-- dump date   	20140619_145838
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
449447000001	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
449447000002	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
449447000003	substrate binding pocket [chemical binding]; other site
449447000004	chain length determination region; other site
449447000005	substrate-Mg2+ binding site; other site
449447000006	catalytic residues [active]
449447000007	aspartate-rich region 1; other site
449447000008	active site lid residues [active]
449447000009	aspartate-rich region 2; other site
449447000010	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447000011	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447000012	catalytic loop [active]
449447000013	iron binding site [ion binding]; other site
449447000014	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
449447000015	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
449447000016	active site
449447000017	catalytic residues [active]
449447000018	metal binding site [ion binding]; metal-binding site
449447000019	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
449447000020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000021	binding surface
449447000022	TPR repeat; Region: TPR_11; pfam13414
449447000023	TPR motif; other site
449447000024	TPR repeat; Region: TPR_11; pfam13414
449447000025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000026	TPR repeat; Region: TPR_11; pfam13414
449447000027	binding surface
449447000028	TPR motif; other site
449447000029	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447000030	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
449447000031	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000032	putative active site [active]
449447000033	acyl-CoA synthetase; Validated; Region: PRK05850
449447000034	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
449447000035	acyl-activating enzyme (AAE) consensus motif; other site
449447000036	active site
449447000037	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447000038	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447000039	active site
449447000040	YcfA-like protein; Region: YcfA; cl00752
449447000041	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447000042	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
449447000043	lipoprotein signal peptidase; Provisional; Region: PRK14787
449447000044	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
449447000045	biotin synthase; Region: bioB; TIGR00433
449447000046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447000047	FeS/SAM binding site; other site
449447000048	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
449447000049	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
449447000050	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
449447000051	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
449447000052	NADP binding site [chemical binding]; other site
449447000053	active site
449447000054	putative substrate binding site [chemical binding]; other site
449447000055	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
449447000056	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
449447000057	substrate binding site; other site
449447000058	metal-binding site
449447000059	Oligomer interface; other site
449447000060	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447000061	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
449447000062	tartrate dehydrogenase; Region: TTC; TIGR02089
449447000063	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
449447000064	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
449447000065	GIY-YIG motif/motif A; other site
449447000066	active site
449447000067	catalytic site [active]
449447000068	putative DNA binding site [nucleotide binding]; other site
449447000069	metal binding site [ion binding]; metal-binding site
449447000070	UvrB/uvrC motif; Region: UVR; pfam02151
449447000071	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
449447000072	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
449447000073	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
449447000074	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
449447000075	Low molecular weight phosphatase family; Region: LMWPc; cd00115
449447000076	active site
449447000077	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447000078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447000079	active site
449447000080	phosphorylation site [posttranslational modification]
449447000081	intermolecular recognition site; other site
449447000082	dimerization interface [polypeptide binding]; other site
449447000083	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447000084	DNA binding residues [nucleotide binding]
449447000085	dimerization interface [polypeptide binding]; other site
449447000086	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
449447000087	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447000088	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447000089	TM-ABC transporter signature motif; other site
449447000090	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
449447000091	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
449447000092	Walker A/P-loop; other site
449447000093	ATP binding site [chemical binding]; other site
449447000094	Q-loop/lid; other site
449447000095	ABC transporter signature motif; other site
449447000096	Walker B; other site
449447000097	D-loop; other site
449447000098	H-loop/switch region; other site
449447000099	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
449447000100	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
449447000101	putative active site [active]
449447000102	oxyanion strand; other site
449447000103	catalytic triad [active]
449447000104	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
449447000105	AAA domain; Region: AAA_21; pfam13304
449447000106	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000107	putative active site [active]
449447000108	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000109	putative active site [active]
449447000110	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000111	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000112	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447000113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000114	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000115	YcfA-like protein; Region: YcfA; cl00752
449447000116	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
449447000117	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
449447000118	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447000119	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447000120	active site
449447000121	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447000122	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000123	putative active site [active]
449447000124	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447000125	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000126	putative active site [active]
449447000127	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000128	catalytic residues [active]
449447000129	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000130	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000131	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447000132	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
449447000133	putative active site [active]
449447000134	putative catalytic triad [active]
449447000135	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447000136	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
449447000137	cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220
449447000138	von Willebrand factor type A domain; Region: VWA_2; pfam13519
449447000139	Putative restriction endonuclease; Region: Uma2; pfam05685
449447000140	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000141	active site
449447000142	catalytic residues [active]
449447000143	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
449447000144	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447000145	catalytic residues [active]
449447000146	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447000147	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447000148	active site
449447000149	catalytic tetrad [active]
449447000150	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
449447000151	putative active site pocket [active]
449447000152	dimerization interface [polypeptide binding]; other site
449447000153	putative catalytic residue [active]
449447000154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000155	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000156	Probable transposase; Region: OrfB_IS605; pfam01385
449447000157	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447000158	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
449447000159	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447000160	DNA binding site [nucleotide binding]
449447000161	substrate interaction site [chemical binding]; other site
449447000162	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447000163	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447000164	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447000165	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000166	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
449447000167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447000168	non-specific DNA binding site [nucleotide binding]; other site
449447000169	salt bridge; other site
449447000170	sequence-specific DNA binding site [nucleotide binding]; other site
449447000171	GTP-binding protein Der; Reviewed; Region: PRK00093
449447000172	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
449447000173	G1 box; other site
449447000174	GTP/Mg2+ binding site [chemical binding]; other site
449447000175	Switch I region; other site
449447000176	G2 box; other site
449447000177	Switch II region; other site
449447000178	G3 box; other site
449447000179	G4 box; other site
449447000180	G5 box; other site
449447000181	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
449447000182	G1 box; other site
449447000183	GTP/Mg2+ binding site [chemical binding]; other site
449447000184	Switch I region; other site
449447000185	G2 box; other site
449447000186	G3 box; other site
449447000187	Switch II region; other site
449447000188	G4 box; other site
449447000189	G5 box; other site
449447000190	Cobalt transport protein; Region: CbiQ; pfam02361
449447000191	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
449447000192	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447000193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447000194	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447000195	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447000196	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
449447000197	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
449447000198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000199	ATP binding site [chemical binding]; other site
449447000200	putative Mg++ binding site [ion binding]; other site
449447000201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000202	nucleotide binding region [chemical binding]; other site
449447000203	ATP-binding site [chemical binding]; other site
449447000204	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
449447000205	HRDC domain; Region: HRDC; pfam00570
449447000206	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
449447000207	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
449447000208	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
449447000209	alpha subunit interaction interface [polypeptide binding]; other site
449447000210	Walker A motif; other site
449447000211	ATP binding site [chemical binding]; other site
449447000212	Walker B motif; other site
449447000213	inhibitor binding site; inhibition site
449447000214	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
449447000215	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
449447000216	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
449447000217	gamma subunit interface [polypeptide binding]; other site
449447000218	epsilon subunit interface [polypeptide binding]; other site
449447000219	LBP interface [polypeptide binding]; other site
449447000220	hypothetical protein; Provisional; Region: PRK02724
449447000221	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
449447000222	active site
449447000223	8-oxo-dGMP binding site [chemical binding]; other site
449447000224	nudix motif; other site
449447000225	metal binding site [ion binding]; metal-binding site
449447000226	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
449447000227	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
449447000228	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
449447000229	Mg++ binding site [ion binding]; other site
449447000230	putative catalytic motif [active]
449447000231	putative substrate binding site [chemical binding]; other site
449447000232	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
449447000233	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447000234	SprT homologues; Region: SprT; cl01182
449447000235	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
449447000236	Calx-beta domain; Region: Calx-beta; cl02522
449447000237	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
449447000238	nucleophilic elbow; other site
449447000239	catalytic triad; other site
449447000240	Calx-beta domain; Region: Calx-beta; cl02522
449447000241	Calx-beta domain; Region: Calx-beta; cl02522
449447000242	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000243	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000244	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000245	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000246	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447000247	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447000248	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447000249	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
449447000250	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
449447000251	putative dimer interface [polypeptide binding]; other site
449447000252	[2Fe-2S] cluster binding site [ion binding]; other site
449447000253	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447000254	dimer interface [polypeptide binding]; other site
449447000255	[2Fe-2S] cluster binding site [ion binding]; other site
449447000256	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
449447000257	SLBB domain; Region: SLBB; pfam10531
449447000258	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
449447000259	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000260	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000261	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000262	Probable transposase; Region: OrfB_IS605; pfam01385
449447000263	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447000264	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
449447000265	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
449447000266	phosphate binding site [ion binding]; other site
449447000267	putative substrate binding pocket [chemical binding]; other site
449447000268	dimer interface [polypeptide binding]; other site
449447000269	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
449447000270	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
449447000271	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
449447000272	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
449447000273	active site
449447000274	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447000275	dimer interface [polypeptide binding]; other site
449447000276	substrate binding site [chemical binding]; other site
449447000277	catalytic residue [active]
449447000278	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
449447000279	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
449447000280	Walker A/P-loop; other site
449447000281	ATP binding site [chemical binding]; other site
449447000282	Q-loop/lid; other site
449447000283	ABC transporter signature motif; other site
449447000284	Walker B; other site
449447000285	D-loop; other site
449447000286	H-loop/switch region; other site
449447000287	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447000288	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447000289	active site
449447000290	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
449447000291	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
449447000292	active site
449447000293	HIGH motif; other site
449447000294	dimer interface [polypeptide binding]; other site
449447000295	KMSKS motif; other site
449447000296	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
449447000297	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
449447000298	Protein of unknown function (DUF422); Region: DUF422; cl00991
449447000299	hydrolase, alpha/beta fold family protein; Region: PLN02824
449447000300	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
449447000301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447000302	ABC transporter signature motif; other site
449447000303	Walker B; other site
449447000304	D-loop; other site
449447000305	H-loop/switch region; other site
449447000306	polyphosphate kinase; Provisional; Region: PRK05443
449447000307	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
449447000308	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
449447000309	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
449447000310	putative domain interface [polypeptide binding]; other site
449447000311	putative active site [active]
449447000312	catalytic site [active]
449447000313	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
449447000314	putative domain interface [polypeptide binding]; other site
449447000315	putative active site [active]
449447000316	catalytic site [active]
449447000317	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447000318	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447000319	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
449447000320	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447000321	putative active site [active]
449447000322	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
449447000323	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
449447000324	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
449447000325	Homeodomain-like domain; Region: HTH_23; pfam13384
449447000326	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000327	Homeodomain-like domain; Region: HTH_32; pfam13565
449447000328	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000329	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000332	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000333	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447000334	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000336	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000337	Homeodomain-like domain; Region: HTH_23; pfam13384
449447000338	Homeodomain-like domain; Region: HTH_32; pfam13565
449447000339	Paired Box domain; Region: PAX; cd00131
449447000340	DNA binding site [nucleotide binding]
449447000341	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000342	Homeodomain-like domain; Region: HTH_32; pfam13565
449447000343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000344	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000345	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000346	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
449447000347	Beta/Gamma crystallin; Region: Crystall; cl02528
449447000348	Beta/Gamma crystallin; Region: Crystall; cl02528
449447000349	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
449447000350	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000351	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000353	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000354	PemK-like protein; Region: PemK; cl00995
449447000355	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000356	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447000357	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447000358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000359	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000360	integral membrane protein MviN; Region: mviN; TIGR01695
449447000361	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
449447000362	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
449447000363	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
449447000364	dimer interface [polypeptide binding]; other site
449447000365	motif 1; other site
449447000366	active site
449447000367	motif 2; other site
449447000368	motif 3; other site
449447000369	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
449447000370	anticodon binding site; other site
449447000371	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
449447000372	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447000373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447000374	motif II; other site
449447000375	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000376	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000377	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000378	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000379	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447000380	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447000381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000382	binding surface
449447000383	TPR motif; other site
449447000384	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447000385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000386	binding surface
449447000387	TPR motif; other site
449447000388	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447000389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000390	binding surface
449447000391	TPR motif; other site
449447000392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000393	binding surface
449447000394	TPR motif; other site
449447000395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000396	binding surface
449447000397	TPR motif; other site
449447000398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000399	binding surface
449447000400	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447000401	TPR motif; other site
449447000402	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
449447000403	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
449447000404	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
449447000405	NAD binding site [chemical binding]; other site
449447000406	homotetramer interface [polypeptide binding]; other site
449447000407	homodimer interface [polypeptide binding]; other site
449447000408	substrate binding site [chemical binding]; other site
449447000409	active site
449447000410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447000411	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
449447000412	ligand binding site [chemical binding]; other site
449447000413	flexible hinge region; other site
449447000414	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447000415	putative switch regulator; other site
449447000416	non-specific DNA interactions [nucleotide binding]; other site
449447000417	DNA binding site [nucleotide binding]
449447000418	sequence specific DNA binding site [nucleotide binding]; other site
449447000419	putative cAMP binding site [chemical binding]; other site
449447000420	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
449447000421	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
449447000422	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000423	putative active site [active]
449447000424	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000425	putative active site [active]
449447000426	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
449447000427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447000428	Walker A motif; other site
449447000429	ATP binding site [chemical binding]; other site
449447000430	Walker B motif; other site
449447000431	Protein kinase domain; Region: Pkinase; pfam00069
449447000432	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447000433	active site
449447000434	ATP binding site [chemical binding]; other site
449447000435	substrate binding site [chemical binding]; other site
449447000436	activation loop (A-loop); other site
449447000437	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
449447000438	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
449447000439	active site
449447000440	Zn binding site [ion binding]; other site
449447000441	cytochrome c biogenesis protein; Region: ccsA; CHL00045
449447000442	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447000443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447000444	Walker A motif; other site
449447000445	ATP binding site [chemical binding]; other site
449447000446	Walker B motif; other site
449447000447	arginine finger; other site
449447000448	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447000449	NIL domain; Region: NIL; pfam09383
449447000450	4Fe-4S binding domain; Region: Fer4; pfam00037
449447000451	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
449447000452	chorismate binding enzyme; Region: Chorismate_bind; cl10555
449447000453	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
449447000454	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
449447000455	NAD(P) binding site [chemical binding]; other site
449447000456	catalytic residues [active]
449447000457	Bacterial Ig-like domain; Region: Big_5; pfam13205
449447000458	TIGR03943 family protein; Region: TIGR03943
449447000459	Predicted permeases [General function prediction only]; Region: COG0701
449447000460	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
449447000461	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
449447000462	Ligand Binding Site [chemical binding]; other site
449447000463	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447000464	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447000465	XisI protein; Region: XisI; pfam08869
449447000466	XisH protein; Region: XisH; pfam08814
449447000467	argininosuccinate synthase; Provisional; Region: PRK13820
449447000468	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
449447000469	ANP binding site [chemical binding]; other site
449447000470	Substrate Binding Site II [chemical binding]; other site
449447000471	Substrate Binding Site I [chemical binding]; other site
449447000472	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
449447000473	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447000474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447000475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447000476	dimer interface [polypeptide binding]; other site
449447000477	phosphorylation site [posttranslational modification]
449447000478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447000479	ATP binding site [chemical binding]; other site
449447000480	Mg2+ binding site [ion binding]; other site
449447000481	G-X-G motif; other site
449447000482	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
449447000483	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
449447000484	ATP-grasp domain; Region: ATP-grasp; pfam02222
449447000485	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000486	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447000487	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000488	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
449447000489	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447000490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447000491	S-adenosylmethionine binding site [chemical binding]; other site
449447000492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447000493	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447000494	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
449447000495	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447000496	TM-ABC transporter signature motif; other site
449447000497	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
449447000498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
449447000499	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
449447000500	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
449447000501	high affinity sulphate transporter 1; Region: sulP; TIGR00815
449447000502	Sulfate transporter family; Region: Sulfate_transp; pfam00916
449447000503	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
449447000504	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447000505	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447000506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447000507	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447000508	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447000509	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000510	Probable transposase; Region: OrfB_IS605; pfam01385
449447000511	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447000512	Ion channel; Region: Ion_trans_2; pfam07885
449447000513	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
449447000514	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447000515	SNF2 Helicase protein; Region: DUF3670; pfam12419
449447000516	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
449447000517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000518	ATP binding site [chemical binding]; other site
449447000519	putative Mg++ binding site [ion binding]; other site
449447000520	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000521	nucleotide binding region [chemical binding]; other site
449447000522	ATP-binding site [chemical binding]; other site
449447000523	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000524	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447000525	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000526	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000528	TPR repeat; Region: TPR_11; pfam13414
449447000529	binding surface
449447000530	TPR motif; other site
449447000531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447000532	dimerization interface [polypeptide binding]; other site
449447000533	putative DNA binding site [nucleotide binding]; other site
449447000534	putative Zn2+ binding site [ion binding]; other site
449447000535	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000536	putative active site [active]
449447000537	PemK-like protein; Region: PemK; pfam02452
449447000538	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
449447000539	recombination protein F; Reviewed; Region: recF; PRK00064
449447000540	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
449447000541	Walker A/P-loop; other site
449447000542	ATP binding site [chemical binding]; other site
449447000543	Q-loop/lid; other site
449447000544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447000545	ABC transporter signature motif; other site
449447000546	Walker B; other site
449447000547	D-loop; other site
449447000548	H-loop/switch region; other site
449447000549	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
449447000550	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447000551	active site
449447000552	dimer interface [polypeptide binding]; other site
449447000553	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
449447000554	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
449447000555	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
449447000556	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447000557	Ligand Binding Site [chemical binding]; other site
449447000558	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
449447000559	Low molecular weight phosphatase family; Region: LMWPc; cd00115
449447000560	active site
449447000561	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
449447000562	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
449447000563	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
449447000564	arsenical-resistance protein; Region: acr3; TIGR00832
449447000565	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447000566	dimerization interface [polypeptide binding]; other site
449447000567	putative DNA binding site [nucleotide binding]; other site
449447000568	putative Zn2+ binding site [ion binding]; other site
449447000569	hypothetical protein; Provisional; Region: PRK13686
449447000570	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447000571	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447000572	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447000573	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447000574	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447000575	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447000576	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447000577	phosphoenolpyruvate synthase; Validated; Region: PRK06464
449447000578	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447000579	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
449447000580	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
449447000581	GUN4-like; Region: GUN4; pfam05419
449447000582	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
449447000583	putative active site [active]
449447000584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447000585	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447000586	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
449447000587	active site
449447000588	SAM binding site [chemical binding]; other site
449447000589	putative homodimer interface [polypeptide binding]; other site
449447000590	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
449447000591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447000592	S-adenosylmethionine binding site [chemical binding]; other site
449447000593	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567
449447000594	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447000595	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
449447000596	Precorrin-8X methylmutase; Region: CbiC; pfam02570
449447000597	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
449447000598	active site
449447000599	SAM binding site [chemical binding]; other site
449447000600	homodimer interface [polypeptide binding]; other site
449447000601	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
449447000602	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447000603	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447000604	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
449447000605	DNA protecting protein DprA; Region: dprA; TIGR00732
449447000606	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447000607	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447000608	catalytic residues [active]
449447000609	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
449447000610	propionate/acetate kinase; Provisional; Region: PRK12379
449447000611	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
449447000612	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447000613	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447000614	DNA binding residues [nucleotide binding]
449447000615	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
449447000616	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
449447000617	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
449447000618	active site
449447000619	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
449447000620	protein binding site [polypeptide binding]; other site
449447000621	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
449447000622	putative substrate binding region [chemical binding]; other site
449447000623	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
449447000624	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
449447000625	minor groove reading motif; other site
449447000626	helix-hairpin-helix signature motif; other site
449447000627	substrate binding pocket [chemical binding]; other site
449447000628	active site
449447000629	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
449447000630	Rhomboid family; Region: Rhomboid; cl11446
449447000631	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
449447000632	Predicted flavoprotein [General function prediction only]; Region: COG0431
449447000633	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
449447000634	homooctamer interface [polypeptide binding]; other site
449447000635	active site
449447000636	Homeodomain-like domain; Region: HTH_23; pfam13384
449447000637	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000638	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000639	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000640	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
449447000641	nickel binding site [ion binding]; other site
449447000642	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000643	putative active site [active]
449447000644	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000645	putative active site [active]
449447000646	Transcriptional regulator [Transcription]; Region: LytR; COG1316
449447000647	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
449447000648	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
449447000649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447000650	Coenzyme A binding pocket [chemical binding]; other site
449447000651	muropeptide transporter; Validated; Region: ampG; cl17669
449447000652	GAF domain; Region: GAF_3; pfam13492
449447000653	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
449447000654	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
449447000655	Probable transposase; Region: OrfB_IS605; pfam01385
449447000656	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000658	Probable transposase; Region: OrfB_IS605; pfam01385
449447000659	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
449447000660	dimer interface [polypeptide binding]; other site
449447000661	FMN binding site [chemical binding]; other site
449447000662	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
449447000663	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
449447000664	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
449447000665	DNA binding residues [nucleotide binding]
449447000666	dimer interface [polypeptide binding]; other site
449447000667	CpeS-like protein; Region: CpeS; pfam09367
449447000668	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447000669	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447000670	Ligand binding site; other site
449447000671	Putative Catalytic site; other site
449447000672	DXD motif; other site
449447000673	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447000674	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
449447000675	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447000676	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
449447000677	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
449447000678	NADP-binding site; other site
449447000679	homotetramer interface [polypeptide binding]; other site
449447000680	substrate binding site [chemical binding]; other site
449447000681	homodimer interface [polypeptide binding]; other site
449447000682	active site
449447000683	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447000684	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447000685	active site
449447000686	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
449447000687	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447000688	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
449447000689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447000690	NAD(P) binding site [chemical binding]; other site
449447000691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447000692	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447000693	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
449447000694	active site
449447000695	metal binding site [ion binding]; metal-binding site
449447000696	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
449447000697	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
449447000698	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
449447000699	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447000700	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447000701	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447000702	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
449447000703	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
449447000704	Homeodomain-like domain; Region: HTH_23; pfam13384
449447000705	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000706	Winged helix-turn helix; Region: HTH_33; pfam13592
449447000707	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000709	Probable transposase; Region: OrfB_IS605; pfam01385
449447000710	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447000711	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
449447000712	SNF2 Helicase protein; Region: DUF3670; pfam12419
449447000713	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447000714	ATP binding site [chemical binding]; other site
449447000715	putative Mg++ binding site [ion binding]; other site
449447000716	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447000717	nucleotide binding region [chemical binding]; other site
449447000718	ATP-binding site [chemical binding]; other site
449447000719	Uncharacterized conserved protein [Function unknown]; Region: COG4279
449447000720	SWIM zinc finger; Region: SWIM; pfam04434
449447000721	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447000722	TrkA-N domain; Region: TrkA_N; pfam02254
449447000723	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447000724	TrkA-N domain; Region: TrkA_N; pfam02254
449447000725	TrkA-C domain; Region: TrkA_C; pfam02080
449447000726	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
449447000727	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
449447000728	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
449447000729	ring oligomerisation interface [polypeptide binding]; other site
449447000730	ATP/Mg binding site [chemical binding]; other site
449447000731	stacking interactions; other site
449447000732	hinge regions; other site
449447000733	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
449447000734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447000735	Walker A/P-loop; other site
449447000736	ATP binding site [chemical binding]; other site
449447000737	Q-loop/lid; other site
449447000738	ABC transporter signature motif; other site
449447000739	Walker B; other site
449447000740	D-loop; other site
449447000741	H-loop/switch region; other site
449447000742	ABC transporter; Region: ABC_tran_2; pfam12848
449447000743	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
449447000744	Calx-beta domain; Region: Calx-beta; cl02522
449447000745	Calx-beta domain; Region: Calx-beta; cl02522
449447000746	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447000747	putative active site [active]
449447000748	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447000749	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
449447000750	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
449447000751	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447000752	HSP70 interaction site [polypeptide binding]; other site
449447000753	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
449447000754	Protein of unknown function (DUF565); Region: DUF565; pfam04483
449447000755	TPR repeat; Region: TPR_11; pfam13414
449447000756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000757	binding surface
449447000758	TPR motif; other site
449447000759	TPR repeat; Region: TPR_11; pfam13414
449447000760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000761	binding surface
449447000762	TPR motif; other site
449447000763	TPR repeat; Region: TPR_11; pfam13414
449447000764	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000765	binding surface
449447000766	TPR motif; other site
449447000767	TPR repeat; Region: TPR_11; pfam13414
449447000768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000769	binding surface
449447000770	TPR motif; other site
449447000771	TPR repeat; Region: TPR_11; pfam13414
449447000772	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447000773	putative active site [active]
449447000774	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447000775	Protein of unknown function (Ytp1); Region: Ytp1; pfam10355
449447000776	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447000777	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447000778	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447000779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000780	TPR repeat; Region: TPR_11; pfam13414
449447000781	binding surface
449447000782	TPR motif; other site
449447000783	TPR repeat; Region: TPR_11; pfam13414
449447000784	TPR repeat; Region: TPR_11; pfam13414
449447000785	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000786	binding surface
449447000787	TPR motif; other site
449447000788	TPR repeat; Region: TPR_11; pfam13414
449447000789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000790	binding surface
449447000791	TPR motif; other site
449447000792	TPR repeat; Region: TPR_11; pfam13414
449447000793	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447000794	Tetratricopeptide repeat; Region: TPR_1; pfam00515
449447000795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000796	binding surface
449447000797	TPR motif; other site
449447000798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000799	binding surface
449447000800	TPR motif; other site
449447000801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000802	binding surface
449447000803	TPR motif; other site
449447000804	TPR repeat; Region: TPR_11; pfam13414
449447000805	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447000806	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447000807	TPR repeat; Region: TPR_11; pfam13414
449447000808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000809	binding surface
449447000810	TPR motif; other site
449447000811	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447000812	putative active site [active]
449447000813	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447000814	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447000815	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447000816	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447000817	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447000818	Protein of unknown function DUF86; Region: DUF86; cl01031
449447000819	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447000820	active site
449447000821	NTP binding site [chemical binding]; other site
449447000822	metal binding triad [ion binding]; metal-binding site
449447000823	antibiotic binding site [chemical binding]; other site
449447000824	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447000825	YcfA-like protein; Region: YcfA; pfam07927
449447000826	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447000827	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447000828	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447000829	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000830	TPR motif; other site
449447000831	binding surface
449447000832	TPR repeat; Region: TPR_11; pfam13414
449447000833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000834	binding surface
449447000835	TPR motif; other site
449447000836	TPR repeat; Region: TPR_11; pfam13414
449447000837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000838	binding surface
449447000839	TPR motif; other site
449447000840	TPR repeat; Region: TPR_11; pfam13414
449447000841	Tetratricopeptide repeat; Region: TPR_1; pfam00515
449447000842	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447000843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000844	binding surface
449447000845	TPR motif; other site
449447000846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000847	binding surface
449447000848	TPR motif; other site
449447000849	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447000850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000851	binding surface
449447000852	TPR motif; other site
449447000853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000854	binding surface
449447000855	TPR motif; other site
449447000856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000857	binding surface
449447000858	TPR motif; other site
449447000859	TPR repeat; Region: TPR_11; pfam13414
449447000860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447000861	binding surface
449447000862	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447000863	TPR motif; other site
449447000864	CHAT domain; Region: CHAT; cl17868
449447000865	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
449447000866	CHASE2 domain; Region: CHASE2; pfam05226
449447000867	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447000868	FtsH Extracellular; Region: FtsH_ext; pfam06480
449447000869	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447000870	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447000871	Walker A motif; other site
449447000872	ATP binding site [chemical binding]; other site
449447000873	Walker B motif; other site
449447000874	arginine finger; other site
449447000875	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447000876	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
449447000877	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
449447000878	Predicted membrane protein [Function unknown]; Region: COG3463
449447000879	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
449447000880	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447000881	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447000882	substrate binding pocket [chemical binding]; other site
449447000883	membrane-bound complex binding site; other site
449447000884	hinge residues; other site
449447000885	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447000886	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447000887	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447000888	HSP70 interaction site [polypeptide binding]; other site
449447000889	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447000890	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000891	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447000892	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447000893	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447000894	Magnesium ion binding site [ion binding]; other site
449447000895	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
449447000896	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
449447000897	GatB domain; Region: GatB_Yqey; smart00845
449447000898	pyruvate kinase; Validated; Region: PRK08187
449447000899	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
449447000900	domain interfaces; other site
449447000901	active site
449447000902	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
449447000903	Methyltransferase domain; Region: Methyltransf_24; pfam13578
449447000904	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447000905	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
449447000906	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
449447000907	G-X-X-G motif; other site
449447000908	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
449447000909	RxxxH motif; other site
449447000910	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
449447000911	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
449447000912	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
449447000913	Bacterial PH domain; Region: DUF304; pfam03703
449447000914	ribonuclease P; Reviewed; Region: rnpA; PRK03031
449447000915	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
449447000916	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
449447000917	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
449447000918	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
449447000919	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
449447000920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447000921	motif II; other site
449447000922	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
449447000923	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
449447000924	dimer interface [polypeptide binding]; other site
449447000925	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
449447000926	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
449447000927	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
449447000928	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
449447000929	Walker A motif; other site
449447000930	ATP binding site [chemical binding]; other site
449447000931	Walker B motif; other site
449447000932	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
449447000933	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447000934	Walker A motif; other site
449447000935	ATP binding site [chemical binding]; other site
449447000936	Walker B motif; other site
449447000937	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
449447000938	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
449447000939	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
449447000940	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
449447000941	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447000942	FeS/SAM binding site; other site
449447000943	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
449447000944	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
449447000945	Homeodomain-like domain; Region: HTH_23; pfam13384
449447000946	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000947	Homeodomain-like domain; Region: HTH_32; pfam13565
449447000948	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000949	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447000950	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447000951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
449447000952	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447000953	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447000954	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000955	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000956	PIN domain; Region: PIN_3; cl17397
449447000957	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447000958	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000959	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447000960	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447000961	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447000962	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447000963	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447000964	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447000965	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447000966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447000967	Paired Box domain; Region: PAX; cd00131
449447000968	DNA binding site [nucleotide binding]
449447000969	Winged helix-turn helix; Region: HTH_29; pfam13551
449447000970	Homeodomain-like domain; Region: HTH_32; pfam13565
449447000971	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
449447000972	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
449447000973	putative dimer interface [polypeptide binding]; other site
449447000974	putative anticodon binding site; other site
449447000975	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
449447000976	homodimer interface [polypeptide binding]; other site
449447000977	motif 1; other site
449447000978	motif 2; other site
449447000979	active site
449447000980	motif 3; other site
449447000981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447000982	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447000983	Probable transposase; Region: OrfB_IS605; pfam01385
449447000984	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447000985	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
449447000986	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447000987	DNA gyrase subunit A; Validated; Region: PRK05560
449447000988	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
449447000989	CAP-like domain; other site
449447000990	active site
449447000991	primary dimer interface [polypeptide binding]; other site
449447000992	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000993	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000994	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000995	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000996	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000997	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447000998	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
449447000999	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447001000	cofactor binding site; other site
449447001001	DNA binding site [nucleotide binding]
449447001002	substrate interaction site [chemical binding]; other site
449447001003	ICEA Protein; Region: ICEA; pfam05315
449447001004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
449447001005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447001006	non-specific DNA binding site [nucleotide binding]; other site
449447001007	salt bridge; other site
449447001008	sequence-specific DNA binding site [nucleotide binding]; other site
449447001009	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
449447001010	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
449447001011	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447001012	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
449447001013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001014	S-adenosylmethionine binding site [chemical binding]; other site
449447001015	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
449447001016	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
449447001017	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447001018	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001019	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447001020	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447001021	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447001022	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
449447001023	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
449447001024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001025	FeS/SAM binding site; other site
449447001026	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
449447001027	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
449447001028	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001029	putative active site [active]
449447001030	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001031	putative active site [active]
449447001032	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
449447001033	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
449447001034	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
449447001035	P loop; other site
449447001036	GTP binding site [chemical binding]; other site
449447001037	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
449447001038	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
449447001039	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
449447001040	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
449447001041	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
449447001042	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001043	putative active site [active]
449447001044	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001045	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001046	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001047	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
449447001048	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001049	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447001050	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447001051	Homeodomain-like domain; Region: HTH_32; pfam13565
449447001052	Integrase core domain; Region: rve; pfam00665
449447001053	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001054	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447001055	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447001056	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001057	putative active site [active]
449447001058	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001059	Domain of unknown function (DUF927); Region: DUF927; cl12098
449447001060	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001061	catalytic core [active]
449447001062	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
449447001063	DHH family; Region: DHH; pfam01368
449447001064	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001065	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001066	Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672
449447001067	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001068	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001069	HsdM N-terminal domain; Region: HsdM_N; pfam12161
449447001070	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447001071	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
449447001072	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
449447001073	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
449447001074	putative active site [active]
449447001075	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
449447001076	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447001077	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
449447001078	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
449447001079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
449447001080	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001081	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001082	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447001083	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447001084	Homeodomain-like domain; Region: HTH_23; pfam13384
449447001085	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001086	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001087	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001088	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
449447001089	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447001090	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001091	putative active site [active]
449447001092	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001093	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001094	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001095	putative active site [active]
449447001096	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001097	putative active site [active]
449447001098	citrate synthase; Provisional; Region: PRK14036
449447001099	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
449447001100	oxalacetate binding site [chemical binding]; other site
449447001101	citrylCoA binding site [chemical binding]; other site
449447001102	coenzyme A binding site [chemical binding]; other site
449447001103	catalytic triad [active]
449447001104	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
449447001105	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
449447001106	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
449447001107	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
449447001108	active site
449447001109	TDP-binding site; other site
449447001110	acceptor substrate-binding pocket; other site
449447001111	homodimer interface [polypeptide binding]; other site
449447001112	Uncharacterized conserved protein [Function unknown]; Region: COG2442
449447001113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001114	Probable transposase; Region: OrfB_IS605; pfam01385
449447001115	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001116	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
449447001117	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
449447001118	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
449447001119	NAD binding site [chemical binding]; other site
449447001120	dimer interface [polypeptide binding]; other site
449447001121	substrate binding site [chemical binding]; other site
449447001122	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447001123	Protein of unknown function (DUF952); Region: DUF952; pfam06108
449447001124	cytosine deaminase-like protein; Validated; Region: PRK07583
449447001125	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
449447001126	active site
449447001127	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
449447001128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001129	FeS/SAM binding site; other site
449447001130	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447001131	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447001132	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
449447001133	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
449447001134	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
449447001135	putative active site [active]
449447001136	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
449447001137	putative active site [active]
449447001138	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
449447001139	catalytic center binding site [active]
449447001140	ATP binding site [chemical binding]; other site
449447001141	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
449447001142	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447001143	G1 box; other site
449447001144	GTP/Mg2+ binding site [chemical binding]; other site
449447001145	Switch I region; other site
449447001146	G2 box; other site
449447001147	Switch II region; other site
449447001148	G3 box; other site
449447001149	G4 box; other site
449447001150	G5 box; other site
449447001151	Domain of unknown function (DUF697); Region: DUF697; pfam05128
449447001152	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
449447001153	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
449447001154	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
449447001155	Predicted ATPases [General function prediction only]; Region: COG1106
449447001156	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447001157	Walker A/P-loop; other site
449447001158	ATP binding site [chemical binding]; other site
449447001159	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447001160	L-asparaginase II; Region: Asparaginase_II; cl01842
449447001161	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
449447001162	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
449447001163	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
449447001164	Zn2+ binding site [ion binding]; other site
449447001165	Mg2+ binding site [ion binding]; other site
449447001166	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
449447001167	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447001168	G1 box; other site
449447001169	GTP/Mg2+ binding site [chemical binding]; other site
449447001170	Switch I region; other site
449447001171	G2 box; other site
449447001172	Switch II region; other site
449447001173	G3 box; other site
449447001174	G4 box; other site
449447001175	G5 box; other site
449447001176	Domain of unknown function (DUF697); Region: DUF697; pfam05128
449447001177	Probable transposase; Region: OrfB_IS605; pfam01385
449447001178	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001179	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447001180	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
449447001181	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
449447001182	alpha subunit interface [polypeptide binding]; other site
449447001183	TPP binding site [chemical binding]; other site
449447001184	heterodimer interface [polypeptide binding]; other site
449447001185	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447001186	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
449447001187	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
449447001188	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
449447001189	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
449447001190	Protein export membrane protein; Region: SecD_SecF; pfam02355
449447001191	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447001192	DDE superfamily endonuclease; Region: DDE_5; pfam13546
449447001193	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001194	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447001195	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447001196	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447001197	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447001198	putative active site [active]
449447001199	putative NTP binding site [chemical binding]; other site
449447001200	putative nucleic acid binding site [nucleotide binding]; other site
449447001201	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447001202	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447001203	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447001204	active site
449447001205	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
449447001206	active site
449447001207	putative DNA-binding cleft [nucleotide binding]; other site
449447001208	dimer interface [polypeptide binding]; other site
449447001209	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
449447001210	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
449447001211	active site
449447001212	homodimer interface [polypeptide binding]; other site
449447001213	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
449447001214	mce related protein; Region: MCE; pfam02470
449447001215	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
449447001216	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
449447001217	Walker A/P-loop; other site
449447001218	ATP binding site [chemical binding]; other site
449447001219	Q-loop/lid; other site
449447001220	ABC transporter signature motif; other site
449447001221	Walker B; other site
449447001222	D-loop; other site
449447001223	H-loop/switch region; other site
449447001224	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
449447001225	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447001226	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001227	catalytic core [active]
449447001228	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447001229	catalytic core [active]
449447001230	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
449447001231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
449447001232	acetolactate synthase; Reviewed; Region: PRK08322
449447001233	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
449447001234	PYR/PP interface [polypeptide binding]; other site
449447001235	dimer interface [polypeptide binding]; other site
449447001236	TPP binding site [chemical binding]; other site
449447001237	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
449447001238	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
449447001239	TPP-binding site [chemical binding]; other site
449447001240	dimer interface [polypeptide binding]; other site
449447001241	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001242	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
449447001243	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
449447001244	Probable Catalytic site; other site
449447001245	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
449447001246	S-layer homology domain; Region: SLH; pfam00395
449447001247	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447001248	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
449447001249	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
449447001250	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
449447001251	catalytic triad [active]
449447001252	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001253	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001254	Homeodomain-like domain; Region: HTH_23; pfam13384
449447001255	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001256	Homeodomain-like domain; Region: HTH_32; pfam13565
449447001257	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001258	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
449447001259	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
449447001260	active site
449447001261	substrate-binding site [chemical binding]; other site
449447001262	metal-binding site [ion binding]
449447001263	ATP binding site [chemical binding]; other site
449447001264	flavoprotein, HI0933 family; Region: TIGR00275
449447001265	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447001266	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
449447001267	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
449447001268	Walker A/P-loop; other site
449447001269	ATP binding site [chemical binding]; other site
449447001270	Q-loop/lid; other site
449447001271	ABC transporter signature motif; other site
449447001272	Walker B; other site
449447001273	D-loop; other site
449447001274	H-loop/switch region; other site
449447001275	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
449447001276	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
449447001277	Walker A/P-loop; other site
449447001278	ATP binding site [chemical binding]; other site
449447001279	Q-loop/lid; other site
449447001280	ABC transporter signature motif; other site
449447001281	Walker B; other site
449447001282	D-loop; other site
449447001283	H-loop/switch region; other site
449447001284	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447001285	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
449447001286	TM-ABC transporter signature motif; other site
449447001287	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447001288	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
449447001289	TM-ABC transporter signature motif; other site
449447001290	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
449447001291	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
449447001292	putative ligand binding site [chemical binding]; other site
449447001293	Predicted membrane protein [Function unknown]; Region: COG2119
449447001294	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
449447001295	Predicted membrane protein [Function unknown]; Region: COG2119
449447001296	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
449447001297	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
449447001298	metal ion-dependent adhesion site (MIDAS); other site
449447001299	glycogen synthase; Provisional; Region: glgA; PRK00654
449447001300	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
449447001301	ADP-binding pocket [chemical binding]; other site
449447001302	homodimer interface [polypeptide binding]; other site
449447001303	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
449447001304	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
449447001305	16S/18S rRNA binding site [nucleotide binding]; other site
449447001306	S13e-L30e interaction site [polypeptide binding]; other site
449447001307	25S rRNA binding site [nucleotide binding]; other site
449447001308	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
449447001309	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
449447001310	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
449447001311	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001312	putative active site [active]
449447001313	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001314	putative active site [active]
449447001315	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
449447001316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447001317	Dienelactone hydrolase family; Region: DLH; pfam01738
449447001318	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
449447001319	30S ribosomal protein S1; Reviewed; Region: PRK07400
449447001320	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
449447001321	RNA binding site [nucleotide binding]; other site
449447001322	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
449447001323	RNA binding site [nucleotide binding]; other site
449447001324	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
449447001325	RNA binding site [nucleotide binding]; other site
449447001326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001327	S-adenosylmethionine binding site [chemical binding]; other site
449447001328	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
449447001329	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
449447001330	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447001331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001332	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447001333	Protein of unknown function (DUF760); Region: DUF760; pfam05542
449447001334	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
449447001335	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
449447001336	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
449447001337	active site
449447001338	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
449447001339	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
449447001340	Walker A/P-loop; other site
449447001341	ATP binding site [chemical binding]; other site
449447001342	Q-loop/lid; other site
449447001343	ABC transporter signature motif; other site
449447001344	Walker B; other site
449447001345	D-loop; other site
449447001346	H-loop/switch region; other site
449447001347	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001348	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447001349	Transposase domain (DUF772); Region: DUF772; pfam05598
449447001350	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001351	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001352	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
449447001353	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447001354	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
449447001355	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
449447001356	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447001357	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447001358	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
449447001359	YcfA-like protein; Region: YcfA; cl00752
449447001360	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447001361	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
449447001362	hydrophobic ligand binding site; other site
449447001363	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
449447001364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
449447001365	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
449447001366	UbiA prenyltransferase family; Region: UbiA; pfam01040
449447001367	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
449447001368	Family description; Region: UvrD_C_2; pfam13538
449447001369	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
449447001370	Ligand Binding Site [chemical binding]; other site
449447001371	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
449447001372	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
449447001373	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
449447001374	Ion transport protein; Region: Ion_trans; pfam00520
449447001375	Ion channel; Region: Ion_trans_2; pfam07885
449447001376	Double zinc ribbon; Region: DZR; pfam12773
449447001377	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447001378	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
449447001379	ATP-NAD kinase; Region: NAD_kinase; pfam01513
449447001380	Ycf39; Provisional; Region: ycf39; CHL00194
449447001381	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
449447001382	NAD(P) binding site [chemical binding]; other site
449447001383	putative active site [active]
449447001384	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
449447001385	dimer interface [polypeptide binding]; other site
449447001386	catalytic triad [active]
449447001387	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447001388	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447001389	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
449447001390	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
449447001391	dihydropteroate synthase; Region: DHPS; TIGR01496
449447001392	substrate binding pocket [chemical binding]; other site
449447001393	dimer interface [polypeptide binding]; other site
449447001394	inhibitor binding site; inhibition site
449447001395	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
449447001396	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
449447001397	active site
449447001398	(T/H)XGH motif; other site
449447001399	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
449447001400	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447001401	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447001402	catalytic residues [active]
449447001403	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
449447001404	methionine aminopeptidase; Provisional; Region: PRK08671
449447001405	active site
449447001406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447001407	Ligand Binding Site [chemical binding]; other site
449447001408	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
449447001409	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
449447001410	putative active site [active]
449447001411	catalytic residue [active]
449447001412	VPS10 domain; Region: VPS10; smart00602
449447001413	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
449447001414	fumarate hydratase; Reviewed; Region: fumC; PRK00485
449447001415	Class II fumarases; Region: Fumarase_classII; cd01362
449447001416	active site
449447001417	tetramer interface [polypeptide binding]; other site
449447001418	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
449447001419	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
449447001420	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447001421	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447001422	PIN domain; Region: PIN_2; pfam10130
449447001423	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
449447001424	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
449447001425	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
449447001426	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
449447001427	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447001428	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
449447001429	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
449447001430	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
449447001431	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
449447001432	AAA domain; Region: AAA_31; pfam13614
449447001433	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447001434	P-loop; other site
449447001435	Magnesium ion binding site [ion binding]; other site
449447001436	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447001437	Magnesium ion binding site [ion binding]; other site
449447001438	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
449447001439	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001440	putative active site [active]
449447001441	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001442	putative active site [active]
449447001443	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
449447001444	DNA photolyase; Region: DNA_photolyase; pfam00875
449447001445	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447001446	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447001447	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447001448	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
449447001449	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
449447001450	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
449447001451	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
449447001452	GIY-YIG motif/motif A; other site
449447001453	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001454	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001455	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
449447001456	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
449447001457	glutathione synthetase; Provisional; Region: PRK05246
449447001458	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
449447001459	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
449447001460	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
449447001461	GSH binding site [chemical binding]; other site
449447001462	catalytic residues [active]
449447001463	YGGT family; Region: YGGT; pfam02325
449447001464	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
449447001465	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
449447001466	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
449447001467	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447001468	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
449447001469	putative catalytic site [active]
449447001470	putative phosphate binding site [ion binding]; other site
449447001471	active site
449447001472	metal binding site A [ion binding]; metal-binding site
449447001473	DNA binding site [nucleotide binding]
449447001474	putative AP binding site [nucleotide binding]; other site
449447001475	putative metal binding site B [ion binding]; other site
449447001476	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
449447001477	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447001478	putative di-iron ligands [ion binding]; other site
449447001479	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447001480	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
449447001481	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447001482	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447001483	DNA-binding interface [nucleotide binding]; DNA binding site
449447001484	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001485	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001486	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001487	Homeodomain-like domain; Region: HTH_23; pfam13384
449447001488	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001489	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001490	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001491	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447001492	Transposase domain (DUF772); Region: DUF772; pfam05598
449447001493	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
449447001494	putative active site [active]
449447001495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447001496	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
449447001497	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
449447001498	active site
449447001499	dimer interface [polypeptide binding]; other site
449447001500	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
449447001501	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
449447001502	active site
449447001503	FMN binding site [chemical binding]; other site
449447001504	substrate binding site [chemical binding]; other site
449447001505	3Fe-4S cluster binding site [ion binding]; other site
449447001506	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
449447001507	domain interface; other site
449447001508	TIGR04255 family protein; Region: sporadTIGR04255
449447001509	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
449447001510	PIN domain; Region: PIN_3; cl17397
449447001511	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
449447001512	hypothetical protein; Region: PHA00733
449447001513	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447001514	putative active site [active]
449447001515	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447001516	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
449447001517	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447001518	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
449447001519	nucleophilic elbow; other site
449447001520	catalytic triad; other site
449447001521	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
449447001522	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
449447001523	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447001524	Sporulation and spore germination; Region: Germane; pfam10646
449447001525	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447001526	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
449447001527	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
449447001528	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
449447001529	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001530	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001531	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001532	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001533	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001534	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447001535	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447001536	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
449447001537	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
449447001538	Malic enzyme, N-terminal domain; Region: malic; pfam00390
449447001539	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
449447001540	putative NAD(P) binding site [chemical binding]; other site
449447001541	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
449447001542	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
449447001543	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447001544	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
449447001545	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447001546	protein binding surface [polypeptide binding]; other site
449447001547	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
449447001548	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
449447001549	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
449447001550	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
449447001551	protein binding surface [polypeptide binding]; other site
449447001552	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
449447001553	protein binding surface [polypeptide binding]; other site
449447001554	HEAT-like repeat; Region: HEAT_EZ; pfam13513
449447001555	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001556	TIR domain; Region: TIR_2; pfam13676
449447001557	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447001558	HEAT repeats; Region: HEAT_2; pfam13646
449447001559	HEAT repeats; Region: HEAT_2; pfam13646
449447001560	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
449447001561	HEAT repeats; Region: HEAT_2; pfam13646
449447001562	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
449447001563	Lipase (class 2); Region: Lipase_2; pfam01674
449447001564	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447001565	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
449447001566	Peptidase family M50; Region: Peptidase_M50; pfam02163
449447001567	active site
449447001568	putative substrate binding region [chemical binding]; other site
449447001569	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
449447001570	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
449447001571	putative active site [active]
449447001572	ribosomal protein L21; Region: rpl21; CHL00075
449447001573	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
449447001574	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
449447001575	Uncharacterized conserved protein [Function unknown]; Region: COG2361
449447001576	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447001577	active site
449447001578	NTP binding site [chemical binding]; other site
449447001579	metal binding triad [ion binding]; metal-binding site
449447001580	antibiotic binding site [chemical binding]; other site
449447001581	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
449447001582	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
449447001583	spermine synthase; Region: PLN02823
449447001584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001585	S-adenosylmethionine binding site [chemical binding]; other site
449447001586	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
449447001587	DHH family; Region: DHH; pfam01368
449447001588	DHHA1 domain; Region: DHHA1; pfam02272
449447001589	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
449447001590	MoaE interaction surface [polypeptide binding]; other site
449447001591	MoeB interaction surface [polypeptide binding]; other site
449447001592	thiocarboxylated glycine; other site
449447001593	exonuclease SbcC; Region: sbcc; TIGR00618
449447001594	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
449447001595	Walker A/P-loop; other site
449447001596	ATP binding site [chemical binding]; other site
449447001597	Q-loop/lid; other site
449447001598	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447001599	ABC transporter signature motif; other site
449447001600	Walker B; other site
449447001601	D-loop; other site
449447001602	H-loop/switch region; other site
449447001603	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447001604	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
449447001605	active site residue [active]
449447001606	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
449447001607	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001608	Homeodomain-like domain; Region: HTH_32; pfam13565
449447001609	Predicted helicase [General function prediction only]; Region: COG4889
449447001610	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447001611	lipoyl synthase; Provisional; Region: PRK05481
449447001612	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001613	FeS/SAM binding site; other site
449447001614	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
449447001615	active site
449447001616	dimerization interface [polypeptide binding]; other site
449447001617	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
449447001618	MoaE homodimer interface [polypeptide binding]; other site
449447001619	MoaD interaction [polypeptide binding]; other site
449447001620	active site residues [active]
449447001621	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447001622	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
449447001623	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001624	FeS/SAM binding site; other site
449447001625	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447001626	putative high light inducible protein; Region: PHA02337
449447001627	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
449447001628	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
449447001629	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
449447001630	NAD(P) binding site [chemical binding]; other site
449447001631	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
449447001632	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447001633	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447001634	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447001635	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447001636	motif II; other site
449447001637	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447001638	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
449447001639	active site
449447001640	substrate binding pocket [chemical binding]; other site
449447001641	dimer interface [polypeptide binding]; other site
