031 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027010032 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027010033 structural tetrad; other site 1173027010034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027010035 structural tetrad; other site 1173027010036 WD domain, G-beta repeat; Region: WD40; pfam00400 1173027010037 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1173027010038 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1173027010039 putative ligand binding site [chemical binding]; other site 1173027010040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027010041 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1173027010042 TM-ABC transporter signature motif; other site 1173027010043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173027010044 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1173027010045 TM-ABC transporter signature motif; other site 1173027010046 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1173027010047 Isochorismatase family; Region: Isochorismatase; pfam00857 1173027010048 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173027010049 catalytic triad [active] 1173027010050 conserved cis-peptide bond; other site 1173027010051 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1173027010052 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1173027010053 Walker A/P-loop; other site 1173027010054 ATP binding site [chemical binding]; other site 1173027010055 Q-loop/lid; other site 1173027010056 ABC transporter signature motif; other site 1173027010057 Walker B; other site 1173027010058 D-loop; other site 1173027010059 H-loop/switch region; other site 1173027010060 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1173027010061 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173027010062 Isochorismatase family; Region: Isochorismatase; pfam00857 1173027010063 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173027010064 catalytic triad [active] 1173027010065 conserved cis-peptide bond; other site 1173027010066 S-layer homology domain; Region: SLH; pfam00395 1173027010067 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027010068 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1173027010069 Coenzyme A binding pocket [chemical binding]; other site 1173027010070 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 1173027010071 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027010072 nudix motif; other site 1173027010073 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173027010074 active site 1173027010075 catalytic residues [active] 1173027010076 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1173027010077 homooctamer interface [polypeptide binding]; other site 1173027010078 active site 1173027010079 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1173027010080 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027010081 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1173027010082 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1173027010083 DXD motif; other site 1173027010084 PilZ domain; Region: PilZ; pfam07238 1173027010085 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173027010086 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173027010087 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1173027010088 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1173027010089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173027010090 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1173027010091 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 1173027010092 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 1173027010093 CRISPR type I-D/CYANO-associated protein Csc2; Region: cas_Csc2; TIGR03157 1173027010094 WYL domain; Region: WYL; pfam13280 1173027010095 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027010096 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027010097 active site 1173027010098 ATP binding site [chemical binding]; other site 1173027010099 substrate binding site [chemical binding]; other site 1173027010100 activation loop (A-loop); other site 1173027010101 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027010102 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1173027010103 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173027010104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027010105 catalytic residue [active] 1173027010106 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173027010107 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173027010108 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173027010109 catalytic site [active] 1173027010110 putative active site [active] 1173027010111 putative substrate binding site [chemical binding]; other site 1173027010112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027010113 active site residue [active] 1173027010114 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1173027010115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010117 dimer interface [polypeptide binding]; other site 1173027010118 phosphorylation site [posttranslational modification] 1173027010119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010120 ATP binding site [chemical binding]; other site 1173027010121 Mg2+ binding site [ion binding]; other site 1173027010122 G-X-G motif; other site 1173027010123 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010125 active site 1173027010126 phosphorylation site [posttranslational modification] 1173027010127 intermolecular recognition site; other site 1173027010128 dimerization interface [polypeptide binding]; other site 1173027010129 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027010130 cyclase homology domain; Region: CHD; cd07302 1173027010131 nucleotidyl binding site; other site 1173027010132 metal binding site [ion binding]; metal-binding site 1173027010133 dimer interface [polypeptide binding]; other site 1173027010134 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173027010135 active site residue [active] 1173027010136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173027010137 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173027010138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027010139 dimer interface [polypeptide binding]; other site 1173027010140 conserved gate region; other site 1173027010141 putative PBP binding loops; other site 1173027010142 ABC-ATPase subunit interface; other site 1173027010143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027010144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027010145 ABC-ATPase subunit interface; other site 1173027010146 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173027010147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027010148 Walker A/P-loop; other site 1173027010149 ATP binding site [chemical binding]; other site 1173027010150 Q-loop/lid; other site 1173027010151 ABC transporter signature motif; other site 1173027010152 Walker B; other site 1173027010153 D-loop; other site 1173027010154 H-loop/switch region; other site 1173027010155 TOBE domain; Region: TOBE_2; pfam08402 1173027010156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010157 PAS fold; Region: PAS_3; pfam08447 1173027010158 putative active site [active] 1173027010159 heme pocket [chemical binding]; other site 1173027010160 PAS fold; Region: PAS_4; pfam08448 1173027010161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173027010162 putative active site [active] 1173027010163 heme pocket [chemical binding]; other site 1173027010164 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010165 PAS domain; Region: PAS_8; pfam13188 1173027010166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010167 putative active site [active] 1173027010168 heme pocket [chemical binding]; other site 1173027010169 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 1173027010170 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010171 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027010172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010174 dimer interface [polypeptide binding]; other site 1173027010175 phosphorylation site [posttranslational modification] 1173027010176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010177 ATP binding site [chemical binding]; other site 1173027010178 Mg2+ binding site [ion binding]; other site 1173027010179 G-X-G motif; other site 1173027010180 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010182 active site 1173027010183 phosphorylation site [posttranslational modification] 1173027010184 intermolecular recognition site; other site 1173027010185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010186 dimerization interface [polypeptide binding]; other site 1173027010187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010188 dimer interface [polypeptide binding]; other site 1173027010189 phosphorylation site [posttranslational modification] 1173027010190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010191 ATP binding site [chemical binding]; other site 1173027010192 Mg2+ binding site [ion binding]; other site 1173027010193 G-X-G motif; other site 1173027010194 PAS fold; Region: PAS_4; pfam08448 1173027010195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010196 PAS fold; Region: PAS_3; pfam08447 1173027010197 putative active site [active] 1173027010198 heme pocket [chemical binding]; other site 1173027010199 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010201 putative active site [active] 1173027010202 heme pocket [chemical binding]; other site 1173027010203 PAS fold; Region: PAS_3; pfam08447 1173027010204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010205 heme pocket [chemical binding]; other site 1173027010206 putative active site [active] 1173027010207 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010209 putative active site [active] 1173027010210 heme pocket [chemical binding]; other site 1173027010211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010213 dimer interface [polypeptide binding]; other site 1173027010214 phosphorylation site [posttranslational modification] 1173027010215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010216 ATP binding site [chemical binding]; other site 1173027010217 Mg2+ binding site [ion binding]; other site 1173027010218 G-X-G motif; other site 1173027010219 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010221 active site 1173027010222 phosphorylation site [posttranslational modification] 1173027010223 intermolecular recognition site; other site 1173027010224 dimerization interface [polypeptide binding]; other site 1173027010225 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027010226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010227 active site 1173027010228 phosphorylation site [posttranslational modification] 1173027010229 intermolecular recognition site; other site 1173027010230 dimerization interface [polypeptide binding]; other site 1173027010231 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010233 active site 1173027010234 phosphorylation site [posttranslational modification] 1173027010235 intermolecular recognition site; other site 1173027010236 dimerization interface [polypeptide binding]; other site 1173027010237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010239 dimer interface [polypeptide binding]; other site 1173027010240 phosphorylation site [posttranslational modification] 1173027010241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010242 ATP binding site [chemical binding]; other site 1173027010243 Mg2+ binding site [ion binding]; other site 1173027010244 G-X-G motif; other site 1173027010245 S-layer homology domain; Region: SLH; pfam00395 1173027010246 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027010247 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 1173027010248 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173027010249 active site residue [active] 1173027010250 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027010251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027010252 phosphopeptide binding site; other site 1173027010253 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027010254 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010255 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027010256 cyclase homology domain; Region: CHD; cd07302 1173027010257 nucleotidyl binding site; other site 1173027010258 metal binding site [ion binding]; metal-binding site 1173027010259 dimer interface [polypeptide binding]; other site 1173027010260 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027010261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010264 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027010265 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010266 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027010267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010268 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010270 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010271 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027010272 nitrilase; Region: PLN02798 1173027010273 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1173027010274 putative active site [active] 1173027010275 catalytic triad [active] 1173027010276 dimer interface [polypeptide binding]; other site 1173027010277 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1173027010278 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173027010279 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1173027010280 NlpC/P60 family; Region: NLPC_P60; pfam00877 1173027010281 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027010282 putative active site [active] 1173027010283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027010284 non-specific DNA binding site [nucleotide binding]; other site 1173027010285 salt bridge; other site 1173027010286 sequence-specific DNA binding site [nucleotide binding]; other site 1173027010287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027010288 non-specific DNA binding site [nucleotide binding]; other site 1173027010289 salt bridge; other site 1173027010290 sequence-specific DNA binding site [nucleotide binding]; other site 1173027010291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173027010292 non-specific DNA binding site [nucleotide binding]; other site 1173027010293 salt bridge; other site 1173027010294 sequence-specific DNA binding site [nucleotide binding]; other site 1173027010295 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173027010296 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173027010297 Ligand binding site; other site 1173027010298 Putative Catalytic site; other site 1173027010299 DXD motif; other site 1173027010300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027010301 putative substrate translocation pore; other site 1173027010302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027010303 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027010304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027010305 active site 1173027010306 ATP binding site [chemical binding]; other site 1173027010307 substrate binding site [chemical binding]; other site 1173027010308 activation loop (A-loop); other site 1173027010309 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010311 active site 1173027010312 phosphorylation site [posttranslational modification] 1173027010313 intermolecular recognition site; other site 1173027010314 dimerization interface [polypeptide binding]; other site 1173027010315 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027010316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010317 putative active site [active] 1173027010318 heme pocket [chemical binding]; other site 1173027010319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010320 dimer interface [polypeptide binding]; other site 1173027010321 phosphorylation site [posttranslational modification] 1173027010322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010323 ATP binding site [chemical binding]; other site 1173027010324 Mg2+ binding site [ion binding]; other site 1173027010325 G-X-G motif; other site 1173027010326 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010328 active site 1173027010329 phosphorylation site [posttranslational modification] 1173027010330 intermolecular recognition site; other site 1173027010331 dimerization interface [polypeptide binding]; other site 1173027010332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027010333 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027010334 active site 1173027010335 ATP binding site [chemical binding]; other site 1173027010336 substrate binding site [chemical binding]; other site 1173027010337 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027010338 substrate binding site [chemical binding]; other site 1173027010339 activation loop (A-loop); other site 1173027010340 activation loop (A-loop); other site 1173027010341 AAA ATPase domain; Region: AAA_16; pfam13191 1173027010342 Predicted ATPase [General function prediction only]; Region: COG3899 1173027010343 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010344 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027010345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010347 dimer interface [polypeptide binding]; other site 1173027010348 phosphorylation site [posttranslational modification] 1173027010349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010350 ATP binding site [chemical binding]; other site 1173027010351 Mg2+ binding site [ion binding]; other site 1173027010352 G-X-G motif; other site 1173027010353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027010354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010355 active site 1173027010356 phosphorylation site [posttranslational modification] 1173027010357 intermolecular recognition site; other site 1173027010358 dimerization interface [polypeptide binding]; other site 1173027010359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027010360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027010361 putative substrate translocation pore; other site 1173027010362 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1173027010363 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1173027010364 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1173027010365 ATP-sulfurylase; Region: ATPS; cd00517 1173027010366 active site 1173027010367 HXXH motif; other site 1173027010368 flexible loop; other site 1173027010369 Caspase domain; Region: Peptidase_C14; pfam00656 1173027010370 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173027010371 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1173027010372 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027010373 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1173027010374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027010375 putative active site [active] 1173027010376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010377 TPR motif; other site 1173027010378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010379 binding surface 1173027010380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010382 TPR motif; other site 1173027010383 binding surface 1173027010384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010386 binding surface 1173027010387 TPR motif; other site 1173027010388 TPR repeat; Region: TPR_11; pfam13414 1173027010389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010390 binding surface 1173027010391 TPR motif; other site 1173027010392 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010394 binding surface 1173027010395 TPR repeat; Region: TPR_11; pfam13414 1173027010396 TPR motif; other site 1173027010397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010398 TPR motif; other site 1173027010399 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010400 binding surface 1173027010401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010403 binding surface 1173027010404 TPR motif; other site 1173027010405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010409 binding surface 1173027010410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010411 TPR motif; other site 1173027010412 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010413 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010415 binding surface 1173027010416 TPR motif; other site 1173027010417 CHAT domain; Region: CHAT; cl17868 1173027010418 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173027010419 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1173027010420 S-layer homology domain; Region: SLH; pfam00395 1173027010421 S-layer homology domain; Region: SLH; pfam00395 1173027010422 S-layer homology domain; Region: SLH; pfam00395 1173027010423 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 1173027010424 TPR repeat; Region: TPR_11; pfam13414 1173027010425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010426 binding surface 1173027010427 TPR motif; other site 1173027010428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010430 binding surface 1173027010431 TPR motif; other site 1173027010432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010434 binding surface 1173027010435 TPR motif; other site 1173027010436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027010438 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1173027010439 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1173027010440 catalytic triad [active] 1173027010441 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027010442 putative active site [active] 1173027010443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010445 binding surface 1173027010446 TPR motif; other site 1173027010447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010448 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010452 TPR motif; other site 1173027010453 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010454 binding surface 1173027010455 CHAT domain; Region: CHAT; cl17868 1173027010456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010458 TPR motif; other site 1173027010459 binding surface 1173027010460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010464 binding surface 1173027010465 TPR motif; other site 1173027010466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027010467 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027010468 putative active site [active] 1173027010469 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1173027010470 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1173027010471 putative hydrophobic ligand binding site [chemical binding]; other site 1173027010472 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1173027010473 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1173027010474 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1173027010475 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1173027010476 putative NAD(P) binding site [chemical binding]; other site 1173027010477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173027010478 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173027010479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027010480 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173027010481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027010482 motif II; other site 1173027010483 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173027010484 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 1173027010485 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1173027010486 active site 1173027010487 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010488 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027010489 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010490 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1173027010491 Sm and related proteins; Region: Sm_like; cl00259 1173027010492 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1173027010493 putative oligomer interface [polypeptide binding]; other site 1173027010494 putative RNA binding site [nucleotide binding]; other site 1173027010495 NusA N-terminal domain; Region: NusA_N; pfam08529 1173027010496 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1173027010497 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1173027010498 RNA binding site [nucleotide binding]; other site 1173027010499 homodimer interface [polypeptide binding]; other site 1173027010500 NusA-like KH domain; Region: KH_5; pfam13184 1173027010501 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1173027010502 G-X-X-G motif; other site 1173027010503 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1173027010504 putative RNA binding cleft [nucleotide binding]; other site 1173027010505 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173027010506 translation initiation factor IF-2; Region: IF-2; TIGR00487 1173027010507 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173027010508 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1173027010509 G1 box; other site 1173027010510 putative GEF interaction site [polypeptide binding]; other site 1173027010511 GTP/Mg2+ binding site [chemical binding]; other site 1173027010512 Switch I region; other site 1173027010513 G2 box; other site 1173027010514 G3 box; other site 1173027010515 Switch II region; other site 1173027010516 G4 box; other site 1173027010517 G5 box; other site 1173027010518 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1173027010519 Translation-initiation factor 2; Region: IF-2; pfam11987 1173027010520 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1173027010521 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173027010522 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027010523 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027010524 CHASE2 domain; Region: CHASE2; pfam05226 1173027010525 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027010526 cyclase homology domain; Region: CHD; cd07302 1173027010527 nucleotidyl binding site; other site 1173027010528 metal binding site [ion binding]; metal-binding site 1173027010529 dimer interface [polypeptide binding]; other site 1173027010530 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027010531 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027010532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027010533 Stage II sporulation protein; Region: SpoIID; pfam08486 1173027010534 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1173027010535 ribonuclease Z; Region: RNase_Z; TIGR02651 1173027010536 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1173027010537 homotrimer interface [polypeptide binding]; other site 1173027010538 Walker A motif; other site 1173027010539 GTP binding site [chemical binding]; other site 1173027010540 Walker B motif; other site 1173027010541 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027010542 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173027010543 putative metal binding site; other site 1173027010544 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173027010545 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1173027010546 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173027010547 ligand-binding site [chemical binding]; other site 1173027010548 Homeodomain-like domain; Region: HTH_23; pfam13384 1173027010549 Winged helix-turn helix; Region: HTH_29; pfam13551 1173027010550 Integrase core domain; Region: rve; pfam00665 1173027010551 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027010552 AIPR protein; Region: AIPR; pfam10592 1173027010553 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1173027010554 Z1 domain; Region: Z1; pfam10593 1173027010555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010556 ATP binding site [chemical binding]; other site 1173027010557 Mg2+ binding site [ion binding]; other site 1173027010558 G-X-G motif; other site 1173027010559 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027010560 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027010561 cofactor binding site; other site 1173027010562 DNA binding site [nucleotide binding] 1173027010563 substrate interaction site [chemical binding]; other site 1173027010564 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027010565 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173027010566 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027010567 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1173027010568 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027010569 lipoyl synthase; Provisional; Region: PRK05481 1173027010570 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1173027010571 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173027010572 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1173027010573 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 1173027010574 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173027010575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027010576 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027010577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027010578 DNA binding residues [nucleotide binding] 1173027010579 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027010580 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010581 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010583 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027010584 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010585 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027010586 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010587 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027010588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027010589 putative DNA binding site [nucleotide binding]; other site 1173027010590 putative Zn2+ binding site [ion binding]; other site 1173027010591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010592 binding surface 1173027010593 TPR motif; other site 1173027010594 TPR repeat; Region: TPR_11; pfam13414 1173027010595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010596 binding surface 1173027010597 TPR motif; other site 1173027010598 TPR repeat; Region: TPR_11; pfam13414 1173027010599 TPR repeat; Region: TPR_11; pfam13414 1173027010600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010601 binding surface 1173027010602 TPR motif; other site 1173027010603 TPR repeat; Region: TPR_11; pfam13414 1173027010604 TPR repeat; Region: TPR_11; pfam13414 1173027010605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027010606 binding surface 1173027010607 TPR motif; other site 1173027010608 TPR repeat; Region: TPR_11; pfam13414 1173027010609 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1173027010610 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1173027010611 Lamin Tail Domain; Region: LTD; pfam00932 1173027010612 S-layer homology domain; Region: SLH; pfam00395 1173027010613 S-layer homology domain; Region: SLH; pfam00395 1173027010614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173027010615 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027010616 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 1173027010617 ADP-ribose binding site [chemical binding]; other site 1173027010618 putative active site [active] 1173027010619 dimer interface [polypeptide binding]; other site 1173027010620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173027010621 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173027010622 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1173027010623 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1173027010624 active site 1173027010625 homodimer interface [polypeptide binding]; other site 1173027010626 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173027010627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027010628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010629 active site 1173027010630 phosphorylation site [posttranslational modification] 1173027010631 intermolecular recognition site; other site 1173027010632 dimerization interface [polypeptide binding]; other site 1173027010633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027010634 DNA binding site [nucleotide binding] 1173027010635 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1173027010636 HAMP domain; Region: HAMP; pfam00672 1173027010637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010638 dimer interface [polypeptide binding]; other site 1173027010639 phosphorylation site [posttranslational modification] 1173027010640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010641 ATP binding site [chemical binding]; other site 1173027010642 Mg2+ binding site [ion binding]; other site 1173027010643 G-X-G motif; other site 1173027010644 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173027010645 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173027010646 Catalytic site [active] 1173027010647 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173027010648 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173027010649 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173027010650 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173027010651 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1173027010652 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 1173027010653 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1173027010654 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173027010655 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1173027010656 homodimer interface [polypeptide binding]; other site 1173027010657 substrate-cofactor binding pocket; other site 1173027010658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027010659 catalytic residue [active] 1173027010660 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027010661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010662 active site 1173027010663 phosphorylation site [posttranslational modification] 1173027010664 intermolecular recognition site; other site 1173027010665 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027010666 dimerization interface [polypeptide binding]; other site 1173027010667 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010669 dimer interface [polypeptide binding]; other site 1173027010670 phosphorylation site [posttranslational modification] 1173027010671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010672 ATP binding site [chemical binding]; other site 1173027010673 Mg2+ binding site [ion binding]; other site 1173027010674 G-X-G motif; other site 1173027010675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010677 active site 1173027010678 phosphorylation site [posttranslational modification] 1173027010679 intermolecular recognition site; other site 1173027010680 dimerization interface [polypeptide binding]; other site 1173027010681 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027010682 putative binding surface; other site 1173027010683 active site 1173027010684 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173027010685 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1173027010686 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1173027010687 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173027010688 anti sigma factor interaction site; other site 1173027010689 regulatory phosphorylation site [posttranslational modification]; other site 1173027010690 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173027010691 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173027010692 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173027010693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173027010694 ATP binding site [chemical binding]; other site 1173027010695 Mg2+ binding site [ion binding]; other site 1173027010696 G-X-G motif; other site 1173027010697 putative glycosyl transferase; Provisional; Region: PRK10307 1173027010698 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173027010699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027010700 Zn2+ binding site [ion binding]; other site 1173027010701 Mg2+ binding site [ion binding]; other site 1173027010702 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1173027010703 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1173027010704 L-asparaginase II; Region: Asparaginase_II; cl01842 1173027010705 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1173027010706 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173027010707 HIGH motif; other site 1173027010708 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173027010709 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173027010710 active site 1173027010711 KMSKS motif; other site 1173027010712 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1173027010713 tRNA binding surface [nucleotide binding]; other site 1173027010714 anticodon binding site; other site 1173027010715 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173027010716 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173027010717 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173027010718 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1173027010719 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1173027010720 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1173027010721 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027010722 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1173027010723 amidase catalytic site [active] 1173027010724 Zn binding residues [ion binding]; other site 1173027010725 substrate binding site [chemical binding]; other site 1173027010726 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173027010727 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027010728 active site 1173027010729 NTP binding site [chemical binding]; other site 1173027010730 metal binding triad [ion binding]; metal-binding site 1173027010731 antibiotic binding site [chemical binding]; other site 1173027010732 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027010733 putative active site [active] 1173027010734 magnesium chelatase subunit H; Provisional; Region: PLN03241 1173027010735 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027010736 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173027010737 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173027010738 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173027010739 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173027010740 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1173027010741 putative heme binding pocket [chemical binding]; other site 1173027010742 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1173027010743 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1173027010744 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027010745 3D domain; Region: 3D; pfam06725 1173027010746 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1173027010747 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027010748 active site 1173027010749 metal binding site [ion binding]; metal-binding site 1173027010750 XisH protein; Region: XisH; pfam08814 1173027010751 XisI protein; Region: XisI; pfam08869 1173027010752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1173027010753 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027010754 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1173027010755 putative acyl-acceptor binding pocket; other site 1173027010756 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1173027010757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027010758 active site 1173027010759 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173027010760 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1173027010761 GTP binding site; other site 1173027010762 GAF domain; Region: GAF; pfam01590 1173027010763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010764 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010766 putative active site [active] 1173027010767 heme pocket [chemical binding]; other site 1173027010768 PAS domain; Region: PAS; smart00091 1173027010769 PAS fold; Region: PAS_7; pfam12860 1173027010770 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010771 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027010772 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027010773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027010774 metal binding site [ion binding]; metal-binding site 1173027010775 active site 1173027010776 I-site; other site 1173027010777 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1173027010778 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1173027010779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010780 dimer interface [polypeptide binding]; other site 1173027010781 phosphorylation site [posttranslational modification] 1173027010782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010783 ATP binding site [chemical binding]; other site 1173027010784 Mg2+ binding site [ion binding]; other site 1173027010785 G-X-G motif; other site 1173027010786 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 1173027010787 PB1 interaction surface [polypeptide binding]; other site 1173027010788 PB1 interaction surface [polypeptide binding]; other site 1173027010789 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1173027010790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027010791 motif II; other site 1173027010792 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173027010793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173027010794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027010795 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173027010796 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173027010797 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173027010798 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027010799 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1173027010800 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027010801 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027010802 active site 1173027010803 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 1173027010804 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173027010805 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027010806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027010807 P-loop; other site 1173027010808 Magnesium ion binding site [ion binding]; other site 1173027010809 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027010810 Magnesium ion binding site [ion binding]; other site 1173027010811 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173027010812 catalytic site [active] 1173027010813 putative active site [active] 1173027010814 putative substrate binding site [chemical binding]; other site 1173027010815 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1173027010816 Predicted permease [General function prediction only]; Region: COG2985 1173027010817 TrkA-C domain; Region: TrkA_C; pfam02080 1173027010818 TrkA-C domain; Region: TrkA_C; pfam02080 1173027010819 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1173027010820 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1173027010821 PLD-like domain; Region: PLDc_2; pfam13091 1173027010822 putative active site [active] 1173027010823 catalytic site [active] 1173027010824 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1173027010825 PLD-like domain; Region: PLDc_2; pfam13091 1173027010826 putative active site [active] 1173027010827 catalytic site [active] 1173027010828 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173027010829 Helix-hairpin-helix motif; Region: HHH; pfam00633 1173027010830 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173027010831 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173027010832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027010833 catalytic residue [active] 1173027010834 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1173027010835 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1173027010836 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1173027010837 PAS domain S-box; Region: sensory_box; TIGR00229 1173027010838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010839 putative active site [active] 1173027010840 heme pocket [chemical binding]; other site 1173027010841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010842 PAS domain; Region: PAS_9; pfam13426 1173027010843 putative active site [active] 1173027010844 heme pocket [chemical binding]; other site 1173027010845 Heme NO binding associated; Region: HNOBA; pfam07701 1173027010846 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027010847 cyclase homology domain; Region: CHD; cd07302 1173027010848 nucleotidyl binding site; other site 1173027010849 metal binding site [ion binding]; metal-binding site 1173027010850 dimer interface [polypeptide binding]; other site 1173027010851 patatin-related protein; Region: TIGR03607 1173027010852 Patatin-like phospholipase; Region: Patatin; pfam01734 1173027010853 nucleophile elbow; other site 1173027010854 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1173027010855 CheB methylesterase; Region: CheB_methylest; pfam01339 1173027010856 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173027010857 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173027010858 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173027010859 PAS fold; Region: PAS; pfam00989 1173027010860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010861 putative active site [active] 1173027010862 heme pocket [chemical binding]; other site 1173027010863 PAS domain; Region: PAS_9; pfam13426 1173027010864 Caspase domain; Region: Peptidase_C14; pfam00656 1173027010865 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173027010866 arginine decarboxylase; Provisional; Region: PRK05354 1173027010867 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1173027010868 dimer interface [polypeptide binding]; other site 1173027010869 active site 1173027010870 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173027010871 catalytic residues [active] 1173027010872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173027010873 CHAT domain; Region: CHAT; pfam12770 1173027010874 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1173027010875 active site 1173027010876 catalytic triad [active] 1173027010877 ferredoxin-sulfite reductase; Region: sir; TIGR02042 1173027010878 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027010879 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027010880 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173027010881 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027010882 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173027010883 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173027010884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173027010885 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173027010886 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173027010887 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173027010888 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173027010889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027010890 Walker A/P-loop; other site 1173027010891 ATP binding site [chemical binding]; other site 1173027010892 Q-loop/lid; other site 1173027010893 ABC transporter signature motif; other site 1173027010894 Walker B; other site 1173027010895 D-loop; other site 1173027010896 H-loop/switch region; other site 1173027010897 TOBE domain; Region: TOBE_2; pfam08402 1173027010898 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173027010899 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173027010900 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173027010901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027010902 dimer interface [polypeptide binding]; other site 1173027010903 conserved gate region; other site 1173027010904 putative PBP binding loops; other site 1173027010905 ABC-ATPase subunit interface; other site 1173027010906 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1173027010907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027010908 dimer interface [polypeptide binding]; other site 1173027010909 conserved gate region; other site 1173027010910 putative PBP binding loops; other site 1173027010911 ABC-ATPase subunit interface; other site 1173027010912 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027010913 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027010914 putative active site [active] 1173027010915 heme pocket [chemical binding]; other site 1173027010916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010917 dimer interface [polypeptide binding]; other site 1173027010918 phosphorylation site [posttranslational modification] 1173027010919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010920 ATP binding site [chemical binding]; other site 1173027010921 Mg2+ binding site [ion binding]; other site 1173027010922 G-X-G motif; other site 1173027010923 Cache domain; Region: Cache_1; pfam02743 1173027010924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027010925 dimerization interface [polypeptide binding]; other site 1173027010926 cyclase homology domain; Region: CHD; cd07302 1173027010927 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027010928 nucleotidyl binding site; other site 1173027010929 metal binding site [ion binding]; metal-binding site 1173027010930 dimer interface [polypeptide binding]; other site 1173027010931 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1173027010932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027010933 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1173027010934 GNT-I family; Region: GNT-I; pfam03071 1173027010935 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1173027010936 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173027010937 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1173027010938 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173027010939 O-Antigen ligase; Region: Wzy_C; pfam04932 1173027010940 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1173027010941 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1173027010942 phosphodiesterase YaeI; Provisional; Region: PRK11340 1173027010943 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173027010944 putative active site [active] 1173027010945 putative metal binding site [ion binding]; other site 1173027010946 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027010947 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027010948 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1173027010949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027010950 Coenzyme A binding pocket [chemical binding]; other site 1173027010951 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010953 active site 1173027010954 phosphorylation site [posttranslational modification] 1173027010955 intermolecular recognition site; other site 1173027010956 dimerization interface [polypeptide binding]; other site 1173027010957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027010958 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027010959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027010960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027010961 dimer interface [polypeptide binding]; other site 1173027010962 phosphorylation site [posttranslational modification] 1173027010963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027010964 ATP binding site [chemical binding]; other site 1173027010965 Mg2+ binding site [ion binding]; other site 1173027010966 G-X-G motif; other site 1173027010967 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027010968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027010969 active site 1173027010970 phosphorylation site [posttranslational modification] 1173027010971 intermolecular recognition site; other site 1173027010972 dimerization interface [polypeptide binding]; other site 1173027010973 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027010974 cyclase homology domain; Region: CHD; cd07302 1173027010975 nucleotidyl binding site; other site 1173027010976 metal binding site [ion binding]; metal-binding site 1173027010977 dimer interface [polypeptide binding]; other site 1173027010978 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 1173027010979 GUN4-like; Region: GUN4; pfam05419 1173027010980 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1173027010981 heme binding pocket [chemical binding]; other site 1173027010982 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 1173027010983 substrate binding site [chemical binding]; other site 1173027010984 homodimer interface [polypeptide binding]; other site 1173027010985 heme binding site [chemical binding]; other site 1173027010986 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1173027010987 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173027010988 Ycf39; Provisional; Region: ycf39; CHL00194 1173027010989 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173027010990 NAD(P) binding site [chemical binding]; other site 1173027010991 putative active site [active] 1173027010992 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1173027010993 putative catalytic site [active] 1173027010994 putative phosphate binding site [ion binding]; other site 1173027010995 active site 1173027010996 metal binding site A [ion binding]; metal-binding site 1173027010997 DNA binding site [nucleotide binding] 1173027010998 putative AP binding site [nucleotide binding]; other site 1173027010999 putative metal binding site B [ion binding]; other site 1173027011000 acetolactate synthase; Reviewed; Region: PRK08322 1173027011001 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173027011002 PYR/PP interface [polypeptide binding]; other site 1173027011003 dimer interface [polypeptide binding]; other site 1173027011004 TPP binding site [chemical binding]; other site 1173027011005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173027011006 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1173027011007 TPP-binding site [chemical binding]; other site 1173027011008 dimer interface [polypeptide binding]; other site 1173027011009 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1173027011010 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1173027011011 NAD(P) binding site [chemical binding]; other site 1173027011012 catalytic residues [active] 1173027011013 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011015 active site 1173027011016 phosphorylation site [posttranslational modification] 1173027011017 intermolecular recognition site; other site 1173027011018 dimerization interface [polypeptide binding]; other site 1173027011019 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173027011020 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011022 active site 1173027011023 phosphorylation site [posttranslational modification] 1173027011024 intermolecular recognition site; other site 1173027011025 dimerization interface [polypeptide binding]; other site 1173027011026 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173027011027 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1173027011028 putative NAD(P) binding site [chemical binding]; other site 1173027011029 catalytic Zn binding site [ion binding]; other site 1173027011030 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173027011031 Permease; Region: Permease; cl00510 1173027011032 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173027011033 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173027011034 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027011035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027011036 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173027011037 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1173027011038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173027011039 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027011040 cyclase homology domain; Region: CHD; cd07302 1173027011041 nucleotidyl binding site; other site 1173027011042 metal binding site [ion binding]; metal-binding site 1173027011043 dimer interface [polypeptide binding]; other site 1173027011044 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1173027011045 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1173027011046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027011047 ATP binding site [chemical binding]; other site 1173027011048 putative Mg++ binding site [ion binding]; other site 1173027011049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1173027011050 nucleotide binding region [chemical binding]; other site 1173027011051 ATP-binding site [chemical binding]; other site 1173027011052 hypothetical protein; Reviewed; Region: PRK00024 1173027011053 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1173027011054 MPN+ (JAMM) motif; other site 1173027011055 Zinc-binding site [ion binding]; other site 1173027011056 phosphoribulokinase; Provisional; Region: PRK07429 1173027011057 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173027011058 active site 1173027011059 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 1173027011060 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1173027011061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027011062 S-adenosylmethionine binding site [chemical binding]; other site 1173027011063 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 1173027011064 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173027011065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1173027011066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027011067 dimerization interface [polypeptide binding]; other site 1173027011068 putative DNA binding site [nucleotide binding]; other site 1173027011069 putative Zn2+ binding site [ion binding]; other site 1173027011070 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1173027011071 putative hydrophobic ligand binding site [chemical binding]; other site 1173027011072 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1173027011073 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027011074 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173027011075 C-terminal domain interface [polypeptide binding]; other site 1173027011076 GSH binding site (G-site) [chemical binding]; other site 1173027011077 dimer interface [polypeptide binding]; other site 1173027011078 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173027011079 N-terminal domain interface [polypeptide binding]; other site 1173027011080 dimer interface [polypeptide binding]; other site 1173027011081 substrate binding pocket (H-site) [chemical binding]; other site 1173027011082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027011083 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027011084 active site 1173027011085 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027011086 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027011087 CHAT domain; Region: CHAT; pfam12770 1173027011088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173027011089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173027011090 ABC transporter; Region: ABC_tran_2; pfam12848 1173027011091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173027011092 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1173027011093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027011094 active site 1173027011095 motif I; other site 1173027011096 motif II; other site 1173027011097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027011098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027011099 active site 1173027011100 catalytic tetrad [active] 1173027011101 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1173027011102 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1173027011103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027011104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011105 active site 1173027011106 phosphorylation site [posttranslational modification] 1173027011107 intermolecular recognition site; other site 1173027011108 dimerization interface [polypeptide binding]; other site 1173027011109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027011110 DNA binding site [nucleotide binding] 1173027011111 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173027011112 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173027011113 iron-sulfur cluster [ion binding]; other site 1173027011114 [2Fe-2S] cluster binding site [ion binding]; other site 1173027011115 Pheophorbide a oxygenase; Region: PaO; pfam08417 1173027011116 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1173027011117 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 1173027011118 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1173027011119 dimerization domain swap beta strand [polypeptide binding]; other site 1173027011120 regulatory protein interface [polypeptide binding]; other site 1173027011121 active site 1173027011122 regulatory phosphorylation site [posttranslational modification]; other site 1173027011123 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1173027011124 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1173027011125 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027011126 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173027011127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027011128 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173027011129 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027011130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027011131 active site 1173027011132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027011133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173027011134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027011135 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173027011136 NAD(P) binding site [chemical binding]; other site 1173027011137 active site 1173027011138 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1173027011139 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1173027011140 substrate binding site [chemical binding]; other site 1173027011141 active site 1173027011142 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1173027011143 dimer interface [polypeptide binding]; other site 1173027011144 catalytic triad [active] 1173027011145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027011146 binding surface 1173027011147 TPR motif; other site 1173027011148 TPR repeat; Region: TPR_11; pfam13414 1173027011149 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 1173027011150 Domain interface; other site 1173027011151 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173027011152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027011153 putative ADP-binding pocket [chemical binding]; other site 1173027011154 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173027011155 EamA-like transporter family; Region: EamA; pfam00892 1173027011156 EamA-like transporter family; Region: EamA; pfam00892 1173027011157 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173027011158 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1173027011159 tandem repeat interface [polypeptide binding]; other site 1173027011160 oligomer interface [polypeptide binding]; other site 1173027011161 active site residues [active] 1173027011162 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1173027011163 homotrimer interaction site [polypeptide binding]; other site 1173027011164 active site 1173027011165 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173027011166 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1173027011167 putative di-iron ligands [ion binding]; other site 1173027011168 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173027011169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027011170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027011171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173027011172 putative acyl-acceptor binding pocket; other site 1173027011173 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1173027011174 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1173027011175 active site 1173027011176 HIGH motif; other site 1173027011177 KMSKS motif; other site 1173027011178 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1173027011179 anticodon binding site; other site 1173027011180 tRNA binding surface [nucleotide binding]; other site 1173027011181 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173027011182 LabA_like proteins; Region: LabA; cd10911 1173027011183 putative metal binding site [ion binding]; other site 1173027011184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1173027011185 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173027011186 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173027011187 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173027011188 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1173027011189 putative phosphate acyltransferase; Provisional; Region: PRK05331 1173027011190 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1173027011191 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1173027011192 dimer interface [polypeptide binding]; other site 1173027011193 active site 1173027011194 CoA binding pocket [chemical binding]; other site 1173027011195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011196 active site 1173027011197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011198 phosphorylation site [posttranslational modification] 1173027011199 intermolecular recognition site; other site 1173027011200 dimerization interface [polypeptide binding]; other site 1173027011201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011202 dimer interface [polypeptide binding]; other site 1173027011203 phosphorylation site [posttranslational modification] 1173027011204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011205 ATP binding site [chemical binding]; other site 1173027011206 Mg2+ binding site [ion binding]; other site 1173027011207 G-X-G motif; other site 1173027011208 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027011209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027011210 binding surface 1173027011211 TPR motif; other site 1173027011212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027011213 16S rRNA methyltransferase B; Provisional; Region: PRK14901 1173027011214 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1173027011215 putative RNA binding site [nucleotide binding]; other site 1173027011216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027011217 S-adenosylmethionine binding site [chemical binding]; other site 1173027011218 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173027011219 metal binding site [ion binding]; metal-binding site 1173027011220 S-layer homology domain; Region: SLH; pfam00395 1173027011221 S-layer homology domain; Region: SLH; pfam00395 1173027011222 GAF domain; Region: GAF; pfam01590 1173027011223 GAF domain; Region: GAF_2; pfam13185 1173027011224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011226 dimer interface [polypeptide binding]; other site 1173027011227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011228 ATP binding site [chemical binding]; other site 1173027011229 Mg2+ binding site [ion binding]; other site 1173027011230 G-X-G motif; other site 1173027011231 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1173027011232 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 1173027011233 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173027011234 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173027011235 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173027011236 seryl-tRNA synthetase; Provisional; Region: PRK05431 1173027011237 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1173027011238 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1173027011239 dimer interface [polypeptide binding]; other site 1173027011240 active site 1173027011241 motif 1; other site 1173027011242 motif 2; other site 1173027011243 motif 3; other site 1173027011244 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1173027011245 active site 1173027011246 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173027011247 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1173027011248 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027011249 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1173027011250 putative NAD(P) binding site [chemical binding]; other site 1173027011251 active site 1173027011252 putative substrate binding site [chemical binding]; other site 1173027011253 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173027011254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011255 PAS domain; Region: PAS_9; pfam13426 1173027011256 putative active site [active] 1173027011257 heme pocket [chemical binding]; other site 1173027011258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011259 PAS domain; Region: PAS_9; pfam13426 1173027011260 putative active site [active] 1173027011261 heme pocket [chemical binding]; other site 1173027011262 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011263 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011265 dimer interface [polypeptide binding]; other site 1173027011266 phosphorylation site [posttranslational modification] 1173027011267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011268 ATP binding site [chemical binding]; other site 1173027011269 Mg2+ binding site [ion binding]; other site 1173027011270 G-X-G motif; other site 1173027011271 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027011272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011273 active site 1173027011274 phosphorylation site [posttranslational modification] 1173027011275 intermolecular recognition site; other site 1173027011276 PAS domain S-box; Region: sensory_box; TIGR00229 1173027011277 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027011278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011279 putative active site [active] 1173027011280 heme pocket [chemical binding]; other site 1173027011281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011282 dimer interface [polypeptide binding]; other site 1173027011283 phosphorylation site [posttranslational modification] 1173027011284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011285 ATP binding site [chemical binding]; other site 1173027011286 Mg2+ binding site [ion binding]; other site 1173027011287 G-X-G motif; other site 1173027011288 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1173027011289 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173027011290 minor groove reading motif; other site 1173027011291 helix-hairpin-helix signature motif; other site 1173027011292 substrate binding pocket [chemical binding]; other site 1173027011293 active site 1173027011294 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1173027011295 ribosomal protein S14; Region: rps14; CHL00074 1173027011296 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1173027011297 tartrate dehydrogenase; Region: TTC; TIGR02089 1173027011298 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1173027011299 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1173027011300 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1173027011301 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1173027011302 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1173027011303 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1173027011304 cytochrome c-550; Region: PS_II_C550; TIGR03045 1173027011305 cytochrome c-550; Provisional; Region: psbV; PRK13621 1173027011306 cytochrome c-550; Provisional; Region: psbV; cl17239 1173027011307 plastocyanin; Provisional; Region: PRK02710 1173027011308 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1173027011309 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173027011310 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173027011311 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1173027011312 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173027011313 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1173027011314 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1173027011315 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1173027011316 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173027011317 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173027011318 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173027011319 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1173027011320 D-pathway; other site 1173027011321 Putative ubiquinol binding site [chemical binding]; other site 1173027011322 Low-spin heme (heme b) binding site [chemical binding]; other site 1173027011323 Putative water exit pathway; other site 1173027011324 Binuclear center (heme o3/CuB) [ion binding]; other site 1173027011325 K-pathway; other site 1173027011326 Putative proton exit pathway; other site 1173027011327 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173027011328 Subunit I/III interface [polypeptide binding]; other site 1173027011329 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1173027011330 