-- dump date 20140619_145930 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1032480000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1032480000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480000003 Walker A motif; other site 1032480000004 ATP binding site [chemical binding]; other site 1032480000005 Walker B motif; other site 1032480000006 arginine finger; other site 1032480000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1032480000008 DnaA box-binding interface [nucleotide binding]; other site 1032480000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1032480000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1032480000011 putative DNA binding surface [nucleotide binding]; other site 1032480000012 dimer interface [polypeptide binding]; other site 1032480000013 beta-clamp/clamp loader binding surface; other site 1032480000014 beta-clamp/translesion DNA polymerase binding surface; other site 1032480000015 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1032480000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1032480000017 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480000018 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480000019 phosphopeptide binding site; other site 1032480000020 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480000021 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480000022 phosphopeptide binding site; other site 1032480000023 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480000024 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1032480000025 Walker A/P-loop; other site 1032480000026 ATP binding site [chemical binding]; other site 1032480000027 Q-loop/lid; other site 1032480000028 ABC transporter signature motif; other site 1032480000029 Walker B; other site 1032480000030 D-loop; other site 1032480000031 H-loop/switch region; other site 1032480000032 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1032480000033 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1032480000034 Protein of unknown function (DUF721); Region: DUF721; cl02324 1032480000035 recombination protein F; Reviewed; Region: recF; PRK00064 1032480000036 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1032480000037 Walker A/P-loop; other site 1032480000038 ATP binding site [chemical binding]; other site 1032480000039 Q-loop/lid; other site 1032480000040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000041 ABC transporter signature motif; other site 1032480000042 Walker B; other site 1032480000043 D-loop; other site 1032480000044 H-loop/switch region; other site 1032480000045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480000046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480000047 active site 1032480000048 ATP binding site [chemical binding]; other site 1032480000049 substrate binding site [chemical binding]; other site 1032480000050 activation loop (A-loop); other site 1032480000051 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1032480000052 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1032480000053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000054 Mg2+ binding site [ion binding]; other site 1032480000055 G-X-G motif; other site 1032480000056 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1032480000057 anchoring element; other site 1032480000058 dimer interface [polypeptide binding]; other site 1032480000059 ATP binding site [chemical binding]; other site 1032480000060 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1032480000061 active site 1032480000062 putative metal-binding site [ion binding]; other site 1032480000063 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1032480000064 DNA gyrase subunit A; Validated; Region: PRK05560 1032480000065 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1032480000066 CAP-like domain; other site 1032480000067 active site 1032480000068 primary dimer interface [polypeptide binding]; other site 1032480000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480000072 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1032480000073 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1032480000074 ApbE family; Region: ApbE; pfam02424 1032480000075 FMN-binding domain; Region: FMN_bind; cl01081 1032480000076 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1032480000077 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1032480000078 FAD binding pocket [chemical binding]; other site 1032480000079 conserved FAD binding motif [chemical binding]; other site 1032480000080 phosphate binding motif [ion binding]; other site 1032480000081 beta-alpha-beta structure motif; other site 1032480000082 NAD binding pocket [chemical binding]; other site 1032480000083 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1032480000084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000085 active site 1032480000086 phosphorylation site [posttranslational modification] 1032480000087 intermolecular recognition site; other site 1032480000088 dimerization interface [polypeptide binding]; other site 1032480000089 DNA binding site [nucleotide binding] 1032480000090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1032480000091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480000092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000093 dimer interface [polypeptide binding]; other site 1032480000094 phosphorylation site [posttranslational modification] 1032480000095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000096 ATP binding site [chemical binding]; other site 1032480000097 Mg2+ binding site [ion binding]; other site 1032480000098 G-X-G motif; other site 1032480000099 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480000100 AAA domain; Region: AAA_14; pfam13173 1032480000101 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480000102 short chain dehydrogenase; Provisional; Region: PRK06197 1032480000103 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480000104 putative NAD(P) binding site [chemical binding]; other site 1032480000105 active site 1032480000106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480000107 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480000108 potential frameshift: common BLAST hit: gi|302865121|ref|YP_003833758.1| helix-turn-helix domain-containing protein 1032480000109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480000110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480000111 salt bridge; other site 1032480000112 non-specific DNA binding site [nucleotide binding]; other site 1032480000113 sequence-specific DNA binding site [nucleotide binding]; other site 1032480000114 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480000115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480000116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480000117 dimerization interface [polypeptide binding]; other site 1032480000118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000119 dimer interface [polypeptide binding]; other site 1032480000120 phosphorylation site [posttranslational modification] 1032480000121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000122 ATP binding site [chemical binding]; other site 1032480000123 Mg2+ binding site [ion binding]; other site 1032480000124 G-X-G motif; other site 1032480000125 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000127 active site 1032480000128 phosphorylation site [posttranslational modification] 1032480000129 intermolecular recognition site; other site 1032480000130 dimerization interface [polypeptide binding]; other site 1032480000131 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000132 DNA binding site [nucleotide binding] 1032480000133 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1032480000134 VanZ like family; Region: VanZ; cl01971 1032480000135 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480000136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480000137 DNA binding residues [nucleotide binding] 1032480000138 YCII-related domain; Region: YCII; cl00999 1032480000139 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480000140 homodimer interface [polypeptide binding]; other site 1032480000141 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480000142 active site 1032480000143 TDP-binding site; other site 1032480000144 acceptor substrate-binding pocket; other site 1032480000145 Phospholipid methyltransferase; Region: PEMT; cl17370 1032480000146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480000147 dimerization interface [polypeptide binding]; other site 1032480000148 putative DNA binding site [nucleotide binding]; other site 1032480000149 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480000150 putative Zn2+ binding site [ion binding]; other site 1032480000151 potential frameshift: common BLAST hit: gi|300790366|ref|YP_003770657.1| major facilitator transporter 1032480000152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000153 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000156 active site 1032480000157 phosphorylation site [posttranslational modification] 1032480000158 intermolecular recognition site; other site 1032480000159 dimerization interface [polypeptide binding]; other site 1032480000160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000161 DNA binding residues [nucleotide binding] 1032480000162 dimerization interface [polypeptide binding]; other site 1032480000163 Histidine kinase; Region: HisKA_3; pfam07730 1032480000164 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480000165 ATP binding site [chemical binding]; other site 1032480000166 Mg2+ binding site [ion binding]; other site 1032480000167 G-X-G motif; other site 1032480000168 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480000169 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480000170 Walker A/P-loop; other site 1032480000171 ATP binding site [chemical binding]; other site 1032480000172 Q-loop/lid; other site 1032480000173 ABC transporter signature motif; other site 1032480000174 Walker B; other site 1032480000175 D-loop; other site 1032480000176 H-loop/switch region; other site 1032480000177 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1032480000178 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480000179 active site 1032480000180 HIGH motif; other site 1032480000181 nucleotide binding site [chemical binding]; other site 1032480000182 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1032480000183 active site 1032480000184 KMSKS motif; other site 1032480000185 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1032480000186 tRNA binding surface [nucleotide binding]; other site 1032480000187 anticodon binding site; other site 1032480000188 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1032480000189 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480000190 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480000191 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480000192 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480000193 AAA ATPase domain; Region: AAA_16; pfam13191 1032480000194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000195 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000196 DNA binding residues [nucleotide binding] 1032480000197 dimerization interface [polypeptide binding]; other site 1032480000198 CHAD domain; Region: CHAD; pfam05235 1032480000199 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480000200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000201 P-loop; other site 1032480000202 Magnesium ion binding site [ion binding]; other site 1032480000203 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000204 Magnesium ion binding site [ion binding]; other site 1032480000205 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1032480000206 active site clefts [active] 1032480000207 zinc binding site [ion binding]; other site 1032480000208 dimer interface [polypeptide binding]; other site 1032480000209 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1032480000210 active site 1032480000211 catalytic residues [active] 1032480000212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000214 TPR motif; other site 1032480000215 binding surface 1032480000216 CHAT domain; Region: CHAT; pfam12770 1032480000217 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480000218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480000219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480000220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000221 S-adenosylmethionine binding site [chemical binding]; other site 1032480000222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 1032480000223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000224 AAA domain; Region: AAA_23; pfam13476 1032480000225 Walker A/P-loop; other site 1032480000226 ATP binding site [chemical binding]; other site 1032480000227 Q-loop/lid; other site 1032480000228 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1032480000229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000230 ABC transporter signature motif; other site 1032480000231 Walker B; other site 1032480000232 D-loop; other site 1032480000233 H-loop/switch region; other site 1032480000234 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1032480000235 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1032480000236 active site 1032480000237 metal binding site [ion binding]; metal-binding site 1032480000238 DNA binding site [nucleotide binding] 1032480000239 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1032480000240 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1032480000241 AAA domain; Region: AAA_14; pfam13173 1032480000242 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480000243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000245 active site 1032480000246 phosphorylation site [posttranslational modification] 1032480000247 intermolecular recognition site; other site 1032480000248 dimerization interface [polypeptide binding]; other site 1032480000249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000250 DNA binding residues [nucleotide binding] 1032480000251 dimerization interface [polypeptide binding]; other site 1032480000252 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480000253 ATP binding site [chemical binding]; other site 1032480000254 Mg2+ binding site [ion binding]; other site 1032480000255 G-X-G motif; other site 1032480000256 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480000257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000258 active site 1032480000259 phosphorylation site [posttranslational modification] 1032480000260 intermolecular recognition site; other site 1032480000261 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1032480000262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480000263 Histidine kinase; Region: HisKA_3; pfam07730 1032480000264 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480000265 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480000266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480000268 active site 1032480000269 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1032480000270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480000271 DNA binding residues [nucleotide binding] 1032480000272 putative dimer interface [polypeptide binding]; other site 1032480000273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000274 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1032480000275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1032480000276 putative dimer interface [polypeptide binding]; other site 1032480000277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480000279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480000280 non-specific DNA binding site [nucleotide binding]; other site 1032480000281 salt bridge; other site 1032480000282 sequence-specific DNA binding site [nucleotide binding]; other site 1032480000283 Predicted ATPase [General function prediction only]; Region: COG3903 1032480000284 Hemerythrin-like domain; Region: Hr-like; cd12108 1032480000285 Fe binding site [ion binding]; other site 1032480000286 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480000287 Moco binding site; other site 1032480000288 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1032480000289 beta-galactosidase; Region: BGL; TIGR03356 1032480000290 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480000291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480000292 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480000293 DNA binding residues [nucleotide binding] 1032480000294 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1032480000295 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1032480000296 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1032480000297 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480000298 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1032480000299 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480000300 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480000301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480000302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000304 binding surface 1032480000305 TPR motif; other site 1032480000306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000309 binding surface 1032480000310 TPR motif; other site 1032480000311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000313 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1032480000314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000315 TPR motif; other site 1032480000316 binding surface 1032480000317 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480000320 binding surface 1032480000321 TPR motif; other site 1032480000322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480000323 Helix-turn-helix domain; Region: HTH_38; pfam13936 1032480000324 DNA-binding interface [nucleotide binding]; DNA binding site 1032480000325 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480000326 Integrase core domain; Region: rve; pfam00665 1032480000327 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1032480000328 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1032480000329 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480000330 active site 1032480000331 Protein of unknown function (DUF555); Region: DUF555; cl00818 1032480000332 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1032480000333 Transglycosylase; Region: Transgly; pfam00912 1032480000334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1032480000335 Predicted integral membrane protein [Function unknown]; Region: COG5650 1032480000336 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1032480000337 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1032480000338 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1032480000339 active site 1032480000340 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1032480000341 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 1032480000342 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480000343 catalytic residue [active] 1032480000344 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1032480000345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1032480000346 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1032480000347 EamA-like transporter family; Region: EamA; pfam00892 1032480000348 EamA-like transporter family; Region: EamA; pfam00892 1032480000349 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1032480000350 putative active site [active] 1032480000351 putative catalytic site [active] 1032480000352 putative DNA binding site [nucleotide binding]; other site 1032480000353 putative phosphate binding site [ion binding]; other site 1032480000354 metal binding site A [ion binding]; metal-binding site 1032480000355 putative AP binding site [nucleotide binding]; other site 1032480000356 putative metal binding site B [ion binding]; other site 1032480000357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480000358 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480000359 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480000360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480000361 putative acyl-acceptor binding pocket; other site 1032480000362 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1032480000363 classical (c) SDRs; Region: SDR_c; cd05233 1032480000364 NAD(P) binding site [chemical binding]; other site 1032480000365 active site 1032480000366 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1032480000367 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1032480000368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480000369 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1032480000370 putative NAD(P) binding site [chemical binding]; other site 1032480000371 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1032480000372 active site 1032480000373 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480000374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480000375 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1032480000376 RibD C-terminal domain; Region: RibD_C; cl17279 1032480000377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480000378 Transposase; Region: HTH_Tnp_1; cl17663 1032480000379 putative transposase OrfB; Reviewed; Region: PHA02517 1032480000380 HTH-like domain; Region: HTH_21; pfam13276 1032480000381 Integrase core domain; Region: rve; pfam00665 1032480000382 Integrase core domain; Region: rve_3; pfam13683 1032480000383 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1032480000384 dimerization interface [polypeptide binding]; other site 1032480000385 active site 1032480000386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480000387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000388 propionate/acetate kinase; Provisional; Region: PRK12379 1032480000389 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1032480000390 phosphate acetyltransferase; Reviewed; Region: PRK05632 1032480000391 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480000392 DRTGG domain; Region: DRTGG; pfam07085 1032480000393 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1032480000394 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480000395 Restriction endonuclease; Region: Mrr_cat; pfam04471 1032480000396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000398 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480000399 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1032480000400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1032480000401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1032480000402 AAA domain; Region: AAA_17; pfam13207 1032480000403 AAA domain; Region: AAA_33; pfam13671 1032480000404 PAAR motif; Region: PAAR_motif; pfam05488 1032480000405 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1032480000406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000408 active site 1032480000409 phosphorylation site [posttranslational modification] 1032480000410 intermolecular recognition site; other site 1032480000411 dimerization interface [polypeptide binding]; other site 1032480000412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000413 DNA binding residues [nucleotide binding] 1032480000414 dimerization interface [polypeptide binding]; other site 1032480000415 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480000416 ATP binding site [chemical binding]; other site 1032480000417 Mg2+ binding site [ion binding]; other site 1032480000418 G-X-G motif; other site 1032480000419 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1032480000420 Walker A motif; other site 1032480000421 ATP binding site [chemical binding]; other site 1032480000422 MULE transposase domain; Region: MULE; pfam10551 1032480000423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480000424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000425 dimer interface [polypeptide binding]; other site 1032480000426 conserved gate region; other site 1032480000427 putative PBP binding loops; other site 1032480000428 ABC-ATPase subunit interface; other site 1032480000429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000430 dimer interface [polypeptide binding]; other site 1032480000431 conserved gate region; other site 1032480000432 putative PBP binding loops; other site 1032480000433 ABC-ATPase subunit interface; other site 1032480000434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480000435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480000436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480000440 S-adenosylmethionine binding site [chemical binding]; other site 1032480000441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000443 RibD C-terminal domain; Region: RibD_C; cl17279 1032480000444 MULE transposase domain; Region: MULE; pfam10551 1032480000445 Integrase core domain; Region: rve; pfam00665 1032480000446 Helix-turn-helix domain; Region: HTH_38; pfam13936 1032480000447 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480000448 Integrase core domain; Region: rve; pfam00665 1032480000449 HTH-like domain; Region: HTH_21; pfam13276 1032480000450 Integrase core domain; Region: rve; pfam00665 1032480000451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480000452 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480000453 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480000454 P-loop; other site 1032480000455 Magnesium ion binding site [ion binding]; other site 1032480000456 AAA domain; Region: AAA_31; pfam13614 1032480000457 Histidine kinase; Region: HisKA_3; pfam07730 1032480000458 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1032480000459 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480000460 putative active site [active] 1032480000461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480000462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000463 DNA binding site [nucleotide binding] 1032480000464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480000465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480000466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000468 DNA binding site [nucleotide binding] 1032480000469 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000470 ligand binding site [chemical binding]; other site 1032480000471 dimerization interface [polypeptide binding]; other site 1032480000472 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480000473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480000474 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1032480000475 DXD motif; other site 1032480000476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000477 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480000478 active site 1032480000479 phosphorylation site [posttranslational modification] 1032480000480 intermolecular recognition site; other site 1032480000481 dimerization interface [polypeptide binding]; other site 1032480000482 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1032480000483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000484 putative transporter; Provisional; Region: PRK10504 1032480000485 putative substrate translocation pore; other site 1032480000486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000487 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1032480000488 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1032480000489 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480000490 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1032480000491 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480000492 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480000493 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480000494 putative catalytic site [active] 1032480000495 putative metal binding site [ion binding]; other site 1032480000496 putative phosphate binding site [ion binding]; other site 1032480000497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000499 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000500 dimerization interface [polypeptide binding]; other site 1032480000501 ligand binding site [chemical binding]; other site 1032480000502 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480000503 putative hydrophobic ligand binding site [chemical binding]; other site 1032480000504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000505 putative substrate translocation pore; other site 1032480000506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480000507 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480000508 Ligand Binding Site [chemical binding]; other site 1032480000509 sucrose phosphorylase; Provisional; Region: PRK13840 1032480000510 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1032480000511 active site 1032480000512 homodimer interface [polypeptide binding]; other site 1032480000513 catalytic site [active] 1032480000514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480000515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480000516 DNA binding site [nucleotide binding] 1032480000517 domain linker motif; other site 1032480000518 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480000519 dimerization interface [polypeptide binding]; other site 1032480000520 ligand binding site [chemical binding]; other site 1032480000521 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1032480000522 ACT domain; Region: ACT_6; pfam13740 1032480000523 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1032480000524 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1032480000525 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1032480000526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480000527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480000528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480000529 dimerization interface [polypeptide binding]; other site 1032480000530 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1032480000531 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1032480000532 putative active site [active] 1032480000533 metal binding site [ion binding]; metal-binding site 1032480000534 Clp protease ATP binding subunit; Region: clpC; CHL00095 1032480000535 hypothetical protein; Provisional; Region: PRK11239 1032480000536 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1032480000537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000539 S-adenosylmethionine binding site [chemical binding]; other site 1032480000540 Dienelactone hydrolase family; Region: DLH; pfam01738 1032480000541 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480000542 Associated with zinc fingers; Region: PRE_C2HC; cl11655 1032480000543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480000544 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480000545 ATP binding site [chemical binding]; other site 1032480000546 substrate binding site [chemical binding]; other site 1032480000547 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1032480000548 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1032480000549 NAD binding site [chemical binding]; other site 1032480000550 sugar binding site [chemical binding]; other site 1032480000551 divalent metal binding site [ion binding]; other site 1032480000552 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480000553 dimer interface [polypeptide binding]; other site 1032480000554 TPR repeat; Region: TPR_11; pfam13414 1032480000555 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1032480000556 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1032480000557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1032480000558 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1032480000559 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480000560 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1032480000561 putative active site [active] 1032480000562 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480000563 active site 1032480000564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1032480000565 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1032480000566 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480000567 Short C-terminal domain; Region: SHOCT; pfam09851 1032480000568 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480000569 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1032480000570 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1032480000571 putative catalytic site [active] 1032480000572 putative phosphate binding site [ion binding]; other site 1032480000573 active site 1032480000574 metal binding site A [ion binding]; metal-binding site 1032480000575 DNA binding site [nucleotide binding] 1032480000576 putative AP binding site [nucleotide binding]; other site 1032480000577 putative metal binding site B [ion binding]; other site 1032480000578 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000580 putative substrate translocation pore; other site 1032480000581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480000582 putative DNA binding site [nucleotide binding]; other site 1032480000583 dimerization interface [polypeptide binding]; other site 1032480000584 putative Zn2+ binding site [ion binding]; other site 1032480000585 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1032480000586 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1032480000587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000588 DNA-binding site [nucleotide binding]; DNA binding site 1032480000589 FCD domain; Region: FCD; pfam07729 1032480000590 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480000591 Proline racemase; Region: Pro_racemase; pfam05544 1032480000592 ornithine cyclodeaminase; Validated; Region: PRK08618 1032480000593 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1032480000594 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480000595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000596 DNA-binding site [nucleotide binding]; DNA binding site 1032480000597 UTRA domain; Region: UTRA; pfam07702 1032480000598 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1032480000599 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1032480000600 active site 1032480000601 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480000602 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1032480000603 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1032480000604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000605 dimer interface [polypeptide binding]; other site 1032480000606 conserved gate region; other site 1032480000607 putative PBP binding loops; other site 1032480000608 ABC-ATPase subunit interface; other site 1032480000609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480000610 dimer interface [polypeptide binding]; other site 1032480000611 conserved gate region; other site 1032480000612 putative PBP binding loops; other site 1032480000613 ABC-ATPase subunit interface; other site 1032480000614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000615 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1032480000616 ABC transporter signature motif; other site 1032480000617 Walker B; other site 1032480000618 D-loop; other site 1032480000619 H-loop/switch region; other site 1032480000620 TOBE domain; Region: TOBE_2; pfam08402 1032480000621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000622 Walker A/P-loop; other site 1032480000623 ATP binding site [chemical binding]; other site 1032480000624 Q-loop/lid; other site 1032480000625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480000626 non-specific DNA binding site [nucleotide binding]; other site 1032480000627 salt bridge; other site 1032480000628 sequence-specific DNA binding site [nucleotide binding]; other site 1032480000629 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1032480000630 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1032480000631 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480000632 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480000633 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1032480000634 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1032480000635 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1032480000636 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1032480000637 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1032480000638 ligand binding site [chemical binding]; other site 1032480000639 homodimer interface [polypeptide binding]; other site 1032480000640 NAD(P) binding site [chemical binding]; other site 1032480000641 trimer interface B [polypeptide binding]; other site 1032480000642 trimer interface A [polypeptide binding]; other site 1032480000643 BNR repeat-like domain; Region: BNR_2; pfam13088 1032480000644 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1032480000645 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480000646 Moco binding site; other site 1032480000647 metal coordination site [ion binding]; other site 1032480000648 threonine dehydratase; Validated; Region: PRK08639 1032480000649 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1032480000650 tetramer interface [polypeptide binding]; other site 1032480000651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480000652 catalytic residue [active] 1032480000653 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1032480000654 putative Ile/Val binding site [chemical binding]; other site 1032480000655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480000657 DNA binding residues [nucleotide binding] 1032480000658 dimerization interface [polypeptide binding]; other site 1032480000659 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000661 active site 1032480000662 phosphorylation site [posttranslational modification] 1032480000663 intermolecular recognition site; other site 1032480000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000665 ATP binding site [chemical binding]; other site 1032480000666 Mg2+ binding site [ion binding]; other site 1032480000667 G-X-G motif; other site 1032480000668 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1032480000669 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1032480000670 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1032480000671 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480000672 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1032480000673 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1032480000674 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480000675 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1032480000676 Walker A/P-loop; other site 1032480000677 ATP binding site [chemical binding]; other site 1032480000678 Q-loop/lid; other site 1032480000679 ABC transporter signature motif; other site 1032480000680 Walker B; other site 1032480000681 D-loop; other site 1032480000682 H-loop/switch region; other site 1032480000683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480000685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000686 Walker A/P-loop; other site 1032480000687 ATP binding site [chemical binding]; other site 1032480000688 Q-loop/lid; other site 1032480000689 ABC transporter signature motif; other site 1032480000690 Walker B; other site 1032480000691 D-loop; other site 1032480000692 H-loop/switch region; other site 1032480000693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000695 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1032480000696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000697 S-adenosylmethionine binding site [chemical binding]; other site 1032480000698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480000699 putative phosphatase; Provisional; Region: PRK11587 1032480000700 active site 1032480000701 motif I; other site 1032480000702 motif II; other site 1032480000703 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1032480000704 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1032480000705 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1032480000706 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1032480000707 dimer interface [polypeptide binding]; other site 1032480000708 active site 1032480000709 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480000710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480000711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480000712 Walker A/P-loop; other site 1032480000713 ATP binding site [chemical binding]; other site 1032480000714 Q-loop/lid; other site 1032480000715 ABC transporter signature motif; other site 1032480000716 Walker B; other site 1032480000717 D-loop; other site 1032480000718 H-loop/switch region; other site 1032480000719 FtsX-like permease family; Region: FtsX; pfam02687 1032480000720 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480000721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000722 putative substrate translocation pore; other site 1032480000723 Thioesterase domain; Region: Thioesterase; pfam00975 1032480000724 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1032480000725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480000726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480000727 catalytic residue [active] 1032480000728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480000729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000730 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000731 active site 1032480000732 Condensation domain; Region: Condensation; pfam00668 1032480000733 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1032480000734 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1032480000735 acyl-activating enzyme (AAE) consensus motif; other site 1032480000736 AMP binding site [chemical binding]; other site 1032480000737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480000738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000739 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000740 active site 1032480000741 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1032480000742 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1032480000743 Condensation domain; Region: Condensation; pfam00668 1032480000744 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1032480000745 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1032480000746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1032480000747 acyl-activating enzyme (AAE) consensus motif; other site 1032480000748 AMP binding site [chemical binding]; other site 1032480000749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480000750 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1032480000751 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1032480000752 active site 1032480000753 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480000754 Condensation domain; Region: Condensation; pfam00668 1032480000755 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1032480000756 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1032480000757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480000758 acyl-activating enzyme (AAE) consensus motif; other site 1032480000759 AMP binding site [chemical binding]; other site 1032480000760 active site 1032480000761 CoA binding site [chemical binding]; other site 1032480000762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480000763 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1032480000764 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1032480000765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000767 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1032480000768 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480000769 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1032480000770 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480000771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1032480000772 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1032480000773 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1032480000774 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1032480000775 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1032480000776 dimer interface [polypeptide binding]; other site 1032480000777 putative anticodon binding site; other site 1032480000778 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1032480000779 motif 1; other site 1032480000780 dimer interface [polypeptide binding]; other site 1032480000781 active site 1032480000782 motif 2; other site 1032480000783 motif 3; other site 1032480000784 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480000785 MarR family; Region: MarR_2; pfam12802 1032480000786 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480000787 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1032480000788 conserved cys residue [active] 1032480000789 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1032480000790 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480000791 putative NAD(P) binding site [chemical binding]; other site 1032480000792 catalytic Zn binding site [ion binding]; other site 1032480000793 structural Zn binding site [ion binding]; other site 1032480000794 YibE/F-like protein; Region: YibE_F; pfam07907 1032480000795 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1032480000796 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480000797 minor groove reading motif; other site 1032480000798 helix-hairpin-helix signature motif; other site 1032480000799 active site 1032480000800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480000801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480000802 dimerization interface [polypeptide binding]; other site 1032480000803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480000804 dimer interface [polypeptide binding]; other site 1032480000805 phosphorylation site [posttranslational modification] 1032480000806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480000807 ATP binding site [chemical binding]; other site 1032480000808 Mg2+ binding site [ion binding]; other site 1032480000809 G-X-G motif; other site 1032480000810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480000811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480000812 active site 1032480000813 phosphorylation site [posttranslational modification] 1032480000814 intermolecular recognition site; other site 1032480000815 dimerization interface [polypeptide binding]; other site 1032480000816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480000817 DNA binding site [nucleotide binding] 1032480000818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480000819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000820 MMPL family; Region: MMPL; pfam03176 1032480000821 ATP synthase I chain; Region: ATP_synt_I; cl09170 1032480000822 MMPL family; Region: MMPL; pfam03176 1032480000823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000824 Walker A/P-loop; other site 1032480000825 ATP binding site [chemical binding]; other site 1032480000826 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480000827 Predicted membrane protein [Function unknown]; Region: COG1511 1032480000828 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480000829 Capsid protein (F protein); Region: Phage_F; cl15846 1032480000830 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480000831 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1032480000832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480000833 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480000834 active site 1032480000835 CAAX protease self-immunity; Region: Abi; pfam02517 1032480000836 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1032480000837 Ferritin-like domain; Region: Ferritin; pfam00210 1032480000838 ferroxidase diiron center [ion binding]; other site 1032480000839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480000840 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480000841 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480000842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480000843 NAD(P) binding site [chemical binding]; other site 1032480000844 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1032480000845 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480000846 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480000847 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480000848 active site 1032480000849 Membrane protein of unknown function; Region: DUF360; pfam04020 1032480000850 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480000851 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1032480000852 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1032480000853 NAD binding site [chemical binding]; other site 1032480000854 catalytic Zn binding site [ion binding]; other site 1032480000855 substrate binding site [chemical binding]; other site 1032480000856 structural Zn binding site [ion binding]; other site 1032480000857 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480000859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000860 Walker A/P-loop; other site 1032480000861 ATP binding site [chemical binding]; other site 1032480000862 Q-loop/lid; other site 1032480000863 ABC transporter signature motif; other site 1032480000864 Walker B; other site 1032480000865 D-loop; other site 1032480000866 H-loop/switch region; other site 1032480000867 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480000868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480000869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480000870 Walker A/P-loop; other site 1032480000871 ATP binding site [chemical binding]; other site 1032480000872 Q-loop/lid; other site 1032480000873 ABC transporter signature motif; other site 1032480000874 Walker B; other site 1032480000875 D-loop; other site 1032480000876 H-loop/switch region; other site 1032480000877 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480000878 AAA domain; Region: AAA_14; pfam13173 1032480000879 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1032480000880 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1032480000881 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1032480000882 homotrimer interface [polypeptide binding]; other site 1032480000883 Walker A motif; other site 1032480000884 GTP binding site [chemical binding]; other site 1032480000885 Walker B motif; other site 1032480000886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480000887 MarR family; Region: MarR_2; pfam12802 1032480000888 MarR family; Region: MarR_2; cl17246 1032480000889 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1032480000890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1032480000891 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1032480000892 tandem repeat interface [polypeptide binding]; other site 1032480000893 oligomer interface [polypeptide binding]; other site 1032480000894 active site residues [active] 1032480000895 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1032480000896 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1032480000897 oligomer interface [polypeptide binding]; other site 1032480000898 tandem repeat interface [polypeptide binding]; other site 1032480000899 active site residues [active] 1032480000900 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1032480000901 nudix motif; other site 1032480000902 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1032480000903 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1032480000904 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1032480000905 putative dimer interface [polypeptide binding]; other site 1032480000906 active site pocket [active] 1032480000907 putative cataytic base [active] 1032480000908 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1032480000909 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1032480000910 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1032480000911 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1032480000912 homodimer interface [polypeptide binding]; other site 1032480000913 active site 1032480000914 SAM binding site [chemical binding]; other site 1032480000915 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1032480000916 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1032480000917 catalytic triad [active] 1032480000918 hypothetical protein; Provisional; Region: PRK07908 1032480000919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480000920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480000921 homodimer interface [polypeptide binding]; other site 1032480000922 catalytic residue [active] 1032480000923 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1032480000924 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1032480000925 homodimer interface [polypeptide binding]; other site 1032480000926 Walker A motif; other site 1032480000927 ATP binding site [chemical binding]; other site 1032480000928 hydroxycobalamin binding site [chemical binding]; other site 1032480000929 Walker B motif; other site 1032480000930 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1032480000931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1032480000932 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1032480000933 metal ion-dependent adhesion site (MIDAS); other site 1032480000934 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1032480000935 active site 1032480000936 putative homodimer interface [polypeptide binding]; other site 1032480000937 SAM binding site [chemical binding]; other site 1032480000938 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1032480000939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480000940 S-adenosylmethionine binding site [chemical binding]; other site 1032480000941 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1032480000942 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1032480000943 active site 1032480000944 SAM binding site [chemical binding]; other site 1032480000945 homodimer interface [polypeptide binding]; other site 1032480000946 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1032480000947 substrate binding site [chemical binding]; other site 1032480000948 dimer interface [polypeptide binding]; other site 1032480000949 catalytic triad [active] 1032480000950 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1032480000951 dihydroxyacetone kinase; Provisional; Region: PRK14479 1032480000952 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1032480000953 DAK2 domain; Region: Dak2; pfam02734 1032480000954 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480000955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480000956 DNA-binding site [nucleotide binding]; DNA binding site 1032480000957 FCD domain; Region: FCD; pfam07729 1032480000958 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1032480000959 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1032480000960 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1032480000961 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480000962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480000963 classical (c) SDRs; Region: SDR_c; cd05233 1032480000964 NAD(P) binding site [chemical binding]; other site 1032480000965 active site 1032480000966 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1032480000967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480000968 putative substrate translocation pore; other site 1032480000969 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480000970 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480000971 NAD(P) binding site [chemical binding]; other site 1032480000972 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1032480000973 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1032480000974 putative active site pocket [active] 1032480000975 putative metal binding site [ion binding]; other site 1032480000976 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1032480000977 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1032480000978 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480000979 NAD(P) binding site [chemical binding]; other site 1032480000980 CCC1-related family of proteins; Region: CCC1_like; cl00278 1032480000981 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1032480000982 putative dimer interface [polypeptide binding]; other site 1032480000983 catalytic triad [active] 1032480000984 Integrase core domain; Region: rve; pfam00665 1032480000985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480000986 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480000987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480000988 Walker A motif; other site 1032480000989 ATP binding site [chemical binding]; other site 1032480000990 Walker B motif; other site 1032480000991 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480000992 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1032480000993 hypothetical protein; Reviewed; Region: PRK09588 1032480000994 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1032480000995 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480000996 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480000997 Ligand Binding Site [chemical binding]; other site 1032480000998 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1032480000999 active site 1032480001000 SAM binding site [chemical binding]; other site 1032480001001 homodimer interface [polypeptide binding]; other site 1032480001002 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1032480001003 active site 1032480001004 SAM binding site [chemical binding]; other site 1032480001005 homodimer interface [polypeptide binding]; other site 1032480001006 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1032480001007 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1032480001008 precorrin-3B synthase; Region: CobG; TIGR02435 1032480001009 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480001010 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480001011 catalytic core [active] 1032480001012 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1032480001013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1032480001014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480001015 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1032480001016 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1032480001017 putative NAD(P) binding site [chemical binding]; other site 1032480001018 catalytic Zn binding site [ion binding]; other site 1032480001019 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1032480001020 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1032480001021 NADP binding site [chemical binding]; other site 1032480001022 homodimer interface [polypeptide binding]; other site 1032480001023 active site 1032480001024 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1032480001025 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480001026 NAD binding site [chemical binding]; other site 1032480001027 ligand binding site [chemical binding]; other site 1032480001028 catalytic site [active] 1032480001029 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1032480001030 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1032480001031 DNA binding site [nucleotide binding] 1032480001032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1032480001033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1032480001034 catalytic residue [active] 1032480001035 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1032480001036 NlpC/P60 family; Region: NLPC_P60; cl17555 1032480001037 phage tail protein domain; Region: tail_TIGR02242 1032480001038 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1032480001039 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1032480001040 Phage protein D [General function prediction only]; Region: COG3500 1032480001041 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1032480001042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1032480001043 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1032480001044 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1032480001045 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1032480001046 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1032480001047 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480001048 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1032480001049 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1032480001050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001051 Walker A motif; other site 1032480001052 ATP binding site [chemical binding]; other site 1032480001053 Walker B motif; other site 1032480001054 arginine finger; other site 1032480001055 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1032480001056 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1032480001057 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1032480001058 nucleotide binding site [chemical binding]; other site 1032480001059 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1032480001060 SBD interface [polypeptide binding]; other site 1032480001061 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480001062 Interdomain contacts; other site 1032480001063 Cytokine receptor motif; other site 1032480001064 Sporulation related domain; Region: SPOR; cl10051 1032480001065 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1032480001066 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1032480001067 Double zinc ribbon; Region: DZR; pfam12773 1032480001068 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1032480001069 Double zinc ribbon; Region: DZR; pfam12773 1032480001070 Dynamin family; Region: Dynamin_N; pfam00350 1032480001071 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1032480001072 G1 box; other site 1032480001073 GTP/Mg2+ binding site [chemical binding]; other site 1032480001074 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1032480001075 G3 box; other site 1032480001076 Switch II region; other site 1032480001077 GTP/Mg2+ binding site [chemical binding]; other site 1032480001078 G4 box; other site 1032480001079 G5 box; other site 1032480001080 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1032480001081 G1 box; other site 1032480001082 GTP/Mg2+ binding site [chemical binding]; other site 1032480001083 G2 box; other site 1032480001084 Switch I region; other site 1032480001085 G3 box; other site 1032480001086 Switch II region; other site 1032480001087 G4 box; other site 1032480001088 G5 box; other site 1032480001089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480001090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001091 DNA binding residues [nucleotide binding] 1032480001092 dimerization interface [polypeptide binding]; other site 1032480001093 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480001094 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1032480001095 active site 1032480001096 ATP binding site [chemical binding]; other site 1032480001097 substrate binding site [chemical binding]; other site 1032480001098 activation loop (A-loop); other site 1032480001099 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1032480001100 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1032480001101 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1032480001102 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1032480001103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480001104 S-adenosylmethionine binding site [chemical binding]; other site 1032480001105 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480001106 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1032480001107 ATP binding site [chemical binding]; other site 1032480001108 active site 1032480001109 substrate binding site [chemical binding]; other site 1032480001110 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1032480001111 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1032480001112 active site 1032480001113 SAM binding site [chemical binding]; other site 1032480001114 homodimer interface [polypeptide binding]; other site 1032480001115 cobyric acid synthase; Provisional; Region: PRK00784 1032480001116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480001117 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1032480001118 catalytic triad [active] 1032480001119 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480001120 active site 1032480001121 NTP binding site [chemical binding]; other site 1032480001122 metal binding triad [ion binding]; metal-binding site 1032480001123 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 1032480001124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001125 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480001126 catalytic site [active] 1032480001127 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1032480001128 AAA ATPase domain; Region: AAA_16; pfam13191 1032480001129 Walker A motif; other site 1032480001130 ATP binding site [chemical binding]; other site 1032480001131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480001132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001133 DNA binding residues [nucleotide binding] 1032480001134 dimerization interface [polypeptide binding]; other site 1032480001135 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480001136 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480001137 active site 1032480001138 TDP-binding site; other site 1032480001139 acceptor substrate-binding pocket; other site 1032480001140 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480001141 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1032480001142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001143 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1032480001144 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1032480001145 EamA-like transporter family; Region: EamA; pfam00892 1032480001146 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480001147 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480001148 aspartate aminotransferase; Provisional; Region: PRK05764 1032480001149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001151 homodimer interface [polypeptide binding]; other site 1032480001152 catalytic residue [active] 1032480001153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1032480001154 YCII-related domain; Region: YCII; cl00999 1032480001155 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480001156 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1032480001158 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1032480001159 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1032480001160 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1032480001161 active site 1032480001162 NAD binding site [chemical binding]; other site 1032480001163 metal binding site [ion binding]; metal-binding site 1032480001164 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1032480001165 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1032480001166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480001167 minor groove reading motif; other site 1032480001168 helix-hairpin-helix signature motif; other site 1032480001169 substrate binding pocket [chemical binding]; other site 1032480001170 active site 1032480001171 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1032480001172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480001173 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1032480001174 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1032480001175 active site clefts [active] 1032480001176 zinc binding site [ion binding]; other site 1032480001177 dimer interface [polypeptide binding]; other site 1032480001178 LssY C-terminus; Region: LssY_C; pfam14067 1032480001179 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1032480001180 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1032480001181 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1032480001182 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480001183 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480001184 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480001185 active site 1032480001186 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480001187 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480001188 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480001189 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480001190 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1032480001191 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1032480001192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480001193 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1032480001194 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480001195 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480001196 AAA ATPase domain; Region: AAA_16; pfam13191 1032480001197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480001198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001199 DNA binding residues [nucleotide binding] 1032480001200 dimerization interface [polypeptide binding]; other site 1032480001201 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1032480001202 ATP binding site [chemical binding]; other site 1032480001203 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1032480001204 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1032480001205 TPP-binding site [chemical binding]; other site 1032480001206 heterodimer interface [polypeptide binding]; other site 1032480001207 tetramer interface [polypeptide binding]; other site 1032480001208 phosphorylation loop region [posttranslational modification] 1032480001209 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1032480001210 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1032480001211 alpha subunit interface [polypeptide binding]; other site 1032480001212 TPP binding site [chemical binding]; other site 1032480001213 heterodimer interface [polypeptide binding]; other site 1032480001214 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480001215 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1032480001216 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480001217 E3 interaction surface; other site 1032480001218 lipoyl attachment site [posttranslational modification]; other site 1032480001219 e3 binding domain; Region: E3_binding; pfam02817 1032480001220 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1032480001221 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001222 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480001223 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480001224 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001225 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480001226 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1032480001227 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480001228 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480001229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480001230 active site 1032480001231 phosphorylation site [posttranslational modification] 1032480001232 intermolecular recognition site; other site 1032480001233 dimerization interface [polypeptide binding]; other site 1032480001234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480001235 DNA binding residues [nucleotide binding] 1032480001236 dimerization interface [polypeptide binding]; other site 1032480001237 Histidine kinase; Region: HisKA_3; pfam07730 1032480001238 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480001239 ATP binding site [chemical binding]; other site 1032480001240 Mg2+ binding site [ion binding]; other site 1032480001241 G-X-G motif; other site 1032480001242 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1032480001243 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1032480001244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480001245 active site 1032480001246 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1032480001247 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480001248 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480001249 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480001250 DinB superfamily; Region: DinB_2; pfam12867 1032480001251 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1032480001252 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1032480001253 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1032480001254 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1032480001255 putative active site [active] 1032480001256 putative substrate binding site [chemical binding]; other site 1032480001257 putative cosubstrate binding site; other site 1032480001258 catalytic site [active] 1032480001259 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480001260 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480001261 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1032480001262 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480001263 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1032480001264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001265 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1032480001266 Divergent AAA domain; Region: AAA_4; pfam04326 1032480001267 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480001268 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 1032480001269 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480001270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001271 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480001272 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480001273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001274 putative substrate translocation pore; other site 1032480001275 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1032480001276 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1032480001277 putative NAD(P) binding site [chemical binding]; other site 1032480001278 dimer interface [polypeptide binding]; other site 1032480001279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001281 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480001282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480001283 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1032480001284 DNA binding residues [nucleotide binding] 1032480001285 HD domain; Region: HD; pfam01966 1032480001286 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1032480001287 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480001288 hydrophobic ligand binding site; other site 1032480001289 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1032480001290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480001291 inhibitor-cofactor binding pocket; inhibition site 1032480001292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001293 catalytic residue [active] 1032480001294 Male sterility protein; Region: NAD_binding_4; pfam07993 1032480001295 NAD(P) binding site [chemical binding]; other site 1032480001296 active site 1032480001297 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480001298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480001299 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1032480001300 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1032480001301 MMPL family; Region: MMPL; pfam03176 1032480001302 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1032480001303 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1032480001304 Cytochrome P450; Region: p450; cl12078 1032480001305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480001306 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1032480001307 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480001308 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1032480001309 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480001310 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480001311 active site 1032480001312 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480001313 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1032480001314 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480001315 active site 1032480001316 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480001317 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480001318 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1032480001319 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1032480001320 nucleotide binding site [chemical binding]; other site 1032480001321 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1032480001322 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1032480001323 active site 1032480001324 DNA binding site [nucleotide binding] 1032480001325 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1032480001326 DNA binding site [nucleotide binding] 1032480001327 DinB superfamily; Region: DinB_2; pfam12867 1032480001328 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480001329 nudix motif; other site 1032480001330 carboxylate-amine ligase; Provisional; Region: PRK13517 1032480001331 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1032480001332 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1032480001333 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1032480001334 active site 1032480001335 ATP-binding site [chemical binding]; other site 1032480001336 pantoate-binding site; other site 1032480001337 HXXH motif; other site 1032480001338 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1032480001339 oligomerization interface [polypeptide binding]; other site 1032480001340 active site 1032480001341 metal binding site [ion binding]; metal-binding site 1032480001342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480001343 active site 1032480001344 nucleotide binding site [chemical binding]; other site 1032480001345 HIGH motif; other site 1032480001346 KMSKS motif; other site 1032480001347 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1032480001348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001350 homodimer interface [polypeptide binding]; other site 1032480001351 catalytic residue [active] 1032480001352 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480001354 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480001355 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480001356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480001357 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1032480001358 active site 1032480001359 DNA binding site [nucleotide binding] 1032480001360 mercuric reductase; Validated; Region: PRK06370 1032480001361 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1032480001362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480001363 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480001364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001366 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480001367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480001368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480001369 active site 1032480001370 catalytic tetrad [active] 1032480001371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480001372 salt bridge; other site 1032480001373 non-specific DNA binding site [nucleotide binding]; other site 1032480001374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480001375 sequence-specific DNA binding site [nucleotide binding]; other site 1032480001376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001378 putative substrate translocation pore; other site 1032480001379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001380 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480001381 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480001382 shikimate binding site; other site 1032480001383 NAD(P) binding site [chemical binding]; other site 1032480001384 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480001385 Ligand Binding Site [chemical binding]; other site 1032480001386 Amino acid permease; Region: AA_permease_2; pfam13520 1032480001387 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1032480001388 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1032480001389 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1032480001390 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1032480001391 active site 1032480001392 dimer interface [polypeptide binding]; other site 1032480001393 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1032480001394 dimer interface [polypeptide binding]; other site 1032480001395 active site 1032480001396 Alkylmercury lyase; Region: MerB; pfam03243 1032480001397 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1032480001398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480001399 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480001400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480001401 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1032480001402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1032480001403 active site 1032480001404 motif I; other site 1032480001405 motif II; other site 1032480001406 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480001407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480001408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480001409 DNA binding residues [nucleotide binding] 1032480001410 YCII-related domain; Region: YCII; cl00999 1032480001411 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1032480001412 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1032480001413 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1032480001414 catalytic residues [active] 1032480001415 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1032480001416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480001417 motif II; other site 1032480001418 SnoaL-like domain; Region: SnoaL_3; pfam13474 1032480001419 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1032480001420 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480001421 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480001422 DNA binding residues [nucleotide binding] 1032480001423 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1032480001424 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1032480001425 putative dimer interface [polypeptide binding]; other site 1032480001426 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1032480001427 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001428 molybdopterin cofactor binding site; other site 1032480001429 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001430 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480001431 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1032480001432 molybdopterin cofactor binding site; other site 1032480001433 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1032480001434 4Fe-4S binding domain; Region: Fer4; cl02805 1032480001435 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1032480001436 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480001437 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1032480001438 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1032480001439 dimerization interface [polypeptide binding]; other site 1032480001440 putative ATP binding site [chemical binding]; other site 1032480001441 selenocysteine synthase; Provisional; Region: PRK04311 1032480001442 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480001443 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1032480001444 GTPases - translation elongation factors [Translation, ribosomal structure and biogenesis]; Region: TufB; COG0050 1032480001445 G1 box; other site 1032480001446 putative GEF interaction site [polypeptide binding]; other site 1032480001447 GTP/Mg2+ binding site [chemical binding]; other site 1032480001448 Switch I region; other site 1032480001449 G2 box; other site 1032480001450 G3 box; other site 1032480001451 Switch II region; other site 1032480001452 G4 box; other site 1032480001453 G5 box; other site 1032480001454 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1032480001455 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1032480001456 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1032480001457 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1032480001458 putative active site [active] 1032480001459 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1032480001460 minor groove reading motif; other site 1032480001461 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480001462 helix-hairpin-helix signature motif; other site 1032480001463 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480001464 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1032480001465 putative DNA binding site [nucleotide binding]; other site 1032480001466 catalytic residue [active] 1032480001467 putative H2TH interface [polypeptide binding]; other site 1032480001468 putative catalytic residues [active] 1032480001469 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480001470 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480001471 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1032480001472 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1032480001473 NodB motif; other site 1032480001474 active site 1032480001475 catalytic site [active] 1032480001476 metal binding site [ion binding]; metal-binding site 1032480001477 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1032480001478 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1032480001479 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1032480001480 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1032480001481 active site 1032480001482 HIGH motif; other site 1032480001483 KMSK motif region; other site 1032480001484 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1032480001485 tRNA binding surface [nucleotide binding]; other site 1032480001486 anticodon binding site; other site 1032480001487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480001488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1032480001489 nucleotide binding site [chemical binding]; other site 1032480001490 Predicted membrane protein [Function unknown]; Region: COG3428 1032480001491 Bacterial PH domain; Region: DUF304; pfam03703 1032480001492 Bacterial PH domain; Region: DUF304; cl01348 1032480001493 Bacterial PH domain; Region: DUF304; pfam03703 1032480001494 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480001495 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1032480001496 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480001497 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1032480001498 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480001499 AAA domain; Region: AAA_14; pfam13173 1032480001500 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480001501 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480001502 active site 1032480001503 metal binding site [ion binding]; metal-binding site 1032480001504 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1032480001505 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480001506 Predicted ATPase [General function prediction only]; Region: COG3903 1032480001507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001508 NAD(P) binding site [chemical binding]; other site 1032480001509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480001510 active site 1032480001511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001513 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1032480001514 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1032480001515 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480001516 metal binding site [ion binding]; metal-binding site 1032480001517 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480001518 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1032480001519 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480001520 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1032480001521 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480001522 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480001523 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1032480001524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001525 putative substrate translocation pore; other site 1032480001526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001527 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 1032480001528 putative active site [active] 1032480001529 putative catalytic site [active] 1032480001530 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480001531 hypothetical protein; Provisional; Region: PRK04194 1032480001532 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1032480001533 AIR carboxylase; Region: AIRC; smart01001 1032480001534 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1032480001535 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1032480001536 Ligand Binding Site [chemical binding]; other site 1032480001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001538 putative transporter; Provisional; Region: PRK10504 1032480001539 putative substrate translocation pore; other site 1032480001540 altronate oxidoreductase; Provisional; Region: PRK03643 1032480001541 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1032480001542 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1032480001543 glucuronate isomerase; Reviewed; Region: PRK02925 1032480001544 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1032480001545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001547 DNA binding site [nucleotide binding] 1032480001548 domain linker motif; other site 1032480001549 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480001550 dimerization interface [polypeptide binding]; other site 1032480001551 ligand binding site [chemical binding]; other site 1032480001552 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480001553 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480001554 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480001555 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480001556 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480001557 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1032480001558 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1032480001559 MOSC domain; Region: MOSC; pfam03473 1032480001560 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1032480001561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480001562 active site 1032480001563 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480001564 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480001565 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480001566 FAD binding pocket [chemical binding]; other site 1032480001567 FAD binding motif [chemical binding]; other site 1032480001568 phosphate binding motif [ion binding]; other site 1032480001569 NAD binding pocket [chemical binding]; other site 1032480001570 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1032480001571 phosphopeptide binding site; other site 1032480001572 RDD family; Region: RDD; pfam06271 1032480001573 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1032480001574 phosphopeptide binding site; other site 1032480001575 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1032480001576 trimer interface [polypeptide binding]; other site 1032480001577 active site 1032480001578 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1032480001579 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1032480001580 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1032480001581 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1032480001582 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1032480001583 Walker A/P-loop; other site 1032480001584 ATP binding site [chemical binding]; other site 1032480001585 Q-loop/lid; other site 1032480001586 ABC transporter signature motif; other site 1032480001587 Walker B; other site 1032480001588 D-loop; other site 1032480001589 H-loop/switch region; other site 1032480001590 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1032480001591 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1032480001592 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1032480001593 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480001594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480001595 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1032480001596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480001597 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480001598 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480001599 active site 1032480001600 ATP binding site [chemical binding]; other site 1032480001601 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480001602 active site 1032480001603 NTP binding site [chemical binding]; other site 1032480001604 metal binding triad [ion binding]; metal-binding site 1032480001605 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1032480001606 nucleotide binding site [chemical binding]; other site 1032480001607 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480001608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480001609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480001610 Walker A/P-loop; other site 1032480001611 ATP binding site [chemical binding]; other site 1032480001612 Q-loop/lid; other site 1032480001613 ABC transporter signature motif; other site 1032480001614 Walker B; other site 1032480001615 D-loop; other site 1032480001616 H-loop/switch region; other site 1032480001617 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1032480001618 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1032480001619 active site pocket [active] 1032480001620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480001621 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1032480001622 dimerization interface [polypeptide binding]; other site 1032480001623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480001624 dimer interface [polypeptide binding]; other site 1032480001625 phosphorylation site [posttranslational modification] 1032480001626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480001627 ATP binding site [chemical binding]; other site 1032480001628 Mg2+ binding site [ion binding]; other site 1032480001629 G-X-G motif; other site 1032480001630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480001631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480001632 active site 1032480001633 phosphorylation site [posttranslational modification] 1032480001634 intermolecular recognition site; other site 1032480001635 dimerization interface [polypeptide binding]; other site 1032480001636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480001637 DNA binding site [nucleotide binding] 1032480001638 Predicted membrane protein [Function unknown]; Region: COG2259 1032480001639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1032480001640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1032480001641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1032480001642 dimer interface [polypeptide binding]; other site 1032480001643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480001644 dimerization interface [polypeptide binding]; other site 1032480001645 putative DNA binding site [nucleotide binding]; other site 1032480001646 putative Zn2+ binding site [ion binding]; other site 1032480001647 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480001648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001649 putative acetyltransferase; Provisional; Region: PRK03624 1032480001650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480001651 Coenzyme A binding pocket [chemical binding]; other site 1032480001652 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 1032480001653 metal binding site [ion binding]; metal-binding site 1032480001654 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480001655 extended (e) SDRs; Region: SDR_e; cd08946 1032480001656 NAD(P) binding site [chemical binding]; other site 1032480001657 active site 1032480001658 substrate binding site [chemical binding]; other site 1032480001659 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1032480001660 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1032480001661 nucleotide binding site [chemical binding]; other site 1032480001662 NEF interaction site [polypeptide binding]; other site 1032480001663 SBD interface [polypeptide binding]; other site 1032480001664 GrpE; Region: GrpE; pfam01025 1032480001665 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1032480001666 dimer interface [polypeptide binding]; other site 1032480001667 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1032480001668 chaperone protein DnaJ; Provisional; Region: PRK14295 1032480001669 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1032480001670 HSP70 interaction site [polypeptide binding]; other site 1032480001671 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1032480001672 Zn binding sites [ion binding]; other site 1032480001673 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1032480001674 dimer interface [polypeptide binding]; other site 1032480001675 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1032480001676 DNA binding residues [nucleotide binding] 1032480001677 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480001678 putative dimer interface [polypeptide binding]; other site 1032480001679 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1032480001680 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1032480001681 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480001682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001683 Walker A motif; other site 1032480001684 ATP binding site [chemical binding]; other site 1032480001685 Walker B motif; other site 1032480001686 arginine finger; other site 1032480001687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001688 Walker A motif; other site 1032480001689 ATP binding site [chemical binding]; other site 1032480001690 Walker B motif; other site 1032480001691 arginine finger; other site 1032480001692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1032480001693 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1032480001694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480001695 dimer interface [polypeptide binding]; other site 1032480001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480001697 CAAX protease self-immunity; Region: Abi; pfam02517 1032480001698 imidazolonepropionase; Provisional; Region: PRK14085 1032480001699 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1032480001700 active site 1032480001701 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1032480001702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480001703 active site 1032480001704 allantoate amidohydrolase; Reviewed; Region: PRK09290 1032480001705 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1032480001706 active site 1032480001707 metal binding site [ion binding]; metal-binding site 1032480001708 dimer interface [polypeptide binding]; other site 1032480001709 urocanate hydratase; Provisional; Region: PRK05414 1032480001710 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1032480001711 active sites [active] 1032480001712 tetramer interface [polypeptide binding]; other site 1032480001713 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480001714 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1032480001715 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480001716 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001718 putative substrate translocation pore; other site 1032480001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001720 aminotransferase; Validated; Region: PRK07777 1032480001721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480001723 homodimer interface [polypeptide binding]; other site 1032480001724 catalytic residue [active] 1032480001725 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480001726 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1032480001727 active site 1032480001728 catalytic site [active] 1032480001729 Domain of unknown function DUF87; Region: DUF87; pfam01935 1032480001730 AAA-like domain; Region: AAA_10; pfam12846 1032480001731 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1032480001732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480001733 active site 1032480001734 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1032480001735 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480001736 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480001737 active site 1032480001738 catalytic tetrad [active] 1032480001739 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480001740 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1032480001741 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1032480001742 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1032480001743 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1032480001744 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1032480001745 putative active site [active] 1032480001746 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1032480001747 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480001748 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1032480001749 active site 1032480001750 catalytic site [active] 1032480001751 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1032480001752 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1032480001753 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1032480001754 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1032480001755 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1032480001756 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1032480001757 Ca binding site [ion binding]; other site 1032480001758 active site 1032480001759 catalytic site [active] 1032480001760 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1032480001761 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480001762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001763 DNA-binding site [nucleotide binding]; DNA binding site 1032480001764 FCD domain; Region: FCD; pfam07729 1032480001765 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1032480001766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480001767 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480001768 substrate binding pocket [chemical binding]; other site 1032480001769 membrane-bound complex binding site; other site 1032480001770 hinge residues; other site 1032480001771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1032480001772 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480001773 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480001774 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480001775 metal binding triad; other site 1032480001776 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1032480001777 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480001778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001779 DNA-binding site [nucleotide binding]; DNA binding site 1032480001780 UTRA domain; Region: UTRA; pfam07702 1032480001781 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480001782 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480001783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001785 DNA binding site [nucleotide binding] 1032480001786 domain linker motif; other site 1032480001787 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001788 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1032480001789 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1032480001790 active site 1032480001791 intersubunit interface [polypeptide binding]; other site 1032480001792 zinc binding site [ion binding]; other site 1032480001793 Na+ binding site [ion binding]; other site 1032480001794 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1032480001795 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1032480001796 oligomer interface [polypeptide binding]; other site 1032480001797 metal binding site [ion binding]; metal-binding site 1032480001798 metal binding site [ion binding]; metal-binding site 1032480001799 putative Cl binding site [ion binding]; other site 1032480001800 aspartate ring; other site 1032480001801 basic sphincter; other site 1032480001802 hydrophobic gate; other site 1032480001803 periplasmic entrance; other site 1032480001804 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1032480001805 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 1032480001806 FAD dependent oxidoreductase; Region: DAO; pfam01266 1032480001807 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1032480001808 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1032480001809 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1032480001810 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1032480001811 GDP-binding site [chemical binding]; other site 1032480001812 ACT binding site; other site 1032480001813 IMP binding site; other site 1032480001814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001816 DNA binding site [nucleotide binding] 1032480001817 domain linker motif; other site 1032480001818 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001819 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1032480001820 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1032480001821 substrate binding [chemical binding]; other site 1032480001822 active site 1032480001823 