449447001642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447001643	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447001644	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447001645	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447001646	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447001647	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447001648	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
449447001649	Restriction endonuclease; Region: Mrr_cat; pfam04471
449447001650	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447001651	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447001652	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447001653	putative active site [active]
449447001654	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
449447001655	CAAX protease self-immunity; Region: Abi; pfam02517
449447001656	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
449447001657	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
449447001658	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
449447001659	Protein of unknown function, DUF608; Region: DUF608; pfam04685
449447001660	Protein of unknown function (DUF563); Region: DUF563; pfam04577
449447001661	putative oxidoreductase; Provisional; Region: PRK12831
449447001662	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
449447001663	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
449447001664	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
449447001665	iron-sulfur cluster [ion binding]; other site
449447001666	[2Fe-2S] cluster binding site [ion binding]; other site
449447001667	Pheophorbide a oxygenase; Region: PaO; pfam08417
449447001668	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
449447001669	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
449447001670	active site
449447001671	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
449447001672	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
449447001673	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
449447001674	ABC-ATPase subunit  interface; other site
449447001675	dimer interface [polypeptide binding]; other site
449447001676	putative PBP binding regions; other site
449447001677	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
449447001678	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
449447001679	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
449447001680	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
449447001681	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
449447001682	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447001683	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447001684	Hexamer interface [polypeptide binding]; other site
449447001685	Hexagonal pore residue; other site
449447001686	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447001687	Hexamer interface [polypeptide binding]; other site
449447001688	Hexagonal pore residue; other site
449447001689	Restriction endonuclease EcoRI; Region: EcoRI; pfam02963
449447001690	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447001691	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447001692	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447001693	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447001694	PemK-like protein; Region: PemK; pfam02452
449447001695	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447001696	putative active site [active]
449447001697	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
449447001698	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
449447001699	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
449447001700	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
449447001701	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
449447001702	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
449447001703	Protein of unknown function (DUF98); Region: DUF98; pfam01947
449447001704	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
449447001705	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
449447001706	C-terminal domain interface [polypeptide binding]; other site
449447001707	GSH binding site (G-site) [chemical binding]; other site
449447001708	dimer interface [polypeptide binding]; other site
449447001709	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
449447001710	N-terminal domain interface [polypeptide binding]; other site
449447001711	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447001712	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447001713	Catalytic site [active]
449447001714	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
449447001715	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
449447001716	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
449447001717	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
449447001718	putative substrate binding site [chemical binding]; other site
449447001719	putative ATP binding site [chemical binding]; other site
449447001720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
449447001721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447001722	Coenzyme A binding pocket [chemical binding]; other site
449447001723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447001724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447001725	dimer interface [polypeptide binding]; other site
449447001726	phosphorylation site [posttranslational modification]
449447001727	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
449447001728	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001729	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001730	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447001731	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447001732	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447001733	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447001734	Ligand binding site; other site
449447001735	Putative Catalytic site; other site
449447001736	DXD motif; other site
449447001737	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
449447001738	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447001739	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
449447001740	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
449447001741	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
449447001742	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
449447001743	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447001744	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447001745	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447001746	YcfA-like protein; Region: YcfA; pfam07927
449447001747	RelB antitoxin; Region: RelB; cl01171
449447001748	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447001749	YcfA-like protein; Region: YcfA; pfam07927
449447001750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447001751	BT1 family; Region: BT1; pfam03092
449447001752	putative substrate translocation pore; other site
449447001753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001754	Probable transposase; Region: OrfB_IS605; pfam01385
449447001755	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447001756	Cadmium resistance transporter; Region: Cad; pfam03596
449447001757	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447001758	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447001759	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447001760	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265
449447001761	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
449447001762	Walker A/P-loop; other site
449447001763	ATP binding site [chemical binding]; other site
449447001764	Q-loop/lid; other site
449447001765	ABC transporter signature motif; other site
449447001766	Walker B; other site
449447001767	D-loop; other site
449447001768	H-loop/switch region; other site
449447001769	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
449447001770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447001771	dimer interface [polypeptide binding]; other site
449447001772	conserved gate region; other site
449447001773	putative PBP binding loops; other site
449447001774	ABC-ATPase subunit interface; other site
449447001775	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
449447001776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447001777	dimer interface [polypeptide binding]; other site
449447001778	conserved gate region; other site
449447001779	putative PBP binding loops; other site
449447001780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447001781	ABC-ATPase subunit interface; other site
449447001782	PBP superfamily domain; Region: PBP_like_2; cl17296
449447001783	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001784	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001785	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447001786	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
449447001787	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447001788	Cadmium resistance transporter; Region: Cad; pfam03596
449447001789	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447001790	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
449447001791	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447001792	substrate binding pocket [chemical binding]; other site
449447001793	membrane-bound complex binding site; other site
449447001794	hinge residues; other site
449447001795	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001796	Probable transposase; Region: OrfB_IS605; pfam01385
449447001797	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001798	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447001799	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447001800	DNA binding residues [nucleotide binding]
449447001801	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447001802	catalytic residues [active]
449447001803	catalytic nucleophile [active]
449447001804	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
449447001805	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447001806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447001807	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447001808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447001809	DNA binding residues [nucleotide binding]
449447001810	hypothetical protein; Provisional; Region: PRK07394
449447001811	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
449447001812	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447001813	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447001814	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
449447001815	dimerization interface [polypeptide binding]; other site
449447001816	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
449447001817	putative catalytic site [active]
449447001818	putative metal binding site [ion binding]; other site
449447001819	putative phosphate binding site [ion binding]; other site
449447001820	CARDB; Region: CARDB; pfam07705
449447001821	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
449447001822	active site
449447001823	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
449447001824	Protein of unknown function, DUF393; Region: DUF393; pfam04134
449447001825	Integral membrane protein TerC family; Region: TerC; cl10468
449447001826	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
449447001827	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447001828	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447001829	DNA-binding interface [nucleotide binding]; DNA binding site
449447001830	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001831	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001832	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
449447001833	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
449447001834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
449447001835	malate dehydrogenase; Reviewed; Region: PRK06223
449447001836	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
449447001837	NAD(P) binding site [chemical binding]; other site
449447001838	dimer interface [polypeptide binding]; other site
449447001839	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447001840	substrate binding site [chemical binding]; other site
449447001841	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
449447001842	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
449447001843	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
449447001844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447001845	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447001846	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447001847	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
449447001848	peptide chain release factor 2; Provisional; Region: PRK05589
449447001849	This domain is found in peptide chain release factors; Region: PCRF; smart00937
449447001850	RF-1 domain; Region: RF-1; pfam00472
449447001851	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
449447001852	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
449447001853	Divergent AAA domain; Region: AAA_4; pfam04326
449447001854	ferrochelatase; Reviewed; Region: hemH; PRK00035
449447001855	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
449447001856	active site
449447001857	C-terminal domain interface [polypeptide binding]; other site
449447001858	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
449447001859	active site
449447001860	N-terminal domain interface [polypeptide binding]; other site
449447001861	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
449447001862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001863	S-adenosylmethionine binding site [chemical binding]; other site
449447001864	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
449447001865	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447001866	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001868	S-adenosylmethionine binding site [chemical binding]; other site
449447001869	ketol-acid reductoisomerase; Provisional; Region: PRK05479
449447001870	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
449447001871	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
449447001872	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
449447001873	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
449447001874	Secretin and TonB N terminus short domain; Region: STN; pfam07660
449447001875	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
449447001876	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
449447001877	Protein of unknown function (DUF751); Region: DUF751; pfam05421
449447001878	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
449447001879	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
449447001880	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
449447001881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
449447001882	conserved hypothetical protein; Region: TIGR03492
449447001883	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
449447001884	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
449447001885	amphipathic channel; other site
449447001886	Asn-Pro-Ala signature motifs; other site
449447001887	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447001888	Homeodomain-like domain; Region: HTH_23; pfam13384
449447001889	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001890	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001891	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001893	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001895	Paired Box domain; Region: PAX; cd00131
449447001896	DNA binding site [nucleotide binding]
449447001897	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001898	Homeodomain-like domain; Region: HTH_32; pfam13565
449447001899	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447001900	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447001901	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447001902	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447001903	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
449447001904	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447001905	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447001906	S-layer homology domain; Region: SLH; pfam00395
449447001907	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447001908	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447001909	Transposase domain (DUF772); Region: DUF772; pfam05598
449447001910	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
449447001911	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447001912	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
449447001913	HSP70 interaction site [polypeptide binding]; other site
449447001914	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
449447001915	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
449447001916	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447001917	FeS/SAM binding site; other site
449447001918	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
449447001919	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447001920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447001921	S-adenosylmethionine binding site [chemical binding]; other site
449447001922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
449447001923	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447001924	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447001925	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001926	Paired Box domain; Region: PAX; cd00131
449447001927	DNA binding site [nucleotide binding]
449447001928	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001929	Homeodomain-like domain; Region: HTH_32; pfam13565
449447001930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447001931	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447001932	Probable transposase; Region: OrfB_IS605; pfam01385
449447001933	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447001934	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447001935	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447001936	protein I interface; other site
449447001937	D2 interface; other site
449447001938	protein T interface; other site
449447001939	chlorophyll binding site; other site
449447001940	beta carotene binding site; other site
449447001941	pheophytin binding site; other site
449447001942	manganese-stabilizing polypeptide interface; other site
449447001943	CP43 interface; other site
449447001944	protein L interface; other site
449447001945	oxygen evolving complex binding site; other site
449447001946	bromide binding site; other site
449447001947	quinone binding site; other site
449447001948	Fe binding site [ion binding]; other site
449447001949	core light harvesting interface; other site
449447001950	cytochrome b559 alpha subunit interface; other site
449447001951	cytochrome c-550 interface; other site
449447001952	protein J interface; other site
449447001953	methionine sulfoxide reductase B; Provisional; Region: PRK00222
449447001954	SelR domain; Region: SelR; pfam01641
449447001955	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
449447001956	allophycocyanin beta subunit; Region: apcB; CHL00088
449447001957	Phycobilisome protein; Region: Phycobilisome; cl08227
449447001958	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
449447001959	RuvA N terminal domain; Region: RuvA_N; pfam01330
449447001960	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
449447001961	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
449447001962	Peptidase family M50; Region: Peptidase_M50; pfam02163
449447001963	active site
449447001964	putative substrate binding region [chemical binding]; other site
449447001965	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
449447001966	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
449447001967	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
449447001968	Homeodomain-like domain; Region: HTH_23; pfam13384
449447001969	Winged helix-turn helix; Region: HTH_29; pfam13551
449447001970	Winged helix-turn helix; Region: HTH_33; pfam13592
449447001971	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447001972	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447001973	proposed catalytic triad [active]
449447001974	active site nucleophile [active]
449447001975	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447001976	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
449447001977	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
449447001978	Na binding site [ion binding]; other site
449447001979	cyanate hydratase; Validated; Region: PRK02866
449447001980	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
449447001981	oligomer interface [polypeptide binding]; other site
449447001982	active site
449447001983	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447001984	protein I interface; other site
449447001985	D2 interface; other site
449447001986	protein T interface; other site
449447001987	chlorophyll binding site; other site
449447001988	beta carotene binding site; other site
449447001989	pheophytin binding site; other site
449447001990	manganese-stabilizing polypeptide interface; other site
449447001991	CP43 interface; other site
449447001992	protein L interface; other site
449447001993	oxygen evolving complex binding site; other site
449447001994	bromide binding site; other site
449447001995	quinone binding site; other site
449447001996	Fe binding site [ion binding]; other site
449447001997	core light harvesting interface; other site
449447001998	cytochrome b559 alpha subunit interface; other site
449447001999	cytochrome c-550 interface; other site
449447002000	protein J interface; other site
449447002001	PemK-like protein; Region: PemK; pfam02452
449447002002	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
449447002003	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447002004	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447002005	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002006	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002007	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002008	Paired Box domain; Region: PAX; cd00131
449447002009	DNA binding site [nucleotide binding]
449447002010	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002011	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002012	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447002014	AAA ATPase domain; Region: AAA_16; pfam13191
449447002015	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447002016	protein I interface; other site
449447002017	D2 interface; other site
449447002018	protein T interface; other site
449447002019	chlorophyll binding site; other site
449447002020	beta carotene binding site; other site
449447002021	pheophytin binding site; other site
449447002022	manganese-stabilizing polypeptide interface; other site
449447002023	CP43 interface; other site
449447002024	protein L interface; other site
449447002025	oxygen evolving complex binding site; other site
449447002026	bromide binding site; other site
449447002027	quinone binding site; other site
449447002028	Fe binding site [ion binding]; other site
449447002029	core light harvesting interface; other site
449447002030	cytochrome b559 alpha subunit interface; other site
449447002031	cytochrome c-550 interface; other site
449447002032	protein J interface; other site
449447002033	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002034	putative active site [active]
449447002035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
449447002036	Archaeal ATPase; Region: Arch_ATPase; pfam01637
449447002037	AAA domain; Region: AAA_14; pfam13173
449447002038	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447002039	metal ion-dependent adhesion site (MIDAS); other site
449447002040	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
449447002041	active site
449447002042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002043	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002044	Paired Box domain; Region: PAX; cd00131
449447002045	DNA binding site [nucleotide binding]
449447002046	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002047	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002048	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002049	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447002050	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447002051	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447002052	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002053	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
449447002054	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447002055	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
449447002056	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447002057	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447002058	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002059	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002060	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002061	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002062	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447002063	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002064	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447002065	protein I interface; other site
449447002066	D2 interface; other site
449447002067	protein T interface; other site
449447002068	chlorophyll binding site; other site
449447002069	beta carotene binding site; other site
449447002070	pheophytin binding site; other site
449447002071	manganese-stabilizing polypeptide interface; other site
449447002072	CP43 interface; other site
449447002073	protein L interface; other site
449447002074	oxygen evolving complex binding site; other site
449447002075	bromide binding site; other site
449447002076	quinone binding site; other site
449447002077	Fe binding site [ion binding]; other site
449447002078	core light harvesting interface; other site
449447002079	cytochrome b559 alpha subunit interface; other site
449447002080	cytochrome c-550 interface; other site
449447002081	protein J interface; other site
449447002082	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447002083	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
449447002084	substrate binding site; other site
449447002085	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447002086	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002087	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447002088	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
449447002089	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
449447002090	NAD binding site [chemical binding]; other site
449447002091	homotetramer interface [polypeptide binding]; other site
449447002092	homodimer interface [polypeptide binding]; other site
449447002093	substrate binding site [chemical binding]; other site
449447002094	active site
449447002095	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
449447002096	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447002097	inhibitor-cofactor binding pocket; inhibition site
449447002098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002099	catalytic residue [active]
449447002100	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
449447002101	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447002102	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002103	NAD(P) binding site [chemical binding]; other site
449447002104	active site
449447002105	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447002106	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447002107	Ligand binding site; other site
449447002108	Putative Catalytic site; other site
449447002109	DXD motif; other site
449447002110	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002111	putative active site [active]
449447002112	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002113	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002114	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002115	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002116	putative active site [active]
449447002117	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447002118	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447002119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002120	NAD(P) binding site [chemical binding]; other site
449447002121	active site
449447002122	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
449447002123	TPP-binding site [chemical binding]; other site
449447002124	dimer interface [polypeptide binding]; other site
449447002125	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
449447002126	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447002127	PYR/PP interface [polypeptide binding]; other site
449447002128	dimer interface [polypeptide binding]; other site
449447002129	TPP binding site [chemical binding]; other site
449447002130	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447002131	Predicted membrane protein [Function unknown]; Region: COG2246
449447002132	GtrA-like protein; Region: GtrA; pfam04138
449447002133	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447002134	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447002135	Ligand binding site; other site
449447002136	Putative Catalytic site; other site
449447002137	DXD motif; other site
449447002138	YciI-like protein; Reviewed; Region: PRK12864
449447002139	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447002140	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
449447002141	Walker A/P-loop; other site
449447002142	ATP binding site [chemical binding]; other site
449447002143	Q-loop/lid; other site
449447002144	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
449447002145	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
449447002146	ABC transporter signature motif; other site
449447002147	Walker B; other site
449447002148	D-loop; other site
449447002149	H-loop/switch region; other site
449447002150	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447002151	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447002152	B12 binding site [chemical binding]; other site
449447002153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002154	FeS/SAM binding site; other site
449447002155	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447002156	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447002157	structural tetrad; other site
449447002158	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
449447002159	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
449447002160	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
449447002161	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
449447002162	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
449447002163	homotrimer interaction site [polypeptide binding]; other site
449447002164	putative active site [active]
449447002165	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447002166	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447002167	AAA domain; Region: AAA_31; pfam13614
449447002168	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447002169	P-loop; other site
449447002170	Magnesium ion binding site [ion binding]; other site
449447002171	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
449447002172	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
449447002173	HIGH motif; other site
449447002174	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447002175	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
449447002176	active site
449447002177	KMSKS motif; other site
449447002178	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
449447002179	tRNA binding surface [nucleotide binding]; other site
449447002180	anticodon binding site; other site
449447002181	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
449447002182	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002183	putative active site [active]
449447002184	Bacterial sugar transferase; Region: Bac_transf; pfam02397
449447002185	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447002186	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002187	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447002188	RRXRR protein; Region: RRXRR; pfam14239
449447002189	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
449447002190	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
449447002191	putative active site [active]
449447002192	Double zinc ribbon; Region: DZR; pfam12773
449447002193	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447002194	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447002195	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447002196	phosphopeptide binding site; other site
449447002197	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
449447002198	Peptidase family M50; Region: Peptidase_M50; pfam02163
449447002199	active site
449447002200	putative substrate binding region [chemical binding]; other site
449447002201	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
449447002202	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447002203	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
449447002204	active site
449447002205	metal binding site [ion binding]; metal-binding site
449447002206	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
449447002207	triosephosphate isomerase; Provisional; Region: PRK14565
449447002208	dimer interface [polypeptide binding]; other site
449447002209	substrate binding site [chemical binding]; other site
449447002210	catalytic triad [active]
449447002211	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
449447002212	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
449447002213	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
449447002214	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002215	putative active site [active]
449447002216	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
449447002217	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002218	putative active site [active]
449447002219	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002220	putative active site [active]
449447002221	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
449447002222	30S subunit binding site; other site
449447002223	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
449447002224	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
449447002225	putative dimer interface [polypeptide binding]; other site
449447002226	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
449447002227	hypothetical protein; Provisional; Region: PRK04194
449447002228	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002229	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002230	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
449447002231	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447002232	active site
449447002233	NTP binding site [chemical binding]; other site
449447002234	metal binding triad [ion binding]; metal-binding site
449447002235	antibiotic binding site [chemical binding]; other site
449447002236	AAA domain; Region: AAA_13; pfam13166
449447002237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002238	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002239	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447002240	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002241	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447002242	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447002243	Peptidase family M48; Region: Peptidase_M48; cl12018
449447002244	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447002245	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
449447002246	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
449447002247	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447002248	metal ion-dependent adhesion site (MIDAS); other site
449447002249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002250	Probable transposase; Region: OrfB_IS605; pfam01385
449447002251	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002252	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
449447002253	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
449447002254	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
449447002255	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
449447002256	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
449447002257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447002258	AAA domain; Region: AAA_21; pfam13304
449447002259	Walker A/P-loop; other site
449447002260	ATP binding site [chemical binding]; other site
449447002261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447002262	Q-loop/lid; other site
449447002263	ABC transporter signature motif; other site
449447002264	Walker B; other site
449447002265	D-loop; other site
449447002266	H-loop/switch region; other site
449447002267	cytochrome c-550; Provisional; Region: psbV; PRK13619
449447002268	hypothetical protein; Provisional; Region: PRK04323
449447002269	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
449447002270	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
449447002271	catalytic site [active]
449447002272	G-X2-G-X-G-K; other site
449447002273	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002274	Probable transposase; Region: OrfB_IS605; pfam01385
449447002275	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002276	Clp protease; Region: CLP_protease; pfam00574
449447002277	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447002278	oligomer interface [polypeptide binding]; other site
449447002279	active site residues [active]
449447002280	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
449447002281	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
449447002282	photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553
449447002283	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002284	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002285	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002286	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002287	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002288	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002289	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447002290	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447002291	dimerization interface [polypeptide binding]; other site
449447002292	putative DNA binding site [nucleotide binding]; other site
449447002293	putative Zn2+ binding site [ion binding]; other site
449447002294	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
449447002295	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
449447002296	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
449447002297	feruloyl-CoA synthase; Reviewed; Region: PRK08180
449447002298	Protein of unknown function DUF91; Region: DUF91; cl00709
449447002299	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447002300	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447002301	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447002302	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
449447002303	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
449447002304	Protein of unknown function (DUF512); Region: DUF512; pfam04459
449447002305	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
449447002306	Permease; Region: Permease; cl00510
449447002307	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
449447002308	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
449447002309	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
449447002310	putative RNA binding site [nucleotide binding]; other site
449447002311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447002312	S-adenosylmethionine binding site [chemical binding]; other site
449447002313	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447002314	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447002315	active site
449447002316	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
449447002317	classical (c) SDRs; Region: SDR_c; cd05233
449447002318	NAD(P) binding site [chemical binding]; other site
449447002319	active site
449447002320	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
449447002321	active site
449447002322	reticulocyte binding protein 2-like protein; Provisional; Region: PTZ00440
449447002323	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447002324	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
449447002325	magnesium chelatase subunit H; Provisional; Region: PRK12493
449447002326	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447002327	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447002328	HEPN domain; Region: HEPN; cl00824
449447002329	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447002330	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447002331	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
449447002332	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447002333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002334	active site
449447002335	phosphorylation site [posttranslational modification]
449447002336	intermolecular recognition site; other site
449447002337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447002338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002339	dimer interface [polypeptide binding]; other site
449447002340	phosphorylation site [posttranslational modification]
449447002341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002342	ATP binding site [chemical binding]; other site
449447002343	Mg2+ binding site [ion binding]; other site
449447002344	G-X-G motif; other site
449447002345	Response regulator receiver domain; Region: Response_reg; pfam00072
449447002346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002347	active site
449447002348	phosphorylation site [posttranslational modification]
449447002349	intermolecular recognition site; other site
449447002350	dimerization interface [polypeptide binding]; other site
449447002351	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
449447002352	GAF domain; Region: GAF; pfam01590
449447002353	Phytochrome region; Region: PHY; pfam00360
449447002354	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002355	dimer interface [polypeptide binding]; other site
449447002356	phosphorylation site [posttranslational modification]
449447002357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002358	ATP binding site [chemical binding]; other site
449447002359	Mg2+ binding site [ion binding]; other site
449447002360	G-X-G motif; other site
449447002361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
449447002362	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
449447002363	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
449447002364	active site
449447002365	Zn binding site [ion binding]; other site
449447002366	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
449447002367	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
449447002368	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
449447002369	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
449447002370	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447002371	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
449447002372	NAD(P) binding site [chemical binding]; other site
449447002373	homodimer interface [polypeptide binding]; other site
449447002374	substrate binding site [chemical binding]; other site
449447002375	active site
449447002376	carotene isomerase; Region: carot_isom; TIGR02730
449447002377	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447002378	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447002379	ABC1 family; Region: ABC1; cl17513
449447002380	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
449447002381	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
449447002382	catalytic triad [active]
449447002383	putative active site [active]
449447002384	Calx-beta domain; Region: Calx-beta; cl02522
449447002385	Calx-beta domain; Region: Calx-beta; cl02522
449447002386	Calx-beta domain; Region: Calx-beta; cl02522
449447002387	Calx-beta domain; Region: Calx-beta; cl02522
449447002388	Calx-beta domain; Region: Calx-beta; cl02522
449447002389	Calx-beta domain; Region: Calx-beta; cl02522
449447002390	Calx-beta domain; Region: Calx-beta; cl02522
449447002391	Calx-beta domain; Region: Calx-beta; cl02522
449447002392	Calx-beta domain; Region: Calx-beta; cl02522
449447002393	Calx-beta domain; Region: Calx-beta; cl02522
449447002394	Calx-beta domain; Region: Calx-beta; cl02522
449447002395	Calx-beta domain; Region: Calx-beta; cl02522
449447002396	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002397	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
449447002398	active site
449447002399	catalytic triad [active]
449447002400	Calx-beta domain; Region: Calx-beta; cl02522
449447002401	Calx-beta domain; Region: Calx-beta; cl02522
449447002402	Calx-beta domain; Region: Calx-beta; pfam03160
449447002403	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
449447002404	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
449447002405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447002406	Walker A/P-loop; other site
449447002407	ATP binding site [chemical binding]; other site
449447002408	Q-loop/lid; other site
449447002409	ABC transporter signature motif; other site
449447002410	Walker B; other site
449447002411	D-loop; other site
449447002412	H-loop/switch region; other site
449447002413	TOBE domain; Region: TOBE_2; pfam08402
449447002414	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
449447002415	RimK-like ATP-grasp domain; Region: RimK; pfam08443
449447002416	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447002417	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447002418	CHAT domain; Region: CHAT; pfam12770
449447002419	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
449447002420	putative active site [active]
449447002421	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447002422	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
449447002423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002424	FeS/SAM binding site; other site
449447002425	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
449447002426	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
449447002427	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
449447002428	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
449447002429	dimerization interface [polypeptide binding]; other site
449447002430	FAD binding pocket [chemical binding]; other site
449447002431	FAD binding motif [chemical binding]; other site
449447002432	catalytic residues [active]
449447002433	NAD binding pocket [chemical binding]; other site
449447002434	phosphate binding motif [ion binding]; other site
449447002435	beta-alpha-beta structure motif; other site
449447002436	Protein of unknown function, DUF399; Region: DUF399; pfam04187
449447002437	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
449447002438	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
449447002439	active site
449447002440	Predicted GTPase [General function prediction only]; Region: COG3596
449447002441	YfjP GTPase; Region: YfjP; cd11383
449447002442	G1 box; other site
449447002443	GTP/Mg2+ binding site [chemical binding]; other site
449447002444	Switch I region; other site
449447002445	G2 box; other site
449447002446	Switch II region; other site
449447002447	G3 box; other site
449447002448	G4 box; other site
449447002449	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447002450	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447002451	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
449447002452	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
449447002453	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
449447002454	Active Sites [active]
449447002455	Family description; Region: VCBS; pfam13517
449447002456	Family description; Region: VCBS; pfam13517
449447002457	Family description; Region: VCBS; pfam13517
449447002458	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
449447002459	Protein of unknown function (DUF1702); Region: DUF1702; pfam08012
449447002460	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
449447002461	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447002462	DevC protein; Region: devC; TIGR01185
449447002463	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447002464	FtsX-like permease family; Region: FtsX; pfam02687
449447002465	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
449447002466	active site
449447002467	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447002468	putative active site [active]
449447002469	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
449447002470	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447002471	active site
449447002472	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447002473	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447002474	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
449447002475	active site
449447002476	NAD binding site [chemical binding]; other site
449447002477	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447002478	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
449447002479	putative NADP binding site [chemical binding]; other site
449447002480	active site
449447002481	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
449447002482	active site 2 [active]
449447002483	dimer interface [polypeptide binding]; other site
449447002484	active site 1 [active]
449447002485	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
449447002486	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
449447002487	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002488	putative active site [active]
449447002489	Pirin-related protein [General function prediction only]; Region: COG1741
449447002490	Pirin; Region: Pirin; pfam02678
449447002491	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
449447002492	active site lid residues [active]
449447002493	substrate binding pocket [chemical binding]; other site
449447002494	catalytic residues [active]
449447002495	substrate-Mg2+ binding site; other site
449447002496	aspartate-rich region 1; other site
449447002497	aspartate-rich region 2; other site
449447002498	phytoene desaturase; Region: phytoene_desat; TIGR02731
449447002499	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447002500	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447002501	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
449447002502	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447002503	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447002504	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447002505	motif II; other site
449447002506	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447002507	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
449447002508	transmembrane helices; other site
449447002509	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
449447002510	TrkA-C domain; Region: TrkA_C; pfam02080
449447002511	TrkA-C domain; Region: TrkA_C; pfam02080
449447002512	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
449447002513	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447002514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002515	binding surface
449447002516	TPR motif; other site
449447002517	TPR repeat; Region: TPR_11; pfam13414
449447002518	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
449447002519	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447002520	substrate binding pocket [chemical binding]; other site
449447002521	membrane-bound complex binding site; other site
449447002522	hinge residues; other site
449447002523	Response regulator receiver domain; Region: Response_reg; pfam00072
449447002524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002525	active site
449447002526	phosphorylation site [posttranslational modification]
449447002527	intermolecular recognition site; other site
449447002528	dimerization interface [polypeptide binding]; other site
449447002529	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
449447002530	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
449447002531	metal binding site [ion binding]; metal-binding site
449447002532	active site
449447002533	I-site; other site
449447002534	DEAD-like helicases superfamily; Region: DEXDc; smart00487
449447002535	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447002536	ATP binding site [chemical binding]; other site
449447002537	putative Mg++ binding site [ion binding]; other site
449447002538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447002539	nucleotide binding region [chemical binding]; other site
449447002540	ATP-binding site [chemical binding]; other site
449447002541	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
449447002542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002543	TPR repeat; Region: TPR_11; pfam13414
449447002544	binding surface
449447002545	TPR motif; other site
449447002546	TPR repeat; Region: TPR_11; pfam13414
449447002547	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002548	binding surface
449447002549	TPR motif; other site
449447002550	TPR repeat; Region: TPR_11; pfam13414
449447002551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002552	binding surface
449447002553	TPR motif; other site
449447002554	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
449447002555	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
449447002556	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002557	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
449447002558	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447002559	seryl-tRNA synthetase; Provisional; Region: PRK05431
449447002560	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
449447002561	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
449447002562	dimer interface [polypeptide binding]; other site
449447002563	active site
449447002564	motif 1; other site
449447002565	motif 2; other site
449447002566	motif 3; other site
449447002567	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
449447002568	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
449447002569	dimer interface [polypeptide binding]; other site
449447002570	active site
449447002571	catalytic residue [active]
449447002572	metal binding site [ion binding]; metal-binding site
449447002573	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
449447002574	active site
449447002575	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447002576	active site
449447002577	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002578	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447002579	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447002580	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
449447002581	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
449447002582	Methyltransferase domain; Region: Methyltransf_12; pfam08242
449447002583	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
449447002584	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447002585	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447002586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447002587	S-adenosylmethionine binding site [chemical binding]; other site
449447002588	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002589	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447002590	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002591	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447002592	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447002593	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
449447002594	proline aminopeptidase P II; Provisional; Region: PRK10879
449447002595	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
449447002596	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
449447002597	active site
449447002598	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002599	putative active site [active]
449447002600	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002601	putative active site [active]
449447002602	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
449447002603	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
449447002604	nucleotide binding pocket [chemical binding]; other site
449447002605	K-X-D-G motif; other site
449447002606	catalytic site [active]
449447002607	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
449447002608	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
449447002609	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
449447002610	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
449447002611	Dimer interface [polypeptide binding]; other site
449447002612	BRCT sequence motif; other site
449447002613	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447002614	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447002615	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
449447002616	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
449447002617	hypothetical protein; Reviewed; Region: PRK12497
449447002618	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447002619	catalytic core [active]
449447002620	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
449447002621	catalytic core [active]
449447002622	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
449447002623	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
449447002624	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
449447002625	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447002626	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447002627	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447002628	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447002629	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447002630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447002631	Walker A/P-loop; other site
449447002632	ATP binding site [chemical binding]; other site
449447002633	Q-loop/lid; other site
449447002634	ABC transporter signature motif; other site
449447002635	Walker B; other site
449447002636	D-loop; other site
449447002637	H-loop/switch region; other site
449447002638	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447002639	active site
449447002640	metal binding site [ion binding]; metal-binding site
449447002641	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447002642	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447002643	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002644	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447002645	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
449447002646	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002647	putative active site [active]
449447002648	GUN4-like; Region: GUN4; pfam05419
449447002649	PIN domain; Region: PIN_3; pfam13470
449447002650	Transglycosylase; Region: Transgly; pfam00912
449447002651	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447002652	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
449447002653	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447002654	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002655	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447002656	hypothetical protein; Validated; Region: PRK00110
449447002657	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
449447002658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447002659	FeS/SAM binding site; other site
449447002660	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
449447002661	hypothetical protein; Reviewed; Region: PRK09588
449447002662	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
449447002663	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
449447002664	nucleotide binding site [chemical binding]; other site
449447002665	NEF interaction site [polypeptide binding]; other site
449447002666	SBD interface [polypeptide binding]; other site
449447002667	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
449447002668	protochlorophyllide oxidoreductase; Validated; Region: PRK07453
449447002669	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
449447002670	NAD(P) binding site [chemical binding]; other site
449447002671	active site
449447002672	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
449447002673	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
449447002674	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447002675	catalytic loop [active]
449447002676	iron binding site [ion binding]; other site
449447002677	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447002678	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
449447002679	CAAX protease self-immunity; Region: Abi; pfam02517
449447002680	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
449447002681	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
449447002682	RimM N-terminal domain; Region: RimM; pfam01782
449447002683	PRC-barrel domain; Region: PRC; pfam05239
449447002684	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447002685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002686	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002687	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002688	putative active site [active]
449447002689	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002690	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002691	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002692	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447002693	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
449447002694	Homeodomain-like domain; Region: HTH_23; cl17451
449447002695	Winged helix-turn helix; Region: HTH_29; pfam13551
449447002696	Homeodomain-like domain; Region: HTH_32; pfam13565
449447002697	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002698	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447002699	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
449447002700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447002701	catalytic residue [active]
449447002702	serine O-acetyltransferase; Region: cysE; TIGR01172
449447002703	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447002704	trimer interface [polypeptide binding]; other site
449447002705	active site
449447002706	substrate binding site [chemical binding]; other site
449447002707	CoA binding site [chemical binding]; other site
449447002708	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447002709	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447002710	dimer interface [polypeptide binding]; other site
449447002711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002712	catalytic residue [active]
449447002713	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002714	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447002715	Probable transposase; Region: OrfB_IS605; pfam01385
449447002716	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447002718	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447002719	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447002720	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447002721	Probable transposase; Region: OrfB_IS605; pfam01385
449447002722	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447002723	PemK-like protein; Region: PemK; pfam02452
449447002724	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
449447002725	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447002726	Uncharacterized conserved protein [Function unknown]; Region: COG3391
449447002727	NHL repeat; Region: NHL; pfam01436
449447002728	NHL repeat; Region: NHL; pfam01436
449447002729	NHL repeat; Region: NHL; pfam01436
449447002730	NHL repeat; Region: NHL; pfam01436
449447002731	NHL repeat; Region: NHL; pfam01436
449447002732	NHL repeat; Region: NHL; pfam01436
449447002733	putative transposase; Provisional; Region: PRK09857
449447002734	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447002735	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447002736	DNA-binding interface [nucleotide binding]; DNA binding site
449447002737	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002738	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447002739	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447002740	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447002741	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447002742	DNA methylase; Region: N6_N4_Mtase; cl17433
449447002743	dihydroorotase; Provisional; Region: PRK07369
449447002744	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
449447002745	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
449447002746	active site
449447002747	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447002748	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447002749	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447002750	putative active site [active]
449447002751	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
449447002752	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
449447002753	RNA polymerase sigma factor; Validated; Region: PRK05949
449447002754	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447002755	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447002756	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447002757	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447002758	DNA binding residues [nucleotide binding]
449447002759	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
449447002760	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
449447002761	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
449447002762	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447002763	TPR repeat; Region: TPR_11; pfam13414
449447002764	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002765	binding surface
449447002766	TPR motif; other site
449447002767	TPR repeat; Region: TPR_11; pfam13414
449447002768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002769	binding surface
449447002770	TPR motif; other site
449447002771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002772	binding surface
449447002773	TPR motif; other site
449447002774	TPR repeat; Region: TPR_11; pfam13414
449447002775	HEAT repeats; Region: HEAT_2; pfam13646
449447002776	HEAT repeats; Region: HEAT_2; pfam13646
449447002777	TPR repeat; Region: TPR_11; pfam13414
449447002778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447002779	binding surface
449447002780	TPR motif; other site
449447002781	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447002782	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447002783	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
449447002784	Walker A/P-loop; other site
449447002785	ATP binding site [chemical binding]; other site
449447002786	Q-loop/lid; other site
449447002787	ABC transporter signature motif; other site
449447002788	Walker B; other site
449447002789	D-loop; other site
449447002790	H-loop/switch region; other site
449447002791	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
449447002792	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
449447002793	active site
449447002794	zinc binding site [ion binding]; other site
449447002795	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
449447002796	translation initiation factor IF-2; Region: IF-2; TIGR00487
449447002797	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
449447002798	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
449447002799	G1 box; other site
449447002800	putative GEF interaction site [polypeptide binding]; other site
449447002801	GTP/Mg2+ binding site [chemical binding]; other site
449447002802	Switch I region; other site
449447002803	G2 box; other site
449447002804	G3 box; other site
449447002805	Switch II region; other site
449447002806	G4 box; other site
449447002807	G5 box; other site
449447002808	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
449447002809	Translation-initiation factor 2; Region: IF-2; pfam11987
449447002810	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
449447002811	Protein of unknown function (DUF448); Region: DUF448; pfam04296
449447002812	putative RNA binding cleft [nucleotide binding]; other site
449447002813	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
449447002814	NusA N-terminal domain; Region: NusA_N; pfam08529
449447002815	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
449447002816	RNA binding site [nucleotide binding]; other site
449447002817	homodimer interface [polypeptide binding]; other site
449447002818	NusA-like KH domain; Region: KH_5; pfam13184
449447002819	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
449447002820	G-X-X-G motif; other site
449447002821	ribosome maturation protein RimP; Reviewed; Region: PRK00092
449447002822	Sm and related proteins; Region: Sm_like; cl00259
449447002823	heptamer interface [polypeptide binding]; other site
449447002824	Sm1 motif; other site
449447002825	hexamer interface [polypeptide binding]; other site
449447002826	RNA binding site [nucleotide binding]; other site
449447002827	Sm2 motif; other site
449447002828	cell division protein; Validated; Region: ftsH; CHL00176
449447002829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447002830	Walker A motif; other site
449447002831	ATP binding site [chemical binding]; other site
449447002832	Walker B motif; other site
449447002833	arginine finger; other site
449447002834	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447002835	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447002836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447002837	active site
449447002838	phosphorylation site [posttranslational modification]
449447002839	intermolecular recognition site; other site
449447002840	dimerization interface [polypeptide binding]; other site
449447002841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447002842	DNA binding site [nucleotide binding]
449447002843	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
449447002844	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447002845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447002846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447002847	phosphorylation site [posttranslational modification]
449447002848	dimer interface [polypeptide binding]; other site
449447002849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447002850	ATP binding site [chemical binding]; other site
449447002851	Mg2+ binding site [ion binding]; other site
449447002852	G-X-G motif; other site
449447002853	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447002854	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447002855	DNA-binding interface [nucleotide binding]; DNA binding site
449447002856	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447002857	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447002858	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
449447002859	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447002860	DRTGG domain; Region: DRTGG; pfam07085
449447002861	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447002862	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
449447002863	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447002864	Walker A/P-loop; other site
449447002865	ATP binding site [chemical binding]; other site
449447002866	Q-loop/lid; other site
449447002867	ABC transporter signature motif; other site
449447002868	Walker B; other site
449447002869	D-loop; other site
449447002870	H-loop/switch region; other site
449447002871	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
449447002872	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
449447002873	homodimer interface [polypeptide binding]; other site
449447002874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447002875	catalytic residue [active]
449447002876	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
449447002877	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447002878	active site
449447002879	ATP binding site [chemical binding]; other site
449447002880	substrate binding site [chemical binding]; other site
449447002881	activation loop (A-loop); other site
449447002882	CTP synthetase; Validated; Region: pyrG; PRK05380
449447002883	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
449447002884	Catalytic site [active]
449447002885	active site
449447002886	UTP binding site [chemical binding]; other site
449447002887	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
449447002888	active site
449447002889	putative oxyanion hole; other site
449447002890	catalytic triad [active]
449447002891	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447002892	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447002893	catalytic loop [active]
449447002894	iron binding site [ion binding]; other site
449447002895	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
449447002896	active site
449447002897	catalytic residues [active]
449447002898	metal binding site [ion binding]; metal-binding site
449447002899	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447002900	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447002901	active site
449447002902	ATP binding site [chemical binding]; other site
449447002903	substrate binding site [chemical binding]; other site
449447002904	activation loop (A-loop); other site
449447002905	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
449447002906	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
449447002907	substrate binding pocket [chemical binding]; other site
449447002908	chain length determination region; other site
449447002909	substrate-Mg2+ binding site; other site
449447002910	catalytic residues [active]
449447002911	aspartate-rich region 1; other site
449447002912	active site lid residues [active]
449447002913	aspartate-rich region 2; other site
449447002914	Divergent PAP2 family; Region: DUF212; pfam02681
449447002915	dihydrodipicolinate reductase; Provisional; Region: PRK00048
449447002916	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
449447002917	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
449447002918	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447002919	active site
449447002920	NTP binding site [chemical binding]; other site
449447002921	metal binding triad [ion binding]; metal-binding site
449447002922	antibiotic binding site [chemical binding]; other site
449447002923	membrane protein; Provisional; Region: PRK14419
449447002924	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447002925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447002926	NAD(P) binding site [chemical binding]; other site
449447002927	active site
449447002928	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447002929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447002930	Walker A/P-loop; other site
449447002931	ATP binding site [chemical binding]; other site
449447002932	Q-loop/lid; other site
449447002933	ABC transporter signature motif; other site
449447002934	Walker B; other site
449447002935	D-loop; other site
449447002936	H-loop/switch region; other site
449447002937	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447002938	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447002939	P-loop; other site
449447002940	Magnesium ion binding site [ion binding]; other site
449447002941	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447002942	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
449447002943	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
449447002944	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
449447002945	trimer interface [polypeptide binding]; other site
449447002946	active site
449447002947	UDP-GlcNAc binding site [chemical binding]; other site
449447002948	lipid binding site [chemical binding]; lipid-binding site
449447002949	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
449447002950	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
449447002951	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
449447002952	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
449447002953	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
449447002954	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
449447002955	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
449447002956	ThiS interaction site; other site
449447002957	putative active site [active]
449447002958	tetramer interface [polypeptide binding]; other site
449447002959	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
449447002960	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447002961	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447002962	Walker A/P-loop; other site
449447002963	ATP binding site [chemical binding]; other site
449447002964	Q-loop/lid; other site
449447002965	ABC transporter signature motif; other site
449447002966	Walker B; other site
449447002967	D-loop; other site
449447002968	H-loop/switch region; other site
449447002969	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447002970	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447002971	Walker A/P-loop; other site
449447002972	ATP binding site [chemical binding]; other site
449447002973	Q-loop/lid; other site
449447002974	ABC transporter signature motif; other site
449447002975	Walker B; other site
449447002976	D-loop; other site
449447002977	H-loop/switch region; other site
449447002978	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447002979	NMT1-like family; Region: NMT1_2; pfam13379
449447002980	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447002981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447002982	dimer interface [polypeptide binding]; other site
449447002983	conserved gate region; other site
449447002984	putative PBP binding loops; other site
449447002985	ABC-ATPase subunit interface; other site
449447002986	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447002987	NMT1-like family; Region: NMT1_2; pfam13379
449447002988	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447002989	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
449447002990	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
449447002991	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447002992	catalytic residue [active]
449447002993	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447002994	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
449447002995	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447002996	putative active site [active]
449447002997	putative metal binding site [ion binding]; other site
449447002998	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
449447002999	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
449447003000	dimer interface [polypeptide binding]; other site
449447003001	ADP-ribose binding site [chemical binding]; other site
449447003002	active site
449447003003	nudix motif; other site
449447003004	metal binding site [ion binding]; metal-binding site
449447003005	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
449447003006	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
449447003007	GTP/Mg2+ binding site [chemical binding]; other site
449447003008	G4 box; other site
449447003009	G5 box; other site
449447003010	G1 box; other site
449447003011	Switch I region; other site
449447003012	G2 box; other site
449447003013	G3 box; other site
449447003014	Switch II region; other site
449447003015	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
449447003016	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447003017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447003018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003019	active site
449447003020	phosphorylation site [posttranslational modification]
449447003021	intermolecular recognition site; other site
449447003022	dimerization interface [polypeptide binding]; other site
449447003023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447003024	DNA binding site [nucleotide binding]
449447003025	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
449447003026	heme binding pocket [chemical binding]; other site
449447003027	heme ligand [chemical binding]; other site
449447003028	acyl carrier protein; Provisional; Region: acpP; PRK00982
449447003029	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
449447003030	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
449447003031	dimer interface [polypeptide binding]; other site
449447003032	active site
449447003033	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
449447003034	transketolase; Region: PLN02790
449447003035	TPP-binding site [chemical binding]; other site
449447003036	dimer interface [polypeptide binding]; other site
449447003037	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447003038	PYR/PP interface [polypeptide binding]; other site
449447003039	dimer interface [polypeptide binding]; other site
449447003040	TPP binding site [chemical binding]; other site
449447003041	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447003042	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
449447003043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003044	non-specific DNA binding site [nucleotide binding]; other site
449447003045	salt bridge; other site
449447003046	sequence-specific DNA binding site [nucleotide binding]; other site
449447003047	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
449447003048	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
449447003049	Domain of unknown function DUF21; Region: DUF21; pfam01595
449447003050	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
449447003051	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
449447003052	Transporter associated domain; Region: CorC_HlyC; pfam03471
449447003053	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
449447003054	MltA specific insert domain; Region: MltA; pfam03562
449447003055	3D domain; Region: 3D; pfam06725
449447003056	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
449447003057	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447003058	FeS/SAM binding site; other site
449447003059	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
449447003060	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003061	putative active site [active]
449447003062	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447003063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447003064	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
449447003065	putative dimerization interface [polypeptide binding]; other site
449447003066	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
449447003067	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447003068	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
449447003069	active site clefts [active]
449447003070	zinc binding site [ion binding]; other site
449447003071	dimer interface [polypeptide binding]; other site
449447003072	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
449447003073	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447003074	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
449447003075	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003076	putative active site [active]
449447003077	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
449447003078	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
449447003079	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
449447003080	homodimer interface [polypeptide binding]; other site
449447003081	oligonucleotide binding site [chemical binding]; other site
449447003082	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
449447003083	RNA/DNA hybrid binding site [nucleotide binding]; other site
449447003084	active site
449447003085	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
449447003086	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
449447003087	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
449447003088	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
449447003089	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
449447003090	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447003091	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447003092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003093	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447003094	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003095	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447003096	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447003097	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447003098	structural tetrad; other site
449447003099	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447003100	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447003101	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447003102	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447003103	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447003104	catalytic triad [active]
449447003105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003106	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003107	Probable transposase; Region: OrfB_IS605; pfam01385
449447003108	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003109	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
449447003110	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
449447003111	hinge; other site
449447003112	active site
449447003113	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003114	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447003115	Walker A/P-loop; other site
449447003116	ATP binding site [chemical binding]; other site
449447003117	Q-loop/lid; other site
449447003118	ABC transporter signature motif; other site
449447003119	Walker B; other site
449447003120	D-loop; other site
449447003121	H-loop/switch region; other site
449447003122	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447003123	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003124	Walker A/P-loop; other site
449447003125	ATP binding site [chemical binding]; other site
449447003126	Q-loop/lid; other site
449447003127	ABC transporter signature motif; other site
449447003128	Walker B; other site
449447003129	D-loop; other site
449447003130	H-loop/switch region; other site
449447003131	amidophosphoribosyltransferase; Provisional; Region: PRK07349
449447003132	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
449447003133	active site
449447003134	tetramer interface [polypeptide binding]; other site
449447003135	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447003136	active site
449447003137	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
449447003138	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
449447003139	dimerization interface [polypeptide binding]; other site
449447003140	ATP binding site [chemical binding]; other site
449447003141	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
449447003142	dimerization interface [polypeptide binding]; other site
449447003143	ATP binding site [chemical binding]; other site
449447003144	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447003145	YcfA-like protein; Region: YcfA; pfam07927
449447003146	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447003147	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447003148	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447003149	non-specific DNA binding site [nucleotide binding]; other site
449447003150	salt bridge; other site
449447003151	sequence-specific DNA binding site [nucleotide binding]; other site
449447003152	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
449447003153	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
449447003154	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003155	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003156	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003157	Homeodomain-like domain; Region: HTH_32; pfam13565
449447003158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447003159	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447003160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447003161	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447003162	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447003163	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447003164	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447003165	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
449447003166	NifU-like domain; Region: NifU; pfam01106
449447003167	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
449447003168	Circadian oscillating protein COP23; Region: COP23; pfam14218
449447003169	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447003170	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447003171	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447003172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447003173	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447003174	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447003175	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447003176	acetylornithine aminotransferase; Provisional; Region: PRK02627
449447003177	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447003178	inhibitor-cofactor binding pocket; inhibition site
449447003179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003180	catalytic residue [active]
449447003181	Ion channel; Region: Ion_trans_2; pfam07885
449447003182	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447003183	TrkA-N domain; Region: TrkA_N; pfam02254
449447003184	TrkA-C domain; Region: TrkA_C; pfam02080
449447003185	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003187	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003188	Probable transposase; Region: OrfB_IS605; pfam01385
449447003189	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003190	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
449447003191	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447003192	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
449447003193	Walker A motif; other site
449447003194	Walker A/P-loop; other site
449447003195	ATP binding site [chemical binding]; other site
449447003196	ATP binding site [chemical binding]; other site
449447003197	Walker B motif; other site
449447003198	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447003199	tetramer interface [polypeptide binding]; other site
449447003200	dimer interface [polypeptide binding]; other site
449447003201	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
449447003202	putative active site [active]
449447003203	Zn binding site [ion binding]; other site
449447003204	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
449447003205	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447003206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003207	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447003208	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003209	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447003210	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003211	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003212	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003213	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003214	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003215	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
449447003216	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
449447003217	C-terminal domain interface [polypeptide binding]; other site
449447003218	GSH binding site (G-site) [chemical binding]; other site
449447003219	dimer interface [polypeptide binding]; other site
449447003220	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
449447003221	N-terminal domain interface [polypeptide binding]; other site
449447003222	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447003223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003224	active site
449447003225	phosphorylation site [posttranslational modification]
449447003226	intermolecular recognition site; other site
449447003227	dimerization interface [polypeptide binding]; other site
449447003228	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447003229	DNA binding site [nucleotide binding]
449447003230	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
449447003231	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
449447003232	active site
449447003233	molecular chaperone DnaK; Provisional; Region: PRK13410
449447003234	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
449447003235	nucleotide binding site [chemical binding]; other site
449447003236	NEF interaction site [polypeptide binding]; other site
449447003237	SBD interface [polypeptide binding]; other site
449447003238	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
449447003239	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447003240	HSP70 interaction site [polypeptide binding]; other site
449447003241	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447003242	dimer interface [polypeptide binding]; other site
449447003243	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
449447003244	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
449447003245	active site
449447003246	catalytic residues [active]
449447003247	FMN binding site [chemical binding]; other site
449447003248	quinone interaction residues [chemical binding]; other site
449447003249	substrate binding site [chemical binding]; other site
449447003250	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
449447003251	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
449447003252	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447003253	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447003254	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
449447003255	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
449447003256	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003257	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003258	Probable transposase; Region: OrfB_IS605; pfam01385
449447003259	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003260	XisH protein; Region: XisH; pfam08814
449447003261	XisI protein; Region: XisI; pfam08869
449447003262	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447003263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447003264	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447003265	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447003266	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447003267	active site
449447003268	catalytic tetrad [active]
449447003269	recombinase A; Provisional; Region: recA; PRK09354
449447003270	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
449447003271	hexamer interface [polypeptide binding]; other site
449447003272	Walker A motif; other site
449447003273	ATP binding site [chemical binding]; other site
449447003274	Walker B motif; other site
449447003275	TIGR02594 family protein; Region: TIGR02594
449447003276	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
449447003277	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
449447003278	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447003279	catalytic residue [active]
449447003280	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
449447003281	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
449447003282	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
449447003283	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
449447003284	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
449447003285	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
449447003286	P-loop; other site
449447003287	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