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1173027011331 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173027011332 active site 1173027011333 homodimer interface [polypeptide binding]; other site 1173027011334 catalytic site [active] 1173027011335 acceptor binding site [chemical binding]; other site 1173027011336 trehalose synthase; Region: treS_nterm; TIGR02456 1173027011337 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1173027011338 active site 1173027011339 catalytic site [active] 1173027011340 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1173027011341 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1173027011342 glycogen branching enzyme; Provisional; Region: PRK12313 1173027011343 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1173027011344 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1173027011345 active site 1173027011346 catalytic site [active] 1173027011347 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173027011348 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1173027011349 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1173027011350 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1173027011351 active site 1173027011352 catalytic site [active] 1173027011353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027011354 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027011355 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1173027011356 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1173027011357 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1173027011358 catalytic site [active] 1173027011359 active site 1173027011360 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173027011361 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1173027011362 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1173027011363 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1173027011364 catalytic site [active] 1173027011365 active site 1173027011366 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173027011367 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173027011368 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1173027011369 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1173027011370 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1173027011371 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173027011372 Amidase; Region: Amidase; pfam01425 1173027011373 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027011374 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173027011375 putative acyl-acceptor binding pocket; other site 1173027011376 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173027011377 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173027011378 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173027011379 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1173027011380 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173027011381 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1173027011382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027011383 sucrose synthase; Region: sucr_synth; TIGR02470 1173027011384 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027011385 putative ADP-binding pocket [chemical binding]; other site 1173027011386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173027011387 active site 1173027011388 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1173027011389 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027011390 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027011391 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027011392 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027011393 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027011394 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027011395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027011396 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173027011397 active site 1173027011398 metal binding site [ion binding]; metal-binding site 1173027011399 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 1173027011400 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173027011401 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1173027011402 trimer interface [polypeptide binding]; other site 1173027011403 putative metal binding site [ion binding]; other site 1173027011404 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 1173027011405 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027011406 Walker A motif; other site 1173027011407 ATP binding site [chemical binding]; other site 1173027011408 GAF domain; Region: GAF; cl17456 1173027011409 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011410 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011411 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011412 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011413 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011414 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027011415 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027011416 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1173027011417 ScpA/B protein; Region: ScpA_ScpB; cl00598 1173027011418 ScpA/B protein; Region: ScpA_ScpB; cl00598 1173027011419 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173027011420 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173027011421 active site 1173027011422 Substrate binding site; other site 1173027011423 Mg++ binding site; other site 1173027011424 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173027011425 putative trimer interface [polypeptide binding]; other site 1173027011426 putative CoA binding site [chemical binding]; other site 1173027011427 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173027011428 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027011429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027011430 S-adenosylmethionine binding site [chemical binding]; other site 1173027011431 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 1173027011432 NADH dehydrogenase; Region: NADHdh; cl00469 1173027011433 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1173027011434 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027011435 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 1173027011436 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1173027011437 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1173027011438 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 1173027011439 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1173027011440 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1173027011441 substrate binding site [chemical binding]; other site 1173027011442 ligand binding site [chemical binding]; other site 1173027011443 adenylate kinase; Provisional; Region: PRK13808 1173027011444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027011445 S-adenosylmethionine binding site [chemical binding]; other site 1173027011446 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1173027011447 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1173027011448 substrate binding site [chemical binding]; other site 1173027011449 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1173027011450 amphipathic channel; other site 1173027011451 Asn-Pro-Ala signature motifs; other site 1173027011452 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1173027011453 putative active site [active] 1173027011454 putative metal binding residues [ion binding]; other site 1173027011455 signature motif; other site 1173027011456 putative dimer interface [polypeptide binding]; other site 1173027011457 putative phosphate binding site [ion binding]; other site 1173027011458 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173027011459 recombination protein F; Reviewed; Region: recF; PRK00064 1173027011460 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1173027011461 Walker A/P-loop; other site 1173027011462 ATP binding site [chemical binding]; other site 1173027011463 Q-loop/lid; other site 1173027011464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027011465 ABC transporter signature motif; other site 1173027011466 Walker B; other site 1173027011467 D-loop; other site 1173027011468 H-loop/switch region; other site 1173027011469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173027011470 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173027011471 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027011472 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173027011473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027011474 motif II; other site 1173027011475 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173027011476 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173027011477 putative lipid kinase; Reviewed; Region: PRK13057 1173027011478 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173027011479 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027011480 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027011481 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173027011482 RNA binding site [nucleotide binding]; other site 1173027011483 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1173027011484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1173027011485 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173027011486 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173027011487 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173027011488 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173027011489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027011490 active site 1173027011491 motif I; other site 1173027011492 motif II; other site 1173027011493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011494 putative active site [active] 1173027011495 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027011496 heme pocket [chemical binding]; other site 1173027011497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011498 dimer interface [polypeptide binding]; other site 1173027011499 phosphorylation site [posttranslational modification] 1173027011500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011501 ATP binding site [chemical binding]; other site 1173027011502 Mg2+ binding site [ion binding]; other site 1173027011503 G-X-G motif; other site 1173027011504 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027011505 putative active site [active] 1173027011506 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1173027011507 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173027011508 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027011509 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173027011510 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173027011511 catalytic residues [active] 1173027011512 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1173027011513 feedback inhibition sensing region; other site 1173027011514 homohexameric interface [polypeptide binding]; other site 1173027011515 nucleotide binding site [chemical binding]; other site 1173027011516 N-acetyl-L-glutamate binding site [chemical binding]; other site 1173027011517 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173027011518 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173027011519 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173027011520 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173027011521 shikimate kinase; Reviewed; Region: aroK; PRK00131 1173027011522 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1173027011523 ADP binding site [chemical binding]; other site 1173027011524 magnesium binding site [ion binding]; other site 1173027011525 putative shikimate binding site; other site 1173027011526 aromatic acid decarboxylase; Validated; Region: PRK05920 1173027011527 Flavoprotein; Region: Flavoprotein; pfam02441 1173027011528 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173027011529 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1173027011530 RNB domain; Region: RNB; pfam00773 1173027011531 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1173027011532 RNA binding site [nucleotide binding]; other site 1173027011533 Clp protease; Region: CLP_protease; pfam00574 1173027011534 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173027011535 oligomer interface [polypeptide binding]; other site 1173027011536 active site residues [active] 1173027011537 TPR repeat; Region: TPR_11; pfam13414 1173027011538 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173027011539 TPR repeat; Region: TPR_11; pfam13414 1173027011540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027011541 binding surface 1173027011542 TPR motif; other site 1173027011543 TPR repeat; Region: TPR_11; pfam13414 1173027011544 TPR repeat; Region: TPR_11; pfam13414 1173027011545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027011546 binding surface 1173027011547 TPR motif; other site 1173027011548 TPR repeat; Region: TPR_11; pfam13414 1173027011549 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1173027011550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173027011551 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173027011552 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1173027011553 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173027011554 Fasciclin domain; Region: Fasciclin; pfam02469 1173027011555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027011556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027011557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027011558 Walker A/P-loop; other site 1173027011559 ATP binding site [chemical binding]; other site 1173027011560 Q-loop/lid; other site 1173027011561 ABC transporter signature motif; other site 1173027011562 Walker B; other site 1173027011563 D-loop; other site 1173027011564 H-loop/switch region; other site 1173027011565 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027011566 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027011567 putative active site [active] 1173027011568 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173027011569 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173027011570 NAD binding site [chemical binding]; other site 1173027011571 homodimer interface [polypeptide binding]; other site 1173027011572 active site 1173027011573 substrate binding site [chemical binding]; other site 1173027011574 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1173027011575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027011576 putative ADP-binding pocket [chemical binding]; other site 1173027011577 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173027011578 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173027011579 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173027011580 NADP-binding site; other site 1173027011581 homotetramer interface [polypeptide binding]; other site 1173027011582 substrate binding site [chemical binding]; other site 1173027011583 homodimer interface [polypeptide binding]; other site 1173027011584 active site 1173027011585 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1173027011586 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1173027011587 NADP binding site [chemical binding]; other site 1173027011588 active site 1173027011589 putative substrate binding site [chemical binding]; other site 1173027011590 TniQ; Region: TniQ; pfam06527 1173027011591 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1173027011592 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1173027011593 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027011594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027011595 dimer interface [polypeptide binding]; other site 1173027011596 conserved gate region; other site 1173027011597 putative PBP binding loops; other site 1173027011598 ABC-ATPase subunit interface; other site 1173027011599 cyanate hydratase; Validated; Region: PRK02866 1173027011600 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1173027011601 oligomer interface [polypeptide binding]; other site 1173027011602 active site 1173027011603 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173027011604 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173027011605 MraW methylase family; Region: Methyltransf_5; cl17771 1173027011606 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1173027011607 rod shape-determining protein MreC; Provisional; Region: PRK13922 1173027011608 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1173027011609 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1173027011610 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1173027011611 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173027011612 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027011613 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173027011614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027011615 ATP binding site [chemical binding]; other site 1173027011616 putative Mg++ binding site [ion binding]; other site 1173027011617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027011618 nucleotide binding region [chemical binding]; other site 1173027011619 ATP-binding site [chemical binding]; other site 1173027011620 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1173027011621 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027011622 Cytochrome P450; Region: p450; cl12078 1173027011623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027011624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027011625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027011626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027011627 binding surface 1173027011628 TPR motif; other site 1173027011629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027011630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027011631 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1173027011632 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1173027011633 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1173027011634 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1173027011635 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1173027011636 dimer interface [polypeptide binding]; other site 1173027011637 active site 1173027011638 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1173027011639 folate binding site [chemical binding]; other site 1173027011640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027011641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027011642 Coenzyme A binding pocket [chemical binding]; other site 1173027011643 competence damage-inducible protein A; Provisional; Region: PRK00549 1173027011644 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1173027011645 putative MPT binding site; other site 1173027011646 Competence-damaged protein; Region: CinA; pfam02464 1173027011647 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1173027011648 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1173027011649 trimer interface [polypeptide binding]; other site 1173027011650 active site 1173027011651 dimer interface [polypeptide binding]; other site 1173027011652 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1173027011653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011655 dimer interface [polypeptide binding]; other site 1173027011656 phosphorylation site [posttranslational modification] 1173027011657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011658 ATP binding site [chemical binding]; other site 1173027011659 Mg2+ binding site [ion binding]; other site 1173027011660 G-X-G motif; other site 1173027011661 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1173027011662 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1173027011663 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1173027011664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027011665 Zn2+ binding site [ion binding]; other site 1173027011666 Mg2+ binding site [ion binding]; other site 1173027011667 malate dehydrogenase; Reviewed; Region: PRK06223 1173027011668 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1173027011669 NAD(P) binding site [chemical binding]; other site 1173027011670 dimer interface [polypeptide binding]; other site 1173027011671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027011672 substrate binding site [chemical binding]; other site 1173027011673 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 1173027011674 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1173027011675 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1173027011676 DNA binding site [nucleotide binding] 1173027011677 catalytic residue [active] 1173027011678 H2TH interface [polypeptide binding]; other site 1173027011679 putative catalytic residues [active] 1173027011680 turnover-facilitating residue; other site 1173027011681 intercalation triad [nucleotide binding]; other site 1173027011682 8OG recognition residue [nucleotide binding]; other site 1173027011683 putative reading head residues; other site 1173027011684 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173027011685 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173027011686 photosystem I subunit IV; Reviewed; Region: psaE; CHL00125 1173027011687 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 1173027011688 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1173027011689 YcaO-like family; Region: YcaO; pfam02624 1173027011690 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1173027011691 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1173027011692 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1173027011693 putative metal binding site [ion binding]; other site 1173027011694 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 1173027011695 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1173027011696 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1173027011697 putative metal binding site [ion binding]; other site 1173027011698 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1173027011699 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1173027011700 putative metal binding site [ion binding]; other site 1173027011701 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1173027011702 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173027011703 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1173027011704 active site 1173027011705 Fe-S cluster binding site [ion binding]; other site 1173027011706 citrate synthase; Provisional; Region: PRK14036 1173027011707 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 1173027011708 dimer interface [polypeptide binding]; other site 1173027011709 active site 1173027011710 citrylCoA binding site [chemical binding]; other site 1173027011711 oxalacetate/citrate binding site [chemical binding]; other site 1173027011712 coenzyme A binding site [chemical binding]; other site 1173027011713 catalytic triad [active] 1173027011714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173027011715 catalytic core [active] 1173027011716 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173027011717 DHH family; Region: DHH; pfam01368 1173027011718 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027011719 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027011720 active site 1173027011721 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027011722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011723 active site 1173027011724 phosphorylation site [posttranslational modification] 1173027011725 intermolecular recognition site; other site 1173027011726 dimerization interface [polypeptide binding]; other site 1173027011727 PAS domain S-box; Region: sensory_box; TIGR00229 1173027011728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011729 putative active site [active] 1173027011730 heme pocket [chemical binding]; other site 1173027011731 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027011732 cyclase homology domain; Region: CHD; cd07302 1173027011733 nucleotidyl binding site; other site 1173027011734 metal binding site [ion binding]; metal-binding site 1173027011735 dimer interface [polypeptide binding]; other site 1173027011736 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027011737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011738 active site 1173027011739 phosphorylation site [posttranslational modification] 1173027011740 intermolecular recognition site; other site 1173027011741 dimerization interface [polypeptide binding]; other site 1173027011742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027011743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027011744 metal binding site [ion binding]; metal-binding site 1173027011745 active site 1173027011746 I-site; other site 1173027011747 PAS domain S-box; Region: sensory_box; TIGR00229 1173027011748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011749 putative active site [active] 1173027011750 heme pocket [chemical binding]; other site 1173027011751 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011752 GAF domain; Region: GAF; pfam01590 1173027011753 PAS fold; Region: PAS_7; pfam12860 1173027011754 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027011755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011756 putative active site [active] 1173027011757 heme pocket [chemical binding]; other site 1173027011758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011759 dimer interface [polypeptide binding]; other site 1173027011760 phosphorylation site [posttranslational modification] 1173027011761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011762 ATP binding site [chemical binding]; other site 1173027011763 Mg2+ binding site [ion binding]; other site 1173027011764 G-X-G motif; other site 1173027011765 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011767 active site 1173027011768 phosphorylation site [posttranslational modification] 1173027011769 intermolecular recognition site; other site 1173027011770 dimerization interface [polypeptide binding]; other site 1173027011771 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027011772 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173027011773 AAA ATPase domain; Region: AAA_16; pfam13191 1173027011774 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1173027011775 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173027011776 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173027011777 DNA methylase; Region: N6_N4_Mtase; cl17433 1173027011778 DNA methylase; Region: N6_N4_Mtase; pfam01555 1173027011779 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1173027011780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027011781 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173027011782 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173027011783 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173027011784 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1173027011785 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027011786 putative active site [active] 1173027011787 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1173027011788 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173027011789 putative catalytic site [active] 1173027011790 putative metal binding site [ion binding]; other site 1173027011791 putative phosphate binding site [ion binding]; other site 1173027011792 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1173027011793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173027011794 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1173027011795 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1173027011796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1173027011797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027011798 Cytochrome P450; Region: p450; cl12078 1173027011799 Leucine rich repeat; Region: LRR_8; pfam13855 1173027011800 Leucine rich repeat; Region: LRR_8; pfam13855 1173027011801 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027011802 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027011803 active site 1173027011804 ATP binding site [chemical binding]; other site 1173027011805 substrate binding site [chemical binding]; other site 1173027011806 activation loop (A-loop); other site 1173027011807 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027011808 structural tetrad; other site 1173027011809 PQQ-like domain; Region: PQQ_2; pfam13360 1173027011810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027011811 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027011812 active site 1173027011813 ATP binding site [chemical binding]; other site 1173027011814 substrate binding site [chemical binding]; other site 1173027011815 activation loop (A-loop); other site 1173027011816 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027011817 AAA ATPase domain; Region: AAA_16; pfam13191 1173027011818 Predicted ATPase [General function prediction only]; Region: COG3899 1173027011819 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011820 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011823 dimer interface [polypeptide binding]; other site 1173027011824 phosphorylation site [posttranslational modification] 1173027011825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011826 ATP binding site [chemical binding]; other site 1173027011827 Mg2+ binding site [ion binding]; other site 1173027011828 G-X-G motif; other site 1173027011829 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027011830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011831 active site 1173027011832 phosphorylation site [posttranslational modification] 1173027011833 intermolecular recognition site; other site 1173027011834 dimerization interface [polypeptide binding]; other site 1173027011835 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011837 active site 1173027011838 phosphorylation site [posttranslational modification] 1173027011839 intermolecular recognition site; other site 1173027011840 dimerization interface [polypeptide binding]; other site 1173027011841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011842 dimer interface [polypeptide binding]; other site 1173027011843 phosphorylation site [posttranslational modification] 1173027011844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011846 ATP binding site [chemical binding]; other site 1173027011847 Mg2+ binding site [ion binding]; other site 1173027011848 G-X-G motif; other site 1173027011849 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011851 active site 1173027011852 phosphorylation site [posttranslational modification] 1173027011853 intermolecular recognition site; other site 1173027011854 dimerization interface [polypeptide binding]; other site 1173027011855 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011857 active site 1173027011858 phosphorylation site [posttranslational modification] 1173027011859 intermolecular recognition site; other site 1173027011860 dimerization interface [polypeptide binding]; other site 1173027011861 PAS domain; Region: PAS_9; pfam13426 1173027011862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011863 putative active site [active] 1173027011864 heme pocket [chemical binding]; other site 1173027011865 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027011866 cyclase homology domain; Region: CHD; cd07302 1173027011867 nucleotidyl binding site; other site 1173027011868 metal binding site [ion binding]; metal-binding site 1173027011869 dimer interface [polypeptide binding]; other site 1173027011870 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173027011871 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173027011872 iron-sulfur cluster [ion binding]; other site 1173027011873 [2Fe-2S] cluster binding site [ion binding]; other site 1173027011874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027011875 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173027011876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173027011877 iron-sulfur cluster [ion binding]; other site 1173027011878 [2Fe-2S] cluster binding site [ion binding]; other site 1173027011879 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1173027011880 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173027011881 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173027011882 PAS fold; Region: PAS; pfam00989 1173027011883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011884 putative active site [active] 1173027011885 heme pocket [chemical binding]; other site 1173027011886 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027011889 dimer interface [polypeptide binding]; other site 1173027011890 phosphorylation site [posttranslational modification] 1173027011891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011892 ATP binding site [chemical binding]; other site 1173027011893 Mg2+ binding site [ion binding]; other site 1173027011894 G-X-G motif; other site 1173027011895 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027011896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027011897 active site 1173027011898 phosphorylation site [posttranslational modification] 1173027011899 intermolecular recognition site; other site 1173027011900 dimerization interface [polypeptide binding]; other site 1173027011901 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027011902 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1173027011903 Walker A/P-loop; other site 1173027011904 ATP binding site [chemical binding]; other site 1173027011905 Q-loop/lid; other site 1173027011906 ABC transporter signature motif; other site 1173027011907 Walker B; other site 1173027011908 D-loop; other site 1173027011909 H-loop/switch region; other site 1173027011910 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027011911 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1173027011912 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 1173027011913 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027011914 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173027011915 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027011916 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027011917 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173027011918 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173027011919 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027011920 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027011921 ligand binding site [chemical binding]; other site 1173027011922 flexible hinge region; other site 1173027011923 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011924 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011925 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027011926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011927 putative active site [active] 1173027011928 heme pocket [chemical binding]; other site 1173027011929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011930 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027011931 putative active site [active] 1173027011932 heme pocket [chemical binding]; other site 1173027011933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027011934 putative active site [active] 1173027011935 heme pocket [chemical binding]; other site 1173027011936 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027011937 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027011938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027011939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027011940 ATP binding site [chemical binding]; other site 1173027011941 Mg2+ binding site [ion binding]; other site 1173027011942 G-X-G motif; other site 1173027011943 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027011944 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027011945 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027011946 putative active site [active] 1173027011947 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1173027011948 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027011949 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027011950 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027011951 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027011952 GUN4-like; Region: GUN4; pfam05419 1173027011953 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1173027011954 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1173027011955 phosphatidate cytidylyltransferase; Region: PLN02953 1173027011956 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173027011957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027011958 S-adenosylmethionine binding site [chemical binding]; other site 1173027011959 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1173027011960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027011961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027011962 catalytic residue [active] 1173027011963 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1173027011964 GTP-binding protein YchF; Reviewed; Region: PRK09601 1173027011965 YchF GTPase; Region: YchF; cd01900 1173027011966 G1 box; other site 1173027011967 GTP/Mg2+ binding site [chemical binding]; other site 1173027011968 Switch I region; other site 1173027011969 G2 box; other site 1173027011970 Switch II region; other site 1173027011971 G3 box; other site 1173027011972 G4 box; other site 1173027011973 G5 box; other site 1173027011974 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1173027011975 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 1173027011976 Transglycosylase; Region: Transgly; pfam00912 1173027011977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173027011978 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1173027011979 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027011980 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027011981 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173027011982 CHAT domain; Region: CHAT; cl17868 1173027011983 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027011984 CHASE2 domain; Region: CHASE2; pfam05226 1173027011985 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027011986 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027011987 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1173027011988 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1173027011989 CoA binding domain; Region: CoA_binding; smart00881 1173027011990 CoA-ligase; Region: Ligase_CoA; pfam00549 1173027011991 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1173027011992 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1173027011993 short chain dehydrogenase; Validated; Region: PRK06182 1173027011994 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1173027011995 NADP binding site [chemical binding]; other site 1173027011996 active site 1173027011997 steroid binding site; other site 1173027011998 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1173027011999 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1173027012000 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 1173027012001 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1173027012002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027012003 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1173027012004 glutaminase A; Region: Gln_ase; TIGR03814 1173027012005 Cache domain; Region: Cache_1; pfam02743 1173027012006 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027012007 dimerization interface [polypeptide binding]; other site 1173027012008 PAS domain S-box; Region: sensory_box; TIGR00229 1173027012009 PAS domain S-box; Region: sensory_box; TIGR00229 1173027012010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012011 putative active site [active] 1173027012012 heme pocket [chemical binding]; other site 1173027012013 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027012014 cyclase homology domain; Region: CHD; cd07302 1173027012015 nucleotidyl binding site; other site 1173027012016 metal binding site [ion binding]; metal-binding site 1173027012017 dimer interface [polypeptide binding]; other site 1173027012018 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1173027012019 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173027012020 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173027012021 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1173027012022 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173027012023 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027012024 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1173027012025 IMP binding site; other site 1173027012026 dimer interface [polypeptide binding]; other site 1173027012027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027012028 non-specific DNA binding site [nucleotide binding]; other site 1173027012029 salt bridge; other site 1173027012030 sequence-specific DNA binding site [nucleotide binding]; other site 1173027012031 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027012032 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1173027012033 cofactor binding site; other site 1173027012034 DNA binding site [nucleotide binding] 1173027012035 substrate interaction site [chemical binding]; other site 1173027012036 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027012037 ribonuclease III; Reviewed; Region: rnc; PRK00102 1173027012038 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173027012039 dimerization interface [polypeptide binding]; other site 1173027012040 active site 1173027012041 metal binding site [ion binding]; metal-binding site 1173027012042 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173027012043 dsRNA binding site [nucleotide binding]; other site 1173027012044 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012045 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027012046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012048 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027012049 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012050 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027012051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012052 binding surface 1173027012053 TPR motif; other site 1173027012054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012055 binding surface 1173027012056 TPR motif; other site 1173027012057 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027012058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027012059 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1173027012060 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1173027012061 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012063 active site 1173027012064 phosphorylation site [posttranslational modification] 1173027012065 intermolecular recognition site; other site 1173027012066 dimerization interface [polypeptide binding]; other site 1173027012067 PAS fold; Region: PAS_4; pfam08448 1173027012068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012069 putative active site [active] 1173027012070 heme pocket [chemical binding]; other site 1173027012071 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027012072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012073 putative active site [active] 1173027012074 heme pocket [chemical binding]; other site 1173027012075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012076 dimer interface [polypeptide binding]; other site 1173027012077 phosphorylation site [posttranslational modification] 1173027012078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012079 ATP binding site [chemical binding]; other site 1173027012080 Mg2+ binding site [ion binding]; other site 1173027012081 G-X-G motif; other site 1173027012082 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012084 active site 1173027012085 phosphorylation site [posttranslational modification] 1173027012086 intermolecular recognition site; other site 1173027012087 dimerization interface [polypeptide binding]; other site 1173027012088 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173027012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012090 ATP binding site [chemical binding]; other site 1173027012091 Mg2+ binding site [ion binding]; other site 1173027012092 G-X-G motif; other site 1173027012093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027012094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012095 dimer interface [polypeptide binding]; other site 1173027012096 phosphorylation site [posttranslational modification] 1173027012097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012098 ATP binding site [chemical binding]; other site 1173027012099 Mg2+ binding site [ion binding]; other site 1173027012100 G-X-G motif; other site 1173027012101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012103 active site 1173027012104 phosphorylation site [posttranslational modification] 1173027012105 intermolecular recognition site; other site 1173027012106 dimerization interface [polypeptide binding]; other site 1173027012107 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012109 active site 1173027012110 phosphorylation site [posttranslational modification] 1173027012111 intermolecular recognition site; other site 1173027012112 dimerization interface [polypeptide binding]; other site 1173027012113 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027012114 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173027012115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012116 ATP binding site [chemical binding]; other site 1173027012117 Mg2+ binding site [ion binding]; other site 1173027012118 G-X-G motif; other site 1173027012119 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1173027012120 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1173027012121 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1173027012122 Penicillin amidase; Region: Penicil_amidase; pfam01804 1173027012123 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1173027012124 active site 1173027012125 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1173027012126 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027012127 putative active site [active] 1173027012128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012129 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012130 active site 1173027012131 phosphorylation site [posttranslational modification] 1173027012132 intermolecular recognition site; other site 1173027012133 dimerization interface [polypeptide binding]; other site 1173027012134 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027012135 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1173027012136 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027012137 nudix motif; other site 1173027012138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027012139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027012140 active site 1173027012141 catalytic tetrad [active] 1173027012142 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027012143 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027012144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027012145 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027012146 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027012147 putative binding surface; other site 1173027012148 active site 1173027012149 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027012150 Special lobe-specific silk protein SSP160; Region: SSP160; pfam06933 1173027012151 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027012152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012153 ATP binding site [chemical binding]; other site 1173027012154 Mg2+ binding site [ion binding]; other site 1173027012155 G-X-G motif; other site 1173027012156 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027012157 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012159 active site 1173027012160 phosphorylation site [posttranslational modification] 1173027012161 intermolecular recognition site; other site 1173027012162 dimerization interface [polypeptide binding]; other site 1173027012163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027012164 dimerization interface [polypeptide binding]; other site 1173027012165 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012166 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012167 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173027012168 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027012169 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027012170 dimer interface [polypeptide binding]; other site 1173027012171 putative CheW interface [polypeptide binding]; other site 1173027012172 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027012173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012174 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012175 active site 1173027012176 phosphorylation site [posttranslational modification] 1173027012177 intermolecular recognition site; other site 1173027012178 dimerization interface [polypeptide binding]; other site 1173027012179 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012181 active site 1173027012182 phosphorylation site [posttranslational modification] 1173027012183 intermolecular recognition site; other site 1173027012184 dimerization interface [polypeptide binding]; other site 1173027012185 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173027012186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027012187 ATP binding site [chemical binding]; other site 1173027012188 putative Mg++ binding site [ion binding]; other site 1173027012189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027012190 nucleotide binding region [chemical binding]; other site 1173027012191 ATP-binding site [chemical binding]; other site 1173027012192 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1173027012193 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173027012194 acyl-activating enzyme (AAE) consensus motif; other site 1173027012195 AMP binding site [chemical binding]; other site 1173027012196 PilZ domain; Region: PilZ; pfam07238 1173027012197 PilZ domain; Region: PilZ; pfam07238 1173027012198 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173027012199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173027012200 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1173027012201 thioester reductase domain; Region: Thioester-redct; TIGR01746 1173027012202 putative NAD(P) binding site [chemical binding]; other site 1173027012203 active site 1173027012204 putative substrate binding site [chemical binding]; other site 1173027012205 ethanolamine permease; Region: 2A0305; TIGR00908 1173027012206 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027012207 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027012208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027012209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012211 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027012212 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012213 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027012214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027012215 dimer interface [polypeptide binding]; other site 1173027012216 conserved gate region; other site 1173027012217 putative PBP binding loops; other site 1173027012218 ABC-ATPase subunit interface; other site 1173027012219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027012220 Coenzyme A binding pocket [chemical binding]; other site 1173027012221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027012222 non-specific DNA binding site [nucleotide binding]; other site 1173027012223 salt bridge; other site 1173027012224 sequence-specific DNA binding site [nucleotide binding]; other site 1173027012225 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027012226 putative active site [active] 1173027012227 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1173027012228 active site 1173027012229 dinuclear metal binding site [ion binding]; other site 1173027012230 dimerization interface [polypeptide binding]; other site 1173027012231 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1173027012232 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027012233 active site 1173027012234 metal binding site [ion binding]; metal-binding site 1173027012235 Peptidase family M48; Region: Peptidase_M48; pfam01435 1173027012236 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1173027012237 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027012238 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027012239 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 1173027012240 putative active site [active] 1173027012241 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1173027012242 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173027012243 NodB motif; other site 1173027012244 active site 1173027012245 catalytic site [active] 1173027012246 metal binding site [ion binding]; metal-binding site 1173027012247 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 1173027012248 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173027012249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027012250 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027012251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027012252 DNA binding residues [nucleotide binding] 1173027012253 putative high light inducible protein; Region: PHA02337 1173027012254 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173027012255 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1173027012256 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173027012257 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173027012258 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1173027012259 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027012260 DXD motif; other site 1173027012261 PilZ domain; Region: PilZ; pfam07238 1173027012262 PAS domain S-box; Region: sensory_box; TIGR00229 1173027012263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012264 putative active site [active] 1173027012265 heme pocket [chemical binding]; other site 1173027012266 GAF domain; Region: GAF_3; pfam13492 1173027012267 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027012269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027012270 metal binding site [ion binding]; metal-binding site 1173027012271 active site 1173027012272 I-site; other site 1173027012273 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1173027012274 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1173027012275 Catalytic site; other site 1173027012276 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012277 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1173027012278 active site 1173027012279 ATP binding site [chemical binding]; other site 1173027012280 substrate binding site [chemical binding]; other site 1173027012281 activation loop (A-loop); other site 1173027012282 AAA ATPase domain; Region: AAA_16; pfam13191 1173027012283 Predicted ATPase [General function prediction only]; Region: COG3899 1173027012284 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012285 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012286 PAS fold; Region: PAS_4; pfam08448 1173027012287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027012288 cyclase homology domain; Region: CHD; cd07302 1173027012289 nucleotidyl binding site; other site 1173027012290 metal binding site [ion binding]; metal-binding site 1173027012291 dimer interface [polypeptide binding]; other site 1173027012292 Protein kinase domain; Region: Pkinase; pfam00069 1173027012293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012294 active site 1173027012295 ATP binding site [chemical binding]; other site 1173027012296 substrate binding site [chemical binding]; other site 1173027012297 activation loop (A-loop); other site 1173027012298 AAA ATPase domain; Region: AAA_16; pfam13191 1173027012299 Predicted ATPase [General function prediction only]; Region: COG3899 1173027012300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012301 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012302 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027012303 cyclase homology domain; Region: CHD; cd07302 1173027012304 nucleotidyl binding site; other site 1173027012305 metal binding site [ion binding]; metal-binding site 1173027012306 dimer interface [polypeptide binding]; other site 1173027012307 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173027012308 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173027012309 active site 1173027012310 substrate binding site [chemical binding]; other site 1173027012311 metal binding site [ion binding]; metal-binding site 1173027012312 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173027012313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012314 binding surface 1173027012315 TPR repeat; Region: TPR_11; pfam13414 1173027012316 TPR motif; other site 1173027012317 TPR repeat; Region: TPR_11; pfam13414 1173027012318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012319 binding surface 1173027012320 TPR motif; other site 1173027012321 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027012322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012323 binding surface 1173027012324 TPR motif; other site 1173027012325 TPR repeat; Region: TPR_11; pfam13414 1173027012326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012327 binding surface 1173027012328 TPR motif; other site 1173027012329 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173027012330 Double zinc ribbon; Region: DZR; pfam12773 1173027012331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027012332 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012333 active site 1173027012334 ATP binding site [chemical binding]; other site 1173027012335 substrate binding site [chemical binding]; other site 1173027012336 activation loop (A-loop); other site 1173027012337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027012338 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027012339 structural tetrad; other site 1173027012340 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173027012341 Double zinc ribbon; Region: DZR; pfam12773 1173027012342 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027012343 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012344 active site 1173027012345 ATP binding site [chemical binding]; other site 1173027012346 substrate binding site [chemical binding]; other site 1173027012347 activation loop (A-loop); other site 1173027012348 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027012349 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027012350 structural tetrad; other site 1173027012351 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1173027012352 Glycoprotease family; Region: Peptidase_M22; pfam00814 1173027012353 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173027012354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173027012355 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027012356 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1173027012357 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027012358 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027012359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027012360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027012361 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173027012362 Probable transposase; Region: OrfB_IS605; pfam01385 1173027012363 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1173027012364 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1173027012365 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1173027012366 trimer interface [polypeptide binding]; other site 1173027012367 active site 1173027012368 UDP-GlcNAc binding site [chemical binding]; other site 1173027012369 lipid binding site [chemical binding]; lipid-binding site 1173027012370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012372 binding surface 1173027012373 TPR motif; other site 1173027012374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012376 binding surface 1173027012377 TPR motif; other site 1173027012378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012381 binding surface 1173027012382 TPR motif; other site 1173027012383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027012385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027012386 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173027012387 putative active site [active] 1173027012388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027012389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173027012390 non-specific DNA binding site [nucleotide binding]; other site 1173027012391 salt bridge; other site 1173027012392 sequence-specific DNA binding site [nucleotide binding]; other site 1173027012393 flavoprotein, HI0933 family; Region: TIGR00275 1173027012394 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173027012395 Rubredoxin; Region: Rubredoxin; pfam00301 1173027012396 iron binding site [ion binding]; other site 1173027012397 ChaB; Region: ChaB; pfam06150 1173027012398 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1173027012399 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027012400 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027012401 putative active site [active] 1173027012402 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027012403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027012404 S-adenosylmethionine binding site [chemical binding]; other site 1173027012405 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1173027012406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027012407 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1173027012408 dimerization interface [polypeptide binding]; other site 1173027012409 substrate binding pocket [chemical binding]; other site 1173027012410 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173027012411 PAS domain; Region: PAS; smart00091 1173027012412 PAS fold; Region: PAS_4; pfam08448 1173027012413 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027012414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012415 dimer interface [polypeptide binding]; other site 1173027012416 phosphorylation site [posttranslational modification] 1173027012417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012418 ATP binding site [chemical binding]; other site 1173027012419 Mg2+ binding site [ion binding]; other site 1173027012420 G-X-G motif; other site 1173027012421 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012423 active site 1173027012424 phosphorylation site [posttranslational modification] 1173027012425 intermolecular recognition site; other site 1173027012426 dimerization interface [polypeptide binding]; other site 1173027012427 Predicted membrane protein [Function unknown]; Region: COG3463 1173027012428 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1173027012429 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1173027012430 adhesin; Provisional; Region: PRK09752 1173027012431 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173027012432 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027012433 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173027012434 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027012435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012436 binding surface 1173027012437 TPR motif; other site 1173027012438 TPR repeat; Region: TPR_11; pfam13414 1173027012439 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1173027012440 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173027012441 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173027012442 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027012443 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027012444 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027012445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1173027012446 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173027012447 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027012448 active site 1173027012449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027012450 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1173027012451 Fe-S cluster binding site [ion binding]; other site 1173027012452 active site 1173027012453 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1173027012454 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1173027012455 5S rRNA interface [nucleotide binding]; other site 1173027012456 CTC domain interface [polypeptide binding]; other site 1173027012457 L16 interface [polypeptide binding]; other site 1173027012458 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1173027012459 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1173027012460 GDP-binding site [chemical binding]; other site 1173027012461 ACT binding site; other site 1173027012462 IMP binding site; other site 1173027012463 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1173027012464 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 1173027012465 active site 1173027012466 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012467 PAS domain; Region: PAS_9; pfam13426 1173027012468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012469 putative active site [active] 1173027012470 heme pocket [chemical binding]; other site 1173027012471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012472 PAS fold; Region: PAS_3; pfam08447 1173027012473 putative active site [active] 1173027012474 heme pocket [chemical binding]; other site 1173027012475 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012476 GAF domain; Region: GAF_3; pfam13492 1173027012477 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012478 GAF domain; Region: GAF; pfam01590 1173027012479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027012480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012481 dimer interface [polypeptide binding]; other site 1173027012482 phosphorylation site [posttranslational modification] 1173027012483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012484 ATP binding site [chemical binding]; other site 1173027012485 Mg2+ binding site [ion binding]; other site 1173027012486 G-X-G motif; other site 1173027012487 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027012488 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012489 active site 1173027012490 ATP binding site [chemical binding]; other site 1173027012491 substrate binding site [chemical binding]; other site 1173027012492 activation loop (A-loop); other site 1173027012493 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1173027012494 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027012495 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027012496 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012497 active site 1173027012498 ATP binding site [chemical binding]; other site 1173027012499 substrate binding site [chemical binding]; other site 1173027012500 activation loop (A-loop); other site 1173027012501 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1173027012502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173027012503 acyl-activating enzyme (AAE) consensus motif; other site 1173027012504 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173027012505 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1173027012506 active site 1173027012507 substrate binding site [chemical binding]; other site 1173027012508 metal binding site [ion binding]; metal-binding site 1173027012509 ChaB; Region: ChaB; cl01887 1173027012510 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012512 active site 1173027012513 phosphorylation site [posttranslational modification] 1173027012514 intermolecular recognition site; other site 1173027012515 dimerization interface [polypeptide binding]; other site 1173027012516 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1173027012517 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1173027012518 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1173027012519 catalytic residue [active] 1173027012520 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027012521 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173027012522 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173027012523 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173027012524 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1173027012525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027012526 ATP binding site [chemical binding]; other site 1173027012527 putative Mg++ binding site [ion binding]; other site 1173027012528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027012529 nucleotide binding region [chemical binding]; other site 1173027012530 ATP-binding site [chemical binding]; other site 1173027012531 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027012532 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173027012533 legume lectins; Region: lectin_L-type; cl14058 1173027012534 homotetramer interaction site [polypeptide binding]; other site 1173027012535 carbohydrate binding site [chemical binding]; other site 1173027012536 metal binding site [ion binding]; metal-binding site 1173027012537 Domain of unknown function DUF11; Region: DUF11; cl17728 1173027012538 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1173027012539 dimer interface [polypeptide binding]; other site 1173027012540 catalytic triad [active] 1173027012541 DAK2 domain; Region: Dak2; cl03685 1173027012542 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1173027012543 active site 1173027012544 catalytic triad [active] 1173027012545 oxyanion hole [active] 1173027012546 elongation factor G; Reviewed; Region: PRK00007 1173027012547 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1173027012548 G1 box; other site 1173027012549 putative GEF interaction site [polypeptide binding]; other site 1173027012550 GTP/Mg2+ binding site [chemical binding]; other site 1173027012551 Switch I region; other site 1173027012552 G2 box; other site 1173027012553 G3 box; other site 1173027012554 Switch II region; other site 1173027012555 G4 box; other site 1173027012556 G5 box; other site 1173027012557 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 1173027012558 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173027012559 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173027012560 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027012561 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173027012562 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1173027012563 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173027012564 Putative phosphatase (DUF442); Region: DUF442; cl17385 1173027012565 Acylphosphatase; Region: Acylphosphatase; cl00551 1173027012566 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1173027012567 Cysteine-rich domain; Region: CCG; pfam02754 1173027012568 Cysteine-rich domain; Region: CCG; pfam02754 1173027012569 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173027012570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027012571 NAD(P) binding site [chemical binding]; other site 1173027012572 active site 1173027012573 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1173027012574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027012575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027012576 homodimer interface [polypeptide binding]; other site 1173027012577 catalytic residue [active] 1173027012578 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173027012579 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027012580 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173027012581 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173027012582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027012583 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027012584 active site 1173027012585 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027012586 active site 1173027012587 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027012588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027012589 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027012590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027012591 active site 1173027012592 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173027012593 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173027012594 iron-sulfur cluster [ion binding]; other site 1173027012595 [2Fe-2S] cluster binding site [ion binding]; other site 1173027012596 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1173027012597 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173027012598 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173027012599 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173027012600 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173027012601 NAD binding site [chemical binding]; other site 1173027012602 homodimer interface [polypeptide binding]; other site 1173027012603 active site 1173027012604 substrate binding site [chemical binding]; other site 1173027012605 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173027012606 