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1032480001824 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1032480001825 substrate binding [chemical binding]; other site 1032480001826 active site 1032480001827 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1032480001828 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480001829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001830 dimer interface [polypeptide binding]; other site 1032480001831 conserved gate region; other site 1032480001832 putative PBP binding loops; other site 1032480001833 ABC-ATPase subunit interface; other site 1032480001834 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480001835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001836 putative PBP binding loops; other site 1032480001837 dimer interface [polypeptide binding]; other site 1032480001838 ABC-ATPase subunit interface; other site 1032480001839 potential frameshift: common BLAST hit: gi|229819326|ref|YP_002880852.1| extracellular solute-binding protein family 1 1032480001840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480001841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480001842 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480001843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480001844 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1032480001845 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1032480001846 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1032480001847 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1032480001848 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1032480001849 tetramer interface [polypeptide binding]; other site 1032480001850 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480001851 classical (c) SDRs; Region: SDR_c; cd05233 1032480001852 NAD(P) binding site [chemical binding]; other site 1032480001853 active site 1032480001854 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480001855 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480001856 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480001857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480001858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480001859 Walker A/P-loop; other site 1032480001860 ATP binding site [chemical binding]; other site 1032480001861 Q-loop/lid; other site 1032480001862 ABC transporter signature motif; other site 1032480001863 Walker B; other site 1032480001864 D-loop; other site 1032480001865 H-loop/switch region; other site 1032480001866 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1032480001867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480001868 Walker A motif; other site 1032480001869 ATP binding site [chemical binding]; other site 1032480001870 Walker B motif; other site 1032480001871 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480001872 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480001873 PspC domain; Region: PspC; pfam04024 1032480001874 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1032480001875 ATP binding site [chemical binding]; other site 1032480001876 active site 1032480001877 substrate binding site [chemical binding]; other site 1032480001878 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1032480001879 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1032480001880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1032480001881 putative active site [active] 1032480001882 catalytic triad [active] 1032480001883 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480001884 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1032480001885 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1032480001886 dimerization interface [polypeptide binding]; other site 1032480001887 ATP binding site [chemical binding]; other site 1032480001888 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1032480001889 dimerization interface [polypeptide binding]; other site 1032480001890 ATP binding site [chemical binding]; other site 1032480001891 hypothetical protein; Provisional; Region: PRK02947 1032480001892 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1032480001893 putative active site [active] 1032480001894 hypothetical protein; Provisional; Region: PRK07907 1032480001895 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1032480001896 active site 1032480001897 metal binding site [ion binding]; metal-binding site 1032480001898 dimer interface [polypeptide binding]; other site 1032480001899 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1032480001900 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1032480001901 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1032480001902 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480001903 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1032480001904 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1032480001905 active site 1032480001906 tetramer interface [polypeptide binding]; other site 1032480001907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480001908 active site 1032480001909 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1032480001910 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1032480001911 dimerization interface [polypeptide binding]; other site 1032480001912 putative ATP binding site [chemical binding]; other site 1032480001913 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1032480001914 Tic20-like protein; Region: Tic20; pfam09685 1032480001915 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480001916 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480001917 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1032480001918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480001919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480001920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480001922 DNA binding site [nucleotide binding] 1032480001923 domain linker motif; other site 1032480001924 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480001925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001927 putative substrate translocation pore; other site 1032480001928 Probable beta-xylosidase; Provisional; Region: PLN03080 1032480001929 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480001930 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480001931 Survival protein SurE; Region: SurE; cl00448 1032480001932 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1032480001933 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480001934 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1032480001935 domain linker motif; other site 1032480001936 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480001937 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1032480001938 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480001939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001940 dimer interface [polypeptide binding]; other site 1032480001941 conserved gate region; other site 1032480001942 putative PBP binding loops; other site 1032480001943 ABC-ATPase subunit interface; other site 1032480001944 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1032480001945 Right handed beta helix region; Region: Beta_helix; pfam13229 1032480001946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480001947 dimerization interface [polypeptide binding]; other site 1032480001948 putative DNA binding site [nucleotide binding]; other site 1032480001949 putative Zn2+ binding site [ion binding]; other site 1032480001950 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480001951 putative hydrophobic ligand binding site [chemical binding]; other site 1032480001952 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480001953 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480001954 NAD(P) binding site [chemical binding]; other site 1032480001955 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480001956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480001957 DNA-binding site [nucleotide binding]; DNA binding site 1032480001958 UTRA domain; Region: UTRA; pfam07702 1032480001959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480001960 nucleotide binding site [chemical binding]; other site 1032480001961 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480001962 D-xylulose kinase; Region: XylB; TIGR01312 1032480001963 nucleotide binding site [chemical binding]; other site 1032480001964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480001965 D-xylulose kinase; Region: XylB; TIGR01312 1032480001966 nucleotide binding site [chemical binding]; other site 1032480001967 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1032480001968 intersubunit interface [polypeptide binding]; other site 1032480001969 active site 1032480001970 zinc binding site [ion binding]; other site 1032480001971 Na+ binding site [ion binding]; other site 1032480001972 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480001973 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480001974 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1032480001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001976 dimer interface [polypeptide binding]; other site 1032480001977 conserved gate region; other site 1032480001978 putative PBP binding loops; other site 1032480001979 ABC-ATPase subunit interface; other site 1032480001980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480001981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480001982 dimer interface [polypeptide binding]; other site 1032480001983 conserved gate region; other site 1032480001984 putative PBP binding loops; other site 1032480001985 ABC-ATPase subunit interface; other site 1032480001986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480001987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480001988 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001989 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480001990 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1032480001991 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1032480001992 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480001993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480001995 putative substrate translocation pore; other site 1032480001996 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1032480001997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480001998 putative substrate translocation pore; other site 1032480001999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480002002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002003 S-adenosylmethionine binding site [chemical binding]; other site 1032480002004 Bacterial SH3 domain; Region: SH3_3; pfam08239 1032480002005 Bacterial SH3 domain; Region: SH3_3; pfam08239 1032480002006 Bacterial SH3 domain; Region: SH3_3; pfam08239 1032480002007 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1032480002008 Domain of unknown function (DUF202); Region: DUF202; cl09954 1032480002009 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1032480002010 EamA-like transporter family; Region: EamA; pfam00892 1032480002011 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1032480002012 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1032480002013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480002014 active site 1032480002015 DNA binding site [nucleotide binding] 1032480002016 Int/Topo IB signature motif; other site 1032480002017 putative transposase OrfB; Reviewed; Region: PHA02517 1032480002018 HTH-like domain; Region: HTH_21; pfam13276 1032480002019 Integrase core domain; Region: rve; pfam00665 1032480002020 Integrase core domain; Region: rve_3; pfam13683 1032480002021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480002022 Transposase; Region: HTH_Tnp_1; cl17663 1032480002023 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480002024 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480002025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002026 DNA-binding site [nucleotide binding]; DNA binding site 1032480002027 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480002028 nudix motif; other site 1032480002029 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480002030 nudix motif; other site 1032480002031 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002032 Protein of unknown function (DUF433); Region: DUF433; cl01030 1032480002033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480002034 metal ion-dependent adhesion site (MIDAS); other site 1032480002035 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1032480002036 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1032480002037 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480002038 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480002039 catalytic residue [active] 1032480002040 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480002041 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1032480002042 Amidohydrolase; Region: Amidohydro_2; pfam04909 1032480002043 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002044 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002045 active site 1032480002046 catalytic tetrad [active] 1032480002047 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1032480002048 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 1032480002049 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1032480002050 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1032480002051 metal binding site [ion binding]; metal-binding site 1032480002052 substrate binding pocket [chemical binding]; other site 1032480002053 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1032480002054 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1032480002055 short chain dehydrogenase; Provisional; Region: PRK06138 1032480002056 classical (c) SDRs; Region: SDR_c; cd05233 1032480002057 NAD(P) binding site [chemical binding]; other site 1032480002058 active site 1032480002059 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1032480002060 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1032480002061 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1032480002062 active site 1032480002063 octamer interface [polypeptide binding]; other site 1032480002064 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1032480002065 DNA binding residues [nucleotide binding] 1032480002066 dimerization interface [polypeptide binding]; other site 1032480002067 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1032480002068 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1032480002069 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1032480002070 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480002071 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480002072 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1032480002073 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480002074 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1032480002075 UbiA prenyltransferase family; Region: UbiA; pfam01040 1032480002076 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1032480002077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002078 acyl-activating enzyme (AAE) consensus motif; other site 1032480002079 AMP binding site [chemical binding]; other site 1032480002080 active site 1032480002081 CoA binding site [chemical binding]; other site 1032480002082 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1032480002083 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1032480002084 active site 1032480002085 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1032480002086 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1032480002087 dimer interface [polypeptide binding]; other site 1032480002088 tetramer interface [polypeptide binding]; other site 1032480002089 PYR/PP interface [polypeptide binding]; other site 1032480002090 TPP binding site [chemical binding]; other site 1032480002091 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1032480002092 TPP-binding site; other site 1032480002093 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1032480002094 threonine dehydratase; Provisional; Region: PRK08246 1032480002095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480002096 catalytic residue [active] 1032480002097 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480002098 short chain dehydrogenase; Provisional; Region: PRK07060 1032480002099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002100 NAD(P) binding site [chemical binding]; other site 1032480002101 active site 1032480002102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480002103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480002104 DNA binding site [nucleotide binding] 1032480002105 domain linker motif; other site 1032480002106 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480002107 dimerization interface [polypeptide binding]; other site 1032480002108 ligand binding site [chemical binding]; other site 1032480002109 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480002110 AAA domain; Region: AAA_14; pfam13173 1032480002111 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480002112 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480002113 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480002114 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480002115 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1032480002116 B3/4 domain; Region: B3_4; pfam03483 1032480002117 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1032480002118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480002119 non-specific DNA binding site [nucleotide binding]; other site 1032480002120 salt bridge; other site 1032480002121 sequence-specific DNA binding site [nucleotide binding]; other site 1032480002122 Cupin domain; Region: Cupin_2; pfam07883 1032480002123 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1032480002124 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1032480002125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002126 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1032480002127 active site 1032480002128 Mn binding site [ion binding]; other site 1032480002129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002131 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1032480002132 beta-galactosidase; Region: BGL; TIGR03356 1032480002133 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1032480002134 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480002135 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1032480002136 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1032480002137 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1032480002138 dimer interface [polypeptide binding]; other site 1032480002139 NADP binding site [chemical binding]; other site 1032480002140 catalytic residues [active] 1032480002141 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1032480002142 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1032480002143 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480002144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002145 S-adenosylmethionine binding site [chemical binding]; other site 1032480002146 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1032480002147 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1032480002148 Walker A/P-loop; other site 1032480002149 ATP binding site [chemical binding]; other site 1032480002150 Q-loop/lid; other site 1032480002151 ABC transporter signature motif; other site 1032480002152 Walker B; other site 1032480002153 D-loop; other site 1032480002154 H-loop/switch region; other site 1032480002155 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1032480002156 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1032480002157 active site 1032480002158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480002159 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1032480002160 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1032480002161 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1032480002162 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1032480002163 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1032480002164 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1032480002165 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1032480002166 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1032480002167 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1032480002168 putative dimer interface [polypeptide binding]; other site 1032480002169 [2Fe-2S] cluster binding site [ion binding]; other site 1032480002170 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1032480002171 SLBB domain; Region: SLBB; pfam10531 1032480002172 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1032480002173 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1032480002174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1032480002175 catalytic loop [active] 1032480002176 iron binding site [ion binding]; other site 1032480002177 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1032480002178 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480002179 molybdopterin cofactor binding site; other site 1032480002180 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1032480002181 molybdopterin cofactor binding site; other site 1032480002182 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1032480002183 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1032480002184 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1032480002185 4Fe-4S binding domain; Region: Fer4; pfam00037 1032480002186 4Fe-4S binding domain; Region: Fer4; pfam00037 1032480002187 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1032480002188 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1032480002189 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1032480002190 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1032480002191 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1032480002192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1032480002193 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 1032480002194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1032480002195 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1032480002196 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1032480002197 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1032480002198 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480002199 substrate binding pocket [chemical binding]; other site 1032480002200 chain length determination region; other site 1032480002201 substrate-Mg2+ binding site; other site 1032480002202 catalytic residues [active] 1032480002203 aspartate-rich region 1; other site 1032480002204 active site lid residues [active] 1032480002205 aspartate-rich region 2; other site 1032480002206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480002207 ABC transporter signature motif; other site 1032480002208 Walker B; other site 1032480002209 D-loop; other site 1032480002210 H-loop/switch region; other site 1032480002211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480002212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480002213 Walker A/P-loop; other site 1032480002214 ATP binding site [chemical binding]; other site 1032480002215 Q-loop/lid; other site 1032480002216 ABC transporter signature motif; other site 1032480002217 Walker B; other site 1032480002218 D-loop; other site 1032480002219 H-loop/switch region; other site 1032480002220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480002221 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1032480002222 metal binding site 2 [ion binding]; metal-binding site 1032480002223 putative DNA binding helix; other site 1032480002224 metal binding site 1 [ion binding]; metal-binding site 1032480002225 dimer interface [polypeptide binding]; other site 1032480002226 structural Zn2+ binding site [ion binding]; other site 1032480002227 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1032480002228 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1032480002229 dimer interface [polypeptide binding]; other site 1032480002230 active site 1032480002231 heme binding site [chemical binding]; other site 1032480002232 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1032480002233 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1032480002234 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1032480002235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002236 catalytic residue [active] 1032480002237 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1032480002238 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1032480002239 active site 1032480002240 Zn binding site [ion binding]; other site 1032480002241 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1032480002242 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1032480002243 EamA-like transporter family; Region: EamA; pfam00892 1032480002244 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1032480002245 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1032480002246 TPP-binding site [chemical binding]; other site 1032480002247 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1032480002248 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1032480002249 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1032480002250 dimer interface [polypeptide binding]; other site 1032480002251 PYR/PP interface [polypeptide binding]; other site 1032480002252 TPP binding site [chemical binding]; other site 1032480002253 substrate binding site [chemical binding]; other site 1032480002254 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1032480002255 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1032480002256 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1032480002257 active site 1032480002258 MarR family; Region: MarR_2; pfam12802 1032480002259 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480002260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1032480002261 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1032480002262 xylose isomerase; Provisional; Region: PRK12677 1032480002263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480002264 D-xylulose kinase; Region: XylB; TIGR01312 1032480002265 nucleotide binding site [chemical binding]; other site 1032480002266 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1032480002267 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1032480002268 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1032480002269 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1032480002270 DNA binding site [nucleotide binding] 1032480002271 active site 1032480002272 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480002273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480002274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480002275 DNA binding residues [nucleotide binding] 1032480002276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1032480002277 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1032480002278 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1032480002279 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1032480002280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480002281 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480002282 homotrimer interaction site [polypeptide binding]; other site 1032480002283 putative active site [active] 1032480002284 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1032480002285 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1032480002286 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480002287 metal binding site [ion binding]; metal-binding site 1032480002288 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1032480002289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480002290 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1032480002291 putative substrate binding pocket [chemical binding]; other site 1032480002292 dimerization interface [polypeptide binding]; other site 1032480002293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480002294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002295 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1032480002296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002297 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1032480002298 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480002299 trimer interface [polypeptide binding]; other site 1032480002300 active site 1032480002301 substrate binding site [chemical binding]; other site 1032480002302 CoA binding site [chemical binding]; other site 1032480002303 maltose O-acetyltransferase; Provisional; Region: PRK10092 1032480002304 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480002305 active site 1032480002306 substrate binding site [chemical binding]; other site 1032480002307 trimer interface [polypeptide binding]; other site 1032480002308 CoA binding site [chemical binding]; other site 1032480002309 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1032480002310 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480002311 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480002312 AAA domain; Region: AAA_22; pfam13401 1032480002313 FG-GAP repeat; Region: FG-GAP; pfam01839 1032480002314 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480002316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002317 ATP binding site [chemical binding]; other site 1032480002318 Mg2+ binding site [ion binding]; other site 1032480002319 G-X-G motif; other site 1032480002320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480002321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002322 active site 1032480002323 phosphorylation site [posttranslational modification] 1032480002324 intermolecular recognition site; other site 1032480002325 dimerization interface [polypeptide binding]; other site 1032480002326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480002327 DNA binding residues [nucleotide binding] 1032480002328 dimerization interface [polypeptide binding]; other site 1032480002329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1032480002330 FeS/SAM binding site; other site 1032480002331 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002332 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1032480002333 acyl-activating enzyme (AAE) consensus motif; other site 1032480002334 active site 1032480002335 AMP binding site [chemical binding]; other site 1032480002336 CoA binding site [chemical binding]; other site 1032480002337 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1032480002338 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002339 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1032480002340 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002341 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1032480002342 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480002343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1032480002345 active site 1032480002346 AMP binding site [chemical binding]; other site 1032480002347 acyl-activating enzyme (AAE) consensus motif; other site 1032480002348 CoA binding site [chemical binding]; other site 1032480002349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002350 acyl-activating enzyme (AAE) consensus motif; other site 1032480002351 active site 1032480002352 AMP binding site [chemical binding]; other site 1032480002353 CoA binding site [chemical binding]; other site 1032480002354 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002355 Amidase; Region: Amidase; cl11426 1032480002356 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1032480002357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1032480002359 NAD(P) binding site [chemical binding]; other site 1032480002360 active site 1032480002361 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002363 putative substrate translocation pore; other site 1032480002364 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480002365 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1032480002366 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1032480002367 active sites [active] 1032480002368 tetramer interface [polypeptide binding]; other site 1032480002369 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1032480002370 Amidase; Region: Amidase; cl11426 1032480002371 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1032480002372 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480002373 active site 1032480002374 catalytic residues [active] 1032480002375 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480002376 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 1032480002377 active site 1032480002378 catalytic site [active] 1032480002379 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1032480002380 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1032480002381 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1032480002382 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1032480002383 TIR domain; Region: TIR_2; pfam13676 1032480002384 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002386 active site 1032480002387 phosphorylation site [posttranslational modification] 1032480002388 intermolecular recognition site; other site 1032480002389 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1032480002390 active site 1032480002391 nucleophile elbow; other site 1032480002392 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1032480002393 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480002394 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1032480002395 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1032480002396 short chain dehydrogenase; Provisional; Region: PRK06940 1032480002397 classical (c) SDRs; Region: SDR_c; cd05233 1032480002398 NAD(P) binding site [chemical binding]; other site 1032480002399 active site 1032480002400 potential frameshift: common BLAST hit: gi|258652603|ref|YP_003201759.1| LuxR family transcriptional regulator 1032480002401 short chain dehydrogenase; Validated; Region: PRK05855 1032480002402 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480002403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480002404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480002405 DNA binding residues [nucleotide binding] 1032480002406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002407 S-adenosylmethionine binding site [chemical binding]; other site 1032480002408 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480002409 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480002410 NAD(P) binding site [chemical binding]; other site 1032480002411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480002412 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1032480002413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480002414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480002415 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1032480002416 putative dimerization interface [polypeptide binding]; other site 1032480002417 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1032480002418 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480002419 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480002420 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480002421 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480002422 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 1032480002423 IPT/TIG domain; Region: TIG; pfam01833 1032480002424 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480002425 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480002426 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480002427 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1032480002428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002429 NAD(P) binding site [chemical binding]; other site 1032480002430 active site 1032480002431 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1032480002432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002434 active site 1032480002435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002437 active site 1032480002438 catalytic tetrad [active] 1032480002439 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1032480002440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002441 putative substrate translocation pore; other site 1032480002442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002444 active site 1032480002445 catalytic tetrad [active] 1032480002446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002447 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1032480002448 NAD(P) binding site [chemical binding]; other site 1032480002449 active site 1032480002450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480002452 putative substrate translocation pore; other site 1032480002453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002456 active site 1032480002457 catalytic tetrad [active] 1032480002458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480002459 salt bridge; other site 1032480002460 non-specific DNA binding site [nucleotide binding]; other site 1032480002461 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480002462 sequence-specific DNA binding site [nucleotide binding]; other site 1032480002463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480002464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480002465 sequence-specific DNA binding site [nucleotide binding]; other site 1032480002466 salt bridge; other site 1032480002467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002469 active site 1032480002470 catalytic tetrad [active] 1032480002471 ApbE family; Region: ApbE; pfam02424 1032480002472 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1032480002473 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480002474 NAD(P) binding site [chemical binding]; other site 1032480002475 putative active site [active] 1032480002476 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1032480002477 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1032480002478 FAD binding pocket [chemical binding]; other site 1032480002479 conserved FAD binding motif [chemical binding]; other site 1032480002480 phosphate binding motif [ion binding]; other site 1032480002481 beta-alpha-beta structure motif; other site 1032480002482 NAD binding pocket [chemical binding]; other site 1032480002483 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1032480002484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480002485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480002486 Walker A/P-loop; other site 1032480002487 ATP binding site [chemical binding]; other site 1032480002488 Q-loop/lid; other site 1032480002489 ABC transporter signature motif; other site 1032480002490 Walker B; other site 1032480002491 D-loop; other site 1032480002492 H-loop/switch region; other site 1032480002493 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1032480002494 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480002495 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480002496 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480002497 homodimer interface [polypeptide binding]; other site 1032480002498 active site 1032480002499 TDP-binding site; other site 1032480002500 acceptor substrate-binding pocket; other site 1032480002501 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480002502 conserved cys residue [active] 1032480002503 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480002504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480002505 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480002506 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480002507 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1032480002508 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480002509 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1032480002510 putative NAD(P) binding site [chemical binding]; other site 1032480002511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002513 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480002514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480002515 CAAX protease self-immunity; Region: Abi; pfam02517 1032480002516 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1032480002517 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1032480002518 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1032480002519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480002520 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480002521 salt bridge; other site 1032480002522 non-specific DNA binding site [nucleotide binding]; other site 1032480002523 sequence-specific DNA binding site [nucleotide binding]; other site 1032480002524 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1032480002525 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480002526 catalytic Zn binding site [ion binding]; other site 1032480002527 NAD(P) binding site [chemical binding]; other site 1032480002528 structural Zn binding site [ion binding]; other site 1032480002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002530 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480002531 putative substrate translocation pore; other site 1032480002532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480002533 Coenzyme A binding pocket [chemical binding]; other site 1032480002534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002536 active site 1032480002537 catalytic tetrad [active] 1032480002538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480002539 salt bridge; other site 1032480002540 non-specific DNA binding site [nucleotide binding]; other site 1032480002541 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480002542 sequence-specific DNA binding site [nucleotide binding]; other site 1032480002543 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1032480002544 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480002545 NAD(P) binding site [chemical binding]; other site 1032480002546 hypothetical protein; Provisional; Region: PRK07550 1032480002547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480002548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002549 homodimer interface [polypeptide binding]; other site 1032480002550 catalytic residue [active] 1032480002551 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480002552 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1032480002553 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480002554 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480002555 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480002556 DNA binding site [nucleotide binding] 1032480002557 domain linker motif; other site 1032480002558 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480002559 ligand binding site [chemical binding]; other site 1032480002560 dimerization interface [polypeptide binding]; other site 1032480002561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002563 dimer interface [polypeptide binding]; other site 1032480002564 conserved gate region; other site 1032480002565 putative PBP binding loops; other site 1032480002566 ABC-ATPase subunit interface; other site 1032480002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002568 dimer interface [polypeptide binding]; other site 1032480002569 conserved gate region; other site 1032480002570 putative PBP binding loops; other site 1032480002571 ABC-ATPase subunit interface; other site 1032480002572 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480002573 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480002574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480002575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480002576 DNA binding site [nucleotide binding] 1032480002577 domain linker motif; other site 1032480002578 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480002579 dimerization interface [polypeptide binding]; other site 1032480002580 ligand binding site [chemical binding]; other site 1032480002581 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1032480002582 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1032480002583 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1032480002584 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1032480002585 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1032480002586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480002587 Transposase; Region: HTH_Tnp_1; cl17663 1032480002588 putative transposase OrfB; Reviewed; Region: PHA02517 1032480002589 HTH-like domain; Region: HTH_21; pfam13276 1032480002590 Integrase core domain; Region: rve; pfam00665 1032480002591 Integrase core domain; Region: rve_3; pfam13683 1032480002592 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1032480002593 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1032480002594 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1032480002595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002596 NAD(P) binding site [chemical binding]; other site 1032480002597 active site 1032480002598 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1032480002599 N- and C-terminal domain interface [polypeptide binding]; other site 1032480002600 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1032480002601 active site 1032480002602 putative catalytic site [active] 1032480002603 metal binding site [ion binding]; metal-binding site 1032480002604 ATP binding site [chemical binding]; other site 1032480002605 carbohydrate binding site [chemical binding]; other site 1032480002606 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480002608 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480002609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002610 active site 1032480002611 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1032480002612 active site 1032480002613 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1032480002614 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1032480002615 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1032480002616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002618 hypothetical protein; Provisional; Region: PRK07588 1032480002619 hypothetical protein; Provisional; Region: PRK07236 1032480002620 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480002621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002622 DNA-binding site [nucleotide binding]; DNA binding site 1032480002623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002625 homodimer interface [polypeptide binding]; other site 1032480002626 catalytic residue [active] 1032480002627 AAA ATPase domain; Region: AAA_16; pfam13191 1032480002628 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1032480002629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480002630 S-adenosylmethionine binding site [chemical binding]; other site 1032480002631 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1032480002632 RibD C-terminal domain; Region: RibD_C; cl17279 1032480002633 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1032480002634 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1032480002635 hexamer interface [polypeptide binding]; other site 1032480002636 ligand binding site [chemical binding]; other site 1032480002637 putative active site [active] 1032480002638 NAD(P) binding site [chemical binding]; other site 1032480002639 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1032480002640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002641 WHG domain; Region: WHG; pfam13305 1032480002642 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1032480002643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480002644 catalytic Zn binding site [ion binding]; other site 1032480002645 NAD(P) binding site [chemical binding]; other site 1032480002646 structural Zn binding site [ion binding]; other site 1032480002647 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1032480002648 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1032480002649 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1032480002650 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480002651 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480002652 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480002653 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480002654 inhibitor site; inhibition site 1032480002655 active site 1032480002656 dimer interface [polypeptide binding]; other site 1032480002657 catalytic residue [active] 1032480002658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480002659 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1032480002660 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480002661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002662 DNA-binding site [nucleotide binding]; DNA binding site 1032480002663 FCD domain; Region: FCD; pfam07729 1032480002664 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1032480002665 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1032480002666 FAD binding pocket [chemical binding]; other site 1032480002667 FAD binding motif [chemical binding]; other site 1032480002668 phosphate binding motif [ion binding]; other site 1032480002669 beta-alpha-beta structure motif; other site 1032480002670 NAD binding pocket [chemical binding]; other site 1032480002671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1032480002672 catalytic loop [active] 1032480002673 iron binding site [ion binding]; other site 1032480002674 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1032480002675 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1032480002676 [2Fe-2S] cluster binding site [ion binding]; other site 1032480002677 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1032480002678 putative alpha subunit interface [polypeptide binding]; other site 1032480002679 putative active site [active] 1032480002680 putative substrate binding site [chemical binding]; other site 1032480002681 Fe binding site [ion binding]; other site 1032480002682 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480002683 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1032480002684 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1032480002685 Walker A/P-loop; other site 1032480002686 ATP binding site [chemical binding]; other site 1032480002687 Q-loop/lid; other site 1032480002688 ABC transporter signature motif; other site 1032480002689 Walker B; other site 1032480002690 D-loop; other site 1032480002691 H-loop/switch region; other site 1032480002692 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480002693 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1032480002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002695 dimer interface [polypeptide binding]; other site 1032480002696 conserved gate region; other site 1032480002697 ABC-ATPase subunit interface; other site 1032480002698 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1032480002699 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1032480002700 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1032480002701 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1032480002702 NAD binding site [chemical binding]; other site 1032480002703 catalytic Zn binding site [ion binding]; other site 1032480002704 structural Zn binding site [ion binding]; other site 1032480002705 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480002706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002707 DNA-binding site [nucleotide binding]; DNA binding site 1032480002708 benzoate transport; Region: 2A0115; TIGR00895 1032480002709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002710 putative substrate translocation pore; other site 1032480002711 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480002712 Ligand Binding Site [chemical binding]; other site 1032480002713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002714 DNA-binding site [nucleotide binding]; DNA binding site 1032480002715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480002718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480002719 active site 1032480002720 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1032480002721 putative active site [active] 1032480002722 putative catalytic site [active] 1032480002723 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1032480002724 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1032480002725 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1032480002726 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480002727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480002728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480002729 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1032480002730 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480002731 carboxyltransferase (CT) interaction site; other site 1032480002732 biotinylation site [posttranslational modification]; other site 1032480002733 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1032480002734 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480002735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480002736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480002737 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1032480002738 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480002739 carboxyltransferase (CT) interaction site; other site 1032480002740 biotinylation site [posttranslational modification]; other site 1032480002741 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1032480002742 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1032480002743 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1032480002744 MarR family; Region: MarR_2; pfam12802 1032480002745 Cupin domain; Region: Cupin_2; pfam07883 1032480002746 WYL domain; Region: WYL; pfam13280 1032480002747 WYL domain; Region: WYL; pfam13280 1032480002748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480002751 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480002752 putative substrate translocation pore; other site 1032480002753 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1032480002754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480002755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480002756 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1032480002757 active site 1032480002758 metal binding site [ion binding]; metal-binding site 1032480002759 homotetramer interface [polypeptide binding]; other site 1032480002760 hypothetical protein; Provisional; Region: PRK06541 1032480002761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480002762 inhibitor-cofactor binding pocket; inhibition site 1032480002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002764 catalytic residue [active] 1032480002765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1032480002766 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1032480002767 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480002768 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480002769 homodimer interface [polypeptide binding]; other site 1032480002770 active site 1032480002771 TDP-binding site; other site 1032480002772 acceptor substrate-binding pocket; other site 1032480002773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480002774 catalytic core [active] 1032480002775 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480002776 active site 1032480002777 NAD synthetase; Reviewed; Region: nadE; PRK02628 1032480002778 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1032480002779 multimer interface [polypeptide binding]; other site 1032480002780 active site 1032480002781 catalytic triad [active] 1032480002782 protein interface 1 [polypeptide binding]; other site 1032480002783 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1032480002784 homodimer interface [polypeptide binding]; other site 1032480002785 NAD binding pocket [chemical binding]; other site 1032480002786 ATP binding pocket [chemical binding]; other site 1032480002787 Mg binding site [ion binding]; other site 1032480002788 active-site loop [active] 1032480002789 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480002790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480002791 NAD(P) binding site [chemical binding]; other site 1032480002792 active site 1032480002793 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1032480002794 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480002795 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480002796 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1032480002797 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1032480002798 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1032480002799 Fic family protein [Function unknown]; Region: COG3177 1032480002800 Fic/DOC family; Region: Fic; pfam02661 1032480002801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480002802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480002803 dimerization interface [polypeptide binding]; other site 1032480002804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480002805 dimer interface [polypeptide binding]; other site 1032480002806 phosphorylation site [posttranslational modification] 1032480002807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002808 ATP binding site [chemical binding]; other site 1032480002809 Mg2+ binding site [ion binding]; other site 1032480002810 G-X-G motif; other site 1032480002811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002813 active site 1032480002814 phosphorylation site [posttranslational modification] 1032480002815 intermolecular recognition site; other site 1032480002816 dimerization interface [polypeptide binding]; other site 1032480002817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480002818 DNA binding site [nucleotide binding] 1032480002819 MMPL family; Region: MMPL; pfam03176 1032480002820 MMPL family; Region: MMPL; pfam03176 1032480002821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480002822 Q-loop/lid; other site 1032480002823 ABC transporter signature motif; other site 1032480002824 Walker B; other site 1032480002825 D-loop; other site 1032480002826 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480002827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1032480002828 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1032480002829 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1032480002830 Protease prsW family; Region: PrsW-protease; pfam13367 1032480002831 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1032480002832 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1032480002833 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1032480002834 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1032480002835 putative active site [active] 1032480002836 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1032480002837 active site 1032480002838 catalytic site [active] 1032480002839 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1032480002840 active site 2 [active] 1032480002841 active site 1 [active] 1032480002842 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1032480002843 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480002844 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1032480002845 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1032480002846 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1032480002847 acyl-activating enzyme (AAE) consensus motif; other site 1032480002848 putative AMP binding site [chemical binding]; other site 1032480002849 putative active site [active] 1032480002850 putative CoA binding site [chemical binding]; other site 1032480002851 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1032480002852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480002853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480002854 homodimer interface [polypeptide binding]; other site 1032480002855 catalytic residue [active] 1032480002856 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1032480002857 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1032480002858 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1032480002859 putative homodimer interface [polypeptide binding]; other site 1032480002860 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1032480002861 heterodimer interface [polypeptide binding]; other site 1032480002862 homodimer interface [polypeptide binding]; other site 1032480002863 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1032480002864 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1032480002865 L7/L12 interface [polypeptide binding]; other site 1032480002866 23S rRNA interface [nucleotide binding]; other site 1032480002867 L25 interface [polypeptide binding]; other site 1032480002868 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1032480002869 mRNA/rRNA interface [nucleotide binding]; other site 1032480002870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480002871 Coenzyme A binding pocket [chemical binding]; other site 1032480002872 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1032480002873 NlpC/P60 family; Region: NLPC_P60; cl17555 1032480002874 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1032480002875 23S rRNA interface [nucleotide binding]; other site 1032480002876 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1032480002877 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1032480002878 core dimer interface [polypeptide binding]; other site 1032480002879 peripheral dimer interface [polypeptide binding]; other site 1032480002880 L10 interface [polypeptide binding]; other site 1032480002881 L11 interface [polypeptide binding]; other site 1032480002882 putative EF-Tu interaction site [polypeptide binding]; other site 1032480002883 putative EF-G interaction site [polypeptide binding]; other site 1032480002884 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1032480002885 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1032480002886 Walker A/P-loop; other site 1032480002887 ATP binding site [chemical binding]; other site 1032480002888 Q-loop/lid; other site 1032480002889 ABC transporter signature motif; other site 1032480002890 Walker B; other site 1032480002891 D-loop; other site 1032480002892 H-loop/switch region; other site 1032480002893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480002894 dimer interface [polypeptide binding]; other site 1032480002895 conserved gate region; other site 1032480002896 putative PBP binding loops; other site 1032480002897 ABC-ATPase subunit interface; other site 1032480002898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480002899 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1032480002900 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480002901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480002902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480002903 active site 1032480002904 phosphorylation site [posttranslational modification] 1032480002905 intermolecular recognition site; other site 1032480002906 dimerization interface [polypeptide binding]; other site 1032480002907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480002908 DNA binding residues [nucleotide binding] 1032480002909 dimerization interface [polypeptide binding]; other site 1032480002910 Histidine kinase; Region: HisKA_3; pfam07730 1032480002911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480002912 ATP binding site [chemical binding]; other site 1032480002913 Mg2+ binding site [ion binding]; other site 1032480002914 G-X-G motif; other site 1032480002915 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1032480002916 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1032480002917 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1032480002918 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1032480002919 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1032480002920 RPB1 interaction site [polypeptide binding]; other site 1032480002921 RPB10 interaction site [polypeptide binding]; other site 1032480002922 RPB11 interaction site [polypeptide binding]; other site 1032480002923 RPB3 interaction site [polypeptide binding]; other site 1032480002924 RPB12 interaction site [polypeptide binding]; other site 1032480002925 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1032480002926 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1032480002927 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1032480002928 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1032480002929 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1032480002930 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1032480002931 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1032480002932 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1032480002933 G-loop; other site 1032480002934 DNA binding site [nucleotide binding] 1032480002935 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480002936 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480002937 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480002938 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1032480002939 TM-ABC transporter signature motif; other site 1032480002940 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1032480002941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480002942 Walker A/P-loop; other site 1032480002943 ATP binding site [chemical binding]; other site 1032480002944 Q-loop/lid; other site 1032480002945 ABC transporter signature motif; other site 1032480002946 Walker B; other site 1032480002947 D-loop; other site 1032480002948 H-loop/switch region; other site 1032480002949 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1032480002950 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480002951 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1032480002952 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480002953 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1032480002954 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1032480002955 putative N- and C-terminal domain interface [polypeptide binding]; other site 1032480002956 putative active site [active] 1032480002957 MgATP binding site [chemical binding]; other site 1032480002958 catalytic site [active] 1032480002959 metal binding site [ion binding]; metal-binding site 1032480002960 putative xylulose binding site [chemical binding]; other site 1032480002961 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480002962 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480002963 NAD(P) binding site [chemical binding]; other site 1032480002964 Ankyrin repeat; Region: Ank; pfam00023 1032480002965 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002966 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002967 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002968 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002969 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480002970 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480002971 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480002972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480002973 DNA-binding site [nucleotide binding]; DNA binding site 1032480002974 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1032480002975 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480002976 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480002977 active site 1032480002978 catalytic tetrad [active] 1032480002979 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1032480002980 S17 interaction site [polypeptide binding]; other site 1032480002981 S8 interaction site; other site 1032480002982 16S rRNA interaction site [nucleotide binding]; other site 1032480002983 streptomycin interaction site [chemical binding]; other site 1032480002984 23S rRNA interaction site [nucleotide binding]; other site 1032480002985 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1032480002986 30S ribosomal protein S7; Validated; Region: PRK05302 1032480002987 elongation factor G; Reviewed; Region: PRK00007 1032480002988 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1032480002989 G1 box; other site 1032480002990 putative GEF interaction site [polypeptide binding]; other site 1032480002991 GTP/Mg2+ binding site [chemical binding]; other site 1032480002992 Switch I region; other site 1032480002993 G2 box; other site 1032480002994 G3 box; other site 1032480002995 Switch II region; other site 1032480002996 G4 box; other site 1032480002997 G5 box; other site 1032480002998 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1032480002999 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1032480003000 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1032480003001 elongation factor Tu; Reviewed; Region: PRK00049 1032480003002 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1032480003003 G1 box; other site 1032480003004 GEF interaction site [polypeptide binding]; other site 1032480003005 GTP/Mg2+ binding site [chemical binding]; other site 1032480003006 Switch I region; other site 1032480003007 G2 box; other site 1032480003008 G3 box; other site 1032480003009 Switch II region; other site 1032480003010 G4 box; other site 1032480003011 G5 box; other site 1032480003012 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1032480003013 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1032480003014 Antibiotic Binding Site [chemical binding]; other site 1032480003015 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1032480003016 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1032480003017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480003018 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1032480003019 Walker A/P-loop; other site 1032480003020 ATP binding site [chemical binding]; other site 1032480003021 Q-loop/lid; other site 1032480003022 ABC transporter signature motif; other site 1032480003023 Walker B; other site 1032480003024 D-loop; other site 1032480003025 H-loop/switch region; other site 1032480003026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480003027 Histidine kinase; Region: HisKA_3; pfam07730 1032480003028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480003029 ATP binding site [chemical binding]; other site 1032480003030 Mg2+ binding site [ion binding]; other site 1032480003031 G-X-G motif; other site 1032480003032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480003033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003034 active site 1032480003035 phosphorylation site [posttranslational modification] 1032480003036 intermolecular recognition site; other site 1032480003037 dimerization interface [polypeptide binding]; other site 1032480003038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480003039 DNA binding residues [nucleotide binding] 1032480003040 dimerization interface [polypeptide binding]; other site 1032480003041 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1032480003042 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1032480003043 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1032480003044 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1032480003045 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1032480003046 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1032480003047 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1032480003048 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1032480003049 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1032480003050 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1032480003051 putative translocon binding site; other site 1032480003052 protein-rRNA interface [nucleotide binding]; other site 1032480003053 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1032480003054 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1032480003055 G-X-X-G motif; other site 1032480003056 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1032480003057 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1032480003058 23S rRNA interface [nucleotide binding]; other site 1032480003059 5S rRNA interface [nucleotide binding]; other site 1032480003060 putative antibiotic binding site [chemical binding]; other site 1032480003061 L25 interface [polypeptide binding]; other site 1032480003062 L27 interface [polypeptide binding]; other site 1032480003063 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1032480003064 23S rRNA interface [nucleotide binding]; other site 1032480003065 putative translocon interaction site; other site 1032480003066 signal recognition particle (SRP54) interaction site; other site 1032480003067 L23 interface [polypeptide binding]; other site 1032480003068 trigger factor interaction site; other site 1032480003069 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1032480003070 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1032480003071 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1032480003072 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1032480003073 RNA binding site [nucleotide binding]; other site 1032480003074 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1032480003075 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1032480003076 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1032480003077 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1032480003078 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1032480003079 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1032480003080 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1032480003081 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1032480003082 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1032480003083 5S rRNA interface [nucleotide binding]; other site 1032480003084 L27 interface [polypeptide binding]; other site 1032480003085 23S rRNA interface [nucleotide binding]; other site 1032480003086 L5 interface [polypeptide binding]; other site 1032480003087 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1032480003088 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1032480003089 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1032480003090 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1032480003091 23S rRNA binding site [nucleotide binding]; other site 1032480003092 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1032480003093 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1032480003094 SecY translocase; Region: SecY; pfam00344 1032480003095 adenylate kinase; Reviewed; Region: adk; PRK00279 1032480003096 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1032480003097 AMP-binding site [chemical binding]; other site 1032480003098 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1032480003099 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480003100 active site 1032480003101 TIGR03086 family protein; Region: TIGR03086 1032480003102 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1032480003103 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480003104 hydrophobic ligand binding site; other site 1032480003105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480003106 dimerization interface [polypeptide binding]; other site 1032480003107 putative DNA binding site [nucleotide binding]; other site 1032480003108 putative Zn2+ binding site [ion binding]; other site 1032480003109 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1032480003110 dimerization interface [polypeptide binding]; other site 1032480003111 substrate binding pocket [chemical binding]; other site 1032480003112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480003113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480003114 non-specific DNA binding site [nucleotide binding]; other site 1032480003115 salt bridge; other site 1032480003116 sequence-specific DNA binding site [nucleotide binding]; other site 1032480003117 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1032480003118 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480003119 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480003120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480003121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480003122 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480003123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480003124 active site 1032480003125 ATP binding site [chemical binding]; other site 1032480003126 substrate binding site [chemical binding]; other site 1032480003127 activation loop (A-loop); other site 1032480003128 CRISPR-associated protein; Region: TIGR03986 1032480003129 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1032480003130 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480003131 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 1032480003132 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480003133 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 1032480003134 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480003135 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1032480003136 NTP binding site [chemical binding]; other site 1032480003137 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1032480003138 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1032480003139 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1032480003140 CRISPR-associated protein; Region: TIGR03986 1032480003141 CRISPR-associated protein; Region: TIGR03986 1032480003142 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1032480003143 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480003144 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1032480003145 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480003146 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1032480003147 Probable galactinol--sucrose galactosyltransferase; Region: PLN02711 1032480003148 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1032480003149 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1032480003150 cofactor binding site; other site 1032480003151 DNA binding site [nucleotide binding] 1032480003152 substrate interaction site [chemical binding]; other site 1032480003153 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1032480003154 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1032480003155 additional DNA contacts [nucleotide binding]; other site 1032480003156 mismatch recognition site; other site 1032480003157 active site 1032480003158 zinc binding site [ion binding]; other site 1032480003159 DNA intercalation site [nucleotide binding]; other site 1032480003160 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1032480003161 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1032480003162 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480003163 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1032480003164 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1032480003165 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1032480003166 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1032480003167 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1032480003168 active site 1032480003169 catalytic site [active] 1032480003170 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1032480003171 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1032480003172 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1032480003173 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1032480003174 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480003175 Divergent AAA domain; Region: AAA_4; pfam04326 1032480003176 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1032480003177 rRNA binding site [nucleotide binding]; other site 1032480003178 predicted 30S ribosome binding site; other site 1032480003179 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1032480003180 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1032480003181 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1032480003182 30S ribosomal protein S11; Validated; Region: PRK05309 1032480003183 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1032480003184 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1032480003185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480003186 RNA binding surface [nucleotide binding]; other site 1032480003187 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1032480003188 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1032480003189 alphaNTD - beta interaction site [polypeptide binding]; other site 1032480003190 alphaNTD homodimer interface [polypeptide binding]; other site 1032480003191 alphaNTD - beta' interaction site [polypeptide binding]; other site 1032480003192 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1032480003193 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1032480003194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480003195 motif II; other site 1032480003196 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480003197 putative hydrophobic ligand binding site [chemical binding]; other site 1032480003198 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480003199 hydrophobic ligand binding site; other site 1032480003200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480003201 dimerization interface [polypeptide binding]; other site 1032480003202 putative DNA binding site [nucleotide binding]; other site 1032480003203 putative Zn2+ binding site [ion binding]; other site 1032480003204 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480003205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480003206 Walker A/P-loop; other site 1032480003207 ATP binding site [chemical binding]; other site 1032480003208 Q-loop/lid; other site 1032480003209 ABC transporter signature motif; other site 1032480003210 Walker B; other site 1032480003211 D-loop; other site 1032480003212 H-loop/switch region; other site 1032480003213 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480003214 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480003215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480003216 Walker A/P-loop; other site 1032480003217 ATP binding site [chemical binding]; other site 1032480003218 Q-loop/lid; other site 1032480003219 ABC transporter signature motif; other site 1032480003220 Walker B; other site 1032480003221 D-loop; other site 1032480003222 H-loop/switch region; other site 1032480003223 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1032480003224 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480003225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003226 putative PBP binding loops; other site 1032480003227 ABC-ATPase subunit interface; other site 1032480003228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480003229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003230 dimer interface [polypeptide binding]; other site 1032480003231 conserved gate region; other site 1032480003232 putative PBP binding loops; other site 1032480003233 ABC-ATPase subunit interface; other site 1032480003234 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1032480003235 substrate binding site [chemical binding]; other site 1032480003236 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1032480003237 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1032480003238 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1032480003239 active site 1032480003240 DNA binding site [nucleotide binding] 1032480003241 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1032480003242 DNA binding site [nucleotide binding] 1032480003243 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1032480003244 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1032480003245 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1032480003246 oligomer interface [polypeptide binding]; other site 1032480003247 metal binding site [ion binding]; metal-binding site 1032480003248 metal binding site [ion binding]; metal-binding site 1032480003249 putative Cl binding site [ion binding]; other site 1032480003250 aspartate ring; other site 1032480003251 basic sphincter; other site 1032480003252 hydrophobic gate; other site 1032480003253 periplasmic entrance; other site 1032480003254 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1032480003255 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1032480003256 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1032480003257 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1032480003258 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1032480003259 Walker A/P-loop; other site 1032480003260 ATP binding site [chemical binding]; other site 1032480003261 Q-loop/lid; other site 1032480003262 ABC transporter signature motif; other site 1032480003263 Walker B; other site 1032480003264 D-loop; other site 1032480003265 H-loop/switch region; other site 1032480003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003267 S-adenosylmethionine binding site [chemical binding]; other site 1032480003268 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1032480003269 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1032480003270 dimerization interface 3.5A [polypeptide binding]; other site 1032480003271 active site 1032480003272 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1032480003273 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480003274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480003275 Walker A/P-loop; other site 1032480003276 ATP binding site [chemical binding]; other site 1032480003277 Q-loop/lid; other site 1032480003278 ABC transporter signature motif; other site 1032480003279 Walker B; other site 1032480003280 D-loop; other site 1032480003281 H-loop/switch region; other site 1032480003282 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1032480003283 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480003284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480003285 Walker A/P-loop; other site 1032480003286 ATP binding site [chemical binding]; other site 1032480003287 Q-loop/lid; other site 1032480003288 ABC transporter signature motif; other site 1032480003289 Walker B; other site 1032480003290 D-loop; other site 1032480003291 H-loop/switch region; other site 1032480003292 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480003293 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1032480003294 Citrate synthase; Region: Citrate_synt; pfam00285 1032480003295 oxalacetate binding site [chemical binding]; other site 1032480003296 citrylCoA binding site [chemical binding]; other site 1032480003297 coenzyme A binding site [chemical binding]; other site 1032480003298 catalytic triad [active] 1032480003299 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1032480003300 23S rRNA interface [nucleotide binding]; other site 1032480003301 L3 interface [polypeptide binding]; other site 1032480003302 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1032480003303 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1032480003304 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1032480003305 active site 1032480003306 substrate binding site [chemical binding]; other site 1032480003307 metal binding site [ion binding]; metal-binding site 1032480003308 pantothenate kinase; Provisional; Region: PRK05439 1032480003309 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1032480003310 ATP-binding site [chemical binding]; other site 1032480003311 CoA-binding site [chemical binding]; other site 1032480003312 Mg2+-binding site [ion binding]; other site 1032480003313 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1032480003314 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1032480003315 glutaminase active site [active] 1032480003316 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480003317 dimer interface [polypeptide binding]; other site 1032480003318 active site 1032480003319 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480003320 dimer interface [polypeptide binding]; other site 1032480003321 active site 1032480003322 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1032480003323 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1032480003324 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1032480003325 alanine racemase; Reviewed; Region: alr; PRK00053 1032480003326 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1032480003327 active site 1032480003328 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480003329 dimer interface [polypeptide binding]; other site 1032480003330 substrate binding site [chemical binding]; other site 1032480003331 catalytic residues [active] 1032480003332 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480003333 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1032480003334 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1032480003335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480003336 motif II; other site 1032480003337 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1032480003338 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480003339 ATP binding site [chemical binding]; other site 1032480003340 Mg++ binding site [ion binding]; other site 1032480003341 motif III; other site 1032480003342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480003343 nucleotide binding region [chemical binding]; other site 1032480003344 ATP-binding site [chemical binding]; other site 1032480003345 putative acetyltransferase; Provisional; Region: PRK03624 1032480003346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480003347 Coenzyme A binding pocket [chemical binding]; other site 1032480003348 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1032480003349 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1032480003350 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480003351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003352 S-adenosylmethionine binding site [chemical binding]; other site 1032480003353 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480003354 CoenzymeA binding site [chemical binding]; other site 1032480003355 subunit interaction site [polypeptide binding]; other site 1032480003356 PHB binding site; other site 1032480003357 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1032480003358 oligomerisation interface [polypeptide binding]; other site 1032480003359 mobile loop; other site 1032480003360 roof hairpin; other site 1032480003361 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1032480003362 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1032480003363 ring oligomerisation interface [polypeptide binding]; other site 1032480003364 ATP/Mg binding site [chemical binding]; other site 1032480003365 stacking interactions; other site 1032480003366 hinge regions; other site 1032480003367 Integrase core domain; Region: rve; pfam00665 1032480003368 Integrase core domain; Region: rve_3; pfam13683 1032480003369 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1032480003370 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1032480003371 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1032480003372 active site 1032480003373 Zn binding site [ion binding]; other site 1032480003374 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1032480003375 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1032480003376 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1032480003377 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1032480003378 active site 1032480003379 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1032480003380 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1032480003381 phosphate binding site [ion binding]; other site 1032480003382 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480003383 Subtilisin inhibitor-like; Region: SSI; cl11594 1032480003384 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 1032480003385 active site 1032480003386 catalytic triad [active] 1032480003387 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 1032480003388 PA/protease or protease-like domain interface [polypeptide binding]; other site 1032480003389 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1032480003390 chorismate mutase; Provisional; Region: PRK09239 1032480003391 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1032480003392 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480003393 NAD(P) binding site [chemical binding]; other site 1032480003394 catalytic residues [active] 1032480003395 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480003396 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1032480003397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480003398 Coenzyme A binding pocket [chemical binding]; other site 1032480003399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480003400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480003401 non-specific DNA binding site [nucleotide binding]; other site 1032480003402 sequence-specific DNA binding site [nucleotide binding]; other site 1032480003403 salt bridge; other site 1032480003404 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1032480003405 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1032480003406 GMP synthase; Reviewed; Region: guaA; PRK00074 1032480003407 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1032480003408 AMP/PPi binding site [chemical binding]; other site 1032480003409 candidate oxyanion hole; other site 1032480003410 catalytic triad [active] 1032480003411 potential glutamine specificity residues [chemical binding]; other site 1032480003412 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1032480003413 ATP Binding subdomain [chemical binding]; other site 1032480003414 Ligand Binding sites [chemical binding]; other site 1032480003415 Dimerization subdomain; other site 1032480003416 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480003417 PspC domain; Region: PspC; pfam04024 1032480003418 PspC domain; Region: PspC; pfam04024 1032480003419 PspC domain; Region: PspC; pfam04024 1032480003420 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480003421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003422 active site 1032480003423 phosphorylation site [posttranslational modification] 1032480003424 intermolecular recognition site; other site 1032480003425 dimerization interface [polypeptide binding]; other site 1032480003426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480003427 DNA binding residues [nucleotide binding] 1032480003428 dimerization interface [polypeptide binding]; other site 1032480003429 Predicted transcriptional regulator [Transcription]; Region: COG1959 1032480003430 Transcriptional regulator; Region: Rrf2; pfam02082 1032480003431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480003432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1032480003433 dimer interface [polypeptide binding]; other site 1032480003434 putative metal binding site [ion binding]; other site 1032480003435 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 1032480003436 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003437 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003438 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003439 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003440 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480003441 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003442 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003443 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480003444 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1032480003445 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1032480003446 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1032480003447 phosphate binding site [ion binding]; other site 1032480003448 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1032480003449 PLD-like domain; Region: PLDc_2; pfam13091 1032480003450 putative active site [active] 1032480003451 catalytic site [active] 1032480003452 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1032480003453 PLD-like domain; Region: PLDc_2; pfam13091 1032480003454 putative active site [active] 1032480003455 catalytic site [active] 1032480003456 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1032480003457 Part of AAA domain; Region: AAA_19; pfam13245 1032480003458 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1032480003459 Family description; Region: UvrD_C_2; pfam13538 1032480003460 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480003461 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003462 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480003463 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003464 Lipase (class 2); Region: Lipase_2; pfam01674 1032480003465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480003466 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1032480003467 B12 binding site [chemical binding]; other site 1032480003468 cobalt ligand [ion binding]; other site 1032480003469 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1032480003470 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1032480003471 CoA-ligase; Region: Ligase_CoA; pfam00549 1032480003472 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1032480003473 CoA binding domain; Region: CoA_binding; smart00881 1032480003474 CoA-ligase; Region: Ligase_CoA; pfam00549 1032480003475 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1032480003476 dimer interface [polypeptide binding]; other site 1032480003477 ADP-ribose binding site [chemical binding]; other site 1032480003478 active site 1032480003479 nudix motif; other site 1032480003480 metal binding site [ion binding]; metal-binding site 1032480003481 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1032480003482 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1032480003483 G1 box; other site 1032480003484 GTP/Mg2+ binding site [chemical binding]; other site 1032480003485 G2 box; other site 1032480003486 Switch I region; other site 1032480003487 G3 box; other site 1032480003488 Switch II region; other site 1032480003489 G4 box; other site 1032480003490 G5 box; other site 1032480003491 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1032480003492 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1032480003493 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1032480003494 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1032480003495 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1032480003496 active site 1032480003497 substrate binding site [chemical binding]; other site 1032480003498 cosubstrate binding site; other site 1032480003499 catalytic site [active] 1032480003500 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1032480003501 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1032480003502 purine monophosphate binding site [chemical binding]; other site 1032480003503 dimer interface [polypeptide binding]; other site 1032480003504 putative catalytic residues [active] 1032480003505 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1032480003506 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1032480003507 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1032480003508 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1032480003509 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1032480003510 homodimer interface [polypeptide binding]; other site 1032480003511 NADP binding site [chemical binding]; other site 1032480003512 substrate binding site [chemical binding]; other site 1032480003513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480003514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003515 active site 1032480003516 phosphorylation site [posttranslational modification] 1032480003517 intermolecular recognition site; other site 1032480003518 dimerization interface [polypeptide binding]; other site 1032480003519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480003520 DNA binding residues [nucleotide binding] 1032480003521 dimerization interface [polypeptide binding]; other site 1032480003522 Histidine kinase; Region: HisKA_3; pfam07730 1032480003523 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480003524 ATP binding site [chemical binding]; other site 1032480003525 Mg2+ binding site [ion binding]; other site 1032480003526 G-X-G motif; other site 1032480003527 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1032480003528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480003529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480003530 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1032480003531 metal binding site [ion binding]; metal-binding site 1032480003532 dimer interface [polypeptide binding]; other site 1032480003533 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1032480003534 malate dehydrogenase; Provisional; Region: PRK05442 1032480003535 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1032480003536 NAD(P) binding site [chemical binding]; other site 1032480003537 dimer interface [polypeptide binding]; other site 1032480003538 malate binding site [chemical binding]; other site 1032480003539 hypothetical protein; Provisional; Region: PRK06547 1032480003540 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1032480003541 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1032480003542 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480003543 putative active site [active] 1032480003544 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1032480003545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480003546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480003547 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 1032480003548 substrate binding pocket [chemical binding]; other site 1032480003549 dimerization interface [polypeptide binding]; other site 1032480003550 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1032480003551 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1032480003552 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1032480003553 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1032480003554 active site 1032480003555 catalytic site [active] 1032480003556 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480003557 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480003558 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1032480003559 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480003560 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480003561 NAD(P) binding site [chemical binding]; other site 1032480003562 shikimate binding site; other site 1032480003563 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1032480003564 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1032480003565 trimer interface [polypeptide binding]; other site 1032480003566 active site 1032480003567 dimer interface [polypeptide binding]; other site 1032480003568 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1032480003569 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1032480003570 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480003571 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1032480003572 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1032480003573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1032480003574 active site 1032480003575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003576 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480003577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480003579 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1032480003580 Domain of unknown function DUF21; Region: DUF21; pfam01595 1032480003581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1032480003582 Transporter associated domain; Region: CorC_HlyC; smart01091 1032480003583 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1032480003584 active site 1032480003585 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1032480003586 HIGH motif; other site 1032480003587 dimer interface [polypeptide binding]; other site 1032480003588 KMSKS motif; other site 1032480003589 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1032480003590 catalytic triad [active] 1032480003591 conserved cis-peptide bond; other site 1032480003592 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480003593 active site 1032480003594 metal binding site [ion binding]; metal-binding site 1032480003595 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1032480003596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480003597 ATP binding site [chemical binding]; other site 1032480003598 putative Mg++ binding site [ion binding]; other site 1032480003599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480003600 nucleotide binding region [chemical binding]; other site 1032480003601 ATP-binding site [chemical binding]; other site 1032480003602 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480003603 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480003604 active site 1032480003605 ATP binding site [chemical binding]; other site 1032480003606 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003607 substrate binding site [chemical binding]; other site 1032480003608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480003609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480003610 active site 1032480003611 phosphorylation site [posttranslational modification] 1032480003612 intermolecular recognition site; other site 1032480003613 dimerization interface [polypeptide