449447003288	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
449447003289	AAA domain; Region: AAA_21; pfam13304
449447003290	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447003291	Walker B; other site
449447003292	D-loop; other site
449447003293	H-loop/switch region; other site
449447003294	RloB-like protein; Region: RloB; pfam13707
449447003295	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
449447003296	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
449447003297	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447003300	binding surface
449447003301	TPR motif; other site
449447003302	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447003303	CHAT domain; Region: CHAT; pfam12770
449447003304	YcfA-like protein; Region: YcfA; pfam07927
449447003305	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
449447003306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003307	non-specific DNA binding site [nucleotide binding]; other site
449447003308	salt bridge; other site
449447003309	sequence-specific DNA binding site [nucleotide binding]; other site
449447003310	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447003311	YcfA-like protein; Region: YcfA; cl00752
449447003312	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447003313	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447003314	putative active site [active]
449447003315	Predicted transcriptional regulator [Transcription]; Region: COG4190
449447003316	YcfA-like protein; Region: YcfA; cl00752
449447003317	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447003318	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447003319	Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; cl01916
449447003320	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003321	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003322	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003323	Homeodomain-like domain; Region: HTH_32; pfam13565
449447003324	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003325	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447003327	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003328	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003329	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003330	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003332	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003333	Probable transposase; Region: OrfB_IS605; pfam01385
449447003334	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003335	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
449447003336	active site
449447003337	FMN binding site [chemical binding]; other site
449447003338	catalytic residues [active]
449447003339	substrate binding site [chemical binding]; other site
449447003340	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003341	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003342	Homeodomain-like domain; Region: HTH_32; pfam13565
449447003343	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003344	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447003346	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
449447003347	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
449447003348	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
449447003349	active site
449447003350	dimer interface [polypeptide binding]; other site
449447003351	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
449447003352	dimer interface [polypeptide binding]; other site
449447003353	active site
449447003354	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447003355	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
449447003356	FtsX-like permease family; Region: FtsX; pfam02687
449447003357	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
449447003358	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003359	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
449447003360	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
449447003361	NAD binding site [chemical binding]; other site
449447003362	dimerization interface [polypeptide binding]; other site
449447003363	product binding site; other site
449447003364	substrate binding site [chemical binding]; other site
449447003365	zinc binding site [ion binding]; other site
449447003366	catalytic residues [active]
449447003367	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
449447003368	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447003369	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
449447003370	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
449447003371	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003372	putative active site [active]
449447003373	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003374	putative active site [active]
449447003375	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003376	putative active site [active]
449447003377	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003378	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003379	putative active site [active]
449447003380	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
449447003381	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
449447003382	nucleotide binding site [chemical binding]; other site
449447003383	putative NEF/HSP70 interaction site [polypeptide binding]; other site
449447003384	SBD interface [polypeptide binding]; other site
449447003385	competence damage-inducible protein A; Provisional; Region: PRK00549
449447003386	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
449447003387	putative MPT binding site; other site
449447003388	Competence-damaged protein; Region: CinA; pfam02464
449447003389	large terminase protein; Provisional; Region: 17; PHA02533
449447003390	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
449447003391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
449447003392	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447003393	Probable transposase; Region: OrfB_IS605; pfam01385
449447003394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003395	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003396	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
449447003397	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
449447003398	active site
449447003399	dimer interface [polypeptide binding]; other site
449447003400	catalytic nucleophile [active]
449447003401	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
449447003402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447003403	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003404	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003405	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
449447003406	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
449447003407	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
449447003408	homoserine kinase; Provisional; Region: PRK01212
449447003409	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447003410	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
449447003411	Homeodomain-like domain; Region: HTH_23; pfam13384
449447003412	Winged helix-turn helix; Region: HTH_29; pfam13551
449447003413	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003414	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003415	Winged helix-turn helix; Region: HTH_33; pfam13592
449447003416	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447003417	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
449447003418	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
449447003419	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
449447003420	MoaE interaction surface [polypeptide binding]; other site
449447003421	MoeB interaction surface [polypeptide binding]; other site
449447003422	thiocarboxylated glycine; other site
449447003423	threonine synthase; Validated; Region: PRK07591
449447003424	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
449447003425	homodimer interface [polypeptide binding]; other site
449447003426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003427	catalytic residue [active]
449447003428	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
449447003429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003430	S-adenosylmethionine binding site [chemical binding]; other site
449447003431	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
449447003432	active site
449447003433	Fe-S cluster binding site [ion binding]; other site
449447003434	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
449447003435	GTPase Era; Reviewed; Region: era; PRK00089
449447003436	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
449447003437	G1 box; other site
449447003438	GTP/Mg2+ binding site [chemical binding]; other site
449447003439	Switch I region; other site
449447003440	G2 box; other site
449447003441	Switch II region; other site
449447003442	G3 box; other site
449447003443	G4 box; other site
449447003444	G5 box; other site
449447003445	KH domain; Region: KH_2; pfam07650
449447003446	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447003447	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447003448	active site
449447003449	ATP binding site [chemical binding]; other site
449447003450	substrate binding site [chemical binding]; other site
449447003451	activation loop (A-loop); other site
449447003452	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447003453	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003454	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003455	Probable transposase; Region: OrfB_IS605; pfam01385
449447003456	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
449447003457	GMP synthase; Reviewed; Region: guaA; PRK00074
449447003458	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
449447003459	AMP/PPi binding site [chemical binding]; other site
449447003460	candidate oxyanion hole; other site
449447003461	catalytic triad [active]
449447003462	potential glutamine specificity residues [chemical binding]; other site
449447003463	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
449447003464	ATP Binding subdomain [chemical binding]; other site
449447003465	Ligand Binding sites [chemical binding]; other site
449447003466	Dimerization subdomain; other site
449447003467	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447003468	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
449447003469	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447003470	cofactor binding site; other site
449447003471	DNA binding site [nucleotide binding]
449447003472	substrate interaction site [chemical binding]; other site
449447003473	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447003474	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
449447003475	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
449447003476	active site
449447003477	catalytic residues [active]
449447003478	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447003479	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447003480	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447003481	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
449447003482	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447003483	sulfite reductase subunit beta; Provisional; Region: PRK13504
449447003484	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003485	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003486	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447003487	phosphopeptide binding site; other site
449447003488	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447003489	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447003490	phosphopeptide binding site; other site
449447003491	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
449447003492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447003493	Walker A/P-loop; other site
449447003494	ATP binding site [chemical binding]; other site
449447003495	Q-loop/lid; other site
449447003496	ABC transporter signature motif; other site
449447003497	Walker B; other site
449447003498	D-loop; other site
449447003499	H-loop/switch region; other site
449447003500	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
449447003501	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
449447003502	methionine sulfoxide reductase A; Provisional; Region: PRK00058
449447003503	von Willebrand factor type D domain; Region: VWD; cl02516
449447003504	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
449447003505	Calx-beta domain; Region: Calx-beta; cl02522
449447003506	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
449447003507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447003508	AAA domain; Region: AAA_21; pfam13304
449447003509	Walker A/P-loop; other site
449447003510	ATP binding site [chemical binding]; other site
449447003511	Caspase domain; Region: Peptidase_C14; pfam00656
449447003512	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
449447003513	ATP-sulfurylase; Region: ATPS; cd00517
449447003514	active site
449447003515	HXXH motif; other site
449447003516	flexible loop; other site
449447003517	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
449447003518	classical (c) SDRs; Region: SDR_c; cd05233
449447003519	NAD(P) binding site [chemical binding]; other site
449447003520	active site
449447003521	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
449447003522	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
449447003523	dimer interface [polypeptide binding]; other site
449447003524	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
449447003525	active site
449447003526	Fe binding site [ion binding]; other site
449447003527	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
449447003528	catalytic motif [active]
449447003529	Catalytic residue [active]
449447003530	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
449447003531	nucleotide binding site/active site [active]
449447003532	HIT family signature motif; other site
449447003533	catalytic residue [active]
449447003534	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
449447003535	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
449447003536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447003537	Walker A motif; other site
449447003538	ATP binding site [chemical binding]; other site
449447003539	Walker B motif; other site
449447003540	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
449447003541	AAA domain; Region: AAA_21; pfam13304
449447003542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447003543	Walker B; other site
449447003544	D-loop; other site
449447003545	H-loop/switch region; other site
449447003546	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
449447003547	pseudouridine synthase; Region: TIGR00093
449447003548	active site
449447003549	ABC-2 type transporter; Region: ABC2_membrane; cl17235
449447003550	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
449447003551	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447003552	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447003553	active site
449447003554	substrate binding site [chemical binding]; other site
449447003555	ATP binding site [chemical binding]; other site
449447003556	activation loop (A-loop); other site
449447003557	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447003558	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447003559	structural tetrad; other site
449447003560	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
449447003561	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
449447003562	putative active site [active]
449447003563	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447003564	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447003565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447003566	active site
449447003567	phosphorylation site [posttranslational modification]
449447003568	intermolecular recognition site; other site
449447003569	dimerization interface [polypeptide binding]; other site
449447003570	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447003571	DNA binding residues [nucleotide binding]
449447003572	dimerization interface [polypeptide binding]; other site
449447003573	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
449447003574	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447003575	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
449447003576	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
449447003577	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
449447003578	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
449447003579	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
449447003580	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003581	putative active site [active]
449447003582	Helix-turn-helix domain; Region: HTH_18; pfam12833
449447003583	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
449447003584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003585	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447003586	S-adenosylmethionine binding site [chemical binding]; other site
449447003587	Domain of unknown function DUF39; Region: DUF39; pfam01837
449447003588	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
449447003589	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447003590	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447003591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003592	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447003593	Probable transposase; Region: OrfB_IS605; pfam01385
449447003594	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003595	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
449447003596	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447003597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
449447003598	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
449447003599	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
449447003600	active site
449447003601	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
449447003602	putative ADP-binding pocket [chemical binding]; other site
449447003603	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003604	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
449447003605	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
449447003606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447003607	catalytic residue [active]
449447003608	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
449447003609	active site
449447003610	catalytic site [active]
449447003611	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
449447003612	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447003613	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
449447003614	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003615	non-specific DNA binding site [nucleotide binding]; other site
449447003616	salt bridge; other site
449447003617	sequence-specific DNA binding site [nucleotide binding]; other site
449447003618	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447003619	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447003620	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447003621	Ricin-type beta-trefoil; Region: RICIN; smart00458
449447003622	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
449447003623	putative sugar binding sites [chemical binding]; other site
449447003624	Q-X-W motif; other site
449447003625	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
449447003626	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447003627	YcfA-like protein; Region: YcfA; pfam07927
449447003628	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447003629	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
449447003630	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447003631	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
449447003632	D1 interface; other site
449447003633	chlorophyll binding site; other site
449447003634	pheophytin binding site; other site
449447003635	beta carotene binding site; other site
449447003636	cytochrome b559 beta interface; other site
449447003637	quinone binding site; other site
449447003638	cytochrome b559 alpha interface; other site
449447003639	protein J interface; other site
449447003640	protein H interface; other site
449447003641	protein X interface; other site
449447003642	core light harvesting protein interface; other site
449447003643	protein L interface; other site
449447003644	CP43 interface; other site
449447003645	protein T interface; other site
449447003646	Fe binding site [ion binding]; other site
449447003647	protein M interface; other site
449447003648	Mn-stabilizing polypeptide interface; other site
449447003649	bromide binding site; other site
449447003650	cytochrome c-550 interface; other site
449447003651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447003652	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447003653	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
449447003654	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447003655	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447003656	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003657	DDE superfamily endonuclease; Region: DDE_4; cl17710
449447003658	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447003659	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447003660	metal-binding site [ion binding]
449447003661	DNA polymerase I; Provisional; Region: PRK05755
449447003662	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
449447003663	active site
449447003664	metal binding site 1 [ion binding]; metal-binding site
449447003665	putative 5' ssDNA interaction site; other site
449447003666	metal binding site 3; metal-binding site
449447003667	metal binding site 2 [ion binding]; metal-binding site
449447003668	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
449447003669	putative DNA binding site [nucleotide binding]; other site
449447003670	putative metal binding site [ion binding]; other site
449447003671	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
449447003672	active site
449447003673	catalytic site [active]
449447003674	substrate binding site [chemical binding]; other site
449447003675	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
449447003676	active site
449447003677	DNA binding site [nucleotide binding]
449447003678	catalytic site [active]
449447003679	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447003680	putative active site [active]
449447003681	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447003682	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
449447003683	NAD binding site [chemical binding]; other site
449447003684	putative substrate binding site 2 [chemical binding]; other site
449447003685	putative substrate binding site 1 [chemical binding]; other site
449447003686	active site
449447003687	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
449447003688	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
449447003689	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
449447003690	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
449447003691	tellurium resistance terB-like protein; Region: terB_like; cd07177
449447003692	metal binding site [ion binding]; metal-binding site
449447003693	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
449447003694	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
449447003695	high affinity sulphate transporter 1; Region: sulP; TIGR00815
449447003696	Sulfate transporter family; Region: Sulfate_transp; pfam00916
449447003697	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
449447003698	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447003699	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003700	putative active site [active]
449447003701	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003702	putative active site [active]
449447003703	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
449447003704	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
449447003705	homodimer interface [polypeptide binding]; other site
449447003706	Walker A motif; other site
449447003707	ATP binding site [chemical binding]; other site
449447003708	hydroxycobalamin binding site [chemical binding]; other site
449447003709	Walker B motif; other site
449447003710	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
449447003711	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447003712	active site
449447003713	catalytic tetrad [active]
449447003714	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
449447003715	active site
449447003716	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
449447003717	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
449447003718	Walker A/P-loop; other site
449447003719	ATP binding site [chemical binding]; other site
449447003720	Q-loop/lid; other site
449447003721	ABC transporter signature motif; other site
449447003722	Walker B; other site
449447003723	D-loop; other site
449447003724	H-loop/switch region; other site
449447003725	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
449447003726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003727	dimer interface [polypeptide binding]; other site
449447003728	conserved gate region; other site
449447003729	putative PBP binding loops; other site
449447003730	ABC-ATPase subunit interface; other site
449447003731	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
449447003732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003733	dimer interface [polypeptide binding]; other site
449447003734	conserved gate region; other site
449447003735	ABC-ATPase subunit interface; other site
449447003736	PBP superfamily domain; Region: PBP_like_2; cl17296
449447003737	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
449447003738	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
449447003739	Walker A/P-loop; other site
449447003740	ATP binding site [chemical binding]; other site
449447003741	Q-loop/lid; other site
449447003742	ABC transporter signature motif; other site
449447003743	Walker B; other site
449447003744	D-loop; other site
449447003745	H-loop/switch region; other site
449447003746	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
449447003747	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
449447003748	Walker A/P-loop; other site
449447003749	ATP binding site [chemical binding]; other site
449447003750	Q-loop/lid; other site
449447003751	ABC transporter signature motif; other site
449447003752	Walker B; other site
449447003753	D-loop; other site
449447003754	H-loop/switch region; other site
449447003755	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
449447003756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003757	dimer interface [polypeptide binding]; other site
449447003758	conserved gate region; other site
449447003759	putative PBP binding loops; other site
449447003760	ABC-ATPase subunit interface; other site
449447003761	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
449447003762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003763	dimer interface [polypeptide binding]; other site
449447003764	conserved gate region; other site
449447003765	putative PBP binding loops; other site
449447003766	ABC-ATPase subunit interface; other site
449447003767	PBP superfamily domain; Region: PBP_like_2; cl17296
449447003768	PBP superfamily domain; Region: PBP_like_2; cl17296
449447003769	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
449447003770	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003771	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
449447003772	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
449447003773	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447003774	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447003775	non-specific DNA interactions [nucleotide binding]; other site
449447003776	DNA binding site [nucleotide binding]
449447003777	sequence specific DNA binding site [nucleotide binding]; other site
449447003778	putative cAMP binding site [chemical binding]; other site
449447003779	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
449447003780	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
449447003781	nucleotide binding site [chemical binding]; other site
449447003782	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003783	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447003784	Phosphotransferase enzyme family; Region: APH; pfam01636
449447003785	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
449447003786	active site
449447003787	ATP binding site [chemical binding]; other site
449447003788	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
449447003789	dimer interface [polypeptide binding]; other site
449447003790	catalytic triad [active]
449447003791	Haemolysin XhlA; Region: XhlA; pfam10779
449447003792	FOG: CBS domain [General function prediction only]; Region: COG0517
449447003793	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
449447003794	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003795	putative active site [active]
449447003796	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
449447003797	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
449447003798	dimerization interface [polypeptide binding]; other site
449447003799	active site
449447003800	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
449447003801	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
449447003802	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447003803	Coenzyme A binding pocket [chemical binding]; other site
449447003804	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447003805	active site
449447003806	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
449447003807	Stage II sporulation protein; Region: SpoIID; pfam08486
449447003808	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447003809	TrkA-N domain; Region: TrkA_N; pfam02254
449447003810	TrkA-C domain; Region: TrkA_C; pfam02080
449447003811	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
449447003812	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
449447003813	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003814	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447003815	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
449447003816	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
449447003817	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
449447003818	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
449447003819	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
449447003820	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
449447003821	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003822	putative active site [active]
449447003823	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447003824	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447003825	P-loop; other site
449447003826	Magnesium ion binding site [ion binding]; other site
449447003827	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447003828	Magnesium ion binding site [ion binding]; other site
449447003829	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447003830	ABC1 family; Region: ABC1; cl17513
449447003831	anthranilate synthase component I-like protein; Validated; Region: PRK05940
449447003832	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
449447003833	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
449447003834	Predicted permease; Region: DUF318; cl17795
449447003835	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447003836	agmatinase; Region: agmatinase; TIGR01230
449447003837	Agmatinase-like family; Region: Agmatinase-like; cd09990
449447003838	active site
449447003839	oligomer interface [polypeptide binding]; other site
449447003840	Mn binding site [ion binding]; other site
449447003841	hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100
449447003842	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
449447003843	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
449447003844	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
449447003845	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
449447003846	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447003847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447003848	dimer interface [polypeptide binding]; other site
449447003849	conserved gate region; other site
449447003850	putative PBP binding loops; other site
449447003851	ABC-ATPase subunit interface; other site
449447003852	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
449447003853	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447003854	Walker A/P-loop; other site
449447003855	ATP binding site [chemical binding]; other site
449447003856	Q-loop/lid; other site
449447003857	ABC transporter signature motif; other site
449447003858	Walker B; other site
449447003859	D-loop; other site
449447003860	H-loop/switch region; other site
449447003861	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
449447003862	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
449447003863	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
449447003864	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
449447003865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
449447003866	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447003867	DALR anticodon binding domain; Region: DALR_1; smart00836
449447003868	anticodon binding site; other site
449447003869	tRNA binding surface [nucleotide binding]; other site
449447003870	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447003871	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447003872	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447003873	large terminase protein; Provisional; Region: 17; PHA02533
449447003874	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447003875	putative active site [active]
449447003876	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447003877	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
449447003878	putative ADP-binding pocket [chemical binding]; other site
449447003879	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
449447003880	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
449447003881	Tetramer interface [polypeptide binding]; other site
449447003882	active site
449447003883	FMN-binding site [chemical binding]; other site
449447003884	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
449447003885	YacP-like NYN domain; Region: NYN_YacP; pfam05991
449447003886	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447003887	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
449447003888	Walker A/P-loop; other site
449447003889	ATP binding site [chemical binding]; other site
449447003890	Q-loop/lid; other site
449447003891	ABC transporter signature motif; other site
449447003892	Walker B; other site
449447003893	D-loop; other site
449447003894	H-loop/switch region; other site
449447003895	hypothetical protein; Provisional; Region: PRK13683
449447003896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447003897	S-adenosylmethionine binding site [chemical binding]; other site
449447003898	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
449447003899	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447003900	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447003901	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
449447003902	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
449447003903	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
449447003904	cytochrome b subunit interaction site [polypeptide binding]; other site
449447003905	[2Fe-2S] cluster binding site [ion binding]; other site
449447003906	apocytochrome f; Reviewed; Region: PRK02693
449447003907	cytochrome f; Region: petA; CHL00037
449447003908	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
449447003909	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
449447003910	Substrate binding site; other site
449447003911	Cupin domain; Region: Cupin_2; cl17218
449447003912	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447003913	ABC1 family; Region: ABC1; pfam03109
449447003914	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
449447003915	active site
449447003916	ATP binding site [chemical binding]; other site
449447003917	glutamine synthetase, type I; Region: GlnA; TIGR00653
449447003918	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
449447003919	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
449447003920	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
449447003921	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447003922	tandem repeat interface [polypeptide binding]; other site
449447003923	oligomer interface [polypeptide binding]; other site
449447003924	active site residues [active]
449447003925	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
449447003926	homotrimer interaction site [polypeptide binding]; other site
449447003927	active site
449447003928	hydrolase, alpha/beta fold family protein; Region: PLN02824
449447003929	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
449447003930	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447003931	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
449447003932	Peptidase family M48; Region: Peptidase_M48; cl12018
449447003933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003934	Probable transposase; Region: OrfB_IS605; pfam01385
449447003935	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003936	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
449447003937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447003938	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
449447003939	putative dimerization interface [polypeptide binding]; other site
449447003940	Domain of unknown function (DUF955); Region: DUF955; pfam06114
449447003941	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
449447003942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447003943	non-specific DNA binding site [nucleotide binding]; other site
449447003944	salt bridge; other site
449447003945	sequence-specific DNA binding site [nucleotide binding]; other site
449447003946	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
449447003947	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
449447003948	5' RNA guide strand anchoring site; other site
449447003949	active site
449447003950	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
449447003951	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
449447003952	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
449447003953	active site
449447003954	catalytic site [active]
449447003955	Uncharacterized conserved protein [Function unknown]; Region: COG0398
449447003956	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
449447003957	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447003958	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
449447003959	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447003960	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
449447003961	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
449447003962	dimer interface [polypeptide binding]; other site
449447003963	active site
449447003964	CoA binding pocket [chemical binding]; other site
449447003965	putative phosphate acyltransferase; Provisional; Region: PRK05331
449447003966	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
449447003967	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
449447003968	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447003969	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
449447003970	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
449447003971	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
449447003972	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
449447003973	Predicted membrane protein [Function unknown]; Region: COG1808
449447003974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447003975	Probable transposase; Region: OrfB_IS605; pfam01385
449447003976	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447003977	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
449447003978	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
449447003979	5S rRNA interface [nucleotide binding]; other site
449447003980	CTC domain interface [polypeptide binding]; other site
449447003981	L16 interface [polypeptide binding]; other site
449447003982	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
449447003983	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
449447003984	GDP-binding site [chemical binding]; other site
449447003985	ACT binding site; other site
449447003986	IMP binding site; other site
449447003987	Predicted permeases [General function prediction only]; Region: COG0795
449447003988	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
449447003989	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
449447003990	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
449447003991	active site
449447003992	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
449447003993	chaperone protein DnaJ; Provisional; Region: PRK14299
449447003994	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447003995	HSP70 interaction site [polypeptide binding]; other site
449447003996	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447003997	substrate binding site [polypeptide binding]; other site
449447003998	dimer interface [polypeptide binding]; other site
449447003999	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447004000	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004001	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004002	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004003	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447004004	MASE1; Region: MASE1; pfam05231
449447004005	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447004006	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447004007	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447004008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447004009	dimer interface [polypeptide binding]; other site
449447004010	phosphorylation site [posttranslational modification]
449447004011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447004012	ATP binding site [chemical binding]; other site
449447004013	Mg2+ binding site [ion binding]; other site
449447004014	G-X-G motif; other site
449447004015	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447004016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004017	active site
449447004018	phosphorylation site [posttranslational modification]
449447004019	intermolecular recognition site; other site
449447004020	dimerization interface [polypeptide binding]; other site
449447004021	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447004022	DNA binding residues [nucleotide binding]
449447004023	dimerization interface [polypeptide binding]; other site
449447004024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447004025	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004026	putative active site [active]
449447004027	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004028	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447004029	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004030	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004031	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004032	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447004033	dinuclear metal binding motif [ion binding]; other site
449447004034	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447004035	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004036	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004037	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004038	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447004039	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
449447004040	active site
449447004041	Zn2+ binding site [ion binding]; other site
449447004042	argininosuccinate lyase; Provisional; Region: PRK00855
449447004043	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
449447004044	active sites [active]
449447004045	tetramer interface [polypeptide binding]; other site
449447004046	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
449447004047	nudix motif; other site
449447004048	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447004049	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
449447004050	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447004051	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447004052	active site
449447004053	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
449447004054	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
449447004055	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447004056	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447004057	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447004058	putative active site [active]
449447004059	putative NTP binding site [chemical binding]; other site
449447004060	putative nucleic acid binding site [nucleotide binding]; other site
449447004061	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447004062	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447004063	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447004064	active site
449447004065	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447004066	NMT1-like family; Region: NMT1_2; pfam13379
449447004067	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447004068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
449447004069	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447004070	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447004071	Walker A/P-loop; other site
449447004072	ATP binding site [chemical binding]; other site
449447004073	Q-loop/lid; other site
449447004074	ABC transporter signature motif; other site
449447004075	Walker B; other site
449447004076	D-loop; other site
449447004077	H-loop/switch region; other site
449447004078	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447004079	NMT1-like family; Region: NMT1_2; pfam13379
449447004080	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447004081	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
449447004082	Walker A/P-loop; other site
449447004083	ATP binding site [chemical binding]; other site
449447004084	Q-loop/lid; other site
449447004085	ABC transporter signature motif; other site
449447004086	Walker B; other site
449447004087	D-loop; other site
449447004088	H-loop/switch region; other site
449447004089	Predicted membrane protein [Function unknown]; Region: COG3431
449447004090	Bacterial SH3 domain; Region: SH3_3; cl17532
449447004091	Ycf46; Provisional; Region: ycf46; CHL00195
449447004092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447004093	Walker A motif; other site
449447004094	ATP binding site [chemical binding]; other site
449447004095	Walker B motif; other site
449447004096	arginine finger; other site
449447004097	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
449447004098	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447004099	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
449447004100	inhibitor-cofactor binding pocket; inhibition site
449447004101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447004102	catalytic residue [active]
449447004103	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447004104	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
449447004105	Ligand binding site; other site
449447004106	Putative Catalytic site; other site
449447004107	DXD motif; other site
449447004108	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447004109	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447004110	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
449447004111	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
449447004112	homodimer interface [polypeptide binding]; other site
449447004113	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
449447004114	active site pocket [active]
449447004115	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
449447004116	XisH protein; Region: XisH; pfam08814
449447004117	XisI protein; Region: XisI; pfam08869
449447004118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447004119	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447004120	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004121	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004122	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004123	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447004124	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
449447004125	putative metal binding site [ion binding]; other site
449447004126	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
449447004127	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004128	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004129	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004130	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004131	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004132	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447004133	HSP70 interaction site [polypeptide binding]; other site
449447004134	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447004135	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447004136	active site
449447004137	ATP binding site [chemical binding]; other site
449447004138	substrate binding site [chemical binding]; other site
449447004139	activation loop (A-loop); other site
449447004140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004141	Probable transposase; Region: OrfB_IS605; pfam01385
449447004142	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447004143	putative active site [active]
449447004144	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
449447004145	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447004146	Putative addiction module component; Region: Unstab_antitox; cl09921
449447004147	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004148	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447004149	DNA-binding interface [nucleotide binding]; DNA binding site
449447004150	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004152	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447004153	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004154	putative active site [active]
449447004155	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004156	putative active site [active]
449447004157	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
449447004158	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
449447004159	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
449447004160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447004161	Walker A/P-loop; other site
449447004162	ATP binding site [chemical binding]; other site
449447004163	Q-loop/lid; other site
449447004164	ABC transporter signature motif; other site
449447004165	Walker B; other site
449447004166	D-loop; other site
449447004167	H-loop/switch region; other site
449447004168	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
449447004169	active site
449447004170	hydrolase, alpha/beta fold family protein; Region: PLN02824
449447004171	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
449447004172	catalytic site [active]
449447004173	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004174	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
449447004175	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447004177	Walker A/P-loop; other site
449447004178	ATP binding site [chemical binding]; other site
449447004179	AAA domain; Region: AAA_21; pfam13304
449447004180	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004182	Paired Box domain; Region: PAX; cd00131
449447004183	DNA binding site [nucleotide binding]
449447004184	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004185	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004187	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004188	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447004189	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004190	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447004191	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447004192	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447004193	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
449447004194	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
449447004195	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
449447004196	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
449447004197	putative metal binding residues [ion binding]; other site
449447004198	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
449447004199	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
449447004200	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447004201	ATP binding site [chemical binding]; other site
449447004202	putative Mg++ binding site [ion binding]; other site
449447004203	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447004204	nucleotide binding region [chemical binding]; other site
449447004205	ATP-binding site [chemical binding]; other site
449447004206	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
449447004207	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004208	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447004209	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
449447004210	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004211	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004213	TPR motif; other site
449447004214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004215	binding surface
449447004216	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004217	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004218	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004219	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004220	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004221	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004222	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447004223	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447004224	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004225	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004226	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004227	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004228	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004229	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004230	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004232	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004233	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447004234	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
449447004235	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
449447004236	substrate binding site [chemical binding]; other site
449447004237	active site
449447004238	catalytic residues [active]
449447004239	heterodimer interface [polypeptide binding]; other site
449447004240	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447004241	putative metal binding site; other site
449447004242	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447004243	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447004244	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004245	Integrase core domain; Region: rve; pfam00665
449447004246	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447004247	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447004248	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004249	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004250	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004251	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447004252	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004253	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004254	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447004255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004256	dimer interface [polypeptide binding]; other site
449447004257	conserved gate region; other site
449447004258	putative PBP binding loops; other site
449447004259	ABC-ATPase subunit interface; other site
449447004260	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
449447004261	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447004262	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
449447004263	active site
449447004264	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447004265	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
449447004266	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
449447004267	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447004268	catalytic residue [active]
449447004269	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
449447004270	Amidinotransferase; Region: Amidinotransf; cl12043
449447004271	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
449447004272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447004273	short chain dehydrogenase; Validated; Region: PRK06182
449447004274	NAD(P) binding site [chemical binding]; other site
449447004275	active site
449447004276	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
449447004277	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
449447004278	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447004279	DevC protein; Region: devC; TIGR01185
449447004280	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447004281	FtsX-like permease family; Region: FtsX; pfam02687
449447004282	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
449447004283	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
449447004284	Walker A/P-loop; other site
449447004285	ATP binding site [chemical binding]; other site
449447004286	Q-loop/lid; other site
449447004287	ABC transporter signature motif; other site
449447004288	Walker B; other site
449447004289	D-loop; other site
449447004290	H-loop/switch region; other site
449447004291	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004292	Radical SAM superfamily; Region: Radical_SAM; pfam04055
449447004293	FeS/SAM binding site; other site
449447004294	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
449447004295	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
449447004296	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
449447004297	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
449447004298	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
449447004299	substrate binding site [chemical binding]; other site
449447004300	catalytic Zn binding site [ion binding]; other site
449447004301	NAD binding site [chemical binding]; other site
449447004302	structural Zn binding site [ion binding]; other site
449447004303	dimer interface [polypeptide binding]; other site
449447004304	CHAT domain; Region: CHAT; cl17868
449447004305	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004308	binding surface
449447004309	TPR motif; other site
449447004310	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004312	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004313	TIR domain; Region: TIR_2; pfam13676
449447004314	TIR domain; Region: TIR_2; pfam13676
449447004315	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447004316	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447004317	Stage II sporulation protein; Region: SpoIID; pfam08486
449447004318	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
449447004319	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
449447004320	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
449447004321	substrate binding pocket [chemical binding]; other site
449447004322	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
449447004323	B12 binding site [chemical binding]; other site
449447004324	cobalt ligand [ion binding]; other site
449447004325	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
449447004326	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
449447004327	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
449447004328	NAD binding site [chemical binding]; other site
449447004329	dimerization interface [polypeptide binding]; other site
449447004330	product binding site; other site
449447004331	substrate binding site [chemical binding]; other site
449447004332	zinc binding site [ion binding]; other site
449447004333	catalytic residues [active]
449447004334	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
449447004335	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
449447004336	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
449447004337	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
449447004338	shikimate kinase; Reviewed; Region: aroK; PRK00131
449447004339	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
449447004340	ADP binding site [chemical binding]; other site
449447004341	magnesium binding site [ion binding]; other site
449447004342	putative shikimate binding site; other site
449447004343	Cupin domain; Region: Cupin_2; cl17218
449447004344	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
449447004345	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004346	FeS/SAM binding site; other site
449447004347	HemN C-terminal domain; Region: HemN_C; pfam06969
449447004348	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
449447004349	von Willebrand factor type D domain; Region: VWD; cl02516
449447004350	Calx-beta domain; Region: Calx-beta; pfam03160
449447004351	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
449447004352	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
449447004353	putative active site [active]
449447004354	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
449447004355	Glucose inhibited division protein A; Region: GIDA; pfam01134
449447004356	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
449447004357	MutS domain I; Region: MutS_I; pfam01624
449447004358	MutS domain II; Region: MutS_II; pfam05188
449447004359	MutS domain III; Region: MutS_III; pfam05192
449447004360	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
449447004361	Walker A/P-loop; other site
449447004362	ATP binding site [chemical binding]; other site
449447004363	Q-loop/lid; other site
449447004364	ABC transporter signature motif; other site
449447004365	Walker B; other site
449447004366	D-loop; other site
449447004367	H-loop/switch region; other site
449447004368	Phycobilisome protein; Region: Phycobilisome; cl08227
449447004369	gamma-glutamyl kinase; Provisional; Region: PRK05429
449447004370	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
449447004371	nucleotide binding site [chemical binding]; other site
449447004372	homotetrameric interface [polypeptide binding]; other site
449447004373	putative phosphate binding site [ion binding]; other site
449447004374	putative allosteric binding site; other site
449447004375	PUA domain; Region: PUA; pfam01472
449447004376	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
449447004377	DHH family; Region: DHH; pfam01368
449447004378	DHHA1 domain; Region: DHHA1; pfam02272
449447004379	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447004380	GAF domain; Region: GAF; pfam01590
449447004381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447004382	dimer interface [polypeptide binding]; other site
449447004383	phosphorylation site [posttranslational modification]
449447004384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447004385	ATP binding site [chemical binding]; other site
449447004386	Mg2+ binding site [ion binding]; other site
449447004387	G-X-G motif; other site
449447004388	Response regulator receiver domain; Region: Response_reg; pfam00072
449447004389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004390	active site
449447004391	phosphorylation site [posttranslational modification]
449447004392	intermolecular recognition site; other site
449447004393	dimerization interface [polypeptide binding]; other site
449447004394	Repair protein; Region: Repair_PSII; pfam04536
449447004395	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447004396	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447004397	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
449447004398	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
449447004399	active site
449447004400	homodimer interface [polypeptide binding]; other site
449447004401	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004402	putative active site [active]
449447004403	Phosphotransferase enzyme family; Region: APH; pfam01636
449447004404	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
449447004405	active site
449447004406	ATP binding site [chemical binding]; other site
449447004407	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
449447004408	substrate binding site [chemical binding]; other site
449447004409	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
449447004410	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
449447004411	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
449447004412	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447004413	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447004414	XisI protein; Region: XisI; pfam08869
449447004415	XisH protein; Region: XisH; pfam08814
449447004416	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447004417	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447004418	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447004419	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447004420	active site
449447004421	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004422	putative active site [active]
449447004423	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447004424	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
449447004425	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004426	putative active site [active]
449447004427	ABC-2 type transporter; Region: ABC2_membrane; cl17235
449447004428	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
449447004429	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
449447004430	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447004431	P loop; other site
449447004432	Nucleotide binding site [chemical binding]; other site
449447004433	DTAP/Switch II; other site
449447004434	Switch I; other site
449447004435	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
449447004436	putative dimer interface [polypeptide binding]; other site
449447004437	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
449447004438	UbiA prenyltransferase family; Region: UbiA; pfam01040
449447004439	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
449447004440	light-harvesting-like protein 3; Provisional; Region: PLN00014
449447004441	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
449447004442	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004443	putative active site [active]
449447004444	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004445	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004446	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004447	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004448	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004449	DNA repair protein RadA; Provisional; Region: PRK11823
449447004450	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
449447004451	Walker A motif/ATP binding site; other site
449447004452	ATP binding site [chemical binding]; other site
449447004453	Walker B motif; other site
449447004454	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
449447004455	Ycf27; Reviewed; Region: orf27; CHL00148
449447004456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004457	active site
449447004458	phosphorylation site [posttranslational modification]
449447004459	intermolecular recognition site; other site
449447004460	dimerization interface [polypeptide binding]; other site
449447004461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447004462	DNA binding site [nucleotide binding]
449447004463	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
449447004464	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004465	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004466	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004467	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004468	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004469	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004471	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004472	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004473	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447004474	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004475	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447004476	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004477	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004478	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004479	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004480	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447004481	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447004482	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004483	Integrase core domain; Region: rve; pfam00665
449447004484	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447004485	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004486	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004487	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004488	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004489	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447004490	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447004492	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447004493	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
449447004494	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
449447004495	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
449447004496	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004497	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004498	Winged helix-turn helix; Region: HTH_33; pfam13592
449447004499	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004500	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004501	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004502	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004503	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004505	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447004506	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
449447004507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447004508	S-adenosylmethionine binding site [chemical binding]; other site
449447004509	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004510	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447004511	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447004512	Putative methyltransferase; Region: Methyltransf_20; pfam12147
449447004513	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447004514	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447004515	putative acyl-acceptor binding pocket; other site
449447004516	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
449447004517	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
449447004518	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
449447004519	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447004520	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004521	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004522	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004523	TMAO/DMSO reductase; Reviewed; Region: PRK05363
449447004524	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
449447004525	Moco binding site; other site
449447004526	metal coordination site [ion binding]; other site
449447004527	Cytochrome P450; Region: p450; pfam00067
449447004528	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
449447004529	Uncharacterized conserved protein [Function unknown]; Region: COG0398
449447004530	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
449447004531	mercuric reductase; Validated; Region: PRK06370
449447004532	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447004533	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447004534	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447004535	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447004536	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447004537	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447004538	Homeodomain-like domain; Region: HTH_23; pfam13384
449447004539	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004540	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004541	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004542	YcfA-like protein; Region: YcfA; cl00752
449447004543	YcfA-like protein; Region: YcfA; cl00752
449447004544	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447004545	PemK-like protein; Region: PemK; pfam02452
449447004546	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
449447004547	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447004548	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447004549	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447004550	Protein kinase domain; Region: Pkinase; pfam00069
449447004551	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447004552	active site
449447004553	ATP binding site [chemical binding]; other site
449447004554	substrate binding site [chemical binding]; other site
449447004555	activation loop (A-loop); other site
449447004556	AAA ATPase domain; Region: AAA_16; pfam13191
449447004557	Predicted ATPase [General function prediction only]; Region: COG3899
449447004558	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447004559	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447004560	PAS fold; Region: PAS_4; pfam08448
449447004561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
449447004562	putative active site [active]
449447004563	heme pocket [chemical binding]; other site
449447004564	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
449447004565	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
449447004566	catalytic residues [active]
449447004567	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
449447004568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004569	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004570	Probable transposase; Region: OrfB_IS605; pfam01385
449447004571	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004572	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
449447004573	dimer interface [polypeptide binding]; other site
449447004574	allosteric magnesium binding site [ion binding]; other site
449447004575	active site
449447004576	aspartate-rich active site metal binding site; other site
449447004577	Schiff base residues; other site
449447004578	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
449447004579	homodecamer interface [polypeptide binding]; other site
449447004580	GTP cyclohydrolase I; Provisional; Region: PLN03044
449447004581	active site
449447004582	putative catalytic site residues [active]
449447004583	zinc binding site [ion binding]; other site
449447004584	GTP-CH-I/GFRP interaction surface; other site
449447004585	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
449447004586	active site
449447004587	catalytic residues [active]
449447004588	metal binding site [ion binding]; metal-binding site
449447004589	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
449447004590	DnaA N-terminal domain; Region: DnaA_N; pfam11638
449447004591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447004592	Walker A motif; other site
449447004593	ATP binding site [chemical binding]; other site
449447004594	Walker B motif; other site
449447004595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
449447004596	arginine finger; other site
449447004597	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
449447004598	DnaA box-binding interface [nucleotide binding]; other site
449447004599	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
449447004600	UbiA prenyltransferase family; Region: UbiA; pfam01040
449447004601	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
449447004602	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
449447004603	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
449447004604	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
449447004605	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
449447004606	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
449447004607	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
449447004608	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
449447004609	Subunit I/III interface [polypeptide binding]; other site
449447004610	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447004611	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
449447004612	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
449447004613	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
449447004614	active site
449447004615	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004616	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004617	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447004618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447004619	S-adenosylmethionine binding site [chemical binding]; other site
449447004620	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
449447004621	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
449447004622	active site
449447004623	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447004624	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
449447004625	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447004626	catalytic residue [active]
449447004627	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
449447004628	FeS assembly protein SufD; Region: sufD; TIGR01981
449447004629	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
449447004630	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
449447004631	Walker A/P-loop; other site
449447004632	ATP binding site [chemical binding]; other site
449447004633	Q-loop/lid; other site
449447004634	ABC transporter signature motif; other site
449447004635	Walker B; other site
449447004636	D-loop; other site
449447004637	H-loop/switch region; other site
449447004638	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
449447004639	putative ABC transporter; Region: ycf24; CHL00085
449447004640	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
449447004641	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
449447004642	putative DNA binding site [nucleotide binding]; other site
449447004643	putative Zn2+ binding site [ion binding]; other site
449447004644	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004645	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004646	Probable transposase; Region: OrfB_IS605; pfam01385
449447004647	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004648	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
449447004649	CAAX protease self-immunity; Region: Abi; pfam02517
449447004650	putative glycosyl transferase; Provisional; Region: PRK10307
449447004651	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
449447004652	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
449447004653	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
449447004654	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
449447004655	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
449447004656	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004657	Probable transposase; Region: OrfB_IS605; pfam01385
449447004658	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004659	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
449447004660	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447004661	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447004662	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447004663	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447004664	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447004665	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447004666	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
449447004667	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
449447004668	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447004669	ATP binding site [chemical binding]; other site
449447004670	putative Mg++ binding site [ion binding]; other site
449447004671	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447004672	nucleotide binding region [chemical binding]; other site
449447004673	ATP-binding site [chemical binding]; other site
449447004674	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
449447004675	putative RNA binding site [nucleotide binding]; other site
449447004676	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
449447004677	putative active site [active]
449447004678	putative metal binding residues [ion binding]; other site
449447004679	signature motif; other site
449447004680	putative dimer interface [polypeptide binding]; other site
449447004681	putative phosphate binding site [ion binding]; other site
449447004682	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
449447004683	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447004684	dimer interface [polypeptide binding]; other site
449447004685	active site
449447004686	glutathione binding site [chemical binding]; other site
449447004687	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004688	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
449447004689	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
449447004690	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
449447004691	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
449447004692	PsaD; Region: PsaD; pfam02531
449447004693	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
449447004694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004695	ABC-ATPase subunit interface; other site
449447004696	putative PBP binding loops; other site
449447004697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447004698	dimer interface [polypeptide binding]; other site
449447004699	conserved gate region; other site
449447004700	putative PBP binding loops; other site
449447004701	ABC-ATPase subunit interface; other site
449447004702	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
449447004703	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
449447004704	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
449447004705	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
449447004706	glutamine binding [chemical binding]; other site
449447004707	catalytic triad [active]
449447004708	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447004709	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004710	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447004711	Transcriptional regulator [Transcription]; Region: LytR; COG1316
449447004712	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
449447004713	NlpC/P60 family; Region: NLPC_P60; pfam00877
449447004714	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
449447004715	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
449447004716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004717	Probable transposase; Region: OrfB_IS605; pfam01385
449447004718	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004719	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447004720	Winged helix-turn helix; Region: HTH_29; pfam13551
449447004721	Homeodomain-like domain; Region: HTH_32; pfam13565
449447004722	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004723	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447004724	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447004725	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447004726	Calx-beta domain; Region: Calx-beta; cl02522
449447004727	Calx-beta domain; Region: Calx-beta; cl02522
449447004728	Calx-beta domain; Region: Calx-beta; cl02522
449447004729	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447004730	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
449447004731	MutS domain III; Region: MutS_III; pfam05192
449447004732	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447004733	Walker A/P-loop; other site
449447004734	ATP binding site [chemical binding]; other site
449447004735	Q-loop/lid; other site
449447004736	ABC transporter signature motif; other site
449447004737	Walker B; other site
449447004738	D-loop; other site
449447004739	H-loop/switch region; other site
449447004740	Smr domain; Region: Smr; pfam01713
449447004741	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
449447004742	CHASE3 domain; Region: CHASE3; pfam05227
449447004743	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447004744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447004745	dimer interface [polypeptide binding]; other site
449447004746	phosphorylation site [posttranslational modification]
449447004747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447004748	ATP binding site [chemical binding]; other site
449447004749	G-X-G motif; other site
449447004750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447004751	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447004752	Probable transposase; Region: OrfB_IS605; pfam01385
449447004753	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447004754	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447004755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447004756	active site
449447004757	phosphorylation site [posttranslational modification]
449447004758	intermolecular recognition site; other site
449447004759	dimerization interface [polypeptide binding]; other site
449447004760	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447004761	DNA binding site [nucleotide binding]
449447004762	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004763	putative active site [active]
449447004764	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
449447004765	NADH(P)-binding; Region: NAD_binding_10; pfam13460
449447004766	NAD(P) binding site [chemical binding]; other site
449447004767	putative active site [active]
449447004768	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
449447004769	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
449447004770	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
449447004771	G1 box; other site
449447004772	putative GEF interaction site [polypeptide binding]; other site
449447004773	GTP/Mg2+ binding site [chemical binding]; other site
449447004774	Switch I region; other site
449447004775	G2 box; other site
449447004776	G3 box; other site
449447004777	Switch II region; other site
449447004778	G4 box; other site
449447004779	G5 box; other site
449447004780	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
449447004781	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
449447004782	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
449447004783	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
449447004784	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447004785	active site
449447004786	TIGR04255 family protein; Region: sporadTIGR04255
449447004787	Helix-turn-helix; Region: HTH_3; pfam01381
449447004788	non-specific DNA binding site [nucleotide binding]; other site
449447004789	salt bridge; other site
449447004790	sequence-specific DNA binding site [nucleotide binding]; other site
449447004791	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447004792	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447004793	Catalytic site [active]
449447004794	4Fe-4S binding domain; Region: Fer4_5; pfam12801
449447004795	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
449447004796	EF-hand domain pair; Region: EF_hand_5; pfam13499
449447004797	Ca2+ binding site [ion binding]; other site
449447004798	Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396
449447004799	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
449447004800	Family description; Region: UvrD_C_2; pfam13538
449447004801	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
449447004802	hypothetical protein; Provisional; Region: PRK07377
449447004803	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
449447004804	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004805	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447004806	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
449447004807	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004808	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447004809	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
449447004810	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
449447004811	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447004812	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447004813	putative active site [active]
449447004814	TIGR02646 family protein; Region: TIGR02646
449447004815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447004816	Walker A/P-loop; other site
449447004817	ATP binding site [chemical binding]; other site
449447004818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447004819	Walker A/P-loop; other site
449447004820	ATP binding site [chemical binding]; other site
449447004821	Q-loop/lid; other site
449447004822	ABC transporter signature motif; other site
449447004823	Walker B; other site
449447004824	D-loop; other site
449447004825	H-loop/switch region; other site
449447004826	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
449447004827	AMP binding site [chemical binding]; other site
449447004828	metal binding site [ion binding]; metal-binding site
449447004829	active site
449447004830	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
449447004831	Exoribonuclease R [Transcription]; Region: VacB; COG0557
449447004832	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
449447004833	RNB domain; Region: RNB; pfam00773
449447004834	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
449447004835	RNA binding site [nucleotide binding]; other site
449447004836	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
449447004837	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
449447004838	hypothetical protein; Validated; Region: PRK00153
449447004839	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
449447004840	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
449447004841	PLD-like domain; Region: PLDc_2; pfam13091
449447004842	putative active site [active]
449447004843	catalytic site [active]
449447004844	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
449447004845	PLD-like domain; Region: PLDc_2; pfam13091
449447004846	putative active site [active]
449447004847	catalytic site [active]
449447004848	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447004849	Helix-hairpin-helix motif; Region: HHH; pfam00633
449447004850	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
449447004851	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447004852	G1 box; other site
449447004853	GTP/Mg2+ binding site [chemical binding]; other site
449447004854	G2 box; other site
449447004855	Switch I region; other site
449447004856	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447004857	G3 box; other site
449447004858	Switch II region; other site
449447004859	G4 box; other site
449447004860	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447004861	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447004862	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004863	putative active site [active]
449447004864	Predicted permeases [General function prediction only]; Region: COG0679
449447004865	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004866	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447004867	DNA-binding interface [nucleotide binding]; DNA binding site
449447004868	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004870	O-Antigen ligase; Region: Wzy_C; pfam04932
449447004871	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
449447004872	O-Antigen ligase; Region: Wzy_C; cl04850
449447004873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
449447004874	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
449447004875	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447004876	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447004877	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
449447004878	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
449447004879	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447004880	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
449447004881	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
449447004882	ATP-grasp domain; Region: ATP-grasp_4; cl17255
449447004883	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
449447004884	ATP-grasp domain; Region: ATP-grasp_4; cl17255
449447004885	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
449447004886	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
449447004887	antiporter inner membrane protein; Provisional; Region: PRK11670
449447004888	Domain of unknown function DUF59; Region: DUF59; pfam01883
449447004889	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
449447004890	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
449447004891	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
449447004892	MOSC domain; Region: MOSC; pfam03473
449447004893	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004894	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447004895	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447004896	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447004897	amidase; Provisional; Region: PRK09201
449447004898	Amidase; Region: Amidase; cl11426
449447004899	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447004900	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447004901	B12 binding site [chemical binding]; other site
449447004902	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447004903	FeS/SAM binding site; other site
449447004904	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447004905	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447004906	putative ligand binding site [chemical binding]; other site
449447004907	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
449447004908	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
449447004909	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447004910	Maf-like protein; Region: Maf; pfam02545
449447004911	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
449447004912	active site
449447004913	dimer interface [polypeptide binding]; other site
449447004914	PsbP; Region: PsbP; pfam01789
449447004915	TPR repeat; Region: TPR_11; pfam13414
449447004916	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004917	binding surface
449447004918	TPR motif; other site
449447004919	TPR repeat; Region: TPR_11; pfam13414
449447004920	TPR repeat; Region: TPR_11; pfam13414
449447004921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004922	binding surface
449447004923	TPR motif; other site
449447004924	TPR repeat; Region: TPR_11; pfam13414
449447004925	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447004926	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447004927	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
449447004928	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
449447004929	active site
449447004930	HIGH motif; other site
449447004931	dimer interface [polypeptide binding]; other site
449447004932	KMSKS motif; other site
449447004933	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447004934	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004935	putative active site [active]