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173027012607 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027012608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027012609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027012610 ligand binding site [chemical binding]; other site 1173027012611 flexible hinge region; other site 1173027012612 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173027012613 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173027012614 putative active site [active] 1173027012615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027012616 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173027012617 Walker A/P-loop; other site 1173027012618 ATP binding site [chemical binding]; other site 1173027012619 Q-loop/lid; other site 1173027012620 ABC transporter signature motif; other site 1173027012621 Walker B; other site 1173027012622 D-loop; other site 1173027012623 H-loop/switch region; other site 1173027012624 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173027012625 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1173027012626 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1173027012627 Peptidase family U32; Region: Peptidase_U32; pfam01136 1173027012628 Collagenase; Region: DUF3656; pfam12392 1173027012629 Peptidase family U32; Region: Peptidase_U32; cl03113 1173027012630 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027012631 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027012632 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1173027012633 putative catalytic site [active] 1173027012634 putative metal binding site [ion binding]; other site 1173027012635 putative phosphate binding site [ion binding]; other site 1173027012636 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1173027012637 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027012638 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012640 active site 1173027012641 phosphorylation site [posttranslational modification] 1173027012642 intermolecular recognition site; other site 1173027012643 dimerization interface [polypeptide binding]; other site 1173027012644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012645 PAS fold; Region: PAS_3; pfam08447 1173027012646 putative active site [active] 1173027012647 heme pocket [chemical binding]; other site 1173027012648 GAF domain; Region: GAF; pfam01590 1173027012649 GAF domain; Region: GAF_3; pfam13492 1173027012650 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012652 dimer interface [polypeptide binding]; other site 1173027012653 phosphorylation site [posttranslational modification] 1173027012654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012655 ATP binding site [chemical binding]; other site 1173027012656 Mg2+ binding site [ion binding]; other site 1173027012657 G-X-G motif; other site 1173027012658 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012660 active site 1173027012661 phosphorylation site [posttranslational modification] 1173027012662 intermolecular recognition site; other site 1173027012663 dimerization interface [polypeptide binding]; other site 1173027012664 CHASE3 domain; Region: CHASE3; pfam05227 1173027012665 PAS domain S-box; Region: sensory_box; TIGR00229 1173027012666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012667 putative active site [active] 1173027012668 heme pocket [chemical binding]; other site 1173027012669 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1173027012670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012671 putative active site [active] 1173027012672 heme pocket [chemical binding]; other site 1173027012673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012674 dimer interface [polypeptide binding]; other site 1173027012675 phosphorylation site [posttranslational modification] 1173027012676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012677 ATP binding site [chemical binding]; other site 1173027012678 Mg2+ binding site [ion binding]; other site 1173027012679 G-X-G motif; other site 1173027012680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012681 putative active site [active] 1173027012682 PAS fold; Region: PAS_3; pfam08447 1173027012683 heme pocket [chemical binding]; other site 1173027012684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012685 PAS fold; Region: PAS_3; pfam08447 1173027012686 putative active site [active] 1173027012687 heme pocket [chemical binding]; other site 1173027012688 GAF domain; Region: GAF; pfam01590 1173027012689 GAF domain; Region: GAF; pfam01590 1173027012690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012691 dimer interface [polypeptide binding]; other site 1173027012692 phosphorylation site [posttranslational modification] 1173027012693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012694 ATP binding site [chemical binding]; other site 1173027012695 Mg2+ binding site [ion binding]; other site 1173027012696 G-X-G motif; other site 1173027012697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027012698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012699 active site 1173027012700 phosphorylation site [posttranslational modification] 1173027012701 intermolecular recognition site; other site 1173027012702 dimerization interface [polypeptide binding]; other site 1173027012703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027012704 DNA binding residues [nucleotide binding] 1173027012705 dimerization interface [polypeptide binding]; other site 1173027012706 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012708 active site 1173027012709 phosphorylation site [posttranslational modification] 1173027012710 intermolecular recognition site; other site 1173027012711 dimerization interface [polypeptide binding]; other site 1173027012712 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012714 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027012715 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027012716 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173027012717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173027012718 ATP binding site [chemical binding]; other site 1173027012719 Mg2+ binding site [ion binding]; other site 1173027012720 G-X-G motif; other site 1173027012721 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173027012722 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173027012723 Transposase IS200 like; Region: Y1_Tnp; cl00848 1173027012724 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1173027012725 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027012726 G1 box; other site 1173027012727 GTP/Mg2+ binding site [chemical binding]; other site 1173027012728 GAF domain; Region: GAF_2; pfam13185 1173027012729 GAF domain; Region: GAF; cl17456 1173027012730 Nitrate and nitrite sensing; Region: NIT; pfam08376 1173027012731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012732 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027012733 putative active site [active] 1173027012734 heme pocket [chemical binding]; other site 1173027012735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012736 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027012737 putative active site [active] 1173027012738 heme pocket [chemical binding]; other site 1173027012739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027012740 dimer interface [polypeptide binding]; other site 1173027012741 phosphorylation site [posttranslational modification] 1173027012742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027012743 ATP binding site [chemical binding]; other site 1173027012744 Mg2+ binding site [ion binding]; other site 1173027012745 G-X-G motif; other site 1173027012746 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012748 active site 1173027012749 phosphorylation site [posttranslational modification] 1173027012750 intermolecular recognition site; other site 1173027012751 dimerization interface [polypeptide binding]; other site 1173027012752 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012754 active site 1173027012755 phosphorylation site [posttranslational modification] 1173027012756 intermolecular recognition site; other site 1173027012757 dimerization interface [polypeptide binding]; other site 1173027012758 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027012759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012760 active site 1173027012761 phosphorylation site [posttranslational modification] 1173027012762 intermolecular recognition site; other site 1173027012763 dimerization interface [polypeptide binding]; other site 1173027012764 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027012765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027012766 active site 1173027012767 phosphorylation site [posttranslational modification] 1173027012768 intermolecular recognition site; other site 1173027012769 dimerization interface [polypeptide binding]; other site 1173027012770 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027012771 cyclase homology domain; Region: CHD; cd07302 1173027012772 nucleotidyl binding site; other site 1173027012773 metal binding site [ion binding]; metal-binding site 1173027012774 dimer interface [polypeptide binding]; other site 1173027012775 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 1173027012776 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027012777 Maf-like protein; Region: Maf; pfam02545 1173027012778 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1173027012779 active site 1173027012780 dimer interface [polypeptide binding]; other site 1173027012781 PsbP; Region: PsbP; pfam01789 1173027012782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012783 binding surface 1173027012784 TPR motif; other site 1173027012785 TPR repeat; Region: TPR_11; pfam13414 1173027012786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012787 binding surface 1173027012788 TPR motif; other site 1173027012789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012790 binding surface 1173027012791 TPR repeat; Region: TPR_11; pfam13414 1173027012792 TPR motif; other site 1173027012793 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027012794 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027012795 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173027012796 Hexamer interface [polypeptide binding]; other site 1173027012797 Hexagonal pore residue; other site 1173027012798 OstA-like protein; Region: OstA; cl00844 1173027012799 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 1173027012800 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 1173027012801 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173027012802 putative homodimer interface [polypeptide binding]; other site 1173027012803 putative active site pocket [active] 1173027012804 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173027012805 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027012806 CHASE2 domain; Region: CHASE2; pfam05226 1173027012807 Protein kinase domain; Region: Pkinase; pfam00069 1173027012808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012809 active site 1173027012810 ATP binding site [chemical binding]; other site 1173027012811 substrate binding site [chemical binding]; other site 1173027012812 activation loop (A-loop); other site 1173027012813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012815 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027012816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027012817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027012818 PAS domain; Region: PAS_9; pfam13426 1173027012819 putative active site [active] 1173027012820 heme pocket [chemical binding]; other site 1173027012821 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027012822 cyclase homology domain; Region: CHD; cd07302 1173027012823 nucleotidyl binding site; other site 1173027012824 metal binding site [ion binding]; metal-binding site 1173027012825 dimer interface [polypeptide binding]; other site 1173027012826 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1173027012827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027012828 Walker A/P-loop; other site 1173027012829 ATP binding site [chemical binding]; other site 1173027012830 Q-loop/lid; other site 1173027012831 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1173027012832 ABC transporter signature motif; other site 1173027012833 Walker B; other site 1173027012834 D-loop; other site 1173027012835 H-loop/switch region; other site 1173027012836 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027012837 ABC1 family; Region: ABC1; pfam03109 1173027012838 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173027012839 active site 1173027012840 ATP binding site [chemical binding]; other site 1173027012841 protein kinase A catalytic subunit; Provisional; Region: PTZ00263 1173027012842 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012843 active site 1173027012844 ATP binding site [chemical binding]; other site 1173027012845 substrate binding site [chemical binding]; other site 1173027012846 activation loop (A-loop); other site 1173027012847 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027012848 structural tetrad; other site 1173027012849 PQQ-like domain; Region: PQQ_2; pfam13360 1173027012850 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1173027012851 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027012852 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027012853 Double zinc ribbon; Region: DZR; pfam12773 1173027012854 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173027012855 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027012856 active site 1173027012857 ATP binding site [chemical binding]; other site 1173027012858 substrate binding site [chemical binding]; other site 1173027012859 activation loop (A-loop); other site 1173027012860 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027012861 structural tetrad; other site 1173027012862 PQQ-like domain; Region: PQQ_2; pfam13360 1173027012863 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027012864 TPR repeat; Region: TPR_11; pfam13414 1173027012865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027012866 binding surface 1173027012867 TPR motif; other site 1173027012868 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027012869 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027012870 structural tetrad; other site 1173027012871 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 1173027012872 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1173027012873 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027012874 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173027012875 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173027012876 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027012877 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027012878 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173027012879 Hexamer interface [polypeptide binding]; other site 1173027012880 Hexagonal pore residue; other site 1173027012881 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027012882 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173027012883 Hexamer interface [polypeptide binding]; other site 1173027012884 Hexagonal pore residue; other site 1173027012885 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1173027012886 Hexamer/Pentamer interface [polypeptide binding]; other site 1173027012887 central pore; other site 1173027012888 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173027012889 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173027012890 trimer interface [polypeptide binding]; other site 1173027012891 active site 1173027012892 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173027012893 putative multimerization interface [polypeptide binding]; other site 1173027012894 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173027012895 putative multimerization interface [polypeptide binding]; other site 1173027012896 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173027012897 putative multimerization interface [polypeptide binding]; other site 1173027012898 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173027012899 putative trimer interface [polypeptide binding]; other site 1173027012900 putative CoA binding site [chemical binding]; other site 1173027012901 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027012902 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173027012903 Hexamer interface [polypeptide binding]; other site 1173027012904 Hexagonal pore residue; other site 1173027012905 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173027012906 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173027012907 Hexamer interface [polypeptide binding]; other site 1173027012908 Hexagonal pore residue; other site 1173027012909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027012910 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1173027012911 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1173027012912 putative dimerization interface [polypeptide binding]; other site 1173027012913 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173027012914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027012915 dimer interface [polypeptide binding]; other site 1173027012916 conserved gate region; other site 1173027012917 putative PBP binding loops; other site 1173027012918 ABC-ATPase subunit interface; other site 1173027012919 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1173027012920 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027012921 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1173027012922 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1173027012923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027012924 non-specific DNA binding site [nucleotide binding]; other site 1173027012925 salt bridge; other site 1173027012926 sequence-specific DNA binding site [nucleotide binding]; other site 1173027012927 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1173027012928 putative active site [active] 1173027012929 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 1173027012930 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1173027012931 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1173027012932 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1173027012933 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1173027012934 dimer interface [polypeptide binding]; other site 1173027012935 motif 1; other site 1173027012936 active site 1173027012937 motif 2; other site 1173027012938 motif 3; other site 1173027012939 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173027012940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027012941 Zn2+ binding site [ion binding]; other site 1173027012942 Mg2+ binding site [ion binding]; other site 1173027012943 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1173027012944 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1173027012945 HflX GTPase family; Region: HflX; cd01878 1173027012946 G1 box; other site 1173027012947 GTP/Mg2+ binding site [chemical binding]; other site 1173027012948 Switch I region; other site 1173027012949 G2 box; other site 1173027012950 G3 box; other site 1173027012951 Switch II region; other site 1173027012952 G4 box; other site 1173027012953 G5 box; other site 1173027012954 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173027012955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027012956 Walker A/P-loop; other site 1173027012957 ATP binding site [chemical binding]; other site 1173027012958 Q-loop/lid; other site 1173027012959 ABC transporter signature motif; other site 1173027012960 Walker B; other site 1173027012961 D-loop; other site 1173027012962 H-loop/switch region; other site 1173027012963 ABC transporter; Region: ABC_tran_2; pfam12848 1173027012964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173027012965 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027012966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027012967 S-adenosylmethionine binding site [chemical binding]; other site 1173027012968 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1173027012969 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1173027012970 active site 1173027012971 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1173027012972 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173027012973 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027012974 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173027012975 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173027012976 GxxExxY protein; Region: GxxExxY; TIGR04256 1173027012977 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027012978 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027012979 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027012980 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173027012981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027012982 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173027012983 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027012984 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 1173027012985 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027012986 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027012987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173027012988 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1173027012989 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173027012990 Serine hydrolase; Region: Ser_hydrolase; cl17834 1173027012991 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173027012992 nudix motif; other site 1173027012993 argininosuccinate lyase; Provisional; Region: PRK00855 1173027012994 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1173027012995 active sites [active] 1173027012996 tetramer interface [polypeptide binding]; other site 1173027012997 GAF domain; Region: GAF_3; pfam13492 1173027012998 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027012999 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027013000 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1173027013001 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1173027013002 Mg++ binding site [ion binding]; other site 1173027013003 putative catalytic motif [active] 1173027013004 putative substrate binding site [chemical binding]; other site 1173027013005 Cache domain; Region: Cache_1; pfam02743 1173027013006 PAS domain S-box; Region: sensory_box; TIGR00229 1173027013007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013008 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013009 putative active site [active] 1173027013010 heme pocket [chemical binding]; other site 1173027013011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013012 putative active site [active] 1173027013013 heme pocket [chemical binding]; other site 1173027013014 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013015 GAF domain; Region: GAF; pfam01590 1173027013016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013018 dimer interface [polypeptide binding]; other site 1173027013019 phosphorylation site [posttranslational modification] 1173027013020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013021 ATP binding site [chemical binding]; other site 1173027013022 Mg2+ binding site [ion binding]; other site 1173027013023 G-X-G motif; other site 1173027013024 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013026 active site 1173027013027 phosphorylation site [posttranslational modification] 1173027013028 intermolecular recognition site; other site 1173027013029 dimerization interface [polypeptide binding]; other site 1173027013030 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013032 active site 1173027013033 phosphorylation site [posttranslational modification] 1173027013034 intermolecular recognition site; other site 1173027013035 dimerization interface [polypeptide binding]; other site 1173027013036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013037 PAS domain; Region: PAS_9; pfam13426 1173027013038 putative active site [active] 1173027013039 heme pocket [chemical binding]; other site 1173027013040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027013041 dimer interface [polypeptide binding]; other site 1173027013042 phosphorylation site [posttranslational modification] 1173027013043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013044 ATP binding site [chemical binding]; other site 1173027013045 Mg2+ binding site [ion binding]; other site 1173027013046 G-X-G motif; other site 1173027013047 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1173027013048 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1173027013049 N- and C-terminal domain interface [polypeptide binding]; other site 1173027013050 active site 1173027013051 catalytic site [active] 1173027013052 metal binding site [ion binding]; metal-binding site 1173027013053 carbohydrate binding site [chemical binding]; other site 1173027013054 ATP binding site [chemical binding]; other site 1173027013055 Predicted membrane protein [Function unknown]; Region: COG4330 1173027013056 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173027013057 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1173027013058 substrate binding site; other site 1173027013059 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1173027013060 active site 1173027013061 nucleophile elbow; other site 1173027013062 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1173027013063 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 1173027013064 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1173027013065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027013066 NAD(P) binding site [chemical binding]; other site 1173027013067 active site 1173027013068 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1173027013069 putative active site [active] 1173027013070 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1173027013071 DNA protecting protein DprA; Region: dprA; TIGR00732 1173027013072 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1173027013073 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1173027013074 active site 1173027013075 catalytic site [active] 1173027013076 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1173027013077 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 1173027013078 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 1173027013079 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 1173027013080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027013081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013082 active site 1173027013083 phosphorylation site [posttranslational modification] 1173027013084 intermolecular recognition site; other site 1173027013085 dimerization interface [polypeptide binding]; other site 1173027013086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027013087 DNA binding site [nucleotide binding] 1173027013088 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1173027013089 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173027013090 classical (c) SDRs; Region: SDR_c; cd05233 1173027013091 NAD(P) binding site [chemical binding]; other site 1173027013092 active site 1173027013093 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1173027013094 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173027013095 Walker A/P-loop; other site 1173027013096 ATP binding site [chemical binding]; other site 1173027013097 Q-loop/lid; other site 1173027013098 ABC transporter signature motif; other site 1173027013099 Walker B; other site 1173027013100 D-loop; other site 1173027013101 H-loop/switch region; other site 1173027013102 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1173027013103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027013104 dimer interface [polypeptide binding]; other site 1173027013105 conserved gate region; other site 1173027013106 putative PBP binding loops; other site 1173027013107 ABC-ATPase subunit interface; other site 1173027013108 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173027013109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027013110 dimer interface [polypeptide binding]; other site 1173027013111 conserved gate region; other site 1173027013112 putative PBP binding loops; other site 1173027013113 ABC-ATPase subunit interface; other site 1173027013114 PBP superfamily domain; Region: PBP_like_2; cl17296 1173027013115 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173027013116 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173027013117 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173027013118 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173027013119 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173027013120 LabA_like proteins; Region: LabA_like; cd06167 1173027013121 putative metal binding site [ion binding]; other site 1173027013122 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1173027013123 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173027013124 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173027013125 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173027013126 classical (c) SDRs; Region: SDR_c; cd05233 1173027013127 NAD(P) binding site [chemical binding]; other site 1173027013128 active site 1173027013129 Protein of unknown function DUF99; Region: DUF99; pfam01949 1173027013130 hypothetical protein; Provisional; Region: PRK00766 1173027013131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013133 ATP binding site [chemical binding]; other site 1173027013134 G-X-G motif; other site 1173027013135 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173027013136 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027013137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027013138 catalytic residue [active] 1173027013139 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173027013140 putative active site pocket [active] 1173027013141 dimerization interface [polypeptide binding]; other site 1173027013142 putative catalytic residue [active] 1173027013143 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1173027013144 CoA binding domain; Region: CoA_binding_2; pfam13380 1173027013145 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1173027013146 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1173027013147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027013148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027013149 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027013150 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 1173027013151 CP12 domain; Region: CP12; pfam02672 1173027013152 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1173027013153 putative active site [active] 1173027013154 dimerization interface [polypeptide binding]; other site 1173027013155 putative tRNAtyr binding site [nucleotide binding]; other site 1173027013156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013158 active site 1173027013159 phosphorylation site [posttranslational modification] 1173027013160 intermolecular recognition site; other site 1173027013161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013162 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013163 putative active site [active] 1173027013164 heme pocket [chemical binding]; other site 1173027013165 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013167 putative active site [active] 1173027013168 heme pocket [chemical binding]; other site 1173027013169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013170 putative active site [active] 1173027013171 heme pocket [chemical binding]; other site 1173027013172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013173 PAS domain; Region: PAS_9; pfam13426 1173027013174 putative active site [active] 1173027013175 heme pocket [chemical binding]; other site 1173027013176 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013177 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013180 ATP binding site [chemical binding]; other site 1173027013181 Mg2+ binding site [ion binding]; other site 1173027013182 G-X-G motif; other site 1173027013183 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173027013184 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173027013185 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173027013186 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1173027013187 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173027013188 active site 1173027013189 HIGH motif; other site 1173027013190 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173027013191 KMSKS motif; other site 1173027013192 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1173027013193 tRNA binding surface [nucleotide binding]; other site 1173027013194 anticodon binding site; other site 1173027013195 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1173027013196 Cache domain; Region: Cache_1; pfam02743 1173027013197 HAMP domain; Region: HAMP; pfam00672 1173027013198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013199 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013200 putative active site [active] 1173027013201 heme pocket [chemical binding]; other site 1173027013202 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173027013203 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027013204 cyclase homology domain; Region: CHD; cd07302 1173027013205 nucleotidyl binding site; other site 1173027013206 metal binding site [ion binding]; metal-binding site 1173027013207 dimer interface [polypeptide binding]; other site 1173027013208 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1173027013209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013211 dimer interface [polypeptide binding]; other site 1173027013212 phosphorylation site [posttranslational modification] 1173027013213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013214 ATP binding site [chemical binding]; other site 1173027013215 Mg2+ binding site [ion binding]; other site 1173027013216 G-X-G motif; other site 1173027013217 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013219 active site 1173027013220 phosphorylation site [posttranslational modification] 1173027013221 intermolecular recognition site; other site 1173027013222 dimerization interface [polypeptide binding]; other site 1173027013223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013225 putative active site [active] 1173027013226 heme pocket [chemical binding]; other site 1173027013227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013228 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013229 putative active site [active] 1173027013230 heme pocket [chemical binding]; other site 1173027013231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013232 putative active site [active] 1173027013233 heme pocket [chemical binding]; other site 1173027013234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013235 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013236 putative active site [active] 1173027013237 heme pocket [chemical binding]; other site 1173027013238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013239 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027013240 putative active site [active] 1173027013241 heme pocket [chemical binding]; other site 1173027013242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013243 dimer interface [polypeptide binding]; other site 1173027013244 phosphorylation site [posttranslational modification] 1173027013245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013246 ATP binding site [chemical binding]; other site 1173027013247 Mg2+ binding site [ion binding]; other site 1173027013248 G-X-G motif; other site 1173027013249 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013251 active site 1173027013252 phosphorylation site [posttranslational modification] 1173027013253 intermolecular recognition site; other site 1173027013254 dimerization interface [polypeptide binding]; other site 1173027013255 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1173027013256 AMIN domain; Region: AMIN; pfam11741 1173027013257 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173027013258 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173027013259 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173027013260 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173027013261 dimer interface [polypeptide binding]; other site 1173027013262 ssDNA binding site [nucleotide binding]; other site 1173027013263 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027013264 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173027013265 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173027013266 active site 1173027013267 Substrate binding site; other site 1173027013268 Mg++ binding site; other site 1173027013269 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173027013270 putative trimer interface [polypeptide binding]; other site 1173027013271 putative CoA binding site [chemical binding]; other site 1173027013272 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173027013273 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1173027013274 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1173027013275 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1173027013276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027013277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027013278 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1173027013279 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173027013280 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1173027013281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027013282 Walker A motif; other site 1173027013283 ATP binding site [chemical binding]; other site 1173027013284 Walker B motif; other site 1173027013285 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1173027013286 Clp protease; Region: CLP_protease; pfam00574 1173027013287 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173027013288 oligomer interface [polypeptide binding]; other site 1173027013289 active site residues [active] 1173027013290 trigger factor; Provisional; Region: tig; PRK01490 1173027013291 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173027013292 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1173027013293 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1173027013294 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173027013295 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1173027013296 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1173027013297 dimer interface [polypeptide binding]; other site 1173027013298 active site 1173027013299 catalytic residue [active] 1173027013300 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1173027013301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173027013302 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173027013303 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173027013304 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1173027013305 MltA specific insert domain; Region: MltA; pfam03562 1173027013306 3D domain; Region: 3D; pfam06725 1173027013307 Resolvase, N terminal domain; Region: Resolvase; smart00857 1173027013308 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173027013309 Recombinase; Region: Recombinase; pfam07508 1173027013310 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1173027013311 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1173027013312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027013313 dimer interface [polypeptide binding]; other site 1173027013314 putative metal binding site [ion binding]; other site 1173027013315 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1173027013316 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173027013317 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173027013318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027013319 dimer interface [polypeptide binding]; other site 1173027013320 conserved gate region; other site 1173027013321 putative PBP binding loops; other site 1173027013322 ABC-ATPase subunit interface; other site 1173027013323 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173027013324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027013325 dimer interface [polypeptide binding]; other site 1173027013326 conserved gate region; other site 1173027013327 putative PBP binding loops; other site 1173027013328 ABC-ATPase subunit interface; other site 1173027013329 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013330 GAF domain; Region: GAF; pfam01590 1173027013331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013332 dimer interface [polypeptide binding]; other site 1173027013333 phosphorylation site [posttranslational modification] 1173027013334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013335 ATP binding site [chemical binding]; other site 1173027013336 Mg2+ binding site [ion binding]; other site 1173027013337 G-X-G motif; other site 1173027013338 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013340 active site 1173027013341 phosphorylation site [posttranslational modification] 1173027013342 intermolecular recognition site; other site 1173027013343 dimerization interface [polypeptide binding]; other site 1173027013344 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013346 active site 1173027013347 phosphorylation site [posttranslational modification] 1173027013348 intermolecular recognition site; other site 1173027013349 dimerization interface [polypeptide binding]; other site 1173027013350 PAS domain S-box; Region: sensory_box; TIGR00229 1173027013351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013352 putative active site [active] 1173027013353 heme pocket [chemical binding]; other site 1173027013354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013355 PAS fold; Region: PAS_3; pfam08447 1173027013356 putative active site [active] 1173027013357 heme pocket [chemical binding]; other site 1173027013358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013359 dimer interface [polypeptide binding]; other site 1173027013360 phosphorylation site [posttranslational modification] 1173027013361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013363 ATP binding site [chemical binding]; other site 1173027013364 G-X-G motif; other site 1173027013365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013367 active site 1173027013368 phosphorylation site [posttranslational modification] 1173027013369 intermolecular recognition site; other site 1173027013370 dimerization interface [polypeptide binding]; other site 1173027013371 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1173027013372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027013373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027013374 dimer interface [polypeptide binding]; other site 1173027013375 putative CheW interface [polypeptide binding]; other site 1173027013376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027013377 putative binding surface; other site 1173027013378 active site 1173027013379 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027013380 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027013381 putative binding surface; other site 1173027013382 active site 1173027013383 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027013384 putative binding surface; other site 1173027013385 active site 1173027013386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013387 ATP binding site [chemical binding]; other site 1173027013388 Mg2+ binding site [ion binding]; other site 1173027013389 G-X-G motif; other site 1173027013390 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027013391 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013393 active site 1173027013394 phosphorylation site [posttranslational modification] 1173027013395 intermolecular recognition site; other site 1173027013396 dimerization interface [polypeptide binding]; other site 1173027013397 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1173027013398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013399 active site 1173027013400 phosphorylation site [posttranslational modification] 1173027013401 intermolecular recognition site; other site 1173027013402 dimerization interface [polypeptide binding]; other site 1173027013403 CheB methylesterase; Region: CheB_methylest; pfam01339 1173027013404 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173027013405 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173027013406 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173027013407 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1173027013408 aspartate aminotransferase; Provisional; Region: PRK05957 1173027013409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027013410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027013411 homodimer interface [polypeptide binding]; other site 1173027013412 catalytic residue [active] 1173027013413 Predicted membrane protein [Function unknown]; Region: COG4244 1173027013414 Predicted membrane protein [Function unknown]; Region: COG4244 1173027013415 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1173027013416 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173027013417 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173027013418 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1173027013419 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173027013420 Subunit I/III interface [polypeptide binding]; other site 1173027013421 Protein kinase domain; Region: Pkinase; pfam00069 1173027013422 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027013423 active site 1173027013424 ATP binding site [chemical binding]; other site 1173027013425 substrate binding site [chemical binding]; other site 1173027013426 activation loop (A-loop); other site 1173027013427 AAA ATPase domain; Region: AAA_16; pfam13191 1173027013428 Predicted ATPase [General function prediction only]; Region: COG3899 1173027013429 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013430 GAF domain; Region: GAF; pfam01590 1173027013431 PAS fold; Region: PAS_4; pfam08448 1173027013432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013433 putative active site [active] 1173027013434 heme pocket [chemical binding]; other site 1173027013435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013437 dimer interface [polypeptide binding]; other site 1173027013438 phosphorylation site [posttranslational modification] 1173027013439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013440 ATP binding site [chemical binding]; other site 1173027013441 Mg2+ binding site [ion binding]; other site 1173027013442 G-X-G motif; other site 1173027013443 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173027013444 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1173027013445 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1173027013446 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1173027013447 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027013448 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027013449 CHAT domain; Region: CHAT; cl17868 1173027013450 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1173027013451 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173027013452 Mg binding site [ion binding]; other site 1173027013453 nucleotide binding site [chemical binding]; other site 1173027013454 putative protofilament interface [polypeptide binding]; other site 1173027013455 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173027013456 catalytic motif [active] 1173027013457 Catalytic residue [active] 1173027013458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027013459 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027013460 GTPase Era; Reviewed; Region: era; PRK00089 1173027013461 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1173027013462 G1 box; other site 1173027013463 GTP/Mg2+ binding site [chemical binding]; other site 1173027013464 Switch I region; other site 1173027013465 G2 box; other site 1173027013466 Switch II region; other site 1173027013467 G3 box; other site 1173027013468 G4 box; other site 1173027013469 G5 box; other site 1173027013470 KH domain; Region: KH_2; pfam07650 1173027013471 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1173027013472 Putative zinc-finger; Region: zf-HC2; pfam13490 1173027013473 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1173027013474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027013475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027013476 DNA binding residues [nucleotide binding] 1173027013477 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013479 active site 1173027013480 phosphorylation site [posttranslational modification] 1173027013481 intermolecular recognition site; other site 1173027013482 dimerization interface [polypeptide binding]; other site 1173027013483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173027013484 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173027013485 Late competence development protein ComFB; Region: ComFB; pfam10719 1173027013486 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173027013487 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173027013488 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173027013489 putative cation:proton antiport protein; Provisional; Region: PRK10669 1173027013490 TrkA-N domain; Region: TrkA_N; pfam02254 1173027013491 TrkA-C domain; Region: TrkA_C; pfam02080 1173027013492 TrkA-C domain; Region: TrkA_C; pfam02080 1173027013493 Sm and related proteins; Region: Sm_like; cl00259 1173027013494 heptamer interface [polypeptide binding]; other site 1173027013495 Sm1 motif; other site 1173027013496 hexamer interface [polypeptide binding]; other site 1173027013497 RNA binding site [nucleotide binding]; other site 1173027013498 Sm2 motif; other site 1173027013499 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173027013500 diaminopimelate epimerase; Region: PLN02536 1173027013501 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173027013502 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173027013503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173027013504 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027013505 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027013506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173027013507 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027013508 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1173027013509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173027013510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013511 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027013512 putative active site [active] 1173027013513 heme pocket [chemical binding]; other site 1173027013514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013515 PAS fold; Region: PAS_4; pfam08448 1173027013516 putative active site [active] 1173027013517 heme pocket [chemical binding]; other site 1173027013518 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013519 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013520 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013521 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013523 dimer interface [polypeptide binding]; other site 1173027013524 phosphorylation site [posttranslational modification] 1173027013525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013526 ATP binding site [chemical binding]; other site 1173027013527 Mg2+ binding site [ion binding]; other site 1173027013528 G-X-G motif; other site 1173027013529 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013531 active site 1173027013532 phosphorylation site [posttranslational modification] 1173027013533 intermolecular recognition site; other site 1173027013534 dimerization interface [polypeptide binding]; other site 1173027013535 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013537 active site 1173027013538 phosphorylation site [posttranslational modification] 1173027013539 intermolecular recognition site; other site 1173027013540 dimerization interface [polypeptide binding]; other site 1173027013541 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027013542 putative binding surface; other site 1173027013543 active site 1173027013544 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027013545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027013546 active site 1173027013547 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027013548 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027013549 active site 1173027013550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027013551 dimerization interface [polypeptide binding]; other site 1173027013552 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013553 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013555 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013556 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027013557 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027013558 dimer interface [polypeptide binding]; other site 1173027013559 putative CheW interface [polypeptide binding]; other site 1173027013560 PAS fold; Region: PAS_4; pfam08448 1173027013561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013562 putative active site [active] 1173027013563 heme pocket [chemical binding]; other site 1173027013564 PAS domain S-box; Region: sensory_box; TIGR00229 1173027013565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013566 putative active site [active] 1173027013567 heme pocket [chemical binding]; other site 1173027013568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013569 PAS domain; Region: PAS_9; pfam13426 1173027013570 putative active site [active] 1173027013571 heme pocket [chemical binding]; other site 1173027013572 PAS fold; Region: PAS_4; pfam08448 1173027013573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013574 putative active site [active] 1173027013575 heme pocket [chemical binding]; other site 1173027013576 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1173027013577 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1173027013578 GTP/Mg2+ binding site [chemical binding]; other site 1173027013579 G4 box; other site 1173027013580 G5 box; other site 1173027013581 G1 box; other site 1173027013582 Switch I region; other site 1173027013583 G2 box; other site 1173027013584 G3 box; other site 1173027013585 Switch II region; other site 1173027013586 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027013587 Ligand Binding Site [chemical binding]; other site 1173027013588 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1173027013589 Phosphoglycerate kinase; Region: PGK; pfam00162 1173027013590 substrate binding site [chemical binding]; other site 1173027013591 hinge regions; other site 1173027013592 ADP binding site [chemical binding]; other site 1173027013593 catalytic site [active] 1173027013594 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1173027013595 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1173027013596 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1173027013597 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1173027013598 active site 1173027013599 Zn binding site [ion binding]; other site 1173027013600 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173027013601 catalytic core [active] 1173027013602 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027013603 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173027013604 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027013605 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027013606 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027013607 putative active site [active] 1173027013608 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1173027013609 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1173027013610 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027013611 dimerization interface [polypeptide binding]; other site 1173027013612 putative DNA binding site [nucleotide binding]; other site 1173027013613 putative Zn2+ binding site [ion binding]; other site 1173027013614 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1173027013615 putative ABC transporter; Region: ycf24; CHL00085 1173027013616 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1173027013617 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1173027013618 Walker A/P-loop; other site 1173027013619 ATP binding site [chemical binding]; other site 1173027013620 Q-loop/lid; other site 1173027013621 ABC transporter signature motif; other site 1173027013622 Walker B; other site 1173027013623 D-loop; other site 1173027013624 H-loop/switch region; other site 1173027013625 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1173027013626 FeS assembly protein SufD; Region: sufD; TIGR01981 1173027013627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173027013628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1173027013629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027013630 catalytic residue [active] 1173027013631 XisH protein; Region: XisH; pfam08814 1173027013632 XisI protein; Region: XisI; pfam08869 1173027013633 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027013634 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027013635 active site 1173027013636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027013637 non-specific DNA binding site [nucleotide binding]; other site 1173027013638 salt bridge; other site 1173027013639 sequence-specific DNA binding site [nucleotide binding]; other site 1173027013640 MAPEG family; Region: MAPEG; pfam01124 1173027013641 Predicted integral membrane protein [Function unknown]; Region: COG5500 1173027013642 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1173027013643 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1173027013644 PhoH-like protein; Region: PhoH; pfam02562 1173027013645 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1173027013646 KH domain; Region: KH_4; pfam13083 1173027013647 ribosomal protein S16; Region: rps16; CHL00005 1173027013648 signal recognition particle protein; Provisional; Region: PRK10867 1173027013649 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1173027013650 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173027013651 GTP binding site [chemical binding]; other site 1173027013652 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1173027013653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027013654 dimer interface [polypeptide binding]; other site 1173027013655 conserved gate region; other site 1173027013656 ABC-ATPase subunit interface; other site 1173027013657 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013659 active site 1173027013660 phosphorylation site [posttranslational modification] 1173027013661 intermolecular recognition site; other site 1173027013662 dimerization interface [polypeptide binding]; other site 1173027013663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027013664 S-adenosylmethionine binding site [chemical binding]; other site 1173027013665 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027013666 ligand binding site [chemical binding]; other site 1173027013667 flexible hinge region; other site 1173027013668 Transglycosylase; Region: Transgly; pfam00912 1173027013669 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173027013670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1173027013671 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1173027013672 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173027013673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027013674 FeS/SAM binding site; other site 1173027013675 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173027013676 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1173027013677 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1173027013678 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1173027013679 hypothetical protein; Provisional; Region: PRK04194 1173027013680 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1173027013681 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173027013682 PHP domain; Region: PHP; pfam02811 1173027013683 active site 1173027013684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173027013685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173027013686 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1173027013687 metal binding site [ion binding]; metal-binding site 1173027013688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027013689 active site 1173027013690 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 1173027013691 putative active site [active] 1173027013692 putative catalytic site [active] 1173027013693 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1173027013694 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1173027013695 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1173027013696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027013697 dimerization interface [polypeptide binding]; other site 1173027013698 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027013699 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027013700 active site 1173027013701 ATP binding site [chemical binding]; other site 1173027013702 substrate binding site [chemical binding]; other site 1173027013703 activation loop (A-loop); other site 1173027013704 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027013705 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027013706 phosphopeptide binding site; other site 1173027013707 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013708 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013709 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027013710 cyclase homology domain; Region: CHD; cd07302 1173027013711 nucleotidyl binding site; other site 1173027013712 metal binding site [ion binding]; metal-binding site 1173027013713 dimer interface [polypeptide binding]; other site 1173027013714 RNA polymerase sigma factor; Provisional; Region: PRK12518 1173027013715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027013716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027013717 DNA binding residues [nucleotide binding] 1173027013718 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1173027013719 dimer interface [polypeptide binding]; other site 1173027013720 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1173027013721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027013722 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1173027013723 heme-binding site [chemical binding]; other site 1173027013724 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1173027013725 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 1173027013726 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173027013727 trimer interface [polypeptide binding]; other site 1173027013728 active site 1173027013729 substrate binding site [chemical binding]; other site 1173027013730 CoA binding site [chemical binding]; other site 1173027013731 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027013732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027013733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027013734 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027013735 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1173027013736 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027013737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027013738 active site 1173027013739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027013740 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173027013741 S-layer homology domain; Region: SLH; pfam00395 1173027013742 S-layer homology domain; Region: SLH; pfam00395 1173027013743 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173027013744 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1173027013745 SLBB domain; Region: SLBB; pfam10531 1173027013746 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027013747 Chain length determinant protein; Region: Wzz; pfam02706 1173027013748 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027013749 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027013750 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1173027013751 putative rRNA binding site [nucleotide binding]; other site 1173027013752 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173027013753 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173027013754 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1173027013755 putative active site [active] 1173027013756 catalytic site [active] 1173027013757 NifU-like domain; Region: NifU; pfam01106 1173027013758 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 1173027013759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173027013760 PAS domain; Region: PAS_9; pfam13426 1173027013761 putative active site [active] 1173027013762 heme pocket [chemical binding]; other site 1173027013763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013764 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013766 dimer interface [polypeptide binding]; other site 1173027013767 phosphorylation site [posttranslational modification] 1173027013768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013769 ATP binding site [chemical binding]; other site 1173027013770 Mg2+ binding site [ion binding]; other site 1173027013771 G-X-G motif; other site 1173027013772 GTP-binding protein LepA; Provisional; Region: PRK05433 1173027013773 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1173027013774 G1 box; other site 1173027013775 putative GEF interaction site [polypeptide binding]; other site 1173027013776 GTP/Mg2+ binding site [chemical binding]; other site 1173027013777 Switch I region; other site 1173027013778 G2 box; other site 1173027013779 G3 box; other site 1173027013780 Switch II region; other site 1173027013781 G4 box; other site 1173027013782 G5 box; other site 1173027013783 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1173027013784 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1173027013785 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1173027013786 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1173027013787 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027013788 NAD binding site [chemical binding]; other site 1173027013789 putative substrate binding site 2 [chemical binding]; other site 1173027013790 putative substrate binding site 1 [chemical binding]; other site 1173027013791 active site 1173027013792 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1173027013793 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173027013794 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173027013795 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173027013796 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1173027013797 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1173027013798 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1173027013799 active site 1173027013800 catalytic triad [active] 1173027013801 oxyanion hole [active] 1173027013802 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013804 active site 1173027013805 phosphorylation site [posttranslational modification] 1173027013806 intermolecular recognition site; other site 1173027013807 dimerization interface [polypeptide binding]; other site 1173027013808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013809 dimer interface [polypeptide binding]; other site 1173027013810 phosphorylation site [posttranslational modification] 1173027013811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013812 ATP binding site [chemical binding]; other site 1173027013813 Mg2+ binding site [ion binding]; other site 1173027013814 G-X-G motif; other site 1173027013815 Protein kinase domain; Region: Pkinase; pfam00069 1173027013816 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027013817 active site 1173027013818 ATP binding site [chemical binding]; other site 1173027013819 substrate binding site [chemical binding]; other site 1173027013820 activation loop (A-loop); other site 1173027013821 AAA ATPase domain; Region: AAA_16; pfam13191 1173027013822 Predicted ATPase [General function prediction only]; Region: COG3899 1173027013823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027013824 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013825 PAS fold; Region: PAS_4; pfam08448 1173027013826 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173027013827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027013828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013829 dimer interface [polypeptide binding]; other site 1173027013830 phosphorylation site [posttranslational modification] 1173027013831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013832 ATP binding site [chemical binding]; other site 1173027013833 Mg2+ binding site [ion binding]; other site 1173027013834 G-X-G motif; other site 1173027013835 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 1173027013836 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1173027013837 pheophytin binding site; other site 1173027013838 chlorophyll binding site; other site 1173027013839 quinone binding site; other site 1173027013840 Fe binding site [ion binding]; other site 1173027013841 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1173027013842 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173027013843 Cellulose binding domain; Region: CBM_2; pfam00553 1173027013844 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173027013845 Uncharacterized conserved protein [Function unknown]; Region: COG4938 1173027013846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027013847 Walker A/P-loop; other site 1173027013848 ATP binding site [chemical binding]; other site 1173027013849 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 1173027013850 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027013851 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173027013852 YcfA-like protein; Region: YcfA; pfam07927 1173027013853 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027013854 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027013855 active site 1173027013856 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173027013857 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173027013858 ring oligomerisation interface [polypeptide binding]; other site 1173027013859 ATP/Mg binding site [chemical binding]; other site 1173027013860 stacking interactions; other site 1173027013861 hinge regions; other site 1173027013862 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1173027013863 oligomerisation interface [polypeptide binding]; other site 1173027013864 mobile loop; other site 1173027013865 roof hairpin; other site 1173027013866 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027013867 dimer interface [polypeptide binding]; other site 1173027013868 [2Fe-2S] cluster binding site [ion binding]; other site 1173027013869 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1173027013870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013871 active site 1173027013872 phosphorylation site [posttranslational modification] 1173027013873 intermolecular recognition site; other site 1173027013874 dimerization interface [polypeptide binding]; other site 1173027013875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027013876 DNA binding residues [nucleotide binding] 1173027013877 dimerization interface [polypeptide binding]; other site 1173027013878 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 1173027013879 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1173027013880 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1173027013881 dimer interface [polypeptide binding]; other site 1173027013882 active site 1173027013883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027013884 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1173027013885 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1173027013886 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173027013887 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1173027013888 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173027013889 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173027013890 NAD binding site [chemical binding]; other site 1173027013891 homodimer interface [polypeptide binding]; other site 1173027013892 active site 1173027013893 substrate binding site [chemical binding]; other site 1173027013894 Protein of function (DUF2518); Region: DUF2518; pfam10726 1173027013895 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1173027013896 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1173027013897 putative active site [active] 1173027013898 metal binding site [ion binding]; metal-binding site 1173027013899 aspartate aminotransferase; Provisional; Region: PRK05942 1173027013900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027013901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027013902 homodimer interface [polypeptide binding]; other site 