binding]; other site 1032480003614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480003615 DNA binding site [nucleotide binding] 1032480003616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480003617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480003618 dimerization interface [polypeptide binding]; other site 1032480003619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480003620 dimer interface [polypeptide binding]; other site 1032480003621 phosphorylation site [posttranslational modification] 1032480003622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480003623 ATP binding site [chemical binding]; other site 1032480003624 Mg2+ binding site [ion binding]; other site 1032480003625 G-X-G motif; other site 1032480003626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480003627 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480003628 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1032480003629 active site 1032480003630 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1032480003631 classical (c) SDRs; Region: SDR_c; cd05233 1032480003632 NAD(P) binding site [chemical binding]; other site 1032480003633 active site 1032480003634 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480003635 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480003636 Walker A/P-loop; other site 1032480003637 ATP binding site [chemical binding]; other site 1032480003638 Q-loop/lid; other site 1032480003639 ABC transporter signature motif; other site 1032480003640 Walker B; other site 1032480003641 D-loop; other site 1032480003642 H-loop/switch region; other site 1032480003643 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480003644 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1032480003645 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480003646 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480003647 FAD binding pocket [chemical binding]; other site 1032480003648 FAD binding motif [chemical binding]; other site 1032480003649 phosphate binding motif [ion binding]; other site 1032480003650 NAD binding pocket [chemical binding]; other site 1032480003651 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1032480003652 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1032480003653 metal binding site [ion binding]; metal-binding site 1032480003654 putative dimer interface [polypeptide binding]; other site 1032480003655 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1032480003656 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480003657 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1032480003658 putative active site [active] 1032480003659 catalytic site [active] 1032480003660 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1032480003661 putative active site [active] 1032480003662 catalytic site [active] 1032480003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003664 S-adenosylmethionine binding site [chemical binding]; other site 1032480003665 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480003666 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480003667 putative catalytic site [active] 1032480003668 putative metal binding site [ion binding]; other site 1032480003669 putative phosphate binding site [ion binding]; other site 1032480003670 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480003671 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1032480003672 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1032480003673 active site 1032480003674 HIGH motif; other site 1032480003675 KMSKS motif; other site 1032480003676 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1032480003677 tRNA binding surface [nucleotide binding]; other site 1032480003678 anticodon binding site; other site 1032480003679 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1032480003680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003681 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480003682 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480003683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480003684 S-adenosylmethionine binding site [chemical binding]; other site 1032480003685 prephenate dehydratase; Provisional; Region: PRK11899 1032480003686 Prephenate dehydratase; Region: PDT; pfam00800 1032480003687 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1032480003688 putative L-Phe binding site [chemical binding]; other site 1032480003689 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1032480003690 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1032480003691 homodimer interface [polypeptide binding]; other site 1032480003692 substrate-cofactor binding pocket; other site 1032480003693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003694 catalytic residue [active] 1032480003695 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1032480003696 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1032480003697 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480003698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480003699 active site 1032480003700 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480003701 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480003702 active site 1032480003703 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1032480003704 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1032480003705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480003706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480003707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480003708 active site 1032480003709 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1032480003710 tetramer interface [polypeptide binding]; other site 1032480003711 TPP-binding site [chemical binding]; other site 1032480003712 heterodimer interface [polypeptide binding]; other site 1032480003713 phosphorylation loop region [posttranslational modification] 1032480003714 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1032480003715 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1032480003716 PYR/PP interface [polypeptide binding]; other site 1032480003717 dimer interface [polypeptide binding]; other site 1032480003718 TPP binding site [chemical binding]; other site 1032480003719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003720 L-lysine aminotransferase; Provisional; Region: PRK08297 1032480003721 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480003722 inhibitor-cofactor binding pocket; inhibition site 1032480003723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003724 catalytic residue [active] 1032480003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1032480003726 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480003727 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1032480003728 putative active site pocket [active] 1032480003729 dimerization interface [polypeptide binding]; other site 1032480003730 putative catalytic residue [active] 1032480003731 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1032480003732 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1032480003733 NAD binding site [chemical binding]; other site 1032480003734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480003735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480003736 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480003737 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480003738 NAD-dependent deacetylase; Provisional; Region: PRK00481 1032480003739 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1032480003740 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480003741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480003742 DNA-binding site [nucleotide binding]; DNA binding site 1032480003743 FCD domain; Region: FCD; pfam07729 1032480003744 GntP family permease; Region: GntP_permease; pfam02447 1032480003745 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1032480003746 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1032480003747 AAA domain; Region: AAA_33; pfam13671 1032480003748 ATP-binding site [chemical binding]; other site 1032480003749 Gluconate-6-phosphate binding site [chemical binding]; other site 1032480003750 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1032480003751 classical (c) SDRs; Region: SDR_c; cd05233 1032480003752 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1032480003753 NAD(P) binding site [chemical binding]; other site 1032480003754 active site 1032480003755 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480003756 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480003757 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1032480003758 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1032480003759 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480003760 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1032480003761 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1032480003762 potential frameshift: common BLAST hit: gi|134101169|ref|YP_001106830.1| oxidoreductase 1032480003763 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480003764 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480003765 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480003766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480003767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480003768 DNA binding site [nucleotide binding] 1032480003769 domain linker motif; other site 1032480003770 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480003771 ligand binding site [chemical binding]; other site 1032480003772 dimerization interface [polypeptide binding]; other site 1032480003773 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480003774 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1032480003775 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480003776 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1032480003777 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1032480003778 Maf-like protein; Region: Maf; pfam02545 1032480003779 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1032480003780 active site 1032480003781 dimer interface [polypeptide binding]; other site 1032480003782 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480003783 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480003784 active site 1032480003785 catalytic site [active] 1032480003786 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480003787 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480003788 active site 1032480003789 catalytic site [active] 1032480003790 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1032480003791 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1032480003792 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1032480003793 Bacterial PH domain; Region: DUF304; pfam03703 1032480003794 Predicted membrane protein [Function unknown]; Region: COG2246 1032480003795 GtrA-like protein; Region: GtrA; pfam04138 1032480003796 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1032480003797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003798 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1032480003799 ATP-grasp domain; Region: ATP-grasp; pfam02222 1032480003800 AIR carboxylase; Region: AIRC; pfam00731 1032480003801 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1032480003802 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1032480003803 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003804 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480003805 active site 1032480003806 ATP binding site [chemical binding]; other site 1032480003807 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1032480003808 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1032480003809 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1032480003810 potential frameshift: common BLAST hit: gi|162456351|ref|YP_001618718.1| transposase 1032480003811 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480003812 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1032480003813 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1032480003814 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1032480003815 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1032480003816 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1032480003817 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480003818 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480003819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003821 dimer interface [polypeptide binding]; other site 1032480003822 conserved gate region; other site 1032480003823 putative PBP binding loops; other site 1032480003824 ABC-ATPase subunit interface; other site 1032480003825 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1032480003826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480003828 dimer interface [polypeptide binding]; other site 1032480003829 conserved gate region; other site 1032480003830 putative PBP binding loops; other site 1032480003831 ABC-ATPase subunit interface; other site 1032480003832 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480003833 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480003834 Walker A/P-loop; other site 1032480003835 ATP binding site [chemical binding]; other site 1032480003836 Q-loop/lid; other site 1032480003837 ABC transporter signature motif; other site 1032480003838 Walker B; other site 1032480003839 D-loop; other site 1032480003840 H-loop/switch region; other site 1032480003841 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480003842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480003843 Walker A/P-loop; other site 1032480003844 ATP binding site [chemical binding]; other site 1032480003845 Q-loop/lid; other site 1032480003846 ABC transporter signature motif; other site 1032480003847 Walker B; other site 1032480003848 D-loop; other site 1032480003849 H-loop/switch region; other site 1032480003850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480003851 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1032480003852 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1032480003853 active site 1032480003854 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480003855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480003856 DNA-binding site [nucleotide binding]; DNA binding site 1032480003857 FCD domain; Region: FCD; pfam07729 1032480003858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003859 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480003860 putative substrate translocation pore; other site 1032480003861 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1032480003862 putative active site [active] 1032480003863 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1032480003864 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1032480003865 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1032480003866 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480003867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480003868 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1032480003869 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1032480003870 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480003871 carboxyltransferase (CT) interaction site; other site 1032480003872 biotinylation site [posttranslational modification]; other site 1032480003873 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1032480003874 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1032480003875 dimerization interface [polypeptide binding]; other site 1032480003876 ligand binding site [chemical binding]; other site 1032480003877 NADP binding site [chemical binding]; other site 1032480003878 catalytic site [active] 1032480003879 aspartate aminotransferase; Provisional; Region: PRK05764 1032480003880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480003881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480003882 homodimer interface [polypeptide binding]; other site 1032480003883 catalytic residue [active] 1032480003884 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1032480003885 ligand binding site [chemical binding]; other site 1032480003886 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480003887 phosphopeptide binding site; other site 1032480003888 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1032480003889 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1032480003890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480003891 Walker A motif; other site 1032480003892 ATP binding site [chemical binding]; other site 1032480003893 Walker B motif; other site 1032480003894 hypothetical protein; Provisional; Region: PRK07236 1032480003895 hypothetical protein; Provisional; Region: PRK07588 1032480003896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003897 putative substrate translocation pore; other site 1032480003898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480003899 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480003900 MarR family; Region: MarR; pfam01047 1032480003901 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1032480003902 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1032480003903 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480003904 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1032480003905 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1032480003906 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480003907 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480003908 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480003909 RHS Repeat; Region: RHS_repeat; cl11982 1032480003910 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480003911 RHS Repeat; Region: RHS_repeat; pfam05593 1032480003912 RHS Repeat; Region: RHS_repeat; pfam05593 1032480003913 RHS Repeat; Region: RHS_repeat; pfam05593 1032480003914 RHS Repeat; Region: RHS_repeat; pfam05593 1032480003915 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1032480003916 RHS Repeat; Region: RHS_repeat; pfam05593 1032480003917 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480003918 PIN domain; Region: PIN; pfam01850 1032480003919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480003920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480003921 active site 1032480003922 ATP binding site [chemical binding]; other site 1032480003923 substrate binding site [chemical binding]; other site 1032480003924 activation loop (A-loop); other site 1032480003925 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1032480003926 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1032480003927 iron-sulfur cluster [ion binding]; other site 1032480003928 [2Fe-2S] cluster binding site [ion binding]; other site 1032480003929 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480003930 putative active site [active] 1032480003931 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1032480003932 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1032480003933 GIY-YIG motif/motif A; other site 1032480003934 active site 1032480003935 catalytic site [active] 1032480003936 putative DNA binding site [nucleotide binding]; other site 1032480003937 metal binding site [ion binding]; metal-binding site 1032480003938 UvrB/uvrC motif; Region: UVR; pfam02151 1032480003939 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1032480003940 Helix-hairpin-helix motif; Region: HHH; pfam00633 1032480003941 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1032480003942 shikimate kinase; Reviewed; Region: aroK; PRK00131 1032480003943 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1032480003944 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1032480003945 putative substrate binding pocket [chemical binding]; other site 1032480003946 dimer interface [polypeptide binding]; other site 1032480003947 phosphate binding site [ion binding]; other site 1032480003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1032480003949 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1032480003950 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1032480003951 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1032480003952 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1032480003953 Phosphoglycerate kinase; Region: PGK; pfam00162 1032480003954 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1032480003955 substrate binding site [chemical binding]; other site 1032480003956 hinge regions; other site 1032480003957 ADP binding site [chemical binding]; other site 1032480003958 catalytic site [active] 1032480003959 triosephosphate isomerase; Provisional; Region: PRK14567 1032480003960 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1032480003961 substrate binding site [chemical binding]; other site 1032480003962 dimer interface [polypeptide binding]; other site 1032480003963 catalytic triad [active] 1032480003964 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1032480003965 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1032480003966 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1032480003967 putative active site [active] 1032480003968 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1032480003969 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1032480003970 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1032480003971 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1032480003972 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1032480003973 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1032480003974 putative active site [active] 1032480003975 transaldolase; Provisional; Region: PRK03903 1032480003976 catalytic residue [active] 1032480003977 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1032480003978 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480003979 TPP-binding site [chemical binding]; other site 1032480003980 dimer interface [polypeptide binding]; other site 1032480003981 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480003982 PYR/PP interface [polypeptide binding]; other site 1032480003983 dimer interface [polypeptide binding]; other site 1032480003984 TPP binding site [chemical binding]; other site 1032480003985 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480003986 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1032480003987 UbiA prenyltransferase family; Region: UbiA; pfam01040 1032480003988 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1032480003989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480003990 Coenzyme A binding pocket [chemical binding]; other site 1032480003991 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480003992 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480003993 active site 1032480003994 substrate binding site [chemical binding]; other site 1032480003995 ATP binding site [chemical binding]; other site 1032480003996 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1032480003997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1032480003998 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480003999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480004000 active site 1032480004001 motif I; other site 1032480004002 motif II; other site 1032480004003 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1032480004004 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480004005 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480004006 RHS Repeat; Region: RHS_repeat; cl11982 1032480004007 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1032480004008 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004009 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004010 RHS Repeat; Region: RHS_repeat; cl11982 1032480004011 RHS Repeat; Region: RHS_repeat; cl11982 1032480004012 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004013 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004014 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004015 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1032480004016 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1032480004017 RHS Repeat; Region: RHS_repeat; pfam05593 1032480004018 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480004019 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1032480004020 protein-splicing catalytic site; other site 1032480004021 thioester formation/cholesterol transfer; other site 1032480004022 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1032480004023 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480004024 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480004025 active site 1032480004026 ATP binding site [chemical binding]; other site 1032480004027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480004028 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480004029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004030 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1032480004031 NAD(P) binding site [chemical binding]; other site 1032480004032 active site 1032480004033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480004034 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480004035 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1032480004036 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1032480004037 tetramer interface [polypeptide binding]; other site 1032480004038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480004039 catalytic residue [active] 1032480004040 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1032480004041 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1032480004042 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1032480004043 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480004044 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1032480004045 Walker A/P-loop; other site 1032480004046 ATP binding site [chemical binding]; other site 1032480004047 Q-loop/lid; other site 1032480004048 ABC transporter signature motif; other site 1032480004049 Walker B; other site 1032480004050 D-loop; other site 1032480004051 H-loop/switch region; other site 1032480004052 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1032480004053 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1032480004054 active site 1032480004055 DNA binding site [nucleotide binding] 1032480004056 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1032480004057 DNA binding site [nucleotide binding] 1032480004058 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1032480004059 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1032480004060 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1032480004061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480004062 putative DNA binding site [nucleotide binding]; other site 1032480004063 putative Zn2+ binding site [ion binding]; other site 1032480004064 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1032480004065 FeS assembly protein SufB; Region: sufB; TIGR01980 1032480004066 FeS assembly protein SufD; Region: sufD; TIGR01981 1032480004067 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1032480004068 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1032480004069 [2Fe-2S] cluster binding site [ion binding]; other site 1032480004070 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1032480004071 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1032480004072 Walker A/P-loop; other site 1032480004073 ATP binding site [chemical binding]; other site 1032480004074 Q-loop/lid; other site 1032480004075 ABC transporter signature motif; other site 1032480004076 Walker B; other site 1032480004077 D-loop; other site 1032480004078 H-loop/switch region; other site 1032480004079 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1032480004080 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1032480004081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004082 catalytic residue [active] 1032480004083 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1032480004084 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1032480004085 trimerization site [polypeptide binding]; other site 1032480004086 active site 1032480004087 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1032480004088 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1032480004089 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480004090 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480004091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480004092 active site 1032480004093 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480004094 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480004095 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480004096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480004097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004098 Walker A/P-loop; other site 1032480004099 ATP binding site [chemical binding]; other site 1032480004100 Q-loop/lid; other site 1032480004101 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480004102 ABC transporter signature motif; other site 1032480004103 Walker B; other site 1032480004104 D-loop; other site 1032480004105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480004106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004107 S-adenosylmethionine binding site [chemical binding]; other site 1032480004108 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1032480004109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004110 NAD(P) binding site [chemical binding]; other site 1032480004111 active site 1032480004112 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1032480004113 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1032480004114 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1032480004115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480004116 FeS/SAM binding site; other site 1032480004117 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1032480004118 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1032480004119 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1032480004120 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1032480004121 NAD(P) binding site [chemical binding]; other site 1032480004122 homotetramer interface [polypeptide binding]; other site 1032480004123 homodimer interface [polypeptide binding]; other site 1032480004124 active site 1032480004125 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1032480004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004127 NAD(P) binding site [chemical binding]; other site 1032480004128 active site 1032480004129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480004130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480004131 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 1032480004132 cyanophycin synthetase; Provisional; Region: PRK14016 1032480004133 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480004134 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480004135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480004136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480004137 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1032480004138 proposed catalytic triad [active] 1032480004139 active site nucleophile [active] 1032480004140 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480004141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004142 Walker A/P-loop; other site 1032480004143 ATP binding site [chemical binding]; other site 1032480004144 ABC transporter signature motif; other site 1032480004145 Walker B; other site 1032480004146 D-loop; other site 1032480004147 H-loop/switch region; other site 1032480004148 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1032480004149 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1032480004150 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1032480004151 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1032480004152 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1032480004153 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1032480004154 putative deacylase active site [active] 1032480004155 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480004156 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480004157 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480004158 active site 1032480004159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480004160 active site 1032480004161 ATP binding site [chemical binding]; other site 1032480004162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004163 Coenzyme A binding pocket [chemical binding]; other site 1032480004164 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1032480004165 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1032480004166 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1032480004167 active site 1032480004168 catalytic residues [active] 1032480004169 metal binding site [ion binding]; metal-binding site 1032480004170 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1032480004171 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1032480004172 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480004173 active site 1032480004174 DNA binding site [nucleotide binding] 1032480004175 Int/Topo IB signature motif; other site 1032480004176 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480004177 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480004178 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480004179 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1032480004180 rRNA interaction site [nucleotide binding]; other site 1032480004181 S8 interaction site; other site 1032480004182 putative laminin-1 binding site; other site 1032480004183 elongation factor Ts; Provisional; Region: tsf; PRK09377 1032480004184 UBA/TS-N domain; Region: UBA; pfam00627 1032480004185 Elongation factor TS; Region: EF_TS; pfam00889 1032480004186 Elongation factor TS; Region: EF_TS; pfam00889 1032480004187 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1032480004188 putative nucleotide binding site [chemical binding]; other site 1032480004189 uridine monophosphate binding site [chemical binding]; other site 1032480004190 homohexameric interface [polypeptide binding]; other site 1032480004191 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1032480004192 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1032480004193 hinge region; other site 1032480004194 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1032480004195 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1032480004196 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1032480004197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480004198 FeS/SAM binding site; other site 1032480004199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480004200 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480004201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480004202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480004203 DNA binding site [nucleotide binding] 1032480004204 domain linker motif; other site 1032480004205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480004206 ligand binding site [chemical binding]; other site 1032480004207 dimerization interface [polypeptide binding]; other site 1032480004208 Melibiase; Region: Melibiase; pfam02065 1032480004209 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480004210 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480004211 active site 1032480004212 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1032480004213 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1032480004214 putative N- and C-terminal domain interface [polypeptide binding]; other site 1032480004215 putative active site [active] 1032480004216 MgATP binding site [chemical binding]; other site 1032480004217 catalytic site [active] 1032480004218 metal binding site [ion binding]; metal-binding site 1032480004219 putative carbohydrate binding site [chemical binding]; other site 1032480004220 L-arabinose isomerase; Provisional; Region: PRK02929 1032480004221 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1032480004222 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1032480004223 trimer interface [polypeptide binding]; other site 1032480004224 putative substrate binding site [chemical binding]; other site 1032480004225 putative metal binding site [ion binding]; other site 1032480004226 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1032480004227 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1032480004228 intersubunit interface [polypeptide binding]; other site 1032480004229 active site 1032480004230 Zn2+ binding site [ion binding]; other site 1032480004231 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480004232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480004233 DNA-binding site [nucleotide binding]; DNA binding site 1032480004234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480004235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004236 dimer interface [polypeptide binding]; other site 1032480004237 conserved gate region; other site 1032480004238 putative PBP binding loops; other site 1032480004239 ABC-ATPase subunit interface; other site 1032480004240 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480004241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004242 dimer interface [polypeptide binding]; other site 1032480004243 putative PBP binding loops; other site 1032480004244 ABC-ATPase subunit interface; other site 1032480004245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480004246 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480004247 Melibiase; Region: Melibiase; pfam02065 1032480004248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480004249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480004250 DNA binding site [nucleotide binding] 1032480004251 domain linker motif; other site 1032480004252 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480004253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480004254 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1032480004255 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1032480004256 Cation efflux family; Region: Cation_efflux; pfam01545 1032480004257 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1032480004258 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1032480004259 catalytic motif [active] 1032480004260 Zn binding site [ion binding]; other site 1032480004261 RibD C-terminal domain; Region: RibD_C; cl17279 1032480004262 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1032480004263 Lumazine binding domain; Region: Lum_binding; pfam00677 1032480004264 Lumazine binding domain; Region: Lum_binding; pfam00677 1032480004265 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1032480004266 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1032480004267 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1032480004268 homopentamer interface [polypeptide binding]; other site 1032480004269 active site 1032480004270 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480004271 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480004272 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1032480004273 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1032480004274 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1032480004275 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1032480004276 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1032480004277 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1032480004278 active site 1032480004279 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1032480004280 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1032480004281 putative substrate binding region [chemical binding]; other site 1032480004282 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480004283 putative active site [active] 1032480004284 metal binding site [ion binding]; metal-binding site 1032480004285 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1032480004286 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1032480004287 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 1032480004288 PH domain interface [polypeptide binding]; other site 1032480004289 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1032480004290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480004291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004292 catalytic residue [active] 1032480004293 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1032480004294 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480004295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480004296 active site 1032480004297 ATP binding site [chemical binding]; other site 1032480004298 substrate binding site [chemical binding]; other site 1032480004299 activation loop (A-loop); other site 1032480004300 aminoglycoside resistance protein; Provisional; Region: PRK13746 1032480004301 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480004302 active site 1032480004303 NTP binding site [chemical binding]; other site 1032480004304 metal binding triad [ion binding]; metal-binding site 1032480004305 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1032480004306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480004307 Integrase core domain; Region: rve; pfam00665 1032480004308 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480004309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480004310 Walker A motif; other site 1032480004311 ATP binding site [chemical binding]; other site 1032480004312 Walker B motif; other site 1032480004313 arginine finger; other site 1032480004314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1032480004315 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1032480004316 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480004317 DNA binding residues [nucleotide binding] 1032480004318 dimer interface [polypeptide binding]; other site 1032480004319 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480004320 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480004321 active site 1032480004322 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480004323 active site 1032480004324 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480004325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480004326 substrate binding site [chemical binding]; other site 1032480004327 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480004328 homotrimer interaction site [polypeptide binding]; other site 1032480004329 putative active site [active] 1032480004330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480004331 active site 1032480004332 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480004333 Ligand binding site; other site 1032480004334 Putative Catalytic site; other site 1032480004335 DXD motif; other site 1032480004336 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1032480004337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480004338 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480004339 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1032480004340 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1032480004341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480004342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480004343 homodimer interface [polypeptide binding]; other site 1032480004344 catalytic residue [active] 1032480004345 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1032480004346 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1032480004347 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1032480004348 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1032480004349 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1032480004350 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480004351 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1032480004352 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1032480004353 dimer interface [polypeptide binding]; other site 1032480004354 motif 1; other site 1032480004355 active site 1032480004356 motif 2; other site 1032480004357 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1032480004358 putative deacylase active site [active] 1032480004359 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1032480004360 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1032480004361 anticodon binding site; other site 1032480004362 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1032480004363 hypothetical protein; Provisional; Region: PRK10621 1032480004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004365 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480004366 Walker A/P-loop; other site 1032480004367 ATP binding site [chemical binding]; other site 1032480004368 Q-loop/lid; other site 1032480004369 ABC transporter signature motif; other site 1032480004370 Walker B; other site 1032480004371 D-loop; other site 1032480004372 H-loop/switch region; other site 1032480004373 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480004374 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1032480004375 Walker A/P-loop; other site 1032480004376 ATP binding site [chemical binding]; other site 1032480004377 Q-loop/lid; other site 1032480004378 ABC transporter signature motif; other site 1032480004379 Walker B; other site 1032480004380 D-loop; other site 1032480004381 H-loop/switch region; other site 1032480004382 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1032480004383 Predicted membrane protein [Function unknown]; Region: COG3212 1032480004384 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1032480004385 Sulfatase; Region: Sulfatase; pfam00884 1032480004386 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1032480004387 Sm and related proteins; Region: Sm_like; cl00259 1032480004388 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1032480004389 putative oligomer interface [polypeptide binding]; other site 1032480004390 putative RNA binding site [nucleotide binding]; other site 1032480004391 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1032480004392 NusA N-terminal domain; Region: NusA_N; pfam08529 1032480004393 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1032480004394 RNA binding site [nucleotide binding]; other site 1032480004395 homodimer interface [polypeptide binding]; other site 1032480004396 NusA-like KH domain; Region: KH_5; pfam13184 1032480004397 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1032480004398 G-X-X-G motif; other site 1032480004399 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480004400 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480004401 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480004402 FtsX-like permease family; Region: FtsX; pfam02687 1032480004403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480004404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480004405 Walker A/P-loop; other site 1032480004406 ATP binding site [chemical binding]; other site 1032480004407 Q-loop/lid; other site 1032480004408 ABC transporter signature motif; other site 1032480004409 Walker B; other site 1032480004410 D-loop; other site 1032480004411 H-loop/switch region; other site 1032480004412 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480004413 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1032480004414 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480004415 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1032480004416 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1032480004417 putative RNA binding cleft [nucleotide binding]; other site 1032480004418 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1032480004419 translation initiation factor IF-2; Region: IF-2; TIGR00487 1032480004420 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1032480004421 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1032480004422 G1 box; other site 1032480004423 putative GEF interaction site [polypeptide binding]; other site 1032480004424 GTP/Mg2+ binding site [chemical binding]; other site 1032480004425 Switch I region; other site 1032480004426 G2 box; other site 1032480004427 G3 box; other site 1032480004428 Switch II region; other site 1032480004429 G4 box; other site 1032480004430 G5 box; other site 1032480004431 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1032480004432 Translation-initiation factor 2; Region: IF-2; pfam11987 1032480004433 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1032480004434 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1032480004435 agmatinase; Region: agmatinase; TIGR01230 1032480004436 oligomer interface [polypeptide binding]; other site 1032480004437 putative active site [active] 1032480004438 Mn binding site [ion binding]; other site 1032480004439 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1032480004440 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1032480004441 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1032480004442 RNA binding site [nucleotide binding]; other site 1032480004443 active site 1032480004444 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1032480004445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004446 S-adenosylmethionine binding site [chemical binding]; other site 1032480004447 HTH-like domain; Region: HTH_21; pfam13276 1032480004448 Integrase core domain; Region: rve; pfam00665 1032480004449 Integrase core domain; Region: rve_3; pfam13683 1032480004450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480004451 Transposase; Region: HTH_Tnp_1; pfam01527 1032480004452 AAA ATPase domain; Region: AAA_16; pfam13191 1032480004453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004455 DNA binding residues [nucleotide binding] 1032480004456 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1032480004457 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1032480004458 active site 1032480004459 Riboflavin kinase; Region: Flavokinase; pfam01687 1032480004460 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1032480004461 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480004462 substrate binding site [chemical binding]; other site 1032480004463 ATP binding site [chemical binding]; other site 1032480004464 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1032480004465 16S/18S rRNA binding site [nucleotide binding]; other site 1032480004466 S13e-L30e interaction site [polypeptide binding]; other site 1032480004467 25S rRNA binding site [nucleotide binding]; other site 1032480004468 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1032480004469 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1032480004470 oligomer interface [polypeptide binding]; other site 1032480004471 RNA binding site [nucleotide binding]; other site 1032480004472 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1032480004473 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1032480004474 RNase E interface [polypeptide binding]; other site 1032480004475 trimer interface [polypeptide binding]; other site 1032480004476 active site 1032480004477 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1032480004478 putative nucleic acid binding region [nucleotide binding]; other site 1032480004479 G-X-X-G motif; other site 1032480004480 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1032480004481 RNA binding site [nucleotide binding]; other site 1032480004482 domain interface; other site 1032480004483 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480004484 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1032480004485 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480004486 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1032480004487 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1032480004488 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1032480004489 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1032480004490 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 1032480004491 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480004492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004493 catalytic residue [active] 1032480004494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480004496 active site 1032480004497 phosphorylation site [posttranslational modification] 1032480004498 intermolecular recognition site; other site 1032480004499 dimerization interface [polypeptide binding]; other site 1032480004500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004501 DNA binding residues [nucleotide binding] 1032480004502 dimerization interface [polypeptide binding]; other site 1032480004503 Histidine kinase; Region: HisKA_3; pfam07730 1032480004504 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480004505 ATP binding site [chemical binding]; other site 1032480004506 Mg2+ binding site [ion binding]; other site 1032480004507 G-X-G motif; other site 1032480004508 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480004509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1032480004510 Walker A/P-loop; other site 1032480004511 ATP binding site [chemical binding]; other site 1032480004512 Q-loop/lid; other site 1032480004513 ABC transporter signature motif; other site 1032480004514 Walker B; other site 1032480004515 D-loop; other site 1032480004516 H-loop/switch region; other site 1032480004517 adhesin; Provisional; Region: PRK09752 1032480004518 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480004519 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1032480004520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004522 Coenzyme A binding pocket [chemical binding]; other site 1032480004523 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1032480004524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480004525 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1032480004526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480004527 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1032480004528 AAA domain; Region: AAA_14; pfam13173 1032480004529 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1032480004530 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1032480004531 DAK2 domain; Region: Dak2; cl03685 1032480004532 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1032480004533 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1032480004534 generic binding surface II; other site 1032480004535 ssDNA binding site; other site 1032480004536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480004537 ATP binding site [chemical binding]; other site 1032480004538 putative Mg++ binding site [ion binding]; other site 1032480004539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480004540 nucleotide binding region [chemical binding]; other site 1032480004541 ATP-binding site [chemical binding]; other site 1032480004542 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1032480004543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004544 S-adenosylmethionine binding site [chemical binding]; other site 1032480004545 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1032480004546 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1032480004547 active site 1032480004548 (T/H)XGH motif; other site 1032480004549 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1032480004550 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1032480004551 ribonuclease III; Reviewed; Region: rnc; PRK00102 1032480004552 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1032480004553 dimerization interface [polypeptide binding]; other site 1032480004554 active site 1032480004555 metal binding site [ion binding]; metal-binding site 1032480004556 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1032480004557 dsRNA binding site [nucleotide binding]; other site 1032480004558 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1032480004559 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1032480004560 DNA binding site [nucleotide binding] 1032480004561 catalytic residue [active] 1032480004562 H2TH interface [polypeptide binding]; other site 1032480004563 putative catalytic residues [active] 1032480004564 turnover-facilitating residue; other site 1032480004565 intercalation triad [nucleotide binding]; other site 1032480004566 8OG recognition residue [nucleotide binding]; other site 1032480004567 putative reading head residues; other site 1032480004568 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480004569 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480004570 SnoaL-like domain; Region: SnoaL_2; pfam12680 1032480004571 Predicted transcriptional regulators [Transcription]; Region: COG1733 1032480004572 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1032480004573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480004574 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1032480004575 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1032480004576 Predicted membrane protein [Function unknown]; Region: COG2246 1032480004577 GtrA-like protein; Region: GtrA; pfam04138 1032480004578 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1032480004579 Walker A/P-loop; other site 1032480004580 ATP binding site [chemical binding]; other site 1032480004581 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1032480004582 ABC transporter signature motif; other site 1032480004583 Walker B; other site 1032480004584 D-loop; other site 1032480004585 H-loop/switch region; other site 1032480004586 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1032480004587 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1032480004588 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480004589 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480004590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004591 NAD(P) binding site [chemical binding]; other site 1032480004592 active site 1032480004593 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1032480004594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480004595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480004596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480004598 Coenzyme A binding pocket [chemical binding]; other site 1032480004599 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480004600 Ligand Binding Site [chemical binding]; other site 1032480004601 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480004602 Ligand Binding Site [chemical binding]; other site 1032480004603 putative catalytic site [active] 1032480004604 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480004605 putative metal binding site [ion binding]; other site 1032480004606 putative phosphate binding site [ion binding]; other site 1032480004607 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1032480004608 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1032480004609 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1032480004610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480004611 catalytic residue [active] 1032480004612 Histidine kinase; Region: HisKA_3; pfam07730 1032480004613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480004614 ATP binding site [chemical binding]; other site 1032480004615 Mg2+ binding site [ion binding]; other site 1032480004616 G-X-G motif; other site 1032480004617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480004619 active site 1032480004620 phosphorylation site [posttranslational modification] 1032480004621 intermolecular recognition site; other site 1032480004622 dimerization interface [polypeptide binding]; other site 1032480004623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480004624 DNA binding residues [nucleotide binding] 1032480004625 dimerization interface [polypeptide binding]; other site 1032480004626 signal recognition particle protein; Provisional; Region: PRK10867 1032480004627 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1032480004628 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1032480004629 P loop; other site 1032480004630 GTP binding site [chemical binding]; other site 1032480004631 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1032480004632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480004633 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480004634 Amidohydrolase; Region: Amidohydro_4; pfam13147 1032480004635 active site 1032480004636 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1032480004637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480004638 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1032480004639 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1032480004640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004641 Walker A/P-loop; other site 1032480004642 ATP binding site [chemical binding]; other site 1032480004643 Q-loop/lid; other site 1032480004644 ABC transporter signature motif; other site 1032480004645 Walker B; other site 1032480004646 D-loop; other site 1032480004647 H-loop/switch region; other site 1032480004648 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1032480004649 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1032480004650 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1032480004651 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480004652 active site 1032480004653 Shikimate kinase; Region: SKI; pfam01202 1032480004654 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1032480004655 hypothetical protein; Provisional; Region: PRK02821 1032480004656 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1032480004657 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1032480004658 RimM N-terminal domain; Region: RimM; pfam01782 1032480004659 PRC-barrel domain; Region: PRC; pfam05239 1032480004660 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1032480004661 Putative esterase; Region: Esterase; pfam00756 1032480004662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480004663 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480004664 active site 1032480004665 catalytic triad [active] 1032480004666 oxyanion hole [active] 1032480004667 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1032480004668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480004669 NAD(P) binding site [chemical binding]; other site 1032480004670 active site 1032480004671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004672 S-adenosylmethionine binding site [chemical binding]; other site 1032480004673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004674 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1032480004675 Walker A/P-loop; other site 1032480004676 ATP binding site [chemical binding]; other site 1032480004677 Q-loop/lid; other site 1032480004678 ABC transporter signature motif; other site 1032480004679 Walker B; other site 1032480004680 D-loop; other site 1032480004681 H-loop/switch region; other site 1032480004682 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1032480004683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1032480004684 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1032480004685 DNA binding site [nucleotide binding] 1032480004686 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480004687 AAA domain; Region: AAA_22; pfam13401 1032480004688 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1032480004689 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1032480004690 putative Iron-sulfur protein interface [polypeptide binding]; other site 1032480004691 proximal heme binding site [chemical binding]; other site 1032480004692 distal heme binding site [chemical binding]; other site 1032480004693 putative dimer interface [polypeptide binding]; other site 1032480004694 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1032480004695 L-aspartate oxidase; Provisional; Region: PRK06175 1032480004696 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1032480004697 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1032480004698 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1032480004699 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1032480004700 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480004701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480004702 Walker A/P-loop; other site 1032480004703 ATP binding site [chemical binding]; other site 1032480004704 Q-loop/lid; other site 1032480004705 ABC transporter signature motif; other site 1032480004706 Walker B; other site 1032480004707 D-loop; other site 1032480004708 H-loop/switch region; other site 1032480004709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480004710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480004711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480004712 salt bridge; other site 1032480004713 non-specific DNA binding site [nucleotide binding]; other site 1032480004714 sequence-specific DNA binding site [nucleotide binding]; other site 1032480004715 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1032480004716 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1032480004717 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480004718 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480004719 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1032480004720 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1032480004721 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1032480004722 Catalytic site [active] 1032480004723 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1032480004724 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1032480004725 Catalytic site [active] 1032480004726 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1032480004727 RNA/DNA hybrid binding site [nucleotide binding]; other site 1032480004728 active site 1032480004729 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1032480004730 hypothetical protein; Reviewed; Region: PRK12497 1032480004731 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1032480004732 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1032480004733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480004734 Walker A motif; other site 1032480004735 ATP binding site [chemical binding]; other site 1032480004736 Walker B motif; other site 1032480004737 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1032480004738 DNA protecting protein DprA; Region: dprA; TIGR00732 1032480004739 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1032480004740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480004741 putative DNA binding site [nucleotide binding]; other site 1032480004742 putative Zn2+ binding site [ion binding]; other site 1032480004743 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1032480004744 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480004745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1032480004746 Putative esterase; Region: Esterase; pfam00756 1032480004747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1032480004748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480004749 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1032480004750 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1032480004751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480004752 S-adenosylmethionine binding site [chemical binding]; other site 1032480004753 Dienelactone hydrolase family; Region: DLH; pfam01738 1032480004754 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1032480004755 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1032480004756 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1032480004757 putative active site [active] 1032480004758 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480004760 Y-family of DNA polymerases; Region: PolY; cl12025 1032480004761 active site 1032480004762 DNA binding site [nucleotide binding] 1032480004763 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1032480004764 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1032480004765 active site 1032480004766 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1032480004767 generic binding surface II; other site 1032480004768 generic binding surface I; other site 1032480004769 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1032480004770 active site 1032480004771 TIR domain; Region: TIR_2; pfam13676 1032480004772 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480004773 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1032480004774 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1032480004775 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1032480004776 dimerization interface [polypeptide binding]; other site 1032480004777 DPS ferroxidase diiron center [ion binding]; other site 1032480004778 ion pore; other site 1032480004779 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1032480004780 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1032480004781 NAD(P) binding site [chemical binding]; other site 1032480004782 catalytic residues [active] 1032480004783 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480004784 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480004785 DoxX-like family; Region: DoxX_2; pfam13564 1032480004786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480004787 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480004788 active site 1032480004789 catalytic tetrad [active] 1032480004790 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1032480004791 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1032480004792 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480004793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480004794 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480004795 Putative zinc-finger; Region: zf-HC2; pfam13490 1032480004796 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1032480004797 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1032480004798 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480004799 catalytic core [active] 1032480004800 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1032480004801 conserved hypothetical protein; Region: TIGR03843 1032480004802 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004803 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1032480004804 active site 1032480004805 HIGH motif; other site 1032480004806 nucleotide binding site [chemical binding]; other site 1032480004807 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480004808 active site 1032480004809 KMSKS motif; other site 1032480004810 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1032480004811 tRNA binding surface [nucleotide binding]; other site 1032480004812 anticodon binding site; other site 1032480004813 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1032480004814 metal binding site [ion binding]; metal-binding site 1032480004815 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1032480004816 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1032480004817 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1032480004818 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1032480004819 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1032480004820 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1032480004821 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1032480004822 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1032480004823 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1032480004824 23S rRNA binding site [nucleotide binding]; other site 1032480004825 L21 binding site [polypeptide binding]; other site 1032480004826 L13 binding site [polypeptide binding]; other site 1032480004827 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1032480004828 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1032480004829 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1032480004830 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1032480004831 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1032480004832 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1032480004833 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1032480004834 dimer interface [polypeptide binding]; other site 1032480004835 motif 1; other site 1032480004836 active site 1032480004837 motif 2; other site 1032480004838 motif 3; other site 1032480004839 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1032480004840 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1032480004841 putative tRNA-binding site [nucleotide binding]; other site 1032480004842 B3/4 domain; Region: B3_4; pfam03483 1032480004843 tRNA synthetase B5 domain; Region: B5; smart00874 1032480004844 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1032480004845 dimer interface [polypeptide binding]; other site 1032480004846 motif 1; other site 1032480004847 motif 3; other site 1032480004848 motif 2; other site 1032480004849 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1032480004850 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480004851 AAA domain; Region: AAA_17; pfam13207 1032480004852 AAA domain; Region: AAA_18; pfam13238 1032480004853 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1032480004854 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1032480004855 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1032480004856 Family description; Region: ACT_7; pfam13840 1032480004857 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1032480004858 heterotetramer interface [polypeptide binding]; other site 1032480004859 active site pocket [active] 1032480004860 cleavage site 1032480004861 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1032480004862 feedback inhibition sensing region; other site 1032480004863 homohexameric interface [polypeptide binding]; other site 1032480004864 nucleotide binding site [chemical binding]; other site 1032480004865 N-acetyl-L-glutamate binding site [chemical binding]; other site 1032480004866 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1032480004867 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480004868 inhibitor-cofactor binding pocket; inhibition site 1032480004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480004870 catalytic residue [active] 1032480004871 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1032480004872 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1032480004873 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1032480004874 arginine repressor; Provisional; Region: PRK03341 1032480004875 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1032480004876 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1032480004877 argininosuccinate lyase; Provisional; Region: PRK00855 1032480004878 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1032480004879 active sites [active] 1032480004880 tetramer interface [polypeptide binding]; other site 1032480004881 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1032480004882 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1032480004883 active site 1032480004884 HIGH motif; other site 1032480004885 dimer interface [polypeptide binding]; other site 1032480004886 KMSKS motif; other site 1032480004887 potential protein location (hypothetical protein MLP_17290 [Microlunatus phosphovorus NM-1]) that overlaps RNA (23S ribosomal RNA) 1032480004888 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480004889 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1032480004890 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480004891 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480004892 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1032480004893 putative NAD(P) binding site [chemical binding]; other site 1032480004894 catalytic Zn binding site [ion binding]; other site 1032480004895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480004896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004897 dimer interface [polypeptide binding]; other site 1032480004898 conserved gate region; other site 1032480004899 putative PBP binding loops; other site 1032480004900 ABC-ATPase subunit interface; other site 1032480004901 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1032480004902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480004903 dimer interface [polypeptide binding]; other site 1032480004904 putative PBP binding loops; other site 1032480004905 ABC-ATPase subunit interface; other site 1032480004906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480004907 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480004908 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480004909 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480004910 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1032480004911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480004912 active site 1032480004913 motif I; other site 1032480004914 motif II; other site 1032480004915 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1032480004916 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480004917 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1032480004918 active site 1032480004919 catalytic site [active] 1032480004920 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480004921 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1032480004922 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480004923 RNA binding surface [nucleotide binding]; other site 1032480004924 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1032480004925 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1032480004926 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1032480004927 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1032480004928 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1032480004929 Walker A/P-loop; other site 1032480004930 ATP binding site [chemical binding]; other site 1032480004931 Q-loop/lid; other site 1032480004932 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1032480004933 ABC transporter signature motif; other site 1032480004934 Walker B; other site 1032480004935 D-loop; other site 1032480004936 H-loop/switch region; other site 1032480004937 transcription termination factor Rho; Provisional; Region: PRK12678 1032480004938 CTP synthetase; Validated; Region: pyrG; PRK05380 1032480004939 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1032480004940 Catalytic site [active] 1032480004941 active site 1032480004942 UTP binding site [chemical binding]; other site 1032480004943 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1032480004944 active site 1032480004945 putative oxyanion hole; other site 1032480004946 catalytic triad [active] 1032480004947 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1032480004948 dimer interface [polypeptide binding]; other site 1032480004949 ADP-ribose binding site [chemical binding]; other site 1032480004950 active site 1032480004951 nudix motif; other site 1032480004952 metal binding site [ion binding]; metal-binding site 1032480004953 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1032480004954 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1032480004955 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1032480004956 hexamer interface [polypeptide binding]; other site 1032480004957 ligand binding site [chemical binding]; other site 1032480004958 putative active site [active] 1032480004959 NAD(P) binding site [chemical binding]; other site 1032480004960 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1032480004961 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480004962 active site 1032480004963 DNA binding site [nucleotide binding] 1032480004964 Int/Topo IB signature motif; other site 1032480004965 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480004966 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480004967 P-loop; other site 1032480004968 Magnesium ion binding site [ion binding]; other site 1032480004969 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480004970 Magnesium ion binding site [ion binding]; other site 1032480004971 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1032480004972 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1032480004973 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1032480004974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480004975 RNA binding surface [nucleotide binding]; other site 1032480004976 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1032480004977 active site 1032480004978 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1032480004979 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1032480004980 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1032480004981 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1032480004982 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1032480004983 active site 1032480004984 HIGH motif; other site 1032480004985 nucleotide binding site [chemical binding]; other site 1032480004986 active site 1032480004987 KMSKS motif; other site 1032480004988 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480004989 WYL domain; Region: WYL; pfam13280 1032480004990 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480004991 WYL domain; Region: WYL; pfam13280 1032480004992 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1032480004993 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1032480004994 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1032480004995 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1032480004996 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480004997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480004998 ATP binding site [chemical binding]; other site 1032480004999 putative Mg++ binding site [ion binding]; other site 1032480005000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005001 nucleotide binding region [chemical binding]; other site 1032480005002 ATP-binding site [chemical binding]; other site 1032480005003 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1032480005004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005005 S-adenosylmethionine binding site [chemical binding]; other site 1032480005006 TPR repeat; Region: TPR_11; pfam13414 1032480005007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005009 DNA binding residues [nucleotide binding] 1032480005010 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1032480005011 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1032480005012 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480005013 tetramer interface [polypeptide binding]; other site 1032480005014 active site 1032480005015 Mg2+/Mn2+ binding site [ion binding]; other site 1032480005016 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1032480005017 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1032480005018 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480005019 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1032480005020 DNA binding residues [nucleotide binding] 1032480005021 B12 binding domain; Region: B12-binding_2; pfam02607 1032480005022 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480005023 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1032480005024 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1032480005025 active site 1032480005026 metal binding site [ion binding]; metal-binding site 1032480005027 nudix motif; other site 1032480005028 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1032480005029 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480005030 substrate binding pocket [chemical binding]; other site 1032480005031 chain length determination region; other site 1032480005032 substrate-Mg2+ binding site; other site 1032480005033 catalytic residues [active] 1032480005034 aspartate-rich region 1; other site 1032480005035 active site lid residues [active] 1032480005036 aspartate-rich region 2; other site 1032480005037 phytoene desaturase; Region: crtI_fam; TIGR02734 1032480005038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480005039 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1032480005040 active site lid residues [active] 1032480005041 substrate binding pocket [chemical binding]; other site 1032480005042 catalytic residues [active] 1032480005043 substrate-Mg2+ binding site; other site 1032480005044 aspartate-rich region 1; other site 1032480005045 aspartate-rich region 2; other site 1032480005046 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480005047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480005049 Transposase; Region: HTH_Tnp_1; cl17663 1032480005050 putative transposase OrfB; Reviewed; Region: PHA02517 1032480005051 HTH-like domain; Region: HTH_21; pfam13276 1032480005052 Integrase core domain; Region: rve; pfam00665 1032480005053 Integrase core domain; Region: rve_3; pfam13683 1032480005054 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1032480005055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480005056 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480005057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005058 S-adenosylmethionine binding site [chemical binding]; other site 1032480005059 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1032480005060 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1032480005061 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1032480005062 Cytochrome P450; Region: p450; cl12078 1032480005063 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1032480005064 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1032480005065 substrate binding site [chemical binding]; other site 1032480005066 glutamase interaction surface [polypeptide binding]; other site 1032480005067 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1032480005068 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1032480005069 putative ligand binding site [chemical binding]; other site 1032480005070 putative NAD binding site [chemical binding]; other site 1032480005071 catalytic site [active] 1032480005072 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1032480005073 HIT family signature motif; other site 1032480005074 catalytic residue [active] 1032480005075 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1032480005076 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1032480005077 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480005078 PLD-like domain; Region: PLDc_2; pfam13091 1032480005079 putative active site [active] 1032480005080 catalytic site [active] 1032480005081 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480005082 PLD-like domain; Region: PLDc_2; pfam13091 1032480005083 putative active site [active] 1032480005084 catalytic site [active] 1032480005085 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480005086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480005087 active site 1032480005088 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1032480005089 putative dimer interface [polypeptide binding]; other site 1032480005090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480005091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480005092 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480005093 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1032480005094 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1032480005095 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1032480005096 putative active site [active] 1032480005097 putative metal binding site [ion binding]; other site 1032480005098 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1032480005099 metal binding site [ion binding]; metal-binding site 1032480005100 Peptidase family M28; Region: Peptidase_M28; pfam04389 1032480005101 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1032480005102 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480005103 PYR/PP interface [polypeptide binding]; other site 1032480005104 dimer interface [polypeptide binding]; other site 1032480005105 TPP binding site [chemical binding]; other site 1032480005106 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480005107 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1032480005108 TPP-binding site [chemical binding]; other site 1032480005109 dimer interface [polypeptide binding]; other site 1032480005110 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1032480005111 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1032480005112 putative valine binding site [chemical binding]; other site 1032480005113 dimer interface [polypeptide binding]; other site 1032480005114 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1032480005115 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1032480005116 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1032480005117 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1032480005118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005119 S-adenosylmethionine binding site [chemical binding]; other site 1032480005120 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1032480005121 tartrate dehydrogenase; Region: TTC; TIGR02089 1032480005122 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1032480005123 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1032480005124 homodimer interface [polypeptide binding]; other site 1032480005125 substrate-cofactor binding pocket; other site 1032480005126 catalytic residue [active] 1032480005127 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1032480005128 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1032480005129 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1032480005130 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1032480005131 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480005132 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1032480005133 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1032480005134 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480005135 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1032480005136 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1032480005137 NAD binding site [chemical binding]; other site 1032480005138 dimerization interface [polypeptide binding]; other site 1032480005139 product binding site; other site 1032480005140 substrate binding site [chemical binding]; other site 1032480005141 zinc binding site [ion binding]; other site 1032480005142 catalytic residues [active] 1032480005143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480005144 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1032480005145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480005146 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1032480005147 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480005148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480005149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480005150 Walker A/P-loop; other site 1032480005151 ATP binding site [chemical binding]; other site 1032480005152 Q-loop/lid; other site 1032480005153 ABC transporter signature motif; other site 1032480005154 Walker B; other site 1032480005155 D-loop; other site 1032480005156 H-loop/switch region; other site 1032480005157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480005158 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480005159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480005160 Walker A/P-loop; other site 1032480005161 ATP binding site [chemical binding]; other site 1032480005162 Q-loop/lid; other site 1032480005163 ABC transporter signature motif; other site 1032480005164 Walker B; other site 1032480005165 D-loop; other site 1032480005166 H-loop/switch region; other site 1032480005167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005168 S-adenosylmethionine binding site [chemical binding]; other site 1032480005169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480005170 dimerization interface [polypeptide binding]; other site 1032480005171 putative DNA binding site [nucleotide binding]; other site 1032480005172 putative Zn2+ binding site [ion binding]; other site 1032480005173 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480005174 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1032480005175 Walker A/P-loop; other site 1032480005176 ATP binding site [chemical binding]; other site 1032480005177 Q-loop/lid; other site 1032480005178 ABC transporter signature motif; other site 1032480005179 Walker B; other site 1032480005180 D-loop; other site 1032480005181 H-loop/switch region; other site 1032480005182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005183 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1032480005184 Walker A/P-loop; other site 1032480005185 ATP binding site [chemical binding]; other site 1032480005186 Q-loop/lid; other site 1032480005187 ABC transporter signature motif; other site 1032480005188 Walker B; other site 1032480005189 D-loop; other site 1032480005190 H-loop/switch region; other site 1032480005191 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1032480005192 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1032480005193 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1032480005194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480005195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005196 Walker A/P-loop; other site 1032480005197 ATP binding site [chemical binding]; other site 1032480005198 Q-loop/lid; other site 1032480005199 ABC transporter signature motif; other site 1032480005200 Walker B; other site 1032480005201 D-loop; other site 1032480005202 H-loop/switch region; other site 1032480005203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480005204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005205 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480005206 Walker A/P-loop; other site 1032480005207 ATP binding site [chemical binding]; other site 1032480005208 Q-loop/lid; other site 1032480005209 ABC transporter signature motif; other site 1032480005210 Walker B; other site 1032480005211 D-loop; other site 1032480005212 H-loop/switch region; other site 1032480005213 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1032480005214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480005215 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1032480005216 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1032480005217 active site 1032480005218 catalytic residues [active] 1032480005219 metal binding site [ion binding]; metal-binding site 1032480005220 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1032480005221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480005222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480005223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005224 Walker A/P-loop; other site 1032480005225 ATP binding site [chemical binding]; other site 1032480005226 Q-loop/lid; other site 1032480005227 ABC transporter signature motif; other site 1032480005228 Walker B; other site 1032480005229 D-loop; other site 1032480005230 H-loop/switch region; other site 1032480005231 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1032480005232 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1032480005233 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1032480005234 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1032480005235 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1032480005236 HIGH motif; other site 1032480005237 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1032480005238 active site 1032480005239 KMSKS motif; other site 1032480005240 CAAX protease self-immunity; Region: Abi; pfam02517 1032480005241 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480005242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005243 DNA-binding site [nucleotide binding]; DNA binding site 1032480005244 FCD domain; Region: FCD; pfam07729 1032480005245 ethanolamine permease; Region: 2A0305; TIGR00908 1032480005246 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1032480005247 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480005248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480005249 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480005250 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005251 NAD(P) binding site [chemical binding]; other site 1032480005252 catalytic residues [active] 1032480005253 short chain dehydrogenase; Provisional; Region: PRK06057 1032480005254 classical (c) SDRs; Region: SDR_c; cd05233 1032480005255 NAD(P) binding site [chemical binding]; other site 1032480005256 active site 1032480005257 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1032480005258 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1032480005259 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1032480005260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005261 Walker A/P-loop; other site 1032480005262 ATP binding site [chemical binding]; other site 1032480005263 Q-loop/lid; other site 1032480005264 ABC transporter signature motif; other site 1032480005265 Walker B; other site 1032480005266 D-loop; other site 1032480005267 H-loop/switch region; other site 1032480005268 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1032480005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005270 dimer interface [polypeptide binding]; other site 1032480005271 conserved gate region; other site 1032480005272 putative PBP binding loops; other site 1032480005273 ABC-ATPase subunit interface; other site 1032480005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005275 dimer interface [polypeptide binding]; other site 1032480005276 conserved gate region; other site 1032480005277 ABC-ATPase subunit interface; other site 1032480005278 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1032480005279 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480005280 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480005281 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480005282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480005283 motif II; other site 1032480005284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480005285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1032480005286 DNA-binding site [nucleotide binding]; DNA binding site 1032480005287 UTRA domain; Region: UTRA; pfam07702 1032480005288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480005289 active site 1032480005290 DNA binding site [nucleotide binding] 1032480005291 Int/Topo IB signature motif; other site 1032480005292 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480005293 short chain dehydrogenase; Validated; Region: PRK08324 1032480005294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480005295 Transposase; Region: HTH_Tnp_1; pfam01527 1032480005296 HTH-like domain; Region: HTH_21; pfam13276 1032480005297 Integrase core domain; Region: rve; pfam00665 1032480005298 Integrase core domain; Region: rve_3; pfam13683 1032480005299 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1032480005300 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 1032480005301 metal binding triad [ion binding]; metal-binding site 1032480005302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480005303 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480005304 nucleotide binding site/active site [active] 1032480005305 HIT family signature motif; other site 1032480005306 catalytic residue [active] 1032480005307 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1032480005308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1032480005309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480005310 active site 1032480005311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480005312 hypothetical protein; Provisional; Region: PRK06762 1032480005313 AAA domain; Region: AAA_33; pfam13671 1032480005314 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1032480005315 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480005316 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005317 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1032480005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480005319 potential frameshift: common BLAST hit: gi|111025755|ref|YP_708175.1| TnpB family transposase 1032480005320 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1032480005321 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1032480005322 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480005323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005324 Helix-turn-helix domain; Region: HTH_28; pfam13518 1032480005325 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480005326 Homeodomain-like domain; Region: HTH_32; pfam13565 1032480005327 Integrase core domain; Region: rve; pfam00665 1032480005328 Integrase core domain; Region: rve_3; cl15866 1032480005329 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1032480005330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480005331 Transposase; Region: HTH_Tnp_1; cl17663 1032480005332 putative transposase OrfB; Reviewed; Region: PHA02517 1032480005333 HTH-like domain; Region: HTH_21; pfam13276 1032480005334 Integrase core domain; Region: rve; pfam00665 1032480005335 Integrase core domain; Region: rve_3; pfam13683 1032480005336 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1032480005337 AAA ATPase domain; Region: AAA_16; pfam13191 1032480005338 Walker A motif; other site 1032480005339 ATP binding site [chemical binding]; other site 1032480005340 Walker B motif; other site 1032480005341 arginine finger; other site 1032480005342 putative transposase OrfB; Reviewed; Region: PHA02517 1032480005343 HTH-like domain; Region: HTH_21; pfam13276 1032480005344 Integrase core domain; Region: rve; pfam00665 1032480005345 Integrase core domain; Region: rve_3; pfam13683 1032480005346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480005347 Transposase; Region: HTH_Tnp_1; cl17663 1032480005348 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1032480005349 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1032480005350 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480005351 putative active site [active] 1032480005352 putative NTP binding site [chemical binding]; other site 1032480005353 putative nucleic acid binding site [nucleotide binding]; other site 1032480005354 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1032480005355 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480005356 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1032480005357 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1032480005358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480005359 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1032480005360 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480005361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480005362 AAA ATPase domain; Region: AAA_16; pfam13191 1032480005363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005365 DNA binding residues [nucleotide binding] 1032480005366 dimerization interface [polypeptide binding]; other site 1032480005367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005369 DNA binding residues [nucleotide binding] 1032480005370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005371 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480005372 hydrophobic ligand binding site; other site 1032480005373 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1032480005374 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1032480005375 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1032480005376 SnoaL-like domain; Region: SnoaL_4; pfam13577 1032480005377 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1032480005378 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480005379 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480005380 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480005381 Berberine and berberine like; Region: BBE; pfam08031 1032480005382 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480005383 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005385 DNA binding residues [nucleotide binding] 1032480005386 dimerization interface [polypeptide binding]; other site 1032480005387 choline dehydrogenase; Validated; Region: PRK02106 1032480005388 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480005389 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1032480005390 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480005391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1032480005392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1032480005393 putative dimer interface [polypeptide binding]; other site 1032480005394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480005395 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1032480005396 active site 1032480005397 8-oxo-dGMP binding site [chemical binding]; other site 1032480005398 nudix motif; other site 1032480005399 metal binding site [ion binding]; metal-binding site 1032480005400 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480005401 PLD-like domain; Region: PLDc_2; pfam13091 1032480005402 putative active site [active] 1032480005403 catalytic site [active] 1032480005404 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480005405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480005406 ATP binding site [chemical binding]; other site 1032480005407 putative Mg++ binding site [ion binding]; other site 1032480005408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005409 nucleotide binding region [chemical binding]; other site 1032480005410 ATP-binding site [chemical binding]; other site 1032480005411 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1032480005412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480005413 AAA