449447004936	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
449447004937	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
449447004938	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447004939	RNA binding surface [nucleotide binding]; other site
449447004940	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447004941	YcfA-like protein; Region: YcfA; pfam07927
449447004942	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447004943	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447004944	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
449447004945	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
449447004946	feedback inhibition sensing region; other site
449447004947	homohexameric interface [polypeptide binding]; other site
449447004948	nucleotide binding site [chemical binding]; other site
449447004949	N-acetyl-L-glutamate binding site [chemical binding]; other site
449447004950	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
449447004951	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
449447004952	metal binding site [ion binding]; metal-binding site
449447004953	dimer interface [polypeptide binding]; other site
449447004954	Phycobilisome protein; Region: Phycobilisome; cl08227
449447004955	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
449447004956	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447004957	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
449447004958	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447004959	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
449447004960	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
449447004961	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
449447004962	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
449447004963	dimerization interface [polypeptide binding]; other site
449447004964	active site
449447004965	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447004966	putative active site [active]
449447004967	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
449447004968	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
449447004969	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
449447004970	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447004971	Helix-turn-helix domain; Region: HTH_18; pfam12833
449447004972	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
449447004973	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
449447004974	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
449447004975	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
449447004976	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004977	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447004978	binding surface
449447004979	TPR motif; other site
449447004980	TPR repeat; Region: TPR_11; pfam13414
449447004981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004982	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447004983	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447004984	DNA-binding interface [nucleotide binding]; DNA binding site
449447004985	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447004986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447004987	PemK-like protein; Region: PemK; pfam02452
449447004988	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447004989	TPR repeat; Region: TPR_11; pfam13414
449447004990	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004992	binding surface
449447004993	TPR motif; other site
449447004994	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447004996	binding surface
449447004997	TPR motif; other site
449447004998	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447004999	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005000	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005001	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447005002	CHAT domain; Region: CHAT; cl17868
449447005003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447005004	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447005005	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447005006	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447005007	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447005008	active site
449447005009	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005010	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447005011	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005012	binding surface
449447005013	TPR motif; other site
449447005014	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005015	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005017	binding surface
449447005018	TPR motif; other site
449447005019	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005020	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005022	binding surface
449447005023	TPR motif; other site
449447005024	CHAT domain; Region: CHAT; pfam12770
449447005025	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
449447005026	haemagglutination activity domain; Region: Haemagg_act; pfam05860
449447005027	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005028	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005029	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
449447005030	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
449447005031	Surface antigen; Region: Bac_surface_Ag; pfam01103
449447005032	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
449447005033	Caspase domain; Region: Peptidase_C14; pfam00656
449447005034	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447005035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447005036	S-adenosylmethionine binding site [chemical binding]; other site
449447005037	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
449447005038	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
449447005039	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
449447005040	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
449447005041	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447005042	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005043	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005044	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447005045	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447005046	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005047	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005048	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
449447005049	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
449447005050	HflX GTPase family; Region: HflX; cd01878
449447005051	G1 box; other site
449447005052	GTP/Mg2+ binding site [chemical binding]; other site
449447005053	Switch I region; other site
449447005054	G2 box; other site
449447005055	G3 box; other site
449447005056	Switch II region; other site
449447005057	G4 box; other site
449447005058	G5 box; other site
449447005059	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
449447005060	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447005061	inhibitor-cofactor binding pocket; inhibition site
449447005062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447005063	catalytic residue [active]
449447005064	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
449447005065	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
449447005066	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
449447005067	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
449447005068	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
449447005069	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447005070	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447005071	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447005072	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
449447005073	FAD binding domain; Region: FAD_binding_4; pfam01565
449447005074	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
449447005075	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
449447005076	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
449447005077	peptide binding site [polypeptide binding]; other site
449447005078	dimer interface [polypeptide binding]; other site
449447005079	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447005080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447005081	dimer interface [polypeptide binding]; other site
449447005082	conserved gate region; other site
449447005083	putative PBP binding loops; other site
449447005084	ABC-ATPase subunit interface; other site
449447005085	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
449447005086	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447005087	dimer interface [polypeptide binding]; other site
449447005088	putative metal binding site [ion binding]; other site
449447005089	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
449447005090	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
449447005091	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
449447005092	ResB-like family; Region: ResB; pfam05140
449447005093	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
449447005094	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
449447005095	DNA binding site [nucleotide binding]
449447005096	catalytic residue [active]
449447005097	H2TH interface [polypeptide binding]; other site
449447005098	putative catalytic residues [active]
449447005099	turnover-facilitating residue; other site
449447005100	intercalation triad [nucleotide binding]; other site
449447005101	8OG recognition residue [nucleotide binding]; other site
449447005102	putative reading head residues; other site
449447005103	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
449447005104	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
449447005105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005106	binding surface
449447005107	TPR motif; other site
449447005108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005109	binding surface
449447005110	TPR motif; other site
449447005111	TPR repeat; Region: TPR_11; pfam13414
449447005112	Predicted integral membrane protein [Function unknown]; Region: COG0392
449447005113	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447005114	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447005115	structural tetrad; other site
449447005116	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447005117	structural tetrad; other site
449447005118	DNA polymerase III subunit delta; Validated; Region: PRK07452
449447005119	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
449447005120	CHAT domain; Region: CHAT; cl17868
449447005121	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447005122	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447005123	phosphopeptide binding site; other site
449447005124	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
449447005125	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
449447005126	oligomer interface [polypeptide binding]; other site
449447005127	metal binding site [ion binding]; metal-binding site
449447005128	metal binding site [ion binding]; metal-binding site
449447005129	Cl binding site [ion binding]; other site
449447005130	aspartate ring; other site
449447005131	basic sphincter; other site
449447005132	putative hydrophobic gate; other site
449447005133	periplasmic entrance; other site
449447005134	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
449447005135	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
449447005136	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
449447005137	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
449447005138	NAD(P) binding site [chemical binding]; other site
449447005139	catalytic residues [active]
449447005140	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
449447005141	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
449447005142	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
449447005143	catalytic residue [active]
449447005144	putative FPP diphosphate  binding site; other site
449447005145	putative FPP binding hydrophobic cleft; other site
449447005146	dimer interface [polypeptide binding]; other site
449447005147	putative IPP diphosphate binding site; other site
449447005148	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
449447005149	diaminopimelate decarboxylase; Region: lysA; TIGR01048
449447005150	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
449447005151	active site
449447005152	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447005153	substrate binding site [chemical binding]; other site
449447005154	catalytic residues [active]
449447005155	dimer interface [polypeptide binding]; other site
449447005156	GUN4-like; Region: GUN4; pfam05419
449447005157	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
449447005158	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
449447005159	putative NAD(P) binding site [chemical binding]; other site
449447005160	putative active site [active]
449447005161	photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047
449447005162	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
449447005163	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
449447005164	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005165	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005166	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447005167	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447005168	DNA-binding interface [nucleotide binding]; DNA binding site
449447005169	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005171	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005172	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005173	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005174	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005175	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005176	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
449447005177	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
449447005178	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
449447005179	motif 1; other site
449447005180	active site
449447005181	motif 2; other site
449447005182	motif 3; other site
449447005183	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
449447005184	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447005185	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
449447005186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
449447005187	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
449447005188	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447005189	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
449447005190	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
449447005191	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
449447005192	Walker A motif; other site
449447005193	ATP binding site [chemical binding]; other site
449447005194	Walker B motif; other site
449447005195	DNA binding loops [nucleotide binding]
449447005196	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
449447005197	protein-splicing catalytic site; other site
449447005198	thioester formation/cholesterol transfer; other site
449447005199	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447005200	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
449447005201	active site
449447005202	SAM binding site [chemical binding]; other site
449447005203	homodimer interface [polypeptide binding]; other site
449447005204	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
449447005205	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
449447005206	putative rRNA binding site [nucleotide binding]; other site
449447005207	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
449447005208	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
449447005209	RNA polymerase factor sigma-70; Validated; Region: PRK08295
449447005210	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
449447005211	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
449447005212	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
449447005213	putative active site [active]
449447005214	metal binding site [ion binding]; metal-binding site
449447005215	Protein of function (DUF2518); Region: DUF2518; pfam10726
449447005216	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
449447005217	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447005218	FeS/SAM binding site; other site
449447005219	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447005220	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
449447005221	Ligand Binding Site [chemical binding]; other site
449447005222	Predicted membrane protein [Function unknown]; Region: COG1971
449447005223	Domain of unknown function DUF; Region: DUF204; pfam02659
449447005224	Domain of unknown function DUF; Region: DUF204; pfam02659
449447005225	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
449447005226	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
449447005227	TM-ABC transporter signature motif; other site
449447005228	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005229	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447005230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
449447005231	Clp protease ATP binding subunit; Region: clpC; CHL00095
449447005232	Clp amino terminal domain; Region: Clp_N; pfam02861
449447005233	Clp amino terminal domain; Region: Clp_N; pfam02861
449447005234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005235	Walker A motif; other site
449447005236	ATP binding site [chemical binding]; other site
449447005237	Walker B motif; other site
449447005238	arginine finger; other site
449447005239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005240	Walker A motif; other site
449447005241	ATP binding site [chemical binding]; other site
449447005242	Walker B motif; other site
449447005243	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
449447005244	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
449447005245	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
449447005246	putative active site [active]
449447005247	catalytic triad [active]
449447005248	putative dimer interface [polypeptide binding]; other site
449447005249	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447005250	GAF domain; Region: GAF_2; pfam13185
449447005251	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005252	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
449447005253	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
449447005254	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
449447005255	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
449447005256	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
449447005257	catalytic site [active]
449447005258	putative active site [active]
449447005259	putative substrate binding site [chemical binding]; other site
449447005260	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
449447005261	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
449447005262	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447005263	anti sigma factor interaction site; other site
449447005264	regulatory phosphorylation site [posttranslational modification]; other site
449447005265	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
449447005266	Bacterial sugar transferase; Region: Bac_transf; pfam02397
449447005267	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
449447005268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
449447005269	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005270	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447005271	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447005272	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005273	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005274	active site
449447005275	ATP binding site [chemical binding]; other site
449447005276	substrate binding site [chemical binding]; other site
449447005277	activation loop (A-loop); other site
449447005278	GUN4-like; Region: GUN4; pfam05419
449447005279	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
449447005280	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
449447005281	active site
449447005282	metal binding site [ion binding]; metal-binding site
449447005283	DNA binding site [nucleotide binding]
449447005284	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
449447005285	PetN; Region: PetN; pfam03742
449447005286	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
449447005287	active site
449447005288	dimer interface [polypeptide binding]; other site
449447005289	metal binding site [ion binding]; metal-binding site
449447005290	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
449447005291	Predicted ATPase [General function prediction only]; Region: COG4637
449447005292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447005293	Walker A/P-loop; other site
449447005294	ATP binding site [chemical binding]; other site
449447005295	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
449447005296	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447005297	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447005298	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
449447005299	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
449447005300	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
449447005301	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
449447005302	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
449447005303	active site
449447005304	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
449447005305	nucleophilic elbow; other site
449447005306	catalytic triad; other site
449447005307	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
449447005308	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
449447005309	Jacalin-like lectin domain of griffithsin and related proteins; Region: griffithsin_like; cd09614
449447005310	sugar binding site [chemical binding]; other site
449447005311	Jacalin-like lectin domain of griffithsin and related proteins; Region: griffithsin_like; cd09614
449447005312	sugar binding site [chemical binding]; other site
449447005313	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
449447005314	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
449447005315	nucleophilic elbow; other site
449447005316	catalytic triad; other site
449447005317	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
449447005318	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
449447005319	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
449447005320	catalytic residue [active]
449447005321	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447005322	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447005323	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447005324	phosphopeptide binding site; other site
449447005325	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447005326	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
449447005327	C-terminal peptidase (prc); Region: prc; TIGR00225
449447005328	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447005329	protein binding site [polypeptide binding]; other site
449447005330	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447005331	Catalytic dyad [active]
449447005332	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
449447005333	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
449447005334	Cell division protein FtsQ; Region: FtsQ; pfam03799
449447005335	cell division protein FtsZ; Validated; Region: PRK09330
449447005336	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
449447005337	nucleotide binding site [chemical binding]; other site
449447005338	SulA interaction site; other site
449447005339	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
449447005340	dimer interface [polypeptide binding]; other site
449447005341	substrate binding site [chemical binding]; other site
449447005342	ATP binding site [chemical binding]; other site
449447005343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005344	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005345	Probable transposase; Region: OrfB_IS605; pfam01385
449447005346	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005347	Serine hydrolase; Region: Ser_hydrolase; cl17834
449447005348	Caspase domain; Region: Peptidase_C14; pfam00656
449447005349	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005350	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005351	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005352	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005353	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005354	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005356	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005357	Group XII secretory phospholipase A2 precursor (PLA2G12); Region: PLA2G12; pfam06951
449447005358	Uncharacterized conserved protein [Function unknown]; Region: COG0397
449447005359	hypothetical protein; Validated; Region: PRK00029
449447005360	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
449447005361	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
449447005362	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
449447005363	dimer interface [polypeptide binding]; other site
449447005364	tetramer interface [polypeptide binding]; other site
449447005365	PYR/PP interface [polypeptide binding]; other site
449447005366	TPP binding site [chemical binding]; other site
449447005367	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
449447005368	TPP-binding site; other site
449447005369	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
449447005370	MPN+ (JAMM) motif; other site
449447005371	Zinc-binding site [ion binding]; other site
449447005372	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
449447005373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
449447005374	conserved hypothetical protein; Region: TIGR03492
449447005375	Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484
449447005376	Haemolysin XhlA; Region: XhlA; pfam10779
449447005377	Haemolysin XhlA; Region: XhlA; pfam10779
449447005378	Haemagglutinin-neuraminidase; Region: HN; pfam00423
449447005379	Haemolysin XhlA; Region: XhlA; pfam10779
449447005380	Haemolysin XhlA; Region: XhlA; pfam10779
449447005381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005382	TPR motif; other site
449447005383	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005384	binding surface
449447005385	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005387	binding surface
449447005388	TPR motif; other site
449447005389	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005391	binding surface
449447005392	TPR motif; other site
449447005393	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005394	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005396	binding surface
449447005397	TPR motif; other site
449447005398	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005399	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447005400	Tetratricopeptide repeat; Region: TPR_1; pfam00515
449447005401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447005402	Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384
449447005403	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
449447005404	active site
449447005405	nucleotide binding site [chemical binding]; other site
449447005406	HIGH motif; other site
449447005407	KMSKS motif; other site
449447005408	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
449447005409	Ycf46; Provisional; Region: ycf46; CHL00195
449447005410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447005411	Walker A motif; other site
449447005412	ATP binding site [chemical binding]; other site
449447005413	Walker B motif; other site
449447005414	arginine finger; other site
449447005415	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
449447005416	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
449447005417	Walker A/P-loop; other site
449447005418	ATP binding site [chemical binding]; other site
449447005419	Q-loop/lid; other site
449447005420	ABC transporter signature motif; other site
449447005421	Walker B; other site
449447005422	D-loop; other site
449447005423	H-loop/switch region; other site
449447005424	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
449447005425	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447005426	substrate binding pocket [chemical binding]; other site
449447005427	membrane-bound complex binding site; other site
449447005428	hinge residues; other site
449447005429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447005430	dimer interface [polypeptide binding]; other site
449447005431	conserved gate region; other site
449447005432	putative PBP binding loops; other site
449447005433	ABC-ATPase subunit interface; other site
449447005434	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005435	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005436	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447005437	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447005438	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447005439	catalytic residues [active]
449447005440	catalytic nucleophile [active]
449447005441	Probable transposase; Region: OrfB_IS605; pfam01385
449447005442	Probable transposase; Region: OrfB_IS605; pfam01385
449447005443	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005444	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005445	PemK-like protein; Region: PemK; pfam02452
449447005446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005447	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005448	Probable transposase; Region: OrfB_IS605; pfam01385
449447005449	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005450	nickel-responsive transcriptional regulator NikR; Region: nikR; TIGR02793
449447005451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447005452	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447005453	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005454	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005455	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005456	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447005457	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
449447005458	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
449447005459	glutaminase active site [active]
449447005460	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
449447005461	dimer interface [polypeptide binding]; other site
449447005462	active site
449447005463	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
449447005464	dimer interface [polypeptide binding]; other site
449447005465	active site
449447005466	Probable transposase; Region: OrfB_IS605; pfam01385
449447005467	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005468	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005469	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
449447005470	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
449447005471	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447005472	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447005473	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447005474	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005475	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005476	glucokinase; Provisional; Region: glk; PRK00292
449447005477	glucokinase, proteobacterial type; Region: glk; TIGR00749
449447005478	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
449447005479	putative hexamer interface [polypeptide binding]; other site
449447005480	putative hexagonal pore; other site
449447005481	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
449447005482	putative hexamer interface [polypeptide binding]; other site
449447005483	putative hexagonal pore; other site
449447005484	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
449447005485	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447005486	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447005487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447005488	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447005489	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005490	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005491	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005492	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005493	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447005495	active site
449447005496	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
449447005497	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
449447005498	putative homodimer interface [polypeptide binding]; other site
449447005499	putative homotetramer interface [polypeptide binding]; other site
449447005500	putative metal binding site [ion binding]; other site
449447005501	putative homodimer-homodimer interface [polypeptide binding]; other site
449447005502	putative allosteric switch controlling residues; other site
449447005503	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
449447005504	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
449447005505	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447005506	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
449447005507	PHP domain; Region: PHP; pfam02811
449447005508	active site
449447005509	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005510	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005511	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005512	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005513	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005516	Probable transposase; Region: OrfB_IS605; pfam01385
449447005517	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005518	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447005519	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005520	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447005521	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447005522	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005523	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005524	active site
449447005525	ATP binding site [chemical binding]; other site
449447005526	substrate binding site [chemical binding]; other site
449447005527	activation loop (A-loop); other site
449447005528	TPR repeat; Region: TPR_11; pfam13414
449447005529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005530	binding surface
449447005531	TPR motif; other site
449447005532	TPR repeat; Region: TPR_11; pfam13414
449447005533	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005534	binding surface
449447005535	TPR motif; other site
449447005536	TPR repeat; Region: TPR_11; pfam13414
449447005537	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
449447005538	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447005539	proposed catalytic triad [active]
449447005540	active site nucleophile [active]
449447005541	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
449447005542	ATP-grasp domain; Region: ATP-grasp_4; cl17255
449447005543	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447005544	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447005545	DNA methylase; Region: N6_N4_Mtase; cl17433
449447005546	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447005547	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005548	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005549	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005550	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
449447005551	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
449447005552	substrate binding site [chemical binding]; other site
449447005553	ATP binding site [chemical binding]; other site
449447005554	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
449447005555	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
449447005556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005557	NAD(P) binding site [chemical binding]; other site
449447005558	active site
449447005559	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
449447005560	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
449447005561	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
449447005562	Short C-terminal domain; Region: SHOCT; pfam09851
449447005563	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
449447005564	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
449447005565	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005566	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005567	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005568	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447005569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005570	Probable transposase; Region: OrfB_IS605; pfam01385
449447005571	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005572	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447005573	Protein export membrane protein; Region: SecD_SecF; cl14618
449447005574	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447005575	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447005576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
449447005577	PAS domain; Region: PAS_9; pfam13426
449447005578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
449447005579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
449447005580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
449447005581	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
449447005582	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447005583	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
449447005584	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005585	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447005586	active site
449447005587	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005588	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447005589	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447005590	KR domain; Region: KR; pfam08659
449447005591	putative NADP binding site [chemical binding]; other site
449447005592	active site
449447005593	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447005594	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447005595	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005596	active site
449447005597	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447005598	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447005599	Condensation domain; Region: Condensation; pfam00668
449447005600	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447005601	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447005602	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
449447005603	acyl-activating enzyme (AAE) consensus motif; other site
449447005604	AMP binding site [chemical binding]; other site
449447005605	Condensation domain; Region: Condensation; pfam00668
449447005606	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447005607	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447005608	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
449447005609	active site
449447005610	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005611	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447005612	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447005613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447005614	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
449447005615	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447005616	putative NADP binding site [chemical binding]; other site
449447005617	active site
449447005618	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
449447005619	active site
449447005620	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447005621	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447005622	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
449447005623	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
449447005624	active site 1 [active]
449447005625	dimer interface [polypeptide binding]; other site
449447005626	active site 2 [active]
449447005627	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
449447005628	active site 1 [active]
449447005629	dimer interface [polypeptide binding]; other site
449447005630	active site 2 [active]
449447005631	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
449447005632	FMN binding site [chemical binding]; other site
449447005633	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
449447005634	substrate binding site [chemical binding]; other site
449447005635	putative catalytic residue [active]
449447005636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447005637	Major Facilitator Superfamily; Region: MFS_1; pfam07690
449447005638	putative substrate translocation pore; other site
449447005639	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447005640	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
449447005641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447005642	Nanovirus component 8 (C8) protein; Region: Nanovirus_C8; pfam05629
449447005643	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447005644	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
449447005645	Walker A/P-loop; other site
449447005646	ATP binding site [chemical binding]; other site
449447005647	Q-loop/lid; other site
449447005648	ABC transporter signature motif; other site
449447005649	Walker B; other site
449447005650	D-loop; other site
449447005651	H-loop/switch region; other site
449447005652	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
449447005653	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
449447005654	HEAT repeats; Region: HEAT_2; pfam13646
449447005655	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447005656	HEAT repeats; Region: HEAT_2; pfam13646
449447005657	HEAT repeats; Region: HEAT_2; pfam13646
449447005658	pyruvate kinase; Provisional; Region: PRK06354
449447005659	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
449447005660	domain interfaces; other site
449447005661	active site
449447005662	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
449447005663	S-layer homology domain; Region: SLH; pfam00395
449447005664	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447005665	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
449447005666	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447005667	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447005668	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
449447005669	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447005670	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
449447005671	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
449447005672	active site
449447005673	nucleophile elbow; other site
449447005674	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
449447005675	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
449447005676	ligand binding site; other site
449447005677	oligomer interface; other site
449447005678	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
449447005679	dimer interface [polypeptide binding]; other site
449447005680	N-terminal domain interface [polypeptide binding]; other site
449447005681	sulfate 1 binding site; other site
449447005682	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
449447005683	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
449447005684	FMN binding site [chemical binding]; other site
449447005685	active site
449447005686	catalytic residues [active]
449447005687	substrate binding site [chemical binding]; other site
449447005688	Domain of unknown function (DUF362); Region: DUF362; pfam04015
449447005689	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
449447005690	iron-sulfur cluster [ion binding]; other site
449447005691	[2Fe-2S] cluster binding site [ion binding]; other site
449447005692	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
449447005693	Response regulator receiver domain; Region: Response_reg; pfam00072
449447005694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005695	active site
449447005696	phosphorylation site [posttranslational modification]
449447005697	intermolecular recognition site; other site
449447005698	dimerization interface [polypeptide binding]; other site
449447005699	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
449447005700	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
449447005701	UGMP family protein; Validated; Region: PRK09604
449447005702	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
449447005703	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
449447005704	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
449447005705	RNA binding site [nucleotide binding]; other site
449447005706	active site
449447005707	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
449447005708	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
449447005709	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447005710	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447005711	homodimer interface [polypeptide binding]; other site
449447005712	catalytic residue [active]
449447005713	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
449447005714	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
449447005715	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
449447005716	hydrolase, alpha/beta fold family protein; Region: PLN02824
449447005717	PGAP1-like protein; Region: PGAP1; pfam07819
449447005718	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447005719	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447005720	DNA-binding interface [nucleotide binding]; DNA binding site
449447005721	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005723	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
449447005724	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
449447005725	putative anticodon binding site; other site
449447005726	dimer interface [polypeptide binding]; other site
449447005727	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
449447005728	motif 1; other site
449447005729	active site
449447005730	motif 2; other site
449447005731	motif 3; other site
449447005732	KTSC domain; Region: KTSC; pfam13619
449447005733	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447005734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005735	active site
449447005736	phosphorylation site [posttranslational modification]
449447005737	intermolecular recognition site; other site
449447005738	dimerization interface [polypeptide binding]; other site
449447005739	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
449447005740	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447005741	metal binding site 2 [ion binding]; metal-binding site
449447005742	putative DNA binding helix; other site
449447005743	metal binding site 1 [ion binding]; metal-binding site
449447005744	dimer interface [polypeptide binding]; other site
449447005745	structural Zn2+ binding site [ion binding]; other site
449447005746	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447005747	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447005748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447005749	active site
449447005750	phosphorylation site [posttranslational modification]
449447005751	intermolecular recognition site; other site
449447005752	dimerization interface [polypeptide binding]; other site
449447005753	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447005754	DNA binding site [nucleotide binding]
449447005755	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
449447005756	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
449447005757	Walker A/P-loop; other site
449447005758	ATP binding site [chemical binding]; other site
449447005759	Q-loop/lid; other site
449447005760	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
449447005761	ABC transporter signature motif; other site
449447005762	Walker B; other site
449447005763	D-loop; other site
449447005764	H-loop/switch region; other site
449447005765	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005766	putative active site [active]
449447005767	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005768	putative active site [active]
449447005769	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
449447005770	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
449447005771	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
449447005772	active site
449447005773	HIGH motif; other site
449447005774	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
449447005775	KMSKS motif; other site
449447005776	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
449447005777	tRNA binding surface [nucleotide binding]; other site
449447005778	anticodon binding site; other site
449447005779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447005780	ABC-ATPase subunit interface; other site
449447005781	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
449447005782	Uncharacterized conserved protein [Function unknown]; Region: COG5607
449447005783	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
449447005784	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
449447005785	active site
449447005786	dimer interface [polypeptide binding]; other site
449447005787	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447005788	active site
449447005789	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447005790	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
449447005791	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
449447005792	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
449447005793	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
449447005794	dimerization interface [polypeptide binding]; other site
449447005795	active site
449447005796	metal binding site [ion binding]; metal-binding site
449447005797	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447005798	anti sigma factor interaction site; other site
449447005799	regulatory phosphorylation site [posttranslational modification]; other site
449447005800	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
449447005801	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
449447005802	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
449447005803	catalytic site [active]
449447005804	subunit interface [polypeptide binding]; other site
449447005805	Transposase; Region: HTH_Tnp_1; cl17663
449447005806	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447005807	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005808	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005809	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005810	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005811	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447005812	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
449447005813	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
449447005814	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447005815	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447005816	active site
449447005817	ATP binding site [chemical binding]; other site
449447005818	substrate binding site [chemical binding]; other site
449447005819	activation loop (A-loop); other site
449447005820	RDD family; Region: RDD; pfam06271
449447005821	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
449447005822	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
449447005823	active site residue [active]
449447005824	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
449447005825	Recombination protein O N terminal; Region: RecO_N; pfam11967
449447005826	Recombination protein O C terminal; Region: RecO_C; pfam02565
449447005827	H+ Antiporter protein; Region: 2A0121; TIGR00900
449447005828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447005829	putative substrate translocation pore; other site
449447005830	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005831	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447005832	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447005833	Calx-beta domain; Region: Calx-beta; cl02522
449447005834	Calx-beta domain; Region: Calx-beta; cl02522
449447005835	Calx-beta domain; Region: Calx-beta; cl02522
449447005836	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005837	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005838	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005839	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005840	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005842	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005843	Caspase domain; Region: Peptidase_C14; pfam00656
449447005844	Serine hydrolase; Region: Ser_hydrolase; cl17834
449447005845	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447005846	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
449447005847	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005848	binding surface
449447005849	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447005850	TPR motif; other site
449447005851	TPR repeat; Region: TPR_11; pfam13414
449447005852	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447005853	binding surface
449447005854	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447005855	TPR motif; other site
449447005856	TPR repeat; Region: TPR_11; pfam13414
449447005857	Ferritin-like domain; Region: Ferritin; pfam00210
449447005858	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447005859	dinuclear metal binding motif [ion binding]; other site
449447005860	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447005861	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
449447005862	putative ligand binding site [chemical binding]; other site
449447005863	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447005864	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447005865	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447005866	cofactor binding site; other site
449447005867	DNA binding site [nucleotide binding]
449447005868	substrate interaction site [chemical binding]; other site
449447005869	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005870	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005872	Paired Box domain; Region: PAX; cd00131
449447005873	DNA binding site [nucleotide binding]
449447005874	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005875	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005876	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447005877	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447005878	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447005879	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005880	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005881	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005882	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005883	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005884	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005885	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005887	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447005888	putative active site [active]
449447005889	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
449447005890	substrate binding site [chemical binding]; other site
449447005891	putative active site [active]
449447005892	redox center [active]
449447005893	Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961
449447005894	catalytic residues [active]
449447005895	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
449447005896	phosphate binding site [ion binding]; other site
449447005897	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
449447005898	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
449447005899	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447005900	FeS/SAM binding site; other site
449447005901	TRAM domain; Region: TRAM; cl01282
449447005902	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
449447005903	DEAD-like helicases superfamily; Region: DEXDc; smart00487
449447005904	ATP binding site [chemical binding]; other site
449447005905	Mg++ binding site [ion binding]; other site
449447005906	motif III; other site
449447005907	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447005908	nucleotide binding region [chemical binding]; other site
449447005909	ATP-binding site [chemical binding]; other site
449447005910	Uncharacterized conserved protein [Function unknown]; Region: COG1479
449447005911	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447005912	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
449447005913	Predicted helicase [General function prediction only]; Region: COG4889
449447005914	Family description; Region: VCBS; pfam13517
449447005915	Family description; Region: VCBS; pfam13517
449447005916	Family description; Region: VCBS; pfam13517
449447005917	Family description; Region: VCBS; pfam13517
449447005918	Family description; Region: VCBS; pfam13517
449447005919	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
449447005920	iron-sulfur cluster [ion binding]; other site
449447005921	[2Fe-2S] cluster binding site [ion binding]; other site
449447005922	Family description; Region: VCBS; pfam13517
449447005923	Family description; Region: VCBS; pfam13517
449447005924	Family description; Region: VCBS; pfam13517
449447005925	Family description; Region: VCBS; pfam13517
449447005926	Family description; Region: VCBS; pfam13517
449447005927	Family description; Region: VCBS; pfam13517
449447005928	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447005929	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
449447005930	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
449447005931	active site
449447005932	dimer interface [polypeptide binding]; other site
449447005933	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
449447005934	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
449447005935	active site
449447005936	FMN binding site [chemical binding]; other site
449447005937	substrate binding site [chemical binding]; other site
449447005938	3Fe-4S cluster binding site [ion binding]; other site
449447005939	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
449447005940	domain interface; other site
449447005941	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
449447005942	CoA binding domain; Region: CoA_binding; smart00881
449447005943	CoA-ligase; Region: Ligase_CoA; pfam00549
449447005944	YGGT family; Region: YGGT; pfam02325
449447005945	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
449447005946	proposed catalytic triad [active]
449447005947	active site nucleophile [active]
449447005948	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447005949	CsbD-like; Region: CsbD; pfam05532
449447005950	CsbD-like; Region: CsbD; pfam05532
449447005951	CsbD-like; Region: CsbD; cl17424
449447005952	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005953	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005954	Probable transposase; Region: OrfB_IS605; pfam01385
449447005955	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005956	BON domain; Region: BON; pfam04972
449447005957	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447005958	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447005959	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447005960	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447005961	Homeodomain-like domain; Region: HTH_23; pfam13384
449447005962	Winged helix-turn helix; Region: HTH_29; pfam13551
449447005963	Homeodomain-like domain; Region: HTH_32; pfam13565
449447005964	Winged helix-turn helix; Region: HTH_33; pfam13592
449447005965	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447005966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447005967	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447005968	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
449447005969	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447005970	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447005971	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447005972	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005973	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447005974	Probable transposase; Region: OrfB_IS605; pfam01385
449447005975	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447005976	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
449447005977	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
449447005978	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
449447005979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
449447005980	Walker A motif; other site
449447005981	ATP binding site [chemical binding]; other site
449447005982	Walker B motif; other site
449447005983	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447005984	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
449447005985	B12 binding site [chemical binding]; other site
449447005986	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447005987	FeS/SAM binding site; other site
449447005988	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447005989	RRXRR protein; Region: RRXRR; pfam14239
449447005990	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447005991	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447005992	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447005993	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
449447005994	DXD motif; other site
449447005995	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447005996	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
449447005997	MgtC family; Region: MgtC; pfam02308
449447005998	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447005999	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006000	Probable transposase; Region: OrfB_IS605; pfam01385
449447006001	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006002	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006003	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006004	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006005	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006006	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
449447006007	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821
449447006008	putative heme binding site [chemical binding]; other site
449447006009	putative substrate binding site [chemical binding]; other site
449447006010	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
449447006011	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006012	biotin synthase; Provisional; Region: PRK15108
449447006013	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
449447006014	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
449447006015	active site
449447006016	dimer interface [polypeptide binding]; other site
449447006017	non-prolyl cis peptide bond; other site
449447006018	insertion regions; other site
449447006019	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447006020	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447006021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
449447006022	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
449447006023	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
449447006024	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
449447006025	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
449447006026	active site
449447006027	dimer interface [polypeptide binding]; other site
449447006028	non-prolyl cis peptide bond; other site
449447006029	insertion regions; other site
449447006030	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
449447006031	Na binding site [ion binding]; other site
449447006032	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
449447006033	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
449447006034	Flavin binding site [chemical binding]; other site
449447006035	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
449447006036	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
449447006037	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
449447006038	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
449447006039	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
449447006040	dimerization interface [polypeptide binding]; other site
449447006041	active site
449447006042	S-layer homology domain; Region: SLH; pfam00395
449447006043	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
449447006044	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
449447006045	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
449447006046	Flavin binding site [chemical binding]; other site
449447006047	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447006048	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
449447006049	Double zinc ribbon; Region: DZR; pfam12773
449447006050	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
449447006051	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
449447006052	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
449447006053	NADP binding site [chemical binding]; other site
449447006054	active site
449447006055	putative substrate binding site [chemical binding]; other site
449447006056	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
449447006057	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
449447006058	NADP-binding site; other site
449447006059	homotetramer interface [polypeptide binding]; other site
449447006060	substrate binding site [chemical binding]; other site
449447006061	homodimer interface [polypeptide binding]; other site
449447006062	active site
449447006063	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
449447006064	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447006065	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447006066	P-loop; other site
449447006067	Magnesium ion binding site [ion binding]; other site
449447006068	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447006069	Magnesium ion binding site [ion binding]; other site
449447006070	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447006071	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447006072	active site
449447006073	metal binding site [ion binding]; metal-binding site
449447006074	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
449447006075	putative substrate binding pocket [chemical binding]; other site
449447006076	catalytic triad [active]
449447006077	AB domain interface; other site
449447006078	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
449447006079	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
449447006080	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
449447006081	Probable transposase; Region: OrfB_IS605; pfam01385
449447006082	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006083	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447006084	Probable transposase; Region: OrfB_IS605; pfam01385
449447006085	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447006086	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447006087	catalytic residues [active]
449447006088	catalytic nucleophile [active]
449447006089	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
449447006090	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
449447006091	tRNA; other site
449447006092	putative tRNA binding site [nucleotide binding]; other site
449447006093	putative NADP binding site [chemical binding]; other site
449447006094	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
449447006095	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
449447006096	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
449447006097	putative active site [active]
449447006098	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447006099	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447006100	active site
449447006101	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
449447006102	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
449447006103	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
449447006104	trimer interface [polypeptide binding]; other site
449447006105	putative metal binding site [ion binding]; other site
449447006106	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
449447006107	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
449447006108	FAD binding domain; Region: FAD_binding_4; pfam01565
449447006109	adenylosuccinate lyase; Provisional; Region: PRK07380
449447006110	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
449447006111	tetramer interface [polypeptide binding]; other site
449447006112	active site
449447006113	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
449447006114	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006115	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006116	Homeodomain-like domain; Region: HTH_32; pfam13565
449447006117	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006119	DNA methylase; Region: N6_N4_Mtase; cl17433
449447006120	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447006121	non-specific DNA binding site [nucleotide binding]; other site
449447006122	salt bridge; other site
449447006123	sequence-specific DNA binding site [nucleotide binding]; other site
449447006124	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447006125	Predicted ATPase [General function prediction only]; Region: COG4637
449447006126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006128	Walker A/P-loop; other site
449447006129	Walker A/P-loop; other site
449447006130	ATP binding site [chemical binding]; other site
449447006131	ATP binding site [chemical binding]; other site
449447006132	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
449447006133	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
449447006134	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
449447006135	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
449447006136	Ion channel; Region: Ion_trans_2; pfam07885
449447006137	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447006138	TrkA-N domain; Region: TrkA_N; pfam02254
449447006139	TrkA-C domain; Region: TrkA_C; pfam02080
449447006140	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447006141	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447006142	cobalamin synthase; Reviewed; Region: cobS; PRK00235
449447006143	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447006144	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006145	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006146	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006147	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006148	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006149	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006150	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006151	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006152	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447006154	Uncharacterized conserved protein [Function unknown]; Region: COG2442
449447006155	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006156	threonine dehydratase; Reviewed; Region: PRK09224
449447006157	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
449447006158	tetramer interface [polypeptide binding]; other site
449447006159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447006160	catalytic residue [active]
449447006161	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
449447006162	putative Ile/Val binding site [chemical binding]; other site
449447006163	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
449447006164	putative Ile/Val binding site [chemical binding]; other site
449447006165	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
449447006166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006167	S-adenosylmethionine binding site [chemical binding]; other site
449447006168	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
449447006169	aspartate aminotransferase; Provisional; Region: PRK05957
449447006170	aspartate aminotransferase; Provisional; Region: PRK05957
449447006171	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447006172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447006173	homodimer interface [polypeptide binding]; other site
449447006174	catalytic residue [active]
449447006175	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447006176	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447006177	structural tetrad; other site
449447006178	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447006179	HSP70 interaction site [polypeptide binding]; other site
449447006180	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447006181	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447006182	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447006183	protein binding site [polypeptide binding]; other site
449447006184	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447006185	ribosome recycling factor; Reviewed; Region: frr; PRK00083
449447006186	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
449447006187	hinge region; other site
449447006188	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
449447006189	putative nucleotide binding site [chemical binding]; other site
449447006190	uridine monophosphate binding site [chemical binding]; other site
449447006191	homohexameric interface [polypeptide binding]; other site
449447006192	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
449447006193	Dehydroquinase class II; Region: DHquinase_II; pfam01220
449447006194	trimer interface [polypeptide binding]; other site
449447006195	active site
449447006196	dimer interface [polypeptide binding]; other site
449447006197	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
449447006198	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
449447006199	Pheophorbide a oxygenase; Region: PaO; pfam08417
449447006200	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447006201	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447006202	active site
449447006203	ATP binding site [chemical binding]; other site
449447006204	substrate binding site [chemical binding]; other site
449447006205	activation loop (A-loop); other site
449447006206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006207	binding surface
449447006208	TPR motif; other site
449447006209	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447006210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006211	binding surface
449447006212	TPR motif; other site
449447006213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006214	binding surface
449447006215	TPR motif; other site
449447006216	TPR repeat; Region: TPR_11; pfam13414
449447006217	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447006218	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447006219	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447006220	protein binding site [polypeptide binding]; other site
449447006221	WYL domain; Region: WYL; pfam13280
449447006222	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
449447006223	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
449447006224	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447006225	active site
449447006226	NTP binding site [chemical binding]; other site
449447006227	metal binding triad [ion binding]; metal-binding site
449447006228	antibiotic binding site [chemical binding]; other site
449447006229	Protein of unknown function DUF86; Region: DUF86; pfam01934
449447006230	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447006231	active site
449447006232	NTP binding site [chemical binding]; other site
449447006233	metal binding triad [ion binding]; metal-binding site
449447006234	antibiotic binding site [chemical binding]; other site
449447006235	Protein of unknown function DUF86; Region: DUF86; pfam01934
449447006236	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
449447006237	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
449447006238	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
449447006239	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
449447006240	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
449447006241	WYL domain; Region: WYL; pfam13280
449447006242	ribonuclease Y; Region: RNase_Y; TIGR03319
449447006243	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
449447006244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
449447006245	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
449447006246	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006247	putative active site [active]
449447006248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006249	putative active site [active]
449447006250	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
449447006251	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
449447006252	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
449447006253	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
449447006254	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447006255	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447006256	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006257	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
449447006258	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
449447006259	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
449447006260	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
449447006261	nudix motif; other site
449447006262	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
449447006263	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
449447006264	FtsX-like permease family; Region: FtsX; pfam02687
449447006265	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447006266	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
449447006267	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447006268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006269	TPR motif; other site
449447006270	binding surface
449447006271	TPR repeat; Region: TPR_11; pfam13414
449447006272	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006273	binding surface
449447006274	TPR motif; other site
449447006275	TPR repeat; Region: TPR_11; pfam13414
449447006276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006277	TPR repeat; Region: TPR_11; pfam13414
449447006278	binding surface
449447006279	TPR motif; other site
449447006280	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006281	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006282	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447006283	oligomeric interface; other site
449447006284	putative active site [active]
449447006285	homodimer interface [polypeptide binding]; other site
449447006286	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
449447006287	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
449447006288	active site
449447006289	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
449447006290	S-layer homology domain; Region: SLH; pfam00395
449447006291	S-layer homology domain; Region: SLH; pfam00395
449447006292	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
449447006293	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447006294	metal-binding site [ion binding]
449447006295	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447006296	Soluble P-type ATPase [General function prediction only]; Region: COG4087
449447006297	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
449447006298	substrate binding site [chemical binding]; other site
449447006299	active site
449447006300	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
449447006301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006302	NAD(P) binding site [chemical binding]; other site
449447006303	active site
449447006304	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447006305	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447006306	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
449447006307	Walker A/P-loop; other site
449447006308	ATP binding site [chemical binding]; other site
449447006309	Q-loop/lid; other site
449447006310	ABC transporter signature motif; other site
449447006311	Walker B; other site
449447006312	D-loop; other site
449447006313	H-loop/switch region; other site
449447006314	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
449447006315	ligand-binding site [chemical binding]; other site
449447006316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447006317	binding surface
449447006318	TPR motif; other site
449447006319	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
449447006320	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
449447006321	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447006322	catalytic residue [active]
449447006323	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
449447006324	dephospho-CoA kinase; Region: TIGR00152
449447006325	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
449447006326	CoA-binding site [chemical binding]; other site
449447006327	ATP-binding [chemical binding]; other site
449447006328	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
449447006329	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
449447006330	ATP binding site [chemical binding]; other site
449447006331	active site
449447006332	substrate binding site [chemical binding]; other site
449447006333	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006334	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006335	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006336	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006337	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
449447006338	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
449447006339	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
449447006340	active site
449447006341	dimer interface [polypeptide binding]; other site
449447006342	motif 1; other site
449447006343	motif 2; other site
449447006344	motif 3; other site
449447006345	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
449447006346	anticodon binding site; other site
449447006347	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
449447006348	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
449447006349	metal binding site [ion binding]; metal-binding site
449447006350	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447006351	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
449447006352	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
449447006353	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
449447006354	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
449447006355	Zn binding site [ion binding]; other site
449447006356	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
449447006357	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447006358	Predicted ATPase [General function prediction only]; Region: COG4637
449447006359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006361	Walker A/P-loop; other site
449447006362	Walker A/P-loop; other site
449447006363	ATP binding site [chemical binding]; other site
449447006364	ATP binding site [chemical binding]; other site
449447006365	Immunoglobulin domain; Region: Ig; cl11960
449447006366	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
449447006367	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
449447006368	Walker A/P-loop; other site
449447006369	ATP binding site [chemical binding]; other site
449447006370	Q-loop/lid; other site
449447006371	ABC transporter signature motif; other site
449447006372	Walker B; other site
449447006373	D-loop; other site
449447006374	H-loop/switch region; other site
449447006375	TOBE-like domain; Region: TOBE_3; pfam12857
449447006376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006377	dimer interface [polypeptide binding]; other site
449447006378	conserved gate region; other site
449447006379	putative PBP binding loops; other site
449447006380	ABC-ATPase subunit interface; other site
449447006381	sulfate transport protein; Provisional; Region: cysT; CHL00187
449447006382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006383	dimer interface [polypeptide binding]; other site
449447006384	conserved gate region; other site
449447006385	putative PBP binding loops; other site
449447006386	ABC-ATPase subunit interface; other site
449447006387	NIL domain; Region: NIL; pfam09383
449447006388	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
449447006389	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447006390	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447006391	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
449447006392	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
449447006393	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
449447006394	dimerization interface [polypeptide binding]; other site
449447006395	active site
449447006396	metal binding site [ion binding]; metal-binding site
449447006397	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
449447006398	dsRNA binding site [nucleotide binding]; other site
449447006399	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
449447006400	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
449447006401	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
449447006402	active site
449447006403	dimer interface [polypeptide binding]; other site
449447006404	motif 1; other site
449447006405	motif 2; other site
449447006406	motif 3; other site
449447006407	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
449447006408	anticodon binding site; other site
449447006409	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
449447006410	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447006411	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
449447006412	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447006413	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006414	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447006415	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
449447006416	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447006417	active site
449447006418	metal binding site [ion binding]; metal-binding site
449447006419	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
449447006420	metal binding site [ion binding]; metal-binding site
449447006421	tocopherol O-methyltransferase; Region: PLN02244
449447006422	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006423	S-adenosylmethionine binding site [chemical binding]; other site
449447006424	FeoC like transcriptional regulator; Region: FeoC; pfam09012
449447006425	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
449447006426	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
449447006427	G1 box; other site
449447006428	GTP/Mg2+ binding site [chemical binding]; other site
449447006429	Switch I region; other site
449447006430	G2 box; other site
449447006431	G3 box; other site
449447006432	Switch II region; other site
449447006433	G4 box; other site
449447006434	G5 box; other site
449447006435	Nucleoside recognition; Region: Gate; pfam07670
449447006436	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
449447006437	FeoA domain; Region: FeoA; pfam04023
449447006438	FeoA domain; Region: FeoA; pfam04023
449447006439	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447006440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447006441	dimer interface [polypeptide binding]; other site
449447006442	phosphorylation site [posttranslational modification]
449447006443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447006444	ATP binding site [chemical binding]; other site
449447006445	Mg2+ binding site [ion binding]; other site
449447006446	G-X-G motif; other site
449447006447	Response regulator receiver domain; Region: Response_reg; pfam00072
449447006448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447006449	active site
449447006450	phosphorylation site [posttranslational modification]
449447006451	intermolecular recognition site; other site
449447006452	dimerization interface [polypeptide binding]; other site
449447006453	KaiA domain; Region: KaiA; pfam07688
449447006454	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447006455	tetramer interface [polypeptide binding]; other site
449447006456	dimer interface [polypeptide binding]; other site
449447006457	circadian clock protein KaiC; Reviewed; Region: PRK09302
449447006458	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
449447006459	Walker A motif; other site
449447006460	ATP binding site [chemical binding]; other site
449447006461	Walker B motif; other site
449447006462	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447006463	ATP binding site [chemical binding]; other site
449447006464	Walker B motif; other site
449447006465	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
449447006466	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447006467	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
449447006468	inhibitor-cofactor binding pocket; inhibition site
449447006469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447006470	catalytic residue [active]
449447006471	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
449447006472	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
449447006473	AAA domain; Region: AAA_23; pfam13476
449447006474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006475	Walker A/P-loop; other site
449447006476	ATP binding site [chemical binding]; other site
449447006477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006478	ABC transporter signature motif; other site
449447006479	Walker B; other site
449447006480	D-loop; other site
449447006481	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
449447006482	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
449447006483	arginine-tRNA ligase; Region: PLN02286
449447006484	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
449447006485	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
449447006486	active site
449447006487	HIGH motif; other site
449447006488	KMSK motif region; other site
449447006489	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
449447006490	tRNA binding surface [nucleotide binding]; other site
449447006491	anticodon binding site; other site
449447006492	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447006493	YcfA-like protein; Region: YcfA; pfam07927
449447006494	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
449447006495	homotrimer interaction site [polypeptide binding]; other site
449447006496	zinc binding site [ion binding]; other site
449447006497	CDP-binding sites; other site
449447006498	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447006499	Predicted ATPase [General function prediction only]; Region: COG4637
449447006500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447006502	Walker A/P-loop; other site
449447006503	Walker A/P-loop; other site
449447006504	ATP binding site [chemical binding]; other site
449447006505	ATP binding site [chemical binding]; other site
449447006506	Immunoglobulin domain; Region: Ig; cl11960
449447006507	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
449447006508	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447006509	ATP binding site [chemical binding]; other site
449447006510	putative Mg++ binding site [ion binding]; other site
449447006511	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
449447006512	Predicted helicase [General function prediction only]; Region: COG4889
449447006513	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
449447006514	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
449447006515	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
449447006516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006517	conserved gate region; other site
449447006518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447006519	putative PBP binding loops; other site
449447006520	dimer interface [polypeptide binding]; other site
449447006521	ABC-ATPase subunit interface; other site
449447006522	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
449447006523	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
449447006524	G1 box; other site
449447006525	GTP/Mg2+ binding site [chemical binding]; other site
449447006526	G2 box; other site
449447006527	Switch I region; other site
449447006528	G3 box; other site
449447006529	Switch II region; other site
449447006530	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
449447006531	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
449447006532	active site
449447006533	catalytic motif [active]
449447006534	Zn binding site [ion binding]; other site
449447006535	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
449447006536	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
449447006537	Divergent AAA domain; Region: AAA_4; pfam04326
449447006538	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
449447006539	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
449447006540	Tic20-like protein; Region: Tic20; pfam09685
449447006541	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
449447006542	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
449447006543	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
449447006544	dimer interface [polypeptide binding]; other site
449447006545	motif 1; other site
449447006546	active site
449447006547	motif 2; other site
449447006548	motif 3; other site
449447006549	DNA methylase; Region: N6_N4_Mtase; cl17433
449447006550	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
449447006551	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
449447006552	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
449447006553	DHH family; Region: DHH; pfam01368
449447006554	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
449447006555	FOG: CBS domain [General function prediction only]; Region: COG0517
449447006556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
449447006557	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
449447006558	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
449447006559	active site
449447006560	NTP binding site [chemical binding]; other site
449447006561	metal binding triad [ion binding]; metal-binding site
449447006562	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
449447006563	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
449447006564	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
449447006565	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
449447006566	homopentamer interface [polypeptide binding]; other site
449447006567	active site
449447006568	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006569	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006570	Probable transposase; Region: OrfB_IS605; pfam01385
449447006571	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006572	V-type ATP synthase subunit I; Validated; Region: PRK05771
449447006573	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
449447006574	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
449447006575	putative catalytic cysteine [active]
449447006576	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
449447006577	Permease; Region: Permease; cl00510
449447006578	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447006579	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447006580	DNA-binding interface [nucleotide binding]; DNA binding site
449447006581	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006583	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
449447006584	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
449447006585	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447006586	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