1173027013903 catalytic residue [active] 1173027013904 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 1173027013905 serpin-like protein; Provisional; Region: PHA02660 1173027013906 reactive center loop; other site 1173027013907 MAPEG family; Region: MAPEG; pfam01124 1173027013908 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027013909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013910 active site 1173027013911 phosphorylation site [posttranslational modification] 1173027013912 intermolecular recognition site; other site 1173027013913 dimerization interface [polypeptide binding]; other site 1173027013914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027013915 PAS fold; Region: PAS_3; pfam08447 1173027013916 putative active site [active] 1173027013917 heme pocket [chemical binding]; other site 1173027013918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013919 dimer interface [polypeptide binding]; other site 1173027013920 phosphorylation site [posttranslational modification] 1173027013921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013922 ATP binding site [chemical binding]; other site 1173027013923 Mg2+ binding site [ion binding]; other site 1173027013924 G-X-G motif; other site 1173027013925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013926 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013927 active site 1173027013928 phosphorylation site [posttranslational modification] 1173027013929 intermolecular recognition site; other site 1173027013930 dimerization interface [polypeptide binding]; other site 1173027013931 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013933 active site 1173027013934 phosphorylation site [posttranslational modification] 1173027013935 intermolecular recognition site; other site 1173027013936 dimerization interface [polypeptide binding]; other site 1173027013937 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1173027013938 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027013939 Phytochrome region; Region: PHY; pfam00360 1173027013940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027013941 dimer interface [polypeptide binding]; other site 1173027013942 phosphorylation site [posttranslational modification] 1173027013943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027013944 ATP binding site [chemical binding]; other site 1173027013945 Mg2+ binding site [ion binding]; other site 1173027013946 G-X-G motif; other site 1173027013947 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027013948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027013949 active site 1173027013950 phosphorylation site [posttranslational modification] 1173027013951 intermolecular recognition site; other site 1173027013952 dimerization interface [polypeptide binding]; other site 1173027013953 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173027013954 EamA-like transporter family; Region: EamA; pfam00892 1173027013955 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027013956 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027013957 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1173027013958 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173027013959 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173027013960 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027013961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1173027013962 putative acyl-acceptor binding pocket; other site 1173027013963 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027013964 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027013965 active site 1173027013966 catalytic tetrad [active] 1173027013967 translation initiation factor IF-3; Region: infC; TIGR00168 1173027013968 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173027013969 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173027013970 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1173027013971 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173027013972 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1173027013973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027013974 Walker A/P-loop; other site 1173027013975 ATP binding site [chemical binding]; other site 1173027013976 Q-loop/lid; other site 1173027013977 ABC transporter signature motif; other site 1173027013978 Walker B; other site 1173027013979 D-loop; other site 1173027013980 H-loop/switch region; other site 1173027013981 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027013982 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173027013983 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173027013984 active site 1173027013985 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1173027013986 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1173027013987 substrate binding site [chemical binding]; other site 1173027013988 catalytic Zn binding site [ion binding]; other site 1173027013989 NAD binding site [chemical binding]; other site 1173027013990 structural Zn binding site [ion binding]; other site 1173027013991 dimer interface [polypeptide binding]; other site 1173027013992 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 1173027013993 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1173027013994 alpha subunit interface [polypeptide binding]; other site 1173027013995 TPP binding site [chemical binding]; other site 1173027013996 heterodimer interface [polypeptide binding]; other site 1173027013997 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173027013998 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1173027013999 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1173027014000 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1173027014001 Protein export membrane protein; Region: SecD_SecF; pfam02355 1173027014002 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173027014003 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1173027014004 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1173027014005 homodimer interface [polypeptide binding]; other site 1173027014006 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1173027014007 active site pocket [active] 1173027014008 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173027014009 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1173027014010 putative di-iron ligands [ion binding]; other site 1173027014011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027014012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027014013 dimer interface [polypeptide binding]; other site 1173027014014 conserved gate region; other site 1173027014015 putative PBP binding loops; other site 1173027014016 ABC-ATPase subunit interface; other site 1173027014017 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173027014018 dinuclear metal binding motif [ion binding]; other site 1173027014019 acyl-ACP reductase; Provisional; Region: PRK14982 1173027014020 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1173027014021 NAD(P) binding pocket [chemical binding]; other site 1173027014022 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1173027014023 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1173027014024 short chain dehydrogenase; Provisional; Region: PRK07454 1173027014025 classical (c) SDRs; Region: SDR_c; cd05233 1173027014026 NAD(P) binding site [chemical binding]; other site 1173027014027 active site 1173027014028 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173027014029 homodecamer interface [polypeptide binding]; other site 1173027014030 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173027014031 active site 1173027014032 putative catalytic site residues [active] 1173027014033 zinc binding site [ion binding]; other site 1173027014034 GTP-CH-I/GFRP interaction surface; other site 1173027014035 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027014036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014037 active site 1173027014038 phosphorylation site [posttranslational modification] 1173027014039 intermolecular recognition site; other site 1173027014040 dimerization interface [polypeptide binding]; other site 1173027014041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014042 PAS fold; Region: PAS_3; pfam08447 1173027014043 putative active site [active] 1173027014044 heme pocket [chemical binding]; other site 1173027014045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014046 dimer interface [polypeptide binding]; other site 1173027014047 phosphorylation site [posttranslational modification] 1173027014048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014049 ATP binding site [chemical binding]; other site 1173027014050 G-X-G motif; other site 1173027014051 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173027014052 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173027014053 Trp docking motif [polypeptide binding]; other site 1173027014054 PQQ-like domain; Region: PQQ_2; pfam13360 1173027014055 active site 1173027014056 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173027014057 Trp docking motif [polypeptide binding]; other site 1173027014058 active site 1173027014059 PQQ-like domain; Region: PQQ_2; pfam13360 1173027014060 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1173027014061 Trp docking motif [polypeptide binding]; other site 1173027014062 active site 1173027014063 PQQ-like domain; Region: PQQ_2; pfam13360 1173027014064 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1173027014065 Cadherin-like repeat domain of alpha dystroglycan; Region: Dystroglycan_repeat; cd11303 1173027014066 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 1173027014067 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027014068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027014069 phosphopeptide binding site; other site 1173027014070 recombinase A; Provisional; Region: recA; PRK09354 1173027014071 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1173027014072 hexamer interface [polypeptide binding]; other site 1173027014073 Walker A motif; other site 1173027014074 ATP binding site [chemical binding]; other site 1173027014075 Walker B motif; other site 1173027014076 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1173027014077 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1173027014078 generic binding surface II; other site 1173027014079 generic binding surface I; other site 1173027014080 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027014081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027014082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027014083 active site 1173027014084 ATP binding site [chemical binding]; other site 1173027014085 substrate binding site [chemical binding]; other site 1173027014086 activation loop (A-loop); other site 1173027014087 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027014088 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 1173027014089 NurA nuclease; Region: NurA; smart00933 1173027014090 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173027014091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027014092 Probable transposase; Region: OrfB_IS605; pfam01385 1173027014093 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027014094 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1173027014095 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173027014096 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173027014097 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173027014098 Ligand Binding Site [chemical binding]; other site 1173027014099 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027014100 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1173027014101 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173027014102 CHAT domain; Region: CHAT; cl17868 1173027014103 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027014104 CHASE2 domain; Region: CHASE2; pfam05226 1173027014105 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027014106 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1173027014107 catalytic site [active] 1173027014108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014109 binding surface 1173027014110 TPR motif; other site 1173027014111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027014113 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027014114 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027014115 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1173027014116 arsenical pump membrane protein; Provisional; Region: PRK15445 1173027014117 transmembrane helices; other site 1173027014118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014119 PAS domain; Region: PAS_9; pfam13426 1173027014120 putative active site [active] 1173027014121 heme pocket [chemical binding]; other site 1173027014122 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014124 putative active site [active] 1173027014125 heme pocket [chemical binding]; other site 1173027014126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014127 ATP binding site [chemical binding]; other site 1173027014128 Mg2+ binding site [ion binding]; other site 1173027014129 G-X-G motif; other site 1173027014130 threonine synthase; Reviewed; Region: PRK06721 1173027014131 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173027014132 homodimer interface [polypeptide binding]; other site 1173027014133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027014134 catalytic residue [active] 1173027014135 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1173027014136 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173027014137 ATP binding site [chemical binding]; other site 1173027014138 Mg++ binding site [ion binding]; other site 1173027014139 motif III; other site 1173027014140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027014141 nucleotide binding region [chemical binding]; other site 1173027014142 ATP-binding site [chemical binding]; other site 1173027014143 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1173027014144 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173027014145 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027014146 FeS/SAM binding site; other site 1173027014147 TRAM domain; Region: TRAM; pfam01938 1173027014148 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 1173027014149 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173027014150 substrate binding site [chemical binding]; other site 1173027014151 putative active site [active] 1173027014152 redox center [active] 1173027014153 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173027014154 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027014155 CHASE2 domain; Region: CHASE2; pfam05226 1173027014156 PAS fold; Region: PAS_4; pfam08448 1173027014157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014158 putative active site [active] 1173027014159 heme pocket [chemical binding]; other site 1173027014160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027014161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027014162 metal binding site [ion binding]; metal-binding site 1173027014163 active site 1173027014164 I-site; other site 1173027014165 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1173027014166 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027014167 putative active site [active] 1173027014168 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1173027014169 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1173027014170 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027014171 PAS fold; Region: PAS_4; pfam08448 1173027014172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014173 putative active site [active] 1173027014174 heme pocket [chemical binding]; other site 1173027014175 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014177 putative active site [active] 1173027014178 heme pocket [chemical binding]; other site 1173027014179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014180 PAS domain; Region: PAS_9; pfam13426 1173027014181 putative active site [active] 1173027014182 heme pocket [chemical binding]; other site 1173027014183 L-aspartate oxidase; Provisional; Region: PRK07395 1173027014184 L-aspartate oxidase; Provisional; Region: PRK06175 1173027014185 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173027014186 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1173027014187 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173027014188 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1173027014189 dimer interface [polypeptide binding]; other site 1173027014190 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173027014191 catalytic triad [active] 1173027014192 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027014193 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027014194 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027014195 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173027014196 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173027014197 dimer interface [polypeptide binding]; other site 1173027014198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027014199 catalytic residue [active] 1173027014200 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027014201 dimer interface [polypeptide binding]; other site 1173027014202 [2Fe-2S] cluster binding site [ion binding]; other site 1173027014203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014204 PAS fold; Region: PAS_3; pfam08447 1173027014205 putative active site [active] 1173027014206 heme pocket [chemical binding]; other site 1173027014207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014208 PAS fold; Region: PAS_3; pfam08447 1173027014209 putative active site [active] 1173027014210 heme pocket [chemical binding]; other site 1173027014211 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014213 putative active site [active] 1173027014214 heme pocket [chemical binding]; other site 1173027014215 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014217 putative active site [active] 1173027014218 heme pocket [chemical binding]; other site 1173027014219 PAS domain; Region: PAS_8; pfam13188 1173027014220 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014222 putative active site [active] 1173027014223 heme pocket [chemical binding]; other site 1173027014224 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027014225 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027014226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027014227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014228 ATP binding site [chemical binding]; other site 1173027014229 Mg2+ binding site [ion binding]; other site 1173027014230 G-X-G motif; other site 1173027014231 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1173027014232 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173027014233 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173027014234 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1173027014235 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173027014236 catalytic triad [active] 1173027014237 dimer interface [polypeptide binding]; other site 1173027014238 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173027014239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027014240 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1173027014241 putative metal binding site [ion binding]; other site 1173027014242 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173027014243 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 1173027014244 adenylate kinase; Reviewed; Region: adk; PRK00279 1173027014245 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1173027014246 AMP-binding site [chemical binding]; other site 1173027014247 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1173027014248 ribonuclease PH; Reviewed; Region: rph; PRK00173 1173027014249 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1173027014250 hexamer interface [polypeptide binding]; other site 1173027014251 active site 1173027014252 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1173027014253 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173027014254 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 1173027014255 Integral membrane protein DUF92; Region: DUF92; pfam01940 1173027014256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173027014257 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173027014258 active site 1173027014259 metal binding site [ion binding]; metal-binding site 1173027014260 Lipase (class 2); Region: Lipase_2; pfam01674 1173027014261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027014262 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027014263 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173027014264 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1173027014265 active site 1173027014266 dimer interfaces [polypeptide binding]; other site 1173027014267 catalytic residues [active] 1173027014268 putative lipid kinase; Reviewed; Region: PRK00861 1173027014269 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173027014270 PEGA domain; Region: PEGA; pfam08308 1173027014271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027014272 non-specific DNA binding site [nucleotide binding]; other site 1173027014273 salt bridge; other site 1173027014274 sequence-specific DNA binding site [nucleotide binding]; other site 1173027014275 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1173027014276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027014277 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173027014278 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027014279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027014280 catalytic loop [active] 1173027014281 iron binding site [ion binding]; other site 1173027014282 cobyric acid synthase; Provisional; Region: PRK00784 1173027014283 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1173027014284 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173027014285 catalytic triad [active] 1173027014286 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173027014287 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027014288 catalytic triad [active] 1173027014289 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173027014290 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173027014291 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027014292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027014293 Walker A/P-loop; other site 1173027014294 ATP binding site [chemical binding]; other site 1173027014295 Q-loop/lid; other site 1173027014296 ABC transporter signature motif; other site 1173027014297 Walker B; other site 1173027014298 D-loop; other site 1173027014299 H-loop/switch region; other site 1173027014300 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1173027014301 catalytic motif [active] 1173027014302 Zn binding site [ion binding]; other site 1173027014303 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1173027014304 trimer interface [polypeptide binding]; other site 1173027014305 active site 1173027014306 Thymidylate synthase complementing protein; Region: Thy1; cl03630 1173027014307 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027014308 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027014309 Predicted membrane protein [Function unknown]; Region: COG1808 1173027014310 Predicted membrane protein [Function unknown]; Region: COG4325 1173027014311 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1173027014312 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027014313 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027014314 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027014315 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027014316 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173027014317 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1173027014318 Colicin V production protein; Region: Colicin_V; cl00567 1173027014319 Penicillinase repressor; Region: Pencillinase_R; cl17580 1173027014320 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173027014321 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173027014322 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173027014323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173027014324 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1173027014325 substrate binding site [chemical binding]; other site 1173027014326 ATP binding site [chemical binding]; other site 1173027014327 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027014328 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027014329 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1173027014330 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173027014331 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173027014332 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 1173027014333 trehalose synthase; Region: treS_nterm; TIGR02456 1173027014334 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1173027014335 active site 1173027014336 catalytic site [active] 1173027014337 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1173027014338 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1173027014339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014340 TPR motif; other site 1173027014341 TPR repeat; Region: TPR_11; pfam13414 1173027014342 binding surface 1173027014343 TPR repeat; Region: TPR_11; pfam13414 1173027014344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014345 binding surface 1173027014346 TPR motif; other site 1173027014347 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173027014348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014349 binding surface 1173027014350 TPR motif; other site 1173027014351 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027014352 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1173027014353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027014354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173027014355 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1173027014356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027014357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027014358 homodimer interface [polypeptide binding]; other site 1173027014359 catalytic residue [active] 1173027014360 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1173027014361 IHF dimer interface [polypeptide binding]; other site 1173027014362 IHF - DNA interface [nucleotide binding]; other site 1173027014363 AMIN domain; Region: AMIN; pfam11741 1173027014364 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 1173027014365 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1173027014366 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1173027014367 Tumour-suppressor protein CtIP N-terminal domain; Region: CtIP_N; pfam10482 1173027014368 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1173027014369 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1173027014370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173027014371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173027014372 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1173027014373 putative hydrolase; Provisional; Region: PRK11460 1173027014374 S-layer homology domain; Region: SLH; pfam00395 1173027014375 S-layer homology domain; Region: SLH; pfam00395 1173027014376 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173027014377 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173027014378 S-layer homology domain; Region: SLH; pfam00395 1173027014379 S-layer homology domain; Region: SLH; pfam00395 1173027014380 S-layer homology domain; Region: SLH; pfam00395 1173027014381 S-layer homology domain; Region: SLH; pfam00395 1173027014382 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027014383 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027014384 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173027014385 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173027014386 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173027014387 agmatinase; Region: agmatinase; TIGR01230 1173027014388 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1173027014389 putative active site [active] 1173027014390 Mn binding site [ion binding]; other site 1173027014391 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173027014392 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027014393 putative catalytic residue [active] 1173027014394 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1173027014395 putative nucleotide binding site [chemical binding]; other site 1173027014396 uridine monophosphate binding site [chemical binding]; other site 1173027014397 homohexameric interface [polypeptide binding]; other site 1173027014398 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1173027014399 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1173027014400 hinge region; other site 1173027014401 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1173027014402 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1173027014403 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1173027014404 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173027014405 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1173027014406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027014407 motif II; other site 1173027014408 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 1173027014409 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1173027014410 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173027014411 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1173027014412 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1173027014413 PRC-barrel domain; Region: PRC; pfam05239 1173027014414 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1173027014415 Dihaem cytochrome c; Region: DHC; pfam09626 1173027014416 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173027014417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027014418 ATP binding site [chemical binding]; other site 1173027014419 Walker A motif; other site 1173027014420 Walker B motif; other site 1173027014421 arginine finger; other site 1173027014422 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1173027014423 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1173027014424 active site 1173027014425 Riboflavin kinase; Region: Flavokinase; smart00904 1173027014426 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173027014427 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173027014428 GSH binding site [chemical binding]; other site 1173027014429 catalytic residues [active] 1173027014430 glutathione synthetase; Provisional; Region: PRK05246 1173027014431 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1173027014432 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1173027014433 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1173027014434 AAA ATPase domain; Region: AAA_16; pfam13191 1173027014435 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 1173027014436 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173027014437 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1173027014438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027014439 Walker A motif; other site 1173027014440 ATP binding site [chemical binding]; other site 1173027014441 Walker B motif; other site 1173027014442 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1173027014443 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1173027014444 active site 1173027014445 Zn binding site [ion binding]; other site 1173027014446 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1173027014447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173027014448 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1173027014449 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1173027014450 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1173027014451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027014452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027014453 DNA binding residues [nucleotide binding] 1173027014454 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1173027014455 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1173027014456 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027014457 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027014458 cofactor binding site; other site 1173027014459 DNA binding site [nucleotide binding] 1173027014460 substrate interaction site [chemical binding]; other site 1173027014461 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173027014462 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027014463 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027014464 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027014465 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1173027014466 putative acyl-acceptor binding pocket; other site 1173027014467 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173027014468 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1173027014469 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1173027014470 substrate binding site [chemical binding]; other site 1173027014471 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1173027014472 substrate binding site [chemical binding]; other site 1173027014473 ligand binding site [chemical binding]; other site 1173027014474 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173027014475 Cytochrome c; Region: Cytochrom_C; pfam00034 1173027014476 Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529 1173027014477 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1173027014478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027014479 S-adenosylmethionine binding site [chemical binding]; other site 1173027014480 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1173027014481 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1173027014482 putative active site [active] 1173027014483 oxyanion strand; other site 1173027014484 catalytic triad [active] 1173027014485 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1173027014486 putative substrate binding pocket [chemical binding]; other site 1173027014487 AC domain interface; other site 1173027014488 catalytic triad [active] 1173027014489 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027014490 HEAT repeats; Region: HEAT_2; pfam13646 1173027014491 HEAT repeats; Region: HEAT_2; pfam13646 1173027014492 HEAT repeats; Region: HEAT_2; pfam13646 1173027014493 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027014494 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014495 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014496 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014497 CpeS-like protein; Region: CpeS; pfam09367 1173027014498 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 1173027014499 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 1173027014500 HEAT repeats; Region: HEAT_2; pfam13646 1173027014501 HEAT repeats; Region: HEAT_2; pfam13646 1173027014502 HEAT repeats; Region: HEAT_2; pfam13646 1173027014503 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027014504 HEAT repeats; Region: HEAT_2; pfam13646 1173027014505 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1173027014506 protein binding surface [polypeptide binding]; other site 1173027014507 HEAT repeats; Region: HEAT_2; pfam13646 1173027014508 HEAT repeats; Region: HEAT_2; pfam13646 1173027014509 HEAT repeats; Region: HEAT_2; pfam13646 1173027014510 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027014511 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027014512 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173027014513 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027014514 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027014515 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027014516 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027014517 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173027014518 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1173027014519 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1173027014520 CpeS-like protein; Region: CpeS; pfam09367 1173027014521 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173027014522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027014523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014524 active site 1173027014525 phosphorylation site [posttranslational modification] 1173027014526 intermolecular recognition site; other site 1173027014527 dimerization interface [polypeptide binding]; other site 1173027014528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027014529 DNA binding site [nucleotide binding] 1173027014530 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1173027014531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027014532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027014533 homodimer interface [polypeptide binding]; other site 1173027014534 catalytic residue [active] 1173027014535 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173027014536 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1173027014537 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1173027014538 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1173027014539 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 1173027014540 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173027014541 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027014542 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173027014543 Cache domain; Region: Cache_1; pfam02743 1173027014544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027014545 dimerization interface [polypeptide binding]; other site 1173027014546 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014548 putative active site [active] 1173027014549 heme pocket [chemical binding]; other site 1173027014550 GAF domain; Region: GAF; pfam01590 1173027014551 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027014552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014553 dimer interface [polypeptide binding]; other site 1173027014554 phosphorylation site [posttranslational modification] 1173027014555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027014556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014557 ATP binding site [chemical binding]; other site 1173027014558 Mg2+ binding site [ion binding]; other site 1173027014559 G-X-G motif; other site 1173027014560 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027014561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014562 active site 1173027014563 phosphorylation site [posttranslational modification] 1173027014564 intermolecular recognition site; other site 1173027014565 dimerization interface [polypeptide binding]; other site 1173027014566 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027014567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014568 active site 1173027014569 phosphorylation site [posttranslational modification] 1173027014570 intermolecular recognition site; other site 1173027014571 dimerization interface [polypeptide binding]; other site 1173027014572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014573 dimer interface [polypeptide binding]; other site 1173027014574 phosphorylation site [posttranslational modification] 1173027014575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014576 ATP binding site [chemical binding]; other site 1173027014577 Mg2+ binding site [ion binding]; other site 1173027014578 G-X-G motif; other site 1173027014579 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027014580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014581 active site 1173027014582 phosphorylation site [posttranslational modification] 1173027014583 intermolecular recognition site; other site 1173027014584 dimerization interface [polypeptide binding]; other site 1173027014585 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027014586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014587 active site 1173027014588 phosphorylation site [posttranslational modification] 1173027014589 intermolecular recognition site; other site 1173027014590 dimerization interface [polypeptide binding]; other site 1173027014591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027014592 GAF domain; Region: GAF; cl17456 1173027014593 PAS fold; Region: PAS_3; pfam08447 1173027014594 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173027014595 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1173027014596 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173027014597 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173027014598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027014599 dimer interface [polypeptide binding]; other site 1173027014600 conserved gate region; other site 1173027014601 putative PBP binding loops; other site 1173027014602 ABC-ATPase subunit interface; other site 1173027014603 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1173027014604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027014605 dimer interface [polypeptide binding]; other site 1173027014606 conserved gate region; other site 1173027014607 putative PBP binding loops; other site 1173027014608 ABC-ATPase subunit interface; other site 1173027014609 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173027014610 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173027014611 protein I interface; other site 1173027014612 D2 interface; other site 1173027014613 protein T interface; other site 1173027014614 chlorophyll binding site; other site 1173027014615 beta carotene binding site; other site 1173027014616 pheophytin binding site; other site 1173027014617 manganese-stabilizing polypeptide interface; other site 1173027014618 CP43 interface; other site 1173027014619 protein L interface; other site 1173027014620 oxygen evolving complex binding site; other site 1173027014621 bromide binding site; other site 1173027014622 quinone binding site; other site 1173027014623 Fe binding site [ion binding]; other site 1173027014624 core light harvesting interface; other site 1173027014625 cytochrome b559 alpha subunit interface; other site 1173027014626 cytochrome c-550 interface; other site 1173027014627 protein J interface; other site 1173027014628 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1173027014629 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1173027014630 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173027014631 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173027014632 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027014633 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014635 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014636 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027014637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014638 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014639 S-layer homology domain; Region: SLH; pfam00395 1173027014640 S-layer homology domain; Region: SLH; pfam00395 1173027014641 S-layer homology domain; Region: SLH; pfam00395 1173027014642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173027014643 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027014644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027014645 Probable transposase; Region: OrfB_IS605; pfam01385 1173027014646 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173027014647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027014648 putative PBP binding loops; other site 1173027014649 ABC-ATPase subunit interface; other site 1173027014650 PAS domain; Region: PAS_9; pfam13426 1173027014651 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014653 putative active site [active] 1173027014654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014655 PAS fold; Region: PAS_3; pfam08447 1173027014656 putative active site [active] 1173027014657 heme pocket [chemical binding]; other site 1173027014658 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027014659 GAF domain; Region: GAF_2; pfam13185 1173027014660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014661 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027014662 putative active site [active] 1173027014663 heme pocket [chemical binding]; other site 1173027014664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014665 putative active site [active] 1173027014666 heme pocket [chemical binding]; other site 1173027014667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027014668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027014669 metal binding site [ion binding]; metal-binding site 1173027014670 active site 1173027014671 I-site; other site 1173027014672 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173027014673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014674 TPR motif; other site 1173027014675 TPR repeat; Region: TPR_11; pfam13414 1173027014676 binding surface 1173027014677 CHAT domain; Region: CHAT; cl17868 1173027014678 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027014679 NAD synthetase; Provisional; Region: PRK13981 1173027014680 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1173027014681 multimer interface [polypeptide binding]; other site 1173027014682 active site 1173027014683 catalytic triad [active] 1173027014684 protein interface 1 [polypeptide binding]; other site 1173027014685 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1173027014686 homodimer interface [polypeptide binding]; other site 1173027014687 NAD binding pocket [chemical binding]; other site 1173027014688 ATP binding pocket [chemical binding]; other site 1173027014689 Mg binding site [ion binding]; other site 1173027014690 active-site loop [active] 1173027014691 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1173027014692 Beta-lactamase; Region: Beta-lactamase; pfam00144 1173027014693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027014694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027014695 putative substrate translocation pore; other site 1173027014696 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027014697 methionine aminopeptidase; Provisional; Region: PRK12318 1173027014698 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173027014699 active site 1173027014700 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1173027014701 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1173027014702 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1173027014703 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1173027014704 metal binding site [ion binding]; metal-binding site 1173027014705 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1173027014706 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173027014707 inhibitor-cofactor binding pocket; inhibition site 1173027014708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027014709 catalytic residue [active] 1173027014710 Domain of unknown function (DUF202); Region: DUF202; cl09954 1173027014711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1173027014712 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1173027014713 Predicted membrane protein [Function unknown]; Region: COG3686 1173027014714 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1173027014715 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027014716 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1173027014717 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173027014718 DNA binding residues [nucleotide binding] 1173027014719 putative dimer interface [polypeptide binding]; other site 1173027014720 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027014721 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1173027014722 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1173027014723 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173027014724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027014725 S-adenosylmethionine binding site [chemical binding]; other site 1173027014726 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027014727 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1173027014728 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027014729 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1173027014730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027014731 Walker A/P-loop; other site 1173027014732 ATP binding site [chemical binding]; other site 1173027014733 Q-loop/lid; other site 1173027014734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027014735 ABC transporter signature motif; other site 1173027014736 Walker B; other site 1173027014737 D-loop; other site 1173027014738 H-loop/switch region; other site 1173027014739 TIGR02646 family protein; Region: TIGR02646 1173027014740 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1173027014741 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1173027014742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027014743 ATP binding site [chemical binding]; other site 1173027014744 putative Mg++ binding site [ion binding]; other site 1173027014745 TniQ; Region: TniQ; pfam06527 1173027014746 Bacterial TniB protein; Region: TniB; pfam05621 1173027014747 AAA domain; Region: AAA_22; pfam13401 1173027014748 Helix-turn-helix domain; Region: HTH_28; pfam13518 1173027014749 Winged helix-turn helix; Region: HTH_29; pfam13551 1173027014750 Homeodomain-like domain; Region: HTH_32; pfam13565 1173027014751 Integrase core domain; Region: rve; pfam00665 1173027014752 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027014753 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173027014754 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173027014755 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1173027014756 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173027014757 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1173027014758 DNA-binding site [nucleotide binding]; DNA binding site 1173027014759 RNA-binding motif; other site 1173027014760 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1173027014761 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1173027014762 NAD binding site [chemical binding]; other site 1173027014763 homotetramer interface [polypeptide binding]; other site 1173027014764 homodimer interface [polypeptide binding]; other site 1173027014765 substrate binding site [chemical binding]; other site 1173027014766 active site 1173027014767 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027014768 NMT1-like family; Region: NMT1_2; pfam13379 1173027014769 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173027014770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027014771 dimer interface [polypeptide binding]; other site 1173027014772 conserved gate region; other site 1173027014773 ABC-ATPase subunit interface; other site 1173027014774 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027014775 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173027014776 Walker A/P-loop; other site 1173027014777 ATP binding site [chemical binding]; other site 1173027014778 Q-loop/lid; other site 1173027014779 ABC transporter signature motif; other site 1173027014780 Walker B; other site 1173027014781 D-loop; other site 1173027014782 H-loop/switch region; other site 1173027014783 NMT1-like family; Region: NMT1_2; pfam13379 1173027014784 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173027014785 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173027014786 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173027014787 Walker A/P-loop; other site 1173027014788 ATP binding site [chemical binding]; other site 1173027014789 Q-loop/lid; other site 1173027014790 ABC transporter signature motif; other site 1173027014791 Walker B; other site 1173027014792 D-loop; other site 1173027014793 H-loop/switch region; other site 1173027014794 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1173027014795 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027014796 tetramer interface [polypeptide binding]; other site 1173027014797 dimer interface [polypeptide binding]; other site 1173027014798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014799 PAS domain; Region: PAS_9; pfam13426 1173027014800 putative active site [active] 1173027014801 heme pocket [chemical binding]; other site 1173027014802 PAS fold; Region: PAS_4; pfam08448 1173027014803 PAS domain S-box; Region: sensory_box; TIGR00229 1173027014804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014805 putative active site [active] 1173027014806 heme pocket [chemical binding]; other site 1173027014807 PAS fold; Region: PAS_4; pfam08448 1173027014808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014809 putative active site [active] 1173027014810 heme pocket [chemical binding]; other site 1173027014811 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014812 PAS domain; Region: PAS_9; pfam13426 1173027014813 putative active site [active] 1173027014814 heme pocket [chemical binding]; other site 1173027014815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173027014816 Histidine kinase; Region: HisKA_2; pfam07568 1173027014817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014818 ATP binding site [chemical binding]; other site 1173027014819 Mg2+ binding site [ion binding]; other site 1173027014820 G-X-G motif; other site 1173027014821 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027014822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014823 active site 1173027014824 phosphorylation site [posttranslational modification] 1173027014825 intermolecular recognition site; other site 1173027014826 dimerization interface [polypeptide binding]; other site 1173027014827 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027014828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014829 putative active site [active] 1173027014830 heme pocket [chemical binding]; other site 1173027014831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014832 dimer interface [polypeptide binding]; other site 1173027014833 phosphorylation site [posttranslational modification] 1173027014834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014835 ATP binding site [chemical binding]; other site 1173027014836 Mg2+ binding site [ion binding]; other site 1173027014837 G-X-G motif; other site 1173027014838 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027014839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014840 active site 1173027014841 phosphorylation site [posttranslational modification] 1173027014842 intermolecular recognition site; other site 1173027014843 dimerization interface [polypeptide binding]; other site 1173027014844 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027014845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027014846 putative active site [active] 1173027014847 heme pocket [chemical binding]; other site 1173027014848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014849 dimer interface [polypeptide binding]; other site 1173027014850 phosphorylation site [posttranslational modification] 1173027014851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014852 ATP binding site [chemical binding]; other site 1173027014853 Mg2+ binding site [ion binding]; other site 1173027014854 G-X-G motif; other site 1173027014855 MASE1; Region: MASE1; cl17823 1173027014856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027014857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014858 dimer interface [polypeptide binding]; other site 1173027014859 phosphorylation site [posttranslational modification] 1173027014860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027014861 ATP binding site [chemical binding]; other site 1173027014862 Mg2+ binding site [ion binding]; other site 1173027014863 G-X-G motif; other site 1173027014864 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1173027014865 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1173027014866 putative substrate binding site [chemical binding]; other site 1173027014867 putative ATP binding site [chemical binding]; other site 1173027014868 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173027014869 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 1173027014870 catalytic triad [active] 1173027014871 putative active site [active] 1173027014872 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 1173027014873 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1173027014874 active site 1173027014875 Zn binding site [ion binding]; other site 1173027014876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027014877 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173027014878 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173027014879 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027014880 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1173027014881 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1173027014882 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1173027014883 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1173027014884 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1173027014885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173027014886 RNA binding surface [nucleotide binding]; other site 1173027014887 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1173027014888 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1173027014889 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1173027014890 dimerization interface [polypeptide binding]; other site 1173027014891 domain crossover interface; other site 1173027014892 redox-dependent activation switch; other site 1173027014893 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027014894 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173027014895 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173027014896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014897 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027014898 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014899 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027014900 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014901 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014902 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014903 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014904 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027014905 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027014906 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027014907 phosphopeptide binding site; other site 1173027014908 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 1173027014909 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1173027014910 OstA-like protein; Region: OstA; cl00844 1173027014911 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1173027014912 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1173027014913 Walker A/P-loop; other site 1173027014914 ATP binding site [chemical binding]; other site 1173027014915 Q-loop/lid; other site 1173027014916 ABC transporter signature motif; other site 1173027014917 Walker B; other site 1173027014918 D-loop; other site 1173027014919 H-loop/switch region; other site 1173027014920 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173027014921 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027014922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173027014923 Predicted permeases [General function prediction only]; Region: COG0795 1173027014924 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1173027014925 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1173027014926 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1173027014927 isocitrate dehydrogenase; Validated; Region: PRK07362 1173027014928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027014929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014930 active site 1173027014931 phosphorylation site [posttranslational modification] 1173027014932 intermolecular recognition site; other site 1173027014933 dimerization interface [polypeptide binding]; other site 1173027014934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027014935 DNA binding residues [nucleotide binding] 1173027014936 dimerization interface [polypeptide binding]; other site 1173027014937 GUN4-like; Region: GUN4; pfam05419 1173027014938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027014939 GAF domain; Region: GAF; pfam01590 1173027014940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027014941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027014942 dimer interface [polypeptide binding]; other site 1173027014943 phosphorylation site [posttranslational modification] 1173027014944 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 1173027014945 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173027014946 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1173027014947 SmpB-tmRNA interface; other site 1173027014948 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173027014949 Protein kinase domain; Region: Pkinase; pfam00069 1173027014950 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027014951 active site 1173027014952 ATP binding site [chemical binding]; other site 1173027014953 substrate binding site [chemical binding]; other site 1173027014954 activation loop (A-loop); other site 1173027014955 TPR repeat; Region: TPR_11; pfam13414 1173027014956 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173027014957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014958 binding surface 1173027014959 TPR motif; other site 1173027014960 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027014961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014962 binding surface 1173027014963 TPR motif; other site 1173027014964 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173027014965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027014966 binding surface 1173027014967 TPR motif; other site 1173027014968 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027014969 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 1173027014970 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1173027014971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027014972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027014973 active site 1173027014974 phosphorylation site [posttranslational modification] 1173027014975 intermolecular recognition site; other site 1173027014976 dimerization interface [polypeptide binding]; other site 1173027014977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027014978 DNA binding site [nucleotide binding] 1173027014979 geranylgeranyl reductase; Region: ChlP; TIGR02028 1173027014980 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173027014981 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173027014982 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1173027014983 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1173027014984 Walker A/P-loop; other site 1173027014985 ATP binding site [chemical binding]; other site 1173027014986 Q-loop/lid; other site 1173027014987 ABC transporter signature motif; other site 1173027014988 Walker B; other site 1173027014989 D-loop; other site 1173027014990 H-loop/switch region; other site 1173027014991 TOBE-like domain; Region: TOBE_3; pfam12857 1173027014992 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 1173027014993 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1173027014994 Stage II sporulation protein; Region: SpoIID; pfam08486 1173027014995 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1173027014996 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1173027014997 active site 1173027014998 substrate binding site [chemical binding]; other site 1173027014999 FMN binding site [chemical binding]; other site 1173027015000 putative catalytic residues [active] 1173027015001 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1173027015002 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173027015003 putative ligand binding site [chemical binding]; other site 1173027015004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015005 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027015006 putative active site [active] 1173027015007 heme pocket [chemical binding]; other site 1173027015008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015009 putative active site [active] 1173027015010 heme pocket [chemical binding]; other site 1173027015011 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027015012 cyclase homology domain; Region: CHD; cd07302 1173027015013 nucleotidyl binding site; other site 1173027015014 metal binding site [ion binding]; metal-binding site 1173027015015 dimer interface [polypeptide binding]; other site 1173027015016 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1173027015017 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1173027015018 domain interfaces; other site 1173027015019 active site 1173027015020 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173027015021 heme binding pocket [chemical binding]; other site 1173027015022 heme ligand [chemical binding]; other site 1173027015023 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015024 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027015026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027015027 DNA binding residues [nucleotide binding] 1173027015028 dimerization interface [polypeptide binding]; other site 1173027015029 glycogen synthase; Provisional; Region: glgA; PRK00654 1173027015030 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173027015031 ADP-binding pocket [chemical binding]; other site 1173027015032 homodimer interface [polypeptide binding]; other site 1173027015033 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027015034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015035 putative active site [active] 1173027015036 heme pocket [chemical binding]; other site 1173027015037 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027015038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015039 putative active site [active] 1173027015040 heme pocket [chemical binding]; other site 1173027015041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015042 putative active site [active] 1173027015043 heme pocket [chemical binding]; other site 1173027015044 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015045 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027015047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015048 dimer interface [polypeptide binding]; other site 1173027015049 phosphorylation site [posttranslational modification] 1173027015050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015051 ATP binding site [chemical binding]; other site 1173027015052 Mg2+ binding site [ion binding]; other site 1173027015053 G-X-G motif; other site 1173027015054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027015055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015056 active site 1173027015057 phosphorylation site [posttranslational modification] 1173027015058 intermolecular recognition site; other site 1173027015059 dimerization interface [polypeptide binding]; other site 1173027015060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027015061 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173027015062 putative substrate translocation pore; other site 1173027015063 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015064 putative active site [active] 1173027015065 LabA_like proteins; Region: LabA_like; cd06167 1173027015066 putative metal binding site [ion binding]; other site 1173027015067 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015068 putative active site [active] 1173027015069 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1173027015070 homoserine dehydrogenase; Provisional; Region: PRK06349 1173027015071 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1173027015072 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1173027015073 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1173027015074 RNase_H superfamily; Region: RNase_H_2; pfam13482 1173027015075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027015076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027015077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173027015078 active site 1173027015079 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173027015080 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027015081 active site 1173027015082 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1173027015083 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550 1173027015084 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015085 putative active site [active] 1173027015086 5-oxoprolinase; Region: PLN02666 1173027015087 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1173027015088 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1173027015089 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1173027015090 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1173027015091 active site 1173027015092 catalytic site [active] 1173027015093 substrate binding site [chemical binding]; other site 1173027015094 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1173027015095 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1173027015096 active site 1173027015097 Na/Ca binding site [ion binding]; other site 1173027015098 catalytic site [active] 1173027015099 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027015100 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027015101 P-loop; other site 1173027015102 Magnesium ion binding site [ion binding]; other site 1173027015103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027015104 Magnesium ion binding site [ion binding]; other site 1173027015105 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027015106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173027015107 substrate binding pocket [chemical binding]; other site 1173027015108 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1173027015109 Ion channel; Region: Ion_trans_2; pfam07885 1173027015110 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173027015111 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1173027015112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1173027015113 threonine dehydratase; Reviewed; Region: PRK09224 1173027015114 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1173027015115 tetramer interface [polypeptide binding]; other site 1173027015116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027015117 catalytic residue [active] 1173027015118 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1173027015119 putative Ile/Val binding site [chemical binding]; other site 1173027015120 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1173027015121 putative Ile/Val binding site [chemical binding]; other site 1173027015122 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173027015123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027015124 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173027015125 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173027015126 Predicted membrane protein [Function unknown]; Region: COG3431 1173027015127 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173027015128 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027015129 Walker A motif; other site 1173027015130 ATP binding site [chemical binding]; other site 1173027015131 Walker B motif; other site 1173027015132 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015133 putative active site [active] 1173027015134 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173027015135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027015136 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173027015137 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027015138 tetramer interface [polypeptide binding]; other site 1173027015139 dimer interface [polypeptide binding]; other site 1173027015140 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1173027015141 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 1173027015142 ligand binding surface [chemical binding]; other site 1173027015143 Family description; Region: VCBS; pfam13517 1173027015144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027015145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027015146 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173027015147 Walker A/P-loop; other site 1173027015148 ATP binding site [chemical binding]; other site 1173027015149 Q-loop/lid; other site 1173027015150 ABC transporter signature motif; other site 1173027015151 Walker B; other site 1173027015152 D-loop; other site 1173027015153 H-loop/switch region; other site 1173027015154 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173027015155 Active Sites [active] 1173027015156 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1173027015157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015158 S-adenosylmethionine binding site [chemical binding]; other site 1173027015159 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173027015160 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173027015161 putative di-iron ligands [ion binding]; other site 1173027015162 