domain; Region: AAA_23; pfam13476 1032480005414 Walker A/P-loop; other site 1032480005415 ATP binding site [chemical binding]; other site 1032480005416 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 1032480005417 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1032480005418 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480005419 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480005420 Berberine and berberine like; Region: BBE; pfam08031 1032480005421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005423 DNA binding residues [nucleotide binding] 1032480005424 dimerization interface [polypeptide binding]; other site 1032480005425 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1032480005426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005427 non-specific DNA binding site [nucleotide binding]; other site 1032480005428 salt bridge; other site 1032480005429 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005430 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480005431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480005432 DNA binding residues [nucleotide binding] 1032480005433 YCII-related domain; Region: YCII; cl00999 1032480005434 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480005435 active site 1032480005436 metal binding site [ion binding]; metal-binding site 1032480005437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480005438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005439 S-adenosylmethionine binding site [chemical binding]; other site 1032480005440 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480005441 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1032480005442 Ca binding site [ion binding]; other site 1032480005443 active site 1032480005444 catalytic site [active] 1032480005445 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480005446 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1032480005447 Cupin domain; Region: Cupin_2; pfam07883 1032480005448 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480005449 MarR family; Region: MarR_2; pfam12802 1032480005450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480005451 Coenzyme A binding pocket [chemical binding]; other site 1032480005452 DinI-like family; Region: DinI; cl11630 1032480005453 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1032480005454 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1032480005455 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1032480005456 putative di-iron ligands [ion binding]; other site 1032480005457 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1032480005458 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1032480005459 FAD binding pocket [chemical binding]; other site 1032480005460 FAD binding motif [chemical binding]; other site 1032480005461 phosphate binding motif [ion binding]; other site 1032480005462 beta-alpha-beta structure motif; other site 1032480005463 NAD binding pocket [chemical binding]; other site 1032480005464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1032480005465 catalytic loop [active] 1032480005466 iron binding site [ion binding]; other site 1032480005467 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480005468 TIGR03085 family protein; Region: TIGR03085 1032480005469 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480005470 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1032480005471 active site 1032480005472 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1032480005473 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480005474 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1032480005475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005477 DNA binding residues [nucleotide binding] 1032480005478 dimerization interface [polypeptide binding]; other site 1032480005479 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480005480 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1032480005481 AMP binding site [chemical binding]; other site 1032480005482 metal binding site [ion binding]; metal-binding site 1032480005483 active site 1032480005484 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1032480005485 active site 1032480005486 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 1032480005487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1032480005488 motif I; other site 1032480005489 active site 1032480005490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480005491 motif II; other site 1032480005492 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1032480005493 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1032480005494 substrate binding site [chemical binding]; other site 1032480005495 hexamer interface [polypeptide binding]; other site 1032480005496 metal binding site [ion binding]; metal-binding site 1032480005497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480005499 active site 1032480005500 phosphorylation site [posttranslational modification] 1032480005501 intermolecular recognition site; other site 1032480005502 dimerization interface [polypeptide binding]; other site 1032480005503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005504 DNA binding residues [nucleotide binding] 1032480005505 dimerization interface [polypeptide binding]; other site 1032480005506 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1032480005507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480005508 Histidine kinase; Region: HisKA_3; pfam07730 1032480005509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480005510 ATP binding site [chemical binding]; other site 1032480005511 Mg2+ binding site [ion binding]; other site 1032480005512 G-X-G motif; other site 1032480005513 Class I aldolases; Region: Aldolase_Class_I; cl17187 1032480005514 catalytic residue [active] 1032480005515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480005516 dimerization interface [polypeptide binding]; other site 1032480005517 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1032480005518 multimerization interface [polypeptide binding]; other site 1032480005519 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1032480005520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480005521 Walker A motif; other site 1032480005522 ATP binding site [chemical binding]; other site 1032480005523 Walker B motif; other site 1032480005524 arginine finger; other site 1032480005525 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1032480005526 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1032480005527 putative molybdopterin cofactor binding site [chemical binding]; other site 1032480005528 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1032480005529 putative molybdopterin cofactor binding site; other site 1032480005530 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1032480005531 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1032480005532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480005533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480005534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1032480005535 dimerization interface [polypeptide binding]; other site 1032480005536 formate dehydrogenase; Provisional; Region: PRK07574 1032480005537 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1032480005538 dimerization interface [polypeptide binding]; other site 1032480005539 ligand binding site [chemical binding]; other site 1032480005540 NAD binding site [chemical binding]; other site 1032480005541 catalytic site [active] 1032480005542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480005543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005544 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005545 salt bridge; other site 1032480005546 Cupin domain; Region: Cupin_2; pfam07883 1032480005547 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1032480005548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480005549 S-adenosylmethionine binding site [chemical binding]; other site 1032480005550 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1032480005551 IHF dimer interface [polypeptide binding]; other site 1032480005552 IHF - DNA interface [nucleotide binding]; other site 1032480005553 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480005554 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1032480005555 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1032480005556 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1032480005557 dimer interface [polypeptide binding]; other site 1032480005558 NADP binding site [chemical binding]; other site 1032480005559 catalytic residues [active] 1032480005560 Integrase core domain; Region: rve; pfam00665 1032480005561 Integrase core domain; Region: rve_3; pfam13683 1032480005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005563 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005564 putative substrate translocation pore; other site 1032480005565 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480005566 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480005567 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480005568 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1032480005569 potential frameshift: common BLAST hit: gi|111020279|ref|YP_703251.1| aspartate aminotransferase 1032480005570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480005571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480005572 homodimer interface [polypeptide binding]; other site 1032480005573 catalytic residue [active] 1032480005574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480005575 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1032480005576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005577 NAD(P) binding site [chemical binding]; other site 1032480005578 active site 1032480005579 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1032480005580 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1032480005581 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1032480005582 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1032480005583 putative active site [active] 1032480005584 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480005585 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1032480005586 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1032480005587 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1032480005588 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480005589 carboxyltransferase (CT) interaction site; other site 1032480005590 biotinylation site [posttranslational modification]; other site 1032480005591 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1032480005592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480005593 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1032480005594 putative dimerization interface [polypeptide binding]; other site 1032480005595 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1032480005596 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1032480005597 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1032480005598 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1032480005599 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480005600 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1032480005601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480005602 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1032480005603 Histidine kinase; Region: HisKA_3; pfam07730 1032480005604 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005605 Ligand Binding Site [chemical binding]; other site 1032480005606 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005607 Ligand Binding Site [chemical binding]; other site 1032480005608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480005609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480005610 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1032480005611 putative dimerization interface [polypeptide binding]; other site 1032480005612 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1032480005613 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1032480005614 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1032480005615 choline dehydrogenase; Validated; Region: PRK02106 1032480005616 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480005617 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480005618 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480005619 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480005620 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480005621 inhibitor site; inhibition site 1032480005622 active site 1032480005623 dimer interface [polypeptide binding]; other site 1032480005624 catalytic residue [active] 1032480005625 GAF domain; Region: GAF; cl17456 1032480005626 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005627 NAD(P) binding site [chemical binding]; other site 1032480005628 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005629 catalytic residues [active] 1032480005630 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1032480005631 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480005632 NADP binding site [chemical binding]; other site 1032480005633 dimer interface [polypeptide binding]; other site 1032480005634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480005635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480005636 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480005637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480005638 putative DNA binding site [nucleotide binding]; other site 1032480005639 putative Zn2+ binding site [ion binding]; other site 1032480005640 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480005641 AzlC protein; Region: AzlC; cl00570 1032480005642 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1032480005643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005644 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005645 putative substrate translocation pore; other site 1032480005646 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1032480005647 Part of AAA domain; Region: AAA_19; pfam13245 1032480005648 Family description; Region: UvrD_C_2; pfam13538 1032480005649 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480005650 Ligand Binding Site [chemical binding]; other site 1032480005651 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1032480005652 putative active cleft [active] 1032480005653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480005654 Coenzyme A binding pocket [chemical binding]; other site 1032480005655 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1032480005656 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1032480005657 RES domain; Region: RES; pfam08808 1032480005658 Ribosomal protein L20; Region: Ribosomal_L20; cl00393 1032480005659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480005660 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1032480005661 inhibitor binding site; inhibition site 1032480005662 catalytic Zn binding site [ion binding]; other site 1032480005663 structural Zn binding site [ion binding]; other site 1032480005664 NADP binding site [chemical binding]; other site 1032480005665 tetramer interface [polypeptide binding]; other site 1032480005666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005667 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480005668 putative substrate translocation pore; other site 1032480005669 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1032480005670 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1032480005671 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 1032480005672 active site 1032480005673 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005674 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1032480005675 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005676 Tubby C 2; Region: Tub_2; cl02043 1032480005677 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1032480005678 RNA/DNA hybrid binding site [nucleotide binding]; other site 1032480005679 active site 1032480005680 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480005681 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1032480005682 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1032480005683 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1032480005684 active site 1032480005685 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1032480005686 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1032480005687 [2Fe-2S] cluster binding site [ion binding]; other site 1032480005688 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1032480005689 putative alpha subunit interface [polypeptide binding]; other site 1032480005690 putative active site [active] 1032480005691 putative substrate binding site [chemical binding]; other site 1032480005692 Fe binding site [ion binding]; other site 1032480005693 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1032480005694 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005695 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005696 citrate synthase; Provisional; Region: PRK14033 1032480005697 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1032480005698 oxalacetate binding site [chemical binding]; other site 1032480005699 citrylCoA binding site [chemical binding]; other site 1032480005700 coenzyme A binding site [chemical binding]; other site 1032480005701 catalytic triad [active] 1032480005702 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1032480005703 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480005704 tetramer interface [polypeptide binding]; other site 1032480005705 active site 1032480005706 Mg2+/Mn2+ binding site [ion binding]; other site 1032480005707 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1032480005708 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480005709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005710 DNA-binding site [nucleotide binding]; DNA binding site 1032480005711 FCD domain; Region: FCD; pfam07729 1032480005712 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1032480005713 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480005714 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1032480005715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005716 dimer interface [polypeptide binding]; other site 1032480005717 conserved gate region; other site 1032480005718 putative PBP binding loops; other site 1032480005719 ABC-ATPase subunit interface; other site 1032480005720 sulfate transport protein; Provisional; Region: cysT; CHL00187 1032480005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005722 dimer interface [polypeptide binding]; other site 1032480005723 conserved gate region; other site 1032480005724 putative PBP binding loops; other site 1032480005725 ABC-ATPase subunit interface; other site 1032480005726 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1032480005727 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1032480005728 Walker A/P-loop; other site 1032480005729 ATP binding site [chemical binding]; other site 1032480005730 Q-loop/lid; other site 1032480005731 ABC transporter signature motif; other site 1032480005732 Walker B; other site 1032480005733 D-loop; other site 1032480005734 H-loop/switch region; other site 1032480005735 PRC-barrel domain; Region: PRC; pfam05239 1032480005736 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1032480005737 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480005738 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1032480005739 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480005740 Ligand Binding Site [chemical binding]; other site 1032480005741 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480005742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480005744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480005745 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480005746 substrate binding pocket [chemical binding]; other site 1032480005747 membrane-bound complex binding site; other site 1032480005748 hinge residues; other site 1032480005749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1032480005750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005751 dimer interface [polypeptide binding]; other site 1032480005752 conserved gate region; other site 1032480005753 putative PBP binding loops; other site 1032480005754 ABC-ATPase subunit interface; other site 1032480005755 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480005756 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1032480005757 Walker A/P-loop; other site 1032480005758 ATP binding site [chemical binding]; other site 1032480005759 Q-loop/lid; other site 1032480005760 ABC transporter signature motif; other site 1032480005761 Walker B; other site 1032480005762 D-loop; other site 1032480005763 H-loop/switch region; other site 1032480005764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480005765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480005766 DNA binding residues [nucleotide binding] 1032480005767 short chain dehydrogenase; Provisional; Region: PRK06701 1032480005768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005769 NAD(P) binding site [chemical binding]; other site 1032480005770 active site 1032480005771 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480005772 GAF domain; Region: GAF; pfam01590 1032480005773 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1032480005774 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1032480005775 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1032480005776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480005777 ChaB; Region: ChaB; pfam06150 1032480005778 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480005779 putative catalytic site [active] 1032480005780 putative metal binding site [ion binding]; other site 1032480005781 putative phosphate binding site [ion binding]; other site 1032480005782 BCCT family transporter; Region: BCCT; cl00569 1032480005783 choline dehydrogenase; Validated; Region: PRK02106 1032480005784 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480005785 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480005786 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480005787 NAD(P) binding site [chemical binding]; other site 1032480005788 catalytic residues [active] 1032480005789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005790 DNA-binding site [nucleotide binding]; DNA binding site 1032480005791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480005792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480005793 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480005794 active site 1032480005795 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480005796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480005797 DNA-binding site [nucleotide binding]; DNA binding site 1032480005798 FCD domain; Region: FCD; pfam07729 1032480005799 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1032480005800 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1032480005801 dimer interface [polypeptide binding]; other site 1032480005802 active site 1032480005803 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1032480005804 folate binding site [chemical binding]; other site 1032480005805 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1032480005806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480005807 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480005808 sarcosine oxidase, delta subunit family, heterotetrameric form; Region: soxD; TIGR01374 1032480005809 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1032480005810 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1032480005811 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480005812 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 1032480005813 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1032480005814 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1032480005815 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1032480005816 Predicted membrane protein [Function unknown]; Region: COG4325 1032480005817 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1032480005818 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1032480005819 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1032480005820 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1032480005821 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480005822 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480005823 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1032480005824 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1032480005825 substrate binding site [chemical binding]; other site 1032480005826 ligand binding site [chemical binding]; other site 1032480005827 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1032480005828 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1032480005829 substrate binding site [chemical binding]; other site 1032480005830 putative transposase OrfB; Reviewed; Region: PHA02517 1032480005831 Integrase core domain; Region: rve; pfam00665 1032480005832 Integrase core domain; Region: rve_3; pfam13683 1032480005833 cell division protein GpsB; Provisional; Region: PRK14127 1032480005834 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1032480005835 IHF - DNA interface [nucleotide binding]; other site 1032480005836 IHF dimer interface [polypeptide binding]; other site 1032480005837 Guanylyl transferase CofC like; Region: CofC; cl17472 1032480005838 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480005839 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480005840 putative acyl-acceptor binding pocket; other site 1032480005841 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1032480005842 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1032480005843 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1032480005844 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480005845 DinB superfamily; Region: DinB_2; pfam12867 1032480005846 YCII-related domain; Region: YCII; cl00999 1032480005847 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1032480005848 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1032480005849 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1032480005850 Cytochrome P450; Region: p450; cl12078 1032480005851 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1032480005852 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1032480005853 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480005854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480005855 catalytic residue [active] 1032480005856 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1032480005857 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1032480005858 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480005859 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480005860 active site 1032480005861 metal binding site [ion binding]; metal-binding site 1032480005862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480005863 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1032480005864 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480005865 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480005866 thiamine monophosphate kinase; Provisional; Region: PRK05731 1032480005867 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1032480005868 ATP binding site [chemical binding]; other site 1032480005869 dimerization interface [polypeptide binding]; other site 1032480005870 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1032480005871 dimer interface [polypeptide binding]; other site 1032480005872 substrate binding site [chemical binding]; other site 1032480005873 ATP binding site [chemical binding]; other site 1032480005874 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1032480005875 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1032480005876 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1032480005877 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1032480005878 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1032480005879 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1032480005880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480005881 FeS/SAM binding site; other site 1032480005882 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1032480005883 Competence-damaged protein; Region: CinA; pfam02464 1032480005884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480005885 non-specific DNA binding site [nucleotide binding]; other site 1032480005886 salt bridge; other site 1032480005887 sequence-specific DNA binding site [nucleotide binding]; other site 1032480005888 AAA ATPase domain; Region: AAA_16; pfam13191 1032480005889 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1032480005890 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480005892 DNA binding residues [nucleotide binding] 1032480005893 dimerization interface [polypeptide binding]; other site 1032480005894 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480005895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480005896 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1032480005897 ATP binding site [chemical binding]; other site 1032480005898 putative Mg++ binding site [ion binding]; other site 1032480005899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480005900 nucleotide binding region [chemical binding]; other site 1032480005901 ATP-binding site [chemical binding]; other site 1032480005902 DEAD/H associated; Region: DEAD_assoc; pfam08494 1032480005903 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1032480005904 recombinase A; Provisional; Region: recA; PRK09354 1032480005905 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1032480005906 hexamer interface [polypeptide binding]; other site 1032480005907 Walker A motif; other site 1032480005908 ATP binding site [chemical binding]; other site 1032480005909 Walker B motif; other site 1032480005910 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1032480005911 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1032480005912 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1032480005913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480005914 Zn2+ binding site [ion binding]; other site 1032480005915 Mg2+ binding site [ion binding]; other site 1032480005916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005917 dimer interface [polypeptide binding]; other site 1032480005918 conserved gate region; other site 1032480005919 putative PBP binding loops; other site 1032480005920 ABC-ATPase subunit interface; other site 1032480005921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480005922 dimer interface [polypeptide binding]; other site 1032480005923 conserved gate region; other site 1032480005924 putative PBP binding loops; other site 1032480005925 ABC-ATPase subunit interface; other site 1032480005926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480005927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480005928 substrate binding pocket [chemical binding]; other site 1032480005929 membrane-bound complex binding site; other site 1032480005930 hinge residues; other site 1032480005931 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480005932 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1032480005933 Walker A/P-loop; other site 1032480005934 ATP binding site [chemical binding]; other site 1032480005935 Q-loop/lid; other site 1032480005936 ABC transporter signature motif; other site 1032480005937 Walker B; other site 1032480005938 D-loop; other site 1032480005939 H-loop/switch region; other site 1032480005940 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1032480005941 active site 1032480005942 catalytic residues [active] 1032480005943 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1032480005944 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1032480005945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480005946 FeS/SAM binding site; other site 1032480005947 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480005948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480005949 NAD(P) binding site [chemical binding]; other site 1032480005950 active site 1032480005951 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1032480005952 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1032480005953 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1032480005954 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1032480005955 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1032480005956 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1032480005957 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480005958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480005959 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1032480005960 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1032480005961 HflX GTPase family; Region: HflX; cd01878 1032480005962 G1 box; other site 1032480005963 GTP/Mg2+ binding site [chemical binding]; other site 1032480005964 Switch I region; other site 1032480005965 G2 box; other site 1032480005966 G3 box; other site 1032480005967 Switch II region; other site 1032480005968 G4 box; other site 1032480005969 G5 box; other site 1032480005970 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1032480005971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1032480005972 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1032480005973 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1032480005974 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1032480005975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480005976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480005977 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480005978 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1032480005979 LexA repressor; Validated; Region: PRK00215 1032480005980 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1032480005981 Catalytic site [active] 1032480005982 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1032480005983 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1032480005984 ATP cone domain; Region: ATP-cone; pfam03477 1032480005985 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1032480005986 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1032480005987 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1032480005988 active site 1032480005989 dimer interface [polypeptide binding]; other site 1032480005990 effector binding site; other site 1032480005991 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1032480005992 TSCPD domain; Region: TSCPD; pfam12637 1032480005993 Protease prsW family; Region: PrsW-protease; pfam13367 1032480005994 Predicted permeases [General function prediction only]; Region: COG0679 1032480005995 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480005996 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480005997 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1032480005998 putative ligand binding site [chemical binding]; other site 1032480005999 dimerization interface [polypeptide binding]; other site 1032480006000 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1032480006001 putative active cleft [active] 1032480006002 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480006003 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480006004 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480006005 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480006006 ATP binding site [chemical binding]; other site 1032480006007 substrate binding site [chemical binding]; other site 1032480006008 Class I aldolases; Region: Aldolase_Class_I; cl17187 1032480006009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480006010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480006011 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480006012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006013 dimer interface [polypeptide binding]; other site 1032480006014 conserved gate region; other site 1032480006015 putative PBP binding loops; other site 1032480006016 ABC-ATPase subunit interface; other site 1032480006017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480006018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006019 dimer interface [polypeptide binding]; other site 1032480006020 conserved gate region; other site 1032480006021 putative PBP binding loops; other site 1032480006022 ABC-ATPase subunit interface; other site 1032480006023 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1032480006024 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480006025 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1032480006026 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1032480006027 active site 1032480006028 catalytic site [active] 1032480006029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006030 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1032480006031 tetramerization interface [polypeptide binding]; other site 1032480006032 NAD(P) binding site [chemical binding]; other site 1032480006033 catalytic residues [active] 1032480006034 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480006035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006036 DNA-binding site [nucleotide binding]; DNA binding site 1032480006037 FCD domain; Region: FCD; pfam07729 1032480006038 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1032480006039 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1032480006040 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 1032480006041 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480006042 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1032480006043 ligand binding site [chemical binding]; other site 1032480006044 NAD binding site [chemical binding]; other site 1032480006045 dimerization interface [polypeptide binding]; other site 1032480006046 catalytic site [active] 1032480006047 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480006048 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1032480006049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480006050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480006051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480006052 dimerization interface [polypeptide binding]; other site 1032480006053 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1032480006054 putative phosphoketolase; Provisional; Region: PRK05261 1032480006055 XFP N-terminal domain; Region: XFP_N; pfam09364 1032480006056 XFP C-terminal domain; Region: XFP_C; pfam09363 1032480006057 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1032480006058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480006059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006060 active site 1032480006061 phosphorylation site [posttranslational modification] 1032480006062 intermolecular recognition site; other site 1032480006063 dimerization interface [polypeptide binding]; other site 1032480006064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006065 DNA binding residues [nucleotide binding] 1032480006066 dimerization interface [polypeptide binding]; other site 1032480006067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480006068 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1032480006069 GAF domain; Region: GAF_3; pfam13492 1032480006070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480006071 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1032480006072 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1032480006073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480006074 ATP binding site [chemical binding]; other site 1032480006075 putative Mg++ binding site [ion binding]; other site 1032480006076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480006077 nucleotide binding region [chemical binding]; other site 1032480006078 ATP-binding site [chemical binding]; other site 1032480006079 Helicase associated domain (HA2); Region: HA2; pfam04408 1032480006080 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1032480006081 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1032480006082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480006083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006084 dimer interface [polypeptide binding]; other site 1032480006085 conserved gate region; other site 1032480006086 putative PBP binding loops; other site 1032480006087 ABC-ATPase subunit interface; other site 1032480006088 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1032480006089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006090 dimer interface [polypeptide binding]; other site 1032480006091 conserved gate region; other site 1032480006092 putative PBP binding loops; other site 1032480006093 ABC-ATPase subunit interface; other site 1032480006094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480006095 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480006096 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480006097 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480006098 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480006099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480006100 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480006101 substrate binding site [chemical binding]; other site 1032480006102 ATP binding site [chemical binding]; other site 1032480006103 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480006104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006105 DNA-binding site [nucleotide binding]; DNA binding site 1032480006106 UTRA domain; Region: UTRA; pfam07702 1032480006107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480006108 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480006109 ligand binding site [chemical binding]; other site 1032480006110 dimerization interface [polypeptide binding]; other site 1032480006111 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480006112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480006113 substrate binding site [chemical binding]; other site 1032480006114 ATP binding site [chemical binding]; other site 1032480006115 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480006116 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480006117 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480006118 dimer interface [polypeptide binding]; other site 1032480006119 active site 1032480006120 putative oxidoreductase; Provisional; Region: PRK11579 1032480006121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006122 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480006123 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480006124 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480006125 PAC2 family; Region: PAC2; pfam09754 1032480006126 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1032480006127 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1032480006128 active site 1032480006129 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1032480006130 catalytic triad [active] 1032480006131 dimer interface [polypeptide binding]; other site 1032480006132 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1032480006133 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1032480006134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006135 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480006136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006137 DNA binding residues [nucleotide binding] 1032480006138 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1032480006139 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1032480006140 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480006141 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480006142 Ligand Binding Site [chemical binding]; other site 1032480006143 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1032480006144 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1032480006145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006146 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1032480006147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006148 DNA binding residues [nucleotide binding] 1032480006149 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1032480006150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006151 ATP binding site [chemical binding]; other site 1032480006152 Mg2+ binding site [ion binding]; other site 1032480006153 G-X-G motif; other site 1032480006154 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1032480006155 ATP binding site [chemical binding]; other site 1032480006156 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1032480006157 active site 1032480006158 metal binding site [ion binding]; metal-binding site 1032480006159 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1032480006160 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1032480006161 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1032480006162 putative di-iron ligands [ion binding]; other site 1032480006163 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480006164 putative active site [active] 1032480006165 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1032480006166 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1032480006167 CAP-like domain; other site 1032480006168 active site 1032480006169 primary dimer interface [polypeptide binding]; other site 1032480006170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1032480006171 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480006172 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480006173 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1032480006174 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1032480006175 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480006176 allantoate amidohydrolase; Reviewed; Region: PRK09290 1032480006177 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1032480006178 active site 1032480006179 metal binding site [ion binding]; metal-binding site 1032480006180 dimer interface [polypeptide binding]; other site 1032480006181 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1032480006182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480006183 catalytic residue [active] 1032480006184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480006185 catalytic core [active] 1032480006186 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1032480006187 indole-3-acetamide amidohydrolase; Region: PLN02722 1032480006188 Amidase; Region: Amidase; cl11426 1032480006189 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1032480006190 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1032480006191 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1032480006192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1032480006193 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480006194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006195 DNA-binding site [nucleotide binding]; DNA binding site 1032480006196 FCD domain; Region: FCD; pfam07729 1032480006197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480006198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480006199 OHCU decarboxylase; Region: UraD_2; TIGR03180 1032480006200 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1032480006201 active site 1032480006202 homotetramer interface [polypeptide binding]; other site 1032480006203 urate oxidase; Region: urate_oxi; TIGR03383 1032480006204 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1032480006205 active site 1032480006206 xanthine permease; Region: pbuX; TIGR03173 1032480006207 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1032480006208 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1032480006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1032480006210 CHAD domain; Region: CHAD; pfam05235 1032480006211 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1032480006212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480006213 acyl-activating enzyme (AAE) consensus motif; other site 1032480006214 AMP binding site [chemical binding]; other site 1032480006215 active site 1032480006216 CoA binding site [chemical binding]; other site 1032480006217 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1032480006218 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1032480006219 putative active site [active] 1032480006220 glycerol kinase; Provisional; Region: glpK; PRK00047 1032480006221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480006222 nucleotide binding site [chemical binding]; other site 1032480006223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480006224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480006225 Coenzyme A binding pocket [chemical binding]; other site 1032480006226 CoA binding domain; Region: CoA_binding_2; pfam13380 1032480006227 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1032480006228 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1032480006229 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1032480006230 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1032480006231 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1032480006232 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1032480006233 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1032480006234 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1032480006235 active site residue [active] 1032480006236 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1032480006237 active site residue [active] 1032480006238 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480006239 HNH nucleases; Region: HNHc; smart00507 1032480006240 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1032480006241 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1032480006242 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1032480006243 Protein of unknown function DUF262; Region: DUF262; pfam03235 1032480006244 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1032480006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1032480006246 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1032480006247 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1032480006248 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1032480006249 HNH endonuclease; Region: HNH_2; pfam13391 1032480006250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480006251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480006252 non-specific DNA binding site [nucleotide binding]; other site 1032480006253 salt bridge; other site 1032480006254 sequence-specific DNA binding site [nucleotide binding]; other site 1032480006255 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480006256 active site 1032480006257 NTP binding site [chemical binding]; other site 1032480006258 metal binding triad [ion binding]; metal-binding site 1032480006259 antibiotic binding site [chemical binding]; other site 1032480006260 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480006261 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480006262 ATP binding site [chemical binding]; other site 1032480006263 putative Mg++ binding site [ion binding]; other site 1032480006264 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1032480006265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480006266 nucleotide binding region [chemical binding]; other site 1032480006267 ATP-binding site [chemical binding]; other site 1032480006268 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1032480006269 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1032480006270 RibD C-terminal domain; Region: RibD_C; cl17279 1032480006271 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1032480006272 pentamer interface [polypeptide binding]; other site 1032480006273 dodecaamer interface [polypeptide binding]; other site 1032480006274 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1032480006275 Predicted membrane protein [Function unknown]; Region: COG2860 1032480006276 UPF0126 domain; Region: UPF0126; pfam03458 1032480006277 UPF0126 domain; Region: UPF0126; pfam03458 1032480006278 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1032480006279 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1032480006280 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1032480006281 metal ion-dependent adhesion site (MIDAS); other site 1032480006282 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1032480006283 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1032480006284 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1032480006285 substrate binding site; other site 1032480006286 tetramer interface; other site 1032480006287 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1032480006288 transmembrane helices; other site 1032480006289 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1032480006290 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1032480006291 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1032480006292 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1032480006293 NAD binding site [chemical binding]; other site 1032480006294 substrate binding site [chemical binding]; other site 1032480006295 homodimer interface [polypeptide binding]; other site 1032480006296 active site 1032480006297 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1032480006298 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1032480006299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006300 NAD(P) binding site [chemical binding]; other site 1032480006301 active site 1032480006302 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006304 putative substrate translocation pore; other site 1032480006305 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006306 ferrochelatase; Reviewed; Region: hemH; PRK00035 1032480006307 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1032480006308 C-terminal domain interface [polypeptide binding]; other site 1032480006309 active site 1032480006310 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1032480006311 active site 1032480006312 N-terminal domain interface [polypeptide binding]; other site 1032480006313 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1032480006314 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1032480006315 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1032480006316 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1032480006317 ssDNA binding site; other site 1032480006318 generic binding surface II; other site 1032480006319 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480006320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480006321 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480006322 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480006323 TrkA-N domain; Region: TrkA_N; pfam02254 1032480006324 TrkA-C domain; Region: TrkA_C; pfam02080 1032480006325 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480006326 TrkA-N domain; Region: TrkA_N; pfam02254 1032480006327 TrkA-C domain; Region: TrkA_C; pfam02080 1032480006328 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480006329 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1032480006330 TRAM domain; Region: TRAM; pfam01938 1032480006331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006332 S-adenosylmethionine binding site [chemical binding]; other site 1032480006333 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1032480006334 aconitate hydratase; Validated; Region: PRK09277 1032480006335 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1032480006336 substrate binding site [chemical binding]; other site 1032480006337 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1032480006338 ligand binding site [chemical binding]; other site 1032480006339 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1032480006340 substrate binding site [chemical binding]; other site 1032480006341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480006342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480006344 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480006345 NAD(P) binding site [chemical binding]; other site 1032480006346 active site 1032480006347 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006348 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006349 active site 1032480006350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006351 active site 1032480006352 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1032480006353 MAEBL; Provisional; Region: PTZ00121 1032480006354 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1032480006355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1032480006356 phage tail protein domain; Region: tail_TIGR02242 1032480006357 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1032480006358 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1032480006359 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1032480006360 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1032480006361 Phage protein D [General function prediction only]; Region: COG3500 1032480006362 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1032480006363 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480006364 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480006365 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1032480006366 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1032480006367 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1032480006368 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1032480006369 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1032480006370 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1032480006371 putative NAD(P) binding site [chemical binding]; other site 1032480006372 putative substrate binding site [chemical binding]; other site 1032480006373 catalytic Zn binding site [ion binding]; other site 1032480006374 structural Zn binding site [ion binding]; other site 1032480006375 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1032480006376 DNA binding site [nucleotide binding] 1032480006377 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480006378 AAA domain; Region: AAA_22; pfam13401 1032480006379 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480006380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006381 DNA-binding site [nucleotide binding]; DNA binding site 1032480006382 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1032480006383 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1032480006384 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1032480006385 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480006386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480006387 catalytic residue [active] 1032480006388 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1032480006389 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1032480006390 substrate binding pocket [chemical binding]; other site 1032480006391 catalytic triad [active] 1032480006392 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1032480006393 nucleotide binding site/active site [active] 1032480006394 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480006395 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480006396 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1032480006397 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1032480006398 TPP-binding site; other site 1032480006399 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480006400 PYR/PP interface [polypeptide binding]; other site 1032480006401 dimer interface [polypeptide binding]; other site 1032480006402 TPP binding site [chemical binding]; other site 1032480006403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480006404 Thioredoxin; Region: Thioredoxin_4; cl17273 1032480006405 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1032480006406 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1032480006407 putative active site [active] 1032480006408 redox center [active] 1032480006409 amino acid transporter; Region: 2A0306; TIGR00909 1032480006410 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1032480006411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480006412 trimer interface [polypeptide binding]; other site 1032480006413 oxyanion hole (OAH) forming residues; other site 1032480006414 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1032480006415 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1032480006416 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1032480006417 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480006418 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1032480006419 dimer interface [polypeptide binding]; other site 1032480006420 active site 1032480006421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480006422 dimerization interface [polypeptide binding]; other site 1032480006423 putative DNA binding site [nucleotide binding]; other site 1032480006424 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480006425 putative Zn2+ binding site [ion binding]; other site 1032480006426 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480006427 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1032480006428 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1032480006429 catalytic site [active] 1032480006430 putative active site [active] 1032480006431 putative substrate binding site [chemical binding]; other site 1032480006432 HRDC domain; Region: HRDC; pfam00570 1032480006433 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1032480006434 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1032480006435 substrate binding site [chemical binding]; other site 1032480006436 active site 1032480006437 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1032480006438 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1032480006439 active site 1 [active] 1032480006440 dimer interface [polypeptide binding]; other site 1032480006441 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1032480006442 hexamer interface [polypeptide binding]; other site 1032480006443 active site 2 [active] 1032480006444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1032480006445 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1032480006446 SelR domain; Region: SelR; pfam01641 1032480006447 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1032480006448 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 1032480006449 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1032480006450 DNA photolyase; Region: DNA_photolyase; pfam00875 1032480006451 CAAX protease self-immunity; Region: Abi; pfam02517 1032480006452 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1032480006453 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1032480006454 putative NAD(P) binding site [chemical binding]; other site 1032480006455 putative active site [active] 1032480006456 TspO/MBR family; Region: TspO_MBR; pfam03073 1032480006457 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1032480006458 nucleotide binding site [chemical binding]; other site 1032480006459 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480006460 DinB superfamily; Region: DinB_2; pfam12867 1032480006461 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1032480006462 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1032480006463 hypothetical protein; Provisional; Region: PRK14059 1032480006464 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1032480006465 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1032480006466 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1032480006467 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1032480006468 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1032480006469 putative active site [active] 1032480006470 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1032480006471 active site 1032480006472 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1032480006473 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1032480006474 CysD dimerization site [polypeptide binding]; other site 1032480006475 G1 box; other site 1032480006476 putative GEF interaction site [polypeptide binding]; other site 1032480006477 GTP/Mg2+ binding site [chemical binding]; other site 1032480006478 Switch I region; other site 1032480006479 G2 box; other site 1032480006480 G3 box; other site 1032480006481 Switch II region; other site 1032480006482 G4 box; other site 1032480006483 G5 box; other site 1032480006484 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1032480006485 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1032480006486 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1032480006487 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480006488 Active Sites [active] 1032480006489 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1032480006490 ligand-binding site [chemical binding]; other site 1032480006491 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1032480006492 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480006493 Active Sites [active] 1032480006494 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1032480006495 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480006496 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480006497 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1032480006498 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1032480006499 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1032480006500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006501 catalytic residue [active] 1032480006502 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1032480006503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480006504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006506 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1032480006507 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1032480006508 nucleotide binding site [chemical binding]; other site 1032480006509 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1032480006510 SBD interface [polypeptide binding]; other site 1032480006511 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1032480006512 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1032480006513 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006514 Probable Catalytic site; other site 1032480006515 metal-binding site 1032480006516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006517 active site 1032480006518 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480006520 active site 1032480006521 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1032480006522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480006523 UDP-galactopyranose mutase; Region: GLF; pfam03275 1032480006524 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480006525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480006526 active site 1032480006527 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1032480006528 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480006529 transketolase; Reviewed; Region: PRK05899 1032480006530 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480006531 TPP-binding site [chemical binding]; other site 1032480006532 dimer interface [polypeptide binding]; other site 1032480006533 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1032480006534 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480006535 PYR/PP interface [polypeptide binding]; other site 1032480006536 dimer interface [polypeptide binding]; other site 1032480006537 TPP binding site [chemical binding]; other site 1032480006538 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480006539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006540 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006541 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480006542 short chain dehydrogenase; Provisional; Region: PRK06198 1032480006543 classical (c) SDRs; Region: SDR_c; cd05233 1032480006544 NAD(P) binding site [chemical binding]; other site 1032480006545 active site 1032480006546 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480006547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480006548 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1032480006549 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480006550 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1032480006551 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1032480006552 Bacterial transcriptional regulator; Region: IclR; pfam01614 1032480006553 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480006554 Ligand Binding Site [chemical binding]; other site 1032480006555 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480006556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006557 putative substrate translocation pore; other site 1032480006558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006559 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006560 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006561 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006562 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006563 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480006564 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480006565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006566 DNA-binding site [nucleotide binding]; DNA binding site 1032480006567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480006568 H-loop/switch region; other site 1032480006569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480006570 Transposase; Region: HTH_Tnp_1; cl17663 1032480006571 putative transposase OrfB; Reviewed; Region: PHA02517 1032480006572 HTH-like domain; Region: HTH_21; pfam13276 1032480006573 Integrase core domain; Region: rve; pfam00665 1032480006574 Integrase core domain; Region: rve_3; pfam13683 1032480006575 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1032480006576 Walker A/P-loop; other site 1032480006577 ATP binding site [chemical binding]; other site 1032480006578 ABC transporter; Region: ABC_tran; pfam00005 1032480006579 Q-loop/lid; other site 1032480006580 ABC transporter signature motif; other site 1032480006581 Walker B; other site 1032480006582 D-loop; other site 1032480006583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1032480006584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480006585 TM-ABC transporter signature motif; other site 1032480006586 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1032480006587 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480006588 putative ligand binding site [chemical binding]; other site 1032480006589 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1032480006590 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480006591 PYR/PP interface [polypeptide binding]; other site 1032480006592 dimer interface [polypeptide binding]; other site 1032480006593 TPP binding site [chemical binding]; other site 1032480006594 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480006595 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1032480006596 TPP-binding site [chemical binding]; other site 1032480006597 KduI/IolB family; Region: KduI; pfam04962 1032480006598 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 1032480006599 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1032480006600 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1032480006601 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1032480006602 active site 1032480006603 dimer interface [polypeptide binding]; other site 1032480006604 motif 1; other site 1032480006605 motif 2; other site 1032480006606 motif 3; other site 1032480006607 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1032480006608 anticodon binding site; other site 1032480006609 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1032480006610 nucleotide binding site/active site [active] 1032480006611 HIT family signature motif; other site 1032480006612 catalytic residue [active] 1032480006613 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1032480006614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1032480006615 putative acyl-acceptor binding pocket; other site 1032480006616 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480006617 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1032480006618 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1032480006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1032480006620 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480006621 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1032480006622 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480006623 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1032480006624 lipoyl attachment site [posttranslational modification]; other site 1032480006625 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1032480006626 Double zinc ribbon; Region: DZR; pfam12773 1032480006627 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480006628 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480006629 phosphopeptide binding site; other site 1032480006630 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480006631 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480006632 DNA binding residues [nucleotide binding] 1032480006633 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1032480006634 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1032480006635 DNA binding residues [nucleotide binding] 1032480006636 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480006637 putative dimer interface [polypeptide binding]; other site 1032480006638 glycine dehydrogenase; Provisional; Region: PRK05367 1032480006639 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1032480006640 tetramer interface [polypeptide binding]; other site 1032480006641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006642 catalytic residue [active] 1032480006643 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1032480006644 tetramer interface [polypeptide binding]; other site 1032480006645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006646 catalytic residue [active] 1032480006647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006649 maltose O-acetyltransferase; Provisional; Region: PRK10092 1032480006650 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480006651 active site 1032480006652 substrate binding site [chemical binding]; other site 1032480006653 trimer interface [polypeptide binding]; other site 1032480006654 CoA binding site [chemical binding]; other site 1032480006655 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1032480006656 EamA-like transporter family; Region: EamA; pfam00892 1032480006657 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1032480006658 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1032480006659 GAF domain; Region: GAF; pfam01590 1032480006660 ANTAR domain; Region: ANTAR; pfam03861 1032480006661 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480006662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006663 DNA-binding site [nucleotide binding]; DNA binding site 1032480006664 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1032480006665 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1032480006666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006667 ATP binding site [chemical binding]; other site 1032480006668 Mg2+ binding site [ion binding]; other site 1032480006669 G-X-G motif; other site 1032480006670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480006671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006672 active site 1032480006673 phosphorylation site [posttranslational modification] 1032480006674 intermolecular recognition site; other site 1032480006675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006676 DNA binding residues [nucleotide binding] 1032480006677 dimerization interface [polypeptide binding]; other site 1032480006678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006680 putative substrate translocation pore; other site 1032480006681 arginine deiminase; Provisional; Region: PRK01388 1032480006682 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1032480006683 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480006684 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1032480006685 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1032480006686 tetrameric interface [polypeptide binding]; other site 1032480006687 NAD binding site [chemical binding]; other site 1032480006688 catalytic residues [active] 1032480006689 hypothetical protein; Provisional; Region: PRK06062 1032480006690 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480006691 inhibitor-cofactor binding pocket; inhibition site 1032480006692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480006693 catalytic residue [active] 1032480006694 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480006695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006696 DNA-binding site [nucleotide binding]; DNA binding site 1032480006697 FCD domain; Region: FCD; pfam07729 1032480006698 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006699 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1032480006700 NAD(P) binding site [chemical binding]; other site 1032480006701 catalytic residues [active] 1032480006702 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006703 Proline racemase; Region: Pro_racemase; pfam05544 1032480006704 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480006705 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480006706 inhibitor site; inhibition site 1032480006707 active site 1032480006708 dimer interface [polypeptide binding]; other site 1032480006709 catalytic residue [active] 1032480006710 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1032480006711 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1032480006712 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006713 Proline racemase; Region: Pro_racemase; pfam05544 1032480006714 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1032480006715 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480006716 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006717 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1032480006718 tetrameric interface [polypeptide binding]; other site 1032480006719 NAD binding site [chemical binding]; other site 1032480006720 catalytic residues [active] 1032480006721 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1032480006722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1032480006723 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480006724 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1032480006725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480006726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480006727 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1032480006728 putative dimerization interface [polypeptide binding]; other site 1032480006729 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1032480006730 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1032480006731 DNA binding residues [nucleotide binding] 1032480006732 TOBE domain; Region: TOBE; cl01440 1032480006733 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1032480006734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480006735 Walker A/P-loop; other site 1032480006736 ATP binding site [chemical binding]; other site 1032480006737 Q-loop/lid; other site 1032480006738 ABC transporter signature motif; other site 1032480006739 Walker B; other site 1032480006740 D-loop; other site 1032480006741 H-loop/switch region; other site 1032480006742 TOBE domain; Region: TOBE; cl01440 1032480006743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1032480006744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480006745 putative PBP binding loops; other site 1032480006746 ABC-ATPase subunit interface; other site 1032480006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1032480006748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1032480006749 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480006750 Ligand Binding Site [chemical binding]; other site 1032480006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006752 putative substrate translocation pore; other site 1032480006753 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480006754 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1032480006755 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1032480006756 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480006757 Ligand Binding Site [chemical binding]; other site 1032480006758 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1032480006759 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1032480006760 Ligand binding site [chemical binding]; other site 1032480006761 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1032480006762 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1032480006763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1032480006764 phosphate binding site [ion binding]; other site 1032480006765 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480006766 NAD(P) binding site [chemical binding]; other site 1032480006767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006768 DNA-binding site [nucleotide binding]; DNA binding site 1032480006769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480006770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480006771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1032480006772 dimerization interface [polypeptide binding]; other site 1032480006773 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480006774 classical (c) SDRs; Region: SDR_c; cd05233 1032480006775 NAD(P) binding site [chemical binding]; other site 1032480006776 active site 1032480006777 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480006778 classical (c) SDRs; Region: SDR_c; cd05233 1032480006779 NAD(P) binding site [chemical binding]; other site 1032480006780 active site 1032480006781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1032480006782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480006783 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480006784 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1032480006785 inhibitor site; inhibition site 1032480006786 active site 1032480006787 dimer interface [polypeptide binding]; other site 1032480006788 catalytic residue [active] 1032480006789 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1032480006790 Proline racemase; Region: Pro_racemase; pfam05544 1032480006791 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480006792 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480006793 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1032480006794 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1032480006795 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1032480006796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006797 DNA-binding site [nucleotide binding]; DNA binding site 1032480006798 FCD domain; Region: FCD; pfam07729 1032480006799 short chain dehydrogenase; Provisional; Region: PRK06197 1032480006800 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480006801 putative NAD(P) binding site [chemical binding]; other site 1032480006802 active site 1032480006803 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1032480006804 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1032480006805 THF binding site; other site 1032480006806 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1032480006807 substrate binding site [chemical binding]; other site 1032480006808 THF binding site; other site 1032480006809 zinc-binding site [ion binding]; other site 1032480006810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480006811 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480006812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480006813 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480006814 Walker A/P-loop; other site 1032480006815 ATP binding site [chemical binding]; other site 1032480006816 Q-loop/lid; other site 1032480006817 ABC transporter signature motif; other site 1032480006818 Walker B; other site 1032480006819 D-loop; other site 1032480006820 H-loop/switch region; other site 1032480006821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480006822 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480006823 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480006824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006825 active site 1032480006826 phosphorylation site [posttranslational modification] 1032480006827 intermolecular recognition site; other site 1032480006828 dimerization interface [polypeptide binding]; other site 1032480006829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480006830 DNA binding site [nucleotide binding] 1032480006831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480006832 HAMP domain; Region: HAMP; pfam00672 1032480006833 dimerization interface [polypeptide binding]; other site 1032480006834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480006835 dimer interface [polypeptide binding]; other site 1032480006836 phosphorylation site [posttranslational modification] 1032480006837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006838 ATP binding site [chemical binding]; other site 1032480006839 Mg2+ binding site [ion binding]; other site 1032480006840 G-X-G motif; other site 1032480006841 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480006842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480006843 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480006844 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006846 DNA binding residues [nucleotide binding] 1032480006847 Family description; Region: VCBS; pfam13517 1032480006848 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1032480006849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480006850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480006851 active site 1032480006852 catalytic tetrad [active] 1032480006853 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480006854 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1032480006855 NAD(P) binding site [chemical binding]; other site 1032480006856 catalytic residues [active] 1032480006857 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1032480006858 putative metal binding site [ion binding]; other site 1032480006859 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1032480006860 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480006861 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1032480006862 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1032480006863 Walker A/P-loop; other site 1032480006864 ATP binding site [chemical binding]; other site 1032480006865 Q-loop/lid; other site 1032480006866 ABC transporter signature motif; other site 1032480006867 Walker B; other site 1032480006868 D-loop; other site 1032480006869 H-loop/switch region; other site 1032480006870 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1032480006871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480006872 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1032480006873 Walker A/P-loop; other site 1032480006874 ATP binding site [chemical binding]; other site 1032480006875 Q-loop/lid; other site 1032480006876 ABC transporter signature motif; other site 1032480006877 Walker B; other site 1032480006878 D-loop; other site 1032480006879 H-loop/switch region; other site 1032480006880 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1032480006881 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1032480006882 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1032480006883 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1032480006884 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1032480006885 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1032480006886 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1032480006887 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1032480006888 catalytic residues [active] 1032480006889 dimer interface [polypeptide binding]; other site 1032480006890 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480006891 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480006892 intersubunit interface [polypeptide binding]; other site 1032480006893 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480006894 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480006895 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1032480006896 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480006897 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480006898 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1032480006899 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480006900 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480006901 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1032480006902 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480006903 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480006904 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1032480006905 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1032480006906 metal binding site [ion binding]; metal-binding site 1032480006907 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480006908 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1032480006909 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1032480006910 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480006911 ABC-ATPase subunit interface; other site 1032480006912 dimer interface [polypeptide binding]; other site 1032480006913 putative PBP binding regions; other site 1032480006914 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1032480006915 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1032480006916 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1032480006917 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1032480006918 Beta propeller domain; Region: Beta_propel; pfam09826 1032480006919 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480006920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480006921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480006922 DNA binding residues [nucleotide binding] 1032480006923 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480006924 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480006925 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480006926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480006927 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1032480006928 substrate binding site [chemical binding]; other site 1032480006929 ATP binding site [chemical binding]; other site 1032480006930 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1032480006931 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1032480006932 active site 1032480006933 intersubunit interface [polypeptide binding]; other site 1032480006934 catalytic residue [active] 1032480006935 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1032480006936 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480006937 TrkA-N domain; Region: TrkA_N; pfam02254 1032480006938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480006940 Predicted transcriptional regulators [Transcription]; Region: COG1733 1032480006941 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1032480006942 Survival protein SurE; Region: SurE; cl00448 1032480006943 AAA ATPase domain; Region: AAA_16; pfam13191 1032480006944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480006945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480006946 DNA binding residues [nucleotide binding] 1032480006947 dimerization interface [polypeptide binding]; other site 1032480006948 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006949 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006950 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006951 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006952 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006953 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006954 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1032480006955 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480006956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480006957 non-specific DNA binding site [nucleotide binding]; other site 1032480006958 salt bridge; other site 1032480006959 sequence-specific DNA binding site [nucleotide binding]; other site 1032480006960 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1032480006961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480006962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480006963 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480006964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480006965 putative substrate translocation pore; other site 1032480006966 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1032480006967 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1032480006968 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1032480006969 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1032480006970 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1032480006971 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1032480006972 nudix motif; other site 1032480006973 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480006974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480006975 DNA-binding site [nucleotide binding]; DNA binding site 1032480006976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480006977 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480006978 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480006979 hypothetical protein; Provisional; Region: PRK07588 1032480006980 hypothetical protein; Provisional; Region: PRK08317 1032480006981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480006982 S-adenosylmethionine binding site [chemical binding]; other site 1032480006983 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1032480006984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480006985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480006986 intermolecular recognition site; other site 1032480006987 active site 1032480006988 dimerization interface [polypeptide binding]; other site 1032480006989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480006990 DNA binding site [nucleotide binding] 1032480006991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480006992 dimer interface [polypeptide binding]; other site 1032480006993 phosphorylation site [posttranslational modification] 1032480006994 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1032480006995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480006996 ATP binding site [chemical binding]; other site 1032480006997 Mg2+ binding site [ion binding]; other site 1032480006998 G-X-G motif; other site 1032480006999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480007000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480007001 NAD(P) binding site [chemical binding]; other site 1032480007002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480007003 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1032480007004 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480007005 homotetrameric interface [polypeptide binding]; other site 1032480007006 putative active site [active] 1032480007007 metal binding site [ion binding]; metal-binding site 1032480007008 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1032480007009 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1032480007010 oligomer interface [polypeptide binding]; other site 1032480007011 metal binding site [ion binding]; metal-binding site 1032480007012 metal binding site [ion binding]; metal-binding site 1032480007013 putative Cl binding site [ion binding]; other site 1032480007014 basic sphincter; other site 1032480007015 hydrophobic gate; other site 1032480007016 periplasmic entrance; other site 1032480007017 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480007018 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480007019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480007020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480007021 active site 1032480007022 catalytic tetrad [active] 1032480007023 AAA ATPase domain; Region: AAA_16; pfam13191 1032480007024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007026 DNA binding residues [nucleotide binding] 1032480007027 dimerization interface [polypeptide binding]; other site 1032480007028 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1032480007029 Predicted membrane protein [Function unknown]; Region: COG2364 1032480007030 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480007031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480007032 DNA-binding site [nucleotide binding]; DNA binding site 1032480007033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480007034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007035 homodimer interface [polypeptide binding]; other site 1032480007036 catalytic residue [active] 1032480007037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480007038 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480007039 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1032480007040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480007041 non-specific DNA binding site [nucleotide binding]; other site 1032480007042 salt bridge; other site 1032480007043 sequence-specific DNA binding site [nucleotide binding]; other site 1032480007044 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1032480007045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480007046 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1032480007047 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1032480007048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480007049 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480007050 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480007051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480007052 non-specific DNA binding site [nucleotide binding]; other site 1032480007053 salt bridge; other site 1032480007054 sequence-specific DNA binding site [nucleotide binding]; other site 1032480007055 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1032480007056 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1032480007057 putative active site [active] 1032480007058 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1032480007059 RHS Repeat; Region: RHS_repeat; pfam05593 1032480007060 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1032480007061 pyridoxamine kinase; Validated; Region: PRK05756 1032480007062 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1032480007063 dimer interface [polypeptide binding]; other site 1032480007064 pyridoxal binding site [chemical binding]; other site 1032480007065 ATP binding site [chemical binding]; other site 1032480007066 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1032480007067 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1032480007068 putative active site [active] 1032480007069 catalytic site [active] 1032480007070 putative metal binding site [ion binding]; other site 1032480007071 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1032480007072 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1032480007073 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1032480007074 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480007075 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1032480007076 Ligand binding site; other site 1032480007077 Putative Catalytic site; other site 1032480007078 DXD motif; other site 1032480007079 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1032480007080 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1032480007081 putative active site [active] 1032480007082 catalytic triad [active] 1032480007083 putative dimer interface [polypeptide binding]; other site 1032480007084 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1032480007085 nudix motif; other site 1032480007086 Homeodomain-like domain; Region: HTH_23; pfam13384 1032480007087 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480007088 Homeodomain-like domain; Region: HTH_32; pfam13565 1032480007089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1032480007090 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1032480007091 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 1032480007092 putative transposase OrfB; Reviewed; Region: PHA02517 1032480007093 HTH-like domain; Region: HTH_21; pfam13276 1032480007094 Integrase core domain; Region: rve; pfam00665 1032480007095 Integrase core domain; Region: rve_3; pfam13683 1032480007096 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1032480007097 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480007098 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480007099 active site 1032480007100 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1032480007101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480007102 putative DNA binding site [nucleotide binding]; other site 1032480007103 putative Zn2+ binding site [ion binding]; other site 1032480007104 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480007105 5'-3' exonuclease; Region: 53EXOc; smart00475 1032480007106 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1032480007107 active site 1032480007108 metal binding site 1 [ion binding]; metal-binding site 1032480007109 putative 5' ssDNA interaction site; other site 1032480007110 metal binding site 3; metal-binding site 1032480007111 metal binding site 2 [ion binding]; metal-binding site 1032480007112 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1032480007113 putative DNA binding site [nucleotide binding]; other site 1032480007114 putative metal binding site [ion binding]; other site 1032480007115 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1032480007116 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1032480007117 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1032480007118 homodimer interface [polypeptide binding]; other site 1032480007119 substrate-cofactor binding pocket; other site 1032480007120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007121 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1032480007122 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480007123 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1032480007124 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1032480007125 active site 1032480007126 homodimer interface [polypeptide binding]; other site 1032480007127 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1032480007128 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 1032480007129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480007130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480007131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007132 S-adenosylmethionine binding site [chemical binding]; other site 1032480007133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480007134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480007135 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1032480007136 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1032480007137 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1032480007138 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480007139 Ligand binding site; other site 1032480007140 Putative Catalytic site; other site 1032480007141 DXD motif; other site 1032480007142 Predicted membrane protein [Function unknown]; Region: COG2246 1032480007143 GtrA-like protein; Region: GtrA; pfam04138 1032480007144 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1032480007145 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1032480007146 inhibitor-cofactor binding pocket; inhibition site 1032480007147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007148 catalytic residue [active] 1032480007149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007151 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480007153 active site 1032480007154 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1032480007155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1032480007156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480007157 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1032480007158 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1032480007159 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1032480007160 putative trimer interface [polypeptide binding]; other site 1032480007161 putative active site [active] 1032480007162 putative substrate binding site [chemical binding]; other site 1032480007163 putative CoA binding site [chemical binding]; other site 1032480007164 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480007165 active site 1032480007166 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1032480007167 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480007168 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1032480007169 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1032480007170 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1032480007171 substrate binding site; other site 1032480007172 dimer interface; other site 1032480007173 short chain