449447006587	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
449447006588	active site
449447006589	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
449447006590	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
449447006591	phosphoglyceromutase; Provisional; Region: PRK05434
449447006592	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
449447006593	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
449447006594	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
449447006595	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
449447006596	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
449447006597	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447006598	RNA binding surface [nucleotide binding]; other site
449447006599	Bifunctional nuclease; Region: DNase-RNase; pfam02577
449447006600	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
449447006601	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447006602	active site
449447006603	catalytic tetrad [active]
449447006604	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
449447006605	intersubunit interface [polypeptide binding]; other site
449447006606	active site
449447006607	zinc binding site [ion binding]; other site
449447006608	Na+ binding site [ion binding]; other site
449447006609	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
449447006610	C-terminal peptidase (prc); Region: prc; TIGR00225
449447006611	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447006612	protein binding site [polypeptide binding]; other site
449447006613	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447006614	Catalytic dyad [active]
449447006615	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447006616	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
449447006617	putative ligand binding site [chemical binding]; other site
449447006618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006619	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006620	Probable transposase; Region: OrfB_IS605; pfam01385
449447006621	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006622	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
449447006623	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447006624	putative active site [active]
449447006625	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
449447006626	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006627	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447006628	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447006629	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006630	hypothetical protein; Validated; Region: PRK07411
449447006631	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
449447006632	ATP binding site [chemical binding]; other site
449447006633	substrate interface [chemical binding]; other site
449447006634	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
449447006635	active site residue [active]
449447006636	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
449447006637	lipoyl attachment site [posttranslational modification]; other site
449447006638	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
449447006639	CoA binding domain; Region: CoA_binding_2; pfam13380
449447006640	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
449447006641	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
449447006642	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447006643	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
449447006644	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447006645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006646	NAD(P) binding site [chemical binding]; other site
449447006647	active site
449447006648	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006649	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
449447006650	putative ADP-binding pocket [chemical binding]; other site
449447006651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006652	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006653	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
449447006654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006655	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447006656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006657	S-adenosylmethionine binding site [chemical binding]; other site
449447006658	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
449447006659	metal-binding site
449447006660	Transposase domain (DUF772); Region: DUF772; pfam05598
449447006661	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447006662	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006663	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006664	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006665	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447006666	putative active site [active]
449447006667	Protein of unknown function (DUF433); Region: DUF433; cl01030
449447006668	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006670	Paired Box domain; Region: PAX; cd00131
449447006671	DNA binding site [nucleotide binding]
449447006672	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006673	Homeodomain-like domain; Region: HTH_32; pfam13565
449447006674	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006676	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447006677	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447006678	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447006679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447006680	NAD(P) binding site [chemical binding]; other site
449447006681	active site
449447006682	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447006683	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
449447006684	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
449447006685	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
449447006686	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
449447006687	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447006688	Chain length determinant protein; Region: Wzz; pfam02706
449447006689	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
449447006690	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447006691	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
449447006692	DNA photolyase; Region: DNA_photolyase; pfam00875
449447006693	quinolinate synthetase; Provisional; Region: PRK09375
449447006694	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
449447006695	photosystem II 47 kDa protein; Region: psbB; CHL00062
449447006696	photosystem II reaction center protein J; Provisional; Region: PRK02565
449447006697	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
449447006698	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
449447006699	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
449447006700	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
449447006701	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
449447006702	Rubredoxin [Energy production and conversion]; Region: COG1773
449447006703	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
449447006704	iron binding site [ion binding]; other site
449447006705	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
449447006706	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006707	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006708	Homeodomain-like domain; Region: HTH_32; pfam13565
449447006709	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006710	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006712	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
449447006713	YcaO-like family; Region: YcaO; pfam02624
449447006714	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
449447006715	Mannan-binding protein; Region: MVL; pfam12151
449447006716	Mannan-binding protein; Region: MVL; pfam12151
449447006717	YcaO-like family; Region: YcaO; pfam02624
449447006718	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447006719	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447006720	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447006721	putative active site [active]
449447006722	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
449447006723	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
449447006724	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447006725	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447006726	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447006727	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447006728	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447006729	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006730	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006731	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
449447006732	Protein of unknown function (DUF497); Region: DUF497; cl01108
449447006733	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
449447006734	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
449447006735	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447006736	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447006737	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447006738	active site
449447006739	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006740	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006741	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006742	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006743	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447006744	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447006745	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447006746	putative active site [active]
449447006747	putative NTP binding site [chemical binding]; other site
449447006748	putative nucleic acid binding site [nucleotide binding]; other site
449447006749	Amidohydrolase; Region: Amidohydro_2; pfam04909
449447006750	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447006751	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
449447006752	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447006753	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447006754	active site
449447006755	ATP binding site [chemical binding]; other site
449447006756	substrate binding site [chemical binding]; other site
449447006757	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447006758	substrate binding site [chemical binding]; other site
449447006759	activation loop (A-loop); other site
449447006760	activation loop (A-loop); other site
449447006761	AAA ATPase domain; Region: AAA_16; pfam13191
449447006762	Predicted ATPase [General function prediction only]; Region: COG3899
449447006763	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447006764	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447006765	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447006766	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447006767	putative metal binding site; other site
449447006768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006769	binding surface
449447006770	TPR repeat; Region: TPR_11; pfam13414
449447006771	TPR motif; other site
449447006772	TPR repeat; Region: TPR_11; pfam13414
449447006773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447006774	binding surface
449447006775	TPR motif; other site
449447006776	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
449447006777	dimerization interface [polypeptide binding]; other site
449447006778	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
449447006779	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
449447006780	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
449447006781	dimer interface [polypeptide binding]; other site
449447006782	putative CheW interface [polypeptide binding]; other site
449447006783	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
449447006784	Response regulator receiver domain; Region: Response_reg; pfam00072
449447006785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447006786	active site
449447006787	phosphorylation site [posttranslational modification]
449447006788	intermolecular recognition site; other site
449447006789	dimerization interface [polypeptide binding]; other site
449447006790	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006791	Probable transposase; Region: OrfB_IS605; pfam01385
449447006792	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006793	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447006794	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
449447006795	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
449447006796	substrate binding pocket [chemical binding]; other site
449447006797	substrate-Mg2+ binding site; other site
449447006798	aspartate-rich region 1; other site
449447006799	aspartate-rich region 2; other site
449447006800	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
449447006801	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
449447006802	interchain domain interface [polypeptide binding]; other site
449447006803	intrachain domain interface; other site
449447006804	Qi binding site; other site
449447006805	Qo binding site; other site
449447006806	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
449447006807	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
449447006808	Qi binding site; other site
449447006809	intrachain domain interface; other site
449447006810	interchain domain interface [polypeptide binding]; other site
449447006811	heme bH binding site [chemical binding]; other site
449447006812	heme bL binding site [chemical binding]; other site
449447006813	Qo binding site; other site
449447006814	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006815	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447006816	Probable transposase; Region: OrfB_IS605; pfam01385
449447006817	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006818	Uncharacterized conserved protein [Function unknown]; Region: COG2308
449447006819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
449447006820	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
449447006821	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447006822	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
449447006823	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447006824	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006825	Probable transposase; Region: OrfB_IS605; pfam01385
449447006826	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006827	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
449447006828	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006829	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006830	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006831	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006832	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
449447006833	Protein of unknown function (DUF456); Region: DUF456; pfam04306
449447006834	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
449447006835	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447006836	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447006837	cofactor binding site; other site
449447006838	DNA binding site [nucleotide binding]
449447006839	substrate interaction site [chemical binding]; other site
449447006840	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006841	Probable transposase; Region: OrfB_IS605; pfam01385
449447006842	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006843	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447006844	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447006845	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
449447006846	Predicted permeases [General function prediction only]; Region: COG0730
449447006847	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
449447006848	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
449447006849	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
449447006850	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
449447006851	NAD(P) binding site [chemical binding]; other site
449447006852	homotetramer interface [polypeptide binding]; other site
449447006853	homodimer interface [polypeptide binding]; other site
449447006854	active site
449447006855	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447006856	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
449447006857	putative acyl-acceptor binding pocket; other site
449447006858	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447006859	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
449447006860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447006861	S-adenosylmethionine binding site [chemical binding]; other site
449447006862	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
449447006863	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
449447006864	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
449447006865	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
449447006866	serine O-acetyltransferase; Region: cysE; TIGR01172
449447006867	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447006868	trimer interface [polypeptide binding]; other site
449447006869	active site
449447006870	substrate binding site [chemical binding]; other site
449447006871	CoA binding site [chemical binding]; other site
449447006872	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
449447006873	Glycoprotease family; Region: Peptidase_M22; pfam00814
449447006874	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
449447006875	active site
449447006876	catalytic residues [active]
449447006877	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
449447006878	Haemolytic domain; Region: Haemolytic; pfam01809
449447006879	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447006880	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
449447006881	active site
449447006882	catalytic residues [active]
449447006883	DNA binding site [nucleotide binding]
449447006884	Int/Topo IB signature motif; other site
449447006885	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006887	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006888	Paired Box domain; Region: PAX; cd00131
449447006889	DNA binding site [nucleotide binding]
449447006890	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006891	Homeodomain-like domain; Region: HTH_32; pfam13565
449447006892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447006893	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447006894	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006895	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006896	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
449447006897	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447006898	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447006899	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447006900	non-specific DNA binding site [nucleotide binding]; other site
449447006901	salt bridge; other site
449447006902	sequence-specific DNA binding site [nucleotide binding]; other site
449447006903	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
449447006904	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447006905	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447006906	active site
449447006907	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006908	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006909	Homeodomain-like domain; Region: HTH_32; pfam13565
449447006910	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006911	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006912	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447006913	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006914	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447006915	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447006916	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447006917	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006918	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447006919	Double zinc ribbon; Region: DZR; pfam12773
449447006920	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
449447006921	Double zinc ribbon; Region: DZR; pfam12773
449447006922	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006923	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447006924	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006925	Transposase [DNA replication, recombination, and repair]; Region: COG5433
449447006926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447006927	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447006928	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447006929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447006930	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447006931	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447006932	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447006933	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
449447006934	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
449447006935	C-terminal domain interface [polypeptide binding]; other site
449447006936	active site
449447006937	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
449447006938	active site
449447006939	N-terminal domain interface [polypeptide binding]; other site
449447006940	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447006941	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447006942	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
449447006943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447006944	non-specific DNA binding site [nucleotide binding]; other site
449447006945	salt bridge; other site
449447006946	sequence-specific DNA binding site [nucleotide binding]; other site
449447006947	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447006948	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
449447006949	PemK-like protein; Region: PemK; pfam02452
449447006950	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
449447006951	putative active site [active]
449447006952	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
449447006953	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
449447006954	putative di-iron ligands [ion binding]; other site
449447006955	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447006956	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447006957	cofactor binding site; other site
449447006958	DNA binding site [nucleotide binding]
449447006959	substrate interaction site [chemical binding]; other site
449447006960	Homeodomain-like domain; Region: HTH_23; pfam13384
449447006961	Winged helix-turn helix; Region: HTH_29; pfam13551
449447006962	Winged helix-turn helix; Region: HTH_33; pfam13592
449447006963	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447006964	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447006965	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
449447006966	putative active site [active]
449447006967	AAA ATPase domain; Region: AAA_16; pfam13191
449447006968	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447006969	G1 box; other site
449447006970	GTP/Mg2+ binding site [chemical binding]; other site
449447006971	G2 box; other site
449447006972	Switch I region; other site
449447006973	G3 box; other site
449447006974	Switch II region; other site
449447006975	G4 box; other site
449447006976	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447006977	Uncharacterized conserved protein [Function unknown]; Region: COG2442
449447006978	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447006979	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447006980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447006981	putative phosphoketolase; Provisional; Region: PRK05261
449447006982	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
449447006983	TPP-binding site; other site
449447006984	XFP C-terminal domain; Region: XFP_C; pfam09363
449447006985	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
449447006986	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
449447006987	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
449447006988	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
449447006989	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
449447006990	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
449447006991	NAD synthetase; Provisional; Region: PRK13981
449447006992	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
449447006993	multimer interface [polypeptide binding]; other site
449447006994	active site
449447006995	catalytic triad [active]
449447006996	protein interface 1 [polypeptide binding]; other site
449447006997	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
449447006998	homodimer interface [polypeptide binding]; other site
449447006999	NAD binding pocket [chemical binding]; other site
449447007000	ATP binding pocket [chemical binding]; other site
449447007001	Mg binding site [ion binding]; other site
449447007002	active-site loop [active]
449447007003	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
449447007004	nudix motif; other site
449447007005	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
449447007006	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
449447007007	active site
449447007008	(T/H)XGH motif; other site
449447007009	RES domain; Region: RES; pfam08808
449447007010	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
449447007011	HEAT repeats; Region: HEAT_2; pfam13646
449447007012	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
449447007013	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447007014	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447007015	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447007016	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007017	putative active site [active]
449447007018	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447007019	TrkA-N domain; Region: TrkA_N; pfam02254
449447007020	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
449447007021	TrkA-N domain; Region: TrkA_N; pfam02254
449447007022	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447007023	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447007024	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
449447007025	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
449447007026	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
449447007027	active site
449447007028	catalytic site [active]
449447007029	enolase; Provisional; Region: eno; PRK00077
449447007030	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
449447007031	dimer interface [polypeptide binding]; other site
449447007032	metal binding site [ion binding]; metal-binding site
449447007033	substrate binding pocket [chemical binding]; other site
449447007034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007035	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007036	Probable transposase; Region: OrfB_IS605; pfam01385
449447007037	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007038	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
449447007039	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
449447007040	Rrf2 family protein; Region: rrf2_super; TIGR00738
449447007041	Transcriptional regulator; Region: Rrf2; pfam02082
449447007042	Uncharacterized conserved protein [Function unknown]; Region: COG3791
449447007043	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
449447007044	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447007045	Transposase domain (DUF772); Region: DUF772; pfam05598
449447007046	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447007047	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447007048	putative acyl-acceptor binding pocket; other site
449447007049	Paired Box domain; Region: PAX; cd00131
449447007050	DNA binding site [nucleotide binding]
449447007051	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007052	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447007054	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007055	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007056	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007057	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007058	Homeodomain-like domain; Region: HTH_23; pfam13384
449447007059	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007060	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007061	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007062	aspartate aminotransferase; Provisional; Region: PRK05764
449447007063	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447007064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007065	homodimer interface [polypeptide binding]; other site
449447007066	catalytic residue [active]
449447007067	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447007068	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447007069	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007070	Integrase core domain; Region: rve; pfam00665
449447007071	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
449447007072	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
449447007073	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447007074	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447007075	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007076	Integrase core domain; Region: rve; pfam00665
449447007077	AAA ATPase domain; Region: AAA_16; pfam13191
449447007078	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447007079	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447007080	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447007081	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
449447007082	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
449447007083	putative tRNA-binding site [nucleotide binding]; other site
449447007084	B3/4 domain; Region: B3_4; pfam03483
449447007085	tRNA synthetase B5 domain; Region: B5; smart00874
449447007086	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
449447007087	dimer interface [polypeptide binding]; other site
449447007088	motif 1; other site
449447007089	motif 3; other site
449447007090	motif 2; other site
449447007091	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
449447007092	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447007093	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447007094	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
449447007095	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
449447007096	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
449447007097	Walker A/P-loop; other site
449447007098	ATP binding site [chemical binding]; other site
449447007099	Q-loop/lid; other site
449447007100	ABC transporter signature motif; other site
449447007101	Walker B; other site
449447007102	D-loop; other site
449447007103	H-loop/switch region; other site
449447007104	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
449447007105	mce related protein; Region: MCE; pfam02470
449447007106	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447007107	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
449447007108	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447007109	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447007110	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007111	structural tetrad; other site
449447007112	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007113	putative active site [active]
449447007114	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
449447007115	UbiA prenyltransferase family; Region: UbiA; pfam01040
449447007116	HAS barrel domain; Region: HAS-barrel; pfam09378
449447007117	HerA helicase [Replication, recombination, and repair]; Region: COG0433
449447007118	Domain of unknown function DUF87; Region: DUF87; pfam01935
449447007119	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447007120	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
449447007121	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
449447007122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007123	S-adenosylmethionine binding site [chemical binding]; other site
449447007124	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
449447007125	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
449447007126	Mg2+ binding site [ion binding]; other site
449447007127	G-X-G motif; other site
449447007128	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447007129	EamA-like transporter family; Region: EamA; pfam00892
449447007130	EamA-like transporter family; Region: EamA; pfam00892
449447007131	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
449447007132	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
449447007133	GUN4-like; Region: GUN4; pfam05419
449447007134	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
449447007135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447007136	putative substrate translocation pore; other site
449447007137	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447007138	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
449447007139	dimer interface [polypeptide binding]; other site
449447007140	decamer (pentamer of dimers) interface [polypeptide binding]; other site
449447007141	catalytic triad [active]
449447007142	peroxidatic and resolving cysteines [active]
449447007143	Homeodomain-like domain; Region: HTH_23; pfam13384
449447007144	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007145	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007146	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447007147	ligand binding site [chemical binding]; other site
449447007148	flexible hinge region; other site
449447007149	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447007150	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
449447007151	putative active site [active]
449447007152	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447007153	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447007154	Walker A/P-loop; other site
449447007155	ATP binding site [chemical binding]; other site
449447007156	Q-loop/lid; other site
449447007157	ABC transporter signature motif; other site
449447007158	Walker B; other site
449447007159	D-loop; other site
449447007160	H-loop/switch region; other site
449447007161	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
449447007162	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
449447007163	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447007164	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
449447007165	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
449447007166	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
449447007167	toxin interface [polypeptide binding]; other site
449447007168	Zn binding site [ion binding]; other site
449447007169	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447007170	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447007171	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447007172	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447007173	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
449447007174	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
449447007175	toxin interface [polypeptide binding]; other site
449447007176	Zn binding site [ion binding]; other site
449447007177	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007178	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
449447007179	toxin interface [polypeptide binding]; other site
449447007180	Zn binding site [ion binding]; other site
449447007181	TPR repeat; Region: TPR_11; pfam13414
449447007182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007183	binding surface
449447007184	TPR motif; other site
449447007185	TPR repeat; Region: TPR_11; pfam13414
449447007186	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
449447007187	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
449447007188	active site
449447007189	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
449447007190	homodecamer interface [polypeptide binding]; other site
449447007191	GTP cyclohydrolase I; Provisional; Region: PLN03044
449447007192	active site
449447007193	putative catalytic site residues [active]
449447007194	zinc binding site [ion binding]; other site
449447007195	GTP-CH-I/GFRP interaction surface; other site
449447007196	short chain dehydrogenase; Provisional; Region: PRK07454
449447007197	classical (c) SDRs; Region: SDR_c; cd05233
449447007198	NAD(P) binding site [chemical binding]; other site
449447007199	active site
449447007200	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
449447007201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
449447007202	dimerization interface [polypeptide binding]; other site
449447007203	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
449447007204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
449447007205	putative active site [active]
449447007206	heme pocket [chemical binding]; other site
449447007207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447007208	dimer interface [polypeptide binding]; other site
449447007209	phosphorylation site [posttranslational modification]
449447007210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447007211	ATP binding site [chemical binding]; other site
449447007212	Mg2+ binding site [ion binding]; other site
449447007213	G-X-G motif; other site
449447007214	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
449447007215	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447007216	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
449447007217	putative ADP-binding pocket [chemical binding]; other site
449447007218	proton extrusion protein PcxA; Provisional; Region: PRK02507
449447007219	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447007220	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
449447007221	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
449447007222	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
449447007223	Walker A/P-loop; other site
449447007224	ATP binding site [chemical binding]; other site
449447007225	Q-loop/lid; other site
449447007226	ABC transporter signature motif; other site
449447007227	Walker B; other site
449447007228	D-loop; other site
449447007229	H-loop/switch region; other site
449447007230	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447007231	Uncharacterized conserved protein [Function unknown]; Region: COG4748
449447007232	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447007233	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007234	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
449447007235	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
449447007236	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447007237	active site
449447007238	Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Region: NodZ_like; cd11548
449447007239	GDP-Fucose binding site [chemical binding]; other site
449447007240	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
449447007241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007242	Probable transposase; Region: OrfB_IS605; pfam01385
449447007243	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
449447007244	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
449447007245	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
449447007246	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
449447007247	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447007248	substrate binding pocket [chemical binding]; other site
449447007249	membrane-bound complex binding site; other site
449447007250	hinge residues; other site
449447007251	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447007252	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447007253	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447007254	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447007255	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447007256	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007257	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447007258	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447007259	DNA-binding interface [nucleotide binding]; DNA binding site
449447007260	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447007262	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447007263	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447007264	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007265	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007266	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007267	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
449447007268	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
449447007269	FMN binding site [chemical binding]; other site
449447007270	active site
449447007271	substrate binding site [chemical binding]; other site
449447007272	catalytic residue [active]
449447007273	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447007274	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
449447007275	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
449447007276	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447007277	FeS/SAM binding site; other site
449447007278	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
449447007279	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447007280	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447007281	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
449447007282	putative ADP-binding pocket [chemical binding]; other site
449447007283	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007284	TPR repeat; Region: TPR_11; pfam13414
449447007285	binding surface
449447007286	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447007287	L-aspartate oxidase; Provisional; Region: PRK07395
449447007288	L-aspartate oxidase; Provisional; Region: PRK06175
449447007289	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
449447007290	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
449447007291	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447007292	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
449447007293	dimer interface [polypeptide binding]; other site
449447007294	decamer (pentamer of dimers) interface [polypeptide binding]; other site
449447007295	catalytic triad [active]
449447007296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007297	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007298	Probable transposase; Region: OrfB_IS605; pfam01385
449447007299	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007300	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447007301	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447007302	catalytic loop [active]
449447007303	iron binding site [ion binding]; other site
449447007304	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
449447007305	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
449447007306	active site
449447007307	catalytic site [active]
449447007308	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
449447007309	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
449447007310	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
449447007311	active site clefts [active]
449447007312	zinc binding site [ion binding]; other site
449447007313	dimer interface [polypeptide binding]; other site
449447007314	Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605
449447007315	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
449447007316	active site clefts [active]
449447007317	zinc binding site [ion binding]; other site
449447007318	dimer interface [polypeptide binding]; other site
449447007319	ribosomal protein L19; Region: rpl19; CHL00084
449447007320	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
449447007321	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
449447007322	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
449447007323	putative homodimer interface [polypeptide binding]; other site
449447007324	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
449447007325	heterodimer interface [polypeptide binding]; other site
449447007326	homodimer interface [polypeptide binding]; other site
449447007327	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
449447007328	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
449447007329	23S rRNA interface [nucleotide binding]; other site
449447007330	L7/L12 interface [polypeptide binding]; other site
449447007331	putative thiostrepton binding site; other site
449447007332	L25 interface [polypeptide binding]; other site
449447007333	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
449447007334	mRNA/rRNA interface [nucleotide binding]; other site
449447007335	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447007336	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447007337	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322
449447007338	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
449447007339	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
449447007340	active site
449447007341	Riboflavin kinase; Region: Flavokinase; pfam01687
449447007342	MoxR-like ATPases [General function prediction only]; Region: COG0714
449447007343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007344	Walker A motif; other site
449447007345	ATP binding site [chemical binding]; other site
449447007346	Walker B motif; other site
449447007347	arginine finger; other site
449447007348	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
449447007349	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
449447007350	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
449447007351	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
449447007352	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447007353	active site
449447007354	metal binding site [ion binding]; metal-binding site
449447007355	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
449447007356	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
449447007357	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
449447007358	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
449447007359	dimer interface [polypeptide binding]; other site
449447007360	PYR/PP interface [polypeptide binding]; other site
449447007361	TPP binding site [chemical binding]; other site
449447007362	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
449447007363	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
449447007364	TPP-binding site [chemical binding]; other site
449447007365	dimer interface [polypeptide binding]; other site
449447007366	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
449447007367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447007368	Walker A/P-loop; other site
449447007369	ATP binding site [chemical binding]; other site
449447007370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447007371	ABC transporter signature motif; other site
449447007372	Walker B; other site
449447007373	D-loop; other site
449447007374	H-loop/switch region; other site
449447007375	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
449447007376	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
449447007377	Cupin domain; Region: Cupin_2; pfam07883
449447007378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
449447007379	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007381	S-adenosylmethionine binding site [chemical binding]; other site
449447007382	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
449447007383	active site
449447007384	iron coordination sites [ion binding]; other site
449447007385	substrate binding pocket [chemical binding]; other site
449447007386	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
449447007387	NADPH bind site [chemical binding]; other site
449447007388	putative FMN binding site [chemical binding]; other site
449447007389	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
449447007390	putative FMN binding site [chemical binding]; other site
449447007391	NADPH bind site [chemical binding]; other site
449447007392	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447007393	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007394	putative active site [active]
449447007395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
449447007396	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
449447007397	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447007398	Cupin domain; Region: Cupin_2; cl17218
449447007399	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
449447007400	homotrimer interface [polypeptide binding]; other site
449447007401	Walker A motif; other site
449447007402	GTP binding site [chemical binding]; other site
449447007403	Walker B motif; other site
449447007404	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447007405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007406	S-adenosylmethionine binding site [chemical binding]; other site
449447007407	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
449447007408	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
449447007409	substrate binding site [chemical binding]; other site
449447007410	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
449447007411	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447007412	Walker A/P-loop; other site
449447007413	ATP binding site [chemical binding]; other site
449447007414	Predicted membrane protein [Function unknown]; Region: COG1289
449447007415	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
449447007416	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
449447007417	Bacterial Ig-like domain; Region: Big_5; pfam13205
449447007418	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
449447007419	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
449447007420	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
449447007421	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447007422	metal binding site 2 [ion binding]; metal-binding site
449447007423	putative DNA binding helix; other site
449447007424	metal binding site 1 [ion binding]; metal-binding site
449447007425	dimer interface [polypeptide binding]; other site
449447007426	structural Zn2+ binding site [ion binding]; other site
449447007427	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
449447007428	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447007429	HSP70 interaction site [polypeptide binding]; other site
449447007430	TPR repeat; Region: TPR_11; pfam13414
449447007431	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447007432	binding surface
449447007433	TPR motif; other site
449447007434	TPR repeat; Region: TPR_11; pfam13414
449447007435	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
449447007436	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
449447007437	inhibitor-cofactor binding pocket; inhibition site
449447007438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007439	catalytic residue [active]
449447007440	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
449447007441	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
449447007442	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
449447007443	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
449447007444	SLBB domain; Region: SLBB; pfam10531
449447007445	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447007446	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
449447007447	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447007448	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
449447007449	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
449447007450	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
449447007451	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007452	P loop; other site
449447007453	Nucleotide binding site [chemical binding]; other site
449447007454	DTAP/Switch II; other site
449447007455	Switch I; other site
449447007456	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007457	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
449447007458	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
449447007459	tetramerization interface [polypeptide binding]; other site
449447007460	active site
449447007461	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
449447007462	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
449447007463	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
449447007464	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
449447007465	dimer interface [polypeptide binding]; other site
449447007466	anticodon binding site; other site
449447007467	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
449447007468	homodimer interface [polypeptide binding]; other site
449447007469	motif 1; other site
449447007470	active site
449447007471	motif 2; other site
449447007472	GAD domain; Region: GAD; pfam02938
449447007473	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
449447007474	active site
449447007475	motif 3; other site
449447007476	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447007477	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447007478	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
449447007479	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
449447007480	TIR domain; Region: TIR_2; pfam13676
449447007481	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447007482	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447007483	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447007484	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
449447007485	four helix bundle protein; Region: TIGR02436
449447007486	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
449447007487	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447007488	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447007489	active site
449447007490	catalytic tetrad [active]
449447007491	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
449447007492	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
449447007493	Helix-turn-helix domain; Region: HTH_25; pfam13413
449447007494	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
449447007495	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
449447007496	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447007497	RNA binding surface [nucleotide binding]; other site
449447007498	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
449447007499	active site
449447007500	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
449447007501	homotetrameric interface [polypeptide binding]; other site
449447007502	putative active site [active]
449447007503	metal binding site [ion binding]; metal-binding site
449447007504	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447007505	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007506	structural tetrad; other site
449447007507	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447007508	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007509	structural tetrad; other site
449447007510	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
449447007511	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
449447007512	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447007513	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447007514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447007515	motif II; other site
449447007516	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447007517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447007518	active site
449447007519	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447007520	phosphorylation site [posttranslational modification]
449447007521	intermolecular recognition site; other site
449447007522	dimerization interface [polypeptide binding]; other site
449447007523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447007524	dimer interface [polypeptide binding]; other site
449447007525	phosphorylation site [posttranslational modification]
449447007526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447007527	ATP binding site [chemical binding]; other site
449447007528	Mg2+ binding site [ion binding]; other site
449447007529	G-X-G motif; other site
449447007530	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007531	O-Antigen ligase; Region: Wzy_C; cl04850
449447007532	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
449447007533	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
449447007534	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
449447007535	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
449447007536	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
449447007537	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
449447007538	generic binding surface I; other site
449447007539	generic binding surface II; other site
449447007540	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
449447007541	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
449447007542	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
449447007543	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
449447007544	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
449447007545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007546	Walker A motif; other site
449447007547	ATP binding site [chemical binding]; other site
449447007548	Walker B motif; other site
449447007549	arginine finger; other site
449447007550	Gas vesicle protein; Region: Gas_vesicle; pfam00741
449447007551	Gas vesicle protein K; Region: GvpK; pfam05121
449447007552	Gas vesicle protein; Region: Gas_vesicle; pfam00741
449447007553	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
449447007554	Gas vesicle protein G; Region: GvpG; pfam05120
449447007555	Protein of unknown function (DUF342); Region: DUF342; pfam03961
449447007556	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
449447007557	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
449447007558	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007559	P loop; other site
449447007560	Nucleotide binding site [chemical binding]; other site
449447007561	DTAP/Switch II; other site
449447007562	Switch I; other site
449447007563	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
449447007564	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
449447007565	DTAP/Switch II; other site
449447007566	Switch I; other site
449447007567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007568	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
449447007569	Walker A motif; other site
449447007570	ATP binding site [chemical binding]; other site
449447007571	Walker B motif; other site
449447007572	arginine finger; other site
449447007573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447007574	Walker A motif; other site
449447007575	ATP binding site [chemical binding]; other site
449447007576	Walker B motif; other site
449447007577	arginine finger; other site
449447007578	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
449447007579	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
449447007580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447007581	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
449447007582	glutaminase A; Region: Gln_ase; TIGR03814
449447007583	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
449447007584	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
449447007585	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
449447007586	shikimate binding site; other site
449447007587	NAD(P) binding site [chemical binding]; other site
449447007588	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447007589	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447007590	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
449447007591	EamA-like transporter family; Region: EamA; pfam00892
449447007592	EamA-like transporter family; Region: EamA; pfam00892
449447007593	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447007594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007595	S-adenosylmethionine binding site [chemical binding]; other site
449447007596	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
449447007597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447007598	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
449447007599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007600	S-adenosylmethionine binding site [chemical binding]; other site
449447007601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
449447007602	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
449447007603	Repair protein; Region: Repair_PSII; pfam04536
449447007604	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
449447007605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007606	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007607	Probable transposase; Region: OrfB_IS605; pfam01385
449447007608	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007609	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447007610	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447007611	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447007612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447007613	dimer interface [polypeptide binding]; other site
449447007614	conserved gate region; other site
449447007615	putative PBP binding loops; other site
449447007616	ABC-ATPase subunit interface; other site
449447007617	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
449447007618	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
449447007619	dimer interface [polypeptide binding]; other site
449447007620	ssDNA binding site [nucleotide binding]; other site
449447007621	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447007622	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447007623	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
449447007624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007625	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007626	Probable transposase; Region: OrfB_IS605; pfam01385
449447007627	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007628	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
449447007629	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
449447007630	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007631	Probable transposase; Region: OrfB_IS605; pfam01385
449447007632	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007633	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447007634	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447007635	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007636	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007637	Probable transposase; Region: OrfB_IS605; pfam01385
449447007638	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007639	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007640	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
449447007641	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
449447007642	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
449447007643	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
449447007644	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
449447007645	Catalytic site [active]
449447007646	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
449447007647	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
449447007648	dimer interface [polypeptide binding]; other site
449447007649	PYR/PP interface [polypeptide binding]; other site
449447007650	TPP binding site [chemical binding]; other site
449447007651	substrate binding site [chemical binding]; other site
449447007652	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
449447007653	Domain of unknown function; Region: EKR; pfam10371
449447007654	4Fe-4S binding domain; Region: Fer4_6; pfam12837
449447007655	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447007656	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
449447007657	TPP-binding site [chemical binding]; other site
449447007658	dimer interface [polypeptide binding]; other site
449447007659	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
449447007660	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
449447007661	putative active site [active]
449447007662	putative FMN binding site [chemical binding]; other site
449447007663	putative substrate binding site [chemical binding]; other site
449447007664	6-phosphofructokinase; Provisional; Region: PRK03202
449447007665	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
449447007666	active site
449447007667	ADP/pyrophosphate binding site [chemical binding]; other site
449447007668	dimerization interface [polypeptide binding]; other site
449447007669	allosteric effector site; other site
449447007670	fructose-1,6-bisphosphate binding site; other site
449447007671	YcfA-like protein; Region: YcfA; pfam07927
449447007672	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447007673	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447007674	structural tetrad; other site
449447007675	PQQ-like domain; Region: PQQ_2; pfam13360
449447007676	WD40 repeats; Region: WD40; smart00320
449447007677	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
449447007678	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447007679	PBP superfamily domain; Region: PBP_like_2; pfam12849
449447007680	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
449447007681	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
449447007682	amidohydrolase; Region: amidohydrolases; TIGR01891
449447007683	metal binding site [ion binding]; metal-binding site
449447007684	dimer interface [polypeptide binding]; other site
449447007685	MEKHLA domain; Region: MEKHLA; pfam08670
449447007686	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
449447007687	active site
449447007688	dimer interface [polypeptide binding]; other site
449447007689	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
449447007690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007691	S-adenosylmethionine binding site [chemical binding]; other site
449447007692	Tic22-like family; Region: Tic22; pfam04278
449447007693	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
449447007694	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
449447007695	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447007696	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447007697	DNA-binding interface [nucleotide binding]; DNA binding site
449447007698	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447007700	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447007701	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447007702	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447007703	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447007704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447007705	active site
449447007706	phosphorylation site [posttranslational modification]
449447007707	intermolecular recognition site; other site
449447007708	dimerization interface [polypeptide binding]; other site
449447007709	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447007710	DNA binding residues [nucleotide binding]
449447007711	dimerization interface [polypeptide binding]; other site
449447007712	phosphoribulokinase; Provisional; Region: PRK07429
449447007713	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
449447007714	active site
449447007715	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447007716	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447007717	Probable transposase; Region: OrfB_IS605; pfam01385
449447007718	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447007719	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447007720	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447007721	phosphopeptide binding site; other site
449447007722	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
449447007723	metal binding site [ion binding]; metal-binding site
449447007724	active site
449447007725	I-site; other site
449447007726	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
449447007727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
449447007728	Predicted kinase [General function prediction only]; Region: COG0645
449447007729	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
449447007730	ATP-binding site [chemical binding]; other site
449447007731	Gluconate-6-phosphate binding site [chemical binding]; other site
449447007732	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007733	putative active site [active]
449447007734	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007735	putative active site [active]
449447007736	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
449447007737	Condensation domain; Region: Condensation; pfam00668
449447007738	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007739	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007740	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447007741	acyl-activating enzyme (AAE) consensus motif; other site
449447007742	AMP binding site [chemical binding]; other site
449447007743	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007744	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
449447007745	Condensation domain; Region: Condensation; pfam00668
449447007746	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007747	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007748	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447007749	acyl-activating enzyme (AAE) consensus motif; other site
449447007750	AMP binding site [chemical binding]; other site
449447007751	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007752	Condensation domain; Region: Condensation; pfam00668
449447007753	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007754	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007755	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447007756	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447007757	acyl-activating enzyme (AAE) consensus motif; other site
449447007758	AMP binding site [chemical binding]; other site
449447007759	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007760	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447007761	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
449447007762	acyl-activating enzyme (AAE) consensus motif; other site
449447007763	AMP binding site [chemical binding]; other site
449447007764	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007766	S-adenosylmethionine binding site [chemical binding]; other site
449447007767	Microcystin synthetase C terminal; Region: McyA_C; pfam12593
449447007768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447007769	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007770	Condensation domain; Region: Condensation; pfam00668
449447007771	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007772	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
449447007773	acyl-activating enzyme (AAE) consensus motif; other site
449447007774	AMP binding site [chemical binding]; other site
449447007775	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007776	Condensation domain; Region: Condensation; pfam00668
449447007777	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447007778	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007779	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007780	active site
449447007781	Acyl transferase domain; Region: Acyl_transf_1; cl08282
449447007782	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
449447007783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007784	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007785	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007786	putative NADP binding site [chemical binding]; other site
449447007787	KR domain; Region: KR; pfam08659
449447007788	active site
449447007789	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447007790	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
449447007791	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007792	active site
449447007793	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447007794	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
449447007795	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007796	KR domain; Region: KR; pfam08659
449447007797	putative NADP binding site [chemical binding]; other site
449447007798	active site
449447007799	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447007800	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007801	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007802	active site
449447007803	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447007804	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447007805	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007806	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447007807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007808	S-adenosylmethionine binding site [chemical binding]; other site
449447007809	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447007810	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
449447007811	inhibitor-cofactor binding pocket; inhibition site
449447007812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007813	catalytic residue [active]
449447007814	Condensation domain; Region: Condensation; pfam00668
449447007815	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007816	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007817	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447007818	acyl-activating enzyme (AAE) consensus motif; other site
449447007819	AMP binding site [chemical binding]; other site
449447007820	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007821	Condensation domain; Region: Condensation; pfam00668
449447007822	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447007823	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447007824	aspartate racemase; Region: asp_race; TIGR00035
449447007825	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
449447007826	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
449447007827	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
449447007828	acyl-activating enzyme (AAE) consensus motif; other site
449447007829	putative AMP binding site [chemical binding]; other site
449447007830	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447007831	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
449447007832	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
449447007833	active site
449447007834	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
449447007835	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
449447007836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007837	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007838	S-adenosylmethionine binding site [chemical binding]; other site
449447007839	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
449447007840	KR domain; Region: KR; pfam08659
449447007841	putative NADP binding site [chemical binding]; other site
449447007842	active site
449447007843	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
449447007844	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447007845	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
449447007846	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
449447007847	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
449447007848	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
449447007849	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
449447007850	ligand binding site [chemical binding]; other site
449447007851	NAD binding site [chemical binding]; other site
449447007852	dimerization interface [polypeptide binding]; other site
449447007853	catalytic site [active]
449447007854	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447007855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447007856	S-adenosylmethionine binding site [chemical binding]; other site
449447007857	DNA polymerase III subunit beta; Validated; Region: PRK05643
449447007858	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
449447007859	putative DNA binding surface [nucleotide binding]; other site
449447007860	dimer interface [polypeptide binding]; other site
449447007861	beta-clamp/clamp loader binding surface; other site
449447007862	beta-clamp/translesion DNA polymerase binding surface; other site
449447007863	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
449447007864	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
449447007865	inhibitor-cofactor binding pocket; inhibition site
449447007866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007867	catalytic residue [active]
449447007868	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
449447007869	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
449447007870	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
449447007871	Cl- selectivity filter; other site
449447007872	Cl- binding residues [ion binding]; other site
449447007873	pore gating glutamate residue; other site
449447007874	dimer interface [polypeptide binding]; other site
449447007875	H+/Cl- coupling transport residue; other site
449447007876	FOG: CBS domain [General function prediction only]; Region: COG0517
449447007877	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
449447007878	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
449447007879	Ligand Binding Site [chemical binding]; other site
449447007880	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447007881	Ligand Binding Site [chemical binding]; other site
449447007882	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447007883	putative active site [active]
449447007884	large terminase protein; Provisional; Region: 17; PHA02533
449447007885	Haemolysin XhlA; Region: XhlA; pfam10779
449447007886	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447007887	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
449447007888	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
449447007889	Mg++ binding site [ion binding]; other site
449447007890	putative catalytic motif [active]
449447007891	substrate binding site [chemical binding]; other site
449447007892	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
449447007893	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
449447007894	dimer interface [polypeptide binding]; other site
449447007895	active site
449447007896	glycine-pyridoxal phosphate binding site [chemical binding]; other site
449447007897	folate binding site [chemical binding]; other site
449447007898	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
449447007899	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
449447007900	Septum formation topological specificity factor MinE; Region: MinE; cl00538
449447007901	septum site-determining protein MinD; Region: minD_bact; TIGR01968
449447007902	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
449447007903	Switch I; other site
449447007904	Switch II; other site
449447007905	septum formation inhibitor; Reviewed; Region: minC; PRK00513
449447007906	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
449447007907	Haemolysin XhlA; Region: XhlA; pfam10779
449447007908	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
449447007909	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
449447007910	addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607
449447007911	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007912	Homeodomain-like domain; Region: HTH_23; pfam13384
449447007913	Winged helix-turn helix; Region: HTH_29; pfam13551
449447007914	Homeodomain-like domain; Region: HTH_32; pfam13565
449447007915	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447007916	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447007917	DNA-binding interface [nucleotide binding]; DNA binding site
449447007918	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447007919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447007920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
449447007921	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
449447007922	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
449447007923	active site
449447007924	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
449447007925	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
449447007926	glycine dehydrogenase; Provisional; Region: PRK05367
449447007927	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
449447007928	tetramer interface [polypeptide binding]; other site
449447007929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007930	catalytic residue [active]
449447007931	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
449447007932	tetramer interface [polypeptide binding]; other site
449447007933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007934	catalytic residue [active]
449447007935	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
449447007936	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447007937	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
449447007938	homodimer interface [polypeptide binding]; other site
449447007939	substrate-cofactor binding pocket; other site
449447007940	Aminotransferase class IV; Region: Aminotran_4; pfam01063
449447007941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447007942	catalytic residue [active]
449447007943	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
449447007944	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
449447007945	dimer interface [polypeptide binding]; other site
449447007946	ssDNA binding site [nucleotide binding]; other site
449447007947	tetramer (dimer of dimers) interface [polypeptide binding]; other site
449447007948	rod shape-determining protein MreB; Provisional; Region: PRK13927
449447007949	MreB and similar proteins; Region: MreB_like; cd10225
449447007950	nucleotide binding site [chemical binding]; other site
449447007951	Mg binding site [ion binding]; other site
449447007952	putative protofilament interaction site [polypeptide binding]; other site
449447007953	RodZ interaction site [polypeptide binding]; other site
449447007954	rod shape-determining protein MreC; Provisional; Region: PRK13922
449447007955	rod shape-determining protein MreC; Region: MreC; pfam04085
449447007956	Transglycosylase; Region: Transgly; pfam00912
449447007957	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447007958	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
449447007959	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
449447007960	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
449447007961	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
449447007962	protein binding site [polypeptide binding]; other site
449447007963	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
449447007964	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
449447007965	homodimer interface [polypeptide binding]; other site
449447007966	substrate-cofactor binding pocket; other site
449447007967	catalytic residue [active]
449447007968	circadian clock protein KaiC; Reviewed; Region: PRK09302
449447007969	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
449447007970	Walker A motif; other site
449447007971	ATP binding site [chemical binding]; other site
449447007972	Walker B motif; other site
449447007973	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447007974	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447007975	Walker A motif; other site
449447007976	Walker A motif; other site
449447007977	ATP binding site [chemical binding]; other site
449447007978	Walker B motif; other site
449447007979	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447007980	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447007981	substrate binding pocket [chemical binding]; other site
449447007982	membrane-bound complex binding site; other site
449447007983	hinge residues; other site
449447007984	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
449447007985	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
449447007986	active site
449447007987	PHP Thumb interface [polypeptide binding]; other site
449447007988	metal binding site [ion binding]; metal-binding site
449447007989	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
449447007990	protein-splicing catalytic site; other site
449447007991	thioester formation/cholesterol transfer; other site
449447007992	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
449447007993	putative binding surface; other site
449447007994	active site
449447007995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447007996	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447007997	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
449447007998	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
449447007999	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
449447008000	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
449447008001	Surface antigen; Region: Bac_surface_Ag; pfam01103
449447008002	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
449447008003	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
449447008004	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
449447008005	diiron binding motif [ion binding]; other site
449447008006	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447008007	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
449447008008	Clp amino terminal domain; Region: Clp_N; pfam02861
449447008009	Clp amino terminal domain; Region: Clp_N; pfam02861
449447008010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447008011	Walker A motif; other site
449447008012	ATP binding site [chemical binding]; other site
449447008013	Walker B motif; other site
449447008014	arginine finger; other site
449447008015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447008016	Walker A motif; other site
449447008017	ATP binding site [chemical binding]; other site
449447008018	Walker B motif; other site
449447008019	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
449447008020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447008021	Coenzyme A binding pocket [chemical binding]; other site
449447008022	GLTT repeat (6 copies); Region: GLTT; pfam01744
449447008023	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
449447008024	FAD binding site [chemical binding]; other site
449447008025	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
449447008026	active site
449447008027	catalytic triad [active]
449447008028	oxyanion hole [active]
449447008029	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447008030	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447008031	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447008032	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447008033	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008034	Homeodomain-like domain; Region: HTH_23; pfam13384
449447008035	Homeodomain-like domain; Region: HTH_32; pfam13565
449447008036	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447008038	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447008039	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447008040	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447008041	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447008042	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
449447008043	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447008044	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447008045	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447008046	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008047	Homeodomain-like domain; Region: HTH_23; pfam13384
449447008048	Winged helix-turn helix; Region: HTH_33; pfam13592
449447008049	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008050	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447008051	hypothetical protein; Provisional; Region: PRK06922
449447008052	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
449447008053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447008054	ATP binding site [chemical binding]; other site
449447008055	putative Mg++ binding site [ion binding]; other site
449447008056	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447008057	nucleotide binding region [chemical binding]; other site
449447008058	ATP-binding site [chemical binding]; other site
449447008059	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
449447008060	metal-binding heat shock protein; Provisional; Region: PRK00016
449447008061	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
449447008062	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
449447008063	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447008064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447008065	S-adenosylmethionine binding site [chemical binding]; other site
449447008066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008067	AAA domain; Region: AAA_23; pfam13476
449447008068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008069	Walker A/P-loop; other site
449447008070	Walker A/P-loop; other site
449447008071	ATP binding site [chemical binding]; other site
449447008072	ATP binding site [chemical binding]; other site
449447008073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008074	Q-loop/lid; other site
449447008075	ABC transporter signature motif; other site
449447008076	Walker B; other site
449447008077	D-loop; other site
449447008078	H-loop/switch region; other site
449447008079	TIGR02646 family protein; Region: TIGR02646
449447008080	Uncharacterized conserved protein [Function unknown]; Region: COG3937
449447008081	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
449447008082	dimer interface [polypeptide binding]; other site
449447008083	active site
449447008084	Schiff base residues; other site
449447008085	golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522
449447008086	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
449447008087	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447008088	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
449447008089	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447008090	motif II; other site
449447008091	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
449447008092	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447008093	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447008094	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
449447008095	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447008096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008097	Walker A/P-loop; other site
449447008098	ATP binding site [chemical binding]; other site
449447008099	Q-loop/lid; other site
449447008100	ABC transporter signature motif; other site
449447008101	Walker B; other site
449447008102	D-loop; other site
449447008103	H-loop/switch region; other site
449447008104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008106	Walker A/P-loop; other site
449447008107	Walker A/P-loop; other site
449447008108	ATP binding site [chemical binding]; other site
449447008109	ATP binding site [chemical binding]; other site
449447008110	AAA domain; Region: AAA_21; pfam13304
449447008111	GTP-binding protein LepA; Provisional; Region: PRK05433
449447008112	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
449447008113	G1 box; other site
449447008114	putative GEF interaction site [polypeptide binding]; other site
449447008115	GTP/Mg2+ binding site [chemical binding]; other site
449447008116	Switch I region; other site
449447008117	G2 box; other site
449447008118	G3 box; other site
449447008119	Switch II region; other site
449447008120	G4 box; other site
449447008121	G5 box; other site
449447008122	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
449447008123	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
449447008124	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
449447008125	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447008126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447008127	S-adenosylmethionine binding site [chemical binding]; other site
449447008128	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447008129	CHAT domain; Region: CHAT; cl17868
449447008130	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447008131	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447008132	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447008133	CHAT domain; Region: CHAT; cl17868
449447008134	AAA ATPase domain; Region: AAA_16; pfam13191
449447008135	GUN4-like; Region: GUN4; pfam05419
449447008136	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
449447008137	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
449447008138	Dimer interface [polypeptide binding]; other site
449447008139	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
449447008140	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
449447008141	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
449447008142	aromatic arch; other site
449447008143	DCoH dimer interaction site [polypeptide binding]; other site
449447008144	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
449447008145	DCoH tetramer interaction site [polypeptide binding]; other site
449447008146	substrate binding site [chemical binding]; other site
449447008147	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
449447008148	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447008149	ATP binding site [chemical binding]; other site
449447008150	putative Mg++ binding site [ion binding]; other site
449447008151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447008152	nucleotide binding region [chemical binding]; other site
449447008153	ATP-binding site [chemical binding]; other site
449447008154	heat shock protein 90; Provisional; Region: PRK05218
449447008155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008156	ATP binding site [chemical binding]; other site
449447008157	Mg2+ binding site [ion binding]; other site
449447008158	G-X-G motif; other site
449447008159	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
449447008160	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
449447008161	catalytic motif [active]
449447008162	Zn binding site [ion binding]; other site
449447008163	RibD C-terminal domain; Region: RibD_C; cl17279
449447008164	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
449447008165	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
449447008166	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
449447008167	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
449447008168	Ligand binding site; other site
449447008169	Putative Catalytic site; other site
449447008170	DXD motif; other site
449447008171	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447008172	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
449447008173	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
449447008174	active site
449447008175	Zn binding site [ion binding]; other site
449447008176	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
449447008177	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
449447008178	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
449447008179	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447008180	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
449447008181	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447008182	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
449447008183	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447008184	oligomeric interface; other site
449447008185	putative active site [active]
449447008186	homodimer interface [polypeptide binding]; other site
449447008187	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447008188	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