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1173027015163 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1173027015164 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173027015165 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027015166 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173027015167 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1173027015168 Nuclease-related domain; Region: NERD; pfam08378 1173027015169 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1173027015170 Family description; Region: UvrD_C_2; pfam13538 1173027015171 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015172 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027015173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015174 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015175 BON domain; Region: BON; pfam04972 1173027015176 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173027015177 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173027015178 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1173027015179 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 1173027015180 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1173027015181 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1173027015182 homotetramer interface [polypeptide binding]; other site 1173027015183 ligand binding site [chemical binding]; other site 1173027015184 catalytic site [active] 1173027015185 NAD binding site [chemical binding]; other site 1173027015186 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027015187 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027015188 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1173027015189 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015190 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1173027015191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173027015192 inhibitor-cofactor binding pocket; inhibition site 1173027015193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027015194 catalytic residue [active] 1173027015195 TPR repeat; Region: TPR_11; pfam13414 1173027015196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015197 binding surface 1173027015198 TPR motif; other site 1173027015199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015200 binding surface 1173027015201 TPR motif; other site 1173027015202 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027015203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015204 binding surface 1173027015205 TPR motif; other site 1173027015206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015207 binding surface 1173027015208 TPR motif; other site 1173027015209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015210 binding surface 1173027015211 TPR motif; other site 1173027015212 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173027015213 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1173027015214 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173027015215 putative active site [active] 1173027015216 putative metal binding site [ion binding]; other site 1173027015217 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027015218 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1173027015219 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1173027015220 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1173027015221 G1 box; other site 1173027015222 GTP/Mg2+ binding site [chemical binding]; other site 1173027015223 Switch I region; other site 1173027015224 G2 box; other site 1173027015225 Switch II region; other site 1173027015226 G3 box; other site 1173027015227 G4 box; other site 1173027015228 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1173027015229 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173027015230 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1173027015231 putative ligand binding site [chemical binding]; other site 1173027015232 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015233 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027015235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015236 dimer interface [polypeptide binding]; other site 1173027015237 phosphorylation site [posttranslational modification] 1173027015238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015239 ATP binding site [chemical binding]; other site 1173027015240 Mg2+ binding site [ion binding]; other site 1173027015241 G-X-G motif; other site 1173027015242 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1173027015243 active site clefts [active] 1173027015244 zinc binding site [ion binding]; other site 1173027015245 dimer interface [polypeptide binding]; other site 1173027015246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027015247 dimer interface [polypeptide binding]; other site 1173027015248 phosphorylation site [posttranslational modification] 1173027015249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015250 ATP binding site [chemical binding]; other site 1173027015251 Mg2+ binding site [ion binding]; other site 1173027015252 G-X-G motif; other site 1173027015253 GAF domain; Region: GAF_2; pfam13185 1173027015254 GAF domain; Region: GAF_3; pfam13492 1173027015255 PAS domain; Region: PAS_9; pfam13426 1173027015256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015257 putative active site [active] 1173027015258 heme pocket [chemical binding]; other site 1173027015259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015260 PAS fold; Region: PAS_3; pfam08447 1173027015261 putative active site [active] 1173027015262 heme pocket [chemical binding]; other site 1173027015263 PAS domain S-box; Region: sensory_box; TIGR00229 1173027015264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015265 putative active site [active] 1173027015266 heme pocket [chemical binding]; other site 1173027015267 PAS fold; Region: PAS_4; pfam08448 1173027015268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015269 putative active site [active] 1173027015270 heme pocket [chemical binding]; other site 1173027015271 GAF domain; Region: GAF_2; pfam13185 1173027015272 GAF domain; Region: GAF_3; pfam13492 1173027015273 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015274 GAF domain; Region: GAF; pfam01590 1173027015275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027015276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015277 dimer interface [polypeptide binding]; other site 1173027015278 phosphorylation site [posttranslational modification] 1173027015279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015280 ATP binding site [chemical binding]; other site 1173027015281 Mg2+ binding site [ion binding]; other site 1173027015282 G-X-G motif; other site 1173027015283 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1173027015284 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1173027015285 Walker A/P-loop; other site 1173027015286 ATP binding site [chemical binding]; other site 1173027015287 Q-loop/lid; other site 1173027015288 Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423 1173027015289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027015290 ABC transporter signature motif; other site 1173027015291 Walker B; other site 1173027015292 D-loop; other site 1173027015293 H-loop/switch region; other site 1173027015294 Caspase domain; Region: Peptidase_C14; pfam00656 1173027015295 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1173027015296 Amidinotransferase; Region: Amidinotransf; cl12043 1173027015297 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1173027015298 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1173027015299 homodimer interface [polypeptide binding]; other site 1173027015300 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027015301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015302 PAS domain; Region: PAS_9; pfam13426 1173027015303 putative active site [active] 1173027015304 heme pocket [chemical binding]; other site 1173027015305 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027015306 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1173027015307 ligand binding site [chemical binding]; other site 1173027015308 flexible hinge region; other site 1173027015309 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027015310 putative switch regulator; other site 1173027015311 non-specific DNA interactions [nucleotide binding]; other site 1173027015312 DNA binding site [nucleotide binding] 1173027015313 sequence specific DNA binding site [nucleotide binding]; other site 1173027015314 putative cAMP binding site [chemical binding]; other site 1173027015315 S-layer homology domain; Region: SLH; pfam00395 1173027015316 S-layer homology domain; Region: SLH; pfam00395 1173027015317 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173027015318 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027015319 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027015320 active site 1173027015321 metal binding site [ion binding]; metal-binding site 1173027015322 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173027015323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173027015324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027015325 active site 1173027015326 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173027015327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027015328 active site 1173027015329 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027015330 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027015331 active site 1173027015332 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 1173027015333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027015334 active site 1173027015335 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1173027015336 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173027015337 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173027015338 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173027015339 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027015340 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027015341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027015342 Walker A motif; other site 1173027015343 ATP binding site [chemical binding]; other site 1173027015344 Walker B motif; other site 1173027015345 arginine finger; other site 1173027015346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027015347 Walker A motif; other site 1173027015348 ATP binding site [chemical binding]; other site 1173027015349 Walker B motif; other site 1173027015350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173027015351 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 1173027015352 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1173027015353 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1173027015354 active site 1173027015355 catalytic triad [active] 1173027015356 oxyanion hole [active] 1173027015357 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1173027015358 S-layer homology domain; Region: SLH; pfam00395 1173027015359 AIR carboxylase; Region: AIRC; pfam00731 1173027015360 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1173027015361 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1173027015362 active site 1173027015363 dimer interface [polypeptide binding]; other site 1173027015364 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1173027015365 putative substrate binding region [chemical binding]; other site 1173027015366 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1173027015367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015368 S-adenosylmethionine binding site [chemical binding]; other site 1173027015369 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1173027015370 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1173027015371 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015372 putative active site [active] 1173027015373 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1173027015374 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1173027015375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027015376 non-specific DNA binding site [nucleotide binding]; other site 1173027015377 salt bridge; other site 1173027015378 sequence-specific DNA binding site [nucleotide binding]; other site 1173027015379 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1173027015380 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1173027015381 putative dimer interface [polypeptide binding]; other site 1173027015382 putative anticodon binding site; other site 1173027015383 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1173027015384 homodimer interface [polypeptide binding]; other site 1173027015385 motif 1; other site 1173027015386 motif 2; other site 1173027015387 active site 1173027015388 motif 3; other site 1173027015389 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027015390 nudix motif; other site 1173027015391 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 1173027015392 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173027015393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173027015394 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1173027015395 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1173027015396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015397 S-adenosylmethionine binding site [chemical binding]; other site 1173027015398 Phycobilisome protein; Region: Phycobilisome; cl08227 1173027015399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027015400 TPR motif; other site 1173027015401 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1173027015402 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173027015403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027015404 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1173027015405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027015406 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173027015407 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027015408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015409 S-adenosylmethionine binding site [chemical binding]; other site 1173027015410 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173027015411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173027015412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027015413 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 1173027015414 catalytic residues [active] 1173027015415 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173027015416 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027015417 putative metal binding site; other site 1173027015418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015419 TPR motif; other site 1173027015420 binding surface 1173027015421 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173027015422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027015423 dimer interface [polypeptide binding]; other site 1173027015424 conserved gate region; other site 1173027015425 ABC-ATPase subunit interface; other site 1173027015426 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1173027015427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173027015428 nucleotide binding site [chemical binding]; other site 1173027015429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015430 PAS domain; Region: PAS_9; pfam13426 1173027015431 putative active site [active] 1173027015432 heme pocket [chemical binding]; other site 1173027015433 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027015434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015435 putative active site [active] 1173027015436 heme pocket [chemical binding]; other site 1173027015437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015438 dimer interface [polypeptide binding]; other site 1173027015439 phosphorylation site [posttranslational modification] 1173027015440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015441 ATP binding site [chemical binding]; other site 1173027015442 Mg2+ binding site [ion binding]; other site 1173027015443 G-X-G motif; other site 1173027015444 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027015445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015446 active site 1173027015447 phosphorylation site [posttranslational modification] 1173027015448 intermolecular recognition site; other site 1173027015449 dimerization interface [polypeptide binding]; other site 1173027015450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015451 TPR motif; other site 1173027015452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015453 binding surface 1173027015454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015456 binding surface 1173027015457 TPR motif; other site 1173027015458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015460 binding surface 1173027015461 TPR motif; other site 1173027015462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015464 binding surface 1173027015465 TPR motif; other site 1173027015466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015467 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015469 binding surface 1173027015470 TPR motif; other site 1173027015471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015473 binding surface 1173027015474 TPR motif; other site 1173027015475 CHAT domain; Region: CHAT; pfam12770 1173027015476 CTP synthetase; Validated; Region: pyrG; PRK05380 1173027015477 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1173027015478 Catalytic site [active] 1173027015479 active site 1173027015480 UTP binding site [chemical binding]; other site 1173027015481 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1173027015482 active site 1173027015483 putative oxyanion hole; other site 1173027015484 catalytic triad [active] 1173027015485 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173027015486 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173027015487 Ligand Binding Site [chemical binding]; other site 1173027015488 Molecular Tunnel; other site 1173027015489 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173027015490 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173027015491 iron-sulfur cluster [ion binding]; other site 1173027015492 [2Fe-2S] cluster binding site [ion binding]; other site 1173027015493 heat shock protein 90; Provisional; Region: PRK05218 1173027015494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015495 ATP binding site [chemical binding]; other site 1173027015496 Mg2+ binding site [ion binding]; other site 1173027015497 G-X-G motif; other site 1173027015498 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1173027015499 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173027015500 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1173027015501 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1173027015502 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1173027015503 glycogen branching enzyme; Provisional; Region: PRK05402 1173027015504 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1173027015505 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1173027015506 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1173027015507 active site 1173027015508 catalytic site [active] 1173027015509 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173027015510 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015511 GAF domain; Region: GAF; pfam01590 1173027015512 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015513 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027015515 dimer interface [polypeptide binding]; other site 1173027015516 phosphorylation site [posttranslational modification] 1173027015517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015518 ATP binding site [chemical binding]; other site 1173027015519 G-X-G motif; other site 1173027015520 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1173027015521 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173027015522 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173027015523 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1173027015524 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1173027015525 catalytic residues [active] 1173027015526 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173027015527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027015528 Zn2+ binding site [ion binding]; other site 1173027015529 Mg2+ binding site [ion binding]; other site 1173027015530 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173027015531 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1173027015532 Moco binding site; other site 1173027015533 metal coordination site [ion binding]; other site 1173027015534 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1173027015535 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015536 GAF domain; Region: GAF; pfam01590 1173027015537 Phytochrome region; Region: PHY; pfam00360 1173027015538 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015540 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027015542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015543 dimer interface [polypeptide binding]; other site 1173027015544 phosphorylation site [posttranslational modification] 1173027015545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015546 ATP binding site [chemical binding]; other site 1173027015547 Mg2+ binding site [ion binding]; other site 1173027015548 G-X-G motif; other site 1173027015549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 1173027015550 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1173027015551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1173027015552 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173027015553 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027015554 putative binding surface; other site 1173027015555 active site 1173027015556 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027015557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015558 ATP binding site [chemical binding]; other site 1173027015559 Mg2+ binding site [ion binding]; other site 1173027015560 G-X-G motif; other site 1173027015561 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027015562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015563 active site 1173027015564 phosphorylation site [posttranslational modification] 1173027015565 intermolecular recognition site; other site 1173027015566 dimerization interface [polypeptide binding]; other site 1173027015567 Cache domain; Region: Cache_1; pfam02743 1173027015568 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027015569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027015570 dimerization interface [polypeptide binding]; other site 1173027015571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027015572 dimer interface [polypeptide binding]; other site 1173027015573 putative CheW interface [polypeptide binding]; other site 1173027015574 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1173027015575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027015576 dimerization interface [polypeptide binding]; other site 1173027015577 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015578 GAF domain; Region: GAF; pfam01590 1173027015579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027015580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027015581 dimer interface [polypeptide binding]; other site 1173027015582 putative CheW interface [polypeptide binding]; other site 1173027015583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015584 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027015585 active site 1173027015586 phosphorylation site [posttranslational modification] 1173027015587 intermolecular recognition site; other site 1173027015588 dimerization interface [polypeptide binding]; other site 1173027015589 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027015590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015591 active site 1173027015592 phosphorylation site [posttranslational modification] 1173027015593 intermolecular recognition site; other site 1173027015594 dimerization interface [polypeptide binding]; other site 1173027015595 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173027015596 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1173027015597 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1173027015598 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1173027015599 active site 1173027015600 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1173027015601 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1173027015602 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1173027015603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173027015604 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027015605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173027015606 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027015607 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015608 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015609 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015610 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015612 putative active site [active] 1173027015613 heme pocket [chemical binding]; other site 1173027015614 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027015615 cyclase homology domain; Region: CHD; cd07302 1173027015616 nucleotidyl binding site; other site 1173027015617 metal binding site [ion binding]; metal-binding site 1173027015618 dimer interface [polypeptide binding]; other site 1173027015619 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1173027015620 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1173027015621 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1173027015622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027015623 NAD binding site [chemical binding]; other site 1173027015624 substrate binding site [chemical binding]; other site 1173027015625 active site 1173027015626 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027015627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015628 binding surface 1173027015629 TPR motif; other site 1173027015630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015631 binding surface 1173027015632 TPR motif; other site 1173027015633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015634 binding surface 1173027015635 TPR motif; other site 1173027015636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027015637 CHAT domain; Region: CHAT; cl17868 1173027015638 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173027015639 mercuric reductase; Validated; Region: PRK06370 1173027015640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027015641 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173027015642 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173027015643 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173027015644 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1173027015645 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1173027015646 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1173027015647 dimer interface [polypeptide binding]; other site 1173027015648 substrate binding site [chemical binding]; other site 1173027015649 metal binding sites [ion binding]; metal-binding site 1173027015650 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1173027015651 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173027015652 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173027015653 active site residue [active] 1173027015654 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173027015655 active site residue [active] 1173027015656 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173027015657 LabA_like proteins; Region: LabA; cd10911 1173027015658 putative metal binding site [ion binding]; other site 1173027015659 2-isopropylmalate synthase; Validated; Region: PRK00915 1173027015660 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173027015661 active site 1173027015662 catalytic residues [active] 1173027015663 metal binding site [ion binding]; metal-binding site 1173027015664 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1173027015665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015666 S-adenosylmethionine binding site [chemical binding]; other site 1173027015667 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173027015668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027015669 ATP binding site [chemical binding]; other site 1173027015670 putative Mg++ binding site [ion binding]; other site 1173027015671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027015672 nucleotide binding region [chemical binding]; other site 1173027015673 ATP-binding site [chemical binding]; other site 1173027015674 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027015675 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027015676 active site 1173027015677 ATP binding site [chemical binding]; other site 1173027015678 substrate binding site [chemical binding]; other site 1173027015679 activation loop (A-loop); other site 1173027015680 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027015681 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015682 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015683 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015684 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173027015685 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173027015686 NAD(P) binding site [chemical binding]; other site 1173027015687 putative active site [active] 1173027015688 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173027015689 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173027015690 putative dimer interface [polypeptide binding]; other site 1173027015691 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173027015692 serine O-acetyltransferase; Region: cysE; TIGR01172 1173027015693 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173027015694 trimer interface [polypeptide binding]; other site 1173027015695 active site 1173027015696 substrate binding site [chemical binding]; other site 1173027015697 CoA binding site [chemical binding]; other site 1173027015698 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1173027015699 ribosomal protein S4(archaeal type)/S9(eukaryote cytosolic type); Region: rpsD_arch; TIGR01018 1173027015700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173027015701 RNA binding surface [nucleotide binding]; other site 1173027015702 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1173027015703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027015704 FeS/SAM binding site; other site 1173027015705 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1173027015706 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027015707 putative active site [active] 1173027015708 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173027015709 active site 1173027015710 HEAT repeats; Region: HEAT_2; pfam13646 1173027015711 HEAT repeats; Region: HEAT_2; pfam13646 1173027015712 HEAT repeats; Region: HEAT_2; pfam13646 1173027015713 NACHT domain; Region: NACHT; pfam05729 1173027015714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173027015715 Walker A motif; other site 1173027015716 ATP binding site [chemical binding]; other site 1173027015717 Walker B motif; other site 1173027015718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027015719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173027015720 putative substrate translocation pore; other site 1173027015721 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1173027015722 GMP synthase; Reviewed; Region: guaA; PRK00074 1173027015723 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1173027015724 AMP/PPi binding site [chemical binding]; other site 1173027015725 candidate oxyanion hole; other site 1173027015726 catalytic triad [active] 1173027015727 potential glutamine specificity residues [chemical binding]; other site 1173027015728 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1173027015729 ATP Binding subdomain [chemical binding]; other site 1173027015730 Ligand Binding sites [chemical binding]; other site 1173027015731 Dimerization subdomain; other site 1173027015732 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015733 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027015734 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015735 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015736 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027015737 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015738 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1173027015739 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1173027015740 Ligand Binding Site [chemical binding]; other site 1173027015741 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1173027015742 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1173027015743 ArsC family; Region: ArsC; pfam03960 1173027015744 catalytic residue [active] 1173027015745 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1173027015746 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1173027015747 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173027015748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027015749 catalytic triad [active] 1173027015750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173027015751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173027015752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173027015753 dimerization interface [polypeptide binding]; other site 1173027015754 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173027015755 EamA-like transporter family; Region: EamA; pfam00892 1173027015756 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027015757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015758 S-adenosylmethionine binding site [chemical binding]; other site 1173027015759 L-type amino acid transporter; Region: 2A0308; TIGR00911 1173027015760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173027015761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173027015762 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173027015763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027015764 ABC-ATPase subunit interface; other site 1173027015765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173027015766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027015767 dimer interface [polypeptide binding]; other site 1173027015768 conserved gate region; other site 1173027015769 putative PBP binding loops; other site 1173027015770 ABC-ATPase subunit interface; other site 1173027015771 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173027015772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015773 S-adenosylmethionine binding site [chemical binding]; other site 1173027015774 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027015775 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027015776 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027015777 PAS domain S-box; Region: sensory_box; TIGR00229 1173027015778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027015779 putative active site [active] 1173027015780 heme pocket [chemical binding]; other site 1173027015781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173027015782 Histidine kinase; Region: HisKA_2; pfam07568 1173027015783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015784 ATP binding site [chemical binding]; other site 1173027015785 Mg2+ binding site [ion binding]; other site 1173027015786 G-X-G motif; other site 1173027015787 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027015788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027015789 active site 1173027015790 phosphorylation site [posttranslational modification] 1173027015791 intermolecular recognition site; other site 1173027015792 dimerization interface [polypeptide binding]; other site 1173027015793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027015794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027015795 dimer interface [polypeptide binding]; other site 1173027015796 phosphorylation site [posttranslational modification] 1173027015797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027015798 ATP binding site [chemical binding]; other site 1173027015799 Mg2+ binding site [ion binding]; other site 1173027015800 G-X-G motif; other site 1173027015801 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 1173027015802 S-layer homology domain; Region: SLH; pfam00395 1173027015803 S-layer homology domain; Region: SLH; pfam00395 1173027015804 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027015805 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027015806 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027015807 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027015808 active site 1173027015809 metal binding site [ion binding]; metal-binding site 1173027015810 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027015811 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027015812 structural tetrad; other site 1173027015813 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027015814 structural tetrad; other site 1173027015815 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027015816 structural tetrad; other site 1173027015817 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027015818 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027015819 structural tetrad; other site 1173027015820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015821 TPR motif; other site 1173027015822 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027015823 binding surface 1173027015824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015825 binding surface 1173027015826 TPR motif; other site 1173027015827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015828 binding surface 1173027015829 TPR motif; other site 1173027015830 CHAT domain; Region: CHAT; pfam12770 1173027015831 DNA primase; Validated; Region: dnaG; PRK05667 1173027015832 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1173027015833 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173027015834 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1173027015835 active site 1173027015836 metal binding site [ion binding]; metal-binding site 1173027015837 interdomain interaction site; other site 1173027015838 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1173027015839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015840 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027015841 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015842 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015843 hypothetical protein; Reviewed; Region: PRK12497 1173027015844 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1173027015845 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1173027015846 TPR repeat; Region: TPR_11; pfam13414 1173027015847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015848 binding surface 1173027015849 TPR repeat; Region: TPR_11; pfam13414 1173027015850 TPR motif; other site 1173027015851 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027015852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015853 binding surface 1173027015854 TPR motif; other site 1173027015855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015856 binding surface 1173027015857 TPR motif; other site 1173027015858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027015859 binding surface 1173027015860 TPR motif; other site 1173027015861 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027015862 TrkA-N domain; Region: TrkA_N; pfam02254 1173027015863 TrkA-C domain; Region: TrkA_C; pfam02080 1173027015864 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1173027015865 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1173027015866 tocopherol O-methyltransferase; Region: PLN02244 1173027015867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027015868 S-adenosylmethionine binding site [chemical binding]; other site 1173027015869 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 1173027015870 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1173027015871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173027015872 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1173027015873 hypothetical protein; Provisional; Region: PRK07377 1173027015874 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 1173027015875 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1173027015876 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1173027015877 dimer interface [polypeptide binding]; other site 1173027015878 FMN binding site [chemical binding]; other site 1173027015879 Predicted transcriptional regulators [Transcription]; Region: COG1725 1173027015880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173027015881 DNA-binding site [nucleotide binding]; DNA binding site 1173027015882 Dienelactone hydrolase family; Region: DLH; pfam01738 1173027015883 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1173027015884 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173027015885 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173027015886 RNA binding site [nucleotide binding]; other site 1173027015887 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173027015888 RNA binding site [nucleotide binding]; other site 1173027015889 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1173027015890 RNA binding site [nucleotide binding]; other site 1173027015891 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1173027015892 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173027015893 nucleotide binding site [chemical binding]; other site 1173027015894 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1173027015895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027015896 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027015897 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027015898 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027015899 Phosphotransferase enzyme family; Region: APH; pfam01636 1173027015900 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173027015901 active site 1173027015902 ATP binding site [chemical binding]; other site 1173027015903 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173027015904 substrate binding site [chemical binding]; other site 1173027015905 Nuclease-related domain; Region: NERD; pfam08378 1173027015906 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1173027015907 Family description; Region: UvrD_C_2; pfam13538 1173027015908 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1173027015909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173027015910 active site residue [active] 1173027015911 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173027015912 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173027015913 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1173027015914 active site 1173027015915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027015916 non-specific DNA binding site [nucleotide binding]; other site 1173027015917 salt bridge; other site 1173027015918 sequence-specific DNA binding site [nucleotide binding]; other site 1173027015919 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027015920 active site 1173027015921 NTP binding site [chemical binding]; other site 1173027015922 metal binding triad [ion binding]; metal-binding site 1173027015923 antibiotic binding site [chemical binding]; other site 1173027015924 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173027015925 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1173027015926 beta-galactosidase; Region: BGL; TIGR03356 1173027015927 hypothetical protein; Provisional; Region: PRK09256 1173027015928 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1173027015929 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173027015930 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173027015931 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173027015932 Cupin domain; Region: Cupin_2; cl17218 1173027015933 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1173027015934 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1173027015935 NADP binding site [chemical binding]; other site 1173027015936 homodimer interface [polypeptide binding]; other site 1173027015937 active site 1173027015938 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1173027015939 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1173027015940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173027015941 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1173027015942 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173027015943 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027015944 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173027015945 catalytic site [active] 1173027015946 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1173027015947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015948 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027015949 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015950 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015953 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027015954 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 1173027015955 putative hexamer interface [polypeptide binding]; other site 1173027015956 putative hexagonal pore; other site 1173027015957 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173027015958 Hexamer interface [polypeptide binding]; other site 1173027015959 Hexagonal pore residue; other site 1173027015960 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1173027015961 ATP binding site [chemical binding]; other site 1173027015962 active site 1173027015963 substrate binding site [chemical binding]; other site 1173027015964 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1173027015965 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027015966 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1173027015967 catalytic triad [active] 1173027015968 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1173027015969 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027015970 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1173027015971 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1173027015972 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1173027015973 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1173027015974 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1173027015975 putative active site [active] 1173027015976 transaldolase; Provisional; Region: PRK03903 1173027015977 catalytic residue [active] 1173027015978 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1173027015979 AMP binding site [chemical binding]; other site 1173027015980 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1173027015981 metal binding site [ion binding]; metal-binding site 1173027015982 active site 1173027015983 6-phosphofructokinase; Provisional; Region: PRK14071 1173027015984 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173027015985 active site 1173027015986 ADP/pyrophosphate binding site [chemical binding]; other site 1173027015987 dimerization interface [polypeptide binding]; other site 1173027015988 allosteric effector site; other site 1173027015989 fructose-1,6-bisphosphate binding site; other site 1173027015990 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027015991 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173027015992 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1173027015993 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1173027015994 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173027015995 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1173027015996 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173027015997 trimer interface [polypeptide binding]; other site 1173027015998 active site 1173027015999 substrate binding site [chemical binding]; other site 1173027016000 CoA binding site [chemical binding]; other site 1173027016001 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1173027016002 RimM N-terminal domain; Region: RimM; pfam01782 1173027016003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173027016004 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173027016005 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1173027016006 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1173027016007 interface (dimer of trimers) [polypeptide binding]; other site 1173027016008 Substrate-binding/catalytic site; other site 1173027016009 Zn-binding sites [ion binding]; other site 1173027016010 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1173027016011 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1173027016012 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1173027016013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1173027016014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1173027016015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1173027016016 catalytic residue [active] 1173027016017 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1173027016018 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173027016019 ABC-ATPase subunit interface; other site 1173027016020 dimer interface [polypeptide binding]; other site 1173027016021 putative PBP binding regions; other site 1173027016022 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027016023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027016024 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173027016025 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173027016026 Walker A/P-loop; other site 1173027016027 ATP binding site [chemical binding]; other site 1173027016028 Q-loop/lid; other site 1173027016029 ABC transporter signature motif; other site 1173027016030 Walker B; other site 1173027016031 D-loop; other site 1173027016032 H-loop/switch region; other site 1173027016033 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173027016034 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173027016035 intersubunit interface [polypeptide binding]; other site 1173027016036 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 1173027016037 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027016038 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027016039 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 1173027016040 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 1173027016041 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 1173027016042 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1173027016043 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 1173027016044 cytochrome b subunit interaction site [polypeptide binding]; other site 1173027016045 [2Fe-2S] cluster binding site [ion binding]; other site 1173027016046 apocytochrome f; Reviewed; Region: PRK02693 1173027016047 cytochrome f; Region: petA; CHL00037 1173027016048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027016049 Probable transposase; Region: OrfB_IS605; pfam01385 1173027016050 Helix-turn-helix domain; Region: HTH_17; cl17695 1173027016051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027016052 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016053 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173027016054 putative ADP-binding pocket [chemical binding]; other site 1173027016055 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1173027016056 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173027016057 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1173027016058 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173027016059 DTAP/Switch II; other site 1173027016060 Switch I; other site 1173027016061 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 1173027016062 Probable transposase; Region: OrfB_IS605; pfam01385 1173027016063 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173027016064 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1173027016065 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173027016066 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1173027016067 Mg++ binding site [ion binding]; other site 1173027016068 putative catalytic motif [active] 1173027016069 putative substrate binding site [chemical binding]; other site 1173027016070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173027016071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027016072 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1173027016073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016074 putative ADP-binding pocket [chemical binding]; other site 1173027016075 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027016076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173027016077 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1173027016078 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1173027016079 active site 1173027016080 dimer interface [polypeptide binding]; other site 1173027016081 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173027016082 Ligand Binding Site [chemical binding]; other site 1173027016083 Molecular Tunnel; other site 1173027016084 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173027016085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016086 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027016087 S-adenosylmethionine binding site [chemical binding]; other site 1173027016088 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1173027016089 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1173027016090 putative ADP-binding pocket [chemical binding]; other site 1173027016091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016092 S-adenosylmethionine binding site [chemical binding]; other site 1173027016093 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027016094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016095 S-adenosylmethionine binding site [chemical binding]; other site 1173027016096 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027016097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016098 S-adenosylmethionine binding site [chemical binding]; other site 1173027016099 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173027016100 MviN-like protein; Region: MVIN; pfam03023 1173027016101 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1173027016102 CoA binding domain; Region: CoA_binding; cl17356 1173027016103 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1173027016104 NAD(P) binding site [chemical binding]; other site 1173027016105 homodimer interface [polypeptide binding]; other site 1173027016106 substrate binding site [chemical binding]; other site 1173027016107 active site 1173027016108 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173027016109 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173027016110 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173027016111 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173027016112 Walker A/P-loop; other site 1173027016113 ATP binding site [chemical binding]; other site 1173027016114 Q-loop/lid; other site 1173027016115 ABC transporter signature motif; other site 1173027016116 Walker B; other site 1173027016117 D-loop; other site 1173027016118 H-loop/switch region; other site 1173027016119 O-Antigen ligase; Region: Wzy_C; pfam04932 1173027016120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016121 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027016122 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027016123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016125 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027016126 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027016127 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1173027016128 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027016129 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173027016130 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1173027016131 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1173027016132 Ligand binding site; other site 1173027016133 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027016134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016135 S-adenosylmethionine binding site [chemical binding]; other site 1173027016136 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1173027016137 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173027016138 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027016139 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173027016140 Probable Catalytic site; other site 1173027016141 metal-binding site 1173027016142 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173027016143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016144 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173027016145 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173027016146 NADP-binding site; other site 1173027016147 homotetramer interface [polypeptide binding]; other site 1173027016148 substrate binding site [chemical binding]; other site 1173027016149 homodimer interface [polypeptide binding]; other site 1173027016150 active site 1173027016151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027016152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027016153 DNA binding site [nucleotide binding] 1173027016154 GTP-binding protein Der; Reviewed; Region: PRK00093 1173027016155 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1173027016156 G1 box; other site 1173027016157 GTP/Mg2+ binding site [chemical binding]; other site 1173027016158 Switch I region; other site 1173027016159 G2 box; other site 1173027016160 Switch II region; other site 1173027016161 G3 box; other site 1173027016162 G4 box; other site 1173027016163 G5 box; other site 1173027016164 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1173027016165 G1 box; other site 1173027016166 GTP/Mg2+ binding site [chemical binding]; other site 1173027016167 Switch I region; other site 1173027016168 G2 box; other site 1173027016169 G3 box; other site 1173027016170 Switch II region; other site 1173027016171 G4 box; other site 1173027016172 G5 box; other site 1173027016173 Cobalt transport protein; Region: CbiQ; cl00463 1173027016174 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1173027016175 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173027016176 Substrate binding site [chemical binding]; other site 1173027016177 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016178 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016179 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016180 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016181 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016182 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016183 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173027016184 Leucine rich repeat; Region: LRR_8; pfam13855 1173027016185 GUN4-like; Region: GUN4; pfam05419 1173027016186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016189 binding surface 1173027016190 TPR motif; other site 1173027016191 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016193 binding surface 1173027016194 TPR motif; other site 1173027016195 TPR repeat; Region: TPR_11; pfam13414 1173027016196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016197 binding surface 1173027016198 TPR motif; other site 1173027016199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016202 binding surface 1173027016203 TPR motif; other site 1173027016204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027016205 anthranilate synthase component I-like protein; Validated; Region: PRK05940 1173027016206 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173027016207 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173027016208 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1173027016209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027016210 Probable transposase; Region: OrfB_IS605; pfam01385 1173027016211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1173027016212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173027016213 catalytic residue [active] 1173027016214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1173027016215 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1173027016216 pyrroline-5-carboxylate reductase; Region: PLN02688 1173027016217 membrane protein; Provisional; Region: PRK14419 1173027016218 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 1173027016219 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 1173027016220 Permease; Region: Permease; cl00510 1173027016221 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173027016222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016223 binding surface 1173027016224 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027016225 TPR motif; other site 1173027016226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027016227 dimerization interface [polypeptide binding]; other site 1173027016228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027016229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027016230 dimer interface [polypeptide binding]; other site 1173027016231 putative CheW interface [polypeptide binding]; other site 1173027016232 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027016233 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027016234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016235 active site 1173027016236 phosphorylation site [posttranslational modification] 1173027016237 intermolecular recognition site; other site 1173027016238 dimerization interface [polypeptide binding]; other site 1173027016239 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027016240 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027016241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016242 active site 1173027016243 phosphorylation site [posttranslational modification] 1173027016244 intermolecular recognition site; other site 1173027016245 dimerization interface [polypeptide binding]; other site 1173027016246 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173027016247 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1173027016248 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1173027016249 Ligand Binding Site [chemical binding]; other site 1173027016250 KGK domain; Region: KGK; pfam08872 1173027016251 cytochrome c biogenesis protein; Region: ccsA; CHL00045 1173027016252 cytochrome c biogenesis protein; Region: ccsA; CHL00045 1173027016253 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173027016254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016255 binding surface 1173027016256 TPR motif; other site 1173027016257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016259 binding surface 1173027016260 TPR motif; other site 1173027016261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016264 Tetratricopeptide repeat; Region: TPR_10; cl17452 1173027016265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016266 CHAT domain; Region: CHAT; pfam12770 1173027016267 FO synthase subunit 2; Reviewed; Region: PRK07360 1173027016268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027016269 FeS/SAM binding site; other site 1173027016270 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173027016271 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173027016272 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1173027016273 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1173027016274 Ligand binding site; other site 1173027016275 Putative Catalytic site; other site 1173027016276 DXD motif; other site 1173027016277 Predicted membrane protein [Function unknown]; Region: COG2246 1173027016278 GtrA-like protein; Region: GtrA; pfam04138 1173027016279 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027016280 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173027016281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027016282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027016283 ligand binding site [chemical binding]; other site 1173027016284 flexible hinge region; other site 1173027016285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027016286 Coenzyme A binding pocket [chemical binding]; other site 1173027016287 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173027016288 diiron binding motif [ion binding]; other site 1173027016289 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1173027016290 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173027016291 MoaE interaction surface [polypeptide binding]; other site 1173027016292 MoeB interaction surface [polypeptide binding]; other site 1173027016293 thiocarboxylated glycine; other site 1173027016294 threonine synthase; Validated; Region: PRK07591 1173027016295 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173027016296 homodimer interface [polypeptide binding]; other site 1173027016297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027016298 catalytic residue [active] 1173027016299 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1173027016300 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173027016301 MoaE interaction surface [polypeptide binding]; other site 1173027016302 MoeB interaction surface [polypeptide binding]; other site 1173027016303 thiocarboxylated glycine; other site 1173027016304 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1173027016305 Cytochrome P450; Region: p450; cl12078 1173027016306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1173027016307 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1173027016308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1173027016309 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1173027016310 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027016311 HSP70 interaction site [polypeptide binding]; other site 1173027016312 TPR repeat; Region: TPR_11; pfam13414 1173027016313 Clp protease; Region: CLP_protease; pfam00574 1173027016314 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173027016315 oligomer interface [polypeptide binding]; other site 1173027016316 active site residues [active] 1173027016317 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1173027016318 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173027016319 oligomer interface [polypeptide binding]; other site 1173027016320 active site residues [active] 1173027016321 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173027016322 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173027016323 metal ion-dependent adhesion site (MIDAS); other site 1173027016324 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027016325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016326 active site 1173027016327 phosphorylation site [posttranslational modification] 1173027016328 intermolecular recognition site; other site 1173027016329 dimerization interface [polypeptide binding]; other site 1173027016330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016331 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027016332 active site 1173027016333 phosphorylation site [posttranslational modification] 1173027016334 intermolecular recognition site; other site 1173027016335 dimerization interface [polypeptide binding]; other site 1173027016336 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173027016337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027016338 dimerization interface [polypeptide binding]; other site 1173027016339 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027016340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027016341 dimer interface [polypeptide binding]; other site 1173027016342 putative CheW interface [polypeptide binding]; other site 1173027016343 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027016344 putative binding surface; other site 1173027016345 active site 1173027016346 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027016347 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027016348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027016349 ATP binding site [chemical binding]; other site 1173027016350 Mg2+ binding site [ion binding]; other site 1173027016351 G-X-G motif; other site 1173027016352 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027016353 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027016354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016355 active site 1173027016356 phosphorylation site [posttranslational modification] 1173027016357 intermolecular recognition site; other site 1173027016358 dimerization interface [polypeptide binding]; other site 1173027016359 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1173027016360 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1173027016361 putative active site [active] 1173027016362 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 1173027016363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027016364 FeS/SAM binding site; other site 1173027016365 HemN C-terminal domain; Region: HemN_C; pfam06969 1173027016366 spermine synthase; Region: PLN02823 1173027016367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027016368 S-adenosylmethionine binding site [chemical binding]; other site 1173027016369 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 1173027016370 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027016371 FOG: CBS domain [General function prediction only]; Region: COG0517 1173027016372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 1173027016373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027016374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027016375 dimer interface [polypeptide binding]; other site 1173027016376 phosphorylation site [posttranslational modification] 1173027016377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027016378 ATP binding site [chemical binding]; other site 1173027016379 Mg2+ binding site [ion binding]; other site 1173027016380 G-X-G motif; other site 1173027016381 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173027016382 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027016383 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173027016384 protein binding site [polypeptide binding]; other site 1173027016385 RRXRR protein; Region: RRXRR; pfam14239 1173027016386 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1173027016387 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173027016388 nucleotide binding site [chemical binding]; other site 1173027016389 NEF interaction site [polypeptide binding]; other site 1173027016390 SBD interface [polypeptide binding]; other site 1173027016391 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1173027016392 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173027016393 FMN binding site [chemical binding]; other site 1173027016394 active site 1173027016395 catalytic residues [active] 1173027016396 substrate binding site [chemical binding]; other site 1173027016397 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027016398 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173027016399 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173027016400 ferrochelatase; Reviewed; Region: hemH; PRK00035 1173027016401 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173027016402 active site 1173027016403 C-terminal domain interface [polypeptide binding]; other site 1173027016404 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173027016405 active site 1173027016406 N-terminal domain interface [polypeptide binding]; other site 1173027016407 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 1173027016408 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1173027016409 AAA domain; Region: AAA_17; pfam13207 1173027016410 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1173027016411 heterotetramer interface [polypeptide binding]; other site 1173027016412 active site pocket [active] 1173027016413 cleavage site 1173027016414 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1173027016415 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1173027016416 GatB domain; Region: GatB_Yqey; smart00845 1173027016417 putative high light inducible protein; Region: PHA02337 1173027016418 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173027016419 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1173027016420 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173027016421 Walker A/P-loop; other site 1173027016422 ATP binding site [chemical binding]; other site 1173027016423 Q-loop/lid; other site 1173027016424 ABC transporter signature motif; other site 1173027016425 Walker B; other site 1173027016426 D-loop; other site 1173027016427 H-loop/switch region; other site 1173027016428 TOBE domain; Region: TOBE_2; pfam08402 1173027016429 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 1173027016430 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173027016431 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016432 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027016433 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016434 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027016435 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016436 