dehydrogenase; Provisional; Region: PRK06198 1032480007174 classical (c) SDRs; Region: SDR_c; cd05233 1032480007175 NAD(P) binding site [chemical binding]; other site 1032480007176 active site 1032480007177 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480007178 putative catalytic site [active] 1032480007179 putative metal binding site [ion binding]; other site 1032480007180 putative phosphate binding site [ion binding]; other site 1032480007181 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480007182 putative catalytic site [active] 1032480007183 putative metal binding site [ion binding]; other site 1032480007184 putative phosphate binding site [ion binding]; other site 1032480007185 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480007186 putative catalytic site [active] 1032480007187 putative metal binding site [ion binding]; other site 1032480007188 putative phosphate binding site [ion binding]; other site 1032480007189 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1032480007190 diiron binding motif [ion binding]; other site 1032480007191 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1032480007192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1032480007193 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480007194 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480007195 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480007196 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480007197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480007198 dimerization interface [polypeptide binding]; other site 1032480007199 putative DNA binding site [nucleotide binding]; other site 1032480007200 putative Zn2+ binding site [ion binding]; other site 1032480007201 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480007202 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480007203 active site 1032480007204 catalytic tetrad [active] 1032480007205 Carboxylesterase family; Region: COesterase; pfam00135 1032480007206 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1032480007207 substrate binding pocket [chemical binding]; other site 1032480007208 catalytic triad [active] 1032480007209 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480007210 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480007211 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1032480007212 Cytochrome P450; Region: p450; cl12078 1032480007213 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1032480007214 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1032480007215 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1032480007216 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1032480007217 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480007218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007219 putative substrate translocation pore; other site 1032480007220 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480007221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480007222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007223 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480007224 GTP-binding protein Der; Reviewed; Region: PRK03003 1032480007225 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1032480007226 G1 box; other site 1032480007227 GTP/Mg2+ binding site [chemical binding]; other site 1032480007228 Switch I region; other site 1032480007229 G2 box; other site 1032480007230 Switch II region; other site 1032480007231 G3 box; other site 1032480007232 G4 box; other site 1032480007233 G5 box; other site 1032480007234 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1032480007235 G1 box; other site 1032480007236 GTP/Mg2+ binding site [chemical binding]; other site 1032480007237 Switch I region; other site 1032480007238 G2 box; other site 1032480007239 G3 box; other site 1032480007240 Switch II region; other site 1032480007241 G4 box; other site 1032480007242 G5 box; other site 1032480007243 cytidylate kinase; Provisional; Region: cmk; PRK00023 1032480007244 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1032480007245 CMP-binding site; other site 1032480007246 The sites determining sugar specificity; other site 1032480007247 prephenate dehydrogenase; Validated; Region: PRK06545 1032480007248 prephenate dehydrogenase; Validated; Region: PRK08507 1032480007249 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480007250 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1032480007251 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1032480007252 active site 1032480007253 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1032480007254 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1032480007255 active site 1032480007256 Pup-like protein; Region: Pup; pfam05639 1032480007257 Pup-ligase protein; Region: Pup_ligase; cl15463 1032480007258 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1032480007259 proteasome ATPase; Region: pup_AAA; TIGR03689 1032480007260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480007261 Walker A motif; other site 1032480007262 ATP binding site [chemical binding]; other site 1032480007263 Walker B motif; other site 1032480007264 arginine finger; other site 1032480007265 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1032480007266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007267 S-adenosylmethionine binding site [chemical binding]; other site 1032480007268 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1032480007269 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480007270 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1032480007271 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480007272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007273 motif II; other site 1032480007274 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1032480007275 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1032480007276 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1032480007277 substrate binding pocket [chemical binding]; other site 1032480007278 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1032480007279 B12 binding site [chemical binding]; other site 1032480007280 cobalt ligand [ion binding]; other site 1032480007281 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1032480007282 PAC2 family; Region: PAC2; pfam09754 1032480007283 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1032480007284 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1032480007285 substrate binding site [chemical binding]; other site 1032480007286 hexamer interface [polypeptide binding]; other site 1032480007287 metal binding site [ion binding]; metal-binding site 1032480007288 acetylornithine deacetylase; Provisional; Region: PRK07522 1032480007289 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1032480007290 metal binding site [ion binding]; metal-binding site 1032480007291 putative dimer interface [polypeptide binding]; other site 1032480007292 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1032480007293 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1032480007294 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1032480007295 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1032480007296 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1032480007297 putative active site [active] 1032480007298 substrate binding site [chemical binding]; other site 1032480007299 putative cosubstrate binding site; other site 1032480007300 catalytic site [active] 1032480007301 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1032480007302 substrate binding site [chemical binding]; other site 1032480007303 primosome assembly protein PriA; Provisional; Region: PRK14873 1032480007304 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1032480007305 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1032480007306 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1032480007307 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1032480007308 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1032480007309 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1032480007310 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1032480007311 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1032480007312 Flavoprotein; Region: Flavoprotein; pfam02441 1032480007313 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1032480007314 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1032480007315 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1032480007316 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1032480007317 catalytic site [active] 1032480007318 G-X2-G-X-G-K; other site 1032480007319 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1032480007320 active site 1032480007321 dimer interface [polypeptide binding]; other site 1032480007322 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1032480007323 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1032480007324 quinone interaction residues [chemical binding]; other site 1032480007325 active site 1032480007326 catalytic residues [active] 1032480007327 FMN binding site [chemical binding]; other site 1032480007328 substrate binding site [chemical binding]; other site 1032480007329 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1032480007330 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480007331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480007332 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1032480007333 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480007334 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480007335 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1032480007336 IMP binding site; other site 1032480007337 dimer interface [polypeptide binding]; other site 1032480007338 interdomain contacts; other site 1032480007339 partial ornithine binding site; other site 1032480007340 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1032480007341 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1032480007342 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1032480007343 catalytic site [active] 1032480007344 subunit interface [polypeptide binding]; other site 1032480007345 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480007346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007348 transcription antitermination factor NusB; Region: nusB; TIGR01951 1032480007349 putative RNA binding site [nucleotide binding]; other site 1032480007350 elongation factor P; Validated; Region: PRK00529 1032480007351 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1032480007352 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1032480007353 RNA binding site [nucleotide binding]; other site 1032480007354 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1032480007355 RNA binding site [nucleotide binding]; other site 1032480007356 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1032480007357 active site 1032480007358 dimer interface [polypeptide binding]; other site 1032480007359 metal binding site [ion binding]; metal-binding site 1032480007360 shikimate kinase; Reviewed; Region: aroK; PRK00131 1032480007361 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1032480007362 ADP binding site [chemical binding]; other site 1032480007363 magnesium binding site [ion binding]; other site 1032480007364 putative shikimate binding site; other site 1032480007365 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1032480007366 chorismate synthase; Validated; Region: PRK05382 1032480007367 Tetramer interface [polypeptide binding]; other site 1032480007368 active site 1032480007369 FMN-binding site [chemical binding]; other site 1032480007370 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1032480007371 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480007372 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480007373 shikimate binding site; other site 1032480007374 NAD(P) binding site [chemical binding]; other site 1032480007375 YceG-like family; Region: YceG; pfam02618 1032480007376 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1032480007377 dimerization interface [polypeptide binding]; other site 1032480007378 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1032480007379 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1032480007380 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1032480007381 motif 1; other site 1032480007382 active site 1032480007383 motif 2; other site 1032480007384 motif 3; other site 1032480007385 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1032480007386 recombination factor protein RarA; Reviewed; Region: PRK13342 1032480007387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480007388 Walker A motif; other site 1032480007389 ATP binding site [chemical binding]; other site 1032480007390 Walker B motif; other site 1032480007391 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1032480007392 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1032480007393 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1032480007394 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1032480007395 dimer interface [polypeptide binding]; other site 1032480007396 anticodon binding site; other site 1032480007397 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1032480007398 homodimer interface [polypeptide binding]; other site 1032480007399 motif 1; other site 1032480007400 active site 1032480007401 motif 2; other site 1032480007402 GAD domain; Region: GAD; pfam02938 1032480007403 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1032480007404 active site 1032480007405 motif 3; other site 1032480007406 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1032480007407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1032480007408 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1032480007409 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1032480007410 dimer interface [polypeptide binding]; other site 1032480007411 motif 1; other site 1032480007412 active site 1032480007413 motif 2; other site 1032480007414 motif 3; other site 1032480007415 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1032480007416 anticodon binding site; other site 1032480007417 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1032480007418 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480007419 putative active site [active] 1032480007420 putative NTP binding site [chemical binding]; other site 1032480007421 putative nucleic acid binding site [nucleotide binding]; other site 1032480007422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480007423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480007424 nucleotide binding site [chemical binding]; other site 1032480007425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1032480007426 DNA-binding site [nucleotide binding]; DNA binding site 1032480007427 RNA-binding motif; other site 1032480007428 aspartate aminotransferase; Provisional; Region: PRK06836 1032480007429 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1032480007430 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480007431 B12 binding site [chemical binding]; other site 1032480007432 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1032480007433 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1032480007434 predicted active site [active] 1032480007435 catalytic triad [active] 1032480007436 AAA domain; Region: AAA_14; pfam13173 1032480007437 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480007438 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1032480007439 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1032480007440 active site 1032480007441 multimer interface [polypeptide binding]; other site 1032480007442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1032480007443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480007444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480007446 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1032480007447 classical (c) SDRs; Region: SDR_c; cd05233 1032480007448 NAD(P) binding site [chemical binding]; other site 1032480007449 active site 1032480007450 glycogen branching enzyme; Provisional; Region: PRK14705 1032480007451 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480007452 CoenzymeA binding site [chemical binding]; other site 1032480007453 subunit interaction site [polypeptide binding]; other site 1032480007454 PHB binding site; other site 1032480007455 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480007456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480007457 Walker A/P-loop; other site 1032480007458 ATP binding site [chemical binding]; other site 1032480007459 Q-loop/lid; other site 1032480007460 ABC transporter signature motif; other site 1032480007461 Walker B; other site 1032480007462 D-loop; other site 1032480007463 H-loop/switch region; other site 1032480007464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480007465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480007466 Walker A/P-loop; other site 1032480007467 ATP binding site [chemical binding]; other site 1032480007468 Q-loop/lid; other site 1032480007469 ABC transporter signature motif; other site 1032480007470 Walker B; other site 1032480007471 D-loop; other site 1032480007472 H-loop/switch region; other site 1032480007473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480007474 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1032480007475 Sulfatase; Region: Sulfatase; pfam00884 1032480007476 Sulfatase; Region: Sulfatase; cl17466 1032480007477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480007478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480007479 dimer interface [polypeptide binding]; other site 1032480007480 conserved gate region; other site 1032480007481 putative PBP binding loops; other site 1032480007482 ABC-ATPase subunit interface; other site 1032480007483 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480007484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480007485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480007486 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1032480007487 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480007488 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1032480007489 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1032480007490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480007491 Walker A motif; other site 1032480007492 ATP binding site [chemical binding]; other site 1032480007493 Walker B motif; other site 1032480007494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007496 DNA binding residues [nucleotide binding] 1032480007497 dimerization interface [polypeptide binding]; other site 1032480007498 EamA-like transporter family; Region: EamA; pfam00892 1032480007499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480007500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1032480007501 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480007502 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480007503 active site 1032480007504 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480007505 arsenical-resistance protein; Region: acr3; TIGR00832 1032480007506 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480007507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007508 S-adenosylmethionine binding site [chemical binding]; other site 1032480007509 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480007510 dimerization interface [polypeptide binding]; other site 1032480007511 putative DNA binding site [nucleotide binding]; other site 1032480007512 putative Zn2+ binding site [ion binding]; other site 1032480007513 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1032480007514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480007515 Coenzyme A binding pocket [chemical binding]; other site 1032480007516 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1032480007517 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1032480007518 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480007519 homotrimer interaction site [polypeptide binding]; other site 1032480007520 putative active site [active] 1032480007521 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1032480007522 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1032480007523 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1032480007524 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1032480007525 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1032480007526 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1032480007527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480007528 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1032480007529 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1032480007530 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1032480007531 putative active site; other site 1032480007532 catalytic residue [active] 1032480007533 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 1032480007534 3-dehydroquinate synthase; Provisional; Region: PRK02290 1032480007535 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1032480007536 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480007537 acyl-activating enzyme (AAE) consensus motif; other site 1032480007538 AMP binding site [chemical binding]; other site 1032480007539 active site 1032480007540 CoA binding site [chemical binding]; other site 1032480007541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480007542 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1032480007543 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1032480007544 nucleophilic elbow; other site 1032480007545 catalytic triad; other site 1032480007546 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480007547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480007548 potential frameshift: common BLAST hit: gi|255531923|ref|YP_003092295.1| polysaccharide deacetylase 1032480007549 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480007550 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1032480007551 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480007552 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1032480007553 putative active site [active] 1032480007554 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1032480007555 Core-2/I-Branching enzyme; Region: Branch; pfam02485 1032480007556 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1032480007557 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1032480007558 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1032480007559 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480007560 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1032480007561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480007562 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1032480007563 active site 1032480007564 catalytic residues [active] 1032480007565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480007566 dimerization interface [polypeptide binding]; other site 1032480007567 putative DNA binding site [nucleotide binding]; other site 1032480007568 putative Zn2+ binding site [ion binding]; other site 1032480007569 Cation efflux family; Region: Cation_efflux; cl00316 1032480007570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007572 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007573 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007574 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007575 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007579 potential frameshift: common BLAST hit: gi|134101071|ref|YP_001106732.1| sugar phosphate isomerase/epimerase 1032480007580 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480007581 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480007582 HNH nucleases; Region: HNHc; smart00507 1032480007583 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1032480007584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480007585 active site 1032480007586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480007587 putative glycosyl transferase; Provisional; Region: PRK10073 1032480007588 active site 1032480007589 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1032480007590 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1032480007591 active site 1032480007592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480007593 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480007594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480007595 active site 1032480007596 potential frameshift: common BLAST hit: gi|312194019|ref|YP_004014080.1| glycosyl transferase 2 1032480007597 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1032480007598 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1032480007599 Ligand binding site; other site 1032480007600 Putative Catalytic site; other site 1032480007601 DXD motif; other site 1032480007602 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1032480007603 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1032480007604 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480007605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480007606 DNA-binding site [nucleotide binding]; DNA binding site 1032480007607 FCD domain; Region: FCD; pfam07729 1032480007608 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480007609 ABC-ATPase subunit interface; other site 1032480007610 dimer interface [polypeptide binding]; other site 1032480007611 putative PBP binding regions; other site 1032480007612 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1032480007613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480007614 ABC-ATPase subunit interface; other site 1032480007615 dimer interface [polypeptide binding]; other site 1032480007616 putative PBP binding regions; other site 1032480007617 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480007618 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480007619 siderophore binding site; other site 1032480007620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007621 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1032480007622 NAD(P) binding site [chemical binding]; other site 1032480007623 active site 1032480007624 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1032480007625 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1032480007626 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1032480007627 acyl-activating enzyme (AAE) consensus motif; other site 1032480007628 active site 1032480007629 AMP binding site [chemical binding]; other site 1032480007630 substrate binding site [chemical binding]; other site 1032480007631 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1032480007632 Isochorismatase family; Region: Isochorismatase; pfam00857 1032480007633 catalytic triad [active] 1032480007634 conserved cis-peptide bond; other site 1032480007635 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1032480007636 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1032480007637 acyl-activating enzyme (AAE) consensus motif; other site 1032480007638 AMP binding site [chemical binding]; other site 1032480007639 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1032480007640 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1032480007641 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1032480007642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007643 putative substrate translocation pore; other site 1032480007644 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1032480007645 potential frameshift: common BLAST hit: gi|284029502|ref|YP_003379433.1| Bcr/CflA subfamily drug resistance transporter 1032480007646 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480007647 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1032480007648 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1032480007649 catalytic residues [active] 1032480007650 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1032480007651 putative active site [active] 1032480007652 redox center [active] 1032480007653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007654 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480007655 PLD-like domain; Region: PLDc_2; pfam13091 1032480007656 putative active site [active] 1032480007657 catalytic site [active] 1032480007658 PLD-like domain; Region: PLDc_2; pfam13091 1032480007659 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480007660 putative active site [active] 1032480007661 catalytic site [active] 1032480007662 Transglycosylase; Region: Transgly; pfam00912 1032480007663 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1032480007664 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1032480007665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480007666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480007667 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1032480007668 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1032480007669 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480007670 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480007671 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1032480007672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480007674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007675 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1032480007676 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1032480007677 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480007678 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480007679 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480007680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480007681 putative substrate translocation pore; other site 1032480007682 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480007683 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480007684 GAF domain; Region: GAF; cl17456 1032480007685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007686 DNA binding residues [nucleotide binding] 1032480007687 dimerization interface [polypeptide binding]; other site 1032480007688 Melibiase; Region: Melibiase; pfam02065 1032480007689 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1032480007690 active site 1032480007691 catalytic triad [active] 1032480007692 oxyanion hole [active] 1032480007693 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480007694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480007695 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480007696 DNA binding residues [nucleotide binding] 1032480007697 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1032480007698 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1032480007699 Flagellar FliJ protein; Region: FliJ; pfam02050 1032480007700 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1032480007701 MarR family; Region: MarR_2; cl17246 1032480007702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480007703 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480007704 active site 1032480007705 metal binding site [ion binding]; metal-binding site 1032480007706 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480007707 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1032480007708 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1032480007709 active site 1032480007710 ADP/pyrophosphate binding site [chemical binding]; other site 1032480007711 dimerization interface [polypeptide binding]; other site 1032480007712 allosteric effector site; other site 1032480007713 fructose-1,6-bisphosphate binding site; other site 1032480007714 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1032480007715 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1032480007716 aromatic arch; other site 1032480007717 DCoH dimer interaction site [polypeptide binding]; other site 1032480007718 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1032480007719 DCoH tetramer interaction site [polypeptide binding]; other site 1032480007720 substrate binding site [chemical binding]; other site 1032480007721 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1032480007722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007723 motif II; other site 1032480007724 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480007725 DinB superfamily; Region: DinB_2; pfam12867 1032480007726 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1032480007727 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480007728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480007729 active site 1032480007730 ATP binding site [chemical binding]; other site 1032480007731 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480007732 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1032480007733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480007734 Walker A/P-loop; other site 1032480007735 ATP binding site [chemical binding]; other site 1032480007736 Q-loop/lid; other site 1032480007737 ABC transporter signature motif; other site 1032480007738 Walker B; other site 1032480007739 D-loop; other site 1032480007740 H-loop/switch region; other site 1032480007741 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480007742 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1032480007743 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1032480007744 DNA binding residues [nucleotide binding] 1032480007745 drug binding residues [chemical binding]; other site 1032480007746 dimer interface [polypeptide binding]; other site 1032480007747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480007748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480007749 active site 1032480007750 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480007751 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1032480007752 active site 1032480007753 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1032480007754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007755 motif II; other site 1032480007756 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480007757 nudix motif; other site 1032480007758 HNH nucleases; Region: HNHc; smart00507 1032480007759 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1032480007760 active site 1032480007761 oxyanion hole [active] 1032480007762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480007763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480007764 DNA binding residues [nucleotide binding] 1032480007765 dimerization interface [polypeptide binding]; other site 1032480007766 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1032480007767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480007768 Walker A/P-loop; other site 1032480007769 ATP binding site [chemical binding]; other site 1032480007770 Q-loop/lid; other site 1032480007771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480007772 ABC transporter signature motif; other site 1032480007773 Walker B; other site 1032480007774 D-loop; other site 1032480007775 H-loop/switch region; other site 1032480007776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480007777 Walker A/P-loop; other site 1032480007778 ATP binding site [chemical binding]; other site 1032480007779 Q-loop/lid; other site 1032480007780 ABC transporter signature motif; other site 1032480007781 Walker B; other site 1032480007782 D-loop; other site 1032480007783 H-loop/switch region; other site 1032480007784 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480007785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480007786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007787 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480007788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480007789 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1032480007790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480007791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007792 active site 1032480007793 phosphorylation site [posttranslational modification] 1032480007794 intermolecular recognition site; other site 1032480007795 dimerization interface [polypeptide binding]; other site 1032480007796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480007797 DNA binding site [nucleotide binding] 1032480007798 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1032480007799 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1032480007800 active site 1032480007801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1032480007802 dimerization interface [polypeptide binding]; other site 1032480007803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480007804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480007805 dimer interface [polypeptide binding]; other site 1032480007806 phosphorylation site [posttranslational modification] 1032480007807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007808 ATP binding site [chemical binding]; other site 1032480007809 Mg2+ binding site [ion binding]; other site 1032480007810 G-X-G motif; other site 1032480007811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480007812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480007813 active site 1032480007814 phosphorylation site [posttranslational modification] 1032480007815 intermolecular recognition site; other site 1032480007816 dimerization interface [polypeptide binding]; other site 1032480007817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480007818 DNA binding site [nucleotide binding] 1032480007819 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1032480007820 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1032480007821 Ligand Binding Site [chemical binding]; other site 1032480007822 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1032480007823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480007824 dimer interface [polypeptide binding]; other site 1032480007825 phosphorylation site [posttranslational modification] 1032480007826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480007827 ATP binding site [chemical binding]; other site 1032480007828 Mg2+ binding site [ion binding]; other site 1032480007829 G-X-G motif; other site 1032480007830 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1032480007831 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1032480007832 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480007833 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1032480007834 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480007835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480007836 DNA binding residues [nucleotide binding] 1032480007837 dimer interface [polypeptide binding]; other site 1032480007838 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1032480007839 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480007840 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007841 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007842 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480007844 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480007845 DNA binding site [nucleotide binding] 1032480007846 domain linker motif; other site 1032480007847 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480007848 dimerization interface [polypeptide binding]; other site 1032480007849 ligand binding site [chemical binding]; other site 1032480007850 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480007851 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1032480007852 Metal-binding active site; metal-binding site 1032480007853 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480007854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480007855 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480007856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1032480007857 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1032480007858 Walker A/P-loop; other site 1032480007859 ATP binding site [chemical binding]; other site 1032480007860 Q-loop/lid; other site 1032480007861 ABC transporter signature motif; other site 1032480007862 Walker B; other site 1032480007863 D-loop; other site 1032480007864 H-loop/switch region; other site 1032480007865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1032480007866 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1032480007867 TM-ABC transporter signature motif; other site 1032480007868 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1032480007869 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1032480007870 putative ligand binding site [chemical binding]; other site 1032480007871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480007872 salt bridge; other site 1032480007873 non-specific DNA binding site [nucleotide binding]; other site 1032480007874 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480007875 sequence-specific DNA binding site [nucleotide binding]; other site 1032480007876 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1032480007877 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007878 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007879 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1032480007880 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1032480007881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480007882 Zn2+ binding site [ion binding]; other site 1032480007883 Mg2+ binding site [ion binding]; other site 1032480007884 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480007885 synthetase active site [active] 1032480007886 NTP binding site [chemical binding]; other site 1032480007887 metal binding site [ion binding]; metal-binding site 1032480007888 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1032480007889 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1032480007890 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1032480007891 TrkA-N domain; Region: TrkA_N; pfam02254 1032480007892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480007893 active site 1032480007894 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1032480007895 Protein export membrane protein; Region: SecD_SecF; pfam02355 1032480007896 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1032480007897 Protein export membrane protein; Region: SecD_SecF; cl14618 1032480007898 Preprotein translocase subunit; Region: YajC; pfam02699 1032480007899 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1032480007900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480007901 Walker A motif; other site 1032480007902 ATP binding site [chemical binding]; other site 1032480007903 Walker B motif; other site 1032480007904 arginine finger; other site 1032480007905 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1032480007906 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1032480007907 RuvA N terminal domain; Region: RuvA_N; pfam01330 1032480007908 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1032480007909 active site 1032480007910 putative DNA-binding cleft [nucleotide binding]; other site 1032480007911 dimer interface [polypeptide binding]; other site 1032480007912 hypothetical protein; Validated; Region: PRK00110 1032480007913 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480007914 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480007915 putative acyl-acceptor binding pocket; other site 1032480007916 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1032480007917 fatty acyl-CoA reductase; Region: PLN02996 1032480007918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480007919 NAD(P) binding site [chemical binding]; other site 1032480007920 active site 1032480007921 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 1032480007922 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1032480007923 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480007924 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1032480007925 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1032480007926 catalytic residues [active] 1032480007927 pseudaminic acid synthase; Region: PseI; TIGR03586 1032480007928 NeuB family; Region: NeuB; pfam03102 1032480007929 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1032480007930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480007931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480007932 DNA binding residues [nucleotide binding] 1032480007933 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1032480007934 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1032480007935 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480007936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480007937 motif II; other site 1032480007938 Protein of unknown function (DUF952); Region: DUF952; cl01393 1032480007939 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1032480007940 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1032480007941 putative active site [active] 1032480007942 oxyanion strand; other site 1032480007943 catalytic triad [active] 1032480007944 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1032480007945 putative active site pocket [active] 1032480007946 4-fold oligomerization interface [polypeptide binding]; other site 1032480007947 metal binding residues [ion binding]; metal-binding site 1032480007948 3-fold/trimer interface [polypeptide binding]; other site 1032480007949 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1032480007950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480007951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480007952 homodimer interface [polypeptide binding]; other site 1032480007953 catalytic residue [active] 1032480007954 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480007955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480007956 ATP binding site [chemical binding]; other site 1032480007957 putative Mg++ binding site [ion binding]; other site 1032480007958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480007959 nucleotide binding region [chemical binding]; other site 1032480007960 ATP-binding site [chemical binding]; other site 1032480007961 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1032480007962 PglZ domain; Region: PglZ; pfam08665 1032480007963 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1032480007964 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1032480007965 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480007966 Protein kinase domain; Region: Pkinase; pfam00069 1032480007967 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480007968 active site 1032480007969 ATP binding site [chemical binding]; other site 1032480007970 substrate binding site [chemical binding]; other site 1032480007971 activation loop (A-loop); other site 1032480007972 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1032480007973 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1032480007974 AzlC protein; Region: AzlC; cl00570 1032480007975 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1032480007976 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1032480007977 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1032480007978 putative deacylase active site [active] 1032480007979 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1032480007980 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1032480007981 active site 1032480007982 PHP Thumb interface [polypeptide binding]; other site 1032480007983 metal binding site [ion binding]; metal-binding site 1032480007984 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1032480007985 generic binding surface II; other site 1032480007986 generic binding surface I; other site 1032480007987 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480007988 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480007989 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 1032480007990 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480007991 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480007992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480007993 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480007994 DinB superfamily; Region: DinB_2; pfam12867 1032480007995 AAA domain; Region: AAA_33; pfam13671 1032480007996 AAA domain; Region: AAA_17; pfam13207 1032480007997 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480007998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480007999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008000 Walker A/P-loop; other site 1032480008001 ATP binding site [chemical binding]; other site 1032480008002 Q-loop/lid; other site 1032480008003 ABC transporter signature motif; other site 1032480008004 Walker B; other site 1032480008005 D-loop; other site 1032480008006 H-loop/switch region; other site 1032480008007 potential frameshift: common BLAST hit: gi|284033185|ref|YP_003383116.1| ABC transporter transmembrane protein 1032480008008 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1032480008009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008010 Q-loop/lid; other site 1032480008011 ABC transporter signature motif; other site 1032480008012 Walker B; other site 1032480008013 D-loop; other site 1032480008014 H-loop/switch region; other site 1032480008015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480008016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480008017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480008018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480008019 active site 1032480008020 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480008021 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1032480008022 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480008023 DinB superfamily; Region: DinB_2; pfam12867 1032480008024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480008025 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1032480008026 nucleophilic elbow; other site 1032480008027 catalytic triad; other site 1032480008028 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1032480008029 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1032480008030 catalytic triad [active] 1032480008031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480008032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008033 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1032480008034 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480008035 active site 1032480008036 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1032480008037 DNA binding site [nucleotide binding] 1032480008038 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1032480008039 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1032480008040 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1032480008041 NAD(P) binding site [chemical binding]; other site 1032480008042 catalytic residues [active] 1032480008043 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1032480008044 Beta-lactamase; Region: Beta-lactamase; cl17358 1032480008045 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480008046 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480008047 kynureninase; Region: kynureninase; TIGR01814 1032480008048 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480008049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480008050 catalytic residue [active] 1032480008051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480008052 active site 1032480008053 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1032480008054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008056 active site 1032480008057 phosphorylation site [posttranslational modification] 1032480008058 intermolecular recognition site; other site 1032480008059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008060 DNA binding residues [nucleotide binding] 1032480008061 dimerization interface [polypeptide binding]; other site 1032480008062 Histidine kinase; Region: HisKA_3; pfam07730 1032480008063 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480008064 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1032480008065 dimer interface [polypeptide binding]; other site 1032480008066 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480008067 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480008068 intersubunit interface [polypeptide binding]; other site 1032480008069 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1032480008070 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1032480008071 active site 1032480008072 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1032480008073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480008074 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1032480008075 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1032480008076 active site 1032480008077 dimer interface [polypeptide binding]; other site 1032480008078 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1032480008079 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1032480008080 active site 1032480008081 FMN binding site [chemical binding]; other site 1032480008082 substrate binding site [chemical binding]; other site 1032480008083 3Fe-4S cluster binding site [ion binding]; other site 1032480008084 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1032480008085 domain interface; other site 1032480008086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480008087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480008088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008089 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480008090 putative substrate translocation pore; other site 1032480008091 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1032480008092 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1032480008093 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1032480008094 shikimate binding site; other site 1032480008095 NAD(P) binding site [chemical binding]; other site 1032480008096 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480008097 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1032480008098 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480008099 PYR/PP interface [polypeptide binding]; other site 1032480008100 dimer interface [polypeptide binding]; other site 1032480008101 TPP binding site [chemical binding]; other site 1032480008102 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480008103 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480008104 TPP-binding site [chemical binding]; other site 1032480008105 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1032480008106 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1032480008107 active site 1032480008108 citrylCoA binding site [chemical binding]; other site 1032480008109 oxalacetate binding site [chemical binding]; other site 1032480008110 coenzyme A binding site [chemical binding]; other site 1032480008111 catalytic triad [active] 1032480008112 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1032480008113 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1032480008114 putative catalytic cysteine [active] 1032480008115 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1032480008116 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1032480008117 active site 1032480008118 trimer interface [polypeptide binding]; other site 1032480008119 dimer interface [polypeptide binding]; other site 1032480008120 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1032480008121 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1032480008122 ADP binding site [chemical binding]; other site 1032480008123 magnesium binding site [ion binding]; other site 1032480008124 putative shikimate binding site; other site 1032480008125 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1032480008126 active site 1032480008127 dimer interface [polypeptide binding]; other site 1032480008128 metal binding site [ion binding]; metal-binding site 1032480008129 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1032480008130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008131 NAD(P) binding site [chemical binding]; other site 1032480008132 active site 1032480008133 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1032480008134 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1032480008135 substrate binding site [chemical binding]; other site 1032480008136 active site 1032480008137 catalytic residues [active] 1032480008138 heterodimer interface [polypeptide binding]; other site 1032480008139 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1032480008140 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1032480008141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480008142 catalytic residue [active] 1032480008143 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1032480008144 active site 1032480008145 ribulose/triose binding site [chemical binding]; other site 1032480008146 phosphate binding site [ion binding]; other site 1032480008147 substrate (anthranilate) binding pocket [chemical binding]; other site 1032480008148 product (indole) binding pocket [chemical binding]; other site 1032480008149 anthranilate synthase component I; Provisional; Region: PRK13571 1032480008150 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1032480008151 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1032480008152 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1032480008153 TIGR03085 family protein; Region: TIGR03085 1032480008154 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1032480008155 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1032480008156 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1032480008157 Walker A/P-loop; other site 1032480008158 ATP binding site [chemical binding]; other site 1032480008159 Q-loop/lid; other site 1032480008160 ABC transporter signature motif; other site 1032480008161 Walker B; other site 1032480008162 D-loop; other site 1032480008163 H-loop/switch region; other site 1032480008164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480008165 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1032480008166 dimer interface [polypeptide binding]; other site 1032480008167 active site 1032480008168 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480008169 AMP binding site [chemical binding]; other site 1032480008170 active site 1032480008171 acyl-activating enzyme (AAE) consensus motif; other site 1032480008172 CoA binding site [chemical binding]; other site 1032480008173 potential frameshift: common BLAST hit: gi|310640441|ref|YP_003945199.1| glycoside hydrolase, family 3 1032480008174 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1032480008175 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480008176 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1032480008177 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1032480008178 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480008179 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480008180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480008181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480008182 BioY family; Region: BioY; pfam02632 1032480008183 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480008184 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480008185 intersubunit interface [polypeptide binding]; other site 1032480008186 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1032480008187 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1032480008188 GatB domain; Region: GatB_Yqey; smart00845 1032480008189 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1032480008190 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1032480008191 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1032480008192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480008193 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1032480008194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008195 Walker A/P-loop; other site 1032480008196 ATP binding site [chemical binding]; other site 1032480008197 Q-loop/lid; other site 1032480008198 ABC transporter signature motif; other site 1032480008199 Walker B; other site 1032480008200 D-loop; other site 1032480008201 H-loop/switch region; other site 1032480008202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480008203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008204 ABC transporter signature motif; other site 1032480008205 Walker B; other site 1032480008206 D-loop; other site 1032480008207 H-loop/switch region; other site 1032480008208 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1032480008209 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1032480008210 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008211 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1032480008212 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1032480008213 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1032480008214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008215 Walker A/P-loop; other site 1032480008216 ATP binding site [chemical binding]; other site 1032480008217 Q-loop/lid; other site 1032480008218 ABC transporter signature motif; other site 1032480008219 Walker B; other site 1032480008220 D-loop; other site 1032480008221 H-loop/switch region; other site 1032480008222 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1032480008223 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1032480008224 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1032480008225 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1032480008226 nucleotide binding pocket [chemical binding]; other site 1032480008227 K-X-D-G motif; other site 1032480008228 catalytic site [active] 1032480008229 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1032480008230 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1032480008231 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1032480008232 Dimer interface [polypeptide binding]; other site 1032480008233 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1032480008234 nucleoside/Zn binding site; other site 1032480008235 dimer interface [polypeptide binding]; other site 1032480008236 catalytic motif [active] 1032480008237 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480008238 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480008239 major facilitator superfamily transporter; Provisional; Region: PRK05122 1032480008240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480008241 putative substrate translocation pore; other site 1032480008242 Domain of unknown function DUF77; Region: DUF77; pfam01910 1032480008243 UDP-glucose 4-epimerase; Region: PLN02240 1032480008244 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1032480008245 NAD binding site [chemical binding]; other site 1032480008246 homodimer interface [polypeptide binding]; other site 1032480008247 active site 1032480008248 substrate binding site [chemical binding]; other site 1032480008249 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1032480008250 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1032480008251 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1032480008252 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1032480008253 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1032480008254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480008255 catalytic residue [active] 1032480008256 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1032480008257 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1032480008258 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1032480008259 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1032480008260 active site 1032480008261 catalytic site [active] 1032480008262 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1032480008263 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480008264 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1032480008265 active site 1032480008266 homodimer interface [polypeptide binding]; other site 1032480008267 catalytic site [active] 1032480008268 acceptor binding site [chemical binding]; other site 1032480008269 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1032480008270 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480008271 glycogen branching enzyme; Provisional; Region: PRK12313 1032480008272 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1032480008273 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1032480008274 active site 1032480008275 catalytic site [active] 1032480008276 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1032480008277 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480008278 nudix motif; other site 1032480008279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480008280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008281 ATP binding site [chemical binding]; other site 1032480008282 Mg2+ binding site [ion binding]; other site 1032480008283 G-X-G motif; other site 1032480008284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008286 active site 1032480008287 phosphorylation site [posttranslational modification] 1032480008288 intermolecular recognition site; other site 1032480008289 dimerization interface [polypeptide binding]; other site 1032480008290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008291 DNA binding residues [nucleotide binding] 1032480008292 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1032480008293 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480008294 active site 1032480008295 substrate binding site [chemical binding]; other site 1032480008296 trimer interface [polypeptide binding]; other site 1032480008297 CoA binding site [chemical binding]; other site 1032480008298 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1032480008299 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480008300 NAD binding site [chemical binding]; other site 1032480008301 hypothetical protein; Provisional; Region: PRK02237 1032480008302 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1032480008303 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480008304 phosphoglucomutase; Validated; Region: PRK07564 1032480008305 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1032480008306 active site 1032480008307 substrate binding site [chemical binding]; other site 1032480008308 metal binding site [ion binding]; metal-binding site 1032480008309 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1032480008310 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1032480008311 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 1032480008312 Fibronectin type 3 domain; Region: FN3; smart00060 1032480008313 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1032480008314 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1032480008315 ligand binding site; other site 1032480008316 tetramer interface; other site 1032480008317 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480008318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480008319 MarR family; Region: MarR; pfam01047 1032480008320 Bacterial PH domain; Region: DUF304; pfam03703 1032480008321 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1032480008322 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1032480008323 Walker A; other site 1032480008324 putative acyltransferase; Provisional; Region: PRK05790 1032480008325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480008326 dimer interface [polypeptide binding]; other site 1032480008327 active site 1032480008328 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1032480008329 DivIVA protein; Region: DivIVA; pfam05103 1032480008330 hypothetical protein; Provisional; Region: PRK03298 1032480008331 PGAP1-like protein; Region: PGAP1; pfam07819 1032480008332 acyl-CoA esterase; Provisional; Region: PRK10673 1032480008333 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1032480008334 active site 1032480008335 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1032480008336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480008337 Transposase; Region: HTH_Tnp_1; cl17663 1032480008338 putative transposase OrfB; Reviewed; Region: PHA02517 1032480008339 HTH-like domain; Region: HTH_21; pfam13276 1032480008340 Integrase core domain; Region: rve; pfam00665 1032480008341 Integrase core domain; Region: rve_3; pfam13683 1032480008342 potential protein location (hypothetical protein) that overlaps protein ( transposase orfB for insertion sequence element) 1032480008343 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480008344 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1032480008345 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1032480008346 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1032480008347 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1032480008348 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1032480008349 gamma subunit interface [polypeptide binding]; other site 1032480008350 epsilon subunit interface [polypeptide binding]; other site 1032480008351 LBP interface [polypeptide binding]; other site 1032480008352 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1032480008353 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1032480008354 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1032480008355 alpha subunit interaction interface [polypeptide binding]; other site 1032480008356 Walker A motif; other site 1032480008357 ATP binding site [chemical binding]; other site 1032480008358 Walker B motif; other site 1032480008359 inhibitor binding site; inhibition site 1032480008360 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1032480008361 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1032480008362 core domain interface [polypeptide binding]; other site 1032480008363 delta subunit interface [polypeptide binding]; other site 1032480008364 epsilon subunit interface [polypeptide binding]; other site 1032480008365 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1032480008366 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1032480008367 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1032480008368 beta subunit interaction interface [polypeptide binding]; other site 1032480008369 Walker A motif; other site 1032480008370 ATP binding site [chemical binding]; other site 1032480008371 Walker B motif; other site 1032480008372 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1032480008373 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1032480008374 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1032480008375 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1032480008376 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1032480008377 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1032480008378 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1032480008379 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1032480008380 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1032480008381 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1032480008382 Mg++ binding site [ion binding]; other site 1032480008383 putative catalytic motif [active] 1032480008384 substrate binding site [chemical binding]; other site 1032480008385 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1032480008386 UGMP family protein; Validated; Region: PRK09604 1032480008387 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1032480008388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480008389 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1032480008390 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1032480008391 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1032480008392 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1032480008393 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1032480008394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008395 S-adenosylmethionine binding site [chemical binding]; other site 1032480008396 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1032480008397 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1032480008398 RF-1 domain; Region: RF-1; pfam00472 1032480008399 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1032480008400 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1032480008401 transcription termination factor Rho; Provisional; Region: PRK12608 1032480008402 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480008403 RNA binding site [nucleotide binding]; other site 1032480008404 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1032480008405 Walker A motif; other site 1032480008406 ATP binding site [chemical binding]; other site 1032480008407 Walker B motif; other site 1032480008408 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1032480008409 threonine synthase; Reviewed; Region: PRK06721 1032480008410 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1032480008411 homodimer interface [polypeptide binding]; other site 1032480008412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480008413 catalytic residue [active] 1032480008414 homoserine dehydrogenase; Provisional; Region: PRK06349 1032480008415 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1032480008416 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1032480008417 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1032480008418 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1032480008419 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1032480008420 active site 1032480008421 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480008422 substrate binding site [chemical binding]; other site 1032480008423 catalytic residues [active] 1032480008424 dimer interface [polypeptide binding]; other site 1032480008425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480008426 non-specific DNA binding site [nucleotide binding]; other site 1032480008427 salt bridge; other site 1032480008428 sequence-specific DNA binding site [nucleotide binding]; other site 1032480008429 Phage capsid family; Region: Phage_capsid; pfam05065 1032480008430 Transcription factor WhiB; Region: Whib; pfam02467 1032480008431 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1032480008432 Helix-turn-helix domain; Region: HTH_17; cl17695 1032480008433 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1032480008434 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1032480008435 active site 1032480008436 catalytic residues [active] 1032480008437 DNA binding site [nucleotide binding] 1032480008438 Int/Topo IB signature motif; other site 1032480008439 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1032480008440 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480008441 putative active site [active] 1032480008442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480008443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008444 dimer interface [polypeptide binding]; other site 1032480008445 conserved gate region; other site 1032480008446 putative PBP binding loops; other site 1032480008447 ABC-ATPase subunit interface; other site 1032480008448 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008450 dimer interface [polypeptide binding]; other site 1032480008451 conserved gate region; other site 1032480008452 putative PBP binding loops; other site 1032480008453 ABC-ATPase subunit interface; other site 1032480008454 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1032480008455 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480008456 AAA domain; Region: AAA_14; pfam13173 1032480008457 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480008458 Ferritin-like; Region: Ferritin-like; pfam12902 1032480008459 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1032480008460 potential frameshift: common BLAST hit: gi|256824788|ref|YP_003148748.1| dimethyladenosine transferase (rRNA methylation) 1032480008461 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1032480008462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008463 S-adenosylmethionine binding site [chemical binding]; other site 1032480008464 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1032480008465 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1032480008466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1032480008467 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1032480008468 TPP-binding site [chemical binding]; other site 1032480008469 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1032480008470 dimer interface [polypeptide binding]; other site 1032480008471 PYR/PP interface [polypeptide binding]; other site 1032480008472 TPP binding site [chemical binding]; other site 1032480008473 potential protein location (hypothetical protein) that overlaps protein (2-oxoglutarate dehydrogenase E1 component) 1032480008474 Hemerythrin-like domain; Region: Hr-like; cd12108 1032480008475 Fe binding site [ion binding]; other site 1032480008476 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480008477 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480008478 NAD(P) binding site [chemical binding]; other site 1032480008479 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1032480008480 mevalonate kinase; Region: mevalon_kin; TIGR00549 1032480008481 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1032480008482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480008483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480008484 substrate binding pocket [chemical binding]; other site 1032480008485 membrane-bound complex binding site; other site 1032480008486 hinge residues; other site 1032480008487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1032480008489 dimer interface [polypeptide binding]; other site 1032480008490 conserved gate region; other site 1032480008491 putative PBP binding loops; other site 1032480008492 ABC-ATPase subunit interface; other site 1032480008493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1032480008494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1032480008495 Walker A/P-loop; other site 1032480008496 ATP binding site [chemical binding]; other site 1032480008497 Q-loop/lid; other site 1032480008498 ABC transporter signature motif; other site 1032480008499 Walker B; other site 1032480008500 D-loop; other site 1032480008501 H-loop/switch region; other site 1032480008502 Transcription factor WhiB; Region: Whib; pfam02467 1032480008503 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1032480008504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1032480008505 Histidine kinase; Region: HisKA_2; pfam07568 1032480008506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008507 ATP binding site [chemical binding]; other site 1032480008508 Mg2+ binding site [ion binding]; other site 1032480008509 G-X-G motif; other site 1032480008510 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1032480008511 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1032480008512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480008513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480008514 DNA binding residues [nucleotide binding] 1032480008515 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1032480008516 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1032480008517 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480008518 MarR family; Region: MarR_2; cl17246 1032480008519 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1032480008520 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1032480008521 hinge; other site 1032480008522 active site 1032480008523 Predicted GTPases [General function prediction only]; Region: COG1162 1032480008524 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480008525 RNA binding site [nucleotide binding]; other site 1032480008526 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1032480008527 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1032480008528 GTP/Mg2+ binding site [chemical binding]; other site 1032480008529 G4 box; other site 1032480008530 G1 box; other site 1032480008531 Switch I region; other site 1032480008532 G2 box; other site 1032480008533 G3 box; other site 1032480008534 Switch II region; other site 1032480008535 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1032480008536 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1032480008537 active site 1032480008538 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1032480008539 putative hydrophobic ligand binding site [chemical binding]; other site 1032480008540 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480008541 nudix motif; other site 1032480008542 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1032480008543 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1032480008544 ligand binding site [chemical binding]; other site 1032480008545 NAD binding site [chemical binding]; other site 1032480008546 tetramer interface [polypeptide binding]; other site 1032480008547 catalytic site [active] 1032480008548 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1032480008549 L-serine binding site [chemical binding]; other site 1032480008550 ACT domain interface; other site 1032480008551 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1032480008552 putative active site pocket [active] 1032480008553 cleavage site 1032480008554 Stage II sporulation protein; Region: SpoIID; pfam08486 1032480008555 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1032480008556 FG-GAP repeat; Region: FG-GAP; pfam01839 1032480008557 Family description; Region: VCBS; pfam13517 1032480008558 Family description; Region: VCBS; pfam13517 1032480008559 Family description; Region: VCBS; pfam13517 1032480008560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480008561 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480008562 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480008563 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480008564 conserved cys residue [active] 1032480008565 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1032480008566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480008567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480008568 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1032480008569 Walker A/P-loop; other site 1032480008570 ATP binding site [chemical binding]; other site 1032480008571 Q-loop/lid; other site 1032480008572 ABC transporter signature motif; other site 1032480008573 Walker B; other site 1032480008574 D-loop; other site 1032480008575 H-loop/switch region; other site 1032480008576 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480008577 PIN domain; Region: PIN_3; pfam13470 1032480008578 Phage-related protein [Function unknown]; Region: COG5412 1032480008579 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1032480008580 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1032480008581 active site 1032480008582 substrate binding site [chemical binding]; other site 1032480008583 trimer interface [polypeptide binding]; other site 1032480008584 CoA binding site [chemical binding]; other site 1032480008585 UreD urease accessory protein; Region: UreD; cl00530 1032480008586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1032480008587 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1032480008588 UreF; Region: UreF; pfam01730 1032480008589 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1032480008590 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1032480008591 subunit interactions [polypeptide binding]; other site 1032480008592 active site 1032480008593 flap region; other site 1032480008594 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1032480008595 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1032480008596 alpha-gamma subunit interface [polypeptide binding]; other site 1032480008597 beta-gamma subunit interface [polypeptide binding]; other site 1032480008598 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 1032480008599 alpha-beta subunit interface [polypeptide binding]; other site 1032480008600 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1032480008601 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1032480008602 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1032480008603 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1032480008604 Lamin Tail Domain; Region: LTD; pfam00932 1032480008605 Predicted peptidase [General function prediction only]; Region: COG4099 1032480008606 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1032480008607 short chain dehydrogenase; Provisional; Region: PRK06114 1032480008608 classical (c) SDRs; Region: SDR_c; cd05233 1032480008609 NAD(P) binding site [chemical binding]; other site 1032480008610 active site 1032480008611 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480008612 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1032480008613 molybdopterin cofactor binding site; other site 1032480008614 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1032480008615 molybdopterin cofactor binding site; other site 1032480008616 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 1032480008617 substrate binding site [chemical binding]; other site 1032480008618 Protein of unknown function (DUF521); Region: DUF521; pfam04412 1032480008619 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 1032480008620 substrate binding site [chemical binding]; other site 1032480008621 ligand binding site [chemical binding]; other site 1032480008622 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480008623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480008624 DNA-binding site [nucleotide binding]; DNA binding site 1032480008625 UTRA domain; Region: UTRA; pfam07702 1032480008626 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1032480008627 FMN binding site [chemical binding]; other site 1032480008628 substrate binding site [chemical binding]; other site 1032480008629 putative catalytic residue [active] 1032480008630 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1032480008631 putative active site [active] 1032480008632 putative metal binding residues [ion binding]; other site 1032480008633 signature motif; other site 1032480008634 putative dimer interface [polypeptide binding]; other site 1032480008635 putative phosphate binding site [ion binding]; other site 1032480008636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008637 Ligand Binding Site [chemical binding]; other site 1032480008638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1032480008639 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1032480008640 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1032480008641 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1032480008642 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1032480008643 calcium binding site 2 [ion binding]; other site 1032480008644 active site 1032480008645 catalytic triad [active] 1032480008646 calcium binding site 1 [ion binding]; other site 1032480008647 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480008648 Interdomain contacts; other site 1032480008649 Cytokine receptor motif; other site 1032480008650 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480008651 Interdomain contacts; other site 1032480008652 Cytokine receptor motif; other site 1032480008653 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1032480008654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480008655 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480008656 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1032480008657 active site residue [active] 1032480008658 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1032480008659 putative homotetramer interface [polypeptide binding]; other site 1032480008660 putative homodimer interface [polypeptide binding]; other site 1032480008661 putative allosteric switch controlling residues; other site 1032480008662 putative metal binding site [ion binding]; other site 1032480008663 putative homodimer-homodimer interface [polypeptide binding]; other site 1032480008664 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1032480008665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480008666 putative DNA binding site [nucleotide binding]; other site 1032480008667 putative Zn2+ binding site [ion binding]; other site 1032480008668 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480008669 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1032480008670 active site 1032480008671 SUMO-1 interface [polypeptide binding]; other site 1032480008672 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1032480008673 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480008674 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1032480008675 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480008676 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1032480008677 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1032480008678 hypothetical protein; Validated; Region: PRK00068 1032480008679 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1032480008680 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1032480008681 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480008682 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1032480008683 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1032480008684 MoaE homodimer interface [polypeptide binding]; other site 1032480008685 MoaD interaction [polypeptide binding]; other site 1032480008686 active site residues [active] 1032480008687 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1032480008688 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1032480008689 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1032480008690 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1032480008691 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1032480008692 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480008693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480008694 NAD(P) binding site [chemical binding]; other site 1032480008695 active site 1032480008696 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1032480008697 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1032480008698 DNA binding residues [nucleotide binding] 1032480008699 dimer interface [polypeptide binding]; other site 1032480008700 [2Fe-2S] cluster binding site [ion binding]; other site 1032480008701 Protein of unknown function DUF45; Region: DUF45; cl00636 1032480008702 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1032480008703 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1032480008704 ABC1 family; Region: ABC1; pfam03109 1032480008705 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480008706 active site 1032480008707 ATP binding site [chemical binding]; other site 1032480008708 Transcription factor WhiB; Region: Whib; pfam02467 1032480008709 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1032480008710 Part of AAA domain; Region: AAA_19; pfam13245 1032480008711 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008712 Family description; Region: UvrD_C_2; pfam13538 1032480008713 HRDC domain; Region: HRDC; pfam00570 1032480008714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480008715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480008716 Coenzyme A binding pocket [chemical binding]; other site 1032480008717 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1032480008718 catalytic residues [active] 1032480008719 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1032480008720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480008721 motif II; other site 1032480008722 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1032480008723 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480008724 oligomer interface [polypeptide binding]; other site 1032480008725 active site residues [active] 1032480008726 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1032480008727 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480008728 oligomer interface [polypeptide binding]; other site 1032480008729 active site residues [active] 1032480008730 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480008731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480008732 non-specific DNA binding site [nucleotide binding]; other site 1032480008733 salt bridge; other site 1032480008734 sequence-specific DNA binding site [nucleotide binding]; other site 1032480008735 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480008736 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1032480008737 DXD motif; other site 1032480008738 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1032480008739 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1032480008740 NodB motif; other site 1032480008741 active site 1032480008742 catalytic site [active] 1032480008743 metal binding site [ion binding]; metal-binding site 1032480008744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1032480008745 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1032480008746 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1032480008747 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1032480008748 glutaminase active site [active] 1032480008749 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480008750 dimer interface [polypeptide binding]; other site 1032480008751 active site 1032480008752 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480008753 dimer interface [polypeptide binding]; other site 1032480008754 active site 1032480008755 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1032480008756 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1032480008757 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1032480008758 Family description; Region: UvrD_C_2; pfam13538 1032480008759 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1032480008760 AAA domain; Region: AAA_30; pfam13604 1032480008761 Family description; Region: UvrD_C_2; pfam13538 1032480008762 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480008763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480008764 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480008765 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1032480008766 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1032480008767 putative active site [active] 1032480008768 putative metal binding site [ion binding]; other site 1032480008769 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1032480008770 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1032480008771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480008772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480008773 DNA binding site [nucleotide binding] 1032480008774 domain linker motif; other site 1032480008775 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480008776 ligand binding site [chemical binding]; other site 1032480008777 dimerization interface [polypeptide binding]; other site 1032480008778 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1032480008779 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1032480008780 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1032480008781 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1032480008782 putative NADH binding site [chemical binding]; other site 1032480008783 putative active site [active] 1032480008784 nudix motif; other site 1032480008785 putative metal binding site [ion binding]; other site 1032480008786 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008787 Part of AAA domain; Region: AAA_19; pfam13245 1032480008788 Family description; Region: UvrD_C_2; pfam13538 1032480008789 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1032480008790 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1032480008791 Family description; Region: UvrD_C_2; pfam13538 1032480008792 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1032480008793 PQQ-like domain; Region: PQQ_2; pfam13360 1032480008794 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1032480008795 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480008796 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1032480008797 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480008798 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1032480008799 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1032480008800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480008801 motif II; other site 1032480008802 Pirin-related protein [General function prediction only]; Region: COG1741 1032480008803 Pirin; Region: Pirin; pfam02678 1032480008804 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1032480008805 DNA binding site [nucleotide binding] 1032480008806 active site 1032480008807 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1032480008808 DNA-binding site [nucleotide binding]; DNA binding site 1032480008809 RNA-binding motif; other site 1032480008810 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1032480008811 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1032480008812 ATP binding site [chemical binding]; other site 1032480008813 substrate interface [chemical binding]; other site 1032480008814 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1032480008815 active site residue [active] 1032480008816 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1032480008817 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1032480008818 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1032480008819 dimer interface [polypeptide binding]; other site 1032480008820 putative anticodon binding site; other site 1032480008821 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1032480008822 motif 1; other site 1032480008823 dimer interface [polypeptide binding]; other site 1032480008824 active site 1032480008825 motif 2; other site 1032480008826 motif 3; other site 1032480008827 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1032480008828 nucleotide binding site [chemical binding]; other site 1032480008829 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008830 Ligand Binding Site [chemical binding]; other site 1032480008831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480008832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480008833 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1032480008834 Amidinotransferase; Region: Amidinotransf; cl12043 1032480008835 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008836 Ligand Binding Site [chemical binding]; other site 1032480008837 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480008838 Ligand Binding Site [chemical binding]; other site 1032480008839 amino acid transporter; Region: 2A0306; TIGR00909 1032480008840 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1032480008841 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1032480008842 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1032480008843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480008844 Walker A motif; other site 1032480008845 ATP binding site [chemical binding]; other site 1032480008846 Walker B motif; other site 1032480008847 arginine finger; other site 1032480008848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480008849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1032480008850 substrate binding pocket [chemical binding]; other site 1032480008851 membrane-bound complex binding site; other site 1032480008852 hinge residues; other site 1032480008853 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480008854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480008855 active site 1032480008856 ATP binding site [chemical binding]; other site 1032480008857 substrate binding site [chemical binding]; other site 1032480008858 activation loop (A-loop); other site 1032480008859 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1032480008860 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1032480008861 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480008862 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480008863 tartrate dehydrogenase; Region: TTC; TIGR02089 1032480008864 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1032480008865 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1032480008866 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1032480008867 PYR/PP interface [polypeptide binding]; other site 1032480008868 dimer interface [polypeptide binding]; other site 1032480008869 TPP binding site [chemical binding]; other site 1032480008870 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1032480008871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1032480008872 transketolase; Reviewed; Region: PRK05899 1032480008873 TPP-binding site [chemical binding]; other site 1032480008874 dimer interface [polypeptide binding]; other site 1032480008875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1032480008876 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480008877 DNA binding site [nucleotide binding] 1032480008878 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1032480008879 OsmC-like protein; Region: OsmC; cl00767 1032480008880 META domain; Region: META; pfam03724 1032480008881 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1032480008882 Predicted membrane protein [Function unknown]; Region: COG1511 1032480008883 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1032480008884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480008885 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1032480008886 Walker A/P-loop; other site 1032480008887 ATP binding site [chemical binding]; other site 1032480008888 Q-loop/lid; other site 1032480008889 ABC transporter signature motif; other site 1032480008890 Walker B; other site 1032480008891 D-loop; other site 1032480008892 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1032480008893 metal ion-dependent adhesion site (MIDAS); other site 1032480008894 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1032480008895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480008896 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480008897 phosphopeptide binding site; other site 1032480008898 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1032480008899 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1032480008900 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1032480008901 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1032480008902 ATP binding site [chemical binding]; other site 1032480008903 Mg++ binding site [ion binding]; other site 1032480008904 motif III; other site 1032480008905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480008906 nucleotide binding region [chemical binding]; other site 1032480008907 ATP-binding site [chemical binding]; other site 1032480008908 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1032480008909 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480008910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480008911 P-loop; other site 1032480008912 Magnesium ion binding site [ion binding]; other site 1032480008913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480008914 Magnesium ion binding site [ion binding]; other site 1032480008915 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1032480008916 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1032480008917 active site 1032480008918 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1032480008919 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1032480008920 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1032480008921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480008922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480008923 ATP binding site [chemical binding]; other site 1032480008924 Mg2+ binding site [ion binding]; other site 1032480008925 G-X-G motif; other site 1032480008926 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480008927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480008928 active site 1032480008929 phosphorylation site [posttranslational modification] 1032480008930 intermolecular recognition site; other site 1032480008931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480008932 DNA binding residues [nucleotide binding] 1032480008933 Family description; Region: VCBS; pfam13517 1032480008934 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1032480008935 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1032480008936 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1032480008937 putative DNA binding site [nucleotide binding]; other site 1032480008938 putative homodimer interface [polypeptide binding]; other site 1032480008939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480008940 S-adenosylmethionine binding site [chemical binding]; other site 1032480008941 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1032480008942 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1032480008943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480008944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480008945 DNA-binding site [nucleotide binding]; DNA binding site 1032480008946 UTRA domain; Region: UTRA; pfam07702 1032480008947 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1032480008948 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1032480008949 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1032480008950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1032480008951 nucleotide binding region [chemical binding]; other site 1032480008952 SEC-C motif; Region: SEC-C; pfam02810 1032480008953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1032480008954 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480008955 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1032480008956 