449447008189	Amidinotransferase; Region: Amidinotransf; cl12043
449447008190	Uncharacterized conserved protein [Function unknown]; Region: COG1915
449447008191	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
449447008192	homodimer interface [polypeptide binding]; other site
449447008193	Uncharacterized conserved protein [Function unknown]; Region: COG4715
449447008194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447008195	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008196	Uncharacterized conserved protein [Function unknown]; Region: COG4715
449447008197	SWIM zinc finger; Region: SWIM; pfam04434
449447008198	ParB-like nuclease domain; Region: ParBc; cl02129
449447008199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
449447008200	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
449447008201	dimer interface [polypeptide binding]; other site
449447008202	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
449447008203	PIN domain; Region: PIN_3; cl17397
449447008204	M28 Zn-Peptidases; Region: M28_like_1; cd05640
449447008205	Peptidase family M28; Region: Peptidase_M28; pfam04389
449447008206	metal binding site [ion binding]; metal-binding site
449447008207	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
449447008208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447008209	hydroxyglutarate oxidase; Provisional; Region: PRK11728
449447008210	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447008211	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
449447008212	active site
449447008213	Substrate binding site; other site
449447008214	Mg++ binding site; other site
449447008215	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447008216	putative trimer interface [polypeptide binding]; other site
449447008217	putative CoA binding site [chemical binding]; other site
449447008218	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
449447008219	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
449447008220	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447008222	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447008223	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447008224	Homeodomain-like domain; Region: HTH_32; pfam13565
449447008225	Integrase core domain; Region: rve; pfam00665
449447008226	RDD family; Region: RDD; pfam06271
449447008227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008228	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008229	Probable transposase; Region: OrfB_IS605; pfam01385
449447008230	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008231	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
449447008232	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
449447008233	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447008234	catalytic residue [active]
449447008235	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447008236	putative active site [active]
449447008237	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447008238	Aspartyl protease; Region: Asp_protease_2; pfam13650
449447008239	inhibitor binding site; inhibition site
449447008240	catalytic motif [active]
449447008241	Catalytic residue [active]
449447008242	Active site flap [active]
449447008243	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447008244	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447008245	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447008246	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447008247	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447008248	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
449447008249	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
449447008250	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447008251	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
449447008252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447008253	non-specific DNA binding site [nucleotide binding]; other site
449447008254	salt bridge; other site
449447008255	sequence-specific DNA binding site [nucleotide binding]; other site
449447008256	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
449447008257	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
449447008258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447008259	active site
449447008260	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
449447008261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447008262	dimer interface [polypeptide binding]; other site
449447008263	conserved gate region; other site
449447008264	putative PBP binding loops; other site
449447008265	ABC-ATPase subunit interface; other site
449447008266	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
449447008267	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
449447008268	NADP binding site [chemical binding]; other site
449447008269	active site
449447008270	putative substrate binding site [chemical binding]; other site
449447008271	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
449447008272	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447008273	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
449447008274	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447008275	metal ion-dependent adhesion site (MIDAS); other site
449447008276	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447008277	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447008278	Walker A motif; other site
449447008279	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
449447008280	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447008281	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447008282	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447008283	active site
449447008284	ATP binding site [chemical binding]; other site
449447008285	substrate binding site [chemical binding]; other site
449447008286	activation loop (A-loop); other site
449447008287	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008288	TPR repeat; Region: TPR_11; pfam13414
449447008289	binding surface
449447008290	TPR motif; other site
449447008291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008292	TPR motif; other site
449447008293	binding surface
449447008294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447008295	binding surface
449447008296	TPR motif; other site
449447008297	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008299	binding surface
449447008300	TPR motif; other site
449447008301	TPR repeat; Region: TPR_11; pfam13414
449447008302	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447008303	Protein phosphatase 2C; Region: PP2C; pfam00481
449447008304	active site
449447008305	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
449447008306	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447008307	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447008308	phosphopeptide binding site; other site
449447008309	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447008310	metal ion-dependent adhesion site (MIDAS); other site
449447008311	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447008312	metal ion-dependent adhesion site (MIDAS); other site
449447008313	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
449447008314	metal ion-dependent adhesion site (MIDAS); other site
449447008315	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447008316	Dynamin family; Region: Dynamin_N; pfam00350
449447008317	G1 box; other site
449447008318	GTP/Mg2+ binding site [chemical binding]; other site
449447008319	G2 box; other site
449447008320	Switch I region; other site
449447008321	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447008322	G3 box; other site
449447008323	Switch II region; other site
449447008324	GTP/Mg2+ binding site [chemical binding]; other site
449447008325	G4 box; other site
449447008326	G5 box; other site
449447008327	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
449447008328	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
449447008329	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
449447008330	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
449447008331	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447008332	GUN4-like; Region: GUN4; pfam05419
449447008333	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
449447008334	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
449447008335	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
449447008336	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
449447008337	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
449447008338	Surface antigen; Region: Bac_surface_Ag; pfam01103
449447008339	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
449447008340	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
449447008341	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447008342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008343	phosphorylation site [posttranslational modification]
449447008344	intermolecular recognition site; other site
449447008345	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447008346	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447008347	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
449447008348	CHASE2 domain; Region: CHASE2; pfam05226
449447008349	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
449447008350	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
449447008351	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
449447008352	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008353	putative active site [active]
449447008354	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
449447008355	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
449447008356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008357	binding surface
449447008358	TPR motif; other site
449447008359	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447008360	CHAT domain; Region: CHAT; cl17868
449447008361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447008362	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447008363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
449447008364	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
449447008365	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
449447008366	dimer interface [polypeptide binding]; other site
449447008367	catalytic residues [active]
449447008368	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
449447008369	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
449447008370	IHF dimer interface [polypeptide binding]; other site
449447008371	IHF - DNA interface [nucleotide binding]; other site
449447008372	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
449447008373	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447008374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447008375	homodimer interface [polypeptide binding]; other site
449447008376	catalytic residue [active]
449447008377	photosystem II 44 kDa protein; Region: psbC; CHL00035
449447008378	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
449447008379	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
449447008380	D1 interface; other site
449447008381	chlorophyll binding site; other site
449447008382	pheophytin binding site; other site
449447008383	beta carotene binding site; other site
449447008384	cytochrome b559 beta interface; other site
449447008385	quinone binding site; other site
449447008386	cytochrome b559 alpha interface; other site
449447008387	protein J interface; other site
449447008388	protein H interface; other site
449447008389	protein X interface; other site
449447008390	core light harvesting protein interface; other site
449447008391	protein L interface; other site
449447008392	CP43 interface; other site
449447008393	protein T interface; other site
449447008394	Fe binding site [ion binding]; other site
449447008395	protein M interface; other site
449447008396	Mn-stabilizing polypeptide interface; other site
449447008397	bromide binding site; other site
449447008398	cytochrome c-550 interface; other site
449447008399	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
449447008400	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
449447008401	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
449447008402	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447008403	HSP70 interaction site [polypeptide binding]; other site
449447008404	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
449447008405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447008406	TPR repeat; Region: TPR_11; pfam13414
449447008407	binding surface
449447008408	TPR motif; other site
449447008409	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
449447008410	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
449447008411	active site
449447008412	dimerization interface [polypeptide binding]; other site
449447008413	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447008414	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447008415	catalytic loop [active]
449447008416	iron binding site [ion binding]; other site
449447008417	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
449447008418	UbiA prenyltransferase family; Region: UbiA; pfam01040
449447008419	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
449447008420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447008421	S-adenosylmethionine binding site [chemical binding]; other site
449447008422	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
449447008423	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
449447008424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008425	ATP binding site [chemical binding]; other site
449447008426	Mg2+ binding site [ion binding]; other site
449447008427	G-X-G motif; other site
449447008428	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
449447008429	Response regulator receiver domain; Region: Response_reg; pfam00072
449447008430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008431	active site
449447008432	phosphorylation site [posttranslational modification]
449447008433	intermolecular recognition site; other site
449447008434	dimerization interface [polypeptide binding]; other site
449447008435	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447008436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008437	active site
449447008438	phosphorylation site [posttranslational modification]
449447008439	intermolecular recognition site; other site
449447008440	dimerization interface [polypeptide binding]; other site
449447008441	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447008442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447008443	S-adenosylmethionine binding site [chemical binding]; other site
449447008444	excinuclease ABC subunit B; Provisional; Region: PRK05298
449447008445	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447008446	ATP binding site [chemical binding]; other site
449447008447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447008448	nucleotide binding region [chemical binding]; other site
449447008449	ATP-binding site [chemical binding]; other site
449447008450	Ultra-violet resistance protein B; Region: UvrB; pfam12344
449447008451	UvrB/uvrC motif; Region: UVR; pfam02151
449447008452	hypothetical protein; Provisional; Region: PRK02509
449447008453	Uncharacterized conserved protein [Function unknown]; Region: COG1615
449447008454	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
449447008455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
449447008456	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
449447008457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447008458	dimer interface [polypeptide binding]; other site
449447008459	conserved gate region; other site
449447008460	putative PBP binding loops; other site
449447008461	ABC-ATPase subunit interface; other site
449447008462	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
449447008463	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
449447008464	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
449447008465	TPP-binding site [chemical binding]; other site
449447008466	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
449447008467	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
449447008468	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
449447008469	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
449447008470	SLBB domain; Region: SLBB; pfam10531
449447008471	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447008472	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447008473	active site
449447008474	catalytic tetrad [active]
449447008475	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
449447008476	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
449447008477	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
449447008478	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447008479	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447008480	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
449447008481	Chain length determinant protein; Region: Wzz; pfam02706
449447008482	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
449447008483	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
449447008484	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447008485	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447008486	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447008487	active site
449447008488	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
449447008489	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
449447008490	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447008491	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447008492	active site
449447008493	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
449447008494	O-Antigen ligase; Region: Wzy_C; pfam04932
449447008495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447008496	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
449447008497	putative ADP-binding pocket [chemical binding]; other site
449447008498	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
449447008499	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447008500	trimer interface [polypeptide binding]; other site
449447008501	active site
449447008502	substrate binding site [chemical binding]; other site
449447008503	CoA binding site [chemical binding]; other site
449447008504	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
449447008505	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
449447008506	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
449447008507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008508	Walker A/P-loop; other site
449447008509	ATP binding site [chemical binding]; other site
449447008510	Q-loop/lid; other site
449447008511	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
449447008512	ABC transporter; Region: ABC_tran_2; pfam12848
449447008513	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
449447008514	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447008515	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
449447008516	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
449447008517	Cl- selectivity filter; other site
449447008518	Cl- binding residues [ion binding]; other site
449447008519	pore gating glutamate residue; other site
449447008520	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008522	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008523	Probable transposase; Region: OrfB_IS605; pfam01385
449447008524	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
449447008525	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
449447008526	dimer interface [polypeptide binding]; other site
449447008527	motif 1; other site
449447008528	active site
449447008529	motif 2; other site
449447008530	motif 3; other site
449447008531	Homeodomain-like domain; Region: HTH_23; pfam13384
449447008532	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008533	Winged helix-turn helix; Region: HTH_33; pfam13592
449447008534	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008535	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447008536	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447008537	Calx-beta domain; Region: Calx-beta; cl02522
449447008538	Dihaem cytochrome c; Region: DHC; pfam09626
449447008539	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
449447008540	Helix-turn-helix domain; Region: HTH_25; pfam13413
449447008541	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
449447008542	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
449447008543	MPT binding site; other site
449447008544	trimer interface [polypeptide binding]; other site
449447008545	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
449447008546	UreF; Region: UreF; pfam01730
449447008547	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447008548	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447008549	putative metal binding site; other site
449447008550	putative acyl transferase; Provisional; Region: PRK10502
449447008551	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
449447008552	putative trimer interface [polypeptide binding]; other site
449447008553	putative active site [active]
449447008554	putative substrate binding site [chemical binding]; other site
449447008555	putative CoA binding site [chemical binding]; other site
449447008556	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447008557	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
449447008558	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447008559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008560	Probable transposase; Region: OrfB_IS605; pfam01385
449447008561	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008562	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447008563	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
449447008564	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
449447008565	Probable Catalytic site; other site
449447008566	metal-binding site
449447008567	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
449447008568	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
449447008569	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447008570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
449447008571	S-adenosylmethionine binding site [chemical binding]; other site
449447008572	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008573	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008574	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
449447008575	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
449447008576	Ligand binding site; other site
449447008577	Putative Catalytic site; other site
449447008578	DXD motif; other site
449447008579	Predicted membrane protein [Function unknown]; Region: COG2246
449447008580	GtrA-like protein; Region: GtrA; pfam04138
449447008581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008582	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008583	Probable transposase; Region: OrfB_IS605; pfam01385
449447008584	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008585	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
449447008586	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447008587	Ligand binding site; other site
449447008588	Putative Catalytic site; other site
449447008589	DXD motif; other site
449447008590	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
449447008591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008592	Probable transposase; Region: OrfB_IS605; pfam01385
449447008593	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008594	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008595	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447008596	DNA binding residues [nucleotide binding]
449447008597	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447008598	catalytic residues [active]
449447008599	catalytic nucleophile [active]
449447008600	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
449447008601	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
449447008602	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
449447008603	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
449447008604	active site
449447008605	SAM binding site [chemical binding]; other site
449447008606	homodimer interface [polypeptide binding]; other site
449447008607	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008608	putative active site [active]
449447008609	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008610	Uncharacterized conserved protein [Function unknown]; Region: COG2442
449447008611	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447008612	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447008613	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
449447008614	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
449447008615	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
449447008616	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
449447008617	Walker A/P-loop; other site
449447008618	ATP binding site [chemical binding]; other site
449447008619	Q-loop/lid; other site
449447008620	ABC transporter signature motif; other site
449447008621	Walker B; other site
449447008622	D-loop; other site
449447008623	H-loop/switch region; other site
449447008624	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
449447008625	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447008626	anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748
449447008627	TRAP binding interface [polypeptide binding]; other site
449447008628	Zn binding site [ion binding]; other site
449447008629	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
449447008630	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447008631	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447008632	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
449447008633	dimerization interface [polypeptide binding]; other site
449447008634	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447008635	dimer interface [polypeptide binding]; other site
449447008636	phosphorylation site [posttranslational modification]
449447008637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008638	ATP binding site [chemical binding]; other site
449447008639	Mg2+ binding site [ion binding]; other site
449447008640	G-X-G motif; other site
449447008641	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
449447008642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447008643	ATP binding site [chemical binding]; other site
449447008644	Mg2+ binding site [ion binding]; other site
449447008645	G-X-G motif; other site
449447008646	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
449447008647	ATP binding site [chemical binding]; other site
449447008648	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
449447008649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008650	Probable transposase; Region: OrfB_IS605; pfam01385
449447008651	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008652	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
449447008653	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
449447008654	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
449447008655	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
449447008656	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
449447008657	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008658	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447008659	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
449447008660	putative metal binding site [ion binding]; other site
449447008661	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
449447008662	active site
449447008663	catalytic triad [active]
449447008664	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447008665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008666	active site
449447008667	phosphorylation site [posttranslational modification]
449447008668	intermolecular recognition site; other site
449447008669	dimerization interface [polypeptide binding]; other site
449447008670	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
449447008671	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447008672	putative active site [active]
449447008673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
449447008674	FIST N domain; Region: FIST; pfam08495
449447008675	FIST C domain; Region: FIST_C; pfam10442
449447008676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008677	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008678	Probable transposase; Region: OrfB_IS605; pfam01385
449447008679	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008681	Probable transposase; Region: OrfB_IS605; pfam01385
449447008682	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008683	Uncharacterized conserved protein [Function unknown]; Region: COG4095
449447008684	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
449447008685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
449447008686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008687	Probable transposase; Region: OrfB_IS605; pfam01385
449447008688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008689	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008690	Probable transposase; Region: OrfB_IS605; pfam01385
449447008691	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008692	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447008693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447008694	Walker A/P-loop; other site
449447008695	ATP binding site [chemical binding]; other site
449447008696	Q-loop/lid; other site
449447008697	ABC transporter signature motif; other site
449447008698	Walker B; other site
449447008699	D-loop; other site
449447008700	H-loop/switch region; other site
449447008701	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
449447008702	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
449447008703	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
449447008704	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
449447008705	Walker A/P-loop; other site
449447008706	ATP binding site [chemical binding]; other site
449447008707	Q-loop/lid; other site
449447008708	ABC transporter signature motif; other site
449447008709	Walker B; other site
449447008710	D-loop; other site
449447008711	H-loop/switch region; other site
449447008712	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
449447008713	Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449
449447008714	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
449447008715	dimerization interface [polypeptide binding]; other site
449447008716	active site
449447008717	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
449447008718	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
449447008719	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
449447008720	TMP-binding site; other site
449447008721	ATP-binding site [chemical binding]; other site
449447008722	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
449447008723	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447008724	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447008725	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
449447008726	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
449447008727	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
449447008728	metal binding site [ion binding]; metal-binding site
449447008729	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
449447008730	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
449447008731	putative metal binding site; other site
449447008732	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008733	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447008734	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008735	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
449447008736	DNA binding residues [nucleotide binding]
449447008737	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447008738	catalytic residues [active]
449447008739	catalytic nucleophile [active]
449447008740	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
449447008741	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
449447008742	thiamine phosphate binding site [chemical binding]; other site
449447008743	active site
449447008744	pyrophosphate binding site [ion binding]; other site
449447008745	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
449447008746	thiS-thiF/thiG interaction site; other site
449447008747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008748	Probable transposase; Region: OrfB_IS605; pfam01385
449447008749	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008750	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
449447008751	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
449447008752	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
449447008753	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
449447008754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008755	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447008756	Probable transposase; Region: OrfB_IS605; pfam01385
449447008757	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008758	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447008759	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447008760	catalytic loop [active]
449447008761	iron binding site [ion binding]; other site
449447008762	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
449447008763	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
449447008764	domain interfaces; other site
449447008765	active site
449447008766	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447008767	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447008768	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447008769	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447008770	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447008771	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447008772	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447008773	active site
449447008774	ATP binding site [chemical binding]; other site
449447008775	substrate binding site [chemical binding]; other site
449447008776	activation loop (A-loop); other site
449447008777	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008778	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008779	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
449447008780	dimer interface [polypeptide binding]; other site
449447008781	motif 1; other site
449447008782	active site
449447008783	motif 2; other site
449447008784	motif 3; other site
449447008785	Lipoxygenase; Region: Lipoxygenase; pfam00305
449447008786	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
449447008787	elongation factor Tu; Region: tufA; CHL00071
449447008788	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
449447008789	G1 box; other site
449447008790	GEF interaction site [polypeptide binding]; other site
449447008791	GTP/Mg2+ binding site [chemical binding]; other site
449447008792	Switch I region; other site
449447008793	G2 box; other site
449447008794	G3 box; other site
449447008795	Switch II region; other site
449447008796	G4 box; other site
449447008797	G5 box; other site
449447008798	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
449447008799	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
449447008800	Antibiotic Binding Site [chemical binding]; other site
449447008801	elongation factor G; Reviewed; Region: PRK00007
449447008802	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
449447008803	G1 box; other site
449447008804	putative GEF interaction site [polypeptide binding]; other site
449447008805	GTP/Mg2+ binding site [chemical binding]; other site
449447008806	Switch I region; other site
449447008807	G2 box; other site
449447008808	G3 box; other site
449447008809	Switch II region; other site
449447008810	G4 box; other site
449447008811	G5 box; other site
449447008812	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
449447008813	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
449447008814	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
449447008815	30S ribosomal protein S7; Validated; Region: PRK05302
449447008816	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
449447008817	S17 interaction site [polypeptide binding]; other site
449447008818	S8 interaction site; other site
449447008819	16S rRNA interaction site [nucleotide binding]; other site
449447008820	streptomycin interaction site [chemical binding]; other site
449447008821	23S rRNA interaction site [nucleotide binding]; other site
449447008822	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
449447008823	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447008824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447008825	non-specific DNA binding site [nucleotide binding]; other site
449447008826	salt bridge; other site
449447008827	sequence-specific DNA binding site [nucleotide binding]; other site
449447008828	Domain of unknown function (DUF955); Region: DUF955; pfam06114
449447008829	NurA domain; Region: NurA; pfam09376
449447008830	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447008831	LabA_like proteins; Region: LabA; cd10911
449447008832	putative metal binding site [ion binding]; other site
449447008833	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
449447008834	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
449447008835	active site
449447008836	HIGH motif; other site
449447008837	KMSKS motif; other site
449447008838	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
449447008839	anticodon binding site; other site
449447008840	tRNA binding surface [nucleotide binding]; other site
449447008841	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447008842	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
449447008843	putative acyl-acceptor binding pocket; other site
449447008844	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008845	Homeodomain-like domain; Region: HTH_23; pfam13384
449447008846	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008847	Homeodomain-like domain; Region: HTH_32; pfam13565
449447008848	YcfA-like protein; Region: YcfA; pfam07927
449447008849	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447008850	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
449447008851	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447008852	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447008853	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447008854	P-loop; other site
449447008855	Magnesium ion binding site [ion binding]; other site
449447008856	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447008857	Magnesium ion binding site [ion binding]; other site
449447008858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447008859	GAF domain; Region: GAF; pfam01590
449447008860	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447008861	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447008862	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447008863	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447008864	tetramer interface [polypeptide binding]; other site
449447008865	dimer interface [polypeptide binding]; other site
449447008866	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
449447008867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447008868	active site
449447008869	phosphorylation site [posttranslational modification]
449447008870	intermolecular recognition site; other site
449447008871	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447008872	dimer interface [polypeptide binding]; other site
449447008873	[2Fe-2S] cluster binding site [ion binding]; other site
449447008874	Predicted membrane protein [Function unknown]; Region: COG4094
449447008875	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447008876	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447008877	catalytic residues [active]
449447008878	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447008879	metal ion-dependent adhesion site (MIDAS); other site
449447008880	Protein phosphatase 2C; Region: PP2C_2; pfam13672
449447008881	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447008882	active site
449447008883	NTP binding site [chemical binding]; other site
449447008884	metal binding triad [ion binding]; metal-binding site
449447008885	antibiotic binding site [chemical binding]; other site
449447008886	Uncharacterized conserved protein [Function unknown]; Region: COG2361
449447008887	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447008888	oligomeric interface; other site
449447008889	putative active site [active]
449447008890	homodimer interface [polypeptide binding]; other site
449447008891	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
449447008892	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
449447008893	active site
449447008894	ATP binding site [chemical binding]; other site
449447008895	substrate binding site [chemical binding]; other site
449447008896	activation loop (A-loop); other site
449447008897	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008898	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008899	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008900	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008901	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447008902	Haemolysin XhlA; Region: XhlA; pfam10779
449447008903	Homeodomain-like domain; Region: HTH_23; pfam13384
449447008904	Winged helix-turn helix; Region: HTH_29; pfam13551
449447008905	Homeodomain-like domain; Region: HTH_32; pfam13565
449447008906	Winged helix-turn helix; Region: HTH_33; pfam13592
449447008907	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447008908	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447008909	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447008910	dimer interface [polypeptide binding]; other site
449447008911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447008912	catalytic residue [active]
449447008913	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
449447008914	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008915	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008916	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447008917	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447008918	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447008919	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447008920	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447008921	MoxR-like ATPases [General function prediction only]; Region: COG0714
449447008922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447008923	Walker A motif; other site
449447008924	ATP binding site [chemical binding]; other site
449447008925	Walker B motif; other site
449447008926	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447008927	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
449447008928	putative di-iron ligands [ion binding]; other site
449447008929	Probable transposase; Region: OrfB_IS605; pfam01385
449447008930	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008931	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447008932	Probable transposase; Region: OrfB_IS605; pfam01385
449447008933	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447008934	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
449447008935	catalytic residues [active]
449447008936	catalytic nucleophile [active]
449447008937	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
449447008938	PhoH-like protein; Region: PhoH; pfam02562
449447008939	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
449447008940	23S rRNA binding site [nucleotide binding]; other site
449447008941	L21 binding site [polypeptide binding]; other site
449447008942	L13 binding site [polypeptide binding]; other site
449447008943	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
449447008944	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
449447008945	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
449447008946	active site
449447008947	dimer interface [polypeptide binding]; other site
449447008948	catalytic residue [active]
449447008949	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
449447008950	Ca2+ binding site [ion binding]; other site
449447008951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008952	Probable transposase; Region: OrfB_IS605; pfam01385
449447008953	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
449447008954	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
449447008955	CpeS-like protein; Region: CpeS; pfam09367
449447008956	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
449447008957	ATP-NAD kinase; Region: NAD_kinase; pfam01513
449447008958	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
449447008959	diiron center [ion binding]; other site
449447008960	putative radical transfer pathway; other site
449447008961	dimer interface [polypeptide binding]; other site
449447008962	tyrosyl radical; other site
449447008963	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
449447008964	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008965	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008966	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008967	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008968	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447008969	ATP cone domain; Region: ATP-cone; pfam03477
449447008970	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
449447008971	Class I ribonucleotide reductase; Region: RNR_I; cd01679
449447008972	active site
449447008973	dimer interface [polypeptide binding]; other site
449447008974	catalytic residues [active]
449447008975	effector binding site; other site
449447008976	R2 peptide binding site; other site
449447008977	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
449447008978	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447008979	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447008980	Homeodomain-like domain; Region: HTH_32; pfam13565
449447008981	Integrase core domain; Region: rve; pfam00665
449447008982	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
449447008983	Part of AAA domain; Region: AAA_19; pfam13245
449447008984	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
449447008985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447008986	Coenzyme A binding pocket [chemical binding]; other site
449447008987	Family of unknown function (DUF490); Region: DUF490; pfam04357
449447008988	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
449447008989	S-layer homology domain; Region: SLH; pfam00395
449447008990	S-layer homology domain; Region: SLH; pfam00395
449447008991	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447008992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447008993	Probable transposase; Region: OrfB_IS605; pfam01385
449447008994	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447008995	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
449447008996	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
449447008997	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
449447008998	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
449447008999	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
449447009000	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
449447009001	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009002	putative active site [active]
449447009003	Phosphoglycerate kinase; Region: PGK; pfam00162
449447009004	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
449447009005	substrate binding site [chemical binding]; other site
449447009006	hinge regions; other site
449447009007	ADP binding site [chemical binding]; other site
449447009008	catalytic site [active]
449447009009	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
449447009010	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
449447009011	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447009012	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447009013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447009014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009015	dimer interface [polypeptide binding]; other site
449447009016	phosphorylation site [posttranslational modification]
449447009017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009018	ATP binding site [chemical binding]; other site
449447009019	Mg2+ binding site [ion binding]; other site
449447009020	G-X-G motif; other site
449447009021	Response regulator receiver domain; Region: Response_reg; pfam00072
449447009022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447009023	active site
449447009024	phosphorylation site [posttranslational modification]
449447009025	intermolecular recognition site; other site
449447009026	dimerization interface [polypeptide binding]; other site
449447009027	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
449447009028	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447009029	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447009030	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009031	Walker A/P-loop; other site
449447009032	ATP binding site [chemical binding]; other site
449447009033	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
449447009034	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447009035	Predicted ATPase [General function prediction only]; Region: COG4637
449447009036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009037	Walker A/P-loop; other site
449447009038	ATP binding site [chemical binding]; other site
449447009039	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
449447009040	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
449447009041	23S rRNA interface [nucleotide binding]; other site
449447009042	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
449447009043	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
449447009044	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
449447009045	ATP cone domain; Region: ATP-cone; pfam03477
449447009046	30S ribosomal protein S1; Reviewed; Region: PRK07400
449447009047	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
449447009048	RNA binding site [nucleotide binding]; other site
449447009049	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
449447009050	RNA binding site [nucleotide binding]; other site
449447009051	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
449447009052	RNA binding site [nucleotide binding]; other site
449447009053	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447009054	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
449447009055	phosphopeptide binding site; other site
449447009056	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
449447009057	cyclase homology domain; Region: CHD; cd07302
449447009058	nucleotidyl binding site; other site
449447009059	metal binding site [ion binding]; metal-binding site
449447009060	dimer interface [polypeptide binding]; other site
449447009061	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
449447009062	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
449447009063	hypothetical protein; Provisional; Region: PRK10621
449447009064	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
449447009065	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
449447009066	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
449447009067	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
449447009068	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
449447009069	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447009070	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
449447009071	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447009072	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
449447009073	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009075	binding surface
449447009076	TPR motif; other site
449447009077	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009078	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009079	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447009080	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009082	binding surface
449447009083	TPR motif; other site
449447009084	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009085	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447009086	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009087	Homeodomain-like domain; Region: HTH_32; pfam13565
449447009088	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009091	binding surface
449447009092	TPR motif; other site
449447009093	YcfA-like protein; Region: YcfA; pfam07927
449447009094	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447009095	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447009096	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447009097	YcfA-like protein; Region: YcfA; pfam07927
449447009098	prolyl-tRNA synthetase; Provisional; Region: PRK09194
449447009099	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
449447009100	dimer interface [polypeptide binding]; other site
449447009101	motif 1; other site
449447009102	active site
449447009103	motif 2; other site
449447009104	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
449447009105	putative deacylase active site [active]
449447009106	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
449447009107	active site
449447009108	motif 3; other site
449447009109	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
449447009110	anticodon binding site; other site
449447009111	Homeodomain-like domain; Region: HTH_23; cl17451
449447009112	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009113	Homeodomain-like domain; Region: HTH_32; pfam13565
449447009114	DNA methylase; Region: N6_N4_Mtase; cl17433
449447009115	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
449447009116	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
449447009117	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
449447009118	active site
449447009119	substrate binding site [chemical binding]; other site
449447009120	metal binding site [ion binding]; metal-binding site
449447009121	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
449447009122	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447009123	Cysteine-rich domain; Region: CCG; pfam02754
449447009124	Cysteine-rich domain; Region: CCG; pfam02754
449447009125	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
449447009126	FAD binding domain; Region: FAD_binding_4; pfam01565
449447009127	aspartate aminotransferase; Provisional; Region: PRK05942
449447009128	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447009129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447009130	homodimer interface [polypeptide binding]; other site
449447009131	catalytic residue [active]
449447009132	hypothetical protein; Reviewed; Region: PRK00024
449447009133	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
449447009134	MPN+ (JAMM) motif; other site
449447009135	Zinc-binding site [ion binding]; other site
449447009136	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
449447009137	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
449447009138	dimerization interface [polypeptide binding]; other site
449447009139	putative ATP binding site [chemical binding]; other site
449447009140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009141	alpha-glucosidase; Provisional; Region: PRK10137
449447009142	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
449447009143	FO synthase subunit 2; Reviewed; Region: PRK07360
449447009144	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447009145	FeS/SAM binding site; other site
449447009146	Thf1-like protein; Reviewed; Region: PRK13266
449447009147	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
449447009148	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
449447009149	SmpB-tmRNA interface; other site
449447009150	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
449447009151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009152	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447009154	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009155	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
449447009156	DnaJ domain; Region: DnaJ; pfam00226
449447009157	HSP70 interaction site [polypeptide binding]; other site
449447009158	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447009159	Probable transposase; Region: OrfB_IS605; pfam01385
449447009160	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009161	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009162	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
449447009163	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
449447009164	tetramer interface [polypeptide binding]; other site
449447009165	TPP-binding site [chemical binding]; other site
449447009166	heterodimer interface [polypeptide binding]; other site
449447009167	phosphorylation loop region [posttranslational modification]
449447009168	Probable transposase; Region: OrfB_IS605; pfam01385
449447009169	Probable transposase; Region: OrfB_IS605; pfam01385
449447009170	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009171	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447009172	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
449447009173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009174	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009175	Probable transposase; Region: OrfB_IS605; pfam01385
449447009176	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447009177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447009178	active site
449447009179	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447009180	phosphorylation site [posttranslational modification]
449447009181	intermolecular recognition site; other site
449447009182	dimerization interface [polypeptide binding]; other site
449447009183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009184	dimer interface [polypeptide binding]; other site
449447009185	phosphorylation site [posttranslational modification]
449447009186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009187	ATP binding site [chemical binding]; other site
449447009188	Mg2+ binding site [ion binding]; other site
449447009189	G-X-G motif; other site
449447009190	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447009191	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447009192	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447009193	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447009194	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
449447009195	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447009196	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447009197	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447009198	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447009199	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
449447009200	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
449447009201	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
449447009202	active site
449447009203	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447009204	ABC1 family; Region: ABC1; cl17513
449447009205	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447009206	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
449447009207	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
449447009208	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009210	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009211	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009212	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
449447009213	hypothetical protein; Provisional; Region: PRK11479
449447009214	XisH protein; Region: XisH; pfam08814
449447009215	XisI protein; Region: XisI; pfam08869
449447009216	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
449447009217	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
449447009218	active site
449447009219	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
449447009220	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
449447009221	dimer interface [polypeptide binding]; other site
449447009222	active site
449447009223	DNA primase; Validated; Region: dnaG; PRK05667
449447009224	CHC2 zinc finger; Region: zf-CHC2; pfam01807
449447009225	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
449447009226	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
449447009227	active site
449447009228	metal binding site [ion binding]; metal-binding site
449447009229	interdomain interaction site; other site
449447009230	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
449447009231	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447009232	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
449447009233	active site
449447009234	Substrate binding site; other site
449447009235	Mg++ binding site; other site
449447009236	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447009237	putative trimer interface [polypeptide binding]; other site
449447009238	putative CoA binding site [chemical binding]; other site
449447009239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009240	Probable transposase; Region: OrfB_IS605; pfam01385
449447009241	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009242	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
449447009243	Predicted transcriptional regulator [Transcription]; Region: COG3682
449447009244	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
449447009245	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447009246	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447009247	catalytic triad [active]
449447009248	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
449447009249	rRNA interaction site [nucleotide binding]; other site
449447009250	S8 interaction site; other site
449447009251	putative laminin-1 binding site; other site
449447009252	elongation factor Ts; Reviewed; Region: tsf; PRK12332
449447009253	UBA/TS-N domain; Region: UBA; pfam00627
449447009254	Elongation factor TS; Region: EF_TS; pfam00889
449447009255	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
449447009256	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
449447009257	Active site cavity [active]
449447009258	catalytic acid [active]
449447009259	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447009260	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447009261	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
449447009262	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
449447009263	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
449447009264	active site
449447009265	ribulose/triose binding site [chemical binding]; other site
449447009266	phosphate binding site [ion binding]; other site
449447009267	substrate (anthranilate) binding pocket [chemical binding]; other site
449447009268	product (indole) binding pocket [chemical binding]; other site
449447009269	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
449447009270	homodimer interface [polypeptide binding]; other site
449447009271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447009272	catalytic residue [active]
449447009273	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
449447009274	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
449447009275	Peptidase family M23; Region: Peptidase_M23; pfam01551
449447009276	homoserine dehydrogenase; Provisional; Region: PRK06349
449447009277	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
449447009278	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
449447009279	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
449447009280	Predicted integral membrane protein [Function unknown]; Region: COG5542
449447009281	O-methyltransferase; Region: Methyltransf_2; pfam00891
449447009282	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
449447009283	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009284	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447009285	active site
449447009286	MoxR-like ATPases [General function prediction only]; Region: COG0714
449447009287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447009288	Walker A motif; other site
449447009289	ATP binding site [chemical binding]; other site
449447009290	Walker B motif; other site
449447009291	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447009292	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447009293	DNA-binding interface [nucleotide binding]; DNA binding site
449447009294	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447009296	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447009297	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447009298	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
449447009299	alpha-gamma subunit interface [polypeptide binding]; other site
449447009300	beta-gamma subunit interface [polypeptide binding]; other site
449447009301	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
449447009302	gamma-beta subunit interface [polypeptide binding]; other site
449447009303	alpha-beta subunit interface [polypeptide binding]; other site
449447009304	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
449447009305	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
449447009306	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447009307	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447009308	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447009309	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447009310	DNA binding residues [nucleotide binding]
449447009311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009312	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009313	Probable transposase; Region: OrfB_IS605; pfam01385
449447009314	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009315	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447009316	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447009317	catalytic loop [active]
449447009318	iron binding site [ion binding]; other site
449447009319	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
449447009320	Flavoprotein; Region: Flavoprotein; pfam02441
449447009321	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
449447009322	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
449447009323	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009324	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447009325	NAD(P) binding site [chemical binding]; other site
449447009326	active site
449447009327	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447009328	YcfA-like protein; Region: YcfA; pfam07927
449447009329	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
449447009330	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447009331	putative active site [active]
449447009332	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447009333	AAA ATPase domain; Region: AAA_16; pfam13191
449447009334	Tetratricopeptide repeat; Region: TPR_10; cl17452
449447009335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009336	TPR motif; other site
449447009337	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009338	binding surface
449447009339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009340	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447009341	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447009342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447009343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009344	TPR motif; other site
449447009345	binding surface
449447009346	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009348	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009349	DDE superfamily endonuclease; Region: DDE_5; pfam13546
449447009350	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009351	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447009352	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009353	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009354	Homeodomain-like domain; Region: HTH_23; pfam13384
449447009355	Homeodomain-like domain; Region: HTH_32; pfam13565
449447009356	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447009358	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009359	Homeodomain-like domain; Region: HTH_23; pfam13384
449447009360	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009361	Homeodomain-like domain; Region: HTH_32; pfam13565
449447009362	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009363	Homeodomain-like domain; Region: HTH_23; pfam13384
449447009364	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009365	Homeodomain-like domain; Region: HTH_32; pfam13565
449447009366	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447009367	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447009368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009369	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009370	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447009371	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
449447009372	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
449447009373	HIGH motif; other site
449447009374	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447009375	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
449447009376	active site
449447009377	KMSKS motif; other site
449447009378	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
449447009379	tRNA binding surface [nucleotide binding]; other site
449447009380	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
449447009381	BON domain; Region: BON; cl02771
449447009382	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
449447009383	Cysteine-rich domain; Region: CCG; pfam02754
449447009384	Cysteine-rich domain; Region: CCG; pfam02754
449447009385	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447009386	anti sigma factor interaction site; other site
449447009387	regulatory phosphorylation site [posttranslational modification]; other site
449447009388	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447009389	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447009390	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447009391	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447009392	Protein of unknown function (DUF790); Region: DUF790; pfam05626
449447009393	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
449447009394	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
449447009395	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
449447009396	putative dimer interface [polypeptide binding]; other site
449447009397	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447009398	Phosphate acyltransferases; Region: PlsC; smart00563
449447009399	putative acyl-acceptor binding pocket; other site
449447009400	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009401	putative active site [active]
449447009402	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
449447009403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009404	Probable transposase; Region: OrfB_IS605; pfam01385
449447009405	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009406	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
449447009407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447009408	Walker A motif; other site
449447009409	ATP binding site [chemical binding]; other site
449447009410	Walker B motif; other site
449447009411	arginine finger; other site
449447009412	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
449447009413	metal ion-dependent adhesion site (MIDAS); other site
449447009414	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
449447009415	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
449447009416	substrate binding site; other site
449447009417	dimer interface; other site
449447009418	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
449447009419	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
449447009420	active site
449447009421	substrate binding site [chemical binding]; other site
449447009422	trimer interface [polypeptide binding]; other site
449447009423	CoA binding site [chemical binding]; other site
449447009424	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447009425	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447009426	active site
449447009427	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
449447009428	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
449447009429	substrate binding site [chemical binding]; other site
449447009430	oxyanion hole (OAH) forming residues; other site
449447009431	trimer interface [polypeptide binding]; other site
449447009432	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
449447009433	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
449447009434	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
449447009435	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
449447009436	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447009437	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447009438	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447009439	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
449447009440	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
449447009441	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
449447009442	putative catalytic site [active]
449447009443	putative metal binding site [ion binding]; other site
449447009444	putative phosphate binding site [ion binding]; other site
449447009445	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
449447009446	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447009447	active site
449447009448	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
449447009449	Amidase; Region: Amidase; pfam01425
449447009450	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
449447009451	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
449447009452	Walker A/P-loop; other site
449447009453	ATP binding site [chemical binding]; other site
449447009454	Q-loop/lid; other site
449447009455	ABC transporter signature motif; other site
449447009456	Walker B; other site
449447009457	D-loop; other site
449447009458	H-loop/switch region; other site
449447009459	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
449447009460	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
449447009461	Walker A/P-loop; other site
449447009462	ATP binding site [chemical binding]; other site
449447009463	Q-loop/lid; other site
449447009464	ABC transporter signature motif; other site
449447009465	Walker B; other site
449447009466	D-loop; other site
449447009467	H-loop/switch region; other site
449447009468	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447009469	S-adenosylmethionine synthetase; Validated; Region: PRK05250
449447009470	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
449447009471	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
449447009472	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
449447009473	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
449447009474	Part of AAA domain; Region: AAA_19; pfam13245
449447009475	Family description; Region: UvrD_C_2; pfam13538
449447009476	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
449447009477	FOG: CBS domain [General function prediction only]; Region: COG0517
449447009478	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
449447009479	FOG: CBS domain [General function prediction only]; Region: COG0517
449447009480	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
449447009481	Recombinase; Region: Recombinase; pfam07508
449447009482	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447009483	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447009484	catalytic residues [active]
449447009485	FOG: CBS domain [General function prediction only]; Region: COG0517
449447009486	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
449447009487	CP12 domain; Region: CP12; pfam02672
449447009488	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
449447009489	oligomerisation interface [polypeptide binding]; other site
449447009490	mobile loop; other site
449447009491	roof hairpin; other site
449447009492	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
449447009493	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
449447009494	ring oligomerisation interface [polypeptide binding]; other site
449447009495	ATP/Mg binding site [chemical binding]; other site
449447009496	stacking interactions; other site
449447009497	hinge regions; other site
449447009498	Transposase domain (DUF772); Region: DUF772; pfam05598
449447009499	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447009500	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009501	Tetratricopeptide repeat; Region: TPR_10; pfam13374
449447009502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009503	TPR motif; other site
449447009504	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009505	binding surface
449447009506	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009508	binding surface
449447009509	TPR motif; other site
449447009510	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009512	binding surface
449447009513	TPR motif; other site
449447009514	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009515	YcfA-like protein; Region: YcfA; pfam07927
449447009516	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447009517	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
449447009518	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
449447009519	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
449447009520	Resolvase, N terminal domain; Region: Resolvase; smart00857
449447009521	Recombinase; Region: Recombinase; pfam07508
449447009522	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
449447009523	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
449447009524	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
449447009525	oligomer interface [polypeptide binding]; other site
449447009526	metal binding site [ion binding]; metal-binding site
449447009527	metal binding site [ion binding]; metal-binding site
449447009528	Cl binding site [ion binding]; other site
449447009529	aspartate ring; other site
449447009530	basic sphincter; other site
449447009531	putative hydrophobic gate; other site
449447009532	periplasmic entrance; other site
449447009533	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
449447009534	Phycobilisome protein; Region: Phycobilisome; cl08227
449447009535	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
449447009536	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
449447009537	glutathione reductase; Validated; Region: PRK06116
449447009538	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447009539	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447009540	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
449447009541	glycogen synthase; Provisional; Region: glgA; PRK00654
449447009542	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
449447009543	ADP-binding pocket [chemical binding]; other site
449447009544	homodimer interface [polypeptide binding]; other site
449447009545	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
449447009546	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447009547	catalytic residues [active]
449447009548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447009549	S-adenosylmethionine binding site [chemical binding]; other site
449447009550	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447009551	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
449447009552	active site
449447009553	metal binding site [ion binding]; metal-binding site
449447009554	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
449447009555	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
449447009556	Cupin domain; Region: Cupin_2; cl17218
449447009557	Transposase domain (DUF772); Region: DUF772; pfam05598
449447009558	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447009559	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
449447009560	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009561	NAD binding site [chemical binding]; other site
449447009562	homotetramer interface [polypeptide binding]; other site
449447009563	homodimer interface [polypeptide binding]; other site
449447009564	active site
449447009565	substrate binding site [chemical binding]; other site
449447009566	Predicted membrane protein [Function unknown]; Region: COG2246
449447009567	GtrA-like protein; Region: GtrA; pfam04138
449447009568	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447009569	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447009570	Ligand binding site; other site
449447009571	Putative Catalytic site; other site
449447009572	DXD motif; other site
449447009573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009574	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009575	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447009576	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
449447009577	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009578	NAD binding site [chemical binding]; other site
449447009579	homotetramer interface [polypeptide binding]; other site
449447009580	homodimer interface [polypeptide binding]; other site
449447009581	active site
449447009582	substrate binding site [chemical binding]; other site
449447009583	pantothenate kinase; Reviewed; Region: PRK13331
449447009584	phosphodiesterase YaeI; Provisional; Region: PRK11340
449447009585	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
449447009586	putative active site [active]
449447009587	putative metal binding site [ion binding]; other site
449447009588	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
449447009589	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447009590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447009591	homodimer interface [polypeptide binding]; other site
449447009592	catalytic residue [active]
449447009593	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
449447009594	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447009595	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
449447009596	putative NAD(P) binding site [chemical binding]; other site
449447009597	active site
449447009598	UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950
449447009599	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009600	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009601	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
449447009602	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
449447009603	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009604	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009605	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009606	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009607	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
449447009608	diiron binding motif [ion binding]; other site
449447009609	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
449447009610	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
449447009611	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
449447009612	Moco binding site; other site
449447009613	metal coordination site [ion binding]; other site
449447009614	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009616	TPR motif; other site
449447009617	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009618	binding surface
449447009619	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447009621	binding surface
449447009622	TPR motif; other site
449447009623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009624	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447009625	Tetratricopeptide repeat; Region: TPR_1; pfam00515
449447009626	AAA ATPase domain; Region: AAA_16; pfam13191
449447009627	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447009628	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009629	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447009630	BolA-like protein; Region: BolA; pfam01722
449447009631	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009632	putative active site [active]
449447009633	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447009634	putative active site [active]
449447009635	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
449447009636	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
449447009637	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
449447009638	homodimer interface [polypeptide binding]; other site
449447009639	NADP binding site [chemical binding]; other site
449447009640	substrate binding site [chemical binding]; other site
449447009641	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
449447009642	generic binding surface II; other site
449447009643	generic binding surface I; other site
449447009644	four helix bundle protein; Region: TIGR02436
449447009645	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
449447009646	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
449447009647	nudix motif; other site
449447009648	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
449447009649	C-terminal peptidase (prc); Region: prc; TIGR00225
449447009650	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
449447009651	protein binding site [polypeptide binding]; other site
449447009652	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
449447009653	Catalytic dyad [active]
449447009654	recombination protein RecR; Reviewed; Region: recR; PRK00076
449447009655	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
449447009656	RecR protein; Region: RecR; pfam02132
449447009657	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
449447009658	putative active site [active]
449447009659	putative metal-binding site [ion binding]; other site
449447009660	tetramer interface [polypeptide binding]; other site
449447009661	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
449447009662	arginine decarboxylase; Provisional; Region: PRK05354
449447009663	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
449447009664	dimer interface [polypeptide binding]; other site
449447009665	active site
449447009666	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447009667	catalytic residues [active]
449447009668	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
449447009669	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447009670	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
449447009671	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
449447009672	catalytic site [active]
449447009673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009674	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009675	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009676	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447009677	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009678	Exoribonuclease R [Transcription]; Region: VacB; COG0557
449447009679	RNB domain; Region: RNB; pfam00773
449447009680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009681	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009682	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447009683	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
449447009684	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447009685	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447009686	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447009687	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447009688	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
449447009689	dimer interface [polypeptide binding]; other site
449447009690	substrate binding site [chemical binding]; other site
449447009691	metal binding sites [ion binding]; metal-binding site
449447009692	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
449447009693	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
449447009694	putative active site cavity [active]
449447009695	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
449447009696	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
449447009697	[2Fe-2S] cluster binding site [ion binding]; other site
449447009698	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
449447009699	hydrophobic ligand binding site; other site
449447009700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009701	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009702	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
449447009703	AAA-like domain; Region: AAA_10; pfam12846
449447009704	NurA nuclease; Region: NurA; smart00933
449447009705	agmatinase; Region: agmatinase; TIGR01230
449447009706	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
449447009707	putative active site [active]
449447009708	Mn binding site [ion binding]; other site
449447009709	GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465
449447009710	active site
449447009711	GIY-YIG motif/motif A; other site
449447009712	catalytic site [active]
449447009713	metal binding site [ion binding]; metal-binding site
449447009714	DNA-sulfur modification-associated; Region: DndB; cl17621
449447009715	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447009716	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
449447009717	Protein of unknown function DUF86; Region: DUF86; cl01031
449447009718	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447009719	active site
449447009720	NTP binding site [chemical binding]; other site
449447009721	metal binding triad [ion binding]; metal-binding site
449447009722	antibiotic binding site [chemical binding]; other site
449447009723	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
449447009724	Predicted transcriptional regulator [Transcription]; Region: COG3636
449447009725	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
449447009726	active site
449447009727	SAM binding site [chemical binding]; other site
449447009728	homodimer interface [polypeptide binding]; other site
449447009729	Uncharacterized conserved protein [Function unknown]; Region: COG0432
449447009730	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
449447009731	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
449447009732	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
449447009733	PIN domain; Region: PIN; pfam01850
449447009734	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447009735	active site
449447009736	NTP binding site [chemical binding]; other site
449447009737	metal binding triad [ion binding]; metal-binding site
449447009738	antibiotic binding site [chemical binding]; other site
449447009739	Protein of unknown function DUF86; Region: DUF86; cl01031
449447009740	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
449447009741	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447009742	substrate binding pocket [chemical binding]; other site
449447009743	membrane-bound complex binding site; other site
449447009744	hinge residues; other site
449447009745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
449447009746	Transposase; Region: DEDD_Tnp_IS110; pfam01548
449447009747	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
449447009748	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
449447009749	Putative transcription activator [Transcription]; Region: TenA; COG0819
449447009750	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
449447009751	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
449447009752	threonine synthase; Validated; Region: PRK06381
449447009753	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
449447009754	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447009755	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447009756	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009757	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
449447009758	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
449447009759	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447009760	Dynamin family; Region: Dynamin_N; pfam00350
449447009761	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
449447009762	G3 box; other site
449447009763	Switch II region; other site
449447009764	G4 box; other site
449447009765	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447009766	Dynamin family; Region: Dynamin_N; pfam00350
449447009767	G1 box; other site
449447009768	GTP/Mg2+ binding site [chemical binding]; other site
449447009769	G2 box; other site
449447009770	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447009771	G3 box; other site
449447009772	Switch II region; other site
449447009773	G4 box; other site
449447009774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447009775	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447009776	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009777	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
449447009778	AAA domain; Region: AAA_21; pfam13304
449447009779	Transposase domain (DUF772); Region: DUF772; pfam05598
449447009780	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447009781	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009782	AAA domain; Region: AAA_21; pfam13304
449447009783	Walker A/P-loop; other site
449447009784	ATP binding site [chemical binding]; other site
449447009785	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447009786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009787	Walker A/P-loop; other site
449447009788	ATP binding site [chemical binding]; other site
449447009789	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447009790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009791	Walker A/P-loop; other site
449447009792	ATP binding site [chemical binding]; other site
449447009793	AAA domain; Region: AAA_21; pfam13304
449447009794	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447009795	ABC transporter signature motif; other site
449447009796	Walker B; other site
449447009797	D-loop; other site
449447009798	H-loop/switch region; other site
449447009799	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
449447009800	multimerization interface [polypeptide binding]; other site
449447009801	RbcX protein; Region: RcbX; pfam02341
449447009802	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
449447009803	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
449447009804	homodimer interface [polypeptide binding]; other site
449447009805	active site
449447009806	heterodimer interface [polypeptide binding]; other site
449447009807	catalytic residue [active]
449447009808	metal binding site [ion binding]; metal-binding site
449447009809	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
449447009810	putative trimer interface [polypeptide binding]; other site
449447009811	putative CoA binding site [chemical binding]; other site
449447009812	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
449447009813	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
449447009814	trimer interface [polypeptide binding]; other site
449447009815	active site
449447009816	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009817	putative multimerization interface [polypeptide binding]; other site
449447009818	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009819	putative multimerization interface [polypeptide binding]; other site
449447009820	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009821	putative multimerization interface [polypeptide binding]; other site
449447009822	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
449447009823	putative multimerization interface [polypeptide binding]; other site
449447009824	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