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016437 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 1173027016438 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 1173027016439 Repair protein; Region: Repair_PSII; pfam04536 1173027016440 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1173027016441 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1173027016442 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1173027016443 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1173027016444 active site 1173027016445 substrate binding site [chemical binding]; other site 1173027016446 catalytic site [active] 1173027016447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027016448 AAA domain; Region: AAA_22; pfam13401 1173027016449 Walker A motif; other site 1173027016450 ATP binding site [chemical binding]; other site 1173027016451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1173027016452 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1173027016453 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1173027016454 RibD C-terminal domain; Region: RibD_C; cl17279 1173027016455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027016456 HAMP domain; Region: HAMP; pfam00672 1173027016457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027016458 dimer interface [polypeptide binding]; other site 1173027016459 phosphorylation site [posttranslational modification] 1173027016460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027016461 ATP binding site [chemical binding]; other site 1173027016462 Mg2+ binding site [ion binding]; other site 1173027016463 G-X-G motif; other site 1173027016464 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 1173027016465 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173027016466 dimerization interface [polypeptide binding]; other site 1173027016467 active site 1173027016468 metal binding site [ion binding]; metal-binding site 1173027016469 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173027016470 dsRNA binding site [nucleotide binding]; other site 1173027016471 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1173027016472 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1173027016473 oligomer interface [polypeptide binding]; other site 1173027016474 metal binding site [ion binding]; metal-binding site 1173027016475 metal binding site [ion binding]; metal-binding site 1173027016476 Cl binding site [ion binding]; other site 1173027016477 aspartate ring; other site 1173027016478 basic sphincter; other site 1173027016479 putative hydrophobic gate; other site 1173027016480 periplasmic entrance; other site 1173027016481 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173027016482 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173027016483 ring oligomerisation interface [polypeptide binding]; other site 1173027016484 ATP/Mg binding site [chemical binding]; other site 1173027016485 stacking interactions; other site 1173027016486 hinge regions; other site 1173027016487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173027016488 dimerization interface [polypeptide binding]; other site 1173027016489 putative DNA binding site [nucleotide binding]; other site 1173027016490 putative Zn2+ binding site [ion binding]; other site 1173027016491 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027016492 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027016493 catalytic residues [active] 1173027016494 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1173027016495 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1173027016496 C-terminal domain interface [polypeptide binding]; other site 1173027016497 GSH binding site (G-site) [chemical binding]; other site 1173027016498 dimer interface [polypeptide binding]; other site 1173027016499 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1173027016500 N-terminal domain interface [polypeptide binding]; other site 1173027016501 putative dimer interface [polypeptide binding]; other site 1173027016502 active site 1173027016503 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1173027016504 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1173027016505 FMN binding site [chemical binding]; other site 1173027016506 active site 1173027016507 substrate binding site [chemical binding]; other site 1173027016508 catalytic residue [active] 1173027016509 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 1173027016510 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1173027016511 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 1173027016512 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1173027016513 16S/18S rRNA binding site [nucleotide binding]; other site 1173027016514 S13e-L30e interaction site [polypeptide binding]; other site 1173027016515 25S rRNA binding site [nucleotide binding]; other site 1173027016516 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1173027016517 Predicted membrane protein [Function unknown]; Region: COG2324 1173027016518 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027016519 active site 1173027016520 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1173027016521 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173027016522 active site 1173027016523 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 1173027016524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027016525 Walker A motif; other site 1173027016526 ATP binding site [chemical binding]; other site 1173027016527 Walker B motif; other site 1173027016528 arginine finger; other site 1173027016529 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173027016530 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1173027016531 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173027016532 DXD motif; other site 1173027016533 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 1173027016534 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173027016535 short chain dehydrogenase; Provisional; Region: PRK12367 1173027016536 NAD(P) binding site [chemical binding]; other site 1173027016537 active site 1173027016538 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1173027016539 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1173027016540 G1 box; other site 1173027016541 putative GEF interaction site [polypeptide binding]; other site 1173027016542 GTP/Mg2+ binding site [chemical binding]; other site 1173027016543 Switch I region; other site 1173027016544 G2 box; other site 1173027016545 G3 box; other site 1173027016546 Switch II region; other site 1173027016547 G4 box; other site 1173027016548 G5 box; other site 1173027016549 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1173027016550 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1173027016551 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173027016552 hydrophobic ligand binding site; other site 1173027016553 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1173027016554 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1173027016555 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173027016556 anti sigma factor interaction site; other site 1173027016557 regulatory phosphorylation site [posttranslational modification]; other site 1173027016558 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173027016559 Thf1-like protein; Reviewed; Region: PRK13266 1173027016560 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 1173027016561 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027016562 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027016563 catalytic residues [active] 1173027016564 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173027016565 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1173027016566 NAD(P) binding site [chemical binding]; other site 1173027016567 homotetramer interface [polypeptide binding]; other site 1173027016568 homodimer interface [polypeptide binding]; other site 1173027016569 active site 1173027016570 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173027016571 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027016572 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027016573 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027016574 active site 1173027016575 metal binding site [ion binding]; metal-binding site 1173027016576 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1173027016577 DNA photolyase; Region: DNA_photolyase; pfam00875 1173027016578 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1173027016579 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173027016580 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1173027016581 peptide binding site [polypeptide binding]; other site 1173027016582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027016583 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027016584 active site 1173027016585 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173027016586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027016587 dimer interface [polypeptide binding]; other site 1173027016588 conserved gate region; other site 1173027016589 putative PBP binding loops; other site 1173027016590 ABC-ATPase subunit interface; other site 1173027016591 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1173027016592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027016593 dimer interface [polypeptide binding]; other site 1173027016594 conserved gate region; other site 1173027016595 ABC-ATPase subunit interface; other site 1173027016596 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027016597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016598 active site 1173027016599 phosphorylation site [posttranslational modification] 1173027016600 intermolecular recognition site; other site 1173027016601 dimerization interface [polypeptide binding]; other site 1173027016602 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173027016603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173027016604 Walker A/P-loop; other site 1173027016605 ATP binding site [chemical binding]; other site 1173027016606 Q-loop/lid; other site 1173027016607 ABC transporter signature motif; other site 1173027016608 Walker B; other site 1173027016609 D-loop; other site 1173027016610 H-loop/switch region; other site 1173027016611 DevC protein; Region: devC; TIGR01185 1173027016612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027016613 FtsX-like permease family; Region: FtsX; pfam02687 1173027016614 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173027016615 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027016616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173027016617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173027016618 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1173027016619 homotrimer interaction site [polypeptide binding]; other site 1173027016620 putative active site [active] 1173027016621 AAA domain; Region: AAA_23; pfam13476 1173027016622 AAA domain; Region: AAA_21; pfam13304 1173027016623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027016624 ABC transporter signature motif; other site 1173027016625 Walker B; other site 1173027016626 D-loop; other site 1173027016627 H-loop/switch region; other site 1173027016628 TIGR02646 family protein; Region: TIGR02646 1173027016629 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173027016630 putative active site [active] 1173027016631 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173027016632 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027016633 putative active site [active] 1173027016634 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1173027016635 putative ADP-binding pocket [chemical binding]; other site 1173027016636 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016637 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027016638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027016639 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1173027016640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1173027016641 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173027016642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027016643 ABC-ATPase subunit interface; other site 1173027016644 putative PBP binding loops; other site 1173027016645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027016646 dimer interface [polypeptide binding]; other site 1173027016647 conserved gate region; other site 1173027016648 putative PBP binding loops; other site 1173027016649 ABC-ATPase subunit interface; other site 1173027016650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016651 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027016652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016653 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1173027016654 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173027016655 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173027016656 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1173027016657 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027016658 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016659 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016660 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016661 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016662 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016663 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027016664 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1173027016665 homotrimer interaction site [polypeptide binding]; other site 1173027016666 putative active site [active] 1173027016667 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1173027016668 nudix motif; other site 1173027016669 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1173027016670 Helix-turn-helix domain; Region: HTH_25; pfam13413 1173027016671 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1173027016672 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1173027016673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173027016674 RNA binding surface [nucleotide binding]; other site 1173027016675 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1173027016676 active site 1173027016677 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173027016678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027016679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016680 active site 1173027016681 phosphorylation site [posttranslational modification] 1173027016682 intermolecular recognition site; other site 1173027016683 dimerization interface [polypeptide binding]; other site 1173027016684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027016685 DNA binding residues [nucleotide binding] 1173027016686 dimerization interface [polypeptide binding]; other site 1173027016687 Ycf46; Provisional; Region: ycf46; CHL00195 1173027016688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027016689 Walker A motif; other site 1173027016690 ATP binding site [chemical binding]; other site 1173027016691 Walker B motif; other site 1173027016692 arginine finger; other site 1173027016693 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1173027016694 AMIN domain; Region: AMIN; pfam11741 1173027016695 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173027016696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173027016697 active site 1173027016698 metal binding site [ion binding]; metal-binding site 1173027016699 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173027016700 FAD binding domain; Region: FAD_binding_4; pfam01565 1173027016701 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1173027016702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027016703 Cysteine-rich domain; Region: CCG; pfam02754 1173027016704 Cysteine-rich domain; Region: CCG; pfam02754 1173027016705 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173027016706 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173027016707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016708 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016710 binding surface 1173027016711 TPR motif; other site 1173027016712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016713 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016715 binding surface 1173027016716 TPR motif; other site 1173027016717 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027016720 binding surface 1173027016721 TPR motif; other site 1173027016722 CHAT domain; Region: CHAT; pfam12770 1173027016723 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173027016724 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173027016725 metal-binding site [ion binding] 1173027016726 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027016727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027016728 motif II; other site 1173027016729 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027016730 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027016731 phosphopeptide binding site; other site 1173027016732 thymidylate kinase; Validated; Region: tmk; PRK00698 1173027016733 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1173027016734 TMP-binding site; other site 1173027016735 ATP-binding site [chemical binding]; other site 1173027016736 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1173027016737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027016738 Walker A motif; other site 1173027016739 ATP binding site [chemical binding]; other site 1173027016740 Walker B motif; other site 1173027016741 arginine finger; other site 1173027016742 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173027016743 ligand-binding site [chemical binding]; other site 1173027016744 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173027016745 Chromate transporter; Region: Chromate_transp; pfam02417 1173027016746 Chromate transporter; Region: Chromate_transp; pfam02417 1173027016747 maltose O-acetyltransferase; Provisional; Region: PRK10092 1173027016748 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1173027016749 active site 1173027016750 substrate binding site [chemical binding]; other site 1173027016751 trimer interface [polypeptide binding]; other site 1173027016752 CoA binding site [chemical binding]; other site 1173027016753 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1173027016754 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027016755 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173027016756 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173027016757 Walker A/P-loop; other site 1173027016758 ATP binding site [chemical binding]; other site 1173027016759 Q-loop/lid; other site 1173027016760 ABC transporter signature motif; other site 1173027016761 Walker B; other site 1173027016762 D-loop; other site 1173027016763 H-loop/switch region; other site 1173027016764 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173027016765 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173027016766 substrate binding pocket [chemical binding]; other site 1173027016767 membrane-bound complex binding site; other site 1173027016768 hinge residues; other site 1173027016769 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1173027016770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027016771 dimer interface [polypeptide binding]; other site 1173027016772 conserved gate region; other site 1173027016773 putative PBP binding loops; other site 1173027016774 ABC-ATPase subunit interface; other site 1173027016775 CsbD-like; Region: CsbD; pfam05532 1173027016776 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027016777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016778 active site 1173027016779 phosphorylation site [posttranslational modification] 1173027016780 intermolecular recognition site; other site 1173027016781 dimerization interface [polypeptide binding]; other site 1173027016782 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027016783 cyclase homology domain; Region: CHD; cd07302 1173027016784 nucleotidyl binding site; other site 1173027016785 metal binding site [ion binding]; metal-binding site 1173027016786 dimer interface [polypeptide binding]; other site 1173027016787 PAS fold; Region: PAS_7; pfam12860 1173027016788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027016789 GAF domain; Region: GAF_3; pfam13492 1173027016790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027016791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027016792 dimer interface [polypeptide binding]; other site 1173027016793 phosphorylation site [posttranslational modification] 1173027016794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027016795 ATP binding site [chemical binding]; other site 1173027016796 Mg2+ binding site [ion binding]; other site 1173027016797 G-X-G motif; other site 1173027016798 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027016799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016800 active site 1173027016801 phosphorylation site [posttranslational modification] 1173027016802 intermolecular recognition site; other site 1173027016803 dimerization interface [polypeptide binding]; other site 1173027016804 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1173027016805 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173027016806 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173027016807 dimer interface [polypeptide binding]; other site 1173027016808 [2Fe-2S] cluster binding site [ion binding]; other site 1173027016809 S-layer homology domain; Region: SLH; pfam00395 1173027016810 S-layer homology domain; Region: SLH; pfam00395 1173027016811 S-layer homology domain; Region: SLH; pfam00395 1173027016812 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173027016813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016815 binding surface 1173027016816 TPR motif; other site 1173027016817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016821 binding surface 1173027016822 TPR motif; other site 1173027016823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016824 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016825 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173027016826 active site 1173027016827 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173027016828 active site 1173027016829 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173027016830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027016831 HSP70 interaction site [polypeptide binding]; other site 1173027016832 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173027016833 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173027016834 dimer interface [polypeptide binding]; other site 1173027016835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027016836 catalytic residue [active] 1173027016837 Predicted transcriptional regulator [Transcription]; Region: COG1959 1173027016838 Transcriptional regulator; Region: Rrf2; pfam02082 1173027016839 S-layer homology domain; Region: SLH; pfam00395 1173027016840 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027016841 S-layer homology domain; Region: SLH; pfam00395 1173027016842 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173027016843 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1173027016844 aromatic arch; other site 1173027016845 DCoH dimer interaction site [polypeptide binding]; other site 1173027016846 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1173027016847 DCoH tetramer interaction site [polypeptide binding]; other site 1173027016848 substrate binding site [chemical binding]; other site 1173027016849 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173027016850 D1 interface; other site 1173027016851 chlorophyll binding site; other site 1173027016852 pheophytin binding site; other site 1173027016853 beta carotene binding site; other site 1173027016854 cytochrome b559 beta interface; other site 1173027016855 quinone binding site; other site 1173027016856 cytochrome b559 alpha interface; other site 1173027016857 protein J interface; other site 1173027016858 protein H interface; other site 1173027016859 protein X interface; other site 1173027016860 core light harvesting protein interface; other site 1173027016861 protein L interface; other site 1173027016862 CP43 interface; other site 1173027016863 protein T interface; other site 1173027016864 Fe binding site [ion binding]; other site 1173027016865 protein M interface; other site 1173027016866 Mn-stabilizing polypeptide interface; other site 1173027016867 bromide binding site; other site 1173027016868 cytochrome c-550 interface; other site 1173027016869 hypothetical protein; Provisional; Region: PRK13683 1173027016870 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173027016871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173027016872 Walker A/P-loop; other site 1173027016873 ATP binding site [chemical binding]; other site 1173027016874 Q-loop/lid; other site 1173027016875 ABC transporter signature motif; other site 1173027016876 Walker B; other site 1173027016877 D-loop; other site 1173027016878 H-loop/switch region; other site 1173027016879 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1173027016880 YGGT family; Region: YGGT; pfam02325 1173027016881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027016882 active site 1173027016883 carotene isomerase; Region: carot_isom; TIGR02730 1173027016884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027016885 CHAT domain; Region: CHAT; cl17868 1173027016886 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027016887 phosphopeptide binding site; other site 1173027016888 Double zinc ribbon; Region: DZR; pfam12773 1173027016889 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173027016890 active site 1173027016891 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 1173027016892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027016893 GAF domain; Region: GAF; pfam01590 1173027016894 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027016895 GAF domain; Region: GAF; pfam01590 1173027016896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027016897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027016898 dimer interface [polypeptide binding]; other site 1173027016899 phosphorylation site [posttranslational modification] 1173027016900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027016901 ATP binding site [chemical binding]; other site 1173027016902 Mg2+ binding site [ion binding]; other site 1173027016903 G-X-G motif; other site 1173027016904 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173027016905 ABC1 family; Region: ABC1; cl17513 1173027016906 dihydroorotase; Provisional; Region: PRK07369 1173027016907 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173027016908 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1173027016909 active site 1173027016910 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173027016911 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173027016912 Catalytic site [active] 1173027016913 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173027016914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173027016915 Catalytic site [active] 1173027016916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173027016917 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1173027016918 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173027016919 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173027016920 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1173027016921 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173027016922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173027016923 Divalent cation transporter; Region: MgtE; pfam01769 1173027016924 Sporulation and spore germination; Region: Germane; cl11253 1173027016925 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1173027016926 active site 1173027016927 DNA binding site [nucleotide binding] 1173027016928 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1173027016929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173027016930 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 1173027016931 active site 1173027016932 catalytic residues [active] 1173027016933 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1173027016934 intersubunit interface [polypeptide binding]; other site 1173027016935 active site 1173027016936 zinc binding site [ion binding]; other site 1173027016937 Na+ binding site [ion binding]; other site 1173027016938 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1173027016939 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1173027016940 dimer interface [polypeptide binding]; other site 1173027016941 anticodon binding site; other site 1173027016942 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173027016943 homodimer interface [polypeptide binding]; other site 1173027016944 motif 1; other site 1173027016945 active site 1173027016946 motif 2; other site 1173027016947 GAD domain; Region: GAD; pfam02938 1173027016948 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173027016949 motif 3; other site 1173027016950 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173027016951 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1173027016952 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173027016953 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1173027016954 G1 box; other site 1173027016955 GTP/Mg2+ binding site [chemical binding]; other site 1173027016956 G2 box; other site 1173027016957 Switch I region; other site 1173027016958 G3 box; other site 1173027016959 Switch II region; other site 1173027016960 G4 box; other site 1173027016961 G5 box; other site 1173027016962 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027016963 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173027016964 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173027016965 Walker A/P-loop; other site 1173027016966 ATP binding site [chemical binding]; other site 1173027016967 Q-loop/lid; other site 1173027016968 ABC transporter signature motif; other site 1173027016969 Walker B; other site 1173027016970 D-loop; other site 1173027016971 H-loop/switch region; other site 1173027016972 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173027016973 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1173027016974 FtsX-like permease family; Region: FtsX; pfam02687 1173027016975 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173027016976 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027016977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016978 binding surface 1173027016979 TPR repeat; Region: TPR_11; pfam13414 1173027016980 TPR motif; other site 1173027016981 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027016982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027016983 binding surface 1173027016984 TPR motif; other site 1173027016985 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027016986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027016987 active site 1173027016988 phosphorylation site [posttranslational modification] 1173027016989 intermolecular recognition site; other site 1173027016990 dimerization interface [polypeptide binding]; other site 1173027016991 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 1173027016992 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173027016993 CAP-like domain; other site 1173027016994 active site 1173027016995 primary dimer interface [polypeptide binding]; other site 1173027016996 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027016997 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027016998 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173027016999 Caspase domain; Region: Peptidase_C14; pfam00656 1173027017000 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027017001 putative active site [active] 1173027017002 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027017003 Double zinc ribbon; Region: DZR; pfam12773 1173027017004 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027017005 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027017006 active site 1173027017007 ATP binding site [chemical binding]; other site 1173027017008 substrate binding site [chemical binding]; other site 1173027017009 activation loop (A-loop); other site 1173027017010 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1173027017011 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1173027017012 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1173027017013 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1173027017014 shikimate binding site; other site 1173027017015 NAD(P) binding site [chemical binding]; other site 1173027017016 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173027017017 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173027017018 substrate binding pocket [chemical binding]; other site 1173027017019 chain length determination region; other site 1173027017020 substrate-Mg2+ binding site; other site 1173027017021 catalytic residues [active] 1173027017022 aspartate-rich region 1; other site 1173027017023 active site lid residues [active] 1173027017024 aspartate-rich region 2; other site 1173027017025 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1173027017026 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1173027017027 putative sugar binding sites [chemical binding]; other site 1173027017028 Q-X-W motif; other site 1173027017029 Jacalin-like lectin domain; Region: Jacalin; smart00915 1173027017030 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173027017031 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173027017032 active site 1173027017033 TDP-binding site; other site 1173027017034 acceptor substrate-binding pocket; other site 1173027017035 homodimer interface [polypeptide binding]; other site 1173027017036 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173027017037 catalytic core [active] 1173027017038 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173027017039 catalytic core [active] 1173027017040 CAAX protease self-immunity; Region: Abi; pfam02517 1173027017041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 1173027017042 putative homotetramer interface [polypeptide binding]; other site 1173027017043 putative homodimer interface [polypeptide binding]; other site 1173027017044 putative allosteric switch controlling residues; other site 1173027017045 putative metal binding site [ion binding]; other site 1173027017046 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173027017047 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027017048 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173027017049 protein binding site [polypeptide binding]; other site 1173027017050 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1173027017051 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173027017052 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1173027017053 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173027017054 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1173027017055 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173027017056 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1173027017057 DNA binding site [nucleotide binding] 1173027017058 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1173027017059 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1173027017060 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1173027017061 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1173027017062 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173027017063 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1173027017064 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173027017065 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173027017066 RPB1 interaction site [polypeptide binding]; other site 1173027017067 RPB10 interaction site [polypeptide binding]; other site 1173027017068 RPB11 interaction site [polypeptide binding]; other site 1173027017069 RPB3 interaction site [polypeptide binding]; other site 1173027017070 RPB12 interaction site [polypeptide binding]; other site 1173027017071 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173027017072 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1173027017073 active site 1173027017074 ribosomal protein S20; Region: rps20; CHL00102 1173027017075 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1173027017076 histidinol dehydrogenase; Region: hisD; TIGR00069 1173027017077 NAD binding site [chemical binding]; other site 1173027017078 dimerization interface [polypeptide binding]; other site 1173027017079 product binding site; other site 1173027017080 substrate binding site [chemical binding]; other site 1173027017081 zinc binding site [ion binding]; other site 1173027017082 catalytic residues [active] 1173027017083 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027017084 Ligand Binding Site [chemical binding]; other site 1173027017085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017086 PAS fold; Region: PAS_3; pfam08447 1173027017087 putative active site [active] 1173027017088 heme pocket [chemical binding]; other site 1173027017089 PAS fold; Region: PAS_4; pfam08448 1173027017090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017091 putative active site [active] 1173027017092 heme pocket [chemical binding]; other site 1173027017093 PAS domain S-box; Region: sensory_box; TIGR00229 1173027017094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017095 putative active site [active] 1173027017096 heme pocket [chemical binding]; other site 1173027017097 PAS fold; Region: PAS_4; pfam08448 1173027017098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017099 putative active site [active] 1173027017100 heme pocket [chemical binding]; other site 1173027017101 PAS fold; Region: PAS_4; pfam08448 1173027017102 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173027017103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017104 putative active site [active] 1173027017105 heme pocket [chemical binding]; other site 1173027017106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017107 putative active site [active] 1173027017108 heme pocket [chemical binding]; other site 1173027017109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027017110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017111 dimer interface [polypeptide binding]; other site 1173027017112 phosphorylation site [posttranslational modification] 1173027017113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017114 ATP binding site [chemical binding]; other site 1173027017115 Mg2+ binding site [ion binding]; other site 1173027017116 G-X-G motif; other site 1173027017117 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173027017118 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173027017119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027017120 ligand binding site [chemical binding]; other site 1173027017121 flexible hinge region; other site 1173027017122 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173027017123 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173027017124 putative active site [active] 1173027017125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027017126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027017127 Walker A/P-loop; other site 1173027017128 ATP binding site [chemical binding]; other site 1173027017129 Q-loop/lid; other site 1173027017130 ABC transporter signature motif; other site 1173027017131 Walker B; other site 1173027017132 D-loop; other site 1173027017133 H-loop/switch region; other site 1173027017134 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173027017135 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173027017136 catalytic residues [active] 1173027017137 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1173027017138 catalytic residue [active] 1173027017139 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173027017140 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173027017141 NAD(P) binding site [chemical binding]; other site 1173027017142 putative active site [active] 1173027017143 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173027017144 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173027017145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027017146 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173027017147 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027017148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173027017149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027017150 Ankyrin repeat; Region: Ank; pfam00023 1173027017151 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1173027017152 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173027017153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027017154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173027017155 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173027017156 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; pfam02366 1173027017157 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1173027017158 Cupin-like domain; Region: Cupin_8; pfam13621 1173027017159 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1173027017160 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173027017161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027017162 active site 1173027017163 Protein kinase domain; Region: Pkinase; pfam00069 1173027017164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027017165 active site 1173027017166 ATP binding site [chemical binding]; other site 1173027017167 substrate binding site [chemical binding]; other site 1173027017168 activation loop (A-loop); other site 1173027017169 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1173027017170 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027017171 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027017172 putative active site [active] 1173027017173 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173027017174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027017175 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1173027017176 active site 1173027017177 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1173027017178 putative RNAase interaction site [polypeptide binding]; other site 1173027017179 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1173027017180 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1173027017181 nudix motif; other site 1173027017182 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 1173027017183 active site 1173027017184 catalytic site [active] 1173027017185 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1173027017186 Predicted membrane protein [Function unknown]; Region: COG2119 1173027017187 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173027017188 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173027017189 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1173027017190 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173027017191 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173027017192 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1173027017193 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173027017194 domain interfaces; other site 1173027017195 active site 1173027017196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027017197 non-specific DNA binding site [nucleotide binding]; other site 1173027017198 salt bridge; other site 1173027017199 sequence-specific DNA binding site [nucleotide binding]; other site 1173027017200 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1173027017201 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1173027017202 generic binding surface II; other site 1173027017203 ssDNA binding site; other site 1173027017204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027017205 ATP binding site [chemical binding]; other site 1173027017206 putative Mg++ binding site [ion binding]; other site 1173027017207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027017208 nucleotide binding region [chemical binding]; other site 1173027017209 ATP-binding site [chemical binding]; other site 1173027017210 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1173027017211 UBA/TS-N domain; Region: UBA; pfam00627 1173027017212 Elongation factor TS; Region: EF_TS; pfam00889 1173027017213 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1173027017214 rRNA interaction site [nucleotide binding]; other site 1173027017215 S8 interaction site; other site 1173027017216 putative laminin-1 binding site; other site 1173027017217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017218 GAF domain; Region: GAF; pfam01590 1173027017219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027017220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017221 dimer interface [polypeptide binding]; other site 1173027017222 phosphorylation site [posttranslational modification] 1173027017223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017224 ATP binding site [chemical binding]; other site 1173027017225 Mg2+ binding site [ion binding]; other site 1173027017226 G-X-G motif; other site 1173027017227 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027017228 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027017229 active site 1173027017230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027017231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1173027017232 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1173027017233 substrate binding site [chemical binding]; other site 1173027017234 oxyanion hole (OAH) forming residues; other site 1173027017235 trimer interface [polypeptide binding]; other site 1173027017236 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027017237 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027017238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173027017239 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173027017240 catalytic residues [active] 1173027017241 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 1173027017242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027017243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027017244 homodimer interface [polypeptide binding]; other site 1173027017245 catalytic residue [active] 1173027017246 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1173027017247 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1173027017248 Zn binding site [ion binding]; other site 1173027017249 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1173027017250 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1173027017251 GIY-YIG motif/motif A; other site 1173027017252 active site 1173027017253 catalytic site [active] 1173027017254 putative DNA binding site [nucleotide binding]; other site 1173027017255 metal binding site [ion binding]; metal-binding site 1173027017256 UvrB/uvrC motif; Region: UVR; pfam02151 1173027017257 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1173027017258 Transposase IS200 like; Region: Y1_Tnp; cl00848 1173027017259 TPR repeat; Region: TPR_11; pfam13414 1173027017260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017261 binding surface 1173027017262 TPR motif; other site 1173027017263 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173027017264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017265 binding surface 1173027017266 TPR motif; other site 1173027017267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017268 binding surface 1173027017269 TPR motif; other site 1173027017270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017271 binding surface 1173027017272 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027017273 TPR motif; other site 1173027017274 TPR repeat; Region: TPR_11; pfam13414 1173027017275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017276 binding surface 1173027017277 TPR motif; other site 1173027017278 TPR repeat; Region: TPR_11; pfam13414 1173027017279 CHAT domain; Region: CHAT; pfam12770 1173027017280 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1173027017281 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173027017282 active site 1173027017283 HIGH motif; other site 1173027017284 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173027017285 active site 1173027017286 KMSKS motif; other site 1173027017287 glycogen synthase; Provisional; Region: glgA; PRK00654 1173027017288 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173027017289 ADP-binding pocket [chemical binding]; other site 1173027017290 homodimer interface [polypeptide binding]; other site 1173027017291 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173027017292 Protein of unknown function (DUF565); Region: DUF565; pfam04483 1173027017293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173027017294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173027017295 active site 1173027017296 catalytic tetrad [active] 1173027017297 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027017298 putative active site [active] 1173027017299 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1173027017300 GIY-YIG motif/motif A; other site 1173027017301 active site 1173027017302 catalytic site [active] 1173027017303 metal binding site [ion binding]; metal-binding site 1173027017304 XisI protein; Region: XisI; pfam08869 1173027017305 XisH protein; Region: XisH; pfam08814 1173027017306 S-layer homology domain; Region: SLH; pfam00395 1173027017307 S-layer homology domain; Region: SLH; pfam00395 1173027017308 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027017309 Predicted integral membrane protein [Function unknown]; Region: COG5542 1173027017310 glutathione reductase; Validated; Region: PRK06116 1173027017311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173027017312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027017313 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173027017314 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173027017315 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1173027017316 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1173027017317 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1173027017318 active site 1173027017319 (T/H)XGH motif; other site 1173027017320 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1173027017321 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173027017322 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173027017323 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1173027017324 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173027017325 Moco binding site; other site 1173027017326 metal coordination site [ion binding]; other site 1173027017327 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1173027017328 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1173027017329 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173027017330 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173027017331 putative dimer interface [polypeptide binding]; other site 1173027017332 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173027017333 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173027017334 Sulfatase; Region: Sulfatase; cl17466 1173027017335 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1173027017336 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1173027017337 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1173027017338 N- and C-terminal domain interface [polypeptide binding]; other site 1173027017339 active site 1173027017340 MgATP binding site [chemical binding]; other site 1173027017341 catalytic site [active] 1173027017342 metal binding site [ion binding]; metal-binding site 1173027017343 glycerol binding site [chemical binding]; other site 1173027017344 homotetramer interface [polypeptide binding]; other site 1173027017345 homodimer interface [polypeptide binding]; other site 1173027017346 FBP binding site [chemical binding]; other site 1173027017347 protein IIAGlc interface [polypeptide binding]; other site 1173027017348 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 1173027017349 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1173027017350 Ycf39; Provisional; Region: ycf39; CHL00194 1173027017351 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173027017352 NAD(P) binding site [chemical binding]; other site 1173027017353 putative active site [active] 1173027017354 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 1173027017355 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173027017356 PAS fold; Region: PAS_4; pfam08448 1173027017357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017358 putative active site [active] 1173027017359 heme pocket [chemical binding]; other site 1173027017360 PAS domain; Region: PAS_9; pfam13426 1173027017361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017362 PAS fold; Region: PAS_3; pfam08447 1173027017363 putative active site [active] 1173027017364 heme pocket [chemical binding]; other site 1173027017365 PAS fold; Region: PAS_4; pfam08448 1173027017366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017369 PAS fold; Region: PAS_3; pfam08447 1173027017370 putative active site [active] 1173027017371 heme pocket [chemical binding]; other site 1173027017372 PAS fold; Region: PAS_4; pfam08448 1173027017373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017374 putative active site [active] 1173027017375 heme pocket [chemical binding]; other site 1173027017376 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017377 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027017379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017380 dimer interface [polypeptide binding]; other site 1173027017381 phosphorylation site [posttranslational modification] 1173027017382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017383 ATP binding site [chemical binding]; other site 1173027017384 Mg2+ binding site [ion binding]; other site 1173027017385 G-X-G motif; other site 1173027017386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027017387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017388 active site 1173027017389 phosphorylation site [posttranslational modification] 1173027017390 intermolecular recognition site; other site 1173027017391 dimerization interface [polypeptide binding]; other site 1173027017392 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027017393 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1173027017394 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027017395 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027017396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027017397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027017398 ligand binding site [chemical binding]; other site 1173027017399 flexible hinge region; other site 1173027017400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027017401 dimerization interface [polypeptide binding]; other site 1173027017402 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027017403 cyclase homology domain; Region: CHD; cd07302 1173027017404 nucleotidyl binding site; other site 1173027017405 metal binding site [ion binding]; metal-binding site 1173027017406 dimer interface [polypeptide binding]; other site 1173027017407 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1173027017408 heme-binding site [chemical binding]; other site 1173027017409 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173027017410 Hemerythrin; Region: Hemerythrin; cd12107 1173027017411 Fe binding site [ion binding]; other site 1173027017412 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173027017413 Ca2+ binding site [ion binding]; other site 1173027017414 Hemerythrin; Region: Hemerythrin; cd12107 1173027017415 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173027017416 EF-hand domain pair; Region: EF_hand_5; pfam13499 1173027017417 Ca2+ binding site [ion binding]; other site 1173027017418 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027017419 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017420 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017421 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017422 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017423 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017424 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027017425 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027017426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027017427 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027017428 structural tetrad; other site 1173027017429 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027017430 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027017431 structural tetrad; other site 1173027017432 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027017433 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1173027017434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173027017435 multidrug efflux protein; Reviewed; Region: PRK01766 1173027017436 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173027017437 cation binding site [ion binding]; other site 1173027017438 EamA-like transporter family; Region: EamA; pfam00892 1173027017439 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173027017440 EamA-like transporter family; Region: EamA; pfam00892 1173027017441 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173027017442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027017443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173027017444 NAD(P) binding site [chemical binding]; other site 1173027017445 active site 1173027017446 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1173027017447 EF-hand domain pair; Region: EF_hand_5; pfam13499 1173027017448 Ca2+ binding site [ion binding]; other site 1173027017449 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1173027017450 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1173027017451 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1173027017452 FAD binding pocket [chemical binding]; other site 1173027017453 conserved FAD binding motif [chemical binding]; other site 1173027017454 phosphate binding motif [ion binding]; other site 1173027017455 beta-alpha-beta structure motif; other site 1173027017456 NAD binding pocket [chemical binding]; other site 1173027017457 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1173027017458 active site 1173027017459 dimer interface [polypeptide binding]; other site 1173027017460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017461 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017462 active site 1173027017463 phosphorylation site [posttranslational modification] 1173027017464 intermolecular recognition site; other site 1173027017465 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027017466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017467 putative active site [active] 1173027017468 heme pocket [chemical binding]; other site 1173027017469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017470 dimer interface [polypeptide binding]; other site 1173027017471 phosphorylation site [posttranslational modification] 1173027017472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017473 ATP binding site [chemical binding]; other site 1173027017474 Mg2+ binding site [ion binding]; other site 1173027017475 G-X-G motif; other site 1173027017476 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017478 active site 1173027017479 phosphorylation site [posttranslational modification] 1173027017480 intermolecular recognition site; other site 1173027017481 dimerization interface [polypeptide binding]; other site 1173027017482 PAS domain S-box; Region: sensory_box; TIGR00229 1173027017483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017484 putative active site [active] 1173027017485 heme pocket [chemical binding]; other site 1173027017486 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017487 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017488 PAS domain S-box; Region: sensory_box; TIGR00229 1173027017489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017490 putative active site [active] 1173027017491 heme pocket [chemical binding]; other site 1173027017492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027017493 PAS domain; Region: PAS_9; pfam13426 1173027017494 putative active site [active] 1173027017495 heme pocket [chemical binding]; other site 1173027017496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017497 dimer interface [polypeptide binding]; other site 1173027017498 phosphorylation site [posttranslational modification] 1173027017499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017500 ATP binding site [chemical binding]; other site 1173027017501 Mg2+ binding site [ion binding]; other site 1173027017502 G-X-G motif; other site 1173027017503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173027017504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017505 active site 1173027017506 phosphorylation site [posttranslational modification] 1173027017507 intermolecular recognition site; other site 1173027017508 dimerization interface [polypeptide binding]; other site 1173027017509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173027017510 DNA binding site [nucleotide binding] 1173027017511 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173027017512 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173027017513 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173027017514 homodimer interface [polypeptide binding]; other site 1173027017515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027017516 catalytic residue [active] 1173027017517 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1173027017518 active site 1173027017519 ribulose/triose binding site [chemical binding]; other site 1173027017520 phosphate binding site [ion binding]; other site 1173027017521 substrate (anthranilate) binding pocket [chemical binding]; other site 1173027017522 product (indole) binding pocket [chemical binding]; other site 1173027017523 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1173027017524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173027017525 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173027017526 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1173027017527 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1173027017528 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173027017529 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1173027017530 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1173027017531 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1173027017532 hinge; other site 1173027017533 active site 1173027017534 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1173027017535 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1173027017536 putative NAD(P) binding site [chemical binding]; other site 1173027017537 putative active site [active] 1173027017538 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173027017539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027017540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027017541 ligand binding site [chemical binding]; other site 1173027017542 flexible hinge region; other site 1173027017543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017544 dimer interface [polypeptide binding]; other site 1173027017545 phosphorylation site [posttranslational modification] 1173027017546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017547 ATP binding site [chemical binding]; other site 1173027017548 Mg2+ binding site [ion binding]; other site 1173027017549 G-X-G motif; other site 1173027017550 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 1173027017551 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173027017552 dimer interface [polypeptide binding]; other site 1173027017553 active site 1173027017554 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173027017555 active site 1173027017556 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 1173027017557 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173027017558 D1 interface; other site 1173027017559 chlorophyll binding site; other site 1173027017560 pheophytin binding site; other site 1173027017561 beta carotene binding site; other site 1173027017562 cytochrome b559 beta interface; other site 1173027017563 quinone binding site; other site 1173027017564 cytochrome b559 alpha interface; other site 1173027017565 protein J interface; other site 1173027017566 protein H interface; other site 1173027017567 protein X interface; other site 1173027017568 core light harvesting protein interface; other site 1173027017569 protein L interface; other site 1173027017570 CP43 interface; other site 1173027017571 protein T interface; other site 1173027017572 Fe binding site [ion binding]; other site 1173027017573 protein M interface; other site 1173027017574 Mn-stabilizing polypeptide interface; other site 1173027017575 bromide binding site; other site 1173027017576 cytochrome c-550 interface; other site 1173027017577 photosystem II 44 kDa protein; Region: psbC; CHL00035 1173027017578 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 1173027017579 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017580 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017581 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017582 Phytochrome region; Region: PHY; pfam00360 1173027017583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027017584 dimer interface [polypeptide binding]; other site 1173027017585 phosphorylation site [posttranslational modification] 1173027017586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017587 ATP binding site [chemical binding]; other site 1173027017588 Mg2+ binding site [ion binding]; other site 1173027017589 G-X-G motif; other site 1173027017590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017591 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027017592 active site 1173027017593 phosphorylation site [posttranslational modification] 1173027017594 intermolecular recognition site; other site 1173027017595 dimerization interface [polypeptide binding]; other site 1173027017596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017597 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017598 active site 1173027017599 phosphorylation site [posttranslational modification] 1173027017600 intermolecular recognition site; other site 1173027017601 dimerization interface [polypeptide binding]; other site 1173027017602 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173027017603 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173027017604 putative acyl-acceptor binding pocket; other site 1173027017605 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173027017606 nucleoside/Zn binding site; other site 1173027017607 dimer interface [polypeptide binding]; other site 1173027017608 catalytic motif [active] 1173027017609 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173027017610 GSH binding site [chemical binding]; other site 1173027017611 catalytic residues [active] 1173027017612 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1173027017613 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1173027017614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017615 S-adenosylmethionine binding site [chemical binding]; other site 1173027017616 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1173027017617 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027017618 active site 1173027017619 metal binding site [ion binding]; metal-binding site 1173027017620 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173027017621 active site 1173027017622 metal binding site [ion binding]; metal-binding site 1173027017623 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1173027017624 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1173027017625 putative active site [active] 1173027017626 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1173027017627 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1173027017628 tRNA; other site 1173027017629 putative tRNA binding site [nucleotide binding]; other site 1173027017630 putative NADP binding site [chemical binding]; other site 1173027017631 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1173027017632 hypothetical protein; Provisional; Region: PRK02509 1173027017633 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1173027017634 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173027017635 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173027017636 putative active site [active] 1173027017637 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027017638 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173027017639 putative metal binding site; other site 1173027017640 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017641 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1173027017642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017643 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173027017644 putative ADP-binding pocket [chemical binding]; other site 1173027017645 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017646 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173027017647 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027017648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017650 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017652 S-adenosylmethionine binding site [chemical binding]; other site 1173027017653 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1173027017654 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173027017655 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1173027017656 GDP-Fucose binding site [chemical binding]; other site 1173027017657 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173027017658 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 1173027017659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173027017660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017661 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027017662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017663 S-adenosylmethionine binding site [chemical binding]; other site 1173027017664 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017666 S-adenosylmethionine binding site [chemical binding]; other site 1173027017667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1173027017668 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1173027017669 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027017670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017671 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027017672 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1173027017673 metal-binding site 1173027017674 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173027017675 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173027017676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017677 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173027017678 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017680 S-adenosylmethionine binding site [chemical binding]; other site 1173027017681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017682 S-adenosylmethionine binding site [chemical binding]; other site 1173027017683 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1173027017684 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173027017685 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173027017686 Walker A/P-loop; other site 1173027017687 ATP binding site [chemical binding]; other site 1173027017688 Q-loop/lid; other site 1173027017689 ABC transporter signature motif; other site 1173027017690 Walker B; other site 1173027017691 D-loop; other site 1173027017692 H-loop/switch region; other site 1173027017693 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173027017694 putative carbohydrate binding site [chemical binding]; other site 1173027017695 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173027017696 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173027017697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017698 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173027017699 Chain length determinant protein; Region: Wzz; cl15801 1173027017700 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027017701 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027017702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017703 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173027017704 putative ADP-binding pocket [chemical binding]; other site 1173027017705 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1173027017706 active site 1173027017707 catalytic triad [active] 1173027017708 oxyanion hole [active] 1173027017709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017710 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173027017711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017712 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027017713 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017715 S-adenosylmethionine binding site [chemical binding]; other site 1173027017716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017717 