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480008957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480008958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480008959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008960 ABC-ATPase subunit interface; other site 1032480008961 putative PBP binding loops; other site 1032480008962 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480008963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480008964 dimer interface [polypeptide binding]; other site 1032480008965 conserved gate region; other site 1032480008966 putative PBP binding loops; other site 1032480008967 ABC-ATPase subunit interface; other site 1032480008968 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1032480008969 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480008970 Walker A/P-loop; other site 1032480008971 ATP binding site [chemical binding]; other site 1032480008972 Q-loop/lid; other site 1032480008973 ABC transporter signature motif; other site 1032480008974 Walker B; other site 1032480008975 D-loop; other site 1032480008976 H-loop/switch region; other site 1032480008977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480008978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480008979 Walker A/P-loop; other site 1032480008980 ATP binding site [chemical binding]; other site 1032480008981 Q-loop/lid; other site 1032480008982 ABC transporter signature motif; other site 1032480008983 Walker B; other site 1032480008984 D-loop; other site 1032480008985 H-loop/switch region; other site 1032480008986 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1032480008987 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1032480008988 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480008989 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1032480008990 TetR family transcriptional regulator; Provisional; Region: PRK14996 1032480008991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480008992 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1032480008993 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1032480008994 30S subunit binding site; other site 1032480008995 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1032480008996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480008997 active site 1032480008998 lipoprotein LpqB; Provisional; Region: PRK13615 1032480008999 Sporulation and spore germination; Region: Germane; pfam10646 1032480009000 HAMP domain; Region: HAMP; pfam00672 1032480009001 dimerization interface [polypeptide binding]; other site 1032480009002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1032480009003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480009004 dimer interface [polypeptide binding]; other site 1032480009005 phosphorylation site [posttranslational modification] 1032480009006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009007 ATP binding site [chemical binding]; other site 1032480009008 Mg2+ binding site [ion binding]; other site 1032480009009 G-X-G motif; other site 1032480009010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480009011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009012 active site 1032480009013 phosphorylation site [posttranslational modification] 1032480009014 intermolecular recognition site; other site 1032480009015 dimerization interface [polypeptide binding]; other site 1032480009016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480009017 DNA binding site [nucleotide binding] 1032480009018 hypothetical protein; Validated; Region: PRK00228 1032480009019 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480009020 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1032480009021 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1032480009022 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1032480009023 putative NAD(P) binding site [chemical binding]; other site 1032480009024 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1032480009025 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1032480009026 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480009027 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480009028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480009029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009031 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1032480009032 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009033 metal ion-dependent adhesion site (MIDAS); other site 1032480009034 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480009035 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1032480009036 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1032480009037 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1032480009038 dimer interface [polypeptide binding]; other site 1032480009039 TPP-binding site [chemical binding]; other site 1032480009040 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1032480009041 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480009042 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480009043 active site 1032480009044 ATP binding site [chemical binding]; other site 1032480009045 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480009046 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1032480009047 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1032480009048 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1032480009049 NAD(P) binding pocket [chemical binding]; other site 1032480009050 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1032480009051 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1032480009052 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1032480009053 dihydropteroate synthase; Region: DHPS; TIGR01496 1032480009054 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1032480009055 substrate binding pocket [chemical binding]; other site 1032480009056 dimer interface [polypeptide binding]; other site 1032480009057 inhibitor binding site; inhibition site 1032480009058 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1032480009059 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1032480009060 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480009061 glutamate dehydrogenase; Provisional; Region: PRK09414 1032480009062 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1032480009063 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1032480009064 NAD(P) binding site [chemical binding]; other site 1032480009065 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1032480009066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009067 S-adenosylmethionine binding site [chemical binding]; other site 1032480009068 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1032480009069 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1032480009070 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1032480009071 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1032480009072 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480009073 Tic20-like protein; Region: Tic20; pfam09685 1032480009074 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1032480009075 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1032480009076 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1032480009077 SmpB-tmRNA interface; other site 1032480009078 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480009079 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480009080 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1032480009081 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1032480009082 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1032480009083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009084 Walker A/P-loop; other site 1032480009085 ATP binding site [chemical binding]; other site 1032480009086 Q-loop/lid; other site 1032480009087 ABC transporter signature motif; other site 1032480009088 Walker B; other site 1032480009089 D-loop; other site 1032480009090 H-loop/switch region; other site 1032480009091 DNA binding site [nucleotide binding] 1032480009092 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1032480009093 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480009094 TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity; Region: TFIIE_beta_winged_helix; cl02153 1032480009095 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480009096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009097 S-adenosylmethionine binding site [chemical binding]; other site 1032480009098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480009100 NAD(P) binding site [chemical binding]; other site 1032480009101 active site 1032480009102 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009104 DNA binding residues [nucleotide binding] 1032480009105 dimerization interface [polypeptide binding]; other site 1032480009106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480009107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480009108 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1032480009109 hypothetical protein; Provisional; Region: PRK07236 1032480009110 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1032480009111 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1032480009112 RF-1 domain; Region: RF-1; pfam00472 1032480009113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009114 Walker A/P-loop; other site 1032480009115 ATP binding site [chemical binding]; other site 1032480009116 ABC transporter; Region: ABC_tran; pfam00005 1032480009117 Q-loop/lid; other site 1032480009118 ABC transporter signature motif; other site 1032480009119 Walker B; other site 1032480009120 D-loop; other site 1032480009121 H-loop/switch region; other site 1032480009122 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480009123 Family description; Region: UvrD_C_2; pfam13538 1032480009124 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1032480009125 RibD C-terminal domain; Region: RibD_C; cl17279 1032480009126 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1032480009127 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1032480009128 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1032480009129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480009130 non-specific DNA binding site [nucleotide binding]; other site 1032480009131 salt bridge; other site 1032480009132 sequence-specific DNA binding site [nucleotide binding]; other site 1032480009133 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480009134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009135 Walker A motif; other site 1032480009136 ATP binding site [chemical binding]; other site 1032480009137 Walker B motif; other site 1032480009138 Integrase core domain; Region: rve; pfam00665 1032480009139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480009140 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1032480009141 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1032480009142 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1032480009143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480009144 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1032480009145 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1032480009146 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1032480009147 active site 1032480009148 hypothetical protein; Provisional; Region: PRK07945 1032480009149 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480009150 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1032480009151 active site 1032480009152 Pirin-related protein [General function prediction only]; Region: COG1741 1032480009153 Pirin; Region: Pirin; pfam02678 1032480009154 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1032480009155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009156 dimerization interface [polypeptide binding]; other site 1032480009157 putative DNA binding site [nucleotide binding]; other site 1032480009158 putative Zn2+ binding site [ion binding]; other site 1032480009159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480009160 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480009161 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480009162 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1032480009163 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1032480009164 acyl carrier protein; Provisional; Region: acpP; PRK00982 1032480009165 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1032480009166 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1032480009167 dimer interface [polypeptide binding]; other site 1032480009168 active site 1032480009169 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1032480009170 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1032480009171 putative active site [active] 1032480009172 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1032480009173 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480009174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1032480009175 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480009176 catalytic residue [active] 1032480009177 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1032480009178 metal ion-dependent adhesion site (MIDAS); other site 1032480009179 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1032480009180 metal ion-dependent adhesion site (MIDAS); other site 1032480009181 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480009182 Protein of unknown function DUF58; Region: DUF58; pfam01882 1032480009183 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480009184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009185 Walker A motif; other site 1032480009186 ATP binding site [chemical binding]; other site 1032480009187 Walker B motif; other site 1032480009188 arginine finger; other site 1032480009189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480009190 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1032480009191 active site 1032480009192 motif I; other site 1032480009193 motif II; other site 1032480009194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480009195 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1032480009196 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1032480009197 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480009198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009199 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480009200 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1032480009201 Pyruvate formate lyase 1; Region: PFL1; cd01678 1032480009202 coenzyme A binding site [chemical binding]; other site 1032480009203 active site 1032480009204 catalytic residues [active] 1032480009205 glycine loop; other site 1032480009206 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1032480009207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480009208 FeS/SAM binding site; other site 1032480009209 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480009210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480009211 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1032480009212 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1032480009213 active site 1032480009214 putative substrate binding pocket [chemical binding]; other site 1032480009215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480009216 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1032480009217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1032480009218 dimer interface [polypeptide binding]; other site 1032480009219 active site 1032480009220 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1032480009221 substrate binding site [chemical binding]; other site 1032480009222 catalytic residue [active] 1032480009223 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480009224 homotrimer interaction site [polypeptide binding]; other site 1032480009225 putative active site [active] 1032480009226 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1032480009227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009228 ATP binding site [chemical binding]; other site 1032480009229 Mg2+ binding site [ion binding]; other site 1032480009230 G-X-G motif; other site 1032480009231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009233 active site 1032480009234 dimerization interface [polypeptide binding]; other site 1032480009235 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1032480009236 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1032480009237 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1032480009238 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1032480009239 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1032480009240 active site 1032480009241 homotetramer interface [polypeptide binding]; other site 1032480009242 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1032480009243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480009244 DNA primase; Validated; Region: dnaG; PRK05667 1032480009245 CHC2 zinc finger; Region: zf-CHC2; cl17510 1032480009246 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1032480009247 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1032480009248 active site 1032480009249 metal binding site [ion binding]; metal-binding site 1032480009250 interdomain interaction site; other site 1032480009251 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1032480009252 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 1032480009253 Melibiase; Region: Melibiase; pfam02065 1032480009254 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009256 dimer interface [polypeptide binding]; other site 1032480009257 conserved gate region; other site 1032480009258 putative PBP binding loops; other site 1032480009259 ABC-ATPase subunit interface; other site 1032480009260 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1032480009261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009262 dimer interface [polypeptide binding]; other site 1032480009263 conserved gate region; other site 1032480009264 putative PBP binding loops; other site 1032480009265 ABC-ATPase subunit interface; other site 1032480009266 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480009267 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480009268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480009269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480009270 DNA binding site [nucleotide binding] 1032480009271 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480009272 dimerization interface [polypeptide binding]; other site 1032480009273 ligand binding site [chemical binding]; other site 1032480009274 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1032480009275 dimer interface [polypeptide binding]; other site 1032480009276 putative radical transfer pathway; other site 1032480009277 diiron center [ion binding]; other site 1032480009278 tyrosyl radical; other site 1032480009279 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1032480009280 ATP cone domain; Region: ATP-cone; pfam03477 1032480009281 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1032480009282 active site 1032480009283 dimer interface [polypeptide binding]; other site 1032480009284 catalytic residues [active] 1032480009285 effector binding site; other site 1032480009286 R2 peptide binding site; other site 1032480009287 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480009288 active site 1032480009289 NTP binding site [chemical binding]; other site 1032480009290 metal binding triad [ion binding]; metal-binding site 1032480009291 antibiotic binding site [chemical binding]; other site 1032480009292 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 1032480009293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480009294 Zn2+ binding site [ion binding]; other site 1032480009295 Mg2+ binding site [ion binding]; other site 1032480009296 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1032480009297 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1032480009298 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1032480009299 FMN binding site [chemical binding]; other site 1032480009300 active site 1032480009301 catalytic residues [active] 1032480009302 substrate binding site [chemical binding]; other site 1032480009303 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1032480009304 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1032480009305 motif 1; other site 1032480009306 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1032480009307 active site 1032480009308 motif 2; other site 1032480009309 motif 3; other site 1032480009310 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1032480009311 anticodon binding site; other site 1032480009312 Phospholipid methyltransferase; Region: PEMT; pfam04191 1032480009313 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1032480009314 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1032480009315 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1032480009316 putative hydrophobic ligand binding site [chemical binding]; other site 1032480009317 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1032480009318 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1032480009319 active site 1032480009320 metal binding site [ion binding]; metal-binding site 1032480009321 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1032480009322 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1032480009323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009324 S-adenosylmethionine binding site [chemical binding]; other site 1032480009325 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1032480009326 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480009327 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480009328 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480009329 Berberine and berberine like; Region: BBE; pfam08031 1032480009330 AAA ATPase domain; Region: AAA_16; pfam13191 1032480009331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009333 DNA binding residues [nucleotide binding] 1032480009334 dimerization interface [polypeptide binding]; other site 1032480009335 YceI-like domain; Region: YceI; pfam04264 1032480009336 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1032480009337 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1032480009338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480009339 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480009340 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1032480009341 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1032480009342 metal binding site [ion binding]; metal-binding site 1032480009343 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1032480009344 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1032480009345 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1032480009346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480009347 ABC-ATPase subunit interface; other site 1032480009348 dimer interface [polypeptide binding]; other site 1032480009349 putative PBP binding regions; other site 1032480009350 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1032480009351 metal binding site 2 [ion binding]; metal-binding site 1032480009352 putative DNA binding helix; other site 1032480009353 metal binding site 1 [ion binding]; metal-binding site 1032480009354 dimer interface [polypeptide binding]; other site 1032480009355 structural Zn2+ binding site [ion binding]; other site 1032480009356 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1032480009357 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480009358 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1032480009359 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1032480009360 catalytic residue [active] 1032480009361 putative FPP diphosphate binding site; other site 1032480009362 putative FPP binding hydrophobic cleft; other site 1032480009363 dimer interface [polypeptide binding]; other site 1032480009364 putative IPP diphosphate binding site; other site 1032480009365 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1032480009366 Recombination protein O N terminal; Region: RecO_N; pfam11967 1032480009367 Recombination protein O C terminal; Region: RecO_C; pfam02565 1032480009368 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1032480009369 Zn binding site [ion binding]; other site 1032480009370 2-isopropylmalate synthase; Validated; Region: PRK03739 1032480009371 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1032480009372 active site 1032480009373 catalytic residues [active] 1032480009374 metal binding site [ion binding]; metal-binding site 1032480009375 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1032480009376 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1032480009377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009378 active site 1032480009379 phosphorylation site [posttranslational modification] 1032480009380 intermolecular recognition site; other site 1032480009381 dimerization interface [polypeptide binding]; other site 1032480009382 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1032480009383 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1032480009384 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1032480009385 ATP binding site [chemical binding]; other site 1032480009386 G-X-G motif; other site 1032480009387 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1032480009388 Citrate transporter; Region: CitMHS; pfam03600 1032480009389 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480009390 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1032480009391 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480009392 putative active site [active] 1032480009393 catalytic site [active] 1032480009394 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1032480009395 putative active site [active] 1032480009396 catalytic site [active] 1032480009397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1032480009398 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1032480009399 GTPase Era; Reviewed; Region: era; PRK00089 1032480009400 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1032480009401 G1 box; other site 1032480009402 GTP/Mg2+ binding site [chemical binding]; other site 1032480009403 Switch I region; other site 1032480009404 G2 box; other site 1032480009405 Switch II region; other site 1032480009406 G3 box; other site 1032480009407 G4 box; other site 1032480009408 G5 box; other site 1032480009409 KH domain; Region: KH_2; pfam07650 1032480009410 Domain of unknown function DUF21; Region: DUF21; pfam01595 1032480009411 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480009412 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1032480009413 Transporter associated domain; Region: CorC_HlyC; smart01091 1032480009414 metal-binding heat shock protein; Provisional; Region: PRK00016 1032480009415 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1032480009416 PhoH-like protein; Region: PhoH; pfam02562 1032480009417 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480009418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1032480009419 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480009420 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480009421 intersubunit interface [polypeptide binding]; other site 1032480009422 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1032480009423 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1032480009424 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1032480009425 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1032480009426 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480009427 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1032480009428 putative active site [active] 1032480009429 RNA methyltransferase, RsmE family; Region: TIGR00046 1032480009430 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1032480009431 chaperone protein DnaJ; Provisional; Region: PRK14278 1032480009432 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1032480009433 HSP70 interaction site [polypeptide binding]; other site 1032480009434 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1032480009435 Zn binding sites [ion binding]; other site 1032480009436 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1032480009437 dimer interface [polypeptide binding]; other site 1032480009438 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1032480009439 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1032480009440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480009441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480009442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480009443 DNA binding site [nucleotide binding] 1032480009444 domain linker motif; other site 1032480009445 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1032480009446 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1032480009447 potential frameshift: common BLAST hit: gi|297626938|ref|YP_003688701.1| peptidase 1032480009448 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480009449 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480009450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480009451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009453 active site 1032480009454 phosphorylation site [posttranslational modification] 1032480009455 intermolecular recognition site; other site 1032480009456 dimerization interface [polypeptide binding]; other site 1032480009457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009458 DNA binding residues [nucleotide binding] 1032480009459 dimerization interface [polypeptide binding]; other site 1032480009460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480009461 Histidine kinase; Region: HisKA_3; pfam07730 1032480009462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009463 ATP binding site [chemical binding]; other site 1032480009464 Mg2+ binding site [ion binding]; other site 1032480009465 G-X-G motif; other site 1032480009466 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1032480009467 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1032480009468 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1032480009469 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1032480009470 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480009471 synthetase active site [active] 1032480009472 NTP binding site [chemical binding]; other site 1032480009473 metal binding site [ion binding]; metal-binding site 1032480009474 CotH protein; Region: CotH; pfam08757 1032480009475 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480009476 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1032480009477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480009479 putative substrate translocation pore; other site 1032480009480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009481 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480009482 AAA domain; Region: AAA_18; pfam13238 1032480009483 active site 1032480009484 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480009485 HNH nucleases; Region: HNHc; smart00507 1032480009486 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1032480009487 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480009488 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1032480009489 putative NAD(P) binding site [chemical binding]; other site 1032480009490 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1032480009491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009492 putative substrate translocation pore; other site 1032480009493 POT family; Region: PTR2; cl17359 1032480009494 Putative methyltransferase; Region: Methyltransf_4; cl17290 1032480009495 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480009496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009497 S-adenosylmethionine binding site [chemical binding]; other site 1032480009498 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480009499 Predicted ATPase [General function prediction only]; Region: COG3903 1032480009500 GTP-binding protein LepA; Provisional; Region: PRK05433 1032480009501 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1032480009502 G1 box; other site 1032480009503 putative GEF interaction site [polypeptide binding]; other site 1032480009504 GTP/Mg2+ binding site [chemical binding]; other site 1032480009505 Switch I region; other site 1032480009506 G2 box; other site 1032480009507 G3 box; other site 1032480009508 Switch II region; other site 1032480009509 G4 box; other site 1032480009510 G5 box; other site 1032480009511 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1032480009512 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1032480009513 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1032480009514 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1032480009515 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1032480009516 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1032480009517 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1032480009518 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1032480009519 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480009520 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1032480009521 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1032480009522 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480009523 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480009524 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480009525 active site 1032480009526 ATP binding site [chemical binding]; other site 1032480009527 Competence protein; Region: Competence; pfam03772 1032480009528 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1032480009529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480009530 putative transposase OrfB; Reviewed; Region: PHA02517 1032480009531 HTH-like domain; Region: HTH_21; pfam13276 1032480009532 Integrase core domain; Region: rve; pfam00665 1032480009533 Integrase core domain; Region: rve_3; pfam13683 1032480009534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480009535 Transposase; Region: HTH_Tnp_1; cl17663 1032480009536 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1032480009537 Competence protein; Region: Competence; pfam03772 1032480009538 SLBB domain; Region: SLBB; pfam10531 1032480009539 comEA protein; Region: comE; TIGR01259 1032480009540 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480009541 EDD domain protein, DegV family; Region: DegV; TIGR00762 1032480009542 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1032480009543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480009544 Coenzyme A binding pocket [chemical binding]; other site 1032480009545 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480009546 putative catalytic site [active] 1032480009547 putative metal binding site [ion binding]; other site 1032480009548 putative phosphate binding site [ion binding]; other site 1032480009549 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480009550 catalytic core [active] 1032480009551 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1032480009552 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1032480009553 HIGH motif; other site 1032480009554 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1032480009555 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480009556 active site 1032480009557 KMSKS motif; other site 1032480009558 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1032480009559 tRNA binding surface [nucleotide binding]; other site 1032480009560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480009561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009562 putative substrate translocation pore; other site 1032480009563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480009565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480009566 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480009567 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480009568 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480009569 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480009570 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1032480009571 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480009572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480009573 catalytic residue [active] 1032480009574 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480009575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1032480009577 NAD(P) binding site [chemical binding]; other site 1032480009578 active site 1032480009579 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480009580 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1032480009581 nudix motif; other site 1032480009582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009583 dimerization interface [polypeptide binding]; other site 1032480009584 putative DNA binding site [nucleotide binding]; other site 1032480009585 putative Zn2+ binding site [ion binding]; other site 1032480009586 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1032480009587 putative hydrophobic ligand binding site [chemical binding]; other site 1032480009588 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1032480009589 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1032480009590 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1032480009591 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 1032480009592 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480009593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480009594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480009595 Zn2+ binding site [ion binding]; other site 1032480009596 Mg2+ binding site [ion binding]; other site 1032480009597 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1032480009598 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1032480009599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480009600 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1032480009601 putative substrate binding site [chemical binding]; other site 1032480009602 putative ATP binding site [chemical binding]; other site 1032480009603 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1032480009604 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1032480009605 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1032480009606 active site 1032480009607 catalytic residues [active] 1032480009608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480009609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480009610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480009611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480009612 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480009613 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480009614 Rhomboid family; Region: Rhomboid; pfam01694 1032480009615 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1032480009616 putative binding surface; other site 1032480009617 active site 1032480009618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009619 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480009620 active site 1032480009621 phosphorylation site [posttranslational modification] 1032480009622 intermolecular recognition site; other site 1032480009623 dimerization interface [polypeptide binding]; other site 1032480009624 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1032480009625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1032480009626 putative active site [active] 1032480009627 heme pocket [chemical binding]; other site 1032480009628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480009629 dimer interface [polypeptide binding]; other site 1032480009630 phosphorylation site [posttranslational modification] 1032480009631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009632 ATP binding site [chemical binding]; other site 1032480009633 Mg2+ binding site [ion binding]; other site 1032480009634 G-X-G motif; other site 1032480009635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480009636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009637 active site 1032480009638 phosphorylation site [posttranslational modification] 1032480009639 intermolecular recognition site; other site 1032480009640 dimerization interface [polypeptide binding]; other site 1032480009641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480009642 DNA binding site [nucleotide binding] 1032480009643 Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]; Region: SAC6; COG5069 1032480009644 benzoate transport; Region: 2A0115; TIGR00895 1032480009645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009646 putative substrate translocation pore; other site 1032480009647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009648 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480009649 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1032480009650 active site 1032480009651 catalytic residues [active] 1032480009652 TPR repeat; Region: TPR_11; pfam13414 1032480009653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480009654 binding surface 1032480009655 TPR motif; other site 1032480009656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480009657 CHAT domain; Region: CHAT; cl17868 1032480009658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480009659 Ligand Binding Site [chemical binding]; other site 1032480009660 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480009661 Ligand Binding Site [chemical binding]; other site 1032480009662 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1032480009663 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1032480009664 trimer interface [polypeptide binding]; other site 1032480009665 putative metal binding site [ion binding]; other site 1032480009666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480009667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480009668 active site 1032480009669 catalytic tetrad [active] 1032480009670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480009671 ATP binding site [chemical binding]; other site 1032480009672 putative Mg++ binding site [ion binding]; other site 1032480009673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480009674 nucleotide binding region [chemical binding]; other site 1032480009675 ATP-binding site [chemical binding]; other site 1032480009676 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480009677 PLD-like domain; Region: PLDc_2; pfam13091 1032480009678 putative active site [active] 1032480009679 catalytic site [active] 1032480009680 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1032480009681 PLD-like domain; Region: PLDc_2; pfam13091 1032480009682 putative active site [active] 1032480009683 catalytic site [active] 1032480009684 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1032480009685 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1032480009686 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1032480009687 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1032480009688 Cl- selectivity filter; other site 1032480009689 Cl- binding residues [ion binding]; other site 1032480009690 pore gating glutamate residue; other site 1032480009691 dimer interface [polypeptide binding]; other site 1032480009692 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1032480009693 Beta-lactamase; Region: Beta-lactamase; pfam00144 1032480009694 tyramine oxidase; Provisional; Region: tynA; PRK11504 1032480009695 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1032480009696 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1032480009697 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1032480009698 biotin carboxylase-like protein; Validated; Region: PRK06524 1032480009699 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480009700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1032480009701 binding surface 1032480009702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1032480009703 TPR motif; other site 1032480009704 succinic semialdehyde dehydrogenase; Region: PLN02278 1032480009705 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1032480009706 tetramerization interface [polypeptide binding]; other site 1032480009707 NAD(P) binding site [chemical binding]; other site 1032480009708 catalytic residues [active] 1032480009709 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1032480009710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480009711 inhibitor-cofactor binding pocket; inhibition site 1032480009712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480009713 catalytic residue [active] 1032480009714 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1032480009715 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480009716 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1032480009717 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480009718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480009719 catalytic residue [active] 1032480009720 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1032480009721 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1032480009722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480009723 Amidohydrolase; Region: Amidohydro_4; pfam13147 1032480009724 active site 1032480009725 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1032480009726 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1032480009727 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480009728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480009729 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480009730 active site 1032480009731 ATP binding site [chemical binding]; other site 1032480009732 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1032480009733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009734 ABC transporter signature motif; other site 1032480009735 Walker B; other site 1032480009736 D-loop; other site 1032480009737 H-loop/switch region; other site 1032480009738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009739 AAA domain; Region: AAA_21; pfam13304 1032480009740 Walker A/P-loop; other site 1032480009741 ATP binding site [chemical binding]; other site 1032480009742 Q-loop/lid; other site 1032480009743 ABC transporter signature motif; other site 1032480009744 Walker B; other site 1032480009745 D-loop; other site 1032480009746 H-loop/switch region; other site 1032480009747 Predicted flavoprotein [General function prediction only]; Region: COG0431 1032480009748 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1032480009749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480009750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480009751 dimerization interface [polypeptide binding]; other site 1032480009752 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1032480009753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480009754 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480009755 catalytic site [active] 1032480009756 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1032480009757 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1032480009758 iron-sulfur cluster [ion binding]; other site 1032480009759 [2Fe-2S] cluster binding site [ion binding]; other site 1032480009760 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1032480009761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480009762 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1032480009763 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1032480009764 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1032480009765 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1032480009766 [4Fe-4S] binding site [ion binding]; other site 1032480009767 molybdopterin cofactor binding site; other site 1032480009768 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1032480009769 molybdopterin cofactor binding site; other site 1032480009770 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1032480009771 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480009772 active site 1032480009773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1032480009774 DNA binding site [nucleotide binding] 1032480009775 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1032480009776 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1032480009777 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1032480009778 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1032480009779 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1032480009780 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480009781 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1032480009782 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1032480009783 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1032480009784 AAA ATPase domain; Region: AAA_16; pfam13191 1032480009785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009787 DNA binding residues [nucleotide binding] 1032480009788 dimerization interface [polypeptide binding]; other site 1032480009789 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480009790 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1032480009791 potential protein location (hypothetical protein) that overlaps protein (peptidase S1 family protein) 1032480009792 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480009793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480009794 Walker A motif; other site 1032480009795 ATP binding site [chemical binding]; other site 1032480009796 Walker B motif; other site 1032480009797 arginine finger; other site 1032480009798 Protein of unknown function DUF58; Region: DUF58; pfam01882 1032480009799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009800 metal ion-dependent adhesion site (MIDAS); other site 1032480009801 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1032480009802 metal ion-dependent adhesion site (MIDAS); other site 1032480009803 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1032480009804 metal ion-dependent adhesion site (MIDAS); other site 1032480009805 VanZ like family; Region: VanZ; pfam04892 1032480009806 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1032480009807 Predicted ATPase [General function prediction only]; Region: COG3899 1032480009808 AAA ATPase domain; Region: AAA_16; pfam13191 1032480009809 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480009810 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1032480009811 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480009812 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1032480009813 active site 1032480009814 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1032480009815 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1032480009816 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480009817 synthetase active site [active] 1032480009818 NTP binding site [chemical binding]; other site 1032480009819 metal binding site [ion binding]; metal-binding site 1032480009820 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480009821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480009822 Histidine kinase; Region: HisKA_3; pfam07730 1032480009823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480009824 ATP binding site [chemical binding]; other site 1032480009825 Mg2+ binding site [ion binding]; other site 1032480009826 G-X-G motif; other site 1032480009827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480009828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480009829 active site 1032480009830 phosphorylation site [posttranslational modification] 1032480009831 intermolecular recognition site; other site 1032480009832 dimerization interface [polypeptide binding]; other site 1032480009833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480009834 DNA binding residues [nucleotide binding] 1032480009835 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480009836 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1032480009837 Predicted ATPase [General function prediction only]; Region: COG3903 1032480009838 AAA domain; Region: AAA_14; pfam13173 1032480009839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480009840 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480009841 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480009842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480009843 S-adenosylmethionine binding site [chemical binding]; other site 1032480009844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1032480009845 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480009846 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480009847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480009848 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480009849 NAD(P) binding site [chemical binding]; other site 1032480009850 active site 1032480009851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480009852 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480009853 salt bridge; other site 1032480009854 non-specific DNA binding site [nucleotide binding]; other site 1032480009855 sequence-specific DNA binding site [nucleotide binding]; other site 1032480009856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480009857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480009858 putative DNA binding site [nucleotide binding]; other site 1032480009859 putative Zn2+ binding site [ion binding]; other site 1032480009860 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480009861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480009862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009863 Q-loop/lid; other site 1032480009864 ABC transporter signature motif; other site 1032480009865 Walker B; other site 1032480009866 D-loop; other site 1032480009867 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480009868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480009869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009870 Walker A/P-loop; other site 1032480009871 ATP binding site [chemical binding]; other site 1032480009872 Q-loop/lid; other site 1032480009873 ABC transporter signature motif; other site 1032480009874 Walker B; other site 1032480009875 D-loop; other site 1032480009876 H-loop/switch region; other site 1032480009877 Helix-turn-helix domain; Region: HTH_17; cl17695 1032480009878 PIN domain; Region: PIN_3; cl17397 1032480009879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480009880 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1032480009881 potential frameshift: common BLAST hit: gi|256391016|ref|YP_003112580.1| filamentation induced by cAMP protein Fic 1032480009882 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480009883 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009884 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480009885 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1032480009886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1032480009887 ATP binding site [chemical binding]; other site 1032480009888 putative Mg++ binding site [ion binding]; other site 1032480009889 Divergent AAA domain; Region: AAA_4; pfam04326 1032480009890 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480009891 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1032480009892 DNA methylase; Region: N6_N4_Mtase; pfam01555 1032480009893 DNA methylase; Region: N6_N4_Mtase; cl17433 1032480009894 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1032480009895 DNA methylase; Region: N6_N4_Mtase; pfam01555 1032480009896 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1032480009897 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 1032480009898 putative active site [active] 1032480009899 catalytic site [active] 1032480009900 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1032480009901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480009902 ATP binding site [chemical binding]; other site 1032480009903 putative Mg++ binding site [ion binding]; other site 1032480009904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480009905 nucleotide binding region [chemical binding]; other site 1032480009906 ATP-binding site [chemical binding]; other site 1032480009907 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1032480009908 Protein of unknown function DUF262; Region: DUF262; pfam03235 1032480009909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480009910 Transposase; Region: HTH_Tnp_1; cl17663 1032480009911 putative transposase OrfB; Reviewed; Region: PHA02517 1032480009912 HTH-like domain; Region: HTH_21; pfam13276 1032480009913 Integrase core domain; Region: rve; pfam00665 1032480009914 Integrase core domain; Region: rve_3; pfam13683 1032480009915 Protein of unknown function DUF262; Region: DUF262; pfam03235 1032480009916 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1032480009917 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 1032480009918 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480009919 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480009920 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480009921 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1032480009922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009923 AAA domain; Region: AAA_13; pfam13166 1032480009924 Walker A/P-loop; other site 1032480009925 ATP binding site [chemical binding]; other site 1032480009926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480009927 ABC transporter signature motif; other site 1032480009928 Walker B; other site 1032480009929 D-loop; other site 1032480009930 H-loop/switch region; other site 1032480009931 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1032480009932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480009933 putative substrate translocation pore; other site 1032480009934 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480009935 catalytic core [active] 1032480009936 Oligomerisation domain; Region: Oligomerisation; pfam02410 1032480009937 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1032480009938 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1032480009939 active site 1032480009940 (T/H)XGH motif; other site 1032480009941 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1032480009942 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1032480009943 putative catalytic cysteine [active] 1032480009944 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1032480009945 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480009946 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480009947 FAD binding pocket [chemical binding]; other site 1032480009948 FAD binding motif [chemical binding]; other site 1032480009949 phosphate binding motif [ion binding]; other site 1032480009950 NAD binding pocket [chemical binding]; other site 1032480009951 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1032480009952 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1032480009953 active site 1032480009954 DNA binding site [nucleotide binding] 1032480009955 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1032480009956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480009957 Walker A/P-loop; other site 1032480009958 ATP binding site [chemical binding]; other site 1032480009959 Q-loop/lid; other site 1032480009960 ABC transporter signature motif; other site 1032480009961 Walker B; other site 1032480009962 D-loop; other site 1032480009963 H-loop/switch region; other site 1032480009964 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1032480009965 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1032480009966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480009967 Walker A/P-loop; other site 1032480009968 ATP binding site [chemical binding]; other site 1032480009969 Q-loop/lid; other site 1032480009970 ABC transporter signature motif; other site 1032480009971 Walker B; other site 1032480009972 D-loop; other site 1032480009973 H-loop/switch region; other site 1032480009974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1032480009975 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1032480009976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009977 putative PBP binding loops; other site 1032480009978 dimer interface [polypeptide binding]; other site 1032480009979 ABC-ATPase subunit interface; other site 1032480009980 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480009981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480009982 dimer interface [polypeptide binding]; other site 1032480009983 conserved gate region; other site 1032480009984 putative PBP binding loops; other site 1032480009985 ABC-ATPase subunit interface; other site 1032480009986 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1032480009987 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1032480009988 peptide binding site [polypeptide binding]; other site 1032480009989 hypothetical protein; Provisional; Region: PRK06185 1032480009990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480009991 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480009992 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480009993 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480009994 homodimer interface [polypeptide binding]; other site 1032480009995 active site 1032480009996 TDP-binding site; other site 1032480009997 acceptor substrate-binding pocket; other site 1032480009998 gamma-glutamyl kinase; Provisional; Region: PRK05429 1032480009999 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1032480010000 nucleotide binding site [chemical binding]; other site 1032480010001 homotetrameric interface [polypeptide binding]; other site 1032480010002 putative phosphate binding site [ion binding]; other site 1032480010003 putative allosteric binding site; other site 1032480010004 PUA domain; Region: PUA; pfam01472 1032480010005 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1032480010006 GTP1/OBG; Region: GTP1_OBG; pfam01018 1032480010007 Obg GTPase; Region: Obg; cd01898 1032480010008 G1 box; other site 1032480010009 GTP/Mg2+ binding site [chemical binding]; other site 1032480010010 Switch I region; other site 1032480010011 G2 box; other site 1032480010012 G3 box; other site 1032480010013 Switch II region; other site 1032480010014 G4 box; other site 1032480010015 G5 box; other site 1032480010016 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1032480010017 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1032480010018 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1032480010019 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1032480010020 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1032480010021 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1032480010022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010023 dimerization interface [polypeptide binding]; other site 1032480010024 putative DNA binding site [nucleotide binding]; other site 1032480010025 putative Zn2+ binding site [ion binding]; other site 1032480010026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480010027 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480010028 active site 1032480010029 metal binding site [ion binding]; metal-binding site 1032480010030 ferredoxin-NADP+ reductase; Region: PLN02852 1032480010031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480010032 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1032480010033 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1032480010034 homodimer interface [polypeptide binding]; other site 1032480010035 oligonucleotide binding site [chemical binding]; other site 1032480010036 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1032480010037 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1032480010038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010039 dimerization interface [polypeptide binding]; other site 1032480010040 putative DNA binding site [nucleotide binding]; other site 1032480010041 putative Zn2+ binding site [ion binding]; other site 1032480010042 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1032480010043 putative hydrophobic ligand binding site [chemical binding]; other site 1032480010044 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480010045 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480010046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480010047 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480010048 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480010049 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1032480010050 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1032480010051 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1032480010052 B12 binding site [chemical binding]; other site 1032480010053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480010054 FeS/SAM binding site; other site 1032480010055 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1032480010056 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1032480010057 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1032480010058 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1032480010059 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1032480010060 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1032480010061 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1032480010062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1032480010063 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1032480010064 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1032480010065 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 1032480010066 active site 1032480010067 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1032480010068 Sulfatase; Region: Sulfatase; pfam00884 1032480010069 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1032480010070 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1032480010071 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1032480010072 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1032480010073 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1032480010074 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1032480010075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010076 potential frameshift: common BLAST hit: gi|284029290|ref|YP_003379221.1| periplasmic binding protein 1032480010077 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010078 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010079 intersubunit interface [polypeptide binding]; other site 1032480010080 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010081 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010082 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1032480010083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010084 NAD(P) binding site [chemical binding]; other site 1032480010085 active site 1032480010086 Transcriptional regulator; Region: Rrf2; pfam02082 1032480010087 Rrf2 family protein; Region: rrf2_super; TIGR00738 1032480010088 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1032480010089 cofactor binding site; other site 1032480010090 metal binding site [ion binding]; metal-binding site 1032480010091 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1032480010092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480010093 active site 1032480010094 HIGH motif; other site 1032480010095 nucleotide binding site [chemical binding]; other site 1032480010096 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480010097 active site 1032480010098 KMSKS motif; other site 1032480010099 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1032480010100 tRNA binding surface [nucleotide binding]; other site 1032480010101 anticodon binding site; other site 1032480010102 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1032480010103 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1032480010104 putative active site [active] 1032480010105 catalytic triad [active] 1032480010106 putative dimer interface [polypeptide binding]; other site 1032480010107 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480010108 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1032480010109 Thioredoxin; Region: Thioredoxin_4; pfam13462 1032480010110 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1032480010111 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1032480010112 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1032480010113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010114 Walker A motif; other site 1032480010115 ATP binding site [chemical binding]; other site 1032480010116 Walker B motif; other site 1032480010117 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1032480010118 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1032480010119 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480010120 oligomer interface [polypeptide binding]; other site 1032480010121 active site residues [active] 1032480010122 Clp protease; Region: CLP_protease; pfam00574 1032480010123 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1032480010124 oligomer interface [polypeptide binding]; other site 1032480010125 active site residues [active] 1032480010126 trigger factor; Provisional; Region: tig; PRK01490 1032480010127 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1032480010128 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1032480010129 PAS domain S-box; Region: sensory_box; TIGR00229 1032480010130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1032480010131 putative active site [active] 1032480010132 heme pocket [chemical binding]; other site 1032480010133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480010134 dimer interface [polypeptide binding]; other site 1032480010135 phosphorylation site [posttranslational modification] 1032480010136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480010137 ATP binding site [chemical binding]; other site 1032480010138 Mg2+ binding site [ion binding]; other site 1032480010139 G-X-G motif; other site 1032480010140 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1032480010141 Ferritin-like; Region: Ferritin-like; pfam12902 1032480010142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480010143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480010144 active site 1032480010145 catalytic tetrad [active] 1032480010146 Protein of unknown function (DUF917); Region: DUF917; cl17829 1032480010147 cyclase homology domain; Region: CHD; cd07302 1032480010148 nucleotidyl binding site; other site 1032480010149 metal binding site [ion binding]; metal-binding site 1032480010150 dimer interface [polypeptide binding]; other site 1032480010151 cyclase homology domain; Region: CHD; cd07302 1032480010152 dimer interface [polypeptide binding]; other site 1032480010153 nucleotidyl binding site; other site 1032480010154 metal binding site [ion binding]; metal-binding site 1032480010155 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1032480010156 AAA ATPase domain; Region: AAA_16; pfam13191 1032480010157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1032480010158 TPR motif; other site 1032480010159 binding surface 1032480010160 Ferritin-like; Region: Ferritin-like; pfam12902 1032480010161 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1032480010162 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1032480010163 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1032480010164 active site 1032480010165 catalytic site [active] 1032480010166 DNA polymerase IV; Provisional; Region: PRK03348 1032480010167 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1032480010168 active site 1032480010169 DNA binding site [nucleotide binding] 1032480010170 Peptidase C26; Region: Peptidase_C26; pfam07722 1032480010171 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1032480010172 catalytic triad [active] 1032480010173 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1032480010174 CAAX protease self-immunity; Region: Abi; pfam02517 1032480010175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480010176 Histidine kinase; Region: HisKA_3; pfam07730 1032480010177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010179 active site 1032480010180 phosphorylation site [posttranslational modification] 1032480010181 intermolecular recognition site; other site 1032480010182 dimerization interface [polypeptide binding]; other site 1032480010183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010184 DNA binding residues [nucleotide binding] 1032480010185 dimerization interface [polypeptide binding]; other site 1032480010186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480010187 active site 1032480010188 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480010189 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480010190 catalytic site [active] 1032480010191 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480010192 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1032480010193 putative DNA binding site [nucleotide binding]; other site 1032480010194 catalytic residue [active] 1032480010195 putative H2TH interface [polypeptide binding]; other site 1032480010196 putative catalytic residues [active] 1032480010197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480010198 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480010199 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1032480010200 putative active site [active] 1032480010201 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1032480010202 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1032480010203 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1032480010204 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1032480010205 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1032480010206 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480010207 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1032480010208 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1032480010209 Zn binding site [ion binding]; other site 1032480010210 Repair protein; Region: Repair_PSII; cl01535 1032480010211 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1032480010212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480010213 active site 1032480010214 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1032480010215 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1032480010216 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1032480010217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480010218 dihydroorotase; Validated; Region: pyrC; PRK09357 1032480010219 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1032480010220 active site 1032480010221 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1032480010222 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1032480010223 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1032480010224 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1032480010225 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1032480010226 active site 1032480010227 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1032480010228 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480010229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480010230 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480010231 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1032480010232 active site 1032480010233 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1032480010234 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1032480010235 apolar tunnel; other site 1032480010236 heme binding site [chemical binding]; other site 1032480010237 dimerization interface [polypeptide binding]; other site 1032480010238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480010240 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1032480010241 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480010242 NAD(P) binding site [chemical binding]; other site 1032480010243 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1032480010244 active site 1032480010245 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1032480010246 active site 1032480010247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010248 NAD(P) binding site [chemical binding]; other site 1032480010249 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1032480010250 active site 1032480010251 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1032480010252 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1032480010253 acyl-activating enzyme (AAE) consensus motif; other site 1032480010254 putative AMP binding site [chemical binding]; other site 1032480010255 putative active site [active] 1032480010256 putative CoA binding site [chemical binding]; other site 1032480010257 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1032480010258 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1032480010259 dimer interface [polypeptide binding]; other site 1032480010260 active site 1032480010261 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480010262 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480010263 active site 1032480010264 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1032480010265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480010266 MarR family; Region: MarR; pfam01047 1032480010267 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480010268 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480010269 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1032480010270 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1032480010271 FAD binding pocket [chemical binding]; other site 1032480010272 conserved FAD binding motif [chemical binding]; other site 1032480010273 phosphate binding motif [ion binding]; other site 1032480010274 beta-alpha-beta structure motif; other site 1032480010275 NAD binding pocket [chemical binding]; other site 1032480010276 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1032480010277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480010278 Walker A/P-loop; other site 1032480010279 ATP binding site [chemical binding]; other site 1032480010280 Q-loop/lid; other site 1032480010281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480010282 ABC transporter; Region: ABC_tran_2; pfam12848 1032480010283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480010284 FOG: CBS domain [General function prediction only]; Region: COG0517 1032480010285 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1032480010286 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1032480010287 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480010288 dimer interface [polypeptide binding]; other site 1032480010289 ssDNA binding site [nucleotide binding]; other site 1032480010290 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480010291 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1032480010292 G1 box; other site 1032480010293 GTP/Mg2+ binding site [chemical binding]; other site 1032480010294 G2 box; other site 1032480010295 Switch I region; other site 1032480010296 G3 box; other site 1032480010297 Switch II region; other site 1032480010298 G4 box; other site 1032480010299 G5 box; other site 1032480010300 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1032480010301 G1 box; other site 1032480010302 GTP/Mg2+ binding site [chemical binding]; other site 1032480010303 G2 box; other site 1032480010304 Switch I region; other site 1032480010305 G3 box; other site 1032480010306 Switch II region; other site 1032480010307 Protease prsW family; Region: PrsW-protease; pfam13367 1032480010308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480010309 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480010310 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1032480010311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480010312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010313 putative substrate translocation pore; other site 1032480010314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010315 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1032480010316 catalytic site [active] 1032480010317 putative active site [active] 1032480010318 putative substrate binding site [chemical binding]; other site 1032480010319 dimer interface [polypeptide binding]; other site 1032480010320 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1032480010321 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480010322 catalytic residues [active] 1032480010323 catalytic nucleophile [active] 1032480010324 Recombinase; Region: Recombinase; pfam07508 1032480010325 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1032480010326 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480010327 dimer interface [polypeptide binding]; other site 1032480010328 ssDNA binding site [nucleotide binding]; other site 1032480010329 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480010330 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1032480010331 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1032480010332 Walker A motif; other site 1032480010333 ATP binding site [chemical binding]; other site 1032480010334 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1032480010335 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1032480010336 active site 1032480010337 catalytic residues [active] 1032480010338 DNA binding site [nucleotide binding] 1032480010339 Int/Topo IB signature motif; other site 1032480010340 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1032480010341 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1032480010342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480010343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480010344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480010345 catalytic residues [active] 1032480010346 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480010347 arsenical-resistance protein; Region: acr3; TIGR00832 1032480010348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010349 putative DNA binding site [nucleotide binding]; other site 1032480010350 putative Zn2+ binding site [ion binding]; other site 1032480010351 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480010352 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1032480010353 active site 1032480010354 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480010355 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480010356 active site 1032480010357 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1032480010358 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480010359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010360 dimerization interface [polypeptide binding]; other site 1032480010361 putative DNA binding site [nucleotide binding]; other site 1032480010362 putative Zn2+ binding site [ion binding]; other site 1032480010363 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1032480010364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480010365 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1032480010366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480010367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010368 dimerization interface [polypeptide binding]; other site 1032480010369 putative DNA binding site [nucleotide binding]; other site 1032480010370 putative Zn2+ binding site [ion binding]; other site 1032480010371 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1032480010372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010373 Coenzyme A binding pocket [chemical binding]; other site 1032480010374 AAA-like domain; Region: AAA_10; pfam12846 1032480010375 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1032480010376 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1032480010377 CGNR zinc finger; Region: zf-CGNR; pfam11706 1032480010378 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480010379 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1032480010380 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1032480010381 metal binding sites [ion binding]; metal-binding site 1032480010382 Apx/Shroom domain ASD2; Region: ASD2; pfam08687 1032480010383 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480010384 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1032480010385 active site 1032480010386 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480010387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010388 S-adenosylmethionine binding site [chemical binding]; other site 1032480010389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010390 dimerization interface [polypeptide binding]; other site 1032480010391 putative DNA binding site [nucleotide binding]; other site 1032480010392 putative Zn2+ binding site [ion binding]; other site 1032480010393 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1032480010394 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1032480010395 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1032480010396 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1032480010397 active site 1032480010398 catalytic residues [active] 1032480010399 DNA binding site [nucleotide binding] 1032480010400 Int/Topo IB signature motif; other site 1032480010401 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1032480010402 Peptidase family M23; Region: Peptidase_M23; pfam01551 1032480010403 ParB-like nuclease domain; Region: ParB; smart00470 1032480010404 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1032480010405 Helix-turn-helix domain; Region: HTH_38; pfam13936 1032480010406 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1032480010407 polymerase nucleotide-binding site; other site 1032480010408 DNA-binding residues [nucleotide binding]; DNA binding site 1032480010409 nucleotide binding site [chemical binding]; other site 1032480010410 primase nucleotide-binding site [nucleotide binding]; other site 1032480010411 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1032480010412 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480010413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010414 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1032480010415 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1032480010416 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1032480010417 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1032480010418 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480010419 metal-binding site [ion binding] 1032480010420 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1032480010421 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480010422 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1032480010423 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1032480010424 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1032480010425 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1032480010426 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1032480010427 cofactor binding site; other site 1032480010428 DNA binding site [nucleotide binding] 1032480010429 substrate interaction site [chemical binding]; other site 1032480010430 TrwC relaxase; Region: TrwC; pfam08751 1032480010431 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1032480010432 AAA domain; Region: AAA_30; pfam13604 1032480010433 AAA domain; Region: AAA_22; pfam13401 1032480010434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010437 recombination factor protein RarA; Reviewed; Region: PRK13342 1032480010438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480010439 Walker A motif; other site 1032480010440 ATP binding site [chemical binding]; other site 1032480010441 Walker B motif; other site 1032480010442 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1032480010443 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1032480010444 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1032480010445 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1032480010446 homotrimer interaction site [polypeptide binding]; other site 1032480010447 putative active site [active] 1032480010448 Predicted transcriptional regulator [Transcription]; Region: COG2378 1032480010449 HTH domain; Region: HTH_11; pfam08279 1032480010450 WYL domain; Region: WYL; pfam13280 1032480010451 potential frameshift: common BLAST hit: gi|308176205|ref|YP_003915611.1| smf family protein 1032480010452 DNA protecting protein DprA; Region: dprA; TIGR00732 1032480010453 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1032480010454 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1032480010455 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1032480010456 DNA-binding interface [nucleotide binding]; DNA binding site 1032480010457 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480010458 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1032480010459 catalytic residues [active] 1032480010460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480010461 salt bridge; other site 1032480010462 non-specific DNA binding site [nucleotide binding]; other site 1032480010463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480010464 sequence-specific DNA binding site [nucleotide binding]; other site 1032480010465 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1032480010466 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1032480010467 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480010468 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480010469 PA14 domain; Region: PA14; cl08459 1032480010470 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480010471 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480010472 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480010473 NAD(P) binding site [chemical binding]; other site 1032480010474 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480010475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480010476 non-specific DNA binding site [nucleotide binding]; other site 1032480010477 salt bridge; other site 1032480010478 sequence-specific DNA binding site [nucleotide binding]; other site 1032480010479 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480010480 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1032480010481 putative NAD(P) binding site [chemical binding]; other site 1032480010482 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1032480010483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480010484 Walker A/P-loop; other site 1032480010485 ATP binding site [chemical binding]; other site 1032480010486 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1032480010487 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1032480010488 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1032480010489 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1032480010490 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480010491 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1032480010492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480010493 active site 1032480010494 DNA binding site [nucleotide binding] 1032480010495 Int/Topo IB signature motif; other site 1032480010496 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1032480010497 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1032480010498 Divergent AAA domain; Region: AAA_4; pfam04326 1032480010499 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1032480010500 TIGR02687 family protein; Region: TIGR02687 1032480010501 PglZ domain; Region: PglZ; pfam08665 1032480010502 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1032480010503 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 1032480010504 SIR2-like domain; Region: SIR2_2; pfam13289 1032480010505 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480010506 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480010507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480010508 Transposase; Region: HTH_Tnp_1; cl17663 1032480010509 putative transposase OrfB; Reviewed; Region: PHA02517 1032480010510 HTH-like domain; Region: HTH_21; pfam13276 1032480010511 Integrase core domain; Region: rve; pfam00665 1032480010512 Integrase core domain; Region: rve_3; pfam13683 1032480010513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480010514 Transposase; Region: HTH_Tnp_1; cl17663 1032480010515 putative transposase OrfB; Reviewed; Region: PHA02517 1032480010516 HTH-like domain; Region: HTH_21; pfam13276 1032480010517 Integrase core domain; Region: rve; pfam00665 1032480010518 Integrase core domain; Region: rve_3; pfam13683 1032480010519 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1032480010520 Domain of unknown function DUF87; Region: DUF87; pfam01935 1032480010521 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1032480010522 LabA_like proteins; Region: LabA_like; cd06167 1032480010523 putative metal binding site [ion binding]; other site 1032480010524 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480010525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480010526 DNA-binding site [nucleotide binding]; DNA binding site 1032480010527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480010528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480010529 homodimer interface [polypeptide binding]; other site 1032480010530 catalytic residue [active] 1032480010531 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1032480010532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480010533 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480010534 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480010535 NAD(P) binding site [chemical binding]; other site 1032480010536 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480010537 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480010538 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1032480010539 Cupin; Region: Cupin_6; pfam12852 1032480010540 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010542 short chain dehydrogenase; Validated; Region: PRK06182 1032480010543 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1032480010544 NADP binding site [chemical binding]; other site 1032480010545 active site 1032480010546 steroid binding site; other site 1032480010547 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480010548 NAD(P) binding site [chemical binding]; other site 1032480010549 catalytic residues [active] 1032480010550 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480010551 RibD C-terminal domain; Region: RibD_C; cl17279 1032480010552 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1032480010553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480010554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480010555 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1032480010556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010557 putative DNA binding site [nucleotide binding]; other site 1032480010558 putative Zn2+ binding site [ion binding]; other site 1032480010559 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480010560 putative hydrophobic ligand binding site [chemical binding]; other site 1032480010561 SnoaL-like domain; Region: SnoaL_2; pfam12680 1032480010562 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1032480010563 active site 1032480010564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480010566 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1032480010567 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1032480010568 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1032480010569 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1032480010570 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1032480010571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480010572 Walker A/P-loop; other site 1032480010573 ATP binding site [chemical binding]; other site 1032480010574 Q-loop/lid; other site 1032480010575 ABC transporter signature motif; other site 1032480010576 Walker B; other site 1032480010577 D-loop; other site 1032480010578 H-loop/switch region; other site 1032480010579 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1032480010580 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480010581 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1032480010582 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480010583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010584 putative substrate translocation pore; other site 1032480010585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480010586 Histidine kinase; Region: HisKA_3; pfam07730 1032480010587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480010588 ATP binding site [chemical binding]; other site 1032480010589 Mg2+ binding site [ion binding]; other site 1032480010590 G-X-G motif; other site 1032480010591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010593 active site 1032480010594 phosphorylation site [posttranslational modification] 1032480010595 intermolecular recognition site; other site 1032480010596 dimerization interface [polypeptide binding]; other site 1032480010597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010598 DNA binding residues [nucleotide binding] 1032480010599 dimerization interface [polypeptide binding]; other site 1032480010600 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1032480010601 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1032480010602 DAK2 domain; Region: Dak2; cl03685 1032480010603 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1032480010604 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1032480010605 regulatory phosphorylation site [posttranslational modification]; other site 1032480010606 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1032480010607 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1032480010608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480010609 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1032480010610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480010611 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1032480010612 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1032480010613 catalytic triad [active] 1032480010614 YhhN-like protein; Region: YhhN; pfam07947 1032480010615 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480010616 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480010617 active site 1032480010618 catalytic tetrad [active] 1032480010619 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1032480010620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480010621 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1032480010622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1032480010623 ATP binding site [chemical binding]; other site 1032480010624 putative Mg++ binding site [ion binding]; other site 1032480010625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480010626 nucleotide binding region [chemical binding]; other site 1032480010627 ATP-binding site [chemical binding]; other site 1032480010628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480010629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480010630 active site 1032480010631 catalytic tetrad [active] 1032480010632 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1032480010633 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1032480010634 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480010635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480010636 dimer interface [polypeptide binding]; other site 1032480010637 conserved gate region; other site 1032480010638 ABC-ATPase subunit interface; other site 1032480010639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480010640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1032480010641 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1032480010642 oligomerisation interface [polypeptide binding]; other site 1032480010643 mobile loop; other site 1032480010644 roof hairpin; other site 1032480010645 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1032480010646 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480010647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480010648 putative DNA binding site [nucleotide binding]; other site 1032480010649 putative Zn2+ binding site [ion binding]; other site 1032480010650 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1032480010651 catalytic triad [active] 1032480010652 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1032480010653 amphipathic channel; other site 1032480010654 Asn-Pro-Ala signature motifs; other site 1032480010655 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1032480010656 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1032480010657 folate binding site [chemical binding]; other site 1032480010658 NADP+ binding site [chemical binding]; other site 1032480010659 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1032480010660 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1032480010661 dimerization interface [polypeptide binding]; other site 1032480010662 active site 1032480010663 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1032480010664 active site 1032480010665 dimerization interface [polypeptide binding]; other site 1032480010666 ribonuclease PH; Reviewed; Region: rph; PRK00173 1032480010667 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1032480010668 hexamer interface [polypeptide binding]; other site 1032480010669 active site 1032480010670 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1032480010671 glutamate racemase; Provisional; Region: PRK00865 1032480010672 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480010673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480010674 DNA-binding site [nucleotide binding]; DNA binding site 1032480010675 UTRA domain; Region: UTRA; cl17743 1032480010676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010677 putative substrate translocation pore; other site 1032480010678 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1032480010679 active site 1032480010680 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480010681 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1032480010682 substrate binding site [chemical binding]; other site 1032480010683 dimer interface [polypeptide binding]; other site 1032480010684 ATP binding site [chemical binding]; other site 1032480010685 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1032480010686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1032480010687 TIGR03086 family protein; Region: TIGR03086 1032480010688 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1032480010689 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1032480010690 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1032480010691 dimer interface [polypeptide binding]; other site 1032480010692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480010693 catalytic residue [active] 1032480010694 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1032480010695 MoaE interaction surface [polypeptide binding]; other site 1032480010696 MoeB interaction surface [polypeptide binding]; other site 1032480010697 thiocarboxylated glycine; other site 1032480010698 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1032480010699 MPN+ (JAMM) motif; other site 1032480010700 Zinc-binding site [ion binding]; other site 1032480010701 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1032480010702 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1032480010703 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480010704 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480010705 active site 1032480010706 metal binding site [ion binding]; metal-binding site 1032480010707 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1032480010708 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1032480010709 active site 1032480010710 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1032480010711 Isochorismatase family; Region: Isochorismatase; pfam00857 1032480010712 catalytic triad [active] 1032480010713 metal binding site [ion binding]; metal-binding site 1032480010714 conserved cis-peptide bond; other site 1032480010715 short chain dehydrogenase; Provisional; Region: PRK06197 1032480010716 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1032480010717 putative NAD(P) binding site [chemical binding]; other site 1032480010718 active site 1032480010719 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 1032480010720 active site 1032480010721 catalytic triad [active] 1032480010722 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1032480010723 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1032480010724 fumarylacetoacetase; Region: PLN02856 1032480010725 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1032480010726 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1032480010727 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480010728 RDD family; Region: RDD; pfam06271 1032480010729 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1032480010730 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1032480010731 dimer interface [polypeptide binding]; other site 1032480010732 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1032480010733 active site 1032480010734 Fe binding site [ion binding]; other site 1032480010735 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480010736 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1032480010737 putative DNA binding site [nucleotide binding]; other site 1032480010738 putative Zn2+ binding site [ion binding]; other site 1032480010739 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480010740 