449447009825	Hexamer/Pentamer interface [polypeptide binding]; other site
449447009826	central pore; other site
449447009827	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447009828	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447009829	Hexamer interface [polypeptide binding]; other site
449447009830	Hexagonal pore residue; other site
449447009831	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447009832	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447009833	Hexamer interface [polypeptide binding]; other site
449447009834	Hexagonal pore residue; other site
449447009835	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
449447009836	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
449447009837	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447009838	FeS/SAM binding site; other site
449447009839	TRAM domain; Region: TRAM; pfam01938
449447009840	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
449447009841	AAA domain; Region: AAA_14; pfam13173
449447009842	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
449447009843	Switch II region; other site
449447009844	G4 box; other site
449447009845	Domain of unknown function (DUF697); Region: DUF697; pfam05128
449447009846	Homeodomain-like domain; Region: HTH_23; pfam13384
449447009847	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009848	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009849	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009850	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447009851	ribosomal protein L33; Region: rpl33; CHL00104
449447009852	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
449447009853	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
449447009855	PAS fold; Region: PAS_4; pfam08448
449447009856	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447009857	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447009858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
449447009859	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
449447009860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447009861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447009862	dimer interface [polypeptide binding]; other site
449447009863	phosphorylation site [posttranslational modification]
449447009864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009865	ATP binding site [chemical binding]; other site
449447009866	Mg2+ binding site [ion binding]; other site
449447009867	G-X-G motif; other site
449447009868	HEAT repeats; Region: HEAT_2; pfam13646
449447009869	HEAT repeats; Region: HEAT_2; pfam13646
449447009870	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
449447009871	aromatic acid decarboxylase; Validated; Region: PRK05920
449447009872	Flavoprotein; Region: Flavoprotein; pfam02441
449447009873	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
449447009874	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
449447009875	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
449447009876	putative valine binding site [chemical binding]; other site
449447009877	dimer interface [polypeptide binding]; other site
449447009878	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
449447009879	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
449447009880	phosphopeptide binding site; other site
449447009881	Transglycosylase; Region: Transgly; pfam00912
449447009882	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
449447009883	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
449447009884	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
449447009885	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
449447009886	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
449447009887	putative di-iron ligands [ion binding]; other site
449447009888	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
449447009889	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447009890	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447009891	CHAT domain; Region: CHAT; cl17868
449447009892	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447009893	binding surface
449447009894	TPR repeat; Region: TPR_11; pfam13414
449447009895	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447009896	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447009897	putative ligand binding site [chemical binding]; other site
449447009898	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447009899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447009900	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
449447009901	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
449447009902	putative ligand binding site [chemical binding]; other site
449447009903	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447009904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447009905	active site
449447009906	phosphorylation site [posttranslational modification]
449447009907	intermolecular recognition site; other site
449447009908	dimerization interface [polypeptide binding]; other site
449447009909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447009910	DNA binding site [nucleotide binding]
449447009911	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
449447009912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447009913	ATP binding site [chemical binding]; other site
449447009914	Mg2+ binding site [ion binding]; other site
449447009915	G-X-G motif; other site
449447009916	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
449447009917	anchoring element; other site
449447009918	dimer interface [polypeptide binding]; other site
449447009919	ATP binding site [chemical binding]; other site
449447009920	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
449447009921	active site
449447009922	putative metal-binding site [ion binding]; other site
449447009923	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
449447009924	Protein of unknown function (DUF497); Region: DUF497; pfam04365
449447009925	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447009926	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447009927	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447009928	catalytic residue [active]
449447009929	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
449447009930	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
449447009931	RNase_H superfamily; Region: RNase_H_2; pfam13482
449447009932	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
449447009933	intersubunit interface [polypeptide binding]; other site
449447009934	active site
449447009935	Zn2+ binding site [ion binding]; other site
449447009936	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
449447009937	Mrr N-terminal domain; Region: Mrr_N; pfam14338
449447009938	Restriction endonuclease; Region: Mrr_cat; pfam04471
449447009939	CpeS-like protein; Region: CpeS; pfam09367
449447009940	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447009941	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
449447009942	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
449447009943	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447009944	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447009945	Ligand Binding Site [chemical binding]; other site
449447009946	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447009947	Ligand Binding Site [chemical binding]; other site
449447009948	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009949	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447009950	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447009951	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447009952	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
449447009953	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447009954	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
449447009955	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
449447009956	Walker A/P-loop; other site
449447009957	ATP binding site [chemical binding]; other site
449447009958	Q-loop/lid; other site
449447009959	ABC transporter signature motif; other site
449447009960	Walker B; other site
449447009961	D-loop; other site
449447009962	H-loop/switch region; other site
449447009963	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
449447009964	ABC-2 type transporter; Region: ABC2_membrane; cl17235
449447009965	Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303
449447009966	inhibitor binding site; inhibition site
449447009967	catalytic motif [active]
449447009968	Catalytic residue [active]
449447009969	Active site flap [active]
449447009970	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447009971	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447009972	YcfA-like protein; Region: YcfA; cl00752
449447009973	Winged helix-turn helix; Region: HTH_29; pfam13551
449447009974	Homeodomain-like domain; Region: HTH_23; pfam13384
449447009975	Winged helix-turn helix; Region: HTH_33; pfam13592
449447009976	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447009977	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447009978	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009979	Probable transposase; Region: OrfB_IS605; pfam01385
449447009980	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009981	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
449447009982	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
449447009983	trmE is a tRNA modification GTPase; Region: trmE; cd04164
449447009984	G1 box; other site
449447009985	GTP/Mg2+ binding site [chemical binding]; other site
449447009986	Switch I region; other site
449447009987	G2 box; other site
449447009988	Switch II region; other site
449447009989	G3 box; other site
449447009990	G4 box; other site
449447009991	G5 box; other site
449447009992	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
449447009993	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
449447009994	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
449447009995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447009996	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447009997	Probable transposase; Region: OrfB_IS605; pfam01385
449447009998	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447009999	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447010000	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447010001	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447010002	putative active site [active]
449447010003	putative NTP binding site [chemical binding]; other site
449447010004	putative nucleic acid binding site [nucleotide binding]; other site
449447010005	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447010006	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447010007	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447010008	active site
449447010009	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
449447010010	alanine racemase; Reviewed; Region: alr; PRK00053
449447010011	active site
449447010012	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447010013	dimer interface [polypeptide binding]; other site
449447010014	substrate binding site [chemical binding]; other site
449447010015	catalytic residues [active]
449447010016	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
449447010017	Cytochrome P450; Region: p450; cl12078
449447010018	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
449447010019	ABC1 family; Region: ABC1; pfam03109
449447010020	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
449447010021	active site
449447010022	ATP binding site [chemical binding]; other site
449447010023	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
449447010024	TIGR02646 family protein; Region: TIGR02646
449447010025	AAA domain; Region: AAA_23; pfam13476
449447010026	AAA domain; Region: AAA_21; pfam13304
449447010027	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
449447010028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447010029	Walker A/P-loop; other site
449447010030	ATP binding site [chemical binding]; other site
449447010031	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
449447010032	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
449447010033	active site
449447010034	dinuclear metal binding site [ion binding]; other site
449447010035	dimerization interface [polypeptide binding]; other site
449447010036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
449447010037	Protein of unknown function, DUF482; Region: DUF482; pfam04339
449447010038	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
449447010039	RibD C-terminal domain; Region: RibD_C; cl17279
449447010040	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
449447010041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447010042	dimer interface [polypeptide binding]; other site
449447010043	phosphorylation site [posttranslational modification]
449447010044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447010045	ATP binding site [chemical binding]; other site
449447010046	Mg2+ binding site [ion binding]; other site
449447010047	G-X-G motif; other site
449447010048	prephenate dehydratase; Provisional; Region: PRK11898
449447010049	Prephenate dehydratase; Region: PDT; pfam00800
449447010050	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
449447010051	putative L-Phe binding site [chemical binding]; other site
449447010052	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
449447010053	active site
449447010054	catalytic site [active]
449447010055	substrate binding site [chemical binding]; other site
449447010056	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447010057	Ligand Binding Site [chemical binding]; other site
449447010058	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
449447010059	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
449447010060	Catalytic site [active]
449447010061	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
449447010062	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
449447010063	homodimer interface [polypeptide binding]; other site
449447010064	metal binding site [ion binding]; metal-binding site
449447010065	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
449447010066	homodimer interface [polypeptide binding]; other site
449447010067	active site
449447010068	putative chemical substrate binding site [chemical binding]; other site
449447010069	metal binding site [ion binding]; metal-binding site
449447010070	Cupin domain; Region: Cupin_2; cl17218
449447010071	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
449447010072	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
449447010073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010074	binding surface
449447010075	TPR motif; other site
449447010076	stage V sporulation protein AD; Validated; Region: PRK08304
449447010077	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
449447010078	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447010079	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447010080	active site
449447010081	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
449447010082	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
449447010083	active site
449447010084	substrate binding site [chemical binding]; other site
449447010085	metal binding site [ion binding]; metal-binding site
449447010086	RRXRR protein; Region: RRXRR; pfam14239
449447010087	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
449447010088	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447010089	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
449447010090	active site
449447010091	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
449447010092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447010093	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
449447010094	RNA polymerase sigma factor; Provisional; Region: PRK12518
449447010095	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010096	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010097	DNA binding residues [nucleotide binding]
449447010098	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
449447010099	dimer interface [polypeptide binding]; other site
449447010100	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
449447010101	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
449447010102	NAD binding site [chemical binding]; other site
449447010103	substrate binding site [chemical binding]; other site
449447010104	active site
449447010105	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
449447010106	putative active site [active]
449447010107	putative metal binding site [ion binding]; other site
449447010108	Haemolysin XhlA; Region: XhlA; pfam10779
449447010109	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
449447010110	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
449447010111	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
449447010112	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
449447010113	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
449447010114	putative catalytic cysteine [active]
449447010115	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
449447010116	putative active site [active]
449447010117	metal binding site [ion binding]; metal-binding site
449447010118	AAA domain; Region: AAA_21; pfam13304
449447010119	phycobillisome linker protein; Region: apcE; CHL00091
449447010120	Phycobilisome protein; Region: Phycobilisome; cl08227
449447010121	Phycobilisome protein; Region: Phycobilisome; cl08227
449447010122	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447010123	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447010124	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
449447010125	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
449447010126	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447010127	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447010128	ligand binding site [chemical binding]; other site
449447010129	flexible hinge region; other site
449447010130	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447010131	putative switch regulator; other site
449447010132	non-specific DNA interactions [nucleotide binding]; other site
449447010133	DNA binding site [nucleotide binding]
449447010134	sequence specific DNA binding site [nucleotide binding]; other site
449447010135	putative cAMP binding site [chemical binding]; other site
449447010136	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
449447010137	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
449447010138	GTPase RsgA; Reviewed; Region: PRK12289
449447010139	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
449447010140	RNA binding site [nucleotide binding]; other site
449447010141	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
449447010142	GTPase/Zn-binding domain interface [polypeptide binding]; other site
449447010143	GTP/Mg2+ binding site [chemical binding]; other site
449447010144	G4 box; other site
449447010145	G5 box; other site
449447010146	G1 box; other site
449447010147	Switch I region; other site
449447010148	G2 box; other site
449447010149	G3 box; other site
449447010150	Switch II region; other site
449447010151	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
449447010152	CPxP  motif; other site
449447010153	chaperone protein DnaJ; Provisional; Region: PRK14293
449447010154	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
449447010155	HSP70 interaction site [polypeptide binding]; other site
449447010156	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
449447010157	substrate binding site [polypeptide binding]; other site
449447010158	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
449447010159	Zn binding sites [ion binding]; other site
449447010160	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
449447010161	dimer interface [polypeptide binding]; other site
449447010162	molecular chaperone DnaK; Provisional; Region: PRK13411
449447010163	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
449447010164	nucleotide binding site [chemical binding]; other site
449447010165	NEF interaction site [polypeptide binding]; other site
449447010166	SBD interface [polypeptide binding]; other site
449447010167	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
449447010168	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
449447010169	putative NAD(P) binding site [chemical binding]; other site
449447010170	putative substrate binding site [chemical binding]; other site
449447010171	catalytic Zn binding site [ion binding]; other site
449447010172	structural Zn binding site [ion binding]; other site
449447010173	dimer interface [polypeptide binding]; other site
449447010174	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447010175	putative active site [active]
449447010176	Uncharacterized conserved protein [Function unknown]; Region: COG0062
449447010177	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
449447010178	putative substrate binding site [chemical binding]; other site
449447010179	putative ATP binding site [chemical binding]; other site
449447010180	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010181	aspartate kinase; Provisional; Region: PRK07431
449447010182	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
449447010183	putative catalytic residues [active]
449447010184	putative nucleotide binding site [chemical binding]; other site
449447010185	putative aspartate binding site [chemical binding]; other site
449447010186	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
449447010187	putative allosteric regulatory site; other site
449447010188	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
449447010189	putative allosteric regulatory residue; other site
449447010190	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
449447010191	putative allosteric regulatory site; other site
449447010192	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
449447010193	NB-ARC domain; Region: NB-ARC; pfam00931
449447010194	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447010195	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447010196	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
449447010197	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447010198	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
449447010199	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
449447010200	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447010201	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
449447010202	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447010203	cofactor binding site; other site
449447010204	DNA binding site [nucleotide binding]
449447010205	substrate interaction site [chemical binding]; other site
449447010206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010207	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010208	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010209	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010210	M6 family metalloprotease domain; Region: M6dom_TIGR03296
449447010211	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447010212	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447010213	DNA binding residues [nucleotide binding]
449447010214	dimerization interface [polypeptide binding]; other site
449447010215	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447010216	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447010217	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447010218	cofactor binding site; other site
449447010219	DNA binding site [nucleotide binding]
449447010220	substrate interaction site [chemical binding]; other site
449447010221	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447010222	HflC protein; Region: hflC; TIGR01932
449447010223	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447010224	EVE domain; Region: EVE; cl00728
449447010225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447010226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447010227	dimer interface [polypeptide binding]; other site
449447010228	phosphorylation site [posttranslational modification]
449447010229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447010230	ATP binding site [chemical binding]; other site
449447010231	Mg2+ binding site [ion binding]; other site
449447010232	G-X-G motif; other site
449447010233	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
449447010234	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010235	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010236	Probable transposase; Region: OrfB_IS605; pfam01385
449447010237	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010238	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447010239	FeS/SAM binding site; other site
449447010240	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010241	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010242	Probable transposase; Region: OrfB_IS605; pfam01385
449447010243	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010244	geranylgeranyl reductase; Region: ChlP; TIGR02028
449447010245	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447010246	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
449447010247	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
449447010248	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
449447010249	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
449447010250	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447010251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447010252	NAD(P) binding site [chemical binding]; other site
449447010253	active site
449447010254	putative acyltransferase; Provisional; Region: PRK05790
449447010255	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
449447010256	dimer interface [polypeptide binding]; other site
449447010257	active site
449447010258	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
449447010259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447010260	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
449447010261	ATP synthase I chain; Region: ATP_synt_I; pfam03899
449447010262	ATP synthase CF0 A subunit; Region: atpI; CHL00046
449447010263	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
449447010264	ATP synthase CF0 C subunit; Region: atpH; CHL00061
449447010265	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
449447010266	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
449447010267	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
449447010268	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
449447010269	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
449447010270	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
449447010271	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
449447010272	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
449447010273	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
449447010274	beta subunit interaction interface [polypeptide binding]; other site
449447010275	Walker A motif; other site
449447010276	ATP binding site [chemical binding]; other site
449447010277	Walker B motif; other site
449447010278	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
449447010279	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
449447010280	core domain interface [polypeptide binding]; other site
449447010281	delta subunit interface [polypeptide binding]; other site
449447010282	epsilon subunit interface [polypeptide binding]; other site
449447010283	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
449447010284	Calx-beta domain; Region: Calx-beta; cl02522
449447010285	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
449447010286	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
449447010287	Calx-beta domain; Region: Calx-beta; pfam03160
449447010288	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
449447010289	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
449447010290	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
449447010291	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
449447010292	homotetramer interface [polypeptide binding]; other site
449447010293	ligand binding site [chemical binding]; other site
449447010294	catalytic site [active]
449447010295	NAD binding site [chemical binding]; other site
449447010296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447010297	non-specific DNA binding site [nucleotide binding]; other site
449447010298	salt bridge; other site
449447010299	sequence-specific DNA binding site [nucleotide binding]; other site
449447010300	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
449447010301	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
449447010302	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
449447010303	Lumazine binding domain; Region: Lum_binding; pfam00677
449447010304	Lumazine binding domain; Region: Lum_binding; pfam00677
449447010305	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
449447010306	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
449447010307	putative catalytic cysteine [active]
449447010308	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
449447010309	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
449447010310	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
449447010311	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
449447010312	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
449447010313	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447010314	Di-iron ligands [ion binding]; other site
449447010315	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
449447010316	Aluminium resistance protein; Region: Alum_res; pfam06838
449447010317	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
449447010318	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447010319	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
449447010320	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
449447010321	metal ion-dependent adhesion site (MIDAS); other site
449447010322	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
449447010323	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
449447010324	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447010325	Coenzyme A binding pocket [chemical binding]; other site
449447010326	acyl-CoA synthetase; Validated; Region: PRK07788
449447010327	MAPEG family; Region: MAPEG; cl09190
449447010328	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
449447010329	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
449447010330	active site
449447010331	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
449447010332	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447010333	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
449447010334	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
449447010335	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
449447010336	ATP-grasp domain; Region: ATP-grasp_4; cl17255
449447010337	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
449447010338	IMP binding site; other site
449447010339	dimer interface [polypeptide binding]; other site
449447010340	interdomain contacts; other site
449447010341	partial ornithine binding site; other site
449447010342	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
449447010343	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
449447010344	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
449447010345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447010346	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
449447010347	epoxyqueuosine reductase; Region: TIGR00276
449447010348	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
449447010349	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447010350	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447010351	motif II; other site
449447010352	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
449447010353	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
449447010354	Protein of unknown function, DUF258; Region: DUF258; pfam03193
449447010355	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447010356	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447010357	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447010358	structural tetrad; other site
449447010359	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447010360	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
449447010361	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447010362	FeS/SAM binding site; other site
449447010363	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
449447010364	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
449447010365	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
449447010366	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
449447010367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447010368	Walker A motif; other site
449447010369	ATP binding site [chemical binding]; other site
449447010370	Walker B motif; other site
449447010371	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
449447010372	RxxxH motif; other site
449447010373	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
449447010374	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
449447010375	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
449447010376	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447010377	non-specific DNA binding site [nucleotide binding]; other site
449447010378	salt bridge; other site
449447010379	sequence-specific DNA binding site [nucleotide binding]; other site
449447010380	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
449447010381	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
449447010382	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
449447010383	Probable transposase; Region: OrfB_IS605; pfam01385
449447010384	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010385	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447010386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010387	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
449447010388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447010389	S-adenosylmethionine binding site [chemical binding]; other site
449447010390	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
449447010391	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
449447010392	ligand binding site [chemical binding]; other site
449447010393	NAD binding site [chemical binding]; other site
449447010394	dimerization interface [polypeptide binding]; other site
449447010395	catalytic site [active]
449447010396	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
449447010397	putative L-serine binding site [chemical binding]; other site
449447010398	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
449447010399	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
449447010400	PYR/PP interface [polypeptide binding]; other site
449447010401	dimer interface [polypeptide binding]; other site
449447010402	TPP binding site [chemical binding]; other site
449447010403	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
449447010404	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
449447010405	TPP-binding site [chemical binding]; other site
449447010406	dimer interface [polypeptide binding]; other site
449447010407	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447010408	AAA domain; Region: AAA_26; pfam13500
449447010409	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
449447010410	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
449447010411	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447010412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010413	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010414	Probable transposase; Region: OrfB_IS605; pfam01385
449447010415	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010416	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
449447010417	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447010418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447010419	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
449447010420	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
449447010421	Predicted membrane protein [Function unknown]; Region: COG3431
449447010422	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447010423	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447010424	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
449447010425	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
449447010426	putative active site [active]
449447010427	putative catalytic triad [active]
449447010428	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
449447010429	Calx-beta domain; Region: Calx-beta; cl02522
449447010430	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
449447010431	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447010432	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010433	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447010434	PIN domain; Region: PIN; pfam01850
449447010435	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
449447010436	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
449447010437	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
449447010438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010439	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010440	Probable transposase; Region: OrfB_IS605; pfam01385
449447010441	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010442	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447010443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010444	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010445	Probable transposase; Region: OrfB_IS605; pfam01385
449447010446	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010447	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
449447010448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447010449	motif II; other site
449447010450	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
449447010451	nitrilase; Region: PLN02798
449447010452	putative active site [active]
449447010453	catalytic triad [active]
449447010454	dimer interface [polypeptide binding]; other site
449447010455	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447010456	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447010457	DNA-binding interface [nucleotide binding]; DNA binding site
449447010458	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447010459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010460	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
449447010461	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
449447010462	active site
449447010463	NTP binding site [chemical binding]; other site
449447010464	metal binding triad [ion binding]; metal-binding site
449447010465	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
449447010466	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
449447010467	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
449447010468	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447010469	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447010470	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
449447010471	OstA-like protein; Region: OstA; cl00844
449447010472	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
449447010473	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
449447010474	Predicted methyltransferases [General function prediction only]; Region: COG0313
449447010475	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
449447010476	putative SAM binding site [chemical binding]; other site
449447010477	putative homodimer interface [polypeptide binding]; other site
449447010478	Predicted permeases [General function prediction only]; Region: COG0795
449447010479	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
449447010480	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
449447010481	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
449447010482	Walker A/P-loop; other site
449447010483	ATP binding site [chemical binding]; other site
449447010484	Q-loop/lid; other site
449447010485	ABC transporter signature motif; other site
449447010486	Walker B; other site
449447010487	D-loop; other site
449447010488	H-loop/switch region; other site
449447010489	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
449447010490	OstA-like protein; Region: OstA; pfam03968
449447010491	Domain of unknown function (DUF309); Region: DUF309; pfam03745
449447010492	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
449447010493	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
449447010494	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
449447010495	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447010496	active site
449447010497	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
449447010498	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
449447010499	Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233
449447010500	cell division protein; Validated; Region: ftsH; CHL00176
449447010501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447010502	Walker A motif; other site
449447010503	ATP binding site [chemical binding]; other site
449447010504	Walker B motif; other site
449447010505	arginine finger; other site
449447010506	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447010507	DNA polymerase III subunit delta'; Validated; Region: PRK07399
449447010508	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
449447010509	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
449447010510	metal-binding site [ion binding]
449447010511	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447010512	Soluble P-type ATPase [General function prediction only]; Region: COG4087
449447010513	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447010514	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447010515	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447010516	putative active site [active]
449447010517	putative NTP binding site [chemical binding]; other site
449447010518	putative nucleic acid binding site [nucleotide binding]; other site
449447010519	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447010520	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447010521	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447010522	active site
449447010523	Homeodomain-like domain; Region: HTH_23; pfam13384
449447010524	Winged helix-turn helix; Region: HTH_29; pfam13551
449447010525	Homeodomain-like domain; Region: HTH_32; pfam13565
449447010526	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447010527	Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may...; Region: GLECT; cd00070
449447010528	putative alternate dimerization interface [polypeptide binding]; other site
449447010529	sugar binding pocket [chemical binding]; other site
449447010530	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
449447010531	Homeodomain-like domain; Region: HTH_23; pfam13384
449447010532	Winged helix-turn helix; Region: HTH_29; pfam13551
449447010533	Winged helix-turn helix; Region: HTH_33; pfam13592
449447010534	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447010535	PIN domain; Region: PIN_3; pfam13470
449447010536	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
449447010537	Homeodomain-like domain; Region: HTH_23; pfam13384
449447010538	Winged helix-turn helix; Region: HTH_29; pfam13551
449447010539	Homeodomain-like domain; Region: HTH_32; pfam13565
449447010540	Winged helix-turn helix; Region: HTH_33; pfam13592
449447010541	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447010542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010543	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
449447010544	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
449447010545	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
449447010546	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
449447010547	active site
449447010548	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
449447010549	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
449447010550	active site residue [active]
449447010551	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
449447010552	active site residue [active]
449447010553	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
449447010554	Phycobilisome protein; Region: Phycobilisome; cl08227
449447010555	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447010556	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447010557	dimer interface [polypeptide binding]; other site
449447010558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447010559	catalytic residue [active]
449447010560	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
449447010561	MgtC family; Region: MgtC; pfam02308
449447010562	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447010563	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
449447010564	ligand binding site [chemical binding]; other site
449447010565	flexible hinge region; other site
449447010566	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447010567	putative switch regulator; other site
449447010568	non-specific DNA interactions [nucleotide binding]; other site
449447010569	DNA binding site [nucleotide binding]
449447010570	sequence specific DNA binding site [nucleotide binding]; other site
449447010571	putative cAMP binding site [chemical binding]; other site
449447010572	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447010573	Cadmium resistance transporter; Region: Cad; pfam03596
449447010574	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447010575	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447010576	DNA-binding interface [nucleotide binding]; DNA binding site
449447010577	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447010578	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447010579	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
449447010580	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
449447010581	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
449447010582	AAA domain; Region: AAA_21; pfam13304
449447010583	AAA domain; Region: AAA_21; pfam13304
449447010584	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
449447010585	Winged helix-turn helix; Region: HTH_29; pfam13551
449447010586	Homeodomain-like domain; Region: HTH_23; pfam13384
449447010587	Winged helix-turn helix; Region: HTH_33; pfam13592
449447010588	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447010589	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
449447010590	homodimer interface [polypeptide binding]; other site
449447010591	substrate-cofactor binding pocket; other site
449447010592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447010593	catalytic residue [active]
449447010594	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010595	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010596	Probable transposase; Region: OrfB_IS605; pfam01385
449447010597	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010598	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447010599	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
449447010600	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
449447010601	Domain of unknown function (DUF202); Region: DUF202; pfam02656
449447010602	cystathionine gamma-synthase; Provisional; Region: PRK08861
449447010603	Integral membrane protein TerC family; Region: TerC; cl10468
449447010604	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010605	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010606	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010607	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010608	PIN domain; Region: PIN; pfam01850
449447010609	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
449447010610	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
449447010611	Walker A/P-loop; other site
449447010612	ATP binding site [chemical binding]; other site
449447010613	Q-loop/lid; other site
449447010614	ABC transporter signature motif; other site
449447010615	Walker B; other site
449447010616	D-loop; other site
449447010617	H-loop/switch region; other site
449447010618	TOBE domain; Region: TOBE_2; pfam08402
449447010619	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
449447010620	Domain of unknown function (DUF202); Region: DUF202; pfam02656
449447010621	Cadmium resistance transporter; Region: Cad; pfam03596
449447010622	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
449447010623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447010624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447010625	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
449447010626	putative dimerization interface [polypeptide binding]; other site
449447010627	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
449447010628	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447010629	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
449447010630	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447010631	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447010632	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447010633	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
449447010634	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
449447010635	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
449447010636	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
449447010637	RNA binding surface [nucleotide binding]; other site
449447010638	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
449447010639	active site
449447010640	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
449447010641	NAD(P) binding pocket [chemical binding]; other site
449447010642	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
449447010643	Ycf35; Provisional; Region: ycf35; CHL00193
449447010644	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
449447010645	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447010646	putative active site [active]
449447010647	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447010648	putative active site [active]
449447010649	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447010650	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
449447010651	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
449447010652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
449447010653	Zn2+ binding site [ion binding]; other site
449447010654	Mg2+ binding site [ion binding]; other site
449447010655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447010656	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447010657	Calx-beta domain; Region: Calx-beta; cl02522
449447010658	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
449447010659	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
449447010660	Proline dehydrogenase; Region: Pro_dh; pfam01619
449447010661	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
449447010662	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
449447010663	Glutamate binding site [chemical binding]; other site
449447010664	homodimer interface [polypeptide binding]; other site
449447010665	NAD binding site [chemical binding]; other site
449447010666	catalytic residues [active]
449447010667	phosphoglucomutase; Region: PLN02307
449447010668	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
449447010669	substrate binding site [chemical binding]; other site
449447010670	dimer interface [polypeptide binding]; other site
449447010671	active site
449447010672	metal binding site [ion binding]; metal-binding site
449447010673	tellurium resistance terB-like protein; Region: terB_like; cd07177
449447010674	metal binding site [ion binding]; metal-binding site
449447010675	16S rRNA methyltransferase B; Provisional; Region: PRK14901
449447010676	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
449447010677	putative RNA binding site [nucleotide binding]; other site
449447010678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447010679	S-adenosylmethionine binding site [chemical binding]; other site
449447010680	putative hydrolase; Provisional; Region: PRK11460
449447010681	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
449447010682	Helix-turn-helix domain; Region: HTH_19; pfam12844
449447010683	CAAX protease self-immunity; Region: Abi; pfam02517
449447010684	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
449447010685	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010687	binding surface
449447010688	TPR motif; other site
449447010689	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010690	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010692	binding surface
449447010693	TPR motif; other site
449447010694	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010696	binding surface
449447010697	TPR motif; other site
449447010698	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447010699	ribosomal protein L31; Validated; Region: rpl31; CHL00136
449447010700	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
449447010701	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
449447010702	23S rRNA interface [nucleotide binding]; other site
449447010703	L3 interface [polypeptide binding]; other site
449447010704	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
449447010705	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
449447010706	dimerization interface 3.5A [polypeptide binding]; other site
449447010707	active site
449447010708	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
449447010709	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
449447010710	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
449447010711	alphaNTD homodimer interface [polypeptide binding]; other site
449447010712	alphaNTD - beta interaction site [polypeptide binding]; other site
449447010713	alphaNTD - beta' interaction site [polypeptide binding]; other site
449447010714	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
449447010715	30S ribosomal protein S11; Validated; Region: PRK05309
449447010716	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
449447010717	30S ribosomal protein S13; Region: bact_S13; TIGR03631
449447010718	YCII-related domain; Region: YCII; cl00999
449447010719	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
449447010720	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
449447010721	FAD binding domain; Region: FAD_binding_4; pfam01565
449447010722	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
449447010723	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010724	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
449447010725	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
449447010726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447010727	active site
449447010728	phosphorylation site [posttranslational modification]
449447010729	intermolecular recognition site; other site
449447010730	dimerization interface [polypeptide binding]; other site
449447010731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
449447010732	DNA binding site [nucleotide binding]
449447010733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
449447010734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447010735	dimer interface [polypeptide binding]; other site
449447010736	phosphorylation site [posttranslational modification]
449447010737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447010738	ATP binding site [chemical binding]; other site
449447010739	Mg2+ binding site [ion binding]; other site
449447010740	G-X-G motif; other site
449447010741	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
449447010742	PhoU domain; Region: PhoU; pfam01895
449447010743	PhoU domain; Region: PhoU; pfam01895
449447010744	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
449447010745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447010746	dimer interface [polypeptide binding]; other site
449447010747	conserved gate region; other site
449447010748	ABC-ATPase subunit interface; other site
449447010749	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
449447010750	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
449447010751	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
449447010752	HIGH motif; other site
449447010753	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
449447010754	active site
449447010755	KMSKS motif; other site
449447010756	6-phosphofructokinase; Provisional; Region: PRK14071
449447010757	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
449447010758	active site
449447010759	ADP/pyrophosphate binding site [chemical binding]; other site
449447010760	dimerization interface [polypeptide binding]; other site
449447010761	allosteric effector site; other site
449447010762	fructose-1,6-bisphosphate binding site; other site
449447010763	DNA methylase; Region: N6_N4_Mtase; cl17433
449447010764	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447010765	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
449447010766	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
449447010767	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447010768	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
449447010769	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
449447010770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447010771	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447010772	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
449447010773	catalytic residues [active]
449447010774	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
449447010775	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
449447010776	ABC-ATPase subunit  interface; other site
449447010777	dimer interface [polypeptide binding]; other site
449447010778	putative PBP binding regions; other site
449447010779	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
449447010780	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
449447010781	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447010782	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447010783	ligand binding site [chemical binding]; other site
449447010784	flexible hinge region; other site
449447010785	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
449447010786	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
449447010787	putative active site [active]
449447010788	substrate binding site [chemical binding]; other site
449447010789	putative cosubstrate binding site; other site
449447010790	catalytic site [active]
449447010791	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
449447010792	substrate binding site [chemical binding]; other site
449447010793	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
449447010794	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447010795	primosome assembly protein PriA; Validated; Region: PRK05580
449447010796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447010797	ATP binding site [chemical binding]; other site
449447010798	putative Mg++ binding site [ion binding]; other site
449447010799	helicase superfamily c-terminal domain; Region: HELICc; smart00490
449447010800	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
449447010801	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
449447010802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010803	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447010804	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010805	DNA binding residues [nucleotide binding]
449447010806	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
449447010807	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447010808	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447010809	catalytic residue [active]
449447010810	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
449447010811	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447010812	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447010813	DNA binding residues [nucleotide binding]
449447010814	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
449447010815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447010816	Walker A motif; other site
449447010817	ATP binding site [chemical binding]; other site
449447010818	Walker B motif; other site
449447010819	arginine finger; other site
449447010820	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
449447010821	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
449447010822	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
449447010823	substrate binding site [chemical binding]; other site
449447010824	glutamase interaction surface [polypeptide binding]; other site
449447010825	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
449447010826	Domain of unknown function DUF20; Region: UPF0118; pfam01594
449447010827	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
449447010828	RNA/DNA hybrid binding site [nucleotide binding]; other site
449447010829	active site
449447010830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
449447010831	ACT domain; Region: ACT_3; pfam10000
449447010832	Family description; Region: ACT_7; pfam13840
449447010833	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447010834	dimer interface [polypeptide binding]; other site
449447010835	[2Fe-2S] cluster binding site [ion binding]; other site
449447010836	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
449447010837	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
449447010838	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
449447010839	putative active site [active]
449447010840	putative substrate binding site [chemical binding]; other site
449447010841	putative cosubstrate binding site; other site
449447010842	catalytic site [active]
449447010843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
449447010844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
449447010845	putative substrate translocation pore; other site
449447010846	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
449447010847	Protein of unknown function DUF58; Region: DUF58; pfam01882
449447010848	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447010849	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447010850	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447010851	acyl-ACP reductase; Provisional; Region: PRK14982
449447010852	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
449447010853	NAD(P) binding pocket [chemical binding]; other site
449447010854	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
449447010855	dinuclear metal binding motif [ion binding]; other site
449447010856	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
449447010857	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447010858	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
449447010859	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
449447010860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447010861	binding surface
449447010862	TPR motif; other site
449447010863	TPR repeat; Region: TPR_11; pfam13414
449447010864	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
449447010865	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
449447010866	substrate binding site [chemical binding]; other site
449447010867	ligand binding site [chemical binding]; other site
449447010868	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
449447010869	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
449447010870	Mg++ binding site [ion binding]; other site
449447010871	putative catalytic motif [active]
449447010872	putative substrate binding site [chemical binding]; other site
449447010873	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
449447010874	HD domain; Region: HD_4; pfam13328
449447010875	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
449447010876	synthetase active site [active]
449447010877	NTP binding site [chemical binding]; other site
449447010878	metal binding site [ion binding]; metal-binding site
449447010879	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
449447010880	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
449447010881	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
449447010882	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
449447010883	Walker A/P-loop; other site
449447010884	ATP binding site [chemical binding]; other site
449447010885	Q-loop/lid; other site
449447010886	ABC transporter signature motif; other site
449447010887	Walker B; other site
449447010888	D-loop; other site
449447010889	H-loop/switch region; other site
449447010890	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
449447010891	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
449447010892	Walker A/P-loop; other site
449447010893	ATP binding site [chemical binding]; other site
449447010894	Q-loop/lid; other site
449447010895	ABC transporter signature motif; other site
449447010896	Walker B; other site
449447010897	D-loop; other site
449447010898	H-loop/switch region; other site
449447010899	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
449447010900	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447010901	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
449447010902	Probable Catalytic site; other site
449447010903	metal-binding site
449447010904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447010905	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
449447010906	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
449447010907	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
449447010908	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
449447010909	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
449447010910	Walker A/P-loop; other site
449447010911	ATP binding site [chemical binding]; other site
449447010912	Q-loop/lid; other site
449447010913	ABC transporter signature motif; other site
449447010914	Walker B; other site
449447010915	D-loop; other site
449447010916	H-loop/switch region; other site
449447010917	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
449447010918	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
449447010919	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
449447010920	Ligand Binding Site [chemical binding]; other site
449447010921	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
449447010922	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
449447010923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447010924	dimer interface [polypeptide binding]; other site
449447010925	conserved gate region; other site
449447010926	putative PBP binding loops; other site
449447010927	ABC-ATPase subunit interface; other site
449447010928	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
449447010929	NMT1-like family; Region: NMT1_2; pfam13379
449447010930	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
449447010931	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
449447010932	Walker A/P-loop; other site
449447010933	ATP binding site [chemical binding]; other site
449447010934	Q-loop/lid; other site
449447010935	ABC transporter signature motif; other site
449447010936	Walker B; other site
449447010937	D-loop; other site
449447010938	H-loop/switch region; other site
449447010939	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
449447010940	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
449447010941	active site
449447010942	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
449447010943	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
449447010944	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
449447010945	dimer interface [polypeptide binding]; other site
449447010946	ADP-ribose binding site [chemical binding]; other site
449447010947	active site
449447010948	nudix motif; other site
449447010949	metal binding site [ion binding]; metal-binding site
449447010950	ribosomal protein S14; Region: rps14; CHL00074
449447010951	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
449447010952	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
449447010953	RNase E interface [polypeptide binding]; other site
449447010954	trimer interface [polypeptide binding]; other site
449447010955	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
449447010956	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
449447010957	RNase E interface [polypeptide binding]; other site
449447010958	trimer interface [polypeptide binding]; other site
449447010959	active site
449447010960	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
449447010961	putative nucleic acid binding region [nucleotide binding]; other site
449447010962	G-X-X-G motif; other site
449447010963	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
449447010964	RNA binding site [nucleotide binding]; other site
449447010965	domain interface; other site
449447010966	peptide chain release factor 1; Validated; Region: prfA; PRK00591
449447010967	This domain is found in peptide chain release factors; Region: PCRF; smart00937
449447010968	RF-1 domain; Region: RF-1; pfam00472
449447010969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010970	Probable transposase; Region: OrfB_IS605; pfam01385
449447010971	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
449447010972	heterotetramer interface [polypeptide binding]; other site
449447010973	active site pocket [active]
449447010974	cleavage site
449447010975	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
449447010976	DXD motif; other site
449447010977	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447010978	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
449447010979	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
449447010980	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447010981	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
449447010982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010983	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447010984	Probable transposase; Region: OrfB_IS605; pfam01385
449447010985	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447010987	Probable transposase; Region: OrfB_IS605; pfam01385
449447010988	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447010989	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
449447010990	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447010991	active site
449447010992	ATP binding site [chemical binding]; other site
449447010993	substrate binding site [chemical binding]; other site
449447010994	activation loop (A-loop); other site
449447010995	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447010996	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010997	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447010998	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
449447010999	Fatty acid desaturase; Region: FA_desaturase; pfam00487
449447011000	putative di-iron ligands [ion binding]; other site
449447011001	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011002	Tetratricopeptide repeat; Region: TPR_16; pfam13432
449447011003	TPR motif; other site
449447011004	binding surface
449447011005	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447011006	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
449447011007	Walker A/P-loop; other site
449447011008	ATP binding site [chemical binding]; other site
449447011009	Q-loop/lid; other site
449447011010	ABC transporter signature motif; other site
449447011011	Walker B; other site
449447011012	D-loop; other site
449447011013	H-loop/switch region; other site
449447011014	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
449447011015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011016	S-adenosylmethionine binding site [chemical binding]; other site
449447011017	calcium/proton exchanger (cax); Region: cax; TIGR00378
449447011018	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447011019	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
449447011020	Uncharacterized conserved protein [Function unknown]; Region: COG1434
449447011021	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
449447011022	putative active site [active]
449447011023	Peptidase family M50; Region: Peptidase_M50; pfam02163
449447011024	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
449447011025	active site
449447011026	putative substrate binding region [chemical binding]; other site
449447011027	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447011028	thiamine monophosphate kinase; Provisional; Region: PRK05731
449447011029	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
449447011030	ATP binding site [chemical binding]; other site
449447011031	dimerization interface [polypeptide binding]; other site
449447011032	signal recognition particle protein; Provisional; Region: PRK10867
449447011033	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
449447011034	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
449447011035	P loop; other site
449447011036	GTP binding site [chemical binding]; other site
449447011037	Signal peptide binding domain; Region: SRP_SPB; pfam02978
449447011038	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
449447011039	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
449447011040	dimerization interface [polypeptide binding]; other site
449447011041	domain crossover interface; other site
449447011042	redox-dependent activation switch; other site
449447011043	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447011044	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011045	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
449447011046	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011049	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
449447011050	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
449447011051	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
449447011052	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
449447011053	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
449447011054	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
449447011055	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
449447011056	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447011057	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447011058	cofactor binding site; other site
449447011059	DNA binding site [nucleotide binding]
449447011060	substrate interaction site [chemical binding]; other site
449447011061	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447011062	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447011063	DNA-binding interface [nucleotide binding]; DNA binding site
449447011064	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011066	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
449447011067	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
449447011068	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
449447011069	P-loop; other site
449447011070	Magnesium ion binding site [ion binding]; other site
449447011071	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
449447011072	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
449447011073	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
449447011074	Uncharacterized conserved protein [Function unknown]; Region: COG1565
449447011075	lipoyl synthase; Provisional; Region: PRK12928
449447011076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447011077	FeS/SAM binding site; other site
449447011078	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
449447011079	Mechanosensitive ion channel; Region: MS_channel; pfam00924
449447011080	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
449447011081	putative GSH binding site [chemical binding]; other site
449447011082	catalytic residues [active]
449447011083	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
449447011084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011085	Walker A motif; other site
449447011086	ATP binding site [chemical binding]; other site
449447011087	Walker B motif; other site
449447011088	arginine finger; other site
449447011089	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
449447011090	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
449447011091	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
449447011092	[4Fe-4S] binding site [ion binding]; other site
449447011093	molybdopterin cofactor binding site; other site
449447011094	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
449447011095	molybdopterin cofactor binding site; other site
449447011096	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430
449447011097	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447011098	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
449447011099	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
449447011100	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
449447011101	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
449447011102	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
449447011103	glycogen branching enzyme; Provisional; Region: PRK05402
449447011104	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
449447011105	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
449447011106	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
449447011107	active site
449447011108	catalytic site [active]
449447011109	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
449447011110	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
449447011111	Fasciclin domain; Region: Fasciclin; pfam02469
449447011112	ribonuclease Z; Region: RNase_Z; TIGR02651
449447011113	Tubulin like; Region: Tubulin_2; pfam13809
449447011114	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
449447011115	Double zinc ribbon; Region: DZR; pfam12773
449447011116	ornithine carbamoyltransferase; Provisional; Region: PRK00779
449447011117	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
449447011118	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
449447011119	4-alpha-glucanotransferase; Provisional; Region: PRK14508
449447011120	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011121	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011122	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447011123	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447011124	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
449447011125	DNA binding residues [nucleotide binding]
449447011126	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
449447011127	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
449447011128	molybdopterin cofactor binding site; other site
449447011129	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
449447011130	molybdopterin cofactor binding site; other site
449447011131	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011132	DDE superfamily endonuclease; Region: DDE_4; cl17710
449447011133	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011134	DDE superfamily endonuclease; Region: DDE_4; cl17710
449447011135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
449447011136	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
449447011137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447011138	motif II; other site
449447011139	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
449447011140	Pantoate-beta-alanine ligase; Region: PanC; cd00560
449447011141	active site
449447011142	ATP-binding site [chemical binding]; other site
449447011143	pantoate-binding site; other site
449447011144	HXXH motif; other site
449447011145	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
449447011146	CMP-binding site; other site
449447011147	The sites determining sugar specificity; other site
449447011148	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
449447011149	Uncharacterized conserved protein [Function unknown]; Region: COG3937
449447011150	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
449447011151	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
449447011152	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
449447011153	Protein of unknown function (DUF3344); Region: DUF3344; pfam11824
449447011154	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
449447011155	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
449447011156	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
449447011157	2-isopropylmalate synthase; Validated; Region: PRK00915
449447011158	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
449447011159	active site
449447011160	catalytic residues [active]
449447011161	metal binding site [ion binding]; metal-binding site
449447011162	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
449447011163	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
449447011164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
449447011165	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
449447011166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
449447011167	DNA binding residues [nucleotide binding]
449447011168	ribosomal protein S20; Region: rps20; CHL00102
449447011169	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
449447011170	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
449447011171	active site
449447011172	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
449447011173	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
449447011174	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
449447011175	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
449447011176	RPB1 interaction site [polypeptide binding]; other site
449447011177	RPB10 interaction site [polypeptide binding]; other site
449447011178	RPB11 interaction site [polypeptide binding]; other site
449447011179	RPB3 interaction site [polypeptide binding]; other site
449447011180	RPB12 interaction site [polypeptide binding]; other site
449447011181	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
449447011182	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
449447011183	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
449447011184	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
449447011185	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
449447011186	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
449447011187	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
449447011188	DNA binding site [nucleotide binding]
449447011189	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
449447011190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
449447011191	Coenzyme A binding pocket [chemical binding]; other site
449447011192	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
449447011193	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
449447011194	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
449447011195	ligand binding site [chemical binding]; other site
449447011196	flexible hinge region; other site
449447011197	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
449447011198	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
449447011199	putative active site [active]
449447011200	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447011201	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
449447011202	Walker A/P-loop; other site
449447011203	ATP binding site [chemical binding]; other site
449447011204	Q-loop/lid; other site
449447011205	ABC transporter signature motif; other site
449447011206	Walker B; other site
449447011207	D-loop; other site
449447011208	H-loop/switch region; other site
449447011209	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
449447011210	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
449447011211	HlyD family secretion protein; Region: HlyD_3; pfam13437
449447011212	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
449447011213	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
449447011214	catalytic residues [active]
449447011215	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
449447011216	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447011217	DNA binding residues [nucleotide binding]
449447011218	dimerization interface [polypeptide binding]; other site
449447011219	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
449447011220	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
449447011221	Homeodomain-like domain; Region: HTH_32; pfam13565
449447011222	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011223	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011224	Probable transposase; Region: OrfB_IS605; pfam01385
449447011225	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011226	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
449447011227	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
449447011228	active site
449447011229	catalytic site [active]
449447011230	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
449447011231	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
449447011232	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
449447011233	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
449447011234	CHAT domain; Region: CHAT; cl17868
449447011235	WD domain, G-beta repeat; Region: WD40; pfam00400
449447011236	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447011237	structural tetrad; other site
449447011238	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447011239	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447011240	structural tetrad; other site
449447011241	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
449447011242	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
449447011243	N-acetyl-D-glucosamine binding site [chemical binding]; other site
449447011244	catalytic residue [active]
449447011245	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
449447011246	putative active site [active]
449447011247	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
449447011248	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
449447011249	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
449447011250	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
449447011251	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
449447011252	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011253	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011254	Probable transposase; Region: OrfB_IS605; pfam01385
449447011255	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011256	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
449447011257	Protein of unknown function, DUF393; Region: DUF393; cl01136
449447011258	Protein of unknown function (DUF760); Region: DUF760; pfam05542
449447011259	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
449447011260	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
449447011261	active site
449447011262	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
449447011263	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447011264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447011265	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447011266	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447011267	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447011268	structural tetrad; other site
449447011269	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447011270	structural tetrad; other site
449447011271	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447011272	active site
449447011273	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
449447011274	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
449447011275	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
449447011276	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011277	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011278	Homeodomain-like domain; Region: HTH_23; pfam13384
449447011279	Homeodomain-like domain; Region: HTH_32; pfam13565
449447011280	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011282	CHAT domain; Region: CHAT; pfam12770
449447011283	CHAT domain; Region: CHAT; cl17868
449447011284	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011286	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447011287	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447011288	DNA-binding interface [nucleotide binding]; DNA binding site
449447011289	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011290	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011291	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
449447011292	Paired Box domain; Region: PAX; cd00131
449447011293	DNA binding site [nucleotide binding]
449447011294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011295	TPR motif; other site
449447011296	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011297	binding surface
449447011298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011299	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
449447011300	putative addiction module antidote; Region: doc_partner; TIGR02609
449447011301	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
449447011302	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
449447011303	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011304	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
449447011305	PUCC protein; Region: PUCC; pfam03209
449447011306	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447011307	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011308	active site
449447011309	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
449447011310	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869
449447011311	arogenate dehydrogenase; Reviewed; Region: PRK07417
449447011312	prephenate dehydrogenase; Validated; Region: PRK08507
449447011313	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
449447011314	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
449447011315	putative hydrophobic ligand binding site [chemical binding]; other site
449447011316	Probable transposase; Region: OrfB_IS605; pfam01385
449447011317	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011318	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447011319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
449447011320	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
449447011321	phosphatidate cytidylyltransferase; Region: PLN02953
449447011322	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
449447011323	active site
449447011324	SAM binding site [chemical binding]; other site
449447011325	homodimer interface [polypeptide binding]; other site
449447011326	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
449447011327	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
449447011328	active site
449447011329	14-3-3 domain; Region: 14-3-3; cl02098
449447011330	dimer interface [polypeptide binding]; other site
449447011331	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447011332	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447011333	Hexamer interface [polypeptide binding]; other site
449447011334	Hexagonal pore residue; other site
449447011335	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
449447011336	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
449447011337	Hexamer interface [polypeptide binding]; other site
449447011338	Hexagonal pore residue; other site
449447011339	methionine sulfoxide reductase A; Provisional; Region: PRK13014
449447011340	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
449447011341	oligomerization interface [polypeptide binding]; other site
449447011342	active site
449447011343	metal binding site [ion binding]; metal-binding site
449447011344	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
449447011345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011346	S-adenosylmethionine binding site [chemical binding]; other site
449447011347	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
449447011348	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
449447011349	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
449447011350	domain interfaces; other site
449447011351	active site
449447011352	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
449447011353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
449447011354	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447011355	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011356	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011357	Homeodomain-like domain; Region: HTH_23; pfam13384
449447011358	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447011359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447011360	conserved gate region; other site
449447011361	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
449447011362	dimer interface [polypeptide binding]; other site
449447011363	putative PBP binding loops; other site
449447011364	ABC-ATPase subunit interface; other site
449447011365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447011366	Walker A/P-loop; other site
449447011367	ATP binding site [chemical binding]; other site
449447011368	ABC transporter; Region: ABC_tran; pfam00005
449447011369	Q-loop/lid; other site
449447011370	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
449447011371	ABC transporter signature motif; other site
449447011372	Walker B; other site
449447011373	D-loop; other site
449447011374	H-loop/switch region; other site
449447011375	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
449447011376	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
449447011377	AMIN domain; Region: AMIN; pfam11741
449447011378	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
449447011379	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447011380	active site
449447011381	metal binding site [ion binding]; metal-binding site
449447011382	glutamate racemase; Provisional; Region: PRK00865
449447011383	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447011384	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447011385	Winged helix-turn helix; Region: HTH_29; pfam13551
449447011386	Homeodomain-like domain; Region: HTH_23; pfam13384
449447011387	Homeodomain-like domain; Region: HTH_32; pfam13565
449447011388	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011390	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447011391	active site
449447011392	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
449447011393	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
449447011394	Substrate binding site; other site
449447011395	Mg++ binding site; other site
449447011396	metal-binding site
449447011397	Mg++ binding site; other site
449447011398	metal-binding site
449447011399	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
449447011400	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
449447011401	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
449447011402	dimer interface [polypeptide binding]; other site
449447011403	active site
449447011404	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
449447011405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447011406	active site
449447011407	motif I; other site
449447011408	motif II; other site
449447011409	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447011410	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
449447011411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447011412	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
449447011413	YcfA-like protein; Region: YcfA; pfam07927
449447011414	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
449447011415	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
449447011416	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447011417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447011418	non-specific DNA binding site [nucleotide binding]; other site
449447011419	salt bridge; other site
449447011420	sequence-specific DNA binding site [nucleotide binding]; other site
449447011421	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