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027017718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173027017719 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173027017720 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173027017721 cyanophycin synthetase; Provisional; Region: PRK14016 1173027017722 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027017723 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173027017724 proposed catalytic triad [active] 1173027017725 active site nucleophile [active] 1173027017726 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1173027017727 spermidine synthase; Provisional; Region: PRK03612 1173027017728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017729 S-adenosylmethionine binding site [chemical binding]; other site 1173027017730 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027017731 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173027017732 ligand binding site [chemical binding]; other site 1173027017733 flexible hinge region; other site 1173027017734 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027017735 putative switch regulator; other site 1173027017736 non-specific DNA interactions [nucleotide binding]; other site 1173027017737 DNA binding site [nucleotide binding] 1173027017738 sequence specific DNA binding site [nucleotide binding]; other site 1173027017739 putative cAMP binding site [chemical binding]; other site 1173027017740 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173027017741 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027017742 hybrid cluster protein; Provisional; Region: PRK05290 1173027017743 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173027017744 ACS interaction site; other site 1173027017745 CODH interaction site; other site 1173027017746 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1173027017747 hybrid metal cluster; other site 1173027017748 AAA ATPase domain; Region: AAA_16; pfam13191 1173027017749 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1173027017750 S4 domain; Region: S4_2; pfam13275 1173027017751 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173027017752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017753 S-adenosylmethionine binding site [chemical binding]; other site 1173027017754 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 1173027017755 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173027017756 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173027017757 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173027017758 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1173027017759 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173027017760 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027017761 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173027017762 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1173027017763 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027017764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027017765 TPR motif; other site 1173027017766 Intrinsic membrane protein PufX; Region: RhodobacterPufX; pfam11511 1173027017767 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1173027017768 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1173027017769 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1173027017770 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1173027017771 putative lipid kinase; Reviewed; Region: PRK00861 1173027017772 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173027017773 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173027017774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173027017775 Zn2+ binding site [ion binding]; other site 1173027017776 Mg2+ binding site [ion binding]; other site 1173027017777 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1173027017778 synthetase active site [active] 1173027017779 NTP binding site [chemical binding]; other site 1173027017780 metal binding site [ion binding]; metal-binding site 1173027017781 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1173027017782 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1173027017783 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027017784 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1173027017785 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173027017786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027017787 Walker A/P-loop; other site 1173027017788 ATP binding site [chemical binding]; other site 1173027017789 Q-loop/lid; other site 1173027017790 ABC transporter signature motif; other site 1173027017791 Walker B; other site 1173027017792 D-loop; other site 1173027017793 H-loop/switch region; other site 1173027017794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173027017795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027017796 Walker A/P-loop; other site 1173027017797 ATP binding site [chemical binding]; other site 1173027017798 Q-loop/lid; other site 1173027017799 ABC transporter signature motif; other site 1173027017800 Walker B; other site 1173027017801 D-loop; other site 1173027017802 H-loop/switch region; other site 1173027017803 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1173027017804 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173027017805 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173027017806 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173027017807 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173027017808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173027017809 active site 1173027017810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173027017811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027017812 dimer interface [polypeptide binding]; other site 1173027017813 conserved gate region; other site 1173027017814 putative PBP binding loops; other site 1173027017815 ABC-ATPase subunit interface; other site 1173027017816 proton extrusion protein PcxA; Provisional; Region: PRK02507 1173027017817 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173027017818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027017819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027017820 active site 1173027017821 ATP binding site [chemical binding]; other site 1173027017822 substrate binding site [chemical binding]; other site 1173027017823 activation loop (A-loop); other site 1173027017824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027017825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027017826 active site 1173027017827 ATP binding site [chemical binding]; other site 1173027017828 substrate binding site [chemical binding]; other site 1173027017829 activation loop (A-loop); other site 1173027017830 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027017831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027017832 active site 1173027017833 ATP binding site [chemical binding]; other site 1173027017834 substrate binding site [chemical binding]; other site 1173027017835 activation loop (A-loop); other site 1173027017836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027017837 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173027017838 putative ADP-binding pocket [chemical binding]; other site 1173027017839 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027017840 phosphopeptide binding site; other site 1173027017841 Transglycosylase; Region: Transgly; pfam00912 1173027017842 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173027017843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1173027017844 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173027017845 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173027017846 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1173027017847 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173027017848 NAD binding site [chemical binding]; other site 1173027017849 catalytic Zn binding site [ion binding]; other site 1173027017850 structural Zn binding site [ion binding]; other site 1173027017851 Predicted integral membrane protein [Function unknown]; Region: COG5637 1173027017852 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173027017853 putative hydrophobic ligand binding site [chemical binding]; other site 1173027017854 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1173027017855 classical (c) SDRs; Region: SDR_c; cd05233 1173027017856 NAD(P) binding site [chemical binding]; other site 1173027017857 active site 1173027017858 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173027017859 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1173027017860 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1173027017861 proposed catalytic triad [active] 1173027017862 conserved cys residue [active] 1173027017863 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 1173027017864 Predicted integral membrane protein [Function unknown]; Region: COG5542 1173027017865 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1173027017866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027017867 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027017868 tetramer interface [polypeptide binding]; other site 1173027017869 dimer interface [polypeptide binding]; other site 1173027017870 circadian clock protein KaiC; Reviewed; Region: PRK09302 1173027017871 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027017872 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027017873 Walker A motif; other site 1173027017874 Walker A motif; other site 1173027017875 ATP binding site [chemical binding]; other site 1173027017876 Walker B motif; other site 1173027017877 recA bacterial DNA recombination protein; Region: RecA; cl17211 1173027017878 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173027017879 Walker A motif; other site 1173027017880 ATP binding site [chemical binding]; other site 1173027017881 Walker B motif; other site 1173027017882 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173027017883 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017885 active site 1173027017886 phosphorylation site [posttranslational modification] 1173027017887 intermolecular recognition site; other site 1173027017888 dimerization interface [polypeptide binding]; other site 1173027017889 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027017890 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027017891 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027017892 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027017893 structural tetrad; other site 1173027017894 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027017895 HSP70 interaction site [polypeptide binding]; other site 1173027017896 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173027017897 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027017898 Clp amino terminal domain; Region: Clp_N; pfam02861 1173027017899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027017900 Walker A motif; other site 1173027017901 ATP binding site [chemical binding]; other site 1173027017902 Walker B motif; other site 1173027017903 arginine finger; other site 1173027017904 UvrB/uvrC motif; Region: UVR; pfam02151 1173027017905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027017906 Walker A motif; other site 1173027017907 ATP binding site [chemical binding]; other site 1173027017908 Walker B motif; other site 1173027017909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173027017910 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173027017911 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1173027017912 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1173027017913 active site 1173027017914 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173027017915 substrate binding site [chemical binding]; other site 1173027017916 catalytic residues [active] 1173027017917 dimer interface [polypeptide binding]; other site 1173027017918 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1173027017919 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1173027017920 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1173027017921 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1173027017922 catalytic residue [active] 1173027017923 putative FPP diphosphate binding site; other site 1173027017924 putative FPP binding hydrophobic cleft; other site 1173027017925 dimer interface [polypeptide binding]; other site 1173027017926 putative IPP diphosphate binding site; other site 1173027017927 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 1173027017928 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173027017929 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027017930 HSP70 interaction site [polypeptide binding]; other site 1173027017931 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173027017932 O-Antigen ligase; Region: Wzy_C; pfam04932 1173027017933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1173027017934 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1173027017935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173027017936 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173027017937 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173027017938 active site 1173027017939 NTP binding site [chemical binding]; other site 1173027017940 metal binding triad [ion binding]; metal-binding site 1173027017941 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173027017942 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173027017943 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 1173027017944 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173027017945 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1173027017946 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173027017947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173027017948 S-adenosylmethionine binding site [chemical binding]; other site 1173027017949 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017951 active site 1173027017952 phosphorylation site [posttranslational modification] 1173027017953 intermolecular recognition site; other site 1173027017954 dimerization interface [polypeptide binding]; other site 1173027017955 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027017956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027017957 metal binding site [ion binding]; metal-binding site 1173027017958 active site 1173027017959 I-site; other site 1173027017960 TIGR00701 family protein; Region: TIGR00701 1173027017961 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027017962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027017963 putative binding surface; other site 1173027017964 active site 1173027017965 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027017966 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027017967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027017968 ATP binding site [chemical binding]; other site 1173027017969 Mg2+ binding site [ion binding]; other site 1173027017970 G-X-G motif; other site 1173027017971 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027017972 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017974 active site 1173027017975 phosphorylation site [posttranslational modification] 1173027017976 intermolecular recognition site; other site 1173027017977 dimerization interface [polypeptide binding]; other site 1173027017978 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017979 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017980 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017981 GAF domain; Region: GAF; pfam01590 1173027017982 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017983 GAF domain; Region: GAF; pfam01590 1173027017984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017985 GAF domain; Region: GAF; pfam01590 1173027017986 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027017987 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027017988 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173027017989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027017990 dimer interface [polypeptide binding]; other site 1173027017991 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1173027017992 putative CheW interface [polypeptide binding]; other site 1173027017993 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027017994 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027017995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027017996 active site 1173027017997 phosphorylation site [posttranslational modification] 1173027017998 intermolecular recognition site; other site 1173027017999 dimerization interface [polypeptide binding]; other site 1173027018000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018001 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027018002 active site 1173027018003 phosphorylation site [posttranslational modification] 1173027018004 intermolecular recognition site; other site 1173027018005 dimerization interface [polypeptide binding]; other site 1173027018006 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018007 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018009 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018010 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1173027018011 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1173027018012 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1173027018013 dimerization interface [polypeptide binding]; other site 1173027018014 putative ATP binding site [chemical binding]; other site 1173027018015 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1173027018016 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173027018017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027018018 dimer interface [polypeptide binding]; other site 1173027018019 conserved gate region; other site 1173027018020 ABC-ATPase subunit interface; other site 1173027018021 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1173027018022 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173027018023 CHAT domain; Region: CHAT; cl17868 1173027018024 TPR repeat; Region: TPR_11; pfam13414 1173027018025 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173027018026 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 1173027018027 putative ligand binding site [chemical binding]; other site 1173027018028 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027018029 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018030 active site 1173027018031 ATP binding site [chemical binding]; other site 1173027018032 substrate binding site [chemical binding]; other site 1173027018033 activation loop (A-loop); other site 1173027018034 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027018035 TPR repeat; Region: TPR_11; pfam13414 1173027018036 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173027018037 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 1173027018038 putative ligand binding site [chemical binding]; other site 1173027018039 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1173027018040 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173027018041 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027018042 putative ADP-binding pocket [chemical binding]; other site 1173027018043 Predicted permeases [General function prediction only]; Region: COG0679 1173027018044 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173027018045 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173027018046 putative dimer interface [polypeptide binding]; other site 1173027018047 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018048 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018049 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027018050 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018051 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018052 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018053 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018054 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018055 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173027018056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018057 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018059 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018060 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018061 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1173027018062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173027018063 active site 1173027018064 metal binding site [ion binding]; metal-binding site 1173027018065 hexamer interface [polypeptide binding]; other site 1173027018066 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1173027018067 Divergent AAA domain; Region: AAA_4; pfam04326 1173027018068 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1173027018069 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1173027018070 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1173027018071 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027018072 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027018073 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1173027018074 TniQ; Region: TniQ; pfam06527 1173027018075 AAA domain; Region: AAA_22; pfam13401 1173027018076 Integrase core domain; Region: rve; pfam00665 1173027018077 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027018078 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1173027018079 active site 1173027018080 substrate binding pocket [chemical binding]; other site 1173027018081 dimer interface [polypeptide binding]; other site 1173027018082 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018083 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018084 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018085 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018087 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173027018088 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027018089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027018090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018091 active site 1173027018092 phosphorylation site [posttranslational modification] 1173027018093 intermolecular recognition site; other site 1173027018094 dimerization interface [polypeptide binding]; other site 1173027018095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027018096 DNA binding residues [nucleotide binding] 1173027018097 dimerization interface [polypeptide binding]; other site 1173027018098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027018099 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027018100 putative switch regulator; other site 1173027018101 non-specific DNA interactions [nucleotide binding]; other site 1173027018102 DNA binding site [nucleotide binding] 1173027018103 sequence specific DNA binding site [nucleotide binding]; other site 1173027018104 putative cAMP binding site [chemical binding]; other site 1173027018105 GUN4-like; Region: GUN4; pfam05419 1173027018106 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173027018107 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173027018108 putative ADP-binding pocket [chemical binding]; other site 1173027018109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027018110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027018111 dimer interface [polypeptide binding]; other site 1173027018112 phosphorylation site [posttranslational modification] 1173027018113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018114 ATP binding site [chemical binding]; other site 1173027018115 Mg2+ binding site [ion binding]; other site 1173027018116 G-X-G motif; other site 1173027018117 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1173027018118 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1173027018119 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027018120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173027018121 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 1173027018122 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027018123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018124 active site 1173027018125 phosphorylation site [posttranslational modification] 1173027018126 intermolecular recognition site; other site 1173027018127 dimerization interface [polypeptide binding]; other site 1173027018128 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027018129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018130 binding surface 1173027018131 TPR motif; other site 1173027018132 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1173027018133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027018134 dimerization interface [polypeptide binding]; other site 1173027018135 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027018136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027018137 dimer interface [polypeptide binding]; other site 1173027018138 phosphorylation site [posttranslational modification] 1173027018139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018140 ATP binding site [chemical binding]; other site 1173027018141 Mg2+ binding site [ion binding]; other site 1173027018142 G-X-G motif; other site 1173027018143 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1173027018144 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1173027018145 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1173027018146 Ligand Binding Site [chemical binding]; other site 1173027018147 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1173027018148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027018149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018150 active site 1173027018151 ATP binding site [chemical binding]; other site 1173027018152 substrate binding site [chemical binding]; other site 1173027018153 activation loop (A-loop); other site 1173027018154 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1173027018155 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1173027018156 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1173027018157 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1173027018158 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1173027018159 ligand binding site [chemical binding]; other site 1173027018160 homodimer interface [polypeptide binding]; other site 1173027018161 NAD(P) binding site [chemical binding]; other site 1173027018162 trimer interface B [polypeptide binding]; other site 1173027018163 trimer interface A [polypeptide binding]; other site 1173027018164 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173027018165 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1173027018166 Ribonuclease P; Region: Ribonuclease_P; cl00457 1173027018167 Bacterial PH domain; Region: DUF304; pfam03703 1173027018168 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 1173027018169 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1173027018170 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1173027018171 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1173027018172 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1173027018173 G-X-X-G motif; other site 1173027018174 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1173027018175 RxxxH motif; other site 1173027018176 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1173027018177 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173027018178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173027018179 Probable transposase; Region: OrfB_IS605; pfam01385 1173027018180 Ycf46; Provisional; Region: ycf46; CHL00195 1173027018181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027018182 Walker A motif; other site 1173027018183 ATP binding site [chemical binding]; other site 1173027018184 Walker B motif; other site 1173027018185 arginine finger; other site 1173027018186 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027018187 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1173027018188 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173027018189 active site 1173027018190 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173027018191 active site 1173027018192 catalytic triad [active] 1173027018193 oxyanion hole [active] 1173027018194 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1173027018195 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1173027018196 Active site cavity [active] 1173027018197 catalytic acid [active] 1173027018198 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1173027018199 substrate binding pocket [chemical binding]; other site 1173027018200 substrate-Mg2+ binding site; other site 1173027018201 aspartate-rich region 1; other site 1173027018202 aspartate-rich region 2; other site 1173027018203 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1173027018204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027018205 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173027018206 Walker A/P-loop; other site 1173027018207 ATP binding site [chemical binding]; other site 1173027018208 Q-loop/lid; other site 1173027018209 ABC transporter signature motif; other site 1173027018210 Walker B; other site 1173027018211 D-loop; other site 1173027018212 H-loop/switch region; other site 1173027018213 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027018214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027018215 active site 1173027018216 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018217 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027018218 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173027018219 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173027018220 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027018221 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1173027018222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018223 TPR motif; other site 1173027018224 binding surface 1173027018225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027018227 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1173027018228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173027018229 S-adenosylmethionine binding site [chemical binding]; other site 1173027018230 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1173027018231 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1173027018232 BRO family, N-terminal domain; Region: Bro-N; smart01040 1173027018233 Caspase domain; Region: Peptidase_C14; pfam00656 1173027018234 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1173027018235 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1173027018236 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1173027018237 ligand binding site; other site 1173027018238 B12 binding domain; Region: B12-binding; pfam02310 1173027018239 B12 binding site [chemical binding]; other site 1173027018240 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1173027018241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027018242 FeS/SAM binding site; other site 1173027018243 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173027018244 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1173027018245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027018246 FeS/SAM binding site; other site 1173027018247 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1173027018248 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018249 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027018250 CHAT domain; Region: CHAT; pfam12770 1173027018251 PAAR motif; Region: PAAR_motif; pfam05488 1173027018252 Phage protein D [General function prediction only]; Region: COG3500 1173027018253 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1173027018254 large tegument protein UL36; Provisional; Region: PHA03247 1173027018255 DNA translocase FtsK; Provisional; Region: PRK10263 1173027018256 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 1173027018257 Protein kinase domain; Region: Pkinase; pfam00069 1173027018258 PBP superfamily domain; Region: PBP_like_2; cl17296 1173027018259 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1173027018260 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1173027018261 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1173027018262 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173027018263 argininosuccinate synthase; Provisional; Region: PRK13820 1173027018264 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1173027018265 Ligand Binding Site [chemical binding]; other site 1173027018266 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1173027018267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027018268 Walker A motif; other site 1173027018269 ATP binding site [chemical binding]; other site 1173027018270 Walker B motif; other site 1173027018271 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1173027018272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027018273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018274 active site 1173027018275 phosphorylation site [posttranslational modification] 1173027018276 intermolecular recognition site; other site 1173027018277 dimerization interface [polypeptide binding]; other site 1173027018278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027018279 DNA binding residues [nucleotide binding] 1173027018280 dimerization interface [polypeptide binding]; other site 1173027018281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027018282 dimer interface [polypeptide binding]; other site 1173027018283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1173027018284 phosphorylation site [posttranslational modification] 1173027018285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018286 ATP binding site [chemical binding]; other site 1173027018287 Mg2+ binding site [ion binding]; other site 1173027018288 G-X-G motif; other site 1173027018289 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1173027018290 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1173027018291 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1173027018292 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1173027018293 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1173027018294 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1173027018295 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1173027018296 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027018297 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027018298 CHASE2 domain; Region: CHASE2; pfam05226 1173027018299 Cupin domain; Region: Cupin_2; pfam07883 1173027018300 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1173027018301 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1173027018302 phage tail protein domain; Region: tail_TIGR02242 1173027018303 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1173027018304 HAMP domain; Region: HAMP; pfam00672 1173027018305 dimerization interface [polypeptide binding]; other site 1173027018306 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018307 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027018308 structural tetrad; other site 1173027018309 CARDB; Region: CARDB; pfam07705 1173027018310 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027018311 putative active site [active] 1173027018312 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1173027018313 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1173027018314 nucleotide binding site/active site [active] 1173027018315 HIT family signature motif; other site 1173027018316 catalytic residue [active] 1173027018317 Predicted metalloprotease [General function prediction only]; Region: COG2321 1173027018318 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1173027018319 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173027018320 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1173027018321 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173027018322 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173027018323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027018324 motif II; other site 1173027018325 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173027018326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173027018327 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1173027018328 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173027018329 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173027018330 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1173027018331 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173027018332 active site 1173027018333 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 1173027018334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027018335 non-specific DNA binding site [nucleotide binding]; other site 1173027018336 salt bridge; other site 1173027018337 sequence-specific DNA binding site [nucleotide binding]; other site 1173027018338 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173027018339 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173027018340 Glucose inhibited division protein A; Region: GIDA; pfam01134 1173027018341 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173027018342 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027018343 phosphopeptide binding site; other site 1173027018344 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173027018345 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173027018346 active site 1173027018347 putative substrate binding region [chemical binding]; other site 1173027018348 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1173027018349 carboxyl-terminal processing protease; Provisional; Region: PLN00049 1173027018350 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173027018351 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173027018352 protein binding site [polypeptide binding]; other site 1173027018353 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173027018354 Catalytic dyad [active] 1173027018355 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173027018356 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1173027018357 Qi binding site; other site 1173027018358 intrachain domain interface; other site 1173027018359 interchain domain interface [polypeptide binding]; other site 1173027018360 heme bH binding site [chemical binding]; other site 1173027018361 heme bL binding site [chemical binding]; other site 1173027018362 Qo binding site; other site 1173027018363 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173027018364 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1173027018365 interchain domain interface [polypeptide binding]; other site 1173027018366 intrachain domain interface; other site 1173027018367 Qi binding site; other site 1173027018368 Qo binding site; other site 1173027018369 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027018370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027018371 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 1173027018372 RDD family; Region: RDD; pfam06271 1173027018373 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018374 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027018375 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018376 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018380 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1173027018382 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173027018383 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173027018384 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1173027018385 Leucine rich repeat; Region: LRR_8; pfam13855 1173027018386 Substrate binding site [chemical binding]; other site 1173027018387 Leucine rich repeat; Region: LRR_8; pfam13855 1173027018388 Protein kinase; unclassified specificity; Region: STYKc; smart00221 1173027018389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173027018390 active site 1173027018391 ATP binding site [chemical binding]; other site 1173027018392 substrate binding site [chemical binding]; other site 1173027018393 activation loop (A-loop); other site 1173027018394 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027018395 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027018396 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1173027018397 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1173027018398 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1173027018399 trimer interface [polypeptide binding]; other site 1173027018400 active site 1173027018401 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1173027018402 catalytic site [active] 1173027018403 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173027018404 protein I interface; other site 1173027018405 D2 interface; other site 1173027018406 protein T interface; other site 1173027018407 chlorophyll binding site; other site 1173027018408 beta carotene binding site; other site 1173027018409 pheophytin binding site; other site 1173027018410 manganese-stabilizing polypeptide interface; other site 1173027018411 CP43 interface; other site 1173027018412 protein L interface; other site 1173027018413 oxygen evolving complex binding site; other site 1173027018414 bromide binding site; other site 1173027018415 quinone binding site; other site 1173027018416 Fe binding site [ion binding]; other site 1173027018417 core light harvesting interface; other site 1173027018418 cytochrome b559 alpha subunit interface; other site 1173027018419 cytochrome c-550 interface; other site 1173027018420 protein J interface; other site 1173027018421 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 1173027018422 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1173027018423 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1173027018424 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1173027018425 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1173027018426 cytosine deaminase; Provisional; Region: PRK09230 1173027018427 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1173027018428 active site 1173027018429 Herpesvirus alkaline exonuclease; Region: Herpes_alk_exo; pfam01771 1173027018430 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173027018431 Cytochrome P450; Region: p450; pfam00067 1173027018432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173027018433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027018434 Coenzyme A binding pocket [chemical binding]; other site 1173027018435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173027018436 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1173027018437 substrate binding site [chemical binding]; other site 1173027018438 dimer interface [polypeptide binding]; other site 1173027018439 ATP binding site [chemical binding]; other site 1173027018440 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173027018441 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173027018442 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1173027018443 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1173027018444 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173027018445 DRTGG domain; Region: DRTGG; pfam07085 1173027018446 YjcZ-like protein; Region: YjcZ; pfam13990 1173027018447 2-isopropylmalate synthase; Validated; Region: PRK00915 1173027018448 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173027018449 active site 1173027018450 catalytic residues [active] 1173027018451 metal binding site [ion binding]; metal-binding site 1173027018452 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1173027018453 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1173027018454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173027018455 DNA-binding site [nucleotide binding]; DNA binding site 1173027018456 FCD domain; Region: FCD; pfam07729 1173027018457 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 1173027018458 oligomer interface [polypeptide binding]; other site 1173027018459 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173027018460 peripheral dimer interface [polypeptide binding]; other site 1173027018461 core dimer interface [polypeptide binding]; other site 1173027018462 L10 interface [polypeptide binding]; other site 1173027018463 L11 interface [polypeptide binding]; other site 1173027018464 putative EF-Tu interaction site [polypeptide binding]; other site 1173027018465 putative EF-G interaction site [polypeptide binding]; other site 1173027018466 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027018467 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027018468 cofactor binding site; other site 1173027018469 DNA binding site [nucleotide binding] 1173027018470 substrate interaction site [chemical binding]; other site 1173027018471 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 1173027018472 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173027018473 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1173027018474 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027018475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027018476 Walker A/P-loop; other site 1173027018477 ATP binding site [chemical binding]; other site 1173027018478 Q-loop/lid; other site 1173027018479 ABC transporter signature motif; other site 1173027018480 Walker B; other site 1173027018481 D-loop; other site 1173027018482 H-loop/switch region; other site 1173027018483 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1173027018484 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1173027018485 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1173027018486 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1173027018487 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1173027018488 putative NADP binding site [chemical binding]; other site 1173027018489 putative substrate binding site [chemical binding]; other site 1173027018490 active site 1173027018491 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1173027018492 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1173027018493 active site 1173027018494 metal binding site [ion binding]; metal-binding site 1173027018495 DNA binding site [nucleotide binding] 1173027018496 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173027018497 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173027018498 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173027018499 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173027018500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173027018501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027018502 Walker A/P-loop; other site 1173027018503 ATP binding site [chemical binding]; other site 1173027018504 Q-loop/lid; other site 1173027018505 ABC transporter signature motif; other site 1173027018506 Walker B; other site 1173027018507 D-loop; other site 1173027018508 H-loop/switch region; other site 1173027018509 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173027018510 active site 1173027018511 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173027018512 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173027018513 iron-sulfur cluster [ion binding]; other site 1173027018514 [2Fe-2S] cluster binding site [ion binding]; other site 1173027018515 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027018516 CHASE2 domain; Region: CHASE2; pfam05226 1173027018517 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027018518 cyclase homology domain; Region: CHD; cd07302 1173027018519 nucleotidyl binding site; other site 1173027018520 metal binding site [ion binding]; metal-binding site 1173027018521 dimer interface [polypeptide binding]; other site 1173027018522 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027018523 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018524 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027018525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027018526 binding surface 1173027018527 TPR motif; other site 1173027018528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018530 binding surface 1173027018531 TPR motif; other site 1173027018532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018534 binding surface 1173027018535 TPR motif; other site 1173027018536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027018537 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027018538 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027018539 P-loop; other site 1173027018540 Magnesium ion binding site [ion binding]; other site 1173027018541 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 1173027018542 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173027018543 PYR/PP interface [polypeptide binding]; other site 1173027018544 dimer interface [polypeptide binding]; other site 1173027018545 TPP binding site [chemical binding]; other site 1173027018546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173027018547 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1173027018548 TPP-binding site [chemical binding]; other site 1173027018549 dimer interface [polypeptide binding]; other site 1173027018550 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173027018551 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173027018552 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173027018553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027018554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027018555 dimer interface [polypeptide binding]; other site 1173027018556 phosphorylation site [posttranslational modification] 1173027018557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018558 ATP binding site [chemical binding]; other site 1173027018559 Mg2+ binding site [ion binding]; other site 1173027018560 G-X-G motif; other site 1173027018561 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027018562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018563 active site 1173027018564 phosphorylation site [posttranslational modification] 1173027018565 intermolecular recognition site; other site 1173027018566 dimerization interface [polypeptide binding]; other site 1173027018567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027018568 DNA binding residues [nucleotide binding] 1173027018569 dimerization interface [polypeptide binding]; other site 1173027018570 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1173027018571 Aspartase; Region: Aspartase; cd01357 1173027018572 active sites [active] 1173027018573 tetramer interface [polypeptide binding]; other site 1173027018574 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173027018575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027018576 Walker A/P-loop; other site 1173027018577 ATP binding site [chemical binding]; other site 1173027018578 Q-loop/lid; other site 1173027018579 ABC transporter signature motif; other site 1173027018580 Walker B; other site 1173027018581 D-loop; other site 1173027018582 H-loop/switch region; other site 1173027018583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1173027018584 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173027018585 Walker A/P-loop; other site 1173027018586 ATP binding site [chemical binding]; other site 1173027018587 Q-loop/lid; other site 1173027018588 ABC transporter signature motif; other site 1173027018589 Walker B; other site 1173027018590 D-loop; other site 1173027018591 H-loop/switch region; other site 1173027018592 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173027018593 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173027018594 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1173027018595 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027018596 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173027018597 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173027018598 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173027018599 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173027018600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018601 binding surface 1173027018602 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173027018603 TPR motif; other site 1173027018604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018606 binding surface 1173027018607 TPR motif; other site 1173027018608 TPR repeat; Region: TPR_11; pfam13414 1173027018609 Domain of unknown function DUF39; Region: DUF39; pfam01837 1173027018610 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173027018611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027018612 Walker A/P-loop; other site 1173027018613 ATP binding site [chemical binding]; other site 1173027018614 Q-loop/lid; other site 1173027018615 ABC transporter signature motif; other site 1173027018616 Walker B; other site 1173027018617 D-loop; other site 1173027018618 H-loop/switch region; other site 1173027018619 TOBE domain; Region: TOBE_2; pfam08402 1173027018620 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173027018621 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173027018622 dimerization interface [polypeptide binding]; other site 1173027018623 DPS ferroxidase diiron center [ion binding]; other site 1173027018624 ion pore; other site 1173027018625 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027018626 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027018627 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027018628 HEAT repeats; Region: HEAT_2; pfam13646 1173027018629 HEAT repeats; Region: HEAT_2; pfam13646 1173027018630 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027018631 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173027018632 HEAT repeats; Region: HEAT_2; pfam13646 1173027018633 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173027018634 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173027018635 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173027018636 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 1173027018637 Ion channel; Region: Ion_trans_2; pfam07885 1173027018638 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173027018639 TrkA-N domain; Region: TrkA_N; pfam02254 1173027018640 TrkA-C domain; Region: TrkA_C; pfam02080 1173027018641 acetylornithine aminotransferase; Provisional; Region: PRK02627 1173027018642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173027018643 inhibitor-cofactor binding pocket; inhibition site 1173027018644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027018645 catalytic residue [active] 1173027018646 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027018647 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173027018648 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1173027018649 active site 1173027018650 putative DNA-binding cleft [nucleotide binding]; other site 1173027018651 dimer interface [polypeptide binding]; other site 1173027018652 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1173027018653 phosphate binding site [ion binding]; other site 1173027018654 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1173027018655 putative substrate binding pocket [chemical binding]; other site 1173027018656 dimer interface [polypeptide binding]; other site 1173027018657 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1173027018658 Protein kinase domain; Region: Pkinase; pfam00069 1173027018659 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018660 active site 1173027018661 ATP binding site [chemical binding]; other site 1173027018662 substrate binding site [chemical binding]; other site 1173027018663 activation loop (A-loop); other site 1173027018664 prefoldin subunit beta; Provisional; Region: PRK09343 1173027018665 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1173027018666 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1173027018667 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1173027018668 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027018669 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018671 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018672 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018673 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1173027018674 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1173027018675 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1173027018676 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173027018677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173027018678 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173027018679 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027018680 putative active site [active] 1173027018681 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173027018682 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027018683 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018684 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1173027018685 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1173027018686 putative active site [active] 1173027018687 putative metal binding site [ion binding]; other site 1173027018688 cell division protein; Validated; Region: ftsH; CHL00176 1173027018689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027018690 Walker A motif; other site 1173027018691 ATP binding site [chemical binding]; other site 1173027018692 Walker B motif; other site 1173027018693 arginine finger; other site 1173027018694 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173027018695 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173027018696 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1173027018697 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1173027018698 dimerization interface [polypeptide binding]; other site 1173027018699 FAD binding pocket [chemical binding]; other site 1173027018700 FAD binding motif [chemical binding]; other site 1173027018701 catalytic residues [active] 1173027018702 NAD binding pocket [chemical binding]; other site 1173027018703 phosphate binding motif [ion binding]; other site 1173027018704 beta-alpha-beta structure motif; other site 1173027018705 phosphoribulokinase; Provisional; Region: PRK07429 1173027018706 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173027018707 active site 1173027018708 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027018709 CHASE2 domain; Region: CHASE2; pfam05226 1173027018710 PAS fold; Region: PAS_4; pfam08448 1173027018711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027018712 putative active site [active] 1173027018713 heme pocket [chemical binding]; other site 1173027018714 PAS domain S-box; Region: sensory_box; TIGR00229 1173027018715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027018716 putative active site [active] 1173027018717 heme pocket [chemical binding]; other site 1173027018718 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027018719 cyclase homology domain; Region: CHD; cd07302 1173027018720 nucleotidyl binding site; other site 1173027018721 metal binding site [ion binding]; metal-binding site 1173027018722 dimer interface [polypeptide binding]; other site 1173027018723 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027018724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027018725 TPR motif; other site 1173027018726 binding surface 1173027018727 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018728 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027018730 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018731 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027018732 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027018733 CHASE2 domain; Region: CHASE2; pfam05226 1173027018734 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1173027018735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027018736 PAS domain; Region: PAS_9; pfam13426 1173027018737 putative active site [active] 1173027018738 heme pocket [chemical binding]; other site 1173027018739 PAS domain S-box; Region: sensory_box; TIGR00229 1173027018740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027018741 putative active site [active] 1173027018742 heme pocket [chemical binding]; other site 1173027018743 cyclase homology domain; Region: CHD; cd07302 1173027018744 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173027018745 nucleotidyl binding site; other site 1173027018746 metal binding site [ion binding]; metal-binding site 1173027018747 dimer interface [polypeptide binding]; other site 1173027018748 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173027018749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027018750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027018751 binding surface 1173027018752 TPR motif; other site 1173027018753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027018754 Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494 1173027018755 active site 1173027018756 catalytic triad [active] 1173027018757 AAA ATPase domain; Region: AAA_16; pfam13191 1173027018758 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027018759 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018760 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027018761 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018762 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027018763 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027018764 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1173027018765 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1173027018766 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173027018767 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1173027018768 YcxB-like protein; Region: YcxB; pfam14317 1173027018769 photosystem II 47 kDa protein; Region: psbB; CHL00062 1173027018770 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 1173027018771 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1173027018772 ATP cone domain; Region: ATP-cone; pfam03477 1173027018773 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173027018774 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173027018775 RNA binding site [nucleotide binding]; other site 1173027018776 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173027018777 RNA binding site [nucleotide binding]; other site 1173027018778 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1173027018779 RNA binding site [nucleotide binding]; other site 1173027018780 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173027018781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027018782 motif II; other site 1173027018783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173027018784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173027018785 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173027018786 Walker A/P-loop; other site 1173027018787 ATP binding site [chemical binding]; other site 1173027018788 Q-loop/lid; other site 1173027018789 ABC transporter signature motif; other site 1173027018790 Walker B; other site 1173027018791 D-loop; other site 1173027018792 H-loop/switch region; other site 1173027018793 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1173027018794 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1173027018795 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1173027018796 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1173027018797 replicative DNA helicase; Region: DnaB; TIGR00665 1173027018798 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173027018799 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1173027018800 Walker A motif; other site 1173027018801 ATP binding site [chemical binding]; other site 1173027018802 Walker B motif; other site 1173027018803 DNA binding loops [nucleotide binding] 1173027018804 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1173027018805 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173027018806 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173027018807 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 1173027018808 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173027018809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173027018810 dimerization interface [polypeptide binding]; other site 1173027018811 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173027018812 PAS domain; Region: PAS; smart00091 1173027018813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027018814 dimer interface [polypeptide binding]; other site 1173027018815 phosphorylation site [posttranslational modification] 1173027018816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018817 ATP binding site [chemical binding]; other site 1173027018818 Mg2+ binding site [ion binding]; other site 1173027018819 G-X-G motif; other site 1173027018820 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1173027018821 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1173027018822 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1173027018823 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1173027018824 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 1173027018825 DNA photolyase; Region: DNA_photolyase; pfam00875 1173027018826 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1173027018827 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1173027018828 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173027018829 dimer interface [polypeptide binding]; other site 1173027018830 ADP-ribose binding site [chemical binding]; other site 1173027018831 active site 1173027018832 nudix motif; other site 1173027018833 metal binding site [ion binding]; metal-binding site 1173027018834 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1173027018835 catalytic center binding site [active] 1173027018836 ATP binding site [chemical binding]; other site 1173027018837 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173027018838 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018839 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018840 structural tetrad; other site 1173027018841 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027018842 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018843 active site 1173027018844 ATP binding site [chemical binding]; other site 1173027018845 substrate binding site [chemical binding]; other site 1173027018846 activation loop (A-loop); other site 1173027018847 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018848 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018849 structural tetrad; other site 1173027018850 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027018851 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018852 active site 1173027018853 ATP binding site [chemical binding]; other site 1173027018854 substrate binding site [chemical binding]; other site 1173027018855 activation loop (A-loop); other site 1173027018856 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018857 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018858 structural tetrad; other site 1173027018859 PQQ-like domain; Region: PQQ_2; pfam13360 1173027018860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027018861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027018862 active site 1173027018863 ATP binding site [chemical binding]; other site 1173027018864 substrate binding site [chemical binding]; other site 1173027018865 activation loop (A-loop); other site 1173027018866 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018867 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018868 structural tetrad; other site 1173027018869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027018870 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173027018871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027018872 catalytic residue [active] 1173027018873 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1173027018874 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1173027018875 homodimer interface [polypeptide binding]; other site 1173027018876 oligonucleotide binding site [chemical binding]; other site 1173027018877 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1173027018878 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173027018879 active site 1173027018880 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173027018881 prephenate dehydratase; Provisional; Region: PRK11898 1173027018882 Prephenate dehydratase; Region: PDT; pfam00800 1173027018883 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1173027018884 putative L-Phe binding site [chemical binding]; other site 1173027018885 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1173027018886 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1173027018887 elongation factor Tu; Region: tufA; CHL00071 1173027018888 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1173027018889 G1 box; other site 1173027018890 GEF interaction site [polypeptide binding]; other site 1173027018891 GTP/Mg2+ binding site [chemical binding]; other site 1173027018892 Switch I region; other site 1173027018893 G2 box; other site 1173027018894 G3 box; other site 1173027018895 Switch II region; other site 1173027018896 G4 box; other site 1173027018897 G5 box; other site 1173027018898 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1173027018899 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1173027018900 Antibiotic Binding Site [chemical binding]; other site 1173027018901 elongation factor G; Reviewed; Region: PRK00007 1173027018902 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1173027018903 G1 box; other site 1173027018904 putative GEF interaction site [polypeptide binding]; other site 1173027018905 GTP/Mg2+ binding site [chemical binding]; other site 1173027018906 Switch I region; other site 1173027018907 G2 box; other site 1173027018908 G3 box; other site 1173027018909 Switch II region; other site 1173027018910 G4 box; other site 1173027018911 G5 box; other site 1173027018912 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173027018913 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173027018914 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173027018915 30S ribosomal protein S7; Validated; Region: PRK05302 1173027018916 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1173027018917 S17 interaction site [polypeptide binding]; other site 1173027018918 S8 interaction site; other site 1173027018919 16S rRNA interaction site [nucleotide binding]; other site 1173027018920 streptomycin interaction site [chemical binding]; other site 1173027018921 23S rRNA interaction site [nucleotide binding]; other site 1173027018922 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1173027018923 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1173027018924 Cupin domain; Region: Cupin_2; cl17218 1173027018925 AMIN domain; Region: AMIN; pfam11741 1173027018926 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173027018927 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173027018928 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173027018929 active site 1173027018930 dimer interface [polypeptide binding]; other site 1173027018931 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173027018932 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173027018933 active site 1173027018934 FMN binding site [chemical binding]; other site 1173027018935 substrate binding site [chemical binding]; other site 1173027018936 3Fe-4S cluster binding site [ion binding]; other site 1173027018937 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173027018938 domain interface; other site 1173027018939 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173027018940 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173027018941 NodB motif; other site 1173027018942 active site 1173027018943 catalytic site [active] 1173027018944 metal binding site [ion binding]; metal-binding site 1173027018945 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027018946 Chain length determinant protein; Region: Wzz; cl15801 1173027018947 FlxA-like protein; Region: FlxA; pfam14282 1173027018948 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027018949 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027018950 Magnesium ion binding site [ion binding]; other site 1173027018951 K+ potassium transporter; Region: K_trans; cl15781 1173027018952 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1173027018953 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1173027018954 TPP-binding site; other site 1173027018955 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173027018956 PYR/PP interface [polypeptide binding]; other site 1173027018957 dimer interface [polypeptide binding]; other site 1173027018958 TPP binding site [chemical binding]; other site 1173027018959 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173027018960 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1173027018961 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1173027018962 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027018963 putative active site [active] 1173027018964 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 1173027018965 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173027018966 TIR domain; Region: TIR_2; pfam13676 1173027018967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027018968 TIR domain; Region: TIR_2; pfam13676 1173027018969 TIR domain; Region: TIR_2; pfam13676 1173027018970 TIR domain; Region: TIR_2; pfam13676 1173027018971 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018972 structural tetrad; other site 1173027018973 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027018974 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018975 structural tetrad; other site 1173027018976 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027018977 structural tetrad; other site 1173027018978 hypothetical protein; Validated; Region: PRK00110 1173027018979 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027018980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018981 active site 1173027018982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027018983 phosphorylation site [posttranslational modification] 1173027018984 intermolecular recognition site; other site 1173027018985 dimerization interface [polypeptide binding]; other site 1173027018986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027018987 phosphorylation site [posttranslational modification] 1173027018988 dimer interface [polypeptide binding]; other site 1173027018989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027018990 ATP binding site [chemical binding]; other site 1173027018991 Mg2+ binding site [ion binding]; other site 1173027018992 G-X-G motif; other site 1173027018993 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027018994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027018995 active site 1173027018996 phosphorylation site [posttranslational modification] 1173027018997 intermolecular recognition site; other site 1173027018998 dimerization interface [polypeptide binding]; other site 1173027018999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173027019000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173027019001 metal binding site [ion binding]; metal-binding site 1173027019002 active site 1173027019003 I-site; other site 1173027019004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173027019005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027019006 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027019007 PAS fold; Region: PAS_4; pfam08448 1173027019008 PAS domain S-box; Region: sensory_box; TIGR00229 1173027019009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027019010 putative active site [active] 1173027019011 heme pocket [chemical binding]; other site 1173027019012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027019013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027019014 dimer interface [polypeptide binding]; other site 1173027019015 phosphorylation site [posttranslational modification] 1173027019016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019017 ATP binding site [chemical binding]; other site 1173027019018 Mg2+ binding site [ion binding]; other site 1173027019019 G-X-G motif; other site 1173027019020 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027019021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019022 active site 1173027019023 phosphorylation site [posttranslational modification] 1173027019024 intermolecular recognition site; other site 1173027019025 dimerization interface [polypeptide binding]; other site 1173027019026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173027019027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173027019028 glucokinase; Provisional; Region: glk; PRK00292 1173027019029 glucokinase, proteobacterial type; Region: glk; TIGR00749 1173027019030 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173027019031 catalytic core [active] 1173027019032 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 1173027019033 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173027019034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173027019035 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173027019036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173027019037 DNA binding residues [nucleotide binding] 1173027019038 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173027019039 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1173027019040 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173027019041 minor groove reading motif; other site 1173027019042 helix-hairpin-helix signature motif; other site 1173027019043 substrate binding pocket [chemical binding]; other site 1173027019044 active site 1173027019045 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1173027019046 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1173027019047 active site 1173027019048 8-oxo-dGMP binding site [chemical binding]; other site 1173027019049 nudix motif; other site 1173027019050 metal binding site [ion binding]; metal-binding site 1173027019051 adaptive-response sensory kinase; Validated; Region: PRK09303 1173027019052 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173027019053 tetramer interface [polypeptide binding]; other site 1173027019054 dimer interface [polypeptide binding]; other site 1173027019055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027019056 dimer interface [polypeptide binding]; other site 1173027019057 phosphorylation site [posttranslational modification] 1173027019058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019059 ATP binding site [chemical binding]; other site 1173027019060 Mg2+ binding site [ion binding]; other site 1173027019061 G-X-G motif; other site 1173027019062 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1173027019063 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1173027019064 active site 1173027019065 substrate binding site [chemical binding]; other site 1173027019066 catalytic site [active] 1173027019067 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1173027019068 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019069 putative active site [active] 1173027019070 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027019071 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027019072 structural tetrad; other site 1173027019073 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173027019074 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019075 putative active site [active] 1173027019076 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019077 putative active site [active] 1173027019078 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173027019079 putative active site pocket [active] 1173027019080 dimerization interface [polypeptide binding]; other site 1173027019081 putative catalytic residue [active] 1173027019082 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173027019083 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173027019084 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027019085 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027019086 P-loop; other site 1173027019087 Magnesium ion binding site [ion binding]; other site 1173027019088 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1173027019089 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1173027019090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173027019091 dimer interface [polypeptide binding]; other site 1173027019092 conserved gate region; other site 1173027019093 ABC-ATPase subunit interface; other site 1173027019094 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1173027019095 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1173027019096 Walker A/P-loop; other site 1173027019097 ATP binding site [chemical binding]; other site 1173027019098 Q-loop/lid; other site 1173027019099 ABC transporter signature motif; other site 1173027019100 Walker B; other site 1173027019101 D-loop; other site 1173027019102 H-loop/switch region; other site 1173027019103 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1173027019104 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173027019105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027019106 Coenzyme A binding pocket [chemical binding]; other site 1173027019107 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1173027019108 biotin synthase; Region: bioB; TIGR00433 1173027019109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173027019110 FeS/SAM binding site; other site 1173027019111 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1173027019112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027019113 PAS fold; Region: PAS_3; pfam08447 1173027019114 putative active site [active] 1173027019115 heme pocket [chemical binding]; other site 1173027019116 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027019117 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027019118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173027019119 PAS domain; Region: PAS_9; pfam13426 1173027019120 putative active site [active] 1173027019121 heme pocket [chemical binding]; other site 1173027019122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027019123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027019124 dimer interface [polypeptide binding]; other site 1173027019125 phosphorylation site [posttranslational modification] 1173027019126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019127 ATP binding site [chemical binding]; other site 1173027019128 Mg2+ binding site [ion binding]; other site 1173027019129 G-X-G motif; other site 1173027019130 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173027019131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173027019132 metal-binding site [ion binding] 1173027019133 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173027019134 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173027019135 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 1173027019136 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173027019137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173027019138 Histidine kinase; Region: HisKA_3; pfam07730 1173027019139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019140 ATP binding site [chemical binding]; other site 1173027019141 Mg2+ binding site [ion binding]; other site 1173027019142 G-X-G motif; other site 1173027019143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173027019144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019145 active site 1173027019146 phosphorylation site [posttranslational modification] 1173027019147 intermolecular recognition site; other site 1173027019148 dimerization interface [polypeptide binding]; other site 1173027019149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173027019150 DNA binding residues [nucleotide binding] 1173027019151 dimerization interface [polypeptide binding]; other site 1173027019152 50S ribosomal protein L37Ae; Reviewed; Region: rpl37ae; PRK03976 1173027019153 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027019154 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019156 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019157 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019158 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019159 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019160 Uncharacterized conserved protein [Function unknown]; Region: COG5607 1173027019161 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173027019162 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173027019163 putative switch regulator; other site 1173027019164 non-specific DNA interactions [nucleotide binding]; other site 1173027019165 DNA binding site [nucleotide binding] 1173027019166 sequence specific DNA binding site [nucleotide binding]; other site 1173027019167 putative cAMP binding site [chemical binding]; other site 1173027019168 putative hydrolase; Provisional; Region: PRK11460 1173027019169 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173027019170 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 1173027019171 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1173027019172 Flavoprotein; Region: Flavoprotein; pfam02441 1173027019173 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1173027019174 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 1173027019175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019176 ATP binding site [chemical binding]; other site 1173027019177 putative Mg++ binding site [ion binding]; other site 1173027019178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027019179 nucleotide binding region [chemical binding]; other site 1173027019180 ATP-binding site [chemical binding]; other site 1173027019181 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173027019182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027019183 Walker A/P-loop; other site 1173027019184 ATP binding site [chemical binding]; other site 1173027019185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019186 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027019187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019189 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173027019190 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173027019191 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019192 putative active site [active] 1173027019193 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1173027019194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173027019195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027019196 homodimer interface [polypeptide binding]; other site 1173027019197 catalytic residue [active] 1173027019198 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173027019199 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1173027019200 putative active site [active] 1173027019201 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1173027019202 Bacterial SH3 domain; Region: SH3_3; cl17532 1173027019203 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 1173027019204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019205 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1173027019206 ATP binding site [chemical binding]; other site 1173027019207 putative Mg++ binding site [ion binding]; other site 1173027019208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027019209 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1173027019210 nucleotide binding region [chemical binding]; other site 1173027019211 ATP-binding site [chemical binding]; other site 1173027019212 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1173027019213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173027019214 nucleotide binding site [chemical binding]; other site 1173027019215 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173027019216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173027019217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173027019218 catalytic residue [active] 1173027019219 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173027019220 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173027019221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173027019222 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1173027019223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027019224 Walker A motif; other site 1173027019225 ATP binding site [chemical binding]; other site 1173027019226 Walker B motif; other site 1173027019227 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1173027019228 RxxxH motif; other site 1173027019229 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1173027019230 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 1173027019231 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173027019232 metal ion-dependent adhesion site (MIDAS); other site 1173027019233 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173027019234 metal ion-dependent adhesion site (MIDAS); other site 1173027019235 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173027019236 metal ion-dependent adhesion site (MIDAS); other site 1173027019237 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 1173027019238 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1173027019239 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1173027019240 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1173027019241 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1173027019242 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1173027019243 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1173027019244 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1173027019245 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1173027019246 putative translocon binding site; other site 1173027019247 protein-rRNA interface [nucleotide binding]; other site 1173027019248 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1173027019249 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1173027019250 G-X-X-G motif; other site 1173027019251 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1173027019252 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1173027019253 23S rRNA interface [nucleotide binding]; other site 1173027019254 5S rRNA interface [nucleotide binding]; other site 1173027019255 putative antibiotic binding site [chemical binding]; other site 1173027019256 L25 interface [polypeptide binding]; other site 1173027019257 L27 interface [polypeptide binding]; other site 1173027019258 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1173027019259 putative translocon interaction site; other site 1173027019260 23S rRNA interface [nucleotide binding]; other site 1173027019261 signal recognition particle (SRP54) interaction site; other site 1173027019262 L23 interface [polypeptide binding]; other site 1173027019263 trigger factor interaction site; other site 1173027019264 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1173027019265 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1173027019266 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1173027019267 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1173027019268 RNA binding site [nucleotide binding]; other site 1173027019269 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1173027019270 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1173027019271 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1173027019272 ribosomal protein S8; Region: rps8; CHL00042 1173027019273 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1173027019274 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173027019275 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173027019276 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1173027019277 23S rRNA interface [nucleotide binding]; other site 1173027019278 5S rRNA interface [nucleotide binding]; other site 1173027019279 L27 interface [polypeptide binding]; other site 1173027019280 L5 interface [polypeptide binding]; other site 1173027019281 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1173027019282 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1173027019283 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1173027019284 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1173027019285 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1173027019286 SecY translocase; Region: SecY; pfam00344 1173027019287 adenylate kinase; Provisional; Region: adk; PRK02496 1173027019288 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1173027019289 AMP-binding site [chemical binding]; other site 1173027019290 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1173027019291 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1173027019292 rRNA binding site [nucleotide binding]; other site 1173027019293 predicted 30S ribosome binding site; other site 1173027019294 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1173027019295 rRNA binding site [nucleotide binding]; other site 1173027019296 predicted 30S ribosome binding site; other site 1173027019297 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1173027019298 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1173027019299 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1173027019300 30S ribosomal protein S11; Validated; Region: PRK05309 1173027019301 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1173027019302 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1173027019303 alphaNTD homodimer interface [polypeptide binding]; other site 1173027019304 alphaNTD - beta interaction site [polypeptide binding]; other site 1173027019305 alphaNTD - beta' interaction site [polypeptide binding]; other site 1173027019306 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1173027019307 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1173027019308 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1173027019309 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1173027019310 dimerization interface 3.5A [polypeptide binding]; other site 1173027019311 active site 1173027019312 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1173027019313 23S rRNA interface [nucleotide binding]; other site 1173027019314 L3 interface [polypeptide binding]; other site 1173027019315 ribosomal protein S9; Region: rps9; CHL00079 1173027019316 ribosomal protein L31; Validated; Region: rpl31; CHL00136 1173027019317 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1173027019318 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1173027019319 RF-1 domain; Region: RF-1; pfam00472 1173027019320 CpeS-like protein; Region: CpeS; pfam09367 1173027019321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173027019322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027019323 active site 1173027019324 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027019325 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173027019326 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173027019327 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173027019328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173027019329 BT1 family; Region: BT1; pfam03092 1173027019330 putative substrate translocation pore; other site 1173027019331 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173027019332 CHASE2 domain; Region: CHASE2; pfam05226 1173027019333 hypothetical protein; Provisional; Region: PHA02756 1173027019334 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1173027019335 cyclase homology domain; Region: CHD; cd07302 1173027019336 nucleotidyl binding site; other site 1173027019337 metal binding site [ion binding]; metal-binding site 1173027019338 dimer interface [polypeptide binding]; other site 1173027019339 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027019340 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173027019341 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173027019342 TPR repeat; Region: TPR_11; pfam13414 1173027019343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027019344 binding surface 1173027019345 TPR motif; other site 1173027019346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027019347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173027019348 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027019349 Ligand Binding Site [chemical binding]; other site 1173027019350 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173027019351 Ligand Binding Site [chemical binding]; other site 1173027019352 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 1173027019353 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027019354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027019355 catalytic loop [active] 1173027019356 iron binding site [ion binding]; other site 1173027019357 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1173027019358 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173027019359 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173027019360 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173027019361 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173027019362 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173027019363 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1173027019364 Protein export membrane protein; Region: SecD_SecF; cl14618 1173027019365 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1173027019366 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173027019367 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 1173027019368 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1173027019369 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1173027019370 dimerization interface [polypeptide binding]; other site 1173027019371 active site 1173027019372 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019373 putative active site [active] 1173027019374 AAA ATPase domain; Region: AAA_16; pfam13191 1173027019375 NACHT domain; Region: NACHT; pfam05729 1173027019376 Walker A motif; other site 1173027019377 ATP binding site [chemical binding]; other site 1173027019378 Walker B motif; other site 1173027019379 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1173027019380 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 1173027019381 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1173027019382 beta-galactosidase; Region: BGL; TIGR03356 1173027019383 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173027019384 putative catalytic residue [active] 1173027019385 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1173027019386 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1173027019387 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1173027019388 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1173027019389 DsbD alpha interface [polypeptide binding]; other site 1173027019390 catalytic residues [active] 1173027019391 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173027019392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027019393 Walker A/P-loop; other site 1173027019394 ATP binding site [chemical binding]; other site 1173027019395 Q-loop/lid; other site 1173027019396 ABC transporter signature motif; other site 1173027019397 Walker B; other site 1173027019398 D-loop; other site 1173027019399 H-loop/switch region; other site 1173027019400 ABC transporter; Region: ABC_tran_2; pfam12848 1173027019401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173027019402 tellurite resistance protein terB; Region: terB; cd07176 1173027019403 putative metal binding site [ion binding]; other site 1173027019404 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1173027019405 active site 1173027019406 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1173027019407 glutaminase; Provisional; Region: PRK00971 1173027019408 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027019409 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019410 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019411 S-formylglutathione hydrolase; Region: PLN02442 1173027019412 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1173027019413 molecular chaperone DnaK; Provisional; Region: PRK13410 1173027019414 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173027019415 nucleotide binding site [chemical binding]; other site 1173027019416 NEF interaction site [polypeptide binding]; other site 1173027019417 SBD interface [polypeptide binding]; other site 1173027019418 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173027019419 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173027019420 HSP70 interaction site [polypeptide binding]; other site 1173027019421 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173027019422 dimer interface [polypeptide binding]; other site 1173027019423 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1173027019424 arginine-tRNA ligase; Region: PLN02286 1173027019425 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1173027019426 active site 1173027019427 HIGH motif; other site 1173027019428 KMSK motif region; other site 1173027019429 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1173027019430 tRNA binding surface [nucleotide binding]; other site 1173027019431 anticodon binding site; other site 1173027019432 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1173027019433 active site 1173027019434 catalytic residues [active] 1173027019435 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173027019436 active site 1173027019437 catalytic residues [active] 1173027019438 metal binding site [ion binding]; metal-binding site 1173027019439 large tegument protein UL36; Provisional; Region: PHA03247 1173027019440 AAA-like domain; Region: AAA_10; pfam12846 1173027019441 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 1173027019442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019443 putative active site [active] 1173027019444 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1173027019445 putative metal binding site [ion binding]; other site 1173027019446 thymidylate synthase; Provisional; Region: thyA; PRK00956 1173027019447 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1173027019448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027019449 non-specific DNA binding site [nucleotide binding]; other site 1173027019450 salt bridge; other site 1173027019451 sequence-specific DNA binding site [nucleotide binding]; other site 1173027019452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1173027019453 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1173027019454 putative active site [active] 1173027019455 homotetrameric interface [polypeptide binding]; other site 1173027019456 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173027019457 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1173027019458 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1173027019459 ParB-like nuclease domain; Region: ParBc; pfam02195 1173027019460 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1173027019461 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027019462 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027019463 P-loop; other site 1173027019464 Magnesium ion binding site [ion binding]; other site 1173027019465 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027019466 Magnesium ion binding site [ion binding]; other site 1173027019467 hypothetical protein; Provisional; Region: PRK11281 1173027019468 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1173027019469 ATP-binding site [chemical binding]; other site 1173027019470 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173027019471 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027019472 cofactor binding site; other site 1173027019473 DNA binding site [nucleotide binding] 1173027019474 substrate interaction site [chemical binding]; other site 1173027019475 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027019476 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1173027019477 PLD-like domain; Region: PLDc_2; pfam13091 1173027019478 putative active site [active] 1173027019479 catalytic site [active] 1173027019480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027019481 active site 1173027019482 Int/Topo IB signature motif; other site 1173027019483 DNA binding site [nucleotide binding] 1173027019484 hypothetical protein; Provisional; Region: PRK10236 1173027019485 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1173027019486 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1173027019487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027019488 Walker A motif; other site 1173027019489 ATP binding site [chemical binding]; other site 1173027019490 Walker B motif; other site 1173027019491 arginine finger; other site 1173027019492 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173027019493 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1173027019494 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1173027019495 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1173027019496 active site 1173027019497 catalytic site [active] 1173027019498 substrate binding site [chemical binding]; other site 1173027019499 Phylum Aquificae Pol A is different from Escherichia coli Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639 1173027019500 active site 1173027019501 DNA binding site [nucleotide binding] 1173027019502 catalytic site [active] 1173027019503 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1173027019504 putative active site [active] 1173027019505 putative catalytic site [active] 1173027019506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173027019507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173027019508 active site 1173027019509 ATP binding site [chemical binding]; other site 1173027019510 substrate binding site [chemical binding]; other site 1173027019511 activation loop (A-loop); other site 1173027019512 AAA domain; Region: AAA_11; pfam13086 1173027019513 Part of AAA domain; Region: AAA_19; pfam13245 1173027019514 AAA domain; Region: AAA_12; pfam13087 1173027019515 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173027019516 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173027019517 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173027019518 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173027019519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019520 ATP binding site [chemical binding]; other site 1173027019521 putative Mg++ binding site [ion binding]; other site 1173027019522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027019523 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1173027019524 nucleotide binding region [chemical binding]; other site 1173027019525 ATP-binding site [chemical binding]; other site 1173027019526 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173027019527 dimer interface [polypeptide binding]; other site 1173027019528 ssDNA binding site [nucleotide binding]; other site 1173027019529 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173027019530 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1173027019531 AAA ATPase domain; Region: AAA_16; pfam13191 1173027019532 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1173027019533 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019534 putative active site [active] 1173027019535 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1173027019536 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173027019537 Caspase domain; Region: Peptidase_C14; pfam00656 1173027019538 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 1173027019539 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1173027019540 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 1173027019541 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173027019542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019543 ATP binding site [chemical binding]; other site 1173027019544 putative Mg++ binding site [ion binding]; other site 1173027019545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027019546 nucleotide binding region [chemical binding]; other site 1173027019547 ATP-binding site [chemical binding]; other site 1173027019548 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173027019549 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027019550 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173027019551 DXD motif; other site 1173027019552 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1173027019553 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1173027019554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173027019555 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027019556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027019557 active site 1173027019558 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173027019559 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173027019560 putative DNA binding surface [nucleotide binding]; other site 1173027019561 dimer interface [polypeptide binding]; other site 1173027019562 beta-clamp/clamp loader binding surface; other site 1173027019563 beta-clamp/translesion DNA polymerase binding surface; other site 1173027019564 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1173027019565 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1173027019566 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 1173027019567 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1173027019568 ADP-ribose binding site [chemical binding]; other site 1173027019569 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1173027019570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027019571 AAA domain; Region: AAA_21; pfam13304 1173027019572 Walker A/P-loop; other site 1173027019573 ATP binding site [chemical binding]; other site 1173027019574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173027019575 Q-loop/lid; other site 1173027019576 ABC transporter signature motif; other site 1173027019577 Walker B; other site 1173027019578 D-loop; other site 1173027019579 H-loop/switch region; other site 1173027019580 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173027019581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027019582 CHAT domain; Region: CHAT; cl17868 1173027019583 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173027019584 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019585 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027019586 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019587 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019588 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019589 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 1173027019590 nucleotide sensor; other site 1173027019591 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173027019592 Mg binding site [ion binding]; other site 1173027019593 nucleotide binding site [chemical binding]; other site 1173027019594 putative protofilament interface [polypeptide binding]; other site 1173027019595 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1173027019596 Family description; Region: VCBS; pfam13517 1173027019597 Family description; Region: VCBS; pfam13517 1173027019598 Family description; Region: VCBS; pfam13517 1173027019599 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1173027019600 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1173027019601 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1173027019602 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1173027019603 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1173027019604 PA14 domain; Region: PA14; cl08459 1173027019605 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1173027019606 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1173027019607 active site 1173027019608 metal binding site [ion binding]; metal-binding site 1173027019609 Toprim-like; Region: Toprim_2; pfam13155 1173027019610 HEAT repeats; Region: HEAT_2; pfam13646 1173027019611 HEAT repeats; Region: HEAT_2; pfam13646 1173027019612 HEAT repeats; Region: HEAT_2; pfam13646 1173027019613 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173027019614 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027019615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019616 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027019617 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019618 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019619 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173027019620 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173027019621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173027019622 Walker A motif; other site 1173027019623 ATP binding site [chemical binding]; other site 1173027019624 Walker B motif; other site 1173027019625 arginine finger; other site 1173027019626 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1173027019627 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1173027019628 classical (c) SDRs; Region: SDR_c; cd05233 1173027019629 NAD(P) binding site [chemical binding]; other site 1173027019630 active site 1173027019631 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027019632 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027019633 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027019634 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027019635 P-loop; other site 1173027019636 Magnesium ion binding site [ion binding]; other site 1173027019637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027019638 non-specific DNA binding site [nucleotide binding]; other site 1173027019639 salt bridge; other site 1173027019640 sequence-specific DNA binding site [nucleotide binding]; other site 1173027019641 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1173027019642 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1173027019643 putative active site [active] 1173027019644 putative NTP binding site [chemical binding]; other site 1173027019645 putative nucleic acid binding site [nucleotide binding]; other site 1173027019646 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173027019647 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173027019648 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173027019649 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 1173027019650 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1173027019651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1173027019652 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1173027019653 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1173027019654 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1173027019655 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 1173027019656 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 1173027019657 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1173027019658 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 1173027019659 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1173027019660 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173027019661 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1173027019662 Integrase core domain; Region: rve; pfam00665 1173027019663 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027019664 TniQ; Region: TniQ; pfam06527 1173027019665 WYL domain; Region: WYL; cl14852 1173027019666 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740 1173027019667 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740 1173027019668 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173027019669 HD domain; Region: HD_4; pfam13328 1173027019670 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1173027019671 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173027019672 active site 1173027019673 catalytic residues [active] 1173027019674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173027019675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173027019676 CHAP domain; Region: CHAP; pfam05257 1173027019677 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027019678 putative active site [active] 1173027019679 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1173027019680 glutathione s-transferase; Provisional; Region: PTZ00057 1173027019681 GSH binding site (G-site) [chemical binding]; other site 1173027019682 C-terminal domain interface [polypeptide binding]; other site 1173027019683 dimer interface [polypeptide binding]; other site 1173027019684 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1173027019685 dimer interface [polypeptide binding]; other site 1173027019686 N-terminal domain interface [polypeptide binding]; other site 1173027019687 substrate binding pocket (H-site) [chemical binding]; other site 1173027019688 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 1173027019689 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027019690 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1173027019691 four helix bundle protein; Region: TIGR02436 1173027019692 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173027019693 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173027019694 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173027019695 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173027019696 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1173027019697 Integrase core domain; Region: rve; pfam00665 1173027019698 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027019699 TniQ; Region: TniQ; pfam06527 1173027019700 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1173027019701 AAA domain; Region: AAA_30; pfam13604 1173027019702 Family description; Region: UvrD_C_2; pfam13538 1173027019703 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173027019704 cofactor binding site; other site 1173027019705 DNA binding site [nucleotide binding] 1173027019706 substrate interaction site [chemical binding]; other site 1173027019707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027019708 non-specific DNA binding site [nucleotide binding]; other site 1173027019709 salt bridge; other site 1173027019710 sequence-specific DNA binding site [nucleotide binding]; other site 1173027019711 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173027019712 Mg binding site [ion binding]; other site 1173027019713 nucleotide binding site [chemical binding]; other site 1173027019714 putative protofilament interface [polypeptide binding]; other site 1173027019715 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173027019716 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173027019717 C-terminal domain interface [polypeptide binding]; other site 1173027019718 GSH binding site (G-site) [chemical binding]; other site 1173027019719 dimer interface [polypeptide binding]; other site 1173027019720 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173027019721 N-terminal domain interface [polypeptide binding]; other site 1173027019722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173027019723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173027019724 dimer interface [polypeptide binding]; other site 1173027019725 phosphorylation site [posttranslational modification] 1173027019726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019727 ATP binding site [chemical binding]; other site 1173027019728 Mg2+ binding site [ion binding]; other site 1173027019729 G-X-G motif; other site 1173027019730 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027019731 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027019732 structural tetrad; other site 1173027019733 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027019734 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027019735 structural tetrad; other site 1173027019736 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027019737 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027019738 structural tetrad; other site 1173027019739 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027019740 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173027019741 structural tetrad; other site 1173027019742 WD40 repeats; Region: WD40; smart00320 1173027019743 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027019744 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019745 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019746 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019747 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027019748 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027019750 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1173027019751 putative active site [active] 1173027019752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027019753 active site 1173027019754 DNA binding site [nucleotide binding] 1173027019755 Int/Topo IB signature motif; other site 1173027019756 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1173027019757 AAA domain; Region: AAA_30; pfam13604 1173027019758 Family description; Region: UvrD_C_2; pfam13538 1173027019759 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1173027019760 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027019761 active site 1173027019762 DNA binding site [nucleotide binding] 1173027019763 Int/Topo IB signature motif; other site 1173027019764 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1173027019765 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 1173027019766 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173027019767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1173027019768 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027019769 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027019770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027019771 Magnesium ion binding site [ion binding]; other site 1173027019772 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1173027019773 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027019774 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1173027019775 polymerase nucleotide-binding site; other site 1173027019776 DNA-binding residues [nucleotide binding]; DNA binding site 1173027019777 nucleotide binding site [chemical binding]; other site 1173027019778 primase nucleotide-binding site [nucleotide binding]; other site 1173027019779 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 1173027019780 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1173027019781 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173027019782 Mg binding site [ion binding]; other site 1173027019783 nucleotide binding site [chemical binding]; other site 1173027019784 putative protofilament interface [polypeptide binding]; other site 1173027019785 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173027019786 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173027019787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027019788 non-specific DNA binding site [nucleotide binding]; other site 1173027019789 salt bridge; other site 1173027019790 sequence-specific DNA binding site [nucleotide binding]; other site 1173027019791 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1173027019792 Dynamin family; Region: Dynamin_N; pfam00350 1173027019793 G1 box; other site 1173027019794 GTP/Mg2+ binding site [chemical binding]; other site 1173027019795 G2 box; other site 1173027019796 Switch I region; other site 1173027019797 G3 box; other site 1173027019798 Switch II region; other site 1173027019799 G4 box; other site 1173027019800 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1173027019801 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1173027019802 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173027019803 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1173027019804 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1173027019805 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173027019806 active site 1173027019807 NTP binding site [chemical binding]; other site 1173027019808 metal binding triad [ion binding]; metal-binding site 1173027019809 antibiotic binding site [chemical binding]; other site 1173027019810 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1173027019811 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1173027019812 Abortive infection C-terminus; Region: Abi_C; pfam14355 1173027019813 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1173027019814 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1173027019815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019816 ATP binding site [chemical binding]; other site 1173027019817 putative Mg++ binding site [ion binding]; other site 1173027019818 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1173027019819 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173027019820 NACHT domain; Region: NACHT; pfam05729 1173027019821 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173027019822 oligomeric interface; other site 1173027019823 putative active site [active] 1173027019824 homodimer interface [polypeptide binding]; other site 1173027019825 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 1173027019826 putative active site [active] 1173027019827 catalytic site [active] 1173027019828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173027019829 ATP binding site [chemical binding]; other site 1173027019830 putative Mg++ binding site [ion binding]; other site 1173027019831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027019832 nucleotide binding region [chemical binding]; other site 1173027019833 ATP-binding site [chemical binding]; other site 1173027019834 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027019835 active site 1173027019836 catalytic residues [active] 1173027019837 DNA binding site [nucleotide binding] 1173027019838 Int/Topo IB signature motif; other site 1173027019839 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173027019840 Mg binding site [ion binding]; other site 1173027019841 nucleotide binding site [chemical binding]; other site 1173027019842 putative protofilament interface [polypeptide binding]; other site 1173027019843 Homeodomain-like domain; Region: HTH_23; pfam13384 1173027019844 Winged helix-turn helix; Region: HTH_29; pfam13551 1173027019845 Homeodomain-like domain; Region: HTH_32; pfam13565 1173027019846 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173027019847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173027019848 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173027019849 D5 N terminal like; Region: D5_N; smart00885 1173027019850 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1173027019851 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1173027019852 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027019853 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027019854 active site 1173027019855 catalytic residues [active] 1173027019856 DNA binding site [nucleotide binding] 1173027019857 Int/Topo IB signature motif; other site 1173027019858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173027019859 non-specific DNA binding site [nucleotide binding]; other site 1173027019860 salt bridge; other site 1173027019861 sequence-specific DNA binding site [nucleotide binding]; other site 1173027019862 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1173027019863 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1173027019864 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1173027019865 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1173027019866 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1173027019867 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027019868 active site 1173027019869 catalytic residues [active] 1173027019870 DNA binding site [nucleotide binding] 1173027019871 Int/Topo IB signature motif; other site 1173027019872 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173027019873 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027019874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019875 active site 1173027019876 phosphorylation site [posttranslational modification] 1173027019877 intermolecular recognition site; other site 1173027019878 dimerization interface [polypeptide binding]; other site 1173027019879 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173027019880 phosphopeptide binding site; other site 1173027019881 HTH domain; Region: HTH_11; cl17392 1173027019882 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173027019883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027019884 active site 1173027019885 DNA binding site [nucleotide binding] 1173027019886 Int/Topo IB signature motif; other site 1173027019887 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173027019888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173027019889 catalytic loop [active] 1173027019890 iron binding site [ion binding]; other site 1173027019891 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173027019892 protein I interface; other site 1173027019893 D2 interface; other site 1173027019894 protein T interface; other site 1173027019895 chlorophyll binding site; other site 1173027019896 beta carotene binding site; other site 1173027019897 pheophytin binding site; other site 1173027019898 manganese-stabilizing polypeptide interface; other site 1173027019899 CP43 interface; other site 1173027019900 protein L interface; other site 1173027019901 oxygen evolving complex binding site; other site 1173027019902 bromide binding site; other site 1173027019903 quinone binding site; other site 1173027019904 Fe binding site [ion binding]; other site 1173027019905 core light harvesting interface; other site 1173027019906 cytochrome b559 alpha subunit interface; other site 1173027019907 cytochrome c-550 interface; other site 1173027019908 protein J interface; other site 1173027019909 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1173027019910 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1173027019911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173027019912 Coenzyme A binding pocket [chemical binding]; other site 1173027019913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1173027019914 TPR repeat; Region: TPR_11; pfam13414 1173027019915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027019916 TPR motif; other site 1173027019917 binding surface 1173027019918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027019919 TPR motif; other site 1173027019920 binding surface 1173027019921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173027019922 binding surface 1173027019923 TPR motif; other site 1173027019924 TPR repeat; Region: TPR_11; pfam13414 1173027019925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027019926 binding surface 1173027019927 TPR motif; other site 1173027019928 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173027019929 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173027019930 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173027019931 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 1173027019932 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1173027019933 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1173027019934 DXD motif; other site 1173027019935 PilZ domain; Region: PilZ; pfam07238 1173027019936 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027019937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019938 active site 1173027019939 phosphorylation site [posttranslational modification] 1173027019940 intermolecular recognition site; other site 1173027019941 dimerization interface [polypeptide binding]; other site 1173027019942 Response regulator receiver domain; Region: Response_reg; pfam00072 1173027019943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019944 active site 1173027019945 phosphorylation site [posttranslational modification] 1173027019946 intermolecular recognition site; other site 1173027019947 dimerization interface [polypeptide binding]; other site 1173027019948 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173027019949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027019950 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027019951 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173027019952 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173027019953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173027019954 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173027019955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173027019956 dimer interface [polypeptide binding]; other site 1173027019957 putative CheW interface [polypeptide binding]; other site 1173027019958 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173027019959 putative binding surface; other site 1173027019960 active site 1173027019961 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173027019962 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173027019963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173027019964 ATP binding site [chemical binding]; other site 1173027019965 Mg2+ binding site [ion binding]; other site 1173027019966 G-X-G motif; other site 1173027019967 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173027019968 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173027019969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173027019970 active site 1173027019971 phosphorylation site [posttranslational modification] 1173027019972 intermolecular recognition site; other site 1173027019973 dimerization interface [polypeptide binding]; other site 1173027019974 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1173027019975 DNA-binding residues [nucleotide binding]; DNA binding site 1173027019976 nucleotide binding site [chemical binding]; other site 1173027019977 polymerase nucleotide-binding site; other site 1173027019978 primase nucleotide-binding site [nucleotide binding]; other site 1173027019979 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1173027019980 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027019981 Short C-terminal domain; Region: SHOCT; pfam09851 1173027019982 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1173027019983 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1173027019984 NAD binding site [chemical binding]; other site 1173027019985 substrate binding site [chemical binding]; other site 1173027019986 homodimer interface [polypeptide binding]; other site 1173027019987 active site 1173027019988 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173027019989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027019990 active site 1173027019991 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1173027019992 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173027019993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027019994 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173027019995 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173027019996 inhibitor-cofactor binding pocket; inhibition site 1173027019997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173027019998 catalytic residue [active] 1173027019999 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173027020000 putative ADP-binding pocket [chemical binding]; other site 1173027020001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027020002 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027020003 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1173027020004 DXD motif; other site 1173027020005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027020006 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020007 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020009 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020010 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020011 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020012 ParA-like protein; Provisional; Region: PHA02518 1173027020013 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027020014 P-loop; other site 1173027020015 Magnesium ion binding site [ion binding]; other site 1173027020016 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027020017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020018 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020019 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020022 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027020023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020025 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173027020026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020029 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020030 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 1173027020031 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1173027020032 substrate binding site; other site 1173027020033 metal-binding site 1173027020034 Oligomer interface; other site 1173027020035 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173027020036 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173027020037 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1173027020038 NADP binding site [chemical binding]; other site 1173027020039 active site 1173027020040 putative substrate binding site [chemical binding]; other site 1173027020041 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1173027020042 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027020043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173027020044 active site 1173027020045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173027020046 putative acyl transferase; Provisional; Region: PRK10191 1173027020047 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173027020048 trimer interface [polypeptide binding]; other site 1173027020049 active site 1173027020050 substrate binding site [chemical binding]; other site 1173027020051 CoA binding site [chemical binding]; other site 1173027020052 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173027020053 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173027020054 Probable Catalytic site; other site 1173027020055 metal-binding site 1173027020056 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027020057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027020058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027020059 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173027020060 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173027020061 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173027020062 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173027020063 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173027020064 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173027020065 putative ADP-binding pocket [chemical binding]; other site 1173027020066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173027020067 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027020068 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173027020069 Chain length determinant protein; Region: Wzz; cl15801 1173027020070 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173027020071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173027020072 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027020073 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173027020074 AAA ATPase domain; Region: AAA_16; pfam13191 1173027020075 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173027020076 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173027020077 oligomeric interface; other site 1173027020078 putative active site [active] 1173027020079 homodimer interface [polypeptide binding]; other site 1173027020080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027020081 AAA domain; Region: AAA_31; pfam13614 1173027020082 P-loop; other site 1173027020083 Magnesium ion binding site [ion binding]; other site 1173027020084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027020085 Magnesium ion binding site [ion binding]; other site 1173027020086 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1173027020087 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1173027020088 active site 1173027020089 dimer interface [polypeptide binding]; other site 1173027020090 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173027020091 Ligand Binding Site [chemical binding]; other site 1173027020092 Molecular Tunnel; other site 1173027020093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1173027020094 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1173027020095 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173027020096 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173027020097 putative dimer interface [polypeptide binding]; other site 1173027020098 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1173027020099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027020100 active site 1173027020101 DNA binding site [nucleotide binding] 1173027020102 Int/Topo IB signature motif; other site 1173027020103 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1173027020104 Integrase core domain; Region: rve; pfam00665 1173027020105 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1173027020106 Bacterial TniB protein; Region: TniB; pfam05621 1173027020107 AAA domain; Region: AAA_22; pfam13401 1173027020108 TniQ; Region: TniQ; pfam06527 1173027020109 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1173027020110 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1173027020111 SOUL heme-binding protein; Region: SOUL; pfam04832 1173027020112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027020113 binding surface 1173027020114 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027020115 TPR motif; other site 1173027020116 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027020117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027020118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027020119 binding surface 1173027020120 TPR motif; other site 1173027020121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027020122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173027020123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027020124 binding surface 1173027020125 TPR motif; other site 1173027020126 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1173027020127 catalytic residue [active] 1173027020128 H2TH interface [polypeptide binding]; other site 1173027020129 putative catalytic residues [active] 1173027020130 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1173027020131 active site 1173027020132 metal binding site [ion binding]; metal-binding site 1173027020133 interdomain interaction site; other site 1173027020134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173027020135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020136 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020138 TIR domain; Region: TIR_2; pfam13676 1173027020139 TIR domain; Region: TIR_2; pfam13676 1173027020140 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027020141 putative active site [active] 1173027020142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173027020143 binding surface 1173027020144 TPR repeat; Region: TPR_11; pfam13414 1173027020145 TPR motif; other site 1173027020146 Caspase domain; Region: Peptidase_C14; pfam00656 1173027020147 AAA ATPase domain; Region: AAA_16; pfam13191 1173027020148 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027020149 structural tetrad; other site 1173027020150 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173027020151 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173027020152 structural tetrad; other site 1173027020153 Caspase domain; Region: Peptidase_C14; pfam00656 1173027020154 V-type ATP synthase subunit I; Validated; Region: PRK05771 1173027020155 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1173027020156 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1173027020157 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173027020158 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1173027020159 catalytic residues [active] 1173027020160 catalytic nucleophile [active] 1173027020161 Recombinase; Region: Recombinase; pfam07508 1173027020162 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1173027020163 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173027020164 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020165 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020166 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173027020167 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173027020169 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173027020170 active site 1173027020171 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1173027020172 DNA-sulfur modification-associated; Region: DndB; pfam14072 1173027020173 DGQHR domain; Region: DGQHR; TIGR03187 1173027020174 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1173027020175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173027020176 ATP-binding site [chemical binding]; other site 1173027020177 PLD-like domain; Region: PLDc_2; pfam13091 1173027020178 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173027020179 putative active site [active] 1173027020180 catalytic site [active] 1173027020181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1173027020182 homodimer interface [polypeptide binding]; other site 1173027020183 metal binding site [ion binding]; metal-binding site 1173027020184 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1173027020185 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027020186 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027020187 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027020188 active site 1173027020189 catalytic residues [active] 1173027020190 DNA binding site [nucleotide binding] 1173027020191 Int/Topo IB signature motif; other site 1173027020192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173027020193 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1173027020194 D5 N terminal like; Region: D5_N; smart00885 1173027020195 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1173027020196 Phosphoglucose isomerase; Region: PGI; pfam00342 1173027020197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173027020198 active site 1173027020199 catalytic residues [active] 1173027020200 DNA binding site [nucleotide binding] 1173027020201 Int/Topo IB signature motif; other site 1173027020202 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173027020203 putative active site [active] 1173027020204 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173027020205 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1173027020206 ParB-like nuclease domain; Region: ParBc; pfam02195 1173027020207 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173027020208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027020209 P-loop; other site 1173027020210 Magnesium ion binding site [ion binding]; other site 1173027020211 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173027020212 Magnesium ion binding site [ion binding]; other site