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480010741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480010742 active site 1032480010743 ATP binding site [chemical binding]; other site 1032480010744 substrate binding site [chemical binding]; other site 1032480010745 activation loop (A-loop); other site 1032480010746 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480010747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480010748 ATP binding site [chemical binding]; other site 1032480010749 putative Mg++ binding site [ion binding]; other site 1032480010750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480010752 putative substrate translocation pore; other site 1032480010753 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1032480010754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480010755 catalytic core [active] 1032480010756 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480010757 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480010758 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1032480010759 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480010760 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1032480010761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1032480010762 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1032480010763 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1032480010764 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1032480010765 homotetramer interface [polypeptide binding]; other site 1032480010766 ligand binding site [chemical binding]; other site 1032480010767 catalytic site [active] 1032480010768 NAD binding site [chemical binding]; other site 1032480010769 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1032480010770 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480010771 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1032480010772 EamA-like transporter family; Region: EamA; cl17759 1032480010773 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1032480010774 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480010775 Cation efflux family; Region: Cation_efflux; pfam01545 1032480010776 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480010777 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1032480010778 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1032480010779 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1032480010780 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1032480010781 active site 1032480010782 substrate binding site [chemical binding]; other site 1032480010783 metal binding site [ion binding]; metal-binding site 1032480010784 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1032480010785 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1032480010786 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1032480010787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480010788 active site 1032480010789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480010790 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1032480010791 Transcription factor WhiB; Region: Whib; pfam02467 1032480010792 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1032480010793 phosphate binding site [ion binding]; other site 1032480010794 dimer interface [polypeptide binding]; other site 1032480010795 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1032480010796 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1032480010797 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1032480010798 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1032480010799 Substrate binding site; other site 1032480010800 TIGR03089 family protein; Region: TIGR03089 1032480010801 Protein of unknown function (DUF402); Region: DUF402; cl00979 1032480010802 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1032480010803 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1032480010804 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1032480010805 tetrameric interface [polypeptide binding]; other site 1032480010806 NAD binding site [chemical binding]; other site 1032480010807 catalytic residues [active] 1032480010808 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480010809 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1032480010810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480010811 PYR/PP interface [polypeptide binding]; other site 1032480010812 dimer interface [polypeptide binding]; other site 1032480010813 TPP binding site [chemical binding]; other site 1032480010814 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480010815 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1032480010816 TPP-binding site; other site 1032480010817 KduI/IolB family; Region: KduI; pfam04962 1032480010818 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1032480010819 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480010820 substrate binding site [chemical binding]; other site 1032480010821 ATP binding site [chemical binding]; other site 1032480010822 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1032480010823 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1032480010824 Ligand binding site; other site 1032480010825 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1032480010826 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1032480010827 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1032480010828 Predicted ATPase [General function prediction only]; Region: COG3910 1032480010829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480010830 Walker A/P-loop; other site 1032480010831 ATP binding site [chemical binding]; other site 1032480010832 Q-loop/lid; other site 1032480010833 ABC transporter signature motif; other site 1032480010834 Walker B; other site 1032480010835 D-loop; other site 1032480010836 H-loop/switch region; other site 1032480010837 Arginase family; Region: Arginase; pfam00491 1032480010838 agmatinase; Region: agmatinase; TIGR01230 1032480010839 active site 1032480010840 metal binding site [ion binding]; metal-binding site 1032480010841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480010842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480010843 active site 1032480010844 ferredoxin-NADP+ reductase; Region: PLN02852 1032480010845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480010846 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1032480010847 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1032480010848 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 1032480010849 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480010850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010851 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480010852 putative substrate translocation pore; other site 1032480010853 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480010854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480010855 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480010856 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1032480010857 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1032480010858 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480010859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480010860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480010861 DNA binding site [nucleotide binding] 1032480010862 domain linker motif; other site 1032480010863 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480010864 dimerization interface [polypeptide binding]; other site 1032480010865 ligand binding site [chemical binding]; other site 1032480010866 Isochorismatase family; Region: Isochorismatase; pfam00857 1032480010867 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1032480010868 catalytic triad [active] 1032480010869 conserved cis-peptide bond; other site 1032480010870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480010871 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1032480010872 LssY C-terminus; Region: LssY_C; pfam14067 1032480010873 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480010874 active site 1032480010875 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1032480010876 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1032480010877 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1032480010878 Moco binding site; other site 1032480010879 metal coordination site [ion binding]; other site 1032480010880 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1032480010881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480010882 Histidine kinase; Region: HisKA_3; pfam07730 1032480010883 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480010884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480010885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480010886 active site 1032480010887 phosphorylation site [posttranslational modification] 1032480010888 intermolecular recognition site; other site 1032480010889 dimerization interface [polypeptide binding]; other site 1032480010890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480010891 DNA binding residues [nucleotide binding] 1032480010892 dimerization interface [polypeptide binding]; other site 1032480010893 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480010894 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480010895 Walker A/P-loop; other site 1032480010896 ATP binding site [chemical binding]; other site 1032480010897 Q-loop/lid; other site 1032480010898 ABC transporter signature motif; other site 1032480010899 Walker B; other site 1032480010900 D-loop; other site 1032480010901 H-loop/switch region; other site 1032480010902 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480010903 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480010904 FtsX-like permease family; Region: FtsX; pfam02687 1032480010905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480010906 Ligand Binding Site [chemical binding]; other site 1032480010907 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1032480010908 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1032480010909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010910 putative substrate translocation pore; other site 1032480010911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480010912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480010913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010914 Coenzyme A binding pocket [chemical binding]; other site 1032480010915 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1032480010916 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1032480010917 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1032480010918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480010919 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 1032480010920 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480010921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480010922 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480010923 NAD(P) binding site [chemical binding]; other site 1032480010924 active site 1032480010925 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1032480010926 Cupin; Region: Cupin_6; pfam12852 1032480010927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480010929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480010930 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480010931 active site 1032480010932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010933 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010934 intersubunit interface [polypeptide binding]; other site 1032480010935 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480010936 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480010937 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480010938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010939 S-adenosylmethionine binding site [chemical binding]; other site 1032480010940 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1032480010941 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480010943 active site 1032480010944 ATP binding site [chemical binding]; other site 1032480010945 substrate binding site [chemical binding]; other site 1032480010946 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480010947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010948 S-adenosylmethionine binding site [chemical binding]; other site 1032480010949 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480010950 AAA domain; Region: AAA_33; pfam13671 1032480010951 active site 1032480010952 potential frameshift: common BLAST hit: gi|291301756|ref|YP_003513034.1| methyltransferase type 11 1032480010953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480010954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480010955 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1032480010956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480010957 active site 1032480010958 ATP binding site [chemical binding]; other site 1032480010959 PemK-like protein; Region: PemK; pfam02452 1032480010960 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480010961 conserved cys residue [active] 1032480010962 Cupin domain; Region: Cupin_2; cl17218 1032480010963 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480010964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480010966 L-idonate 5-dehydrogenase; Region: PLN02702 1032480010967 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1032480010968 inhibitor binding site; inhibition site 1032480010969 catalytic Zn binding site [ion binding]; other site 1032480010970 structural Zn binding site [ion binding]; other site 1032480010971 NADP binding site [chemical binding]; other site 1032480010972 tetramer interface [polypeptide binding]; other site 1032480010973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480010974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010975 Coenzyme A binding pocket [chemical binding]; other site 1032480010976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010977 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1032480010978 Coenzyme A binding pocket [chemical binding]; other site 1032480010979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480010980 Coenzyme A binding pocket [chemical binding]; other site 1032480010981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480010983 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1032480010984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 1032480010985 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480010986 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480010987 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480010988 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480010989 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480010990 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480010991 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480010992 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1032480010993 active site 1032480010994 catalytic motif [active] 1032480010995 Zn binding site [ion binding]; other site 1032480010996 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1032480010997 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1032480010998 Integrase core domain; Region: rve; pfam00665 1032480010999 Helix-turn-helix domain; Region: HTH_38; pfam13936 1032480011000 HTH-like domain; Region: HTH_21; pfam13276 1032480011001 Integrase core domain; Region: rve; pfam00665 1032480011002 Integrase core domain; Region: rve_3; pfam13683 1032480011003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480011004 Transposase; Region: HTH_Tnp_1; pfam01527 1032480011005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480011006 putative acetyltransferase; Provisional; Region: PRK03624 1032480011007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480011008 Coenzyme A binding pocket [chemical binding]; other site 1032480011009 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1032480011010 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480011011 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480011012 catalytic core [active] 1032480011013 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480011014 active site 1032480011015 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480011016 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011017 active site 1032480011018 ATP binding site [chemical binding]; other site 1032480011019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011020 substrate binding site [chemical binding]; other site 1032480011021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011022 putative transporter; Provisional; Region: PRK10504 1032480011023 putative substrate translocation pore; other site 1032480011024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1032480011027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480011028 Coenzyme A binding pocket [chemical binding]; other site 1032480011029 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1032480011030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480011031 S-adenosylmethionine binding site [chemical binding]; other site 1032480011032 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480011033 E3 interaction surface; other site 1032480011034 lipoyl attachment site [posttranslational modification]; other site 1032480011035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011036 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1032480011037 NAD(P) binding site [chemical binding]; other site 1032480011038 active site 1032480011039 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480011040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480011041 Walker A motif; other site 1032480011042 ATP binding site [chemical binding]; other site 1032480011043 Walker B motif; other site 1032480011044 arginine finger; other site 1032480011045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480011046 Integrase core domain; Region: rve; pfam00665 1032480011047 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480011048 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011049 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1032480011050 metal binding triad [ion binding]; metal-binding site 1032480011051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480011052 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480011053 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011055 active site 1032480011056 phosphorylation site [posttranslational modification] 1032480011057 intermolecular recognition site; other site 1032480011058 dimerization interface [polypeptide binding]; other site 1032480011059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011060 DNA binding residues [nucleotide binding] 1032480011061 dimerization interface [polypeptide binding]; other site 1032480011062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480011063 Histidine kinase; Region: HisKA_3; pfam07730 1032480011064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480011065 ATP binding site [chemical binding]; other site 1032480011066 Mg2+ binding site [ion binding]; other site 1032480011067 G-X-G motif; other site 1032480011068 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1032480011069 EamA-like transporter family; Region: EamA; pfam00892 1032480011070 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1032480011071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480011072 DNA-binding site [nucleotide binding]; DNA binding site 1032480011073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480011074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011075 homodimer interface [polypeptide binding]; other site 1032480011076 catalytic residue [active] 1032480011077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011079 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1032480011080 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1032480011081 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480011082 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011083 active site 1032480011084 ATP binding site [chemical binding]; other site 1032480011085 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1032480011086 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1032480011087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011089 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480011090 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480011091 intersubunit interface [polypeptide binding]; other site 1032480011092 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1032480011093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1032480011094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011095 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1032480011096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480011097 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480011098 active site 1032480011099 catalytic tetrad [active] 1032480011100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480011102 NAD(P) binding site [chemical binding]; other site 1032480011103 active site 1032480011104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480011105 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480011106 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1032480011107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1032480011108 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1032480011109 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1032480011110 metal binding site [ion binding]; metal-binding site 1032480011111 substrate binding pocket [chemical binding]; other site 1032480011112 choline dehydrogenase; Validated; Region: PRK02106 1032480011113 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1032480011114 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1032480011115 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1032480011116 NAD(P) binding site [chemical binding]; other site 1032480011117 catalytic residues [active] 1032480011118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480011119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480011120 active site 1032480011121 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1032480011122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480011123 Walker A motif; other site 1032480011124 ATP binding site [chemical binding]; other site 1032480011125 Walker B motif; other site 1032480011126 arginine finger; other site 1032480011127 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1032480011128 Cupin; Region: Cupin_6; pfam12852 1032480011129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480011130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011131 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1032480011132 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1032480011133 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1032480011134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1032480011135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011136 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480011137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011138 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1032480011139 excinuclease ABC subunit B; Provisional; Region: PRK05298 1032480011140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480011141 putative Mg++ binding site [ion binding]; other site 1032480011142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480011143 nucleotide binding region [chemical binding]; other site 1032480011144 ATP-binding site [chemical binding]; other site 1032480011145 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1032480011146 UvrB/uvrC motif; Region: UVR; pfam02151 1032480011147 Double zinc ribbon; Region: DZR; pfam12773 1032480011148 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1032480011149 Protease prsW family; Region: PrsW-protease; pfam13367 1032480011150 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1032480011151 dephospho-CoA kinase; Region: TIGR00152 1032480011152 CoA-binding site [chemical binding]; other site 1032480011153 ATP-binding [chemical binding]; other site 1032480011154 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1032480011155 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1032480011156 RNA binding site [nucleotide binding]; other site 1032480011157 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1032480011158 RNA binding site [nucleotide binding]; other site 1032480011159 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1032480011160 RNA binding site [nucleotide binding]; other site 1032480011161 S1 RNA binding domain; Region: S1; pfam00575 1032480011162 RNA binding site [nucleotide binding]; other site 1032480011163 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1032480011164 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1032480011165 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1032480011166 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1032480011167 DNA polymerase I; Provisional; Region: PRK05755 1032480011168 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1032480011169 active site 1032480011170 metal binding site 1 [ion binding]; metal-binding site 1032480011171 putative 5' ssDNA interaction site; other site 1032480011172 metal binding site 3; metal-binding site 1032480011173 metal binding site 2 [ion binding]; metal-binding site 1032480011174 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1032480011175 putative DNA binding site [nucleotide binding]; other site 1032480011176 putative metal binding site [ion binding]; other site 1032480011177 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1032480011178 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1032480011179 active site 1032480011180 DNA binding site [nucleotide binding] 1032480011181 catalytic site [active] 1032480011182 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1032480011183 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1032480011184 putative active site [active] 1032480011185 glycerol kinase; Provisional; Region: glpK; PRK00047 1032480011186 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1032480011187 N- and C-terminal domain interface [polypeptide binding]; other site 1032480011188 active site 1032480011189 MgATP binding site [chemical binding]; other site 1032480011190 catalytic site [active] 1032480011191 metal binding site [ion binding]; metal-binding site 1032480011192 putative homotetramer interface [polypeptide binding]; other site 1032480011193 glycerol binding site [chemical binding]; other site 1032480011194 homodimer interface [polypeptide binding]; other site 1032480011195 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1032480011196 amphipathic channel; other site 1032480011197 Asn-Pro-Ala signature motifs; other site 1032480011198 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1032480011199 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1032480011200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1032480011201 DNA binding residues [nucleotide binding] 1032480011202 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1032480011203 allantoinase; Region: allantoinase; TIGR03178 1032480011204 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480011205 active site 1032480011206 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1032480011207 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1032480011208 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1032480011209 Na binding site [ion binding]; other site 1032480011210 putative substrate binding site [chemical binding]; other site 1032480011211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480011212 non-specific DNA binding site [nucleotide binding]; other site 1032480011213 salt bridge; other site 1032480011214 sequence-specific DNA binding site [nucleotide binding]; other site 1032480011215 Cupin domain; Region: Cupin_2; pfam07883 1032480011216 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1032480011217 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1032480011218 Walker A/P-loop; other site 1032480011219 ATP binding site [chemical binding]; other site 1032480011220 Q-loop/lid; other site 1032480011221 ABC transporter signature motif; other site 1032480011222 Walker B; other site 1032480011223 D-loop; other site 1032480011224 H-loop/switch region; other site 1032480011225 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1032480011226 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1032480011227 Walker A/P-loop; other site 1032480011228 ATP binding site [chemical binding]; other site 1032480011229 Q-loop/lid; other site 1032480011230 ABC transporter signature motif; other site 1032480011231 Walker B; other site 1032480011232 D-loop; other site 1032480011233 H-loop/switch region; other site 1032480011234 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1032480011235 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1032480011236 TM-ABC transporter signature motif; other site 1032480011237 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1032480011238 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1032480011239 TM-ABC transporter signature motif; other site 1032480011240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1032480011241 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1032480011242 dimerization interface [polypeptide binding]; other site 1032480011243 ligand binding site [chemical binding]; other site 1032480011244 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1032480011245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011246 active site 1032480011247 phosphorylation site [posttranslational modification] 1032480011248 intermolecular recognition site; other site 1032480011249 dimerization interface [polypeptide binding]; other site 1032480011250 ANTAR domain; Region: ANTAR; pfam03861 1032480011251 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1032480011252 pyruvate kinase; Provisional; Region: PRK06247 1032480011253 domain interfaces; other site 1032480011254 active site 1032480011255 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1032480011256 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1032480011257 RNA binding surface [nucleotide binding]; other site 1032480011258 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1032480011259 active site 1032480011260 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1032480011261 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1032480011262 DivIVA protein; Region: DivIVA; pfam05103 1032480011263 DivIVA domain; Region: DivI1A_domain; TIGR03544 1032480011264 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1032480011265 V-type ATP synthase subunit E; Provisional; Region: PRK02292 1032480011266 YGGT family; Region: YGGT; cl00508 1032480011267 Protein of unknown function (DUF552); Region: DUF552; cl00775 1032480011268 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1032480011269 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1032480011270 nucleotide binding site [chemical binding]; other site 1032480011271 SulA interaction site; other site 1032480011272 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1032480011273 Cell division protein FtsQ; Region: FtsQ; pfam03799 1032480011274 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1032480011275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480011276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480011277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480011278 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1032480011279 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1032480011280 active site 1032480011281 homodimer interface [polypeptide binding]; other site 1032480011282 cell division protein FtsW; Region: ftsW; TIGR02614 1032480011283 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1032480011284 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1032480011285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480011286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480011287 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1032480011288 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1032480011289 Mg++ binding site [ion binding]; other site 1032480011290 putative catalytic motif [active] 1032480011291 putative substrate binding site [chemical binding]; other site 1032480011292 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1032480011293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480011294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480011295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480011296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1032480011297 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1032480011298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1032480011299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1032480011300 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1032480011301 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480011302 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1032480011303 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1032480011304 MraW methylase family; Region: Methyltransf_5; cl17771 1032480011305 cell division protein MraZ; Reviewed; Region: PRK00326 1032480011306 MraZ protein; Region: MraZ; pfam02381 1032480011307 MraZ protein; Region: MraZ; pfam02381 1032480011308 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480011309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480011310 ATP binding site [chemical binding]; other site 1032480011311 Walker A motif; other site 1032480011312 Walker B motif; other site 1032480011313 arginine finger; other site 1032480011314 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1032480011315 Protein of unknown function DUF58; Region: DUF58; pfam01882 1032480011316 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480011317 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480011318 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1032480011319 putative active site [active] 1032480011320 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1032480011321 DNA polymerase IV; Validated; Region: PRK03858 1032480011322 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1032480011323 active site 1032480011324 DNA binding site [nucleotide binding] 1032480011325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480011326 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1032480011327 Rdx family; Region: Rdx; cl01407 1032480011328 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480011329 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1032480011330 substrate binding site [chemical binding]; other site 1032480011331 ATP binding site [chemical binding]; other site 1032480011332 phytoene desaturase; Region: crtI_fam; TIGR02734 1032480011333 Part of AAA domain; Region: AAA_19; pfam13245 1032480011334 Family description; Region: UvrD_C_2; pfam13538 1032480011335 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1032480011336 FAD binding site [chemical binding]; other site 1032480011337 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1032480011338 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480011339 substrate binding pocket [chemical binding]; other site 1032480011340 chain length determination region; other site 1032480011341 substrate-Mg2+ binding site; other site 1032480011342 catalytic residues [active] 1032480011343 aspartate-rich region 1; other site 1032480011344 active site lid residues [active] 1032480011345 aspartate-rich region 2; other site 1032480011346 Barstar (barnase inhibitor); Region: Barstar; pfam01337 1032480011347 RNAase interaction site [polypeptide binding]; other site 1032480011348 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1032480011349 active site 1032480011350 barstar interaction site; other site 1032480011351 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1032480011352 active site 1032480011353 thiamine phosphate binding site [chemical binding]; other site 1032480011354 pyrophosphate binding site [ion binding]; other site 1032480011355 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480011356 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1032480011357 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1032480011358 thiS-thiF/thiG interaction site; other site 1032480011359 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1032480011360 ThiS interaction site; other site 1032480011361 putative active site [active] 1032480011362 tetramer interface [polypeptide binding]; other site 1032480011363 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480011364 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1032480011365 active site 1032480011366 ATP binding site [chemical binding]; other site 1032480011367 substrate binding site [chemical binding]; other site 1032480011368 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480011369 substrate binding site [chemical binding]; other site 1032480011370 activation loop (A-loop); other site 1032480011371 activation loop (A-loop); other site 1032480011372 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480011373 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480011374 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480011375 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480011376 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1032480011377 EamA-like transporter family; Region: EamA; pfam00892 1032480011378 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1032480011379 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480011380 NAD(P) binding site [chemical binding]; other site 1032480011381 putative active site [active] 1032480011382 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1032480011383 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1032480011384 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480011385 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1032480011386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480011387 catalytic residue [active] 1032480011388 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1032480011389 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480011390 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480011391 putative acyl-acceptor binding pocket; other site 1032480011392 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480011393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1032480011394 putative acyl-acceptor binding pocket; other site 1032480011395 Esterase/lipase [General function prediction only]; Region: COG1647 1032480011396 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480011397 Bacterial SH3 domain; Region: SH3_3; pfam08239 1032480011398 Bacterial SH3 domain; Region: SH3_3; pfam08239 1032480011399 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1032480011400 NlpC/P60 family; Region: NLPC_P60; pfam00877 1032480011401 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1032480011402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1032480011403 nucleotide binding site [chemical binding]; other site 1032480011404 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1032480011405 putative hydrophobic ligand binding site [chemical binding]; other site 1032480011406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480011407 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480011408 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1032480011409 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1032480011410 NlpC/P60 family; Region: NLPC_P60; pfam00877 1032480011411 hypothetical protein; Validated; Region: PRK07883 1032480011412 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1032480011413 active site 1032480011414 catalytic site [active] 1032480011415 substrate binding site [chemical binding]; other site 1032480011416 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1032480011417 GIY-YIG motif/motif A; other site 1032480011418 active site 1032480011419 catalytic site [active] 1032480011420 putative DNA binding site [nucleotide binding]; other site 1032480011421 metal binding site [ion binding]; metal-binding site 1032480011422 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480011423 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480011424 Rhomboid family; Region: Rhomboid; pfam01694 1032480011425 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1032480011426 active site 1032480011427 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480011428 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1032480011429 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1032480011430 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1032480011431 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480011432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011433 active site 1032480011434 phosphorylation site [posttranslational modification] 1032480011435 intermolecular recognition site; other site 1032480011436 dimerization interface [polypeptide binding]; other site 1032480011437 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1032480011438 Subunit I/III interface [polypeptide binding]; other site 1032480011439 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1032480011440 Cytochrome c; Region: Cytochrom_C; pfam00034 1032480011441 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1032480011442 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1032480011443 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1032480011444 iron-sulfur cluster [ion binding]; other site 1032480011445 [2Fe-2S] cluster binding site [ion binding]; other site 1032480011446 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1032480011447 heme bH binding site [chemical binding]; other site 1032480011448 intrachain domain interface; other site 1032480011449 heme bL binding site [chemical binding]; other site 1032480011450 interchain domain interface [polypeptide binding]; other site 1032480011451 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1032480011452 Qo binding site; other site 1032480011453 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1032480011454 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1032480011455 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1032480011456 putative dimer interface [polypeptide binding]; other site 1032480011457 N-terminal domain interface [polypeptide binding]; other site 1032480011458 putative substrate binding pocket (H-site) [chemical binding]; other site 1032480011459 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1032480011460 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1032480011461 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1032480011462 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1032480011463 active site 1032480011464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480011465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011466 active site 1032480011467 phosphorylation site [posttranslational modification] 1032480011468 intermolecular recognition site; other site 1032480011469 dimerization interface [polypeptide binding]; other site 1032480011470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480011471 DNA binding site [nucleotide binding] 1032480011472 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1032480011473 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480011474 catalytic residue [active] 1032480011475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480011476 Coenzyme A binding pocket [chemical binding]; other site 1032480011477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1032480011478 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1032480011479 putative active site [active] 1032480011480 heme pocket [chemical binding]; other site 1032480011481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480011482 dimer interface [polypeptide binding]; other site 1032480011483 phosphorylation site [posttranslational modification] 1032480011484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480011485 ATP binding site [chemical binding]; other site 1032480011486 Mg2+ binding site [ion binding]; other site 1032480011487 G-X-G motif; other site 1032480011488 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1032480011489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011490 active site 1032480011491 phosphorylation site [posttranslational modification] 1032480011492 intermolecular recognition site; other site 1032480011493 dimerization interface [polypeptide binding]; other site 1032480011494 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480011495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011496 active site 1032480011497 phosphorylation site [posttranslational modification] 1032480011498 intermolecular recognition site; other site 1032480011499 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1032480011500 Response regulator receiver domain; Region: Response_reg; pfam00072 1032480011501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011502 active site 1032480011503 phosphorylation site [posttranslational modification] 1032480011504 intermolecular recognition site; other site 1032480011505 dimerization interface [polypeptide binding]; other site 1032480011506 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1032480011507 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1032480011508 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480011509 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1032480011510 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1032480011511 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1032480011512 D-pathway; other site 1032480011513 Putative ubiquinol binding site [chemical binding]; other site 1032480011514 Low-spin heme (heme b) binding site [chemical binding]; other site 1032480011515 Putative water exit pathway; other site 1032480011516 Binuclear center (heme o3/CuB) [ion binding]; other site 1032480011517 K-pathway; other site 1032480011518 Putative proton exit pathway; other site 1032480011519 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1032480011520 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1032480011521 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1032480011522 Glycerate kinase family; Region: Gly_kinase; cl00841 1032480011523 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1032480011524 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1032480011525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480011526 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480011527 active site 1032480011528 catalytic tetrad [active] 1032480011529 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1032480011530 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1032480011531 dimer interface [polypeptide binding]; other site 1032480011532 active site 1032480011533 CoA binding pocket [chemical binding]; other site 1032480011534 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1032480011535 nudix motif; other site 1032480011536 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1032480011537 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480011538 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1032480011539 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1032480011540 interface (dimer of trimers) [polypeptide binding]; other site 1032480011541 Substrate-binding/catalytic site; other site 1032480011542 Zn-binding sites [ion binding]; other site 1032480011543 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1032480011544 dimer interface [polypeptide binding]; other site 1032480011545 putative active site [active] 1032480011546 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1032480011547 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1032480011548 inhibitor-cofactor binding pocket; inhibition site 1032480011549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011550 catalytic residue [active] 1032480011551 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1032480011552 Amidinotransferase; Region: Amidinotransf; pfam02274 1032480011553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480011554 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1032480011555 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480011556 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1032480011557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480011558 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480011559 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480011560 E3 interaction surface; other site 1032480011561 lipoyl attachment site [posttranslational modification]; other site 1032480011562 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1032480011563 E3 interaction surface; other site 1032480011564 lipoyl attachment site [posttranslational modification]; other site 1032480011565 e3 binding domain; Region: E3_binding; pfam02817 1032480011566 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1032480011567 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1032480011568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011569 TIGR01777 family protein; Region: yfcH 1032480011570 NAD(P) binding site [chemical binding]; other site 1032480011571 active site 1032480011572 lipoate-protein ligase B; Provisional; Region: PRK14345 1032480011573 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1032480011574 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1032480011575 Walker A/P-loop; other site 1032480011576 ATP binding site [chemical binding]; other site 1032480011577 Q-loop/lid; other site 1032480011578 ABC transporter signature motif; other site 1032480011579 Walker B; other site 1032480011580 D-loop; other site 1032480011581 H-loop/switch region; other site 1032480011582 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1032480011583 lipoyl synthase; Provisional; Region: PRK05481 1032480011584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1032480011585 FeS/SAM binding site; other site 1032480011586 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1032480011587 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1032480011588 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480011589 ABC transporter; Region: ABC_tran_2; pfam12848 1032480011590 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1032480011591 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1032480011592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480011593 NAD(P) binding site [chemical binding]; other site 1032480011594 active site 1032480011595 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1032480011596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1032480011599 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1032480011600 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1032480011601 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1032480011602 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1032480011603 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480011604 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1032480011605 NHL repeat; Region: NHL; pfam01436 1032480011606 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1032480011607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480011608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480011609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1032480011610 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1032480011611 RDD family; Region: RDD; pfam06271 1032480011612 glutamine synthetase, type I; Region: GlnA; TIGR00653 1032480011613 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480011614 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480011615 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1032480011616 putative DNA binding helix; other site 1032480011617 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1032480011618 active site 1032480011619 NTP binding site [chemical binding]; other site 1032480011620 metal binding triad [ion binding]; metal-binding site 1032480011621 antibiotic binding site [chemical binding]; other site 1032480011622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1032480011623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1032480011624 active site 1032480011625 metal binding site [ion binding]; metal-binding site 1032480011626 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1032480011627 active site 1032480011628 metal binding site [ion binding]; metal-binding site 1032480011629 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1032480011630 Part of AAA domain; Region: AAA_19; pfam13245 1032480011631 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1032480011632 AAA domain; Region: AAA_12; pfam13087 1032480011633 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1032480011634 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1032480011635 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1032480011636 putative ADP-binding pocket [chemical binding]; other site 1032480011637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011638 putative substrate translocation pore; other site 1032480011639 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1032480011640 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1032480011641 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480011642 metal binding triad; other site 1032480011643 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480011644 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1032480011645 metal binding triad; other site 1032480011646 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1032480011647 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1032480011648 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1032480011649 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1032480011650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011651 putative substrate translocation pore; other site 1032480011652 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1032480011653 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1032480011654 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1032480011655 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480011656 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1032480011657 metal binding site 2 [ion binding]; metal-binding site 1032480011658 putative DNA binding helix; other site 1032480011659 metal binding site 1 [ion binding]; metal-binding site 1032480011660 dimer interface [polypeptide binding]; other site 1032480011661 structural Zn2+ binding site [ion binding]; other site 1032480011662 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1032480011663 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480011664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480011665 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1032480011666 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1032480011667 putative transposase OrfB; Reviewed; Region: PHA02517 1032480011668 HTH-like domain; Region: HTH_21; pfam13276 1032480011669 Integrase core domain; Region: rve; pfam00665 1032480011670 Integrase core domain; Region: rve_3; pfam13683 1032480011671 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1032480011672 active site 1032480011673 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1032480011674 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1032480011675 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1032480011676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480011678 Integrase core domain; Region: rve; pfam00665 1032480011679 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480011680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480011681 Walker A motif; other site 1032480011682 ATP binding site [chemical binding]; other site 1032480011683 Walker B motif; other site 1032480011684 arginine finger; other site 1032480011685 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480011686 putative catalytic site [active] 1032480011687 putative metal binding site [ion binding]; other site 1032480011688 putative phosphate binding site [ion binding]; other site 1032480011689 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1032480011690 RNB domain; Region: RNB; pfam00773 1032480011691 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1032480011692 Putative zinc ribbon domain; Region: DUF164; pfam02591 1032480011693 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480011694 catalytic core [active] 1032480011695 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1032480011696 proline aminopeptidase P II; Provisional; Region: PRK10879 1032480011697 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1032480011698 active site 1032480011699 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1032480011700 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1032480011701 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1032480011702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011704 DNA binding residues [nucleotide binding] 1032480011705 dimerization interface [polypeptide binding]; other site 1032480011706 Family description; Region: VCBS; pfam13517 1032480011707 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1032480011708 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1032480011709 MgtE intracellular N domain; Region: MgtE_N; smart00924 1032480011710 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1032480011711 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1032480011712 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1032480011713 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480011714 putative active site [active] 1032480011715 putative substrate binding site [chemical binding]; other site 1032480011716 ATP binding site [chemical binding]; other site 1032480011717 Domain of unknown function DUF59; Region: DUF59; cl00941 1032480011718 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1032480011719 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1032480011720 sec-independent translocase; Provisional; Region: PRK01371 1032480011721 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1032480011722 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480011723 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1032480011724 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1032480011725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480011726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480011727 DNA binding residues [nucleotide binding] 1032480011728 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1032480011729 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1032480011730 dimer interface [polypeptide binding]; other site 1032480011731 active site 1032480011732 catalytic residue [active] 1032480011733 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1032480011734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480011735 S-adenosylmethionine binding site [chemical binding]; other site 1032480011736 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480011737 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1032480011738 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1032480011739 ligand binding site; other site 1032480011740 oligomer interface; other site 1032480011741 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1032480011742 dimer interface [polypeptide binding]; other site 1032480011743 N-terminal domain interface [polypeptide binding]; other site 1032480011744 sulfate 1 binding site; other site 1032480011745 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1032480011746 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480011747 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1032480011748 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1032480011749 putative deacylase active site [active] 1032480011750 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1032480011751 enoyl-CoA hydratase; Provisional; Region: PRK06688 1032480011752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480011753 substrate binding site [chemical binding]; other site 1032480011754 oxyanion hole (OAH) forming residues; other site 1032480011755 trimer interface [polypeptide binding]; other site 1032480011756 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1032480011757 hydrophobic ligand binding site; other site 1032480011758 DivIVA domain; Region: DivI1A_domain; TIGR03544 1032480011759 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1032480011760 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1032480011761 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1032480011762 metal binding site [ion binding]; metal-binding site 1032480011763 putative dimer interface [polypeptide binding]; other site 1032480011764 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1032480011765 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1032480011766 putative trimer interface [polypeptide binding]; other site 1032480011767 putative CoA binding site [chemical binding]; other site 1032480011768 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1032480011769 putative NAD(P) binding site [chemical binding]; other site 1032480011770 homodimer interface [polypeptide binding]; other site 1032480011771 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1032480011772 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480011773 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1032480011774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480011775 metal-binding site [ion binding] 1032480011776 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1032480011777 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1032480011778 metal-binding site [ion binding] 1032480011779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480011780 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1032480011781 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480011782 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1032480011783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011784 dimerization interface [polypeptide binding]; other site 1032480011785 putative DNA binding site [nucleotide binding]; other site 1032480011786 putative Zn2+ binding site [ion binding]; other site 1032480011787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480011788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480011789 active site 1032480011790 phosphorylation site [posttranslational modification] 1032480011791 intermolecular recognition site; other site 1032480011792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480011793 DNA binding residues [nucleotide binding] 1032480011794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480011795 Histidine kinase; Region: HisKA_3; pfam07730 1032480011796 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1032480011797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480011798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480011799 homodimer interface [polypeptide binding]; other site 1032480011800 catalytic residue [active] 1032480011801 Ferredoxin [Energy production and conversion]; Region: COG1146 1032480011802 4Fe-4S binding domain; Region: Fer4; pfam00037 1032480011803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480011804 Coenzyme A binding pocket [chemical binding]; other site 1032480011805 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480011806 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480011807 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1032480011808 VanW like protein; Region: VanW; pfam04294 1032480011809 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1032480011810 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480011811 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1032480011812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480011813 Walker A/P-loop; other site 1032480011814 ATP binding site [chemical binding]; other site 1032480011815 Q-loop/lid; other site 1032480011816 ABC transporter signature motif; other site 1032480011817 Walker B; other site 1032480011818 D-loop; other site 1032480011819 H-loop/switch region; other site 1032480011820 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1032480011821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1032480011822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1032480011823 Walker A/P-loop; other site 1032480011824 ATP binding site [chemical binding]; other site 1032480011825 Q-loop/lid; other site 1032480011826 ABC transporter signature motif; other site 1032480011827 Walker B; other site 1032480011828 D-loop; other site 1032480011829 H-loop/switch region; other site 1032480011830 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1032480011831 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1032480011832 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1032480011833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011834 dimer interface [polypeptide binding]; other site 1032480011835 conserved gate region; other site 1032480011836 putative PBP binding loops; other site 1032480011837 ABC-ATPase subunit interface; other site 1032480011838 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1032480011839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480011840 dimer interface [polypeptide binding]; other site 1032480011841 conserved gate region; other site 1032480011842 putative PBP binding loops; other site 1032480011843 ABC-ATPase subunit interface; other site 1032480011844 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1032480011845 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1032480011846 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011847 substrate binding site [chemical binding]; other site 1032480011848 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480011849 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480011850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480011851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480011852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480011853 Walker A/P-loop; other site 1032480011854 ATP binding site [chemical binding]; other site 1032480011855 Q-loop/lid; other site 1032480011856 ABC transporter signature motif; other site 1032480011857 Walker B; other site 1032480011858 D-loop; other site 1032480011859 H-loop/switch region; other site 1032480011860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480011861 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480011862 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1032480011863 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1032480011864 putative ADP-binding pocket [chemical binding]; other site 1032480011865 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1032480011866 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480011867 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1032480011868 YCII-related domain; Region: YCII; cl00999 1032480011869 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480011870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480011871 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480011872 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1032480011873 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1032480011874 Zn binding site [ion binding]; other site 1032480011875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480011876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480011877 CopC domain; Region: CopC; pfam04234 1032480011878 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1032480011879 hypothetical protein; Validated; Region: PRK02101 1032480011880 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480011881 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480011882 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480011883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480011884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480011885 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 1032480011886 PLD-like domain; Region: PLDc_2; pfam13091 1032480011887 putative active site [active] 1032480011888 catalytic site [active] 1032480011889 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1032480011890 PLD-like domain; Region: PLDc_2; pfam13091 1032480011891 putative active site [active] 1032480011892 catalytic site [active] 1032480011893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480011894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480011895 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480011896 putative active site [active] 1032480011897 GTP-binding protein YchF; Reviewed; Region: PRK09601 1032480011898 YchF GTPase; Region: YchF; cd01900 1032480011899 G1 box; other site 1032480011900 GTP/Mg2+ binding site [chemical binding]; other site 1032480011901 Switch I region; other site 1032480011902 G2 box; other site 1032480011903 Switch II region; other site 1032480011904 G3 box; other site 1032480011905 G4 box; other site 1032480011906 G5 box; other site 1032480011907 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1032480011908 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1032480011909 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1032480011910 active site 1032480011911 metal binding site [ion binding]; metal-binding site 1032480011912 RmuC family; Region: RmuC; pfam02646 1032480011913 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1032480011914 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1032480011915 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1032480011916 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1032480011917 generic binding surface II; other site 1032480011918 generic binding surface I; other site 1032480011919 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1032480011920 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1032480011921 conserved cys residue [active] 1032480011922 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480011923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480011924 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1032480011925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1032480011926 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1032480011927 Class II fumarases; Region: Fumarase_classII; cd01362 1032480011928 active site 1032480011929 tetramer interface [polypeptide binding]; other site 1032480011930 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480011931 putative active site [active] 1032480011932 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1032480011933 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1032480011934 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1032480011935 putative active site [active] 1032480011936 PhoH-like protein; Region: PhoH; pfam02562 1032480011937 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1032480011938 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1032480011939 catalytic residue [active] 1032480011940 putative FPP diphosphate binding site; other site 1032480011941 putative FPP binding hydrophobic cleft; other site 1032480011942 dimer interface [polypeptide binding]; other site 1032480011943 putative IPP diphosphate binding site; other site 1032480011944 Haemolysin-III related; Region: HlyIII; pfam03006 1032480011945 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1032480011946 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1032480011947 catalytic residues [active] 1032480011948 Helix-turn-helix domain; Region: HTH_17; cl17695 1032480011949 PIN domain; Region: PIN_3; pfam13470 1032480011950 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1032480011951 Fic family protein [Function unknown]; Region: COG3177 1032480011952 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1032480011953 Fic/DOC family; Region: Fic; pfam02661 1032480011954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011955 dimerization interface [polypeptide binding]; other site 1032480011956 putative DNA binding site [nucleotide binding]; other site 1032480011957 putative Zn2+ binding site [ion binding]; other site 1032480011958 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480011959 hydrophobic ligand binding site; other site 1032480011960 YCII-related domain; Region: YCII; cl00999 1032480011961 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480011962 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480011963 intersubunit interface [polypeptide binding]; other site 1032480011964 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480011965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480011966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480011967 Walker A/P-loop; other site 1032480011968 ATP binding site [chemical binding]; other site 1032480011969 Q-loop/lid; other site 1032480011970 ABC transporter signature motif; other site 1032480011971 Walker B; other site 1032480011972 D-loop; other site 1032480011973 H-loop/switch region; other site 1032480011974 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1032480011975 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1032480011976 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1032480011977 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1032480011978 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1032480011979 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1032480011980 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480011981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480011982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480011983 putative DNA binding site [nucleotide binding]; other site 1032480011984 putative Zn2+ binding site [ion binding]; other site 1032480011985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480011986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011987 putative substrate translocation pore; other site 1032480011988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011989 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1032480011990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1032480011991 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1032480011992 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1032480011993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480011994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480011995 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1032480011996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480011997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480011998 putative substrate translocation pore; other site 1032480011999 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1032480012000 ligand binding site [chemical binding]; other site 1032480012001 active site 1032480012002 UGI interface [polypeptide binding]; other site 1032480012003 catalytic site [active] 1032480012004 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1032480012005 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1032480012006 heme-binding site [chemical binding]; other site 1032480012007 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1032480012008 FAD binding pocket [chemical binding]; other site 1032480012009 FAD binding motif [chemical binding]; other site 1032480012010 phosphate binding motif [ion binding]; other site 1032480012011 beta-alpha-beta structure motif; other site 1032480012012 NAD binding pocket [chemical binding]; other site 1032480012013 Heme binding pocket [chemical binding]; other site 1032480012014 cystathionine gamma-synthase; Provisional; Region: PRK07811 1032480012015 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1032480012016 homodimer interface [polypeptide binding]; other site 1032480012017 substrate-cofactor binding pocket; other site 1032480012018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012019 catalytic residue [active] 1032480012020 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1032480012021 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1032480012022 active site 1032480012023 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1032480012024 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1032480012025 inhibitor-cofactor binding pocket; inhibition site 1032480012026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012027 catalytic residue [active] 1032480012028 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1032480012029 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1032480012030 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1032480012031 putative trimer interface [polypeptide binding]; other site 1032480012032 putative CoA binding site [chemical binding]; other site 1032480012033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480012034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012035 potential frameshift: common BLAST hit: gi|262204503|ref|YP_003275711.1| ISRSO5-transposase 1032480012036 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480012037 Homeodomain-like domain; Region: HTH_23; pfam13384 1032480012038 Homeodomain-like domain; Region: HTH_32; pfam13565 1032480012039 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1032480012040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480012041 DNA-binding site [nucleotide binding]; DNA binding site 1032480012042 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1032480012043 Winged helix-turn helix; Region: HTH_29; pfam13551 1032480012044 Helix-turn-helix domain; Region: HTH_28; pfam13518 1032480012045 Homeodomain-like domain; Region: HTH_32; pfam13565 1032480012046 Integrase core domain; Region: rve; pfam00665 1032480012047 Integrase core domain; Region: rve_3; pfam13683 1032480012048 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1032480012049 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1032480012050 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1032480012051 catalytic residues [active] 1032480012052 catalytic nucleophile [active] 1032480012053 Presynaptic Site I dimer interface [polypeptide binding]; other site 1032480012054 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1032480012055 Synaptic Flat tetramer interface [polypeptide binding]; other site 1032480012056 Synaptic Site I dimer interface [polypeptide binding]; other site 1032480012057 DNA binding site [nucleotide binding] 1032480012058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012060 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1032480012061 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480012062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012063 putative substrate translocation pore; other site 1032480012064 TIGR03987 family protein; Region: TIGR03987 1032480012065 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1032480012066 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1032480012067 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1032480012068 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1032480012069 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1032480012070 Cysteine-rich domain; Region: CCG; pfam02754 1032480012071 Cysteine-rich domain; Region: CCG; pfam02754 1032480012072 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1032480012073 L-lactate permease; Region: Lactate_perm; cl00701 1032480012074 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1032480012075 L-lactate permease; Region: Lactate_perm; cl00701 1032480012076 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1032480012077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480012078 DNA-binding site [nucleotide binding]; DNA binding site 1032480012079 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1032480012080 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1032480012081 active site 1032480012082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480012083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012084 O-Antigen ligase; Region: Wzy_C; pfam04932 1032480012085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480012086 potential frameshift: common BLAST hit: gi|317125766|ref|YP_004099878.1| polysaccharide biosynthesis protein CapD 1032480012087 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1032480012088 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1032480012089 NAD(P) binding site [chemical binding]; other site 1032480012090 homodimer interface [polypeptide binding]; other site 1032480012091 substrate binding site [chemical binding]; other site 1032480012092 active site 1032480012093 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1032480012094 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1032480012095 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1032480012096 Ion channel; Region: Ion_trans_2; pfam07885 1032480012097 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1032480012098 TrkA-N domain; Region: TrkA_N; pfam02254 1032480012099 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1032480012100 TrkA-N domain; Region: TrkA_N; pfam02254 1032480012101 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1032480012102 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1032480012103 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480012104 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1032480012105 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1032480012106 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1032480012107 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1032480012108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480012109 S-adenosylmethionine binding site [chemical binding]; other site 1032480012110 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1032480012111 nudix motif; other site 1032480012112 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1032480012113 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1032480012114 dimer interface [polypeptide binding]; other site 1032480012115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012116 catalytic residue [active] 1032480012117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1032480012118 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1032480012119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480012121 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1032480012122 hydrophobic ligand binding site; other site 1032480012123 Predicted transcriptional regulators [Transcription]; Region: COG1733 1032480012124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012125 dimerization interface [polypeptide binding]; other site 1032480012126 putative DNA binding site [nucleotide binding]; other site 1032480012127 putative Zn2+ binding site [ion binding]; other site 1032480012128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1032480012129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012131 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1032480012132 DoxX-like family; Region: DoxX_2; pfam13564 1032480012133 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1032480012134 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1032480012135 hypothetical protein; Provisional; Region: PRK06815 1032480012136 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1032480012137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480012138 catalytic residue [active] 1032480012139 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480012140 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480012141 substrate binding site [chemical binding]; other site 1032480012142 ATP binding site [chemical binding]; other site 1032480012143 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1032480012144 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1032480012145 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1032480012146 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1032480012147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480012148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1032480012149 Putative methyltransferase; Region: Methyltransf_20; pfam12147 1032480012150 RibD C-terminal domain; Region: RibD_C; cl17279 1032480012151 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 1032480012152 metal binding site [ion binding]; metal-binding site 1032480012153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012155 DNA binding residues [nucleotide binding] 1032480012156 dimerization interface [polypeptide binding]; other site 1032480012157 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1032480012158 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1032480012159 putative active site [active] 1032480012160 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1032480012161 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1032480012162 Protein of unknown function (DUF501); Region: DUF501; cl00652 1032480012163 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1032480012164 Septum formation initiator; Region: DivIC; pfam04977 1032480012165 enolase; Provisional; Region: eno; PRK00077 1032480012166 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1032480012167 dimer interface [polypeptide binding]; other site 1032480012168 metal binding site [ion binding]; metal-binding site 1032480012169 substrate binding pocket [chemical binding]; other site 1032480012170 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1032480012171 homodimer interface [polypeptide binding]; other site 1032480012172 MazG family protein; Region: mazG; TIGR00444 1032480012173 metal binding site [ion binding]; metal-binding site 1032480012174 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1032480012175 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1032480012176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012177 ATP binding site [chemical binding]; other site 1032480012178 putative Mg++ binding site [ion binding]; other site 1032480012179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480012180 nucleotide binding region [chemical binding]; other site 1032480012181 ATP-binding site [chemical binding]; other site 1032480012182 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1032480012183 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1032480012184 putative active site [active] 1032480012185 catalytic residue [active] 1032480012186 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1032480012187 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1032480012188 5S rRNA interface [nucleotide binding]; other site 1032480012189 CTC domain interface [polypeptide binding]; other site 1032480012190 L16 interface [polypeptide binding]; other site 1032480012191 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1032480012192 oligomeric interface; other site 1032480012193 putative active site [active] 1032480012194 homodimer interface [polypeptide binding]; other site 1032480012195 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1032480012196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480012198 active site 1032480012199 phosphorylation site [posttranslational modification] 1032480012200 intermolecular recognition site; other site 1032480012201 dimerization interface [polypeptide binding]; other site 1032480012202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012203 DNA binding residues [nucleotide binding] 1032480012204 dimerization interface [polypeptide binding]; other site 1032480012205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1032480012206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480012207 Histidine kinase; Region: HisKA_3; pfam07730 1032480012208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480012209 ATP binding site [chemical binding]; other site 1032480012210 Mg2+ binding site [ion binding]; other site 1032480012211 G-X-G motif; other site 1032480012212 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1032480012213 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1032480012214 transmembrane helices; other site 1032480012215 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1032480012216 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1032480012217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012218 NAD(P) binding site [chemical binding]; other site 1032480012219 active site 1032480012220 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1032480012221 FAD binding domain; Region: FAD_binding_4; pfam01565 1032480012222 Berberine and berberine like; Region: BBE; pfam08031 1032480012223 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1032480012224 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1032480012225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480012226 active site 1032480012227 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1032480012228 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1032480012229 Substrate binding site; other site 1032480012230 Mg++ binding site; other site 1032480012231 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1032480012232 active site 1032480012233 substrate binding site [chemical binding]; other site 1032480012234 CoA binding site [chemical binding]; other site 1032480012235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480012237 active site 1032480012238 phosphorylation site [posttranslational modification] 1032480012239 intermolecular recognition site; other site 1032480012240 dimerization interface [polypeptide binding]; other site 1032480012241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012242 DNA binding residues [nucleotide binding] 1032480012243 dimerization interface [polypeptide binding]; other site 1032480012244 Putative sensor; Region: Sensor; pfam13796 1032480012245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480012246 Histidine kinase; Region: HisKA_3; pfam07730 1032480012247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480012251 putative substrate translocation pore; other site 1032480012252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012253 MarR family; Region: MarR_2; cl17246 1032480012254 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1032480012255 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1032480012256 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1032480012257 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1032480012258 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480012259 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480012260 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480012261 G5 domain; Region: G5; pfam07501 1032480012262 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1032480012263 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1032480012264 putative FMN binding site [chemical binding]; other site 1032480012265 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1032480012266 active site 1032480012267 Predicted methyltransferases [General function prediction only]; Region: COG0313 1032480012268 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1032480012269 putative SAM binding site [chemical binding]; other site 1032480012270 putative homodimer interface [polypeptide binding]; other site 1032480012271 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1032480012272 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1032480012273 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1032480012274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480012275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480012276 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1032480012277 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1032480012278 active site 1032480012279 Melibiase; Region: Melibiase; pfam02065 1032480012280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1032480012281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480012282 Coenzyme A binding pocket [chemical binding]; other site 1032480012283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012284 dimerization interface [polypeptide binding]; other site 1032480012285 putative DNA binding site [nucleotide binding]; other site 1032480012286 Predicted transcriptional regulator [Transcription]; Region: COG2345 1032480012287 putative Zn2+ binding site [ion binding]; other site 1032480012288 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1032480012289 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1032480012290 Binuclear center (active site) [active] 1032480012291 K-pathway; other site 1032480012292 Putative proton exit pathway; other site 1032480012293 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1032480012294 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1032480012295 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1032480012296 SnoaL-like domain; Region: SnoaL_2; pfam12680 1032480012297 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1032480012298 putative hydrophobic ligand binding site [chemical binding]; other site 1032480012299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012300 dimerization interface [polypeptide binding]; other site 1032480012301 putative DNA binding site [nucleotide binding]; other site 1032480012302 putative Zn2+ binding site [ion binding]; other site 1032480012303 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1032480012304 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1032480012305 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480012306 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480012307 active site 1032480012308 ATP binding site [chemical binding]; other site 1032480012309 substrate binding site [chemical binding]; other site 1032480012310 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1032480012311 active site 1032480012312 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1032480012313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1032480012314 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1032480012315 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1032480012316 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1032480012317 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480012318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012319 putative substrate translocation pore; other site 1032480012320 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1032480012321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012322 dimer interface [polypeptide binding]; other site 1032480012323 conserved gate region; other site 1032480012324 putative PBP binding loops; other site 1032480012325 ABC-ATPase subunit interface; other site 1032480012326 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1032480012327 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1032480012328 substrate binding pocket [chemical binding]; other site 1032480012329 membrane-bound complex binding site; other site 1032480012330 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1032480012331 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1032480012332 Walker A/P-loop; other site 1032480012333 ATP binding site [chemical binding]; other site 1032480012334 Q-loop/lid; other site 1032480012335 ABC transporter signature motif; other site 1032480012336 Walker B; other site 1032480012337 D-loop; other site 1032480012338 H-loop/switch region; other site 1032480012339 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1032480012340 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1032480012341 active site 1032480012342 dimer interface [polypeptide binding]; other site 1032480012343 non-prolyl cis peptide bond; other site 1032480012344 insertion regions; other site 1032480012345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012347 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1032480012348 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1032480012349 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1032480012350 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480012351 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480012352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480012355 Walker B; other site 1032480012356 D-loop; other site 1032480012357 Predicted transcriptional regulators [Transcription]; Region: COG1733 1032480012358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012359 dimerization interface [polypeptide binding]; other site 1032480012360 putative DNA binding site [nucleotide binding]; other site 1032480012361 putative Zn2+ binding site [ion binding]; other site 1032480012362 SCP-2 sterol transfer family; Region: SCP2; cl01225 1032480012363 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480012364 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012365 MarR family; Region: MarR; pfam01047 1032480012366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012367 active site 1032480012368 Predicted transcriptional regulators [Transcription]; Region: COG1733 1032480012369 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1032480012370 RibD C-terminal domain; Region: RibD_C; cl17279 1032480012371 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1032480012372 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480012373 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1032480012374 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1032480012375 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1032480012376 catalytic residues [active] 1032480012377 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012378 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1032480012379 CoenzymeA binding site [chemical binding]; other site 1032480012380 subunit interaction site [polypeptide binding]; other site 1032480012381 PHB binding site; other site 1032480012382 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1032480012383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480012384 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1032480012385 MPT binding site; other site 1032480012386 trimer interface [polypeptide binding]; other site 1032480012387 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1032480012388 trimer interface [polypeptide binding]; other site 1032480012389 dimer interface [polypeptide binding]; other site 1032480012390 putative active site [active] 1032480012391 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1032480012392 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1032480012393 dimer interface [polypeptide binding]; other site 1032480012394 putative functional site; other site 1032480012395 putative MPT binding site; other site 1032480012396 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1032480012397 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1032480012398 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1032480012399 DNA binding residues [nucleotide binding] 1032480012400 dimer interface [polypeptide binding]; other site 1032480012401 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480012402 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1032480012403 Acylphosphatase; Region: Acylphosphatase; cl00551 1032480012404 malate synthase A; Region: malate_syn_A; TIGR01344 1032480012405 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1032480012406 active site 1032480012407 isocitrate lyase; Provisional; Region: PRK15063 1032480012408 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1032480012409 tetramer interface [polypeptide binding]; other site 1032480012410 active site 1032480012411 Mg2+/Mn2+ binding site [ion binding]; other site 1032480012412 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480012413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012414 non-specific DNA binding site [nucleotide binding]; other site 1032480012415 salt bridge; other site 1032480012416 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012417 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1032480012418 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1032480012419 BRRF1-like protein; Region: Herpes_BBRF1; cl17634 1032480012420 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480012421 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480012422 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480012423 Protein of unknown function DUF45; Region: DUF45; pfam01863 1032480012424 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1032480012425 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1032480012426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012427 ATP binding site [chemical binding]; other site 1032480012428 putative Mg++ binding site [ion binding]; other site 1032480012429 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1032480012430 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1032480012431 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1032480012432 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1032480012433 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1032480012434 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1032480012435 O-methyltransferase; Region: Methyltransf_2; pfam00891 1032480012436 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480012437 MarR family; Region: MarR; pfam01047 1032480012438 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1032480012439 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1032480012440 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1032480012441 active site 1032480012442 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1032480012443 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012444 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1032480012445 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1032480012446 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1032480012447 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1032480012448 active site 1032480012449 substrate binding site; other site 1032480012450 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1032480012451 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1032480012452 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1032480012453 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480012454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1032480012455 catalytic residues [active] 1032480012456 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480012457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480012458 S-adenosylmethionine binding site [chemical binding]; other site 1032480012459 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1032480012460 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1032480012461 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1032480012462 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1032480012463 intersubunit interface [polypeptide binding]; other site 1032480012464 active site 1032480012465 zinc binding site [ion binding]; other site 1032480012466 Na+ binding site [ion binding]; other site 1032480012467 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480012468 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1032480012469 active site 1032480012470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480012471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1032480012472 nucleotide binding site [chemical binding]; other site 1032480012473 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480012474 dimer interface [polypeptide binding]; other site 1032480012475 active site 1032480012476 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480012477 dimer interface [polypeptide binding]; other site 1032480012478 active site 1032480012479 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1032480012480 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1032480012481 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1032480012482 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1032480012483 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1032480012484 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1032480012485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480012486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480012487 catalytic residue [active] 1032480012488 pyruvate carboxylase; Reviewed; Region: PRK12999 1032480012489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1032480012490 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480012491 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1032480012492 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1032480012493 active site 1032480012494 catalytic residues [active] 1032480012495 metal binding site [ion binding]; metal-binding site 1032480012496 homodimer binding site [polypeptide binding]; other site 1032480012497 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1032480012498 carboxyltransferase (CT) interaction site; other site 1032480012499 biotinylation site [posttranslational modification]; other site 1032480012500 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1032480012501 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480012502 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1032480012503 catalytic site [active] 1032480012504 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480012505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012506 putative substrate