449447011422	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447011423	non-specific DNA binding site [nucleotide binding]; other site
449447011424	salt bridge; other site
449447011425	sequence-specific DNA binding site [nucleotide binding]; other site
449447011426	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
449447011427	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447011428	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447011429	active site
449447011430	ATP binding site [chemical binding]; other site
449447011431	substrate binding site [chemical binding]; other site
449447011432	activation loop (A-loop); other site
449447011433	Uncharacterized conserved protein [Function unknown]; Region: COG1262
449447011434	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
449447011435	AAA domain; Region: AAA_13; pfam13166
449447011436	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
449447011437	Walker A motif; other site
449447011438	ATP binding site [chemical binding]; other site
449447011439	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
449447011440	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
449447011441	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447011442	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
449447011443	pyrroline-5-carboxylate reductase; Region: PLN02688
449447011444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
449447011445	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
449447011446	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
449447011447	catalytic residue [active]
449447011448	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
449447011449	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
449447011450	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447011451	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
449447011452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447011453	S-adenosylmethionine binding site [chemical binding]; other site
449447011454	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
449447011455	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447011456	GTP-binding protein YchF; Reviewed; Region: PRK09601
449447011457	YchF GTPase; Region: YchF; cd01900
449447011458	G1 box; other site
449447011459	GTP/Mg2+ binding site [chemical binding]; other site
449447011460	Switch I region; other site
449447011461	G2 box; other site
449447011462	Switch II region; other site
449447011463	G3 box; other site
449447011464	G4 box; other site
449447011465	G5 box; other site
449447011466	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
449447011467	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
449447011468	elongation factor G; Reviewed; Region: PRK12740
449447011469	G1 box; other site
449447011470	putative GEF interaction site [polypeptide binding]; other site
449447011471	GTP/Mg2+ binding site [chemical binding]; other site
449447011472	Switch I region; other site
449447011473	G2 box; other site
449447011474	G3 box; other site
449447011475	Switch II region; other site
449447011476	G4 box; other site
449447011477	G5 box; other site
449447011478	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
449447011479	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
449447011480	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
449447011481	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447011482	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
449447011483	XisI protein; Region: XisI; pfam08869
449447011484	XisH protein; Region: XisH; pfam08814
449447011485	Uncharacterized conserved protein [Function unknown]; Region: COG2442
449447011486	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
449447011487	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
449447011488	Domain of unknown function (DUF1902); Region: DUF1902; pfam08972
449447011489	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447011490	putative active site [active]
449447011491	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
449447011492	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
449447011493	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
449447011494	XisI protein; Region: XisI; pfam08869
449447011495	TIR domain; Region: TIR_2; pfam13676
449447011496	AAA ATPase domain; Region: AAA_16; pfam13191
449447011497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011498	binding surface
449447011499	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011500	TPR motif; other site
449447011501	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011502	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011504	binding surface
449447011505	TPR motif; other site
449447011506	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011509	binding surface
449447011510	TPR motif; other site
449447011511	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447011512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447011513	binding surface
449447011514	TPR motif; other site
449447011515	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
449447011516	L-aspartate oxidase; Provisional; Region: PRK06175
449447011517	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
449447011518	plastocyanin; Provisional; Region: PRK02710
449447011519	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
449447011520	Cytochrome c; Region: Cytochrom_C; cl11414
449447011521	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
449447011522	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
449447011523	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
449447011524	Transposase domain (DUF772); Region: DUF772; pfam05598
449447011525	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
449447011526	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
449447011527	catalytic triad [active]
449447011528	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
449447011529	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
449447011530	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
449447011531	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447011532	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447011533	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
449447011534	protein binding site [polypeptide binding]; other site
449447011535	Protein of unknown function DUF262; Region: DUF262; pfam03235
449447011536	Uncharacterized conserved protein [Function unknown]; Region: COG1479
449447011537	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
449447011538	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
449447011539	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
449447011540	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
449447011541	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
449447011542	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
449447011543	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011544	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
449447011545	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
449447011546	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447011547	active site
449447011548	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447011549	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
449447011550	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
449447011551	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
449447011552	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
449447011553	trimer interface [polypeptide binding]; other site
449447011554	active site
449447011555	substrate binding site [chemical binding]; other site
449447011556	CoA binding site [chemical binding]; other site
449447011557	Condensation domain; Region: Condensation; pfam00668
449447011558	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
449447011559	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011560	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447011561	acyl-activating enzyme (AAE) consensus motif; other site
449447011562	AMP binding site [chemical binding]; other site
449447011563	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447011564	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
449447011565	putative NAD(P) binding site [chemical binding]; other site
449447011566	active site
449447011567	putative substrate binding site [chemical binding]; other site
449447011568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447011569	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447011570	NAD(P) binding site [chemical binding]; other site
449447011571	active site
449447011572	Condensation domain; Region: Condensation; pfam00668
449447011573	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447011574	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011575	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447011576	acyl-activating enzyme (AAE) consensus motif; other site
449447011577	AMP binding site [chemical binding]; other site
449447011578	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447011579	Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364
449447011580	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
449447011581	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
449447011582	putative NAD(P) binding site [chemical binding]; other site
449447011583	putative active site [active]
449447011584	Cupin domain; Region: Cupin_2; pfam07883
449447011585	Prephenate dehydratase; Region: PDT; pfam00800
449447011586	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
449447011587	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
449447011588	homotetramer interface [polypeptide binding]; other site
449447011589	FMN binding site [chemical binding]; other site
449447011590	homodimer contacts [polypeptide binding]; other site
449447011591	putative active site [active]
449447011592	putative substrate binding site [chemical binding]; other site
449447011593	Condensation domain; Region: Condensation; pfam00668
449447011594	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447011595	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447011596	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447011597	acyl-activating enzyme (AAE) consensus motif; other site
449447011598	AMP binding site [chemical binding]; other site
449447011599	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447011600	Condensation domain; Region: Condensation; pfam00668
449447011601	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
449447011602	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447011603	The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906
449447011604	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
449447011605	acyl-activating enzyme (AAE) consensus motif; other site
449447011606	putative AMP binding site [chemical binding]; other site
449447011607	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
449447011608	putative NADP binding site [chemical binding]; other site
449447011609	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
449447011610	active site
449447011611	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447011612	Uncharacterized conserved protein [Function unknown]; Region: COG4279
449447011613	SWIM zinc finger; Region: SWIM; pfam04434
449447011614	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447011615	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447011616	DNA-binding interface [nucleotide binding]; DNA binding site
449447011617	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447011618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447011619	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
449447011620	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
449447011621	active site
449447011622	interdomain interaction site; other site
449447011623	putative metal-binding site [ion binding]; other site
449447011624	nucleotide binding site [chemical binding]; other site
449447011625	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
449447011626	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
449447011627	domain II; other site
449447011628	domain III; other site
449447011629	nucleotide binding site [chemical binding]; other site
449447011630	DNA binding groove [nucleotide binding]
449447011631	catalytic site [active]
449447011632	domain IV; other site
449447011633	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447011634	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447011635	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
449447011636	Protein of unknown function (DUF938); Region: DUF938; pfam06080
449447011637	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
449447011638	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
449447011639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447011640	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447011641	Probable transposase; Region: OrfB_IS605; pfam01385
449447011642	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447011643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011644	binding surface
449447011645	TPR motif; other site
449447011646	TPR repeat; Region: TPR_11; pfam13414
449447011647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011648	binding surface
449447011649	TPR repeat; Region: TPR_11; pfam13414
449447011650	TPR motif; other site
449447011651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011652	TPR motif; other site
449447011653	TPR repeat; Region: TPR_11; pfam13414
449447011654	binding surface
449447011655	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447011656	Creatinine amidohydrolase; Region: Creatininase; pfam02633
449447011657	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
449447011658	active site
449447011659	multimer interface [polypeptide binding]; other site
449447011660	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
449447011661	HD domain; Region: HD_5; pfam13487
449447011662	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
449447011663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
449447011664	FeS/SAM binding site; other site
449447011665	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
449447011666	CpeS-like protein; Region: CpeS; pfam09367
449447011667	HEAT repeats; Region: HEAT_2; pfam13646
449447011668	HEAT repeats; Region: HEAT_2; pfam13646
449447011669	HEAT repeats; Region: HEAT_2; pfam13646
449447011670	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011671	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011672	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447011673	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011674	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011675	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011676	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
449447011677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
449447011678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447011679	homodimer interface [polypeptide binding]; other site
449447011680	catalytic residue [active]
449447011681	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
449447011682	catalytic residues [active]
449447011683	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
449447011684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
449447011685	putative PBP binding loops; other site
449447011686	dimer interface [polypeptide binding]; other site
449447011687	ABC-ATPase subunit interface; other site
449447011688	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
449447011689	putative dimer interface [polypeptide binding]; other site
449447011690	active site pocket [active]
449447011691	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
449447011692	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
449447011693	putative NAD(P) binding site [chemical binding]; other site
449447011694	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
449447011695	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
449447011696	carboxyltransferase (CT) interaction site; other site
449447011697	biotinylation site [posttranslational modification]; other site
449447011698	elongation factor P; Validated; Region: PRK00529
449447011699	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
449447011700	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
449447011701	RNA binding site [nucleotide binding]; other site
449447011702	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
449447011703	RNA binding site [nucleotide binding]; other site
449447011704	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
449447011705	HsdM N-terminal domain; Region: HsdM_N; pfam12161
449447011706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
449447011707	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011708	active site
449447011709	NTP binding site [chemical binding]; other site
449447011710	metal binding triad [ion binding]; metal-binding site
449447011711	antibiotic binding site [chemical binding]; other site
449447011712	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011713	active site
449447011714	NTP binding site [chemical binding]; other site
449447011715	metal binding triad [ion binding]; metal-binding site
449447011716	antibiotic binding site [chemical binding]; other site
449447011717	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447011718	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
449447011719	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
449447011720	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
449447011721	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
449447011722	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
449447011723	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447011724	ATP binding site [chemical binding]; other site
449447011725	putative Mg++ binding site [ion binding]; other site
449447011726	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
449447011727	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011728	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011729	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447011730	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011731	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447011732	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011733	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011734	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011735	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011736	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011737	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011738	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011739	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011740	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
449447011741	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
449447011742	putative lipid kinase; Reviewed; Region: PRK13057
449447011743	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
449447011744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
449447011745	substrate binding pocket [chemical binding]; other site
449447011746	membrane-bound complex binding site; other site
449447011747	hinge residues; other site
449447011748	Integral membrane protein DUF92; Region: DUF92; pfam01940
449447011749	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
449447011750	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
449447011751	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447011752	catalytic loop [active]
449447011753	iron binding site [ion binding]; other site
449447011754	cobyric acid synthase; Provisional; Region: PRK00784
449447011755	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
449447011756	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
449447011757	catalytic triad [active]
449447011758	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
449447011759	dimer interface [polypeptide binding]; other site
449447011760	[2Fe-2S] cluster binding site [ion binding]; other site
449447011761	response regulator FixJ; Provisional; Region: fixJ; PRK09390
449447011762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447011763	active site
449447011764	phosphorylation site [posttranslational modification]
449447011765	intermolecular recognition site; other site
449447011766	dimerization interface [polypeptide binding]; other site
449447011767	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
449447011768	DNA binding residues [nucleotide binding]
449447011769	dimerization interface [polypeptide binding]; other site
449447011770	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
449447011771	Clp protease; Region: CLP_protease; pfam00574
449447011772	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447011773	oligomer interface [polypeptide binding]; other site
449447011774	active site residues [active]
449447011775	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
449447011776	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447011777	oligomer interface [polypeptide binding]; other site
449447011778	active site residues [active]
449447011779	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
449447011780	DNA methylase; Region: N6_N4_Mtase; cl17433
449447011781	adenylate kinase; Provisional; Region: adk; PRK02496
449447011782	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
449447011783	AMP-binding site [chemical binding]; other site
449447011784	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
449447011785	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
449447011786	SecY translocase; Region: SecY; pfam00344
449447011787	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
449447011788	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
449447011789	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
449447011790	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
449447011791	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
449447011792	23S rRNA interface [nucleotide binding]; other site
449447011793	5S rRNA interface [nucleotide binding]; other site
449447011794	L27 interface [polypeptide binding]; other site
449447011795	L5 interface [polypeptide binding]; other site
449447011796	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
449447011797	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
449447011798	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
449447011799	ribosomal protein S8; Region: rps8; CHL00042
449447011800	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
449447011801	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
449447011802	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
449447011803	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
449447011804	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
449447011805	RNA binding site [nucleotide binding]; other site
449447011806	ribosomal protein L14; Region: rpl14; CHL00057
449447011807	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
449447011808	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
449447011809	23S rRNA interface [nucleotide binding]; other site
449447011810	putative translocon interaction site; other site
449447011811	signal recognition particle (SRP54) interaction site; other site
449447011812	L23 interface [polypeptide binding]; other site
449447011813	trigger factor interaction site; other site
449447011814	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
449447011815	23S rRNA interface [nucleotide binding]; other site
449447011816	5S rRNA interface [nucleotide binding]; other site
449447011817	putative antibiotic binding site [chemical binding]; other site
449447011818	L25 interface [polypeptide binding]; other site
449447011819	L27 interface [polypeptide binding]; other site
449447011820	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
449447011821	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
449447011822	G-X-X-G motif; other site
449447011823	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
449447011824	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
449447011825	putative translocon binding site; other site
449447011826	protein-rRNA interface [nucleotide binding]; other site
449447011827	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
449447011828	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
449447011829	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
449447011830	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
449447011831	ribosomal protein L23; Region: rpl23; CHL00030
449447011832	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
449447011833	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
449447011834	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
449447011835	Nitrogen regulatory protein P-II; Region: P-II; smart00938
449447011836	indole-3-acetic acid-amido synthetase; Region: PLN02247
449447011837	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
449447011838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
449447011839	Uncharacterized conserved protein [Function unknown]; Region: COG3339
449447011840	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
449447011841	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
449447011842	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
449447011843	metal binding site 2 [ion binding]; metal-binding site
449447011844	putative DNA binding helix; other site
449447011845	metal binding site 1 [ion binding]; metal-binding site
449447011846	dimer interface [polypeptide binding]; other site
449447011847	structural Zn2+ binding site [ion binding]; other site
449447011848	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
449447011849	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
449447011850	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
449447011851	putative active site [active]
449447011852	catalytic triad [active]
449447011853	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
449447011854	Cation efflux family; Region: Cation_efflux; cl00316
449447011855	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
449447011856	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
449447011857	NAD binding site [chemical binding]; other site
449447011858	substrate binding site [chemical binding]; other site
449447011859	homodimer interface [polypeptide binding]; other site
449447011860	active site
449447011861	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
449447011862	KH domain; Region: KH_4; pfam13083
449447011863	GTPase CgtA; Reviewed; Region: obgE; PRK12299
449447011864	GTP1/OBG; Region: GTP1_OBG; pfam01018
449447011865	Obg GTPase; Region: Obg; cd01898
449447011866	G1 box; other site
449447011867	GTP/Mg2+ binding site [chemical binding]; other site
449447011868	Switch I region; other site
449447011869	G2 box; other site
449447011870	G3 box; other site
449447011871	Switch II region; other site
449447011872	G4 box; other site
449447011873	G5 box; other site
449447011874	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447011875	HEPN domain; Region: HEPN; cl00824
449447011876	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
449447011877	active site
449447011878	NTP binding site [chemical binding]; other site
449447011879	metal binding triad [ion binding]; metal-binding site
449447011880	antibiotic binding site [chemical binding]; other site
449447011881	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447011882	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447011883	NB-ARC domain; Region: NB-ARC; pfam00931
449447011884	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447011885	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
449447011886	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
449447011887	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
449447011888	ScpA/B protein; Region: ScpA_ScpB; cl00598
449447011889	ScpA/B protein; Region: ScpA_ScpB; cl00598
449447011890	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
449447011891	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
449447011892	Domain of unknown function DUF21; Region: DUF21; pfam01595
449447011893	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
449447011894	Transporter associated domain; Region: CorC_HlyC; smart01091
449447011895	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011896	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011897	proton extrusion protein PcxA; Provisional; Region: PRK02507
449447011898	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447011899	non-specific DNA binding site [nucleotide binding]; other site
449447011900	salt bridge; other site
449447011901	sequence-specific DNA binding site [nucleotide binding]; other site
449447011902	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447011903	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
449447011904	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
449447011905	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
449447011906	dimerization interface [polypeptide binding]; other site
449447011907	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
449447011908	ATP binding site [chemical binding]; other site
449447011909	Uncharacterized conserved protein [Function unknown]; Region: COG5464
449447011910	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
449447011911	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
449447011912	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
449447011913	generic binding surface II; other site
449447011914	generic binding surface I; other site
449447011915	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
449447011916	ATP binding site [chemical binding]; other site
449447011917	putative Mg++ binding site [ion binding]; other site
449447011918	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
449447011919	nucleotide binding region [chemical binding]; other site
449447011920	ATP-binding site [chemical binding]; other site
449447011921	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
449447011922	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
449447011923	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
449447011924	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
449447011925	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
449447011926	catalytic loop [active]
449447011927	iron binding site [ion binding]; other site
449447011928	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
449447011929	4Fe-4S binding domain; Region: Fer4; pfam00037
449447011930	hybrid cluster protein; Provisional; Region: PRK05290
449447011931	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011932	ACS interaction site; other site
449447011933	CODH interaction site; other site
449447011934	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447011935	ACS interaction site; other site
449447011936	CODH interaction site; other site
449447011937	metal cluster binding site [ion binding]; other site
449447011938	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
449447011939	putative active site [active]
449447011940	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
449447011941	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
449447011942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011943	TPR repeat; Region: TPR_11; pfam13414
449447011944	binding surface
449447011945	TPR motif; other site
449447011946	TPR repeat; Region: TPR_11; pfam13414
449447011947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011948	binding surface
449447011949	TPR motif; other site
449447011950	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447011951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011952	binding surface
449447011953	TPR motif; other site
449447011954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011955	binding surface
449447011956	TPR motif; other site
449447011957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011958	binding surface
449447011959	TPR motif; other site
449447011960	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
449447011961	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011962	binding surface
449447011963	TPR motif; other site
449447011964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011965	binding surface
449447011966	TPR motif; other site
449447011967	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447011968	binding surface
449447011969	TPR motif; other site
449447011970	TPR repeat; Region: TPR_11; pfam13414
449447011971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447011972	Walker A motif; other site
449447011973	ATP binding site [chemical binding]; other site
449447011974	Walker B motif; other site
449447011975	arginine finger; other site
449447011976	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011977	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447011978	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447011979	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447011980	yiaA/B two helix domain; Region: YiaAB; cl01759
449447011981	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
449447011982	protein I interface; other site
449447011983	D2 interface; other site
449447011984	protein T interface; other site
449447011985	chlorophyll binding site; other site
449447011986	beta carotene binding site; other site
449447011987	pheophytin binding site; other site
449447011988	manganese-stabilizing polypeptide interface; other site
449447011989	CP43 interface; other site
449447011990	protein L interface; other site
449447011991	oxygen evolving complex binding site; other site
449447011992	bromide binding site; other site
449447011993	quinone binding site; other site
449447011994	Fe binding site [ion binding]; other site
449447011995	core light harvesting interface; other site
449447011996	cytochrome b559 alpha subunit interface; other site
449447011997	cytochrome c-550 interface; other site
449447011998	protein J interface; other site
449447011999	PemK-like protein; Region: PemK; pfam02452
449447012000	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
449447012001	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
449447012002	Stage II sporulation protein; Region: SpoIID; pfam08486
449447012003	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
449447012004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
449447012005	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
449447012006	active site
449447012007	metal binding site [ion binding]; metal-binding site
449447012008	Uncharacterized conserved protein [Function unknown]; Region: COG2912
449447012009	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
449447012010	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
449447012011	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
449447012012	active site
449447012013	metal binding site [ion binding]; metal-binding site
449447012014	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
449447012015	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
449447012016	active site
449447012017	dimer interface [polypeptide binding]; other site
449447012018	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
449447012019	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
449447012020	active site
449447012021	catalytic tetrad [active]
449447012022	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
449447012023	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
449447012024	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
449447012025	GSH binding site [chemical binding]; other site
449447012026	catalytic residues [active]
449447012027	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
449447012028	nucleoside/Zn binding site; other site
449447012029	dimer interface [polypeptide binding]; other site
449447012030	catalytic motif [active]
449447012031	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
449447012032	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
449447012033	non-specific DNA binding site [nucleotide binding]; other site
449447012034	salt bridge; other site
449447012035	sequence-specific DNA binding site [nucleotide binding]; other site
449447012036	Leucine rich repeat; Region: LRR_8; pfam13855
449447012037	Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310
449447012038	GXWXG protein; Region: GXWXG; pfam14231
449447012039	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
449447012040	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
449447012041	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
449447012042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
449447012043	catalytic residue [active]
449447012044	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
449447012045	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
449447012046	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
449447012047	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
449447012048	acyl-activating enzyme (AAE) consensus motif; other site
449447012049	putative AMP binding site [chemical binding]; other site
449447012050	putative active site [active]
449447012051	putative CoA binding site [chemical binding]; other site
449447012052	O-succinylbenzoate synthase; Provisional; Region: PRK02714
449447012053	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
449447012054	active site
449447012055	Homeodomain-like domain; Region: HTH_23; pfam13384
449447012056	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012057	Winged helix-turn helix; Region: HTH_33; pfam13592
449447012058	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012059	Homeodomain-like domain; Region: HTH_23; pfam13384
449447012060	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012061	Homeodomain-like domain; Region: HTH_32; pfam13565
449447012062	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012063	Calx-beta domain; Region: Calx-beta; cl02522
449447012064	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447012065	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447012066	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447012067	ARD/ARD' family; Region: ARD; pfam03079
449447012068	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447012069	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447012070	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447012071	putative active site [active]
449447012072	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447012073	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
449447012074	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
449447012075	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
449447012076	DXD motif; other site
449447012077	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
449447012078	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
449447012079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447012080	NAD(P) binding site [chemical binding]; other site
449447012081	active site
449447012082	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
449447012083	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
449447012084	putative NAD(P) binding site [chemical binding]; other site
449447012085	Phosphopantetheine attachment site; Region: PP-binding; cl09936
449447012086	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
449447012087	Ligand Binding Site [chemical binding]; other site
449447012088	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
449447012089	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
449447012090	Competence protein; Region: Competence; pfam03772
449447012091	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
449447012092	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
449447012093	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447012094	oligomer interface [polypeptide binding]; other site
449447012095	tandem repeat interface [polypeptide binding]; other site
449447012096	active site residues [active]
449447012097	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
449447012098	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
449447012099	tandem repeat interface [polypeptide binding]; other site
449447012100	oligomer interface [polypeptide binding]; other site
449447012101	active site residues [active]
449447012102	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447012103	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
449447012104	cofactor binding site; other site
449447012105	DNA binding site [nucleotide binding]
449447012106	substrate interaction site [chemical binding]; other site
449447012107	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447012108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447012109	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
449447012110	DNA methylase; Region: N6_N4_Mtase; pfam01555
449447012111	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
449447012112	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
449447012113	G1 box; other site
449447012114	putative GEF interaction site [polypeptide binding]; other site
449447012115	GTP/Mg2+ binding site [chemical binding]; other site
449447012116	Switch I region; other site
449447012117	G2 box; other site
449447012118	G3 box; other site
449447012119	Switch II region; other site
449447012120	G4 box; other site
449447012121	G5 box; other site
449447012122	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
449447012123	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
449447012124	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
449447012125	putative acyl-acceptor binding pocket; other site
449447012126	Predicted transcriptional regulators [Transcription]; Region: COG1725
449447012127	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
449447012128	DNA-binding site [nucleotide binding]; DNA binding site
449447012129	von Willebrand factor type A domain; Region: VWA_2; pfam13519
449447012130	Tubulin like; Region: Tubulin_2; pfam13809
449447012131	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
449447012132	phosphodiesterase; Provisional; Region: PRK12704
449447012133	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
449447012134	ligand binding site [chemical binding]; other site
449447012135	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
449447012136	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012137	putative active site [active]
449447012138	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012139	putative active site [active]
449447012140	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
449447012141	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
449447012142	acyl-activating enzyme (AAE) consensus motif; other site
449447012143	putative AMP binding site [chemical binding]; other site
449447012144	putative active site [active]
449447012145	putative CoA binding site [chemical binding]; other site
449447012146	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
449447012147	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
449447012148	Uncharacterized conserved protein [Function unknown]; Region: COG4278
449447012149	TIGR04222 domain; Region: near_uncomplex
449447012150	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
449447012151	Domain of unknown function (DUF814); Region: DUF814; pfam05670
449447012152	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
449447012153	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
449447012154	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447012155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012156	binding surface
449447012157	TPR motif; other site
449447012158	TPR repeat; Region: TPR_11; pfam13414
449447012159	TPR repeat; Region: TPR_11; pfam13414
449447012160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012161	binding surface
449447012162	TPR motif; other site
449447012163	TPR repeat; Region: TPR_11; pfam13414
449447012164	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012165	binding surface
449447012166	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447012167	TPR motif; other site
449447012168	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
449447012169	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
449447012170	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
449447012171	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
449447012172	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
449447012173	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
449447012174	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447012175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
449447012176	binding surface
449447012177	TPR motif; other site
449447012178	Tetratricopeptide repeat; Region: TPR_12; pfam13424
449447012179	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
449447012180	Uncharacterized conserved protein [Function unknown]; Region: COG1432
449447012181	LabA_like proteins; Region: LabA; cd10911
449447012182	putative metal binding site [ion binding]; other site
449447012183	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
449447012184	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
449447012185	active site residue [active]
449447012186	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
449447012187	active site residue [active]
449447012188	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
449447012189	Response regulator receiver domain; Region: Response_reg; pfam00072
449447012190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447012191	active site
449447012192	phosphorylation site [posttranslational modification]
449447012193	intermolecular recognition site; other site
449447012194	dimerization interface [polypeptide binding]; other site
449447012195	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
449447012196	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
449447012197	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
449447012198	anti sigma factor interaction site; other site
449447012199	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
449447012200	regulatory phosphorylation site [posttranslational modification]; other site
449447012201	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
449447012202	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
449447012203	Probable transposase; Region: OrfB_IS605; pfam01385
449447012204	Probable transposase; Region: OrfB_IS605; pfam01385
449447012205	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012206	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
449447012207	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
449447012208	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
449447012209	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
449447012210	Walker A/P-loop; other site
449447012211	ATP binding site [chemical binding]; other site
449447012212	Q-loop/lid; other site
449447012213	ABC transporter signature motif; other site
449447012214	Walker B; other site
449447012215	D-loop; other site
449447012216	H-loop/switch region; other site
449447012217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447012218	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
449447012219	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
449447012220	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
449447012221	transmembrane helices; other site
449447012222	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
449447012223	Nitrogen regulatory protein P-II; Region: P-II; cl00412
449447012224	Domain of unknown function (DUF897); Region: DUF897; pfam05982
449447012225	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
449447012226	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
449447012227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
449447012228	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
449447012229	FOG: CBS domain [General function prediction only]; Region: COG0517
449447012230	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
449447012231	CP12 domain; Region: CP12; pfam02672
449447012232	Predicted membrane protein [Function unknown]; Region: COG4803
449447012233	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
449447012234	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
449447012235	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
449447012236	acetyl-CoA synthetase; Provisional; Region: PRK00174
449447012237	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
449447012238	active site
449447012239	CoA binding site [chemical binding]; other site
449447012240	acyl-activating enzyme (AAE) consensus motif; other site
449447012241	AMP binding site [chemical binding]; other site
449447012242	acetate binding site [chemical binding]; other site
449447012243	photosystem I subunit VII; Region: psaC; CHL00065
449447012244	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
449447012245	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447012246	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012247	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447012248	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447012249	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447012250	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447012251	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447012252	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012253	putative active site [active]
449447012254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
449447012255	ABC transporter signature motif; other site
449447012256	Walker B; other site
449447012257	D-loop; other site
449447012258	H-loop/switch region; other site
449447012259	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
449447012260	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
449447012261	putative active site [active]
449447012262	putative dimer interface [polypeptide binding]; other site
449447012263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012264	threonine synthase; Reviewed; Region: PRK06721
449447012265	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
449447012266	homodimer interface [polypeptide binding]; other site
449447012267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447012268	catalytic residue [active]
449447012269	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
449447012270	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
449447012271	putative active site pocket [active]
449447012272	4-fold oligomerization interface [polypeptide binding]; other site
449447012273	metal binding residues [ion binding]; metal-binding site
449447012274	3-fold/trimer interface [polypeptide binding]; other site
449447012275	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
449447012276	light-harvesting-like protein 3; Provisional; Region: PLN00014
449447012277	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
449447012278	diaminopimelate epimerase; Region: PLN02536
449447012279	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
449447012280	Sm and related proteins; Region: Sm_like; cl00259
449447012281	heptamer interface [polypeptide binding]; other site
449447012282	Sm1 motif; other site
449447012283	hexamer interface [polypeptide binding]; other site
449447012284	RNA binding site [nucleotide binding]; other site
449447012285	Sm2 motif; other site
449447012286	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
449447012287	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
449447012288	Ligand binding site; other site
449447012289	Putative Catalytic site; other site
449447012290	DXD motif; other site
449447012291	Methyltransferase domain; Region: Methyltransf_23; pfam13489
449447012292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447012293	S-adenosylmethionine binding site [chemical binding]; other site
449447012294	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
449447012295	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447012296	active site
449447012297	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447012298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447012299	S-adenosylmethionine binding site [chemical binding]; other site
449447012300	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
449447012301	active site
449447012302	Clp protease ATP binding subunit; Region: clpC; CHL00095
449447012303	Clp amino terminal domain; Region: Clp_N; pfam02861
449447012304	Clp amino terminal domain; Region: Clp_N; pfam02861
449447012305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012306	Walker A motif; other site
449447012307	ATP binding site [chemical binding]; other site
449447012308	Walker B motif; other site
449447012309	arginine finger; other site
449447012310	UvrB/uvrC motif; Region: UVR; pfam02151
449447012311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012312	Walker A motif; other site
449447012313	ATP binding site [chemical binding]; other site
449447012314	Walker B motif; other site
449447012315	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
449447012316	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
449447012317	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447012318	PRC-barrel domain; Region: PRC; pfam05239
449447012319	PRC-barrel domain; Region: PRC; pfam05239
449447012320	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
449447012321	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
449447012322	E3 interaction surface; other site
449447012323	lipoyl attachment site [posttranslational modification]; other site
449447012324	e3 binding domain; Region: E3_binding; pfam02817
449447012325	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
449447012326	Protein of unknown function (DUF561); Region: DUF561; pfam04481
449447012327	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
449447012328	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
449447012329	Substrate binding site; other site
449447012330	Mg++ binding site; other site
449447012331	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
449447012332	active site
449447012333	substrate binding site [chemical binding]; other site
449447012334	CoA binding site [chemical binding]; other site
449447012335	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
449447012336	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447012337	putative catalytic residue [active]
449447012338	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
449447012339	D-xylulose kinase; Region: XylB; TIGR01312
449447012340	nucleotide binding site [chemical binding]; other site
449447012341	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
449447012342	DsrE/DsrF-like family; Region: DrsE; pfam02635
449447012343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012344	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012345	Probable transposase; Region: OrfB_IS605; pfam01385
449447012346	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012347	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
449447012348	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
449447012349	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
449447012350	Soluble P-type ATPase [General function prediction only]; Region: COG4087
449447012351	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447012352	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
449447012353	cofactor binding site; other site
449447012354	DNA binding site [nucleotide binding]
449447012355	substrate interaction site [chemical binding]; other site
449447012356	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447012357	Transposase; Region: HTH_Tnp_IS630; pfam01710
449447012358	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
449447012359	DNA-binding interface [nucleotide binding]; DNA binding site
449447012360	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
449447012362	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
449447012363	Uncharacterized conserved protein [Function unknown]; Region: COG1434
449447012364	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
449447012365	putative active site [active]
449447012366	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
449447012367	CAP-like domain; other site
449447012368	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
449447012369	active site
449447012370	primary dimer interface [polypeptide binding]; other site
449447012371	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
449447012372	Response regulator receiver domain; Region: Response_reg; pfam00072
449447012373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
449447012374	active site
449447012375	phosphorylation site [posttranslational modification]
449447012376	intermolecular recognition site; other site
449447012377	dimerization interface [polypeptide binding]; other site
449447012378	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
449447012379	hypothetical protein; Provisional; Region: PRK06850
449447012380	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
449447012381	Active Sites [active]
449447012382	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
449447012383	HNH endonuclease; Region: HNH_2; pfam13391
449447012384	classical (c) SDRs; Region: SDR_c; cd05233
449447012385	short chain dehydrogenase; Provisional; Region: PRK07041
449447012386	NAD(P) binding site [chemical binding]; other site
449447012387	active site
449447012388	Methyltransferase domain; Region: Methyltransf_31; pfam13847
449447012389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447012390	S-adenosylmethionine binding site [chemical binding]; other site
449447012391	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
449447012392	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012393	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
449447012394	acyl-activating enzyme (AAE) consensus motif; other site
449447012395	AMP binding site [chemical binding]; other site
449447012396	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012397	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
449447012398	Condensation domain; Region: Condensation; pfam00668
449447012399	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012400	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012401	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012402	acyl-activating enzyme (AAE) consensus motif; other site
449447012403	AMP binding site [chemical binding]; other site
449447012404	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012405	Condensation domain; Region: Condensation; pfam00668
449447012406	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012407	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012408	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012409	acyl-activating enzyme (AAE) consensus motif; other site
449447012410	AMP binding site [chemical binding]; other site
449447012411	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012412	Condensation domain; Region: Condensation; pfam00668
449447012413	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012414	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012415	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012416	acyl-activating enzyme (AAE) consensus motif; other site
449447012417	AMP binding site [chemical binding]; other site
449447012418	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012419	Condensation domain; Region: Condensation; pfam00668
449447012420	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012421	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012422	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012423	acyl-activating enzyme (AAE) consensus motif; other site
449447012424	AMP binding site [chemical binding]; other site
449447012425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
449447012426	S-adenosylmethionine binding site [chemical binding]; other site
449447012427	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
449447012428	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012429	Condensation domain; Region: Condensation; pfam00668
449447012430	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012431	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012432	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012433	acyl-activating enzyme (AAE) consensus motif; other site
449447012434	AMP binding site [chemical binding]; other site
449447012435	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012436	Condensation domain; Region: Condensation; pfam00668
449447012437	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
449447012438	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
449447012439	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
449447012440	acyl-activating enzyme (AAE) consensus motif; other site
449447012441	AMP binding site [chemical binding]; other site
449447012442	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
449447012443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012444	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012445	Probable transposase; Region: OrfB_IS605; pfam01385
449447012446	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012447	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
449447012448	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
449447012449	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
449447012450	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
449447012451	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
449447012452	GUN4-like; Region: GUN4; pfam05419
449447012453	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012454	Homeodomain-like domain; Region: HTH_23; pfam13384
449447012455	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012457	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012458	Probable transposase; Region: OrfB_IS605; pfam01385
449447012459	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
449447012461	Probable transposase; Region: OrfB_IS605; pfam01385
449447012462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012463	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
449447012464	Sulfatase; Region: Sulfatase; pfam00884
449447012465	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
449447012466	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
449447012467	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
449447012468	catalytic residues [active]
449447012469	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
449447012470	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
449447012471	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
449447012472	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
449447012473	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
449447012474	dimer interface [polypeptide binding]; other site
449447012475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
449447012476	catalytic residue [active]
449447012477	Methyltransferase domain; Region: Methyltransf_26; pfam13659
449447012478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012479	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012480	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
449447012481	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447012482	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
449447012483	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
449447012484	dimer interface [polypeptide binding]; other site
449447012485	putative functional site; other site
449447012486	putative MPT binding site; other site
449447012487	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
449447012488	glutaminase; Provisional; Region: PRK00971
449447012489	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
449447012490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012491	binding surface
449447012492	TPR motif; other site
449447012493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012494	binding surface
449447012495	TPR motif; other site
449447012496	TIGR03032 family protein; Region: TIGR03032
449447012497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012498	TPR repeat; Region: TPR_11; pfam13414
449447012499	binding surface
449447012500	DDE superfamily endonuclease; Region: DDE_5; cl17874
449447012501	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012502	Homeodomain-like domain; Region: HTH_23; pfam13384
449447012503	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012504	Homeodomain-like domain; Region: HTH_32; pfam13565
449447012505	Calx-beta domain; Region: Calx-beta; cl02522
449447012506	Calx-beta domain; Region: Calx-beta; cl02522
449447012507	Calx-beta domain; Region: Calx-beta; cl02522
449447012508	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447012509	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447012510	ARD/ARD' family; Region: ARD; pfam03079
449447012511	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
449447012512	Helix-turn-helix domain; Region: HTH_38; pfam13936
449447012513	Homeodomain-like domain; Region: HTH_32; pfam13565
449447012514	Integrase core domain; Region: rve; pfam00665
449447012515	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
449447012516	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
449447012517	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
449447012518	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012519	putative active site [active]
449447012520	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012521	putative active site [active]
449447012522	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012523	putative active site [active]
449447012524	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012525	putative active site [active]
449447012526	Domain of unknown function DUF29; Region: DUF29; pfam01724
449447012527	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
449447012528	catalytic motif [active]
449447012529	Zn binding site [ion binding]; other site
449447012530	heat shock protein HtpX; Provisional; Region: PRK03982
449447012531	cobalt transport protein CbiM; Validated; Region: PRK06265
449447012532	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
449447012533	PDGLE domain; Region: PDGLE; pfam13190
449447012534	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
449447012535	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
449447012536	Walker A/P-loop; other site
449447012537	ATP binding site [chemical binding]; other site
449447012538	Q-loop/lid; other site
449447012539	ABC transporter signature motif; other site
449447012540	Walker B; other site
449447012541	D-loop; other site
449447012542	H-loop/switch region; other site
449447012543	HEAT repeats; Region: HEAT_2; pfam13646
449447012544	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
449447012545	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
449447012546	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
449447012547	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
449447012548	putative active site [active]
449447012549	catalytic site [active]
449447012550	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
449447012551	putative ligand binding site [chemical binding]; other site
449447012552	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447012553	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447012554	structural tetrad; other site
449447012555	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
449447012556	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
449447012557	dimerization interface [polypeptide binding]; other site
449447012558	active site
449447012559	metal binding site [ion binding]; metal-binding site
449447012560	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
449447012561	dsRNA binding site [nucleotide binding]; other site
449447012562	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447012563	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
449447012564	adaptive-response sensory kinase; Validated; Region: PRK09303
449447012565	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
449447012566	tetramer interface [polypeptide binding]; other site
449447012567	dimer interface [polypeptide binding]; other site
449447012568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
449447012569	dimer interface [polypeptide binding]; other site
449447012570	phosphorylation site [posttranslational modification]
449447012571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
449447012572	ATP binding site [chemical binding]; other site
449447012573	Mg2+ binding site [ion binding]; other site
449447012574	G-X-G motif; other site
449447012575	Uncharacterized conserved protein [Function unknown]; Region: COG1543
449447012576	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
449447012577	active site
449447012578	substrate binding site [chemical binding]; other site
449447012579	catalytic site [active]
449447012580	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
449447012581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012582	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012583	Probable transposase; Region: OrfB_IS605; pfam01385
449447012584	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012585	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447012586	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447012587	active site
449447012588	ATP binding site [chemical binding]; other site
449447012589	substrate binding site [chemical binding]; other site
449447012590	activation loop (A-loop); other site
449447012591	Predicted membrane protein [Function unknown]; Region: COG2324
449447012592	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
449447012593	active site
449447012594	AAA ATPase domain; Region: AAA_16; pfam13191
449447012595	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
449447012596	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
449447012597	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
449447012598	catalytic triad [active]
449447012599	Bacterial SH3 domain; Region: SH3_3; pfam08239
449447012600	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
449447012601	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
449447012602	active site
449447012603	metal binding site [ion binding]; metal-binding site
449447012604	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
449447012605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012606	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
449447012607	phosphate acetyltransferase; Reviewed; Region: PRK05632
449447012608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
449447012609	DRTGG domain; Region: DRTGG; pfam07085
449447012610	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
449447012611	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
449447012612	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
449447012613	TrkA-N domain; Region: TrkA_N; pfam02254
449447012614	2TM domain; Region: 2TM; pfam13239
449447012615	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
449447012616	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
449447012617	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
449447012618	hexamer interface [polypeptide binding]; other site
449447012619	ligand binding site [chemical binding]; other site
449447012620	putative active site [active]
449447012621	NAD(P) binding site [chemical binding]; other site
449447012622	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
449447012623	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
449447012624	cofactor binding site; other site
449447012625	DNA binding site [nucleotide binding]
449447012626	substrate interaction site [chemical binding]; other site
449447012627	XisI protein; Region: XisI; pfam08869
449447012628	Calx-beta domain; Region: Calx-beta; cl02522
449447012629	Calx-beta domain; Region: Calx-beta; cl02522
449447012630	Calx-beta domain; Region: Calx-beta; cl02522
449447012631	ARD/ARD' family; Region: ARD; pfam03079
449447012632	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
449447012633	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447012634	putative active site [active]
449447012635	TIGR03032 family protein; Region: TIGR03032
449447012636	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
449447012637	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
449447012638	Chromate transporter; Region: Chromate_transp; pfam02417
449447012639	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
449447012640	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
449447012641	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447012642	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
449447012643	motif II; other site
449447012644	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
449447012645	intersubunit interface [polypeptide binding]; other site
449447012646	active site
449447012647	catalytic residue [active]
449447012648	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
449447012649	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
449447012650	substrate binding site [chemical binding]; other site
449447012651	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
449447012652	substrate binding site [chemical binding]; other site
449447012653	ligand binding site [chemical binding]; other site
449447012654	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
449447012655	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
449447012656	XisI protein; Region: XisI; pfam08869
449447012657	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
449447012658	urease subunit alpha; Reviewed; Region: ureC; PRK13207
449447012659	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
449447012660	subunit interactions [polypeptide binding]; other site
449447012661	active site
449447012662	flap region; other site
449447012663	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
449447012664	CHAT domain; Region: CHAT; cl17868
449447012665	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
449447012666	Transposase [DNA replication, recombination, and repair]; Region: COG5421
449447012667	XisI protein; Region: XisI; pfam08869
449447012668	XisH protein; Region: XisH; pfam08814
449447012669	TIR domain; Region: TIR_2; pfam13676
449447012670	Protein of unknown function (DUF433); Region: DUF433; pfam04255
449447012671	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447012672	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012673	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447012674	Helix-turn-helix domain; Region: HTH_37; pfam13744
449447012675	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
449447012676	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
449447012677	putative active site [active]
449447012678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012679	TPR motif; other site
449447012680	binding surface
449447012681	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
449447012682	Helix-turn-helix domain; Region: HTH_28; pfam13518
449447012683	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012684	Homeodomain-like domain; Region: HTH_32; pfam13565
449447012685	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012686	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
449447012687	trimer interface [polypeptide binding]; other site
449447012688	dimer interface [polypeptide binding]; other site
449447012689	putative active site [active]
449447012690	magnesium chelatase subunit H; Provisional; Region: PLN03241
449447012691	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
449447012692	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
449447012693	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
449447012694	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
449447012695	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
449447012696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
449447012697	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
449447012698	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
449447012699	Acylphosphatase; Region: Acylphosphatase; pfam00708
449447012700	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
449447012701	HypF finger; Region: zf-HYPF; pfam07503
449447012702	HypF finger; Region: zf-HYPF; pfam07503
449447012703	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
449447012704	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
449447012705	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
449447012706	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
449447012707	active site
449447012708	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
449447012709	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
449447012710	substrate binding site [chemical binding]; other site
449447012711	hexamer interface [polypeptide binding]; other site
449447012712	metal binding site [ion binding]; metal-binding site
449447012713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
449447012714	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
449447012715	inhibitor binding site; inhibition site
449447012716	catalytic motif [active]
449447012717	Catalytic residue [active]
449447012718	Active site flap [active]
449447012719	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
449447012720	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447012721	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447012722	active site
449447012723	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
449447012724	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
449447012725	HupF/HypC family; Region: HupF_HypC; cl00394
449447012726	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
449447012727	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
449447012728	TPP-binding site [chemical binding]; other site
449447012729	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
449447012730	PYR/PP interface [polypeptide binding]; other site
449447012731	dimer interface [polypeptide binding]; other site
449447012732	TPP binding site [chemical binding]; other site
449447012733	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447012734	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
449447012735	Clp amino terminal domain; Region: Clp_N; pfam02861
449447012736	Clp amino terminal domain; Region: Clp_N; pfam02861
449447012737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012738	Walker A motif; other site
449447012739	ATP binding site [chemical binding]; other site
449447012740	Walker B motif; other site
449447012741	arginine finger; other site
449447012742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012743	Walker A motif; other site
449447012744	ATP binding site [chemical binding]; other site
449447012745	Walker B motif; other site
449447012746	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
449447012747	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012748	putative active site [active]
449447012749	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
449447012750	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
449447012751	TM-ABC transporter signature motif; other site
449447012752	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
449447012753	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
449447012754	Protein of unknown function (DUF721); Region: DUF721; cl02324
449447012755	phage shock protein A; Region: phageshock_pspA; TIGR02977
449447012756	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447012757	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447012758	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
449447012759	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
449447012760	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
449447012761	ligand binding site [chemical binding]; other site
449447012762	homodimer interface [polypeptide binding]; other site
449447012763	NAD(P) binding site [chemical binding]; other site
449447012764	trimer interface B [polypeptide binding]; other site
449447012765	trimer interface A [polypeptide binding]; other site
449447012766	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
449447012767	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
449447012768	multifunctional aminopeptidase A; Provisional; Region: PRK00913
449447012769	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
449447012770	interface (dimer of trimers) [polypeptide binding]; other site
449447012771	Substrate-binding/catalytic site; other site
449447012772	Zn-binding sites [ion binding]; other site
449447012773	Probable transposase; Region: OrfB_IS605; pfam01385
449447012774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012776	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012777	TPR repeat; Region: TPR_11; pfam13414
449447012778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012779	binding surface
449447012780	TPR motif; other site
449447012781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447012782	binding surface
449447012783	TPR repeat; Region: TPR_11; pfam13414
449447012784	TPR motif; other site
449447012785	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
449447012786	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
449447012787	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
449447012788	putative active site [active]
449447012789	putative NTP binding site [chemical binding]; other site
449447012790	putative nucleic acid binding site [nucleotide binding]; other site
449447012791	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
449447012792	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
449447012793	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
449447012794	active site
449447012795	FtsH Extracellular; Region: FtsH_ext; pfam06480
449447012796	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
449447012797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012798	Walker A motif; other site
449447012799	ATP binding site [chemical binding]; other site
449447012800	Walker B motif; other site
449447012801	arginine finger; other site
449447012802	Peptidase family M41; Region: Peptidase_M41; pfam01434
449447012803	Transcriptional regulator [Transcription]; Region: LysR; COG0583
449447012804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
449447012805	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
449447012806	putative dimerization interface [polypeptide binding]; other site
449447012807	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
449447012808	Predicted permease [General function prediction only]; Region: COG3329
449447012809	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
449447012810	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
449447012811	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
449447012812	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
449447012813	Uncharacterized conserved protein [Function unknown]; Region: COG2968
449447012814	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
449447012815	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
449447012818	Transposase; Region: DDE_Tnp_ISL3; pfam01610
449447012819	ZPR1 zinc-finger domain; Region: zf-ZPR1; pfam03367
449447012820	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
449447012821	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
449447012822	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012823	putative active site [active]
449447012824	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
449447012825	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
449447012826	hinge; other site
449447012827	active site
449447012828	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
449447012829	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
449447012830	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
449447012831	Homeodomain-like domain; Region: HTH_23; pfam13384
449447012832	Winged helix-turn helix; Region: HTH_29; pfam13551
449447012833	Homeodomain-like domain; Region: HTH_32; pfam13565
449447012834	DDE superfamily endonuclease; Region: DDE_3; pfam13358
449447012835	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
449447012836	AAA domain; Region: AAA_33; pfam13671
449447012837	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
449447012838	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
449447012839	purine monophosphate binding site [chemical binding]; other site
449447012840	dimer interface [polypeptide binding]; other site
449447012841	putative catalytic residues [active]
449447012842	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
449447012843	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
449447012844	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447012845	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012846	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447012847	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
449447012848	putative active site [active]
449447012849	PemK-like protein; Region: PemK; pfam02452
449447012850	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
449447012851	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
449447012852	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
449447012853	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
449447012854	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
449447012855	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
449447012856	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
449447012857	NAD binding site [chemical binding]; other site
449447012858	homodimer interface [polypeptide binding]; other site
449447012859	active site
449447012860	substrate binding site [chemical binding]; other site
449447012861	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
449447012862	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
449447012863	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
449447012864	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
449447012865	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
449447012866	active site
449447012867	substrate binding site [chemical binding]; other site
449447012868	cosubstrate binding site; other site
449447012869	catalytic site [active]
449447012870	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012871	putative active site [active]
449447012872	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
449447012873	putative active site [active]
449447012874	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
449447012875	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
449447012876	HIGH motif; other site
449447012877	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
449447012878	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
449447012879	active site
449447012880	KMSKS motif; other site
449447012881	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
449447012882	tRNA binding surface [nucleotide binding]; other site
449447012883	anticodon binding site; other site
449447012884	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
449447012885	isocitrate dehydrogenase; Validated; Region: PRK07362
449447012886	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
449447012887	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
449447012888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
449447012889	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
449447012890	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447012891	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
449447012892	active site
449447012893	substrate binding site [chemical binding]; other site
449447012894	ATP binding site [chemical binding]; other site
449447012895	activation loop (A-loop); other site
449447012896	FOG: WD40 repeat [General function prediction only]; Region: COG2319
449447012897	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
449447012898	structural tetrad; other site
449447012899	PQQ-like domain; Region: PQQ_2; pfam13360
449447012900	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
449447012901	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
449447012902	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
449447012903	oligomeric interface; other site
449447012904	putative active site [active]
449447012905	homodimer interface [polypeptide binding]; other site
449447012906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012907	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447012908	Probable transposase; Region: OrfB_IS605; pfam01385
449447012909	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012910	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
449447012911	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
449447012912	TPP-binding site; other site
449447012913	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
449447012914	PYR/PP interface [polypeptide binding]; other site
449447012915	dimer interface [polypeptide binding]; other site
449447012916	TPP binding site [chemical binding]; other site
449447012917	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
449447012918	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
449447012919	AIR carboxylase; Region: AIRC; smart01001
449447012920	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
449447012921	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
449447012922	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
449447012923	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
449447012924	dihydrodipicolinate synthase; Region: dapA; TIGR00674
449447012925	dimer interface [polypeptide binding]; other site
449447012926	active site
449447012927	catalytic residue [active]
449447012928	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
449447012929	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
449447012930	trigger factor; Provisional; Region: tig; PRK01490
449447012931	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
449447012932	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
449447012933	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
449447012934	Clp protease; Region: CLP_protease; pfam00574
449447012935	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
449447012936	oligomer interface [polypeptide binding]; other site
449447012937	active site residues [active]
449447012938	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
449447012939	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
449447012940	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
449447012941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
449447012942	Walker A motif; other site
449447012943	ATP binding site [chemical binding]; other site
449447012944	Walker B motif; other site
449447012945	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
449447012946	PemK-like protein; Region: PemK; pfam02452
449447012947	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
449447012948	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
449447012949	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
449447012950	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
449447012951	catalytic triad [active]
449447012952	dimer interface [polypeptide binding]; other site
449447012953	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
449447012954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447012955	Probable transposase; Region: OrfB_IS605; pfam01385
449447012956	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447012957	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
449447012958	YcfA-like protein; Region: YcfA; pfam07927
449447012959	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
449447012960	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
449447012961	dimerization interface [polypeptide binding]; other site
449447012962	DPS ferroxidase diiron center [ion binding]; other site
449447012963	ion pore; other site
449447012964	Catalytic domain of Protein Kinases; Region: PKc; cd00180
449447012965	active site
449447012966	ATP binding site [chemical binding]; other site
449447012967	substrate binding site [chemical binding]; other site
449447012968	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
449447012969	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
449447012970	DDE superfamily endonuclease; Region: DDE_4; pfam13359
449447012971	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
449447012972	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
449447012973	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
449447012974	Dynamin family; Region: Dynamin_N; pfam00350
449447012975	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
449447012976	G1 box; other site
449447012977	GTP/Mg2+ binding site [chemical binding]; other site
449447012978	Switch I region; other site
449447012979	G2 box; other site
449447012980	Switch II region; other site
449447012981	G3 box; other site
449447012982	G4 box; other site
449447012983	G5 box; other site
449447012984	Domain of unknown function (DUF697); Region: DUF697; pfam05128
449447012985	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
449447012986	Bacitracin resistance protein BacA; Region: BacA; cl00858
449447012987	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
449447012988	putative switch regulator; other site
449447012989	non-specific DNA interactions [nucleotide binding]; other site
449447012990	DNA binding site [nucleotide binding]
449447012991	sequence specific DNA binding site [nucleotide binding]; other site
449447012992	putative cAMP binding site [chemical binding]; other site
449447012993	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
449447012994	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
449447012995	DNA binding residues [nucleotide binding]
449447012996	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
449447012997	catalytic residues [active]
449447012998	catalytic nucleophile [active]
449447012999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447013000	Probable transposase; Region: OrfB_IS605; pfam01385
449447013001	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447013002	coproporphyrinogen III oxidase; Provisional; Region: PRK08629
449447013003	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
449447013004	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
449447013005	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
449447013006	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
449447013007	Walker A/P-loop; other site
449447013008	ATP binding site [chemical binding]; other site
449447013009	Q-loop/lid; other site
449447013010	ABC transporter signature motif; other site
449447013011	Walker B; other site
449447013012	D-loop; other site
449447013013	H-loop/switch region; other site
449447013014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
449447013015	TPR motif; other site
449447013016	TPR repeat; Region: TPR_11; pfam13414
449447013017	binding surface
449447013018	Transposase IS200 like; Region: Y1_Tnp; cl00848
449447013019	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
449447013020	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
449447013021	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
449447013022	Transposase IS200 like; Region: Y1_Tnp; pfam01797
449447013023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
449447013024	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
449447013025	Probable transposase; Region: OrfB_IS605; pfam01385
449447013026	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
449447013027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
449447013028	NADH(P)-binding; Region: NAD_binding_10; pfam13460
449447013029	NAD(P) binding site [chemical binding]; other site
449447013030	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
449447013031	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
449447013032	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
449447013033	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
449447013034	motif II; other site
449447013035	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242