translocation pore; other site 1032480012507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012508 MarR family; Region: MarR; pfam01047 1032480012509 MarR family; Region: MarR_2; cl17246 1032480012510 MarR family; Region: MarR_2; cl17246 1032480012511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012512 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1032480012513 Copper resistance protein D; Region: CopD; pfam05425 1032480012514 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1032480012515 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1032480012516 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1032480012517 DNA-binding site [nucleotide binding]; DNA binding site 1032480012518 RNA-binding motif; other site 1032480012519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480012520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012521 putative DNA binding site [nucleotide binding]; other site 1032480012522 putative Zn2+ binding site [ion binding]; other site 1032480012523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480012524 dimerization interface [polypeptide binding]; other site 1032480012525 Transmembrane secretion effector; Region: MFS_3; pfam05977 1032480012526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012527 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1032480012528 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1032480012529 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480012530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012531 ATP binding site [chemical binding]; other site 1032480012532 putative Mg++ binding site [ion binding]; other site 1032480012533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480012534 nucleotide binding region [chemical binding]; other site 1032480012535 ATP-binding site [chemical binding]; other site 1032480012536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480012537 Ligand Binding Site [chemical binding]; other site 1032480012538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1032480012539 Ligand Binding Site [chemical binding]; other site 1032480012540 Predicted acyl esterases [General function prediction only]; Region: COG2936 1032480012541 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1032480012542 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1032480012543 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1032480012544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480012545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480012546 Walker A/P-loop; other site 1032480012547 ATP binding site [chemical binding]; other site 1032480012548 Q-loop/lid; other site 1032480012549 ABC transporter signature motif; other site 1032480012550 Walker B; other site 1032480012551 D-loop; other site 1032480012552 H-loop/switch region; other site 1032480012553 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1032480012554 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1032480012555 FtsX-like permease family; Region: FtsX; pfam02687 1032480012556 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1032480012557 HlyD family secretion protein; Region: HlyD_3; pfam13437 1032480012558 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012559 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012560 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1032480012561 putative metal binding residues [ion binding]; other site 1032480012562 signature motif; other site 1032480012563 dimer interface [polypeptide binding]; other site 1032480012564 active site 1032480012565 polyP binding site; other site 1032480012566 substrate binding site [chemical binding]; other site 1032480012567 acceptor-phosphate pocket; other site 1032480012568 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1032480012569 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1032480012570 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1032480012571 nudix motif; other site 1032480012572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012574 WHG domain; Region: WHG; pfam13305 1032480012575 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1032480012576 Part of AAA domain; Region: AAA_19; pfam13245 1032480012577 Family description; Region: UvrD_C_2; pfam13538 1032480012578 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1032480012579 dimer interface [polypeptide binding]; other site 1032480012580 catalytic triad [active] 1032480012581 CutC family; Region: CutC; cl01218 1032480012582 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480012583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480012584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480012585 DNA binding residues [nucleotide binding] 1032480012586 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1032480012587 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1032480012588 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1032480012589 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1032480012590 active site 1032480012591 dimer interface [polypeptide binding]; other site 1032480012592 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1032480012593 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1032480012594 [4Fe-4S] binding site [ion binding]; other site 1032480012595 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480012596 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480012597 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1032480012598 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1032480012599 molybdopterin cofactor binding site; other site 1032480012600 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1032480012601 4Fe-4S binding domain; Region: Fer4; cl02805 1032480012602 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480012603 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1032480012604 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1032480012605 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1032480012606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012607 putative substrate translocation pore; other site 1032480012608 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480012609 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1032480012610 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1032480012611 transmembrane helices; other site 1032480012612 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1032480012613 nudix motif; other site 1032480012614 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1032480012615 quinolinate synthetase; Provisional; Region: PRK09375 1032480012616 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1032480012617 L-aspartate oxidase; Provisional; Region: PRK06175 1032480012618 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1032480012619 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1032480012620 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1032480012621 dimerization interface [polypeptide binding]; other site 1032480012622 active site 1032480012623 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1032480012624 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1032480012625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480012626 catalytic residue [active] 1032480012627 AAA ATPase domain; Region: AAA_16; pfam13191 1032480012628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012630 DNA binding residues [nucleotide binding] 1032480012631 dimerization interface [polypeptide binding]; other site 1032480012632 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1032480012633 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1032480012634 ring oligomerisation interface [polypeptide binding]; other site 1032480012635 ATP/Mg binding site [chemical binding]; other site 1032480012636 stacking interactions; other site 1032480012637 hinge regions; other site 1032480012638 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1032480012639 homodimer interface [polypeptide binding]; other site 1032480012640 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1032480012641 active site pocket [active] 1032480012642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480012643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1032480012644 putative substrate translocation pore; other site 1032480012645 AAA domain; Region: AAA_33; pfam13671 1032480012646 AAA domain; Region: AAA_17; pfam13207 1032480012647 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1032480012648 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1032480012649 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1032480012650 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1032480012651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480012652 active site 1032480012653 motif I; other site 1032480012654 motif II; other site 1032480012655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480012656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480012657 ATP binding site [chemical binding]; other site 1032480012658 G-X-G motif; other site 1032480012659 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480012660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480012661 DNA binding residues [nucleotide binding] 1032480012662 dimerization interface [polypeptide binding]; other site 1032480012663 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1032480012664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480012665 ATP binding site [chemical binding]; other site 1032480012666 putative Mg++ binding site [ion binding]; other site 1032480012667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480012668 nucleotide binding region [chemical binding]; other site 1032480012669 ATP-binding site [chemical binding]; other site 1032480012670 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1032480012671 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1032480012672 NAD binding site [chemical binding]; other site 1032480012673 substrate binding site [chemical binding]; other site 1032480012674 catalytic Zn binding site [ion binding]; other site 1032480012675 structural Zn binding site [ion binding]; other site 1032480012676 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1032480012677 MoaE interaction surface [polypeptide binding]; other site 1032480012678 MoeB interaction surface [polypeptide binding]; other site 1032480012679 thiocarboxylated glycine; other site 1032480012680 threonine synthase; Validated; Region: PRK07591 1032480012681 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1032480012682 homodimer interface [polypeptide binding]; other site 1032480012683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480012684 catalytic residue [active] 1032480012685 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480012686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480012687 Walker A motif; other site 1032480012688 ATP binding site [chemical binding]; other site 1032480012689 Walker B motif; other site 1032480012690 arginine finger; other site 1032480012691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480012692 Integrase core domain; Region: rve; pfam00665 1032480012693 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1032480012694 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012695 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1032480012696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480012697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480012698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480012699 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 1032480012700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480012701 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1032480012702 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1032480012703 hypothetical protein; Provisional; Region: PRK11770 1032480012704 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1032480012705 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1032480012706 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1032480012707 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1032480012708 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1032480012709 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1032480012710 Walker A/P-loop; other site 1032480012711 ATP binding site [chemical binding]; other site 1032480012712 Q-loop/lid; other site 1032480012713 ABC transporter signature motif; other site 1032480012714 Walker B; other site 1032480012715 D-loop; other site 1032480012716 H-loop/switch region; other site 1032480012717 TOBE domain; Region: TOBE_2; pfam08402 1032480012718 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1032480012719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480012720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480012721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480012722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1032480012723 NAD(P) binding site [chemical binding]; other site 1032480012724 active site 1032480012725 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480012726 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1032480012727 G5 domain; Region: G5; pfam07501 1032480012728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480012729 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 1032480012730 active site 1032480012731 Helix-turn-helix domain; Region: HTH_17; cl17695 1032480012732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480012733 MarR family; Region: MarR; pfam01047 1032480012734 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1032480012735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1032480012736 active site 1032480012737 HIGH motif; other site 1032480012738 nucleotide binding site [chemical binding]; other site 1032480012739 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1032480012740 KMSKS motif; other site 1032480012741 tRNA binding surface [nucleotide binding]; other site 1032480012742 anticodon binding site; other site 1032480012743 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1032480012744 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1032480012745 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1032480012746 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1032480012747 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1032480012748 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1032480012749 dimer interface [polypeptide binding]; other site 1032480012750 active site 1032480012751 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1032480012752 folate binding site [chemical binding]; other site 1032480012753 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1032480012754 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1032480012755 Walker A/P-loop; other site 1032480012756 ATP binding site [chemical binding]; other site 1032480012757 Q-loop/lid; other site 1032480012758 ABC transporter signature motif; other site 1032480012759 Walker B; other site 1032480012760 D-loop; other site 1032480012761 H-loop/switch region; other site 1032480012762 Predicted transcriptional regulators [Transcription]; Region: COG1695 1032480012763 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1032480012764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480012765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480012766 active site 1032480012767 catalytic tetrad [active] 1032480012768 NMT1/THI5 like; Region: NMT1; pfam09084 1032480012769 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1032480012770 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1032480012771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012772 putative PBP binding loops; other site 1032480012773 dimer interface [polypeptide binding]; other site 1032480012774 ABC-ATPase subunit interface; other site 1032480012775 argininosuccinate synthase; Validated; Region: PRK05370 1032480012776 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1032480012777 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1032480012778 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1032480012779 homotrimer interaction site [polypeptide binding]; other site 1032480012780 CDP-binding sites; other site 1032480012781 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1032480012782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480012783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480012784 active site 1032480012785 phosphorylation site [posttranslational modification] 1032480012786 intermolecular recognition site; other site 1032480012787 dimerization interface [polypeptide binding]; other site 1032480012788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480012789 DNA binding site [nucleotide binding] 1032480012790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1032480012791 dimer interface [polypeptide binding]; other site 1032480012792 phosphorylation site [posttranslational modification] 1032480012793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1032480012794 ATP binding site [chemical binding]; other site 1032480012795 Mg2+ binding site [ion binding]; other site 1032480012796 G-X-G motif; other site 1032480012797 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1032480012798 PhoU domain; Region: PhoU; pfam01895 1032480012799 PhoU domain; Region: PhoU; pfam01895 1032480012800 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012801 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480012802 catalytic core [active] 1032480012803 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 1032480012804 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1032480012805 active site 1032480012806 catalytic site [active] 1032480012807 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480012808 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480012809 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1032480012810 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480012811 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1032480012812 G1 box; other site 1032480012813 GTP/Mg2+ binding site [chemical binding]; other site 1032480012814 G2 box; other site 1032480012815 Switch I region; other site 1032480012816 G3 box; other site 1032480012817 Switch II region; other site 1032480012818 G4 box; other site 1032480012819 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1032480012820 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1032480012821 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480012822 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1032480012823 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1032480012824 G1 box; other site 1032480012825 putative GEF interaction site [polypeptide binding]; other site 1032480012826 GTP/Mg2+ binding site [chemical binding]; other site 1032480012827 Switch I region; other site 1032480012828 G2 box; other site 1032480012829 G3 box; other site 1032480012830 Switch II region; other site 1032480012831 G4 box; other site 1032480012832 G5 box; other site 1032480012833 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1032480012834 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1032480012835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480012836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480012837 non-specific DNA binding site [nucleotide binding]; other site 1032480012838 salt bridge; other site 1032480012839 sequence-specific DNA binding site [nucleotide binding]; other site 1032480012840 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1032480012841 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1032480012842 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1032480012843 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1032480012844 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1032480012845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480012846 motif II; other site 1032480012847 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1032480012848 L-asparaginase II; Region: Asparaginase_II; pfam06089 1032480012849 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1032480012850 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1032480012851 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1032480012852 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1032480012853 heme-binding site [chemical binding]; other site 1032480012854 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480012855 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480012856 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480012857 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1032480012858 conserved cys residue [active] 1032480012859 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480012860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012861 dimer interface [polypeptide binding]; other site 1032480012862 conserved gate region; other site 1032480012863 putative PBP binding loops; other site 1032480012864 ABC-ATPase subunit interface; other site 1032480012865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012866 dimer interface [polypeptide binding]; other site 1032480012867 conserved gate region; other site 1032480012868 putative PBP binding loops; other site 1032480012869 ABC-ATPase subunit interface; other site 1032480012870 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1032480012871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480012872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480012873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480012874 DNA binding site [nucleotide binding] 1032480012875 domain linker motif; other site 1032480012876 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480012877 dimerization interface [polypeptide binding]; other site 1032480012878 ligand binding site [chemical binding]; other site 1032480012879 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 1032480012880 putative active site [active] 1032480012881 dimerization interface [polypeptide binding]; other site 1032480012882 putative tRNAtyr binding site [nucleotide binding]; other site 1032480012883 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1032480012884 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1032480012885 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1032480012886 active site residue [active] 1032480012887 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1032480012888 active site residue [active] 1032480012889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1032480012890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1032480012891 DNA binding site [nucleotide binding] 1032480012892 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1032480012893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480012894 Coenzyme A binding pocket [chemical binding]; other site 1032480012895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480012896 Coenzyme A binding pocket [chemical binding]; other site 1032480012897 polyphosphate kinase; Provisional; Region: PRK05443 1032480012898 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1032480012899 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1032480012900 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1032480012901 putative domain interface [polypeptide binding]; other site 1032480012902 putative active site [active] 1032480012903 catalytic site [active] 1032480012904 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1032480012905 putative domain interface [polypeptide binding]; other site 1032480012906 putative active site [active] 1032480012907 catalytic site [active] 1032480012908 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1032480012909 active site 1032480012910 Ap6A binding site [chemical binding]; other site 1032480012911 nudix motif; other site 1032480012912 metal binding site [ion binding]; metal-binding site 1032480012913 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1032480012914 catalytic core [active] 1032480012915 PBP superfamily domain; Region: PBP_like_2; cl17296 1032480012916 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1032480012917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012918 dimer interface [polypeptide binding]; other site 1032480012919 conserved gate region; other site 1032480012920 putative PBP binding loops; other site 1032480012921 ABC-ATPase subunit interface; other site 1032480012922 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1032480012923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480012924 dimer interface [polypeptide binding]; other site 1032480012925 conserved gate region; other site 1032480012926 putative PBP binding loops; other site 1032480012927 ABC-ATPase subunit interface; other site 1032480012928 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1032480012929 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1032480012930 Walker A/P-loop; other site 1032480012931 ATP binding site [chemical binding]; other site 1032480012932 Q-loop/lid; other site 1032480012933 ABC transporter signature motif; other site 1032480012934 Walker B; other site 1032480012935 D-loop; other site 1032480012936 H-loop/switch region; other site 1032480012937 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1032480012938 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1032480012939 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1032480012940 mycothione reductase; Reviewed; Region: PRK07846 1032480012941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480012942 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1032480012943 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1032480012944 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1032480012945 active site residue [active] 1032480012946 High-affinity nickel-transport protein; Region: NicO; cl00964 1032480012947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480012948 dimerization interface [polypeptide binding]; other site 1032480012949 putative DNA binding site [nucleotide binding]; other site 1032480012950 putative Zn2+ binding site [ion binding]; other site 1032480012951 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1032480012952 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1032480012953 YCII-related domain; Region: YCII; cl00999 1032480012954 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1032480012955 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1032480012956 ResB-like family; Region: ResB; pfam05140 1032480012957 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1032480012958 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480012959 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1032480012960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1032480012961 catalytic residues [active] 1032480012962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1032480012963 catalytic core [active] 1032480012964 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1032480012965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1032480012966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1032480012967 catalytic residue [active] 1032480012968 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1032480012969 dimer interface [polypeptide binding]; other site 1032480012970 active site 1032480012971 Schiff base residues; other site 1032480012972 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1032480012973 active site 1032480012974 homodimer interface [polypeptide binding]; other site 1032480012975 SAM binding site [chemical binding]; other site 1032480012976 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1032480012977 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1032480012978 active site 1032480012979 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1032480012980 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1032480012981 domain interfaces; other site 1032480012982 active site 1032480012983 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1032480012984 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1032480012985 tRNA; other site 1032480012986 putative tRNA binding site [nucleotide binding]; other site 1032480012987 putative NADP binding site [chemical binding]; other site 1032480012988 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1032480012989 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1032480012990 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1032480012991 CoA binding domain; Region: CoA_binding; pfam02629 1032480012992 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1032480012993 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1032480012994 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1032480012995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480012996 acyl-activating enzyme (AAE) consensus motif; other site 1032480012997 AMP binding site [chemical binding]; other site 1032480012998 active site 1032480012999 CoA binding site [chemical binding]; other site 1032480013000 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1032480013001 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1032480013002 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1032480013003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1032480013004 putative acyl-acceptor binding pocket; other site 1032480013005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1032480013006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480013007 NAD(P) binding site [chemical binding]; other site 1032480013008 active site 1032480013009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1032480013010 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1032480013011 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1032480013012 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1032480013013 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1032480013014 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1032480013015 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1032480013016 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1032480013017 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1032480013018 DNA binding domain, excisionase family; Region: excise; TIGR01764 1032480013019 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1032480013020 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1032480013021 active site 1032480013022 Zn binding site [ion binding]; other site 1032480013023 pyrroline-5-carboxylate reductase; Region: PLN02688 1032480013024 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1032480013025 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1032480013026 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1032480013027 CAAX protease self-immunity; Region: Abi; pfam02517 1032480013028 Proline dehydrogenase; Region: Pro_dh; cl03282 1032480013029 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480013030 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1032480013031 AP (apurinic/apyrimidinic) site pocket; other site 1032480013032 DNA interaction; other site 1032480013033 Metal-binding active site; metal-binding site 1032480013034 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1032480013035 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1032480013036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480013037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480013038 homodimer interface [polypeptide binding]; other site 1032480013039 catalytic residue [active] 1032480013040 DNA repair protein RadA; Provisional; Region: PRK11823 1032480013041 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1032480013042 Walker A motif; other site 1032480013043 ATP binding site [chemical binding]; other site 1032480013044 Walker B motif; other site 1032480013045 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1032480013046 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1032480013047 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1032480013048 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1032480013049 Helix-hairpin-helix motif; Region: HHH; pfam00633 1032480013050 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480013051 endonuclease III; Region: ENDO3c; smart00478 1032480013052 minor groove reading motif; other site 1032480013053 helix-hairpin-helix signature motif; other site 1032480013054 substrate binding pocket [chemical binding]; other site 1032480013055 active site 1032480013056 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1032480013057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1032480013058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1032480013059 active site 1032480013060 catalytic tetrad [active] 1032480013061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480013062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480013063 Clp protease ATP binding subunit; Region: clpC; CHL00095 1032480013064 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480013065 Clp amino terminal domain; Region: Clp_N; pfam02861 1032480013066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013067 Walker A motif; other site 1032480013068 ATP binding site [chemical binding]; other site 1032480013069 Walker B motif; other site 1032480013070 arginine finger; other site 1032480013071 UvrB/uvrC motif; Region: UVR; pfam02151 1032480013072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013073 Walker A motif; other site 1032480013074 ATP binding site [chemical binding]; other site 1032480013075 Walker B motif; other site 1032480013076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1032480013077 Lsr2; Region: Lsr2; pfam11774 1032480013078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480013079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480013080 Zeta toxin; Region: Zeta_toxin; pfam06414 1032480013081 MarR family; Region: MarR_2; cl17246 1032480013082 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1032480013083 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1032480013084 catalytic center binding site [active] 1032480013085 ATP binding site [chemical binding]; other site 1032480013086 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1032480013087 homooctamer interface [polypeptide binding]; other site 1032480013088 active site 1032480013089 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1032480013090 dihydropteroate synthase; Region: DHPS; TIGR01496 1032480013091 substrate binding pocket [chemical binding]; other site 1032480013092 dimer interface [polypeptide binding]; other site 1032480013093 inhibitor binding site; inhibition site 1032480013094 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1032480013095 homodecamer interface [polypeptide binding]; other site 1032480013096 GTP cyclohydrolase I; Provisional; Region: PLN03044 1032480013097 active site 1032480013098 putative catalytic site residues [active] 1032480013099 zinc binding site [ion binding]; other site 1032480013100 GTP-CH-I/GFRP interaction surface; other site 1032480013101 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1032480013102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013103 Walker A motif; other site 1032480013104 ATP binding site [chemical binding]; other site 1032480013105 Walker B motif; other site 1032480013106 arginine finger; other site 1032480013107 Peptidase family M41; Region: Peptidase_M41; pfam01434 1032480013108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480013109 active site 1032480013110 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1032480013111 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1032480013112 Ligand Binding Site [chemical binding]; other site 1032480013113 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1032480013114 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1032480013115 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1032480013116 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1032480013117 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1032480013118 dimer interface [polypeptide binding]; other site 1032480013119 substrate binding site [chemical binding]; other site 1032480013120 metal binding sites [ion binding]; metal-binding site 1032480013121 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480013122 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1032480013123 active site 1032480013124 catalytic residues [active] 1032480013125 catalytic residues [active] 1032480013126 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1032480013127 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1032480013128 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1032480013129 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1032480013130 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1032480013131 serine O-acetyltransferase; Region: cysE; TIGR01172 1032480013132 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1032480013133 trimer interface [polypeptide binding]; other site 1032480013134 active site 1032480013135 substrate binding site [chemical binding]; other site 1032480013136 CoA binding site [chemical binding]; other site 1032480013137 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1032480013138 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1032480013139 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1032480013140 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1032480013141 trimer interface [polypeptide binding]; other site 1032480013142 active site 1032480013143 substrate binding site [chemical binding]; other site 1032480013144 CoA binding site [chemical binding]; other site 1032480013145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480013146 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1032480013147 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1032480013148 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1032480013149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1032480013150 active site 1032480013151 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1032480013152 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1032480013153 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1032480013154 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480013155 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1032480013156 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1032480013157 Probable Catalytic site; other site 1032480013158 metal-binding site 1032480013159 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480013160 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480013161 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480013162 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480013163 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480013164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1032480013165 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480013166 Interdomain contacts; other site 1032480013167 Cytokine receptor motif; other site 1032480013168 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1032480013169 Interdomain contacts; other site 1032480013170 Cytokine receptor motif; other site 1032480013171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1032480013172 active site 1032480013173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480013174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013175 Walker A/P-loop; other site 1032480013176 ATP binding site [chemical binding]; other site 1032480013177 Q-loop/lid; other site 1032480013178 ABC transporter signature motif; other site 1032480013179 Walker B; other site 1032480013180 D-loop; other site 1032480013181 H-loop/switch region; other site 1032480013182 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480013183 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480013184 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480013185 NAD synthetase; Reviewed; Region: nadE; PRK00876 1032480013186 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1032480013187 homodimer interface [polypeptide binding]; other site 1032480013188 NAD binding pocket [chemical binding]; other site 1032480013189 ATP binding pocket [chemical binding]; other site 1032480013190 Mg binding site [ion binding]; other site 1032480013191 active-site loop [active] 1032480013192 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1032480013193 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1032480013194 active site 1032480013195 dimer interface [polypeptide binding]; other site 1032480013196 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1032480013197 Ligand Binding Site [chemical binding]; other site 1032480013198 Molecular Tunnel; other site 1032480013199 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1032480013200 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1032480013201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480013202 acyl-activating enzyme (AAE) consensus motif; other site 1032480013203 AMP binding site [chemical binding]; other site 1032480013204 active site 1032480013205 CoA binding site [chemical binding]; other site 1032480013206 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1032480013207 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480013208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013209 Walker A/P-loop; other site 1032480013210 ATP binding site [chemical binding]; other site 1032480013211 Q-loop/lid; other site 1032480013212 ABC transporter signature motif; other site 1032480013213 Walker B; other site 1032480013214 D-loop; other site 1032480013215 H-loop/switch region; other site 1032480013216 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1032480013217 active site 1032480013218 metal-binding site [ion binding] 1032480013219 nucleotide-binding site [chemical binding]; other site 1032480013220 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1032480013221 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480013222 Ligand Binding Site [chemical binding]; other site 1032480013223 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1032480013224 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1032480013225 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1032480013226 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1032480013227 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1032480013228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480013229 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1032480013230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480013231 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1032480013232 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1032480013233 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1032480013234 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1032480013235 putative active site [active] 1032480013236 putative metal binding site [ion binding]; other site 1032480013237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1032480013238 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480013239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480013240 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1032480013241 active site 1032480013242 catalytic residues [active] 1032480013243 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1032480013244 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1032480013245 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1032480013246 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1032480013247 CysD dimerization site [polypeptide binding]; other site 1032480013248 G1 box; other site 1032480013249 putative GEF interaction site [polypeptide binding]; other site 1032480013250 GTP/Mg2+ binding site [chemical binding]; other site 1032480013251 Switch I region; other site 1032480013252 G2 box; other site 1032480013253 G3 box; other site 1032480013254 Switch II region; other site 1032480013255 G4 box; other site 1032480013256 G5 box; other site 1032480013257 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1032480013258 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1032480013259 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1032480013260 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1032480013261 Active Sites [active] 1032480013262 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480013263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480013264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480013265 metabolite-proton symporter; Region: 2A0106; TIGR00883 1032480013266 putative substrate translocation pore; other site 1032480013267 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1032480013268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480013269 S-adenosylmethionine binding site [chemical binding]; other site 1032480013270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1032480013271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1032480013272 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1032480013273 MoxR-like ATPases [General function prediction only]; Region: COG0714 1032480013274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1032480013275 Walker B motif; other site 1032480013276 arginine finger; other site 1032480013277 Protein of unknown function DUF58; Region: DUF58; pfam01882 1032480013278 AAA domain; Region: AAA_33; pfam13671 1032480013279 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1032480013280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1032480013281 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1032480013282 TIGR04255 family protein; Region: sporadTIGR04255 1032480013283 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480013284 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480013285 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480013286 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1032480013287 putative active site [active] 1032480013288 putative NTP binding site [chemical binding]; other site 1032480013289 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1032480013290 putative nucleic acid binding site [nucleotide binding]; other site 1032480013291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480013292 Transposase; Region: HTH_Tnp_1; cl17663 1032480013293 putative transposase OrfB; Reviewed; Region: PHA02517 1032480013294 HTH-like domain; Region: HTH_21; pfam13276 1032480013295 Integrase core domain; Region: rve; pfam00665 1032480013296 Integrase core domain; Region: rve_3; pfam13683 1032480013297 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1032480013298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480013299 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1032480013300 synthetase active site [active] 1032480013301 NTP binding site [chemical binding]; other site 1032480013302 metal binding site [ion binding]; metal-binding site 1032480013303 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1032480013304 homotrimer interaction site [polypeptide binding]; other site 1032480013305 zinc binding site [ion binding]; other site 1032480013306 CDP-binding sites; other site 1032480013307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480013309 non-specific DNA binding site [nucleotide binding]; other site 1032480013310 salt bridge; other site 1032480013311 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013312 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1032480013313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480013314 motif II; other site 1032480013315 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480013316 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1032480013317 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480013318 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1032480013319 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1032480013320 Int/Topo IB signature motif; other site 1032480013321 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1032480013322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013323 non-specific DNA binding site [nucleotide binding]; other site 1032480013324 salt bridge; other site 1032480013325 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013326 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 1032480013327 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1032480013328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1032480013329 motif II; other site 1032480013330 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1032480013331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1032480013332 DNA-binding site [nucleotide binding]; DNA binding site 1032480013333 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480013334 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1032480013335 Helix-turn-helix domain; Region: HTH_17; pfam12728 1032480013336 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1032480013337 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013339 active site 1032480013340 DNA binding site [nucleotide binding] 1032480013341 Int/Topo IB signature motif; other site 1032480013342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1032480013343 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480013344 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1032480013345 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1032480013346 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1032480013347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1032480013348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1032480013349 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1032480013350 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1032480013351 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1032480013352 thymidylate kinase; Validated; Region: tmk; PRK00698 1032480013353 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1032480013354 TMP-binding site; other site 1032480013355 ATP-binding site [chemical binding]; other site 1032480013356 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1032480013357 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1032480013358 active site 1032480013359 interdomain interaction site; other site 1032480013360 putative metal-binding site [ion binding]; other site 1032480013361 nucleotide binding site [chemical binding]; other site 1032480013362 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1032480013363 domain I; other site 1032480013364 DNA binding groove [nucleotide binding] 1032480013365 phosphate binding site [ion binding]; other site 1032480013366 domain II; other site 1032480013367 domain III; other site 1032480013368 nucleotide binding site [chemical binding]; other site 1032480013369 catalytic site [active] 1032480013370 domain IV; other site 1032480013371 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480013372 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480013373 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480013374 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1032480013375 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1032480013376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480013377 S-adenosylmethionine binding site [chemical binding]; other site 1032480013378 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1032480013379 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480013380 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480013381 intersubunit interface [polypeptide binding]; other site 1032480013382 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1032480013383 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1032480013384 Walker A/P-loop; other site 1032480013385 ATP binding site [chemical binding]; other site 1032480013386 Q-loop/lid; other site 1032480013387 ABC transporter signature motif; other site 1032480013388 Walker B; other site 1032480013389 D-loop; other site 1032480013390 H-loop/switch region; other site 1032480013391 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1032480013392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480013393 ABC-ATPase subunit interface; other site 1032480013394 dimer interface [polypeptide binding]; other site 1032480013395 putative PBP binding regions; other site 1032480013396 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1032480013397 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1032480013398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480013399 ABC-ATPase subunit interface; other site 1032480013400 dimer interface [polypeptide binding]; other site 1032480013401 putative PBP binding regions; other site 1032480013402 CAAX protease self-immunity; Region: Abi; pfam02517 1032480013403 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1032480013404 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1032480013405 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1032480013406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480013407 putative Mg++ binding site [ion binding]; other site 1032480013408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480013409 nucleotide binding region [chemical binding]; other site 1032480013410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1032480013411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1032480013412 Helix-turn-helix domain; Region: HTH_18; pfam12833 1032480013413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1032480013414 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480013415 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480013416 homodimer interface [polypeptide binding]; other site 1032480013417 active site 1032480013418 TDP-binding site; other site 1032480013419 acceptor substrate-binding pocket; other site 1032480013420 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1032480013421 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1032480013422 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1032480013423 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1032480013424 ATP binding site [chemical binding]; other site 1032480013425 Walker A motif; other site 1032480013426 hexamer interface [polypeptide binding]; other site 1032480013427 Walker B motif; other site 1032480013428 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1032480013429 Fic family protein [Function unknown]; Region: COG3177 1032480013430 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1032480013431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480013432 S-adenosylmethionine binding site [chemical binding]; other site 1032480013433 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1032480013434 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1032480013435 dimer interface [polypeptide binding]; other site 1032480013436 active site 1032480013437 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1032480013438 dimer interface [polypeptide binding]; other site 1032480013439 active site 1032480013440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480013441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480013442 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1032480013443 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1032480013444 active site 1032480013445 TDP-binding site; other site 1032480013446 acceptor substrate-binding pocket; other site 1032480013447 acetyl-CoA synthetase; Provisional; Region: PRK00174 1032480013448 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1032480013449 active site 1032480013450 CoA binding site [chemical binding]; other site 1032480013451 acyl-activating enzyme (AAE) consensus motif; other site 1032480013452 AMP binding site [chemical binding]; other site 1032480013453 acetate binding site [chemical binding]; other site 1032480013454 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1032480013455 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480013456 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1032480013457 PGAP1-like protein; Region: PGAP1; pfam07819 1032480013458 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1032480013459 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1032480013460 Ca binding site [ion binding]; other site 1032480013461 active site 1032480013462 catalytic site [active] 1032480013463 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1032480013464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1032480013465 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1032480013466 putative active site [active] 1032480013467 putative CoA binding site [chemical binding]; other site 1032480013468 nudix motif; other site 1032480013469 metal binding site [ion binding]; metal-binding site 1032480013470 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1032480013471 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1032480013472 minor groove reading motif; other site 1032480013473 helix-hairpin-helix signature motif; other site 1032480013474 substrate binding pocket [chemical binding]; other site 1032480013475 active site 1032480013476 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1032480013477 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1032480013478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1032480013479 ligand binding site [chemical binding]; other site 1032480013480 flexible hinge region; other site 1032480013481 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1032480013482 putative switch regulator; other site 1032480013483 non-specific DNA interactions [nucleotide binding]; other site 1032480013484 DNA binding site [nucleotide binding] 1032480013485 sequence specific DNA binding site [nucleotide binding]; other site 1032480013486 putative cAMP binding site [chemical binding]; other site 1032480013487 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1032480013488 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1032480013489 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1032480013490 NUDIX domain; Region: NUDIX; pfam00293 1032480013491 nudix motif; other site 1032480013492 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1032480013493 homotrimer interaction site [polypeptide binding]; other site 1032480013494 putative active site [active] 1032480013495 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1032480013496 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480013497 HTH-like domain; Region: HTH_21; pfam13276 1032480013498 Integrase core domain; Region: rve; pfam00665 1032480013499 Integrase core domain; Region: rve_3; pfam13683 1032480013500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480013501 Transposase; Region: HTH_Tnp_1; pfam01527 1032480013502 active site 1032480013503 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1032480013504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480013505 Transposase; Region: HTH_Tnp_1; cl17663 1032480013506 putative transposase OrfB; Reviewed; Region: PHA02517 1032480013507 HTH-like domain; Region: HTH_21; pfam13276 1032480013508 Integrase core domain; Region: rve; pfam00665 1032480013509 Integrase core domain; Region: rve_3; pfam13683 1032480013510 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1032480013511 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480013512 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1032480013513 P loop; other site 1032480013514 Nucleotide binding site [chemical binding]; other site 1032480013515 DTAP/Switch II; other site 1032480013516 Switch I; other site 1032480013517 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1032480013518 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480013519 P loop; other site 1032480013520 Nucleotide binding site [chemical binding]; other site 1032480013521 DTAP/Switch II; other site 1032480013522 Switch I; other site 1032480013523 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1032480013524 Transcription factor WhiB; Region: Whib; pfam02467 1032480013525 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1032480013526 Transglycosylase; Region: Transgly; pfam00912 1032480013527 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1032480013528 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480013529 Yqey-like protein; Region: YqeY; pfam09424 1032480013530 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1032480013531 phosphodiesterase YaeI; Provisional; Region: PRK11340 1032480013532 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1032480013533 putative active site [active] 1032480013534 putative metal binding site [ion binding]; other site 1032480013535 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1032480013536 potential frameshift: common BLAST hit: gi|229819264|ref|YP_002880790.1| conserved repeat domain protein 1032480013537 Domain of unknown function DUF11; Region: DUF11; cl17728 1032480013538 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1032480013539 Sulfatase; Region: Sulfatase; cl17466 1032480013540 aspartate kinase; Reviewed; Region: PRK06635 1032480013541 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1032480013542 putative nucleotide binding site [chemical binding]; other site 1032480013543 putative catalytic residues [active] 1032480013544 putative Mg ion binding site [ion binding]; other site 1032480013545 putative aspartate binding site [chemical binding]; other site 1032480013546 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1032480013547 putative allosteric regulatory site; other site 1032480013548 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1032480013549 putative allosteric regulatory residue; other site 1032480013550 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1032480013551 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480013552 siderophore binding site; other site 1032480013553 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1032480013554 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480013555 siderophore binding site; other site 1032480013556 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480013557 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480013558 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480013559 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480013560 recombination protein RecR; Reviewed; Region: recR; PRK00076 1032480013561 RecR protein; Region: RecR; pfam02132 1032480013562 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1032480013563 putative active site [active] 1032480013564 putative metal-binding site [ion binding]; other site 1032480013565 tetramer interface [polypeptide binding]; other site 1032480013566 hypothetical protein; Validated; Region: PRK00153 1032480013567 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1032480013568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013569 Walker A motif; other site 1032480013570 ATP binding site [chemical binding]; other site 1032480013571 Walker B motif; other site 1032480013572 arginine finger; other site 1032480013573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480013574 putative substrate translocation pore; other site 1032480013575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480013576 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1032480013577 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1032480013578 Protein of unknown function DUF72; Region: DUF72; pfam01904 1032480013579 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1032480013580 Phosphotransferase enzyme family; Region: APH; pfam01636 1032480013581 active site 1032480013582 ATP binding site [chemical binding]; other site 1032480013583 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1032480013584 substrate binding site [chemical binding]; other site 1032480013585 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1032480013586 Protein of unknown function (DUF433); Region: DUF433; cl01030 1032480013587 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1032480013588 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1032480013589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480013590 ATP binding site [chemical binding]; other site 1032480013591 putative Mg++ binding site [ion binding]; other site 1032480013592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1032480013593 Fic/DOC family; Region: Fic; pfam02661 1032480013594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013595 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1032480013596 Walker A/P-loop; other site 1032480013597 ATP binding site [chemical binding]; other site 1032480013598 Q-loop/lid; other site 1032480013599 ABC transporter signature motif; other site 1032480013600 Walker B; other site 1032480013601 D-loop; other site 1032480013602 H-loop/switch region; other site 1032480013603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480013604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480013605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013606 Walker A/P-loop; other site 1032480013607 ATP binding site [chemical binding]; other site 1032480013608 Q-loop/lid; other site 1032480013609 ABC transporter signature motif; other site 1032480013610 Walker B; other site 1032480013611 D-loop; other site 1032480013612 H-loop/switch region; other site 1032480013613 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1032480013614 YcaO-like family; Region: YcaO; pfam02624 1032480013615 YcaO-like family; Region: YcaO; pfam02624 1032480013616 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1032480013617 YcaO-like family; Region: YcaO; pfam02624 1032480013618 TfuA-like protein; Region: TfuA; pfam07812 1032480013619 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1032480013620 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480013621 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1032480013622 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1032480013623 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1032480013624 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1032480013625 intersubunit interface [polypeptide binding]; other site 1032480013626 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1032480013627 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1032480013628 Walker A/P-loop; other site 1032480013629 ATP binding site [chemical binding]; other site 1032480013630 Q-loop/lid; other site 1032480013631 ABC transporter signature motif; other site 1032480013632 Walker B; other site 1032480013633 D-loop; other site 1032480013634 H-loop/switch region; other site 1032480013635 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1032480013636 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1032480013637 dimer interface [polypeptide binding]; other site 1032480013638 putative PBP binding regions; other site 1032480013639 ABC-ATPase subunit interface; other site 1032480013640 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1032480013641 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1032480013642 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1032480013643 putative active site [active] 1032480013644 catalytic site [active] 1032480013645 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1032480013646 putative active site [active] 1032480013647 catalytic site [active] 1032480013648 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1032480013649 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1032480013650 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480013651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480013652 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1032480013653 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1032480013654 catalytic residue [active] 1032480013655 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1032480013656 putative catalytic site [active] 1032480013657 putative metal binding site [ion binding]; other site 1032480013658 putative phosphate binding site [ion binding]; other site 1032480013659 NlpC/P60 family; Region: NLPC_P60; cl17555 1032480013660 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1032480013661 hypothetical protein; Provisional; Region: PRK06753 1032480013662 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1032480013663 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1032480013664 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1032480013665 Glutamate binding site [chemical binding]; other site 1032480013666 NAD binding site [chemical binding]; other site 1032480013667 catalytic residues [active] 1032480013668 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1032480013669 Proline dehydrogenase; Region: Pro_dh; cl03282 1032480013670 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1032480013671 Active site serine [active] 1032480013672 AAA-like domain; Region: AAA_10; pfam12846 1032480013673 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1032480013674 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1032480013675 potassium/proton antiporter; Reviewed; Region: PRK05326 1032480013676 TrkA-C domain; Region: TrkA_C; pfam02080 1032480013677 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1032480013678 nucleoside/Zn binding site; other site 1032480013679 dimer interface [polypeptide binding]; other site 1032480013680 catalytic motif [active] 1032480013681 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1032480013682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1032480013683 active site 1032480013684 Putative addiction module component; Region: Unstab_antitox; pfam09720 1032480013685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1032480013686 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1032480013687 substrate binding site [chemical binding]; other site 1032480013688 oxyanion hole (OAH) forming residues; other site 1032480013689 trimer interface [polypeptide binding]; other site 1032480013690 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1032480013691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480013692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013693 non-specific DNA binding site [nucleotide binding]; other site 1032480013694 salt bridge; other site 1032480013695 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013696 Predicted ATPase [General function prediction only]; Region: COG3903 1032480013697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480013698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1032480013699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1032480013700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1032480013701 active site 1032480013702 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1032480013703 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1032480013704 nucleotide binding site/active site [active] 1032480013705 HIT family signature motif; other site 1032480013706 catalytic residue [active] 1032480013707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1032480013708 ATP binding site [chemical binding]; other site 1032480013709 putative Mg++ binding site [ion binding]; other site 1032480013710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1032480013711 nucleotide binding region [chemical binding]; other site 1032480013712 ATP-binding site [chemical binding]; other site 1032480013713 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1032480013714 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1032480013715 classical (c) SDRs; Region: SDR_c; cd05233 1032480013716 NAD(P) binding site [chemical binding]; other site 1032480013717 active site 1032480013718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1032480013719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1032480013720 putative substrate translocation pore; other site 1032480013721 CAAX protease self-immunity; Region: Abi; pfam02517 1032480013722 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1032480013723 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1032480013724 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 1032480013725 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1032480013726 active site 1032480013727 haloalkane dehalogenase; Provisional; Region: PRK00870 1032480013728 Serine hydrolase; Region: Ser_hydrolase; cl17834 1032480013729 peptide synthase; Provisional; Region: PRK09274 1032480013730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480013731 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1032480013732 acyl-activating enzyme (AAE) consensus motif; other site 1032480013733 acyl-activating enzyme (AAE) consensus motif; other site 1032480013734 AMP binding site [chemical binding]; other site 1032480013735 active site 1032480013736 CoA binding site [chemical binding]; other site 1032480013737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1032480013738 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1032480013739 NAD(P) binding site [chemical binding]; other site 1032480013740 active site 1032480013741 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480013742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1032480013743 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1032480013744 cyclase homology domain; Region: CHD; cd07302 1032480013745 nucleotidyl binding site; other site 1032480013746 metal binding site [ion binding]; metal-binding site 1032480013747 dimer interface [polypeptide binding]; other site 1032480013748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1032480013749 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1032480013750 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1032480013751 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1032480013752 substrate binding pocket [chemical binding]; other site 1032480013753 chain length determination region; other site 1032480013754 substrate-Mg2+ binding site; other site 1032480013755 catalytic residues [active] 1032480013756 aspartate-rich region 1; other site 1032480013757 active site lid residues [active] 1032480013758 aspartate-rich region 2; other site 1032480013759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1032480013760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1032480013761 ligand binding site [chemical binding]; other site 1032480013762 flexible hinge region; other site 1032480013763 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1032480013764 non-specific DNA interactions [nucleotide binding]; other site 1032480013765 DNA binding site [nucleotide binding] 1032480013766 sequence specific DNA binding site [nucleotide binding]; other site 1032480013767 putative cAMP binding site [chemical binding]; other site 1032480013768 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1032480013769 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1032480013770 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1032480013771 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1032480013772 NAD(P) binding site [chemical binding]; other site 1032480013773 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1032480013774 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1032480013775 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1032480013776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480013777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480013778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013779 Walker A/P-loop; other site 1032480013780 ATP binding site [chemical binding]; other site 1032480013781 Q-loop/lid; other site 1032480013782 ABC transporter signature motif; other site 1032480013783 Walker B; other site 1032480013784 D-loop; other site 1032480013785 H-loop/switch region; other site 1032480013786 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1032480013787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1032480013788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1032480013789 Q-loop/lid; other site 1032480013790 ABC transporter signature motif; other site 1032480013791 Walker B; other site 1032480013792 D-loop; other site 1032480013793 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1032480013794 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 1032480013795 seryl-tRNA synthetase; Provisional; Region: PRK05431 1032480013796 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1032480013797 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1032480013798 dimer interface [polypeptide binding]; other site 1032480013799 active site 1032480013800 motif 1; other site 1032480013801 motif 2; other site 1032480013802 motif 3; other site 1032480013803 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1032480013804 active site 1032480013805 putative lipid kinase; Reviewed; Region: PRK13337 1032480013806 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1032480013807 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1032480013808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013809 dimerization interface [polypeptide binding]; other site 1032480013810 putative DNA binding site [nucleotide binding]; other site 1032480013811 putative Zn2+ binding site [ion binding]; other site 1032480013812 RES domain; Region: RES; pfam08808 1032480013813 replicative DNA helicase; Region: DnaB; TIGR00665 1032480013814 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1032480013815 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1032480013816 Walker A motif; other site 1032480013817 ATP binding site [chemical binding]; other site 1032480013818 Walker B motif; other site 1032480013819 DNA binding loops [nucleotide binding] 1032480013820 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1032480013821 putative homotetramer interface [polypeptide binding]; other site 1032480013822 putative homodimer interface [polypeptide binding]; other site 1032480013823 putative allosteric switch controlling residues; other site 1032480013824 putative metal binding site [ion binding]; other site 1032480013825 putative homodimer-homodimer interface [polypeptide binding]; other site 1032480013826 RibD C-terminal domain; Region: RibD_C; cl17279 1032480013827 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1032480013828 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1032480013829 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1032480013830 DNA binding residues [nucleotide binding] 1032480013831 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480013832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480013833 active site 1032480013834 phosphorylation site [posttranslational modification] 1032480013835 intermolecular recognition site; other site 1032480013836 dimerization interface [polypeptide binding]; other site 1032480013837 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480013838 DNA binding residues [nucleotide binding] 1032480013839 dimerization interface [polypeptide binding]; other site 1032480013840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1032480013841 Histidine kinase; Region: HisKA_3; pfam07730 1032480013842 CAAX protease self-immunity; Region: Abi; pfam02517 1032480013843 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1032480013844 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1032480013845 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1032480013846 active site 1032480013847 catalytic site [active] 1032480013848 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1032480013849 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1032480013850 active site residue [active] 1032480013851 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1032480013852 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1032480013853 putative DNA binding site [nucleotide binding]; other site 1032480013854 catalytic residue [active] 1032480013855 putative H2TH interface [polypeptide binding]; other site 1032480013856 putative catalytic residues [active] 1032480013857 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1032480013858 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1032480013859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480013860 non-specific DNA binding site [nucleotide binding]; other site 1032480013861 salt bridge; other site 1032480013862 sequence-specific DNA binding site [nucleotide binding]; other site 1032480013863 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1032480013864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1032480013865 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1032480013866 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1032480013867 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1032480013868 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1032480013869 Walker A motif; other site 1032480013870 ATP binding site [chemical binding]; other site 1032480013871 Walker B motif; other site 1032480013872 SAF domain; Region: SAF; pfam08666 1032480013873 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1032480013874 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1032480013875 EcsC protein family; Region: EcsC; pfam12787 1032480013876 Iron permease FTR1 family; Region: FTR1; pfam03239 1032480013877 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1032480013878 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1032480013879 Imelysin; Region: Peptidase_M75; pfam09375 1032480013880 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1032480013881 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1032480013882 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1032480013883 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1032480013884 active site 1032480013885 catalytic triad [active] 1032480013886 oxyanion hole [active] 1032480013887 Putative transcription activator [Transcription]; Region: TenA; COG0819 1032480013888 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1032480013889 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1032480013890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1032480013891 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1032480013892 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1032480013893 substrate-cofactor binding pocket; other site 1032480013894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480013895 catalytic residue [active] 1032480013896 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1032480013897 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1032480013898 NAD(P) binding site [chemical binding]; other site 1032480013899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1032480013900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1032480013901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1032480013902 dimerization interface [polypeptide binding]; other site 1032480013903 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1032480013904 TIR domain; Region: TIR_2; pfam13676 1032480013905 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1032480013906 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1032480013907 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1032480013908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480013909 DNA binding residues [nucleotide binding] 1032480013910 dimerization interface [polypeptide binding]; other site 1032480013911 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1032480013912 catalytic motif [active] 1032480013913 Catalytic residue [active] 1032480013914 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1032480013915 active site 1032480013916 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1032480013917 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1032480013918 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480013919 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480013920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480013921 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480013922 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1032480013923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1032480013924 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 1032480013925 Abortive infection C-terminus; Region: Abi_C; pfam14355 1032480013926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1032480013927 Transposase; Region: HTH_Tnp_1; cl17663 1032480013928 HTH-like domain; Region: HTH_21; pfam13276 1032480013929 Integrase core domain; Region: rve; pfam00665 1032480013930 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1032480013931 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1032480013932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013933 active site 1032480013934 DNA binding site [nucleotide binding] 1032480013935 Int/Topo IB signature motif; other site 1032480013936 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013937 active site 1032480013938 DNA binding site [nucleotide binding] 1032480013939 Int/Topo IB signature motif; other site 1032480013940 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1032480013941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1032480013942 active site 1032480013943 Int/Topo IB signature motif; other site 1032480013944 DNA binding site [nucleotide binding] 1032480013945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1032480013946 DNA binding site [nucleotide binding] 1032480013947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1032480013948 domain linker motif; other site 1032480013949 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1032480013950 dimerization interface [polypeptide binding]; other site 1032480013951 ligand binding site [chemical binding]; other site 1032480013952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1032480013953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1032480013954 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1032480013955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480013956 dimer interface [polypeptide binding]; other site 1032480013957 conserved gate region; other site 1032480013958 putative PBP binding loops; other site 1032480013959 ABC-ATPase subunit interface; other site 1032480013960 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1032480013961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1032480013962 dimer interface [polypeptide binding]; other site 1032480013963 conserved gate region; other site 1032480013964 ABC-ATPase subunit interface; other site 1032480013965 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1032480013966 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1032480013967 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1032480013968 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1032480013969 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1032480013970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1032480013971 Walker A motif; other site 1032480013972 ATP binding site [chemical binding]; other site 1032480013973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1032480013974 Integrase core domain; Region: rve; pfam00665 1032480013975 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1032480013976 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1032480013977 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1032480013978 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1032480013979 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1032480013980 active site 1032480013981 citrylCoA binding site [chemical binding]; other site 1032480013982 oxalacetate binding site [chemical binding]; other site 1032480013983 coenzyme A binding site [chemical binding]; other site 1032480013984 catalytic triad [active] 1032480013985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480013986 TAP-like protein; Region: Abhydrolase_4; pfam08386 1032480013987 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1032480013988 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1032480013989 putative NAD(P) binding site [chemical binding]; other site 1032480013990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1032480013991 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1032480013992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1032480013993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1032480013994 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1032480013995 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1032480013996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480013997 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1032480013998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480013999 dimerization interface [polypeptide binding]; other site 1032480014000 putative DNA binding site [nucleotide binding]; other site 1032480014001 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480014002 putative Zn2+ binding site [ion binding]; other site 1032480014003 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1032480014004 ResB-like family; Region: ResB; pfam05140 1032480014005 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1032480014006 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1032480014007 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1032480014008 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1032480014009 putative active site [active] 1032480014010 catalytic triad [active] 1032480014011 putative dimer interface [polypeptide binding]; other site 1032480014012 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1032480014013 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1032480014014 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1032480014015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1032480014016 catalytic residues [active] 1032480014017 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1032480014018 putative active site [active] 1032480014019 redox center [active] 1032480014020 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1032480014021 Thioredoxin; Region: Thioredoxin_4; cl17273 1032480014022 Thioredoxin; Region: Thioredoxin_4; cl17273 1032480014023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480014024 dimerization interface [polypeptide binding]; other site 1032480014025 putative DNA binding site [nucleotide binding]; other site 1032480014026 putative Zn2+ binding site [ion binding]; other site 1032480014027 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1032480014028 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1032480014029 nitrous-oxide reductase; Validated; Region: PRK02888 1032480014030 CAAX protease self-immunity; Region: Abi; pfam02517 1032480014031 CopC domain; Region: CopC; pfam04234 1032480014032 Copper resistance protein D; Region: CopD; pfam05425 1032480014033 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1032480014034 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1032480014035 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1032480014036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480014037 putative DNA binding site [nucleotide binding]; other site 1032480014038 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1032480014039 putative Zn2+ binding site [ion binding]; other site 1032480014040 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1032480014041 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1032480014042 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1032480014043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1032480014044 dimerization interface [polypeptide binding]; other site 1032480014045 putative DNA binding site [nucleotide binding]; other site 1032480014046 putative Zn2+ binding site [ion binding]; other site 1032480014047 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1032480014048 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1032480014049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480014050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480014051 sequence-specific DNA binding site [nucleotide binding]; other site 1032480014052 salt bridge; other site 1032480014053 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1032480014054 helix-hairpin-helix signature motif; other site 1032480014055 active site 1032480014056 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1032480014057 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1032480014058 ATP binding site [chemical binding]; other site 1032480014059 substrate binding site [chemical binding]; other site 1032480014060 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1032480014061 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1032480014062 Ligand Binding Site [chemical binding]; other site 1032480014063 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1032480014064 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1032480014065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480014066 Zn2+ binding site [ion binding]; other site 1032480014067 Mg2+ binding site [ion binding]; other site 1032480014068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480014069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480014070 sequence-specific DNA binding site [nucleotide binding]; other site 1032480014071 salt bridge; other site 1032480014072 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480014073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480014074 non-specific DNA binding site [nucleotide binding]; other site 1032480014075 salt bridge; other site 1032480014076 sequence-specific DNA binding site [nucleotide binding]; other site 1032480014077 Domain of unknown function (DUF955); Region: DUF955; cl01076 1032480014078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480014079 non-specific DNA binding site [nucleotide binding]; other site 1032480014080 salt bridge; other site 1032480014081 sequence-specific DNA binding site [nucleotide binding]; other site 1032480014082 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1032480014083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480014084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480014085 phosphopeptide binding site; other site 1032480014086 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1032480014087 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1032480014088 phosphopeptide binding site; other site 1032480014089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1032480014090 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1032480014091 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1032480014092 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1032480014093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1032480014094 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1032480014095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480014096 active site 1032480014097 ATP binding site [chemical binding]; other site 1032480014098 substrate binding site [chemical binding]; other site 1032480014099 activation loop (A-loop); other site 1032480014100 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480014101 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480014102 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1032480014103 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1032480014104 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1032480014105 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1032480014106 ligand binding site [chemical binding]; other site 1032480014107 NAD binding site [chemical binding]; other site 1032480014108 catalytic site [active] 1032480014109 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1032480014110 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480014111 PYR/PP interface [polypeptide binding]; other site 1032480014112 dimer interface [polypeptide binding]; other site 1032480014113 TPP binding site [chemical binding]; other site 1032480014114 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480014115 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480014116 TPP-binding site [chemical binding]; other site 1032480014117 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1032480014118 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1032480014119 active site 1032480014120 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480014121 AsnC family; Region: AsnC_trans_reg; pfam01037 1032480014122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1032480014123 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1032480014124 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1032480014125 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1032480014126 glutamine binding [chemical binding]; other site 1032480014127 catalytic triad [active] 1032480014128 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1032480014129 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1032480014130 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1032480014131 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1032480014132 Ion channel; Region: Ion_trans_2; pfam07885 1032480014133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1032480014134 active site 1032480014135 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1032480014136 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1032480014137 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1032480014138 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1032480014139 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1032480014140 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1032480014141 dimer interface [polypeptide binding]; other site 1032480014142 ssDNA binding site [nucleotide binding]; other site 1032480014143 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1032480014144 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1032480014145 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1032480014146 Putative esterase; Region: Esterase; pfam00756 1032480014147 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1032480014148 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1032480014149 Peptidase family M48; Region: Peptidase_M48; cl12018 1032480014150 endonuclease IV; Provisional; Region: PRK01060 1032480014151 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1032480014152 AP (apurinic/apyrimidinic) site pocket; other site 1032480014153 DNA interaction; other site 1032480014154 Metal-binding active site; metal-binding site 1032480014155 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1032480014156 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1032480014157 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1032480014158 Walker A/P-loop; other site 1032480014159 ATP binding site [chemical binding]; other site 1032480014160 Q-loop/lid; other site 1032480014161 ABC transporter signature motif; other site 1032480014162 Walker B; other site 1032480014163 D-loop; other site 1032480014164 H-loop/switch region; other site 1032480014165 Protein of unknown function (DUF419); Region: DUF419; cl15265 1032480014166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1032480014167 H+ Antiporter protein; Region: 2A0121; TIGR00900 1032480014168 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1032480014169 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1032480014170 active site 1032480014171 NTP binding site [chemical binding]; other site 1032480014172 metal binding triad [ion binding]; metal-binding site 1032480014173 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1032480014174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1032480014175 Zn2+ binding site [ion binding]; other site 1032480014176 Mg2+ binding site [ion binding]; other site 1032480014177 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1032480014178 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1032480014179 ATP binding site [chemical binding]; other site 1032480014180 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1032480014181 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 1032480014182 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1032480014183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1032480014184 DNA binding residues [nucleotide binding] 1032480014185 AAA domain; Region: AAA_14; pfam13173 1032480014186 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1032480014187 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1032480014188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1032480014189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1032480014190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1032480014191 catalytic residues [active] 1032480014192 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1032480014193 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1032480014194 TIGR04255 family protein; Region: sporadTIGR04255 1032480014195 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1032480014196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1032480014197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1032480014198 non-specific DNA binding site [nucleotide binding]; other site 1032480014199 salt bridge; other site 1032480014200 sequence-specific DNA binding site [nucleotide binding]; other site 1032480014201 hypothetical protein; Provisional; Region: PRK01346 1032480014202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480014203 Coenzyme A binding pocket [chemical binding]; other site 1032480014204 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1032480014205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1032480014206 Coenzyme A binding pocket [chemical binding]; other site 1032480014207 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1032480014208 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1032480014209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1032480014210 homodimer interface [polypeptide binding]; other site 1032480014211 catalytic residue [active] 1032480014212 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1032480014213 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1032480014214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1032480014215 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1032480014216 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480014217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1032480014218 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1032480014219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1032480014220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1032480014221 active site 1032480014222 phosphorylation site [posttranslational modification] 1032480014223 intermolecular recognition site; other site 1032480014224 dimerization interface [polypeptide binding]; other site 1032480014225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1032480014226 DNA binding residues [nucleotide binding] 1032480014227 dimerization interface [polypeptide binding]; other site 1032480014228 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1032480014229 ATP binding site [chemical binding]; other site 1032480014230 Mg2+ binding site [ion binding]; other site 1032480014231 G-X-G motif; other site 1032480014232 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1032480014233 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1032480014234 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1032480014235 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1032480014236 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1032480014237 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1032480014238 FAD binding pocket [chemical binding]; other site 1032480014239 FAD binding motif [chemical binding]; other site 1032480014240 phosphate binding motif [ion binding]; other site 1032480014241 NAD binding pocket [chemical binding]; other site 1032480014242 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1032480014243 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1032480014244 PYR/PP interface [polypeptide binding]; other site 1032480014245 dimer interface [polypeptide binding]; other site 1032480014246 TPP binding site [chemical binding]; other site 1032480014247 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1032480014248 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1032480014249 TPP-binding site [chemical binding]; other site 1032480014250 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1032480014251 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1032480014252 ParB-like nuclease domain; Region: ParBc; pfam02195 1032480014253 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1032480014254 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480014255 P-loop; other site 1032480014256 Magnesium ion binding site [ion binding]; other site 1032480014257 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1032480014258 Magnesium ion binding site [ion binding]; other site 1032480014259 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1032480014260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1032480014261 S-adenosylmethionine binding site [chemical binding]; other site 1032480014262 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1032480014263 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1032480014264 G-X-X-G motif; other site 1032480014265 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1032480014266 RxxxH motif; other site 1032480014267 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1032480014268 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1032480014269 Haemolytic domain; Region: Haemolytic; pfam01809 1032480014270 Ribonuclease P; Region: